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Journal articles on the topic '341.238: 347.823.12'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Ngari, Moses, Martha Mwangome, Nelson Ouma, et al. "Inpatient and postdischarge mortality among children with anaemia and malaria parasitaemia in Kenya: a cohort study." BMJ Global Health 9, no. 10 (2024): e016600. http://dx.doi.org/10.1136/bmjgh-2024-016600.

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BackgroundAnaemia and malaria are leading causes of paediatric hospitalisation and inpatient mortality in sub-Saharan Africa. However, there is limited empirical data on survival following hospital discharge. We aimed to estimate independent effects of anaemia and malaria parasitaemia on inpatient and 1 year postdischarge mortality among Kenyan children.MethodsA retrospective cohort study among children admitted to Kilifi County Hospital (KCH) from 2010 to 2019 and followed-up for 1 year postdischarge in Kilifi Health and Demographic Surveillance System (KHDSS). The main exposures were anaemia

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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos, and R. Chebel. "11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018." Reproduction, Fertility and Development 32, no. 2 (2020): 130. http://dx.doi.org/10.1071/rdv32n2ab11.

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Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis

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Michelena, X., S. S. Zhao, S. Dubash, G. T. Jones, L. Dean, and H. Marzo-Ortega. "FRI0287 BIOLOGIC DRUG RESPONSE DOES NOT APPEAR RELATED TO RADIOGRAPHIC STATUS IN AXIAL SPONDYLOARTHRITIS: DATA FROM THE BSRBR-AS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 732.2–732. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3147.

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Background:The concept of axial spondyloarthritis (axSpA) incorporates the full range of inflammatory spinal disease. In the absence of specific immuno-genetic biomarkers, classification criteria differentiate two groups (non-radiographic [nr-axSpA] and radiographic axSpA [r-axSpA]) based on the presence of structural damage of the sacroiliac joints. Controversy remains as to whether nr-axSpA represents a milder form with biologic DMARD (bDMARD) treatment restrictions still in place in many countries.Table 1.Baseline characteristics of nr-axSpA and r-axSpA patients starting biologics.Variables

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Ansaldi, Nicoletta, Tiziana Palmas, Andrea Corrias, et al. "Autoimmune Thyroid Disease and Celiac Disease in Children." Journal of Pediatric Gastroenterology and Nutrition 37, no. 1 (2003): 63–66. http://dx.doi.org/10.1002/j.1536-4801.2003.tb08105.x.

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ABSTRACTBackground:Celiac disease (CD) may be associated with other immunologic disorders in adults and children. Previous studies linking CD and autoimmune thyroid disease in children have included very few patients with limited biochemical and immunologic screening tests. The aim of this multicenter study was to establish the prevalence of autoimmune thyroid involvement in a large series of pediatric patients with CD.Methods:Five hundred seventy‐three consecutive pediatric patients were enrolled from clinics in Torino, Bologna, Foggia, Rome (two clinics), Naples, and Bari. Three hundred fort

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Smolen, J. S., T. Korotaeva, M. Nurmohamed, et al. "AB0530 EFFECT OF SKIN SYMPTOMS ON DISEASE IMPACT IN PATIENTS WITH PSORIATIC ARTHRITIS RECEIVING THE IL-12/23 INHIBITOR USTEKINUMAB OR TNF INHIBITORS IN THE REAL-WORLD PSABIO STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1295–96. http://dx.doi.org/10.1136/annrheumdis-2021-eular.767.

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Background:Psoriatic arthritis (PsA) is characterised by musculoskeletal symptoms, and patients (pts) with PsA usually experience psoriasis concurrently. Real-world data reflecting impact of skin symptoms on PsA disease burden are limited.Objectives:Analyse effectiveness of ustekinumab (UST) and tumour necrosis factor inhibitor (TNFi) therapy on extent of skin involvement, and the impact this has on PsA disease burden and drug persistence.Methods:PsABio (NCT02627768) is a prospective, observational study of 1st/2nd/3rd-line UST or TNFi treatment in PsA in 8 European countries. Extent of skin i

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Subedi, Deepak, Sumit Jyoti, Bhima Thapa, et al. "Knowledge, Attitude, and Practice of Antibiotic Use and Resistance among Poultry Farmers in Nepal." Antibiotics 12, no. 9 (2023): 1369. http://dx.doi.org/10.3390/antibiotics12091369.

