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Journal articles on the topic '340.134 (477)(043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Holt, Thomas C., Brian K. Maynard, and William A. Johnson. "447 Nutrient Removal by Five Ornamental Wetland Plant Species Grown in Treatment-production Wetland Biofilters." HortScience 34, no. 3 (1999): 521D—521. http://dx.doi.org/10.21273/hortsci.34.3.521d.

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We assessed the capacity for nutrient removal of ornamental water garden plants being grown in treatment-production wetland biofilters. Plant biomass, nutrient uptake, tissue nutrient content, and production potential were compared for five popular ornamental water garden plant species: Typha latifolia L., Iris pseudacorus L., Phalaris arundinacea L. `Picta', Canna glauca L., and Colocasia esculenta (L.) Schott. Plants were grown in triplicate 0.3 m2 × 0.3 m, deep gravelbed mesocosms fed with 20N-20P-20K Peter's fertilizer (Scotts-Sierra Horticultural Products Co., Marysville, Ohio) reconstitu

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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico

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Arshad, S., I. Hussain, M. Ibrahim, et al. "Biochemical studies on protein, phenolic contents and antioxidant activities of Sida cordifolia extracts." Bulletin of the Chemical Society of Ethiopia 34, no. 2 (2020): 427–34. http://dx.doi.org/10.4314/bcse.v34i2.18.

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The study aimed to characterize the antioxidant properties regarding the Sida cordifolia with special reference to its detailed biochemical analysis. The study revealed that chlorophyll A (0.9 ± 0.3 mg/g), total chlorophyll content (3.0 ± 0.7 mg/g), total carotenoid content (0.3 ± 0.1 mg/g), total soluble proteins (7.5 ± 0.1 mg/g), and total phenolic contents (5.6 ± 1.3 mg/g) were found highest in flower tissue of S. cordifolia. However, peroxidase (POD) contents (118 ± 31 units/g), superoxide dismutase (SOD) activity (64 ± 1.5 units/g) were maximum in the leaf tissues, while catalase (CAT) co

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Nakayama, Y., R. Nakashima, T. Handa, et al. "POS1051 LUNG CLUSTERING ANALYSIS-BASED PHENOTYPES OF RHEUMATOID ARTHRITIS USING ARTIFICIAL INTELLIGENCE-BASED TECHNOLOGY FOR CHEST COMPUTED TOMOGRAPHY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 843.1–844. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2178.

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BackgroundLung involvement is a prevalent extraarticular manifestation of rheumatoid arthritis (RA) that remains a significant clinical challenge. Few studies have comprehensively quantified lung abnormalities of RA patients using artificial intelligence-based (AI) technology.ObjectivesThe aim of this study was to quantify lung lesions in RA patients and classify them based on their lung parameters.MethodsAn AI-based quantitative computed tomography (CT) image analysis software (AIQCT) was applied to high-resolution CT scans of RA patients in a cross-sectional manner. AIQCT automatically class

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Yusuf, Bustanil, Kabul Budiman, and Nursalam Nursalam. "ANALYSIS OF FARMING NILAM (POGOSTEMON CABLIN BENTH) AT TOARI DISTRICT OF KOLAKA." Agribusiness Journal 1, no. 2 (2016): 33–41. http://dx.doi.org/10.31327/aj.v1i2.155.

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This research aims to; 1) determine the factors that affect the production of patchouli production, 2) determine the allocative efficiency of production factors patchouli farming, 3) determine the scale of business, 4) To determine the financial feasibility of farming patchouli. The sample in this study is a research location patchouli farmers totaling 50 respondents. Data were analyzed using Cobb-Douglass, Statistics Test Analysis, analysis of allocative efficiency, scale of operations and financial feasibility. This study shows that: 1) The results of the analysis test F known that simultane

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Peterson, B. T., J. A. Brooks, and R. W. Hyde. "Lung fluid balance during acute renal failure in sheep." Journal of Applied Physiology 60, no. 4 (1986): 1333–40. http://dx.doi.org/10.1152/jappl.1986.60.4.1333.

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To determine whether uremia changes lung vascular permeability, we measured the flow of lymph and proteins from the lungs of acutely uremic sheep. Acute renal failure was induced by either bilateral nephrectomy or by reinfusing urine. Both models of renal failure increased the plasma creatinine from 0.8 +/- 0.3 to 11 +/- 1 mg/dl in 3 days but caused no significant change in the flow of lymph from the lungs. To determine whether uremia increased the protein clearance response to elevated pulmonary microvascular pressures, we inflated a balloon in the left atrium for 2 h before and 3 days after

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Alpizar-Rodriguez, D., F. Irazoque-Palazuelos, T. S. Rodriguez-Reyne, et al. "POS1242 FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS WITH RHEUMATIC DISEASES AND COVID-19 IN MEXICO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 904.1–904. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3342.