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The abuse and misuse of antibiotics is one of the main drivers of antimicrobial resistance (AMR). Globally, AMR in food-producing animals is a significant public health concern. This study, therefore, assessed the knowledge, attitudes, and practices related to antibiotic usage (AMU) and AMR among poultry farmers in Nepal. We conducted a cross-sectional survey of 605 poultry farmers from six districts of Nepal from May to June 2022 to assess the status of knowledge, attitude, as well as practices toward prudent antibiotic usage (AMU) and AMR. The majority of the participants in our study were f

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McMullen, Carmit K., Marcia Grant, Christopher Wendel, et al. "Sexual function of long-term rectal cancer survivors." Journal of Clinical Oncology 34, no. 3_suppl (2016): 209. http://dx.doi.org/10.1200/jco.2016.34.3_suppl.209.

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209 Background: Many rectal cancer survivors report problems with intimacy and sexual function after surgery. The extent of these problems is not well known. Methods: Long-term rectal cancer survivors (5+ years post-diagnosis) who were members of Kaiser Permanente with permanent ostomy (n = 183) or sphincter-sparing surgery (N = 394) completed a mailed survey. Participants were identified through tumor registries and health plan data. Items from the City of Hope Quality of Life Colorectal Cancer scale assessed disruption to intimate relationships due to the surgery on a scale of 0-10, with 10

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Wu, Xiaofang, Chen Liping, Fenfen Dong, Wei Yan, Yuehua Shen, and Lei Ji. "Molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli Isolates from Patients and raw meat in Huzhou, China, 2021–2022." PLOS ONE 19, no. 12 (2024): e0311769. https://doi.org/10.1371/journal.pone.0311769.

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Background Campylobacter species are zoonotic pathogens, and are considered to be the major foodborne pathogen that causes outbreaks and sporadic gastrointestinal illnesses both in developed and developing countries. In this study, the molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli isolates from patients and raw meat between 2021 and 2022 in Huzhou were analyzed by using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST) and antimicrobial susceptibility testing. Methods From September 1, 2021 to December 31, 202

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Hoffmann-Vold, A. M., C. Brunborg, P. Airò, et al. "POS0063 PROGRESSIVE INTERSTITIAL LUNG DISEASE IS FREQUENT ALSO IN LATE DISEASE STAGES IN SYSTEMIC SCLEROSIS PATIENTS FROM EUSTAR." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 248. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4051.

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BackgroundShort disease duration is a predictor for progressive systemic sclerosis-associated interstitial lung disease (SSc-ILD), but studies assessing ILD progression in later disease stages are lacking. To individually tailor management of ILD in SSc patients in clinical practice it is, however, of high importance to understand disease behaviour also in patients with late disease.ObjectivesAnalyse ILD progression in SSc-ILD patients from the EUSTAR cohort segregated by subgroups of disease duration.MethodsWe segregated SSc-ILD patients into four categories of disease duration (≤3 years, &gt

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Samir, Rafla, Hamdy Sahar, Loutfy Mohamed, and Elneklawy Mohamed. "Correlation between the incidence and severity of Aortic Valve Calcific Stenosis and Carotid Atherosclerosis." Biolife 5, no. 4 (2022): 538–43. https://doi.org/10.5281/zenodo.7393117.

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<strong>ABSTRACT</strong> Background: Aortic valvular calcification (AVC) and carotid arterial disease (CaAD) have a high prevalence in elderly patients (pts). Aim of the work: To study the severity and relation of carotid plaques and coronary atherosclerotic lesions (CAD) in pts with calcific aortic sclerosis/stenosis. Methods: The study included 70 patients, 50 who had Aortic valve calcification (AVC) or stenosis, which was detected in TTE (systolic gradient more than 10 mmHg). The 20 other patients had Aortic valve thickening only or mild calcification (systolic gradient less than 10 mmHg).

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Sreeram, Aravind, Celine Yeh, Nicolas Toumbacaris, et al. "Association between adjuvant component of perioperative chemotherapy and survival outcomes in resected gastric cancer (GC)." Journal of Clinical Oncology 43, no. 4_suppl (2025): 378. https://doi.org/10.1200/jco.2025.43.4_suppl.378.

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378 Background: Perioperative chemotherapy is the standard of care for resectable GC but many patients do not proceed to or complete adjuvant chemotherapy (AC). It remains unclear whether AC following neoadjuvant chemotherapy (NAC) improves survival. Methods: Patients with GC who received NAC and underwent curative-intent gastrectomy from 2006-2022 were identified from an institutional database. Patients with mismatch repair-deficient/microsatellite instability-high tumors, GEJ tumors, M1 disease, neoadjuvant radiotherapy, total neoadjuvant intent treatment, incomplete NAC (<66% of planned

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Elbagir, S., L. M. Diaz-Gallo, G. Grosso, et al. "POS0747 ANTI-PHOSPHATIDYLSERINE/PROTHROMBIN ANTIBODIES AND VASCULAR EVENTS ASSOCIATE POSITIVELY WITH HLA-DRB1*13 AND NEGATIVELY WITH HLA-DRB1*03 IN SLE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 658.2–659. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2243.