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Background:As of the 25th of January 2021, more than 150 thousand deaths as consequence of COVID-19 have been reported in Mexico [1]. Advanced age, male gender and comorbidities have been described as risk factors for severe disease and mortality in general population [2]. COVID-19 mortality in Mexican patients with rheumatic and musculoskeletal diseases (RMDs) is unknown.Objectives:To describe characteristics of Mexican patients with RMDs and COVID-19, and to analyse factors associated with mortality.Methods:The Global Rheumatology Alliance COVID-19 (GRA) physician reported registry, is an in

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Zhigareva, A. V., A. S. Ametov, H. H. Sharafetdinov, and E. Yu Pashkova. "Correction of Metabolic Disorders in Patients with Type 2 Diabetes Mellitus Using a Type 2 Sodium-Glucose Cotransporter Inhibitor." Doctor.Ru 22, no. 4 (2023): 53–58. http://dx.doi.org/10.31550/1727-2378-2023-22-4-53-58.

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Aim: Comprehensive (clinical, laboratory, instrumental) assessment of the clinical efficacy of metabolic disorders correction in patients with type 2 diabetes mellitus using a type 2 sodium-glucose cotransporter inhibitor. Design: Randomized comparative study. Materials and methods. A 26-week study included 130 patients with the presence of visceral obesity (56.3 ± 2.1 years) who did not reach the target parameters of glycated hemoglobin (HbA1c) on metformin monotherapy 2 g/day. The main group (68 people) received canagliflozin 300 mg/day, in combination with metformin 2 g/day; the control gro

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Jannasch, R. W., E. Charmley, and A. V. Rodd. "The effect of spring turnout date on weight gain by cattle on native pasture." Canadian Journal of Animal Science 82, no. 4 (2002): 575–85. http://dx.doi.org/10.4141/a01-069.

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The effect of early turnout on pasture quality and weight gain by beef cattle was assessed with 32 Hereford feeder cattle which were turned out on pasture on four separate dates in each of 2 yr in a randomized complete block design with two replications. In 1998, steers were allocated to four treatments numbered consecutively T1 to T4 according to turnout date: 6 May [110 growing degree days above 5°C (GDD)], 13 May (152 GDD), 20 May (195 GDD) and 27 May (255 GDD). Steers grazed separate 0.4-ha paddocks continuously for 28 d. In 1999, turnout dates were 11 May (124 GDD), 18 May (156 GDD), 26 M

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Feldman, Darren R., Patrick Gagnon-Sanschagrin, Jessica Maitland, et al. "Time to real-world progression (TTrwP) among patients (pts) with relapsed/refractory (R/R) testicular germ cell tumors (GCT) undergoing palliative chemotherapy (CT) in the United States (US)." Journal of Clinical Oncology 43, no. 5_suppl (2025): 628. https://doi.org/10.1200/jco.2025.43.5_suppl.628.

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628 Background: Pts with R/R testicular GCT are considered to be incurable, having experienced progressive disease (PD) after salvage conventional-dose CT (CDCT) and/or high-dose CT (HDCT). Therapeutic options are limited to palliative CT, with an estimated real-world (rw) overall survival of 8 months from initiation of their first palliative CT regimen. Understanding TTrwP may help further inform clinical care. Methods: The Komodo Research Database (KRD; 01/2016-03/2023) was used to identify adult males in the US with testicular GCT who received palliative CT after salvage CT. TTrwP was estim

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Hays, Michael D., David K. Ryan, and Stephen Pennell. "Multi-Wavelength Fluorescence-Quenching Model for Determination of Cu2+ Conditional Stability Constants and Ligand Concentrations of Fulvic Acid." Applied Spectroscopy 57, no. 4 (2003): 454–60. http://dx.doi.org/10.1366/00037020360626005.

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In this work, a multi-wavelength model (MWM) is developed. It uses fluorescence bands in the fulvic acid (FA) spectrum that quench upon binding of inorganic Cu2+ to FA. Quenching data at pH values of 5, 6, and 7 are placed in sets, containing fluorescence measures at select wavelengths versus added copper ( CM). Intensity data of wavelength set 1 are obtained from 25 nm constant offset synchronous fluorescence spectra (SyF), in which are observed distinct peaks (λex = 415 nm, λem = 440 nm; and λex = 471 nm, λem = 496 nm). Wavelength set 2 intensity data are obtained from the FA fluorescence ex

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Gossai, Nathan, Stuart S. Winter, Meenakshi Devidas, et al. "Prognostic Impact of CNS-2 status in T-ALL: A report from the Children’s Oncology Group." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10003. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10003.

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10003 Background: In B-acute lymphoblastic leukemia (B-ALL), CNS2 was associated with inferior 5-year (yr) event-free and overall survival (EFS/OS) in recent trials. Here, we report the impact of CNS2 in T-ALL on AALL0434 and AALL1231, recently completed consecutive randomized phase 3 trials for children and young adults with T-ALL and T Lymphoblastic Lymphoma. This report is limited to T-ALL. Both trials used augmented Berlin Frankfurt Münster regimens. AALL0434 compared Capizzi escalating methotrexate+pegaspargase (C-MTX) vs High Dose MTX (HDMTX) +/- six nelarabine (Nel) courses; outcomes im

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Kepert, Cameron J., Lioubov I. Semenova, Lu Wei-Min, Brian W. Skelton, and Allan H. White. "Structural Systematics of Rare Earth Complexes. XII Solvated 1 : 1 Adducts of Some Lanthanoid(III) Carboxylates with 1,10-Phenanthroline and 2,2′:6′,2″-Terpyridine." Australian Journal of Chemistry 52, no. 6 (1999): 481. http://dx.doi.org/10.1071/ch98043.

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A room-temperature single-crystal X-ray structure determination of the 1 : 1 adduct of 1,10-phenanthroline (`phen") with lutetium(III) acetate (as its dihydrate) is recorded. Crystals are triclinic, P 1, a 12·430(8), b 10·681(4), c 8·134(8) Å, α 74·76(6), β 84·81(7), γ 74·29(4)°, Z = 2 f.u.; conventional R on |F| was 0·031 for No 3939 independent ‘observed’ (I > 3σ(I)) diffractometer reflections. The complex [(N,N′-phen)(O,O′-ac)Lu(O-ac-O′)4Lu(O,O′-ac)(N,N′-phen)].2H2O is binuclear, the lutetium being eight-coordinated by bidentate phen and ac (acetate) ligands and four oxygen atoms from th

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Walz, Lars, Gian M. Salzmann, Thomas Fabbro, Stefan Eichhorn, and Andreas B. Imhoff. "The Anatomic Reconstruction of Acromioclavicular Joint Dislocations Using 2 TightRope Devices." American Journal of Sports Medicine 36, no. 12 (2008): 2398–406. http://dx.doi.org/10.1177/0363546508322524.

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Background For the reconstruction of acromioclavicular (AC) joint separation, several operative procedures have been described; however, the anatomic reconstruction of both coracoclavicular ligaments has rarely been reported. Purpose The aim of this biomechanical study is to describe a new procedure for anatomic reconstruction of the AC joint. Study Design Controlled laboratory study. Materials and Methods Forty fresh-frozen cadaveric shoulders were tested. Cyclic loading and a load-to-failure protocol was performed in vertical (native, n = 10; reconstructed, n = 10) and anterior directions (n

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Radchenko, Elena V., Olga A. Sykhovskaya, Timofey L. Galankin, Aleksei S. Kolbin, and Maria A. Smirnova. "Network meta-analysis: a comparison of effectiveness and safety of partial agonists of nicotinic acetylcholine receptors varenicline and cytisine for smoking cessation." Reviews on Clinical Pharmacology and Drug Therapy 16, no. 4 (2018): 19–32. http://dx.doi.org/10.17816/rcf16419-32.

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Background. Partial agonists of α4b2 nicotinic acetylcholine receptors are the most effective treatment strategy for tobacco smoking cessation. They are able to alleviate withdrawal symptoms and to reduce smoking satisfaction. The aim of this study was to review the efficacy and safety of nicotinic receptor partial agonists varenicline and cytisine, for smoking cessation. Methods. A search for randomized controlled trials was done using the terms (“cytisine”, “tabex”, “varenicline” or 'partial agonists of nicotinic receptors’) in MEDLINE, EMBASE, eLibrary in May 2018. Types of part

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Kenet, Gili, Fenella Kirkham, Christoph Bidligmaier, and Ulrike Nowak-Gottl. "European Collaborative Paediatric Database on Cerebral Sinus Venous Thrombosis (CVT): Risk of Recurrent Venous Thrombosis (Update 2005)." Blood 106, no. 11 (2005): 1629. http://dx.doi.org/10.1182/blood.v106.11.1629.1629.

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Abstract The present European database study was designed to evaluate the risk of recurrent venous thrombosis (rVT) in 407 consecutively recruited CVT children from the Israel, United Kingdom, and Germany. Children were recruited between January 1996 and January 2003. 330 of them were prospectively followed at least 12 months. Median(range) age at first thrombosis onset was 5.3 years (newborn to &lt; 18; male: 55%). The median(range) follow-up time was 33months (12–216). Acute antithrombotic treatment (AT) with UFH or LMWH was applied in 252 of 330 patients (76.4%), followed by secondary A

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Bottinor, Wendy, Haoxue Xiang, Yan Chen, et al. "Cardiovascular risk factor severity and adverse cardiovascular events: A report from the Childhood Cancer Survivor Study (CCSS)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 12055. https://doi.org/10.1200/jco.2025.43.16_suppl.12055.