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BackgroundAnti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) associate with thrombotic events (1). HLA-DRB1 alleles contribute to the occurrence of conventional antiphospholipid antibodies (aPL), including anti-beta2glycoprotein-I (beta2GPI) and anti-cardiolipin (CL) (2).ObjectivesWe investigated associations between anti-PS/PT and HLA-DRB1 alleles and thrombosis in patients with SLE. Conventional aPL were included for comparison.MethodsWe included 341 consecutive Swedish SLE patients, with information on general cardiovascular risk factors, including blood lipids, lupus anticoagulant

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Aringer, M., L. Arnaud, C. Peschken, et al. "POS0731 ASSOCIATION OF PATIENT-REPORTED OUTCOMES WITH TYPE I INTERFERON GENE SIGNATURE FROM THE INTERNATIONAL SYSTEMIC LUPUS ERYTHEMATOSUS PROSPECTIVE OBSERVATIONAL COHORT STUDY (SPOCS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 648–49. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1181.

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BackgroundThe aim of the Systemic Lupus Erythematosus Prospective Observational Cohort Study (SPOCS) is to examine the disease course of patients with systemic lupus erythematosus (SLE) in relation to their type I interferon gene signature (IFNGS) status.1 IFNGS has been associated with SLE disease activity.2ObjectivesTo identify associations between IFNGS status and patient-reported outcomes (PROs) among patients receiving clinical care while enrolled in SPOCS.MethodsThis noninterventional, international, prospective, observational cohort study included adult patients (≥18 years) with moderat

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Magro, Elena, Rosa Gonzalo-Daganzo, Trinidad Martin-Donaire, et al. "Single Unit Cord Blood Transplant Supported by Third Party Highly Purified Mobilized Hematopoietic Stem Cells: Immune Reconstitution Studies." Blood 108, no. 11 (2006): 311. http://dx.doi.org/10.1182/blood.v108.11.311.311.

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Abstract Background and Objectives: Following cord blood transplants (CBT) there is a period of severe and often prolonged immune deficiency that results in long term susceptibility to infections. Immune reconstitution is an important factor for long term survival. We analyzed the immune reconstitution of adult recipients of a single unit CBTs supported by a low number of third party donor highly purified mobilized hematopoietic stem cells (dual CB/TPD transplants), as previously described (Magro et al. Haematologica2006;91:640–8). This strategy results in transient double chimerism of CB and

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Lee, Junho, Daehwan Lee, Kiwon Lee, et al. "Abstract 7430: Multicenter study on an artificial intelligence model for predicting NSCLC recurrence." Cancer Research 85, no. 8_Supplement_1 (2025): 7430. https://doi.org/10.1158/1538-7445.am2025-7430.

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Abstract Background: Accurate and practical prediction of recurrence in early-stage NSCLC is essential for managing patient outcomes and tailoring personalized treatment strategies. This study updated and validated a previously developed transformer-based model for NSCLC recurrence prediction, which integrates clinical, pathological, laboratory, and radiologic data, while proposing strategies to enhance its generalizability. Methods: The model was developed and internally validated using data from Samsung Medical Center (SMC) and Kyung Hee University Hospital (KH) collected from 2008 to 2024.

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Guyader-Joly, C., B. Moulin, F. Mariller, et al. "443 BIOLOGICAL FACTORS AFFECTING OOCYTE COLLECTION AND EMBRYOS PRODUCTION IN A COMMERCIAL OVUM PICKUP-IVP SYSTEM IN HOLSTEIN AND MONTBELIARD BREEDS." Reproduction, Fertility and Development 22, no. 1 (2010): 378. http://dx.doi.org/10.1071/rdv22n1ab443.

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The aim of this work was to identify biological factors affecting oocyte collection, embryo production, and subsequent pregnancy rates through a retrospective study conducted from 381 commercial ovum pickup (OPU)-IVP sessions performed on high genetic Holstein and Montbeliard donors. Oocytes were retrieved using an ultrasound scanner SC 200 (Pie Medical, Maastricht, the Netherlands) equipped with a 7.5-MHz annular-array transducer. Donors were superovulated at Day 12 of presynchronized cycle with FSH (Stimufol®, Rhone-Merieux, Lyon, France) divided in 5 decreasing doses over 2.5 days. Cumulus-

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van der Hulle, T., P. L. den Exter, G. Meyer, et al. "Risk of Recurrent Venous Thromboembolism and Major Bleeding in Cancer-Associated Incidental Pulmonary Embolism Amongst Treated and Untreated Patients: A Pooled Analysis of 926 Patients." Blood 124, no. 21 (2014): 590. http://dx.doi.org/10.1182/blood.v124.21.590.590.