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12055 Background: Among survivors of childhood cancer, more severe grades of CVRFs are associated with increased risk for adverse cardiovascular events (ACE). The impact of low severity CVRFs has not been defined. Methods: Among 25,723 long-term survivors of childhood cancer, CVRF severity was graded using longitudinal self-report: Grade 1 conditions are reported but not on medications; Grade 2 are prescribed medications. Cumulative incidence of CVRFs were estimated into the 6 th decade of life with death and Grade 2 CVRFs a competing risk event for Grade 1 CVRFs. Starting at 1st report of a C

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Miyamoto, Gisela Cristiane, Katherinne Ferro Moura Franco, Johanna M. van Dongen, et al. "Different doses of Pilates-based exercise therapy for chronic low back pain: a randomised controlled trial with economic evaluation." British Journal of Sports Medicine 52, no. 13 (2018): 859–68. http://dx.doi.org/10.1136/bjsports-2017-098825.

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ObjectivesTo evaluate the effectiveness and cost-utility of the addition of different doses of Pilates to an advice for non-specific chronic low back pain (NSCLBP) from a societal perspective.DesignRandomised controlled trial with economic evaluation.SettingPhysiotherapy clinic in São Paulo, Brazil.Participants296 patients with NSCLBP.InterventionsAll patients received advice and were randomly allocated to four groups (n=74 per group): booklet group (BG), Pilates once a week (Pilates group 1, PG1), Pilates twice a week (Pilates group 2, PG2) and Pilates three times a week (Pilates group 3, PG3

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Jacobsen, S., O. Johansen, and L. Garby. "A 24-m3 direct heat-sink calorimeter with on-line data acquisition, processing, and control." American Journal of Physiology-Endocrinology and Metabolism 249, no. 4 (1985): E416—E432. http://dx.doi.org/10.1152/ajpendo.1985.249.4.e416.

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The construction and performance of a 24-m3 direct heat-sink calorimeter for continuous measurement of evaporative and sensible heat loss in human subjects are described. Extensive use of real-time processing for compensation of physical time constants and delays made it possible to solve response-time and stability problems associated with the large volume. The performance characteristics of the calorimeter are 1) a linear response between 0 and 320 W (471 g . h-1) for evaporative heat with a precision of 4.0-0.6% in the range 25-100 W, 2) a linear response between 0 and 280 W for sensible he

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Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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Arter, Zhaohui Liao, Robert Hsu, and David Benjamin. "Abstract 1288: Evaluating gender and country of origin diversity on editorial boards in thoracic, gastrointestinal, and breast oncology journals." Cancer Research 84, no. 6_Supplement (2024): 1288. http://dx.doi.org/10.1158/1538-7445.am2024-1288.

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Abstract Background: The composition and diversity of editorial board members in oncology journals are critical indicators of the field's inclusivity and global perspective. Despite a historical trend of female underrepresentation on editorial boards of peer-reviewed medical journals, the extent of diversity within oncology's various subspecialties remains less understood. This study aims to elucidate the landscape of gender and economic diversity among editorial boards in three major oncology subspecialties: thoracic, gastrointestinal (GI), and breast oncology. Methods: 5 top oncology journal

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Teshima, Takanori, K. Matsuo, K. Matsue, et al. "Impact of HLA Mismatch on the Incidence of Acute GVHD and Rejection after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation (RICT)." Blood 104, no. 11 (2004): 2758. http://dx.doi.org/10.1182/blood.v104.11.2758.2758.

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Abstract HLA incompatibility between the donor and recipient is the most critical factor governing the incidence of rejection and GVHD after conventional allogeneic stem cell transplantation. But the impact of HLA disparity on GVHD and graft rejection after RICT remains to be elucidated. We retrospectively analyzed the outcomes of 437 patients who underwent bone marrow (n=95) or peripheral blood stem cell RICT (n=342). The numbers of patients who received a graft from a HLA-matched (275 from siblings, 11 from family members, and 54 from unrelated donors), one-locus-mismatched, 2- or 3-loci-mis

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Chadha, Raminder, Ruchika Goel, and Clifford M. Takemoto. "Mortality Associated with Venous Thromboembolism in Hospitalized Pediatric Patients: A Single Tertiary Care Institute Experience." Blood 126, no. 23 (2015): 629. http://dx.doi.org/10.1182/blood.v126.23.629.629.

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Abstract Background: Hospital-associated venous thromboembolism (HA-VTE) is a major cause of morbidity and mortality in adults; there is a paucity of data about mortality risk in children. Objective: To determine clinical factors associated with mortality in children with HA-VTE. Methods: We conducted retrospective chart review of patients <=21 years with HA-VTE admitted to the Johns Hopkins Hospital from 1992-2013. ICD-9 codes were used to identify cases with deep venous thrombosis and pulmonary embolism; diagnosis was verified by reviewing hospital records and radiologic imaging. HA-VTE w

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Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Chaverri, Carlos, and José F. Cicció. "Essential oils of Baccharis trinervis (Asteraceae) from Costa Rica." Revista de Biología Tropical 65, no. 4 (2017): 1307. http://dx.doi.org/10.15517/rbt.v65i4.27845.

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Baccharis is an Asteraceae genus of flowering plants, which has about 340 to 400 species, ranging from the Southern United States to the Southern extreme of Argentina and Chile through Central America and the Caribbean regions. The species Baccharis trinervis is a native shrub from Mexico, Central America and throughout South America. In Costa Rica, this species is commonly known as alcotán and the fresh leaves are used as a poultice on wounds and ulcers. The objective of the present research was to characterize the chemical composition of seven hydrodistilled essential oils of diverse morphol

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Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Morlà, R., T. LI, G. Luta, and T. Pincus. "AB0786 Self-reported disease burden is greater in spondyloarthritis than in rheumatoid arthritis patients according to multidimensional questionnaire (MDHAQ / RAPID3) scores, despite fewer females, who generally have higher scores on patient questionnaires." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1520.1–1520. http://dx.doi.org/10.1136/annrheumdis-2022-eular.852.

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BackgroundFemale patients generally have higher scores than males on most items on self-report questionnaires, including MDHAQ/RAPID3 (multi-dimensional health assessment questionnaire/routine assessment of patient index data)1. MDHAQ/RAPID3 was validated in patients with rheumatoid arthritis (RA), but is informative in all diseases studied, including spondyloarthritis (SpA)2. More SpA patients are men than RA patients, suggesting lower scores, but MDHAQ scores are higher in SpA than RA.ObjectivesWe compared self-report MDHAQ/RAPID3 scores in RA vs SpA patients according to gender.MethodsPatie

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Magrey, M., M. G. H. Van de Sande, M. Breban, et al. "POS1107 BIMEKIZUMAB ACHIEVED SUSTAINED IMPROVEMENTS IN EFFICACY OUTCOMES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS, REGARDLESS OF PRIOR TNF INHIBITOR TREATMENT: WEEK 52 POOLED RESULTS FROM TWO PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 876–77. http://dx.doi.org/10.1136/annrheumdis-2023-eular.836.

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BackgroundIn patients (pts) with axial spondyloarthritis (axSpA), tumour necrosis factor inhibitors (TNFi) are the usual first line biologic treatment, yet many pts may experience loss of response over time, and some are intolerant to TNFis.[1]Typically, response to second line biologics is limited in TNFi-inadequate responders (IR).Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In the phase 3 BE MOBILE 1 and 2 studies, BKZ treatment resulted in rapid and sustained improvements in efficacy outcomes through 52 weeks (wks) in pts with acti

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Meza, Nicolás, J. L. Prieto, A. Clocchiatti, et al. "The extraplanar type II supernova ASASSN-14jb in the nearby edge-on galaxy ESO 467-G051." Astronomy & Astrophysics 629 (September 2019): A57. http://dx.doi.org/10.1051/0004-6361/201834972.

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We present optical photometry and spectroscopy of the Type II supernova ASASSN-14jb, together with Very Large Telescope (VLT) Multi Unit Spectroscopic Explorer (MUSE) integral field observations of its host galaxy and a nebular-phase spectrum. This supernova, in the nearby galaxy ESO 467-G051 (z = 0.006), was discovered and followed-up by the all-sky automated survey for supernovae (ASAS-SN). We obtained well-sampled las cumbres network (LCOGTN) BVgri and Swift w2m1w1ubv optical, near-UV/optical light curves, and several optical spectra in the early photospheric phases. The transient ASASSN-14

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Garbin, Marta, Hélène LM Ruel, Ryota Watanabe, Annie Malo, Beatriz P. Monteiro, and Paulo V. Steagall. "Analgesic efficacy of an ultrasound-guided transversus abdominis plane block with bupivacaine in cats: a randomised, prospective, masked, placebo-controlled clinical trial." Journal of Feline Medicine and Surgery 25, no. 2 (2023): 1098612X2311544. http://dx.doi.org/10.1177/1098612x231154463.

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Objectives This randomised, prospective, masked clinical trial evaluated the postoperative analgesic efficacy of an ultrasound-guided transversus abdominis plane block (TAPB) with bupivacaine in cats undergoing ovariohysterectomy. Methods Thirty-two healthy adult female cats undergoing elective ovariohysterectomy were randomised to undergo TAPB with bupivacaine (treatment group [TG], n = 16) vs placebo (control group [CG], n = 16) in addition to preoperative analgesia with buprenorphine (0.02 mg/kg IM). All patients received a general anaesthetic and, before surgical incision, a bilateral two-

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Orbai, A. M., L. C. Coates, A. Deodhar, et al. "POS1029 GUSELKUMAB-TREATED PATIENTS WITH PSORIATIC ARTHRITIS ACHIEVED CLINICALLY MEANINGFUL IMPROVEMENTS IN GENERAL HEALTH OUTCOMES MEASURED WITH PROMIS-29 THROUGH 52 WEEKS: RESULTS FROM THE PHASE 3 DISCOVER-1 TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 785–86. http://dx.doi.org/10.1136/annrheumdis-2021-eular.471.

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Background:In the DISCOVER-1 study, the interleukin-23 p19 subunit inhibitor guselkumab (GUS) demonstrated robust efficacy across joint and skin clinical manifestations of psoriatic arthritis (PsA).1 Patients (pts) with PsA also experience a broad range of symptoms that negatively impact health-related quality of life (eg, pain, fatigue, anxiety, depression, sleep disturbance, poor physical function).2Objectives:Assess the treatment effect of GUS on general health outcomes in pts with PsA in the DISCOVER-1 trial through Week (W) 52 using the Patient-Reported Outcomes Measurement Information Sy

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Hammer, H. B., B. Michelsen, J. Sexton, T. Uhlig, and S. Aarrestad Provan. "THU0129 SLEEP DISTURBANCE AND LOW INFLAMMATION PREDICT A PATTERN OF CHRONIC FATIGUE IN ACTIVELY TREATED PATIENTS WITH ESTABLISHED RA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 279.2–280. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3532.

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Background:Fatigue is common among patients with rheumatoid arthritis (RA) and has major impact on the burden of disease. There is little knowledge regarding the factors predicting the longitudinal development of chronic fatigue.Objectives:To identify baseline predictors for the development of chronic fatigue in patients with RA who initiate biological DMARD (bDMARD) treatment, and to compare disease courses across categories of fatigue for 12 months follow-up.Methods:Different trajectories of fatigue were calculated from a cohort of 209 established RA patients initiating bDMARDs. Fatigue was

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Holanda, Bruna A., Mira L. Pöhlker, David Walter, et al. "Influx of African biomass burning aerosol during the Amazonian dry season through layered transatlantic transport of black carbon-rich smoke." Atmospheric Chemistry and Physics 20, no. 8 (2020): 4757–85. http://dx.doi.org/10.5194/acp-20-4757-2020.

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Abstract. Black carbon (BC) aerosols influence the Earth's atmosphere and climate, but their microphysical properties, spatiotemporal distribution, and long-range transport are not well constrained. This study presents airborne observations of the transatlantic transport of BC-rich African biomass burning (BB) smoke into the Amazon Basin using a Single Particle Soot Photometer (SP2) as well as several complementary techniques. We base our results on observations of aerosols and trace gases off the Brazilian coast onboard the HALO (High Altitude and LOng range) research aircraft during the ACRI

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Schifman, Ron B., Michael Talbert, and Rhona J. Souers. "Delta Check Practices and Outcomes: A Q-Probes Study Involving 49 Health Care Facilities and 6541 Delta Check Alerts." Archives of Pathology & Laboratory Medicine 141, no. 6 (2017): 813–23. http://dx.doi.org/10.5858/arpa.2016-0161-cp.

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Context.— Delta checks serve as a patient-based quality control tool to detect testing problems. Objective.— To evaluate delta check practices and outcomes. Design.— Q-Probes participants provided information about delta check policies and procedures. Information about investigations, problems, and corrective actions was prospectively collected for up to 100 testing episodes involving delta check alerts. Results.— Among 4505 testing episodes involving 6541 delta check alerts, the median frequencies of actions taken among 49 laboratories were clinical review, 38.0%; retest, 25.0%, or recheck, 2

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Coates, L. C., R. B. Warren, C. T. Ritchlin, et al. "POS1022 BIMEKIZUMAB SAFETY AND EFFICACY IN PATIENTS WITH PSORIATIC ARTHRITIS: 3-YEAR RESULTS FROM A PHASE 2b OPEN-LABEL EXTENSION STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 779–80. http://dx.doi.org/10.1136/annrheumdis-2021-eular.124.

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Background:Bimekizumab (BKZ), a monoclonal antibody inhibitor of interleukin (IL)-17A and IL-17F, demonstrated clinical improvements in joint and skin outcomes up to 108 weeks (wks) in patients (pts) with active psoriatic arthritis (PsA).1,2Objectives:To report up to 3-year safety and efficacy of BKZ in pts with active PsA from a 48-week phase 2b dose-ranging study (BE ACTIVE; NCT02969525) and its open-label extension (OLE; NCT03347110).Methods:BE ACTIVE and OLE study design has been described previously.1 All OLE pts received BKZ 160 mg Q4W, irrespective of prior dosing regimen. Treatment-eme

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Xiang, L., A. Low, Y. Y. Leung, et al. "POS1413 INTERVAL BETWEEN SYMPTOM ONSET AND DIAGNOSIS AMONG PATIENTS WITH AUTOIMMUNE RHEUMATIC DISEASES IN A MULTI-ETHNIC ASIAN POPULATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 990.1–990. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1713.

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Background:The interval between symptom onset and diagnosis can often be longer than is ideal in autoimmune rheumatic diseases (ARDs).Objectives:We aimed to characterise this interval among patients newly diagnosed with ARDs in a multi-ethnic Asian population and to identify factors associated with a longer interval.Methods:We used Scott’s model of pathways to treatment to characterise the interval between symptom onset and diagnosis into 4 intervals: #1 between symptom onset and first seeking medical attention, #2 between first medical attention and rheumatology referral, #3 between rheumatol

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Van der Heijde, D., L. S. Gensler, A. Deodhar, et al. "OP0105 EFFICACY AND SAFETY OF BIMEKIZUMAB IN ANKYLOSING SPONDYLITIS: 48-WEEK PATIENT-REPORTED OUTCOMES FROM A PHASE 2B, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 68–69. http://dx.doi.org/10.1136/annrheumdis-2020-eular.323.

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Background:Bimekizumab (BKZ), a monoclonal antibody that selectively neutralises interleukin (IL)-17A and IL-17F, is a potential therapeutic option in ankylosing spondylitis (AS).Objectives:To report 48-week (wk) patient-reported outcomes (PROs) in patients (pts) with AS treated with BKZ in a phase 2b dose-ranging study (BE-AGILE;NCT02963506).Methods:Pts with active AS (Bath AS Disease Activity Index [BASDAI] ≥4; spinal pain ≥4 [0–10]), fulfilling modified New York criteria (central reading), and inadequate response/intolerance to NSAIDs were randomised according to the study design (Figure 1)

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Chee, Lynette C. Y., Jean Hendy, Louise Purton та Grant A. McArthur. "ATRA and the RARα Specific Agonist, NRX195183, Have Opposing Effects on the In Vitro Clonogenicity of Pre-Leukemic Murine AML1-ETO Bone Marrow Cells". Blood 116, № 21 (2010): 999. http://dx.doi.org/10.1182/blood.v116.21.999.999.

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Abstract Abstract 999 All-trans retinoic acid (ATRA) is used successfully to treat acute promyelocytic leukemia (APML), however, to date it has not shown promise in treating other AML subtypes. ATRA has been shown to enhance hematopoietic stem cell (HSC) self-renewal (requiring RARγ activation) but promotes differentiation of myeloid progenitors likely through RARα activation. We hypothesized that (1) the lack of success of ATRA in treating other AML subtypes may be due to the potential ability of ATRA to enhance self-renewal of the leukemic stem cell and (2) the use of a specific RARα agonist

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Ramiro, S., D. Poddubnyy, P. J. Mease, et al. "POS0247 RESOLUTION OF ENTHESITIS AND PERIPHERAL ARTHRITIS WITH BIMEKIZUMAB IN PATIENTS WITH AXIAL SPODYLOARTHRITIS: WEEK 52 RESULTS FROM THE BE MOBILE 1 AND BE MOBILE 2 PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 358–59. http://dx.doi.org/10.1136/annrheumdis-2023-eular.831.

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BackgroundA history of enthesitis or peripheral arthritis has been reported in >30% of patients (pts) with axial spondyloarthritis (axSpA),[1]both of which contribute to disease burden. Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, has demonstrated efficacy in phase 3 parallel studies in pts with non-radiographic (nr-)axSpA (BE MOBILE 1) and radiographic axSpA (r-axSpA i.e. ankylosing spondylitis; BE MOBILE 2).[2,3]ObjectivesTo evaluate the impact of BKZ on the main peripheral manifestations of axSpA, to Week (Wk) 52.Meth

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Sinha, Suresh Kumar, Mukteshwar Rajak, Prabhakar ., Rajneesh ., and Vivek Tripathi. "Spectrum of acute kidney injury in intensive care unit: a single centre experience." Indian Journal of Medical Sciences 69, no. 1 (2017): 44. http://dx.doi.org/10.18203/issn.0019-5359.indianjmedsci20170498.

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<p><span class="ABS_Bold-Italic" lang="en-GB">Background</span><span class="ABS_Bold-Italic" lang="en-GB">:</span><span> Acute kidney injury (AKI) in the intensive care unit (ICU) is associated with high mortality. A thorough understanding of the clinical spectrum of the disease is needed in order to device methods to improve the final outcome due to this problem. </span></p><p><span class="ABS_Bold-Italic" lang="en-GB">Aims and Objectives:</span><span> The aim of present study was to analyze the clinical spectrum, causes,

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Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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Aleksandrova, E., A. Novikov, P. Kulakova, et al. "AB1475 SERUM LEVELS OF INFLAMMATORY BOWEL DISEASE-SPECIFIC ANTIBODIES IN ANKYLOSING SPONDYLITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1843.1–1843. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2580.

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BackgroundAnkylosing spondylitis (AS) is an immune-mediated inflammatory disease of the musculoskeletal system, that is often accompanied with a subclinical intestinal inflammation. Inflammatory bowel diseases (IBD), including, Crohn’s disease (CD) and ulcerative colitis (UC), are the most frequent extra-articular manifestation in patients (pts) with AS. Several autoantibodies and antimicrobial antibodies are used as additional non-invasive serological markers for the diagnosis of CD and UC [1]. The evaluation of IBD-associated antibodies in AS pts provided conflicting results [2, 3].Objective

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Rodela, Helen, Zheng-Yi Yuan, John B. Hay, Dimitrios G. Oreopoulos, and Miles G. Johnston. "Reduced Lymphatic Drainage of Dialysate from the Peritoneal Cavity during Acute Peritonitis in Sheep." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 16, no. 2 (1996): 163–71. http://dx.doi.org/10.1177/089686089601600214.

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Objectives The purpose of this study was to investigate the effects of acute peritonitis on lymphatic drainage of the peritoneal cavity in conscious sheep Design Peritonitis was induced with the addition of 1% casein or 1% albumin to the dialysis solution. Thirty sheep (5 groups of 6) were used in this study. One group received 50 mL/kg intraperitoneal infusions of Dianeal 4.25% (486 mOsm/L); a second group received 1% casein-DianeaI4.25% (493 mOsm/L); a third group received 1% albumin-Dianeal 4.25% (487 mOsm/L). In the fourth and fifth groups (controls and casein-injected) lymph was collected

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McRae, Hannah L., Markus Horchler, Nadine Schwarz, et al. "Higher D-Dimer and Prothrombin Fragment 1+2 in Patients Taking Direct Oral Anticoagulants As Compared to Vitamin K Antagonists." Blood 144, Supplement 1 (2024): 1251. https://doi.org/10.1182/blood-2024-210238.

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Introduction: A central question regarding anticoagulant treatment of venous thromboembolism (VTE) is how long maintenance therapy should be continued. Current decision algorithms, which were developed during the era of vitamin K antagonists (VKA), are based on D-dimer measurements before and/or after discontinuation of anticoagulants. However, recent clinical data from the Apidulcis study questioned the validity of this approach in patients taking direct oral anticoagulants (DOACs). One reason for this may be generally higher D-dimer levels in patients on DOACs than in those on VKAs, for whic

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Deodhar, A., I. Mcinnes, X. Baraliakos, et al. "FRI0272 SECUKINUMAB DEMONSTRATES A CONSISTENT SAFETY PROFILE IN PATIENTS WITH PSORIASIS, PSORIATIC ARTHRITIS AND ANKYLOSING SPONDYLITIS OVER LONG TERM: UPDATED POOLED SAFETY ANALYSES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 722.2–722. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5118.

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Background:Pooled safety data has been reported with secukinumab (SEC) in patients (pts) with Psoriatic arthritis (PsA), Ankylosing Spondylitis (AS) and Psoriasis (PsO).1Objectives:To report longer-term safety data of SEC treatment in PsA, AS, PsO pts up to 5 years.Methods:The integrated clinical trial safety dataset included data pooled from 28 randomised controlled clinical trials of SEC 300 or 150 or 75 mg in PsO (11 Phase 3 and 8 Phase 4 trials), PsA (5 Phase 3 trials), and AS (4 Phase 3 trials), along with post-marketing safety surveillance data with a cut-off date of 25 December 2018. Ad

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Cordtz, R., S. Kristensen, R. Westermann, et al. "OP0173 INCIDENCE OF COVID-19 INFECTION AND HOSPITALISATION ACCORDING TO VACCINATION STATUS AND DMARD TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A NATIONWIDE MATCHED COHORT STUDY FROM DENMARK." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 114–15. http://dx.doi.org/10.1136/annrheumdis-2022-eular.349.

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BackgroundPatients with rheumatoid arthritis (RA) may have impaired immunogenicity to COVID-19 vaccines.ObjectivesTo investigate the incidence of COVID-19 infection and hospitalisation in unvaccinated and vaccinated patients with RA compared with matched individuals; and secondarily in patients with RA according to DMARD treatment.MethodsDanish nationwide matched cohort study from January to October 2021. Patients with RA were identified in DANBIO and matched 1:20 with individuals from the general population on age, sex, and vaccination status (month and exact type of vaccination). Primary and

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