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Abstract Introduction Incidental pulmonary embolism (IPE) is defined as a pulmonary embolism diagnosed on a CT-scan performed for reasons other than a clinical suspicion of PE. Generally identified on staging scans, IPE has been estimated to occur in 3.1% of all cancer patients and is a growing challenge for clinicians and patients. Nevertheless, knowledge about the treatment and prognosis of cancer-associated IPE is scarce. In order to determine the outcome more accurately, and to identify clinical characteristics related to the prognosis, we pooled individual patient data from eleven observa

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Van der Heijde, D., L. S. Gensler, A. Deodhar, et al. "OP0105 EFFICACY AND SAFETY OF BIMEKIZUMAB IN ANKYLOSING SPONDYLITIS: 48-WEEK PATIENT-REPORTED OUTCOMES FROM A PHASE 2B, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 68–69. http://dx.doi.org/10.1136/annrheumdis-2020-eular.323.

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Background:Bimekizumab (BKZ), a monoclonal antibody that selectively neutralises interleukin (IL)-17A and IL-17F, is a potential therapeutic option in ankylosing spondylitis (AS).Objectives:To report 48-week (wk) patient-reported outcomes (PROs) in patients (pts) with AS treated with BKZ in a phase 2b dose-ranging study (BE-AGILE;NCT02963506).Methods:Pts with active AS (Bath AS Disease Activity Index [BASDAI] ≥4; spinal pain ≥4 [0–10]), fulfilling modified New York criteria (central reading), and inadequate response/intolerance to NSAIDs were randomised according to the study design (Figure 1)

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Chivers, Bonnie R., Rhonda M. Garad, Jacqueline A. Boyle, Helen Skouteris, Helena J. Teede, and Cheryce L. Harrison. "Perinatal Distress During COVID-19: Thematic Analysis of an Online Parenting Forum." Journal of Medical Internet Research 22, no. 9 (2020): e22002. http://dx.doi.org/10.2196/22002.

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Background The COVID-19 global pandemic has impacted the whole of society, requiring rapid implementation of individual-, population-, and system-level public health responses to contain and reduce the spread of infection. Women in the perinatal period (pregnant, birthing, and postpartum) have unique and timely needs for directives on health, safety, and risk aversion during periods of isolation and physical distancing for themselves, their child or children, and other family members. In addition, they are a vulnerable group at increased risk of psychological distress that may be exacerbated i

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Gharaibeh, M., N. Smith, S. Jeyakumar, E. Mark, and S. Shreay. "SAT0142 MATCHING ADJUSTED INDIRECT COMPARISON OF FILGOTINIB VS. TOFACITINIB IN MODERATE-TO-SEVERE ACTIVE RHEUMATOID ARTHRITIS PATIENTS WITH INADEQUATE RESPONSE TO METHOTREXATE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1009–10. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6108.

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Background:Filgotinib (FILG) is a JAK1 inhibitor that has been investigated in combination with methotrexate (MTX) for the treatment of moderate-to-severe rheumatoid arthritis (RA). To date, no head-to-head trial has compared the efficacy of FILG versus tofacitinib (TOFA).Objectives:To compare the efficacy of FILG 200 mg + MTX with TOFA 5 mg + MTX using matching adjusted indirect comparison (MAIC).Methods:MAIC technique uses individual patient data (IPD) from one trial and aggregate data from the other to enable comparison of outcomes after matching on baseline characteristics [1]. An anchored

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Robertson, W. R., B. Davison, D. C. Anderson, J. Frost, and A. Lambert. "Effect of adrenocorticotrophin on cortisol and androstenedione secretion from dispersed cells of guinea-pig adrenal zonae fasciculata and reticularis." Journal of Endocrinology 109, no. 3 (1986): 399–404. http://dx.doi.org/10.1677/joe.0.1090399.

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ABSTRACT We have studied cortisol and androstenedione secretion by dispersed cells of the outer zona fasciculata (ZF) plus zona glomerulosa, and the inner zona reticularis (ZR) plus medulla of the guinea-pig adrenal. The ZF and ZR were microdissected apart, the cells dispersed and incubated (200 000 cells/ml) for 90 min in the presence of adrenocorticotrophin (ACTH; 500 ng/l), dibutyryl cyclic AMP (dbcAMP; 1 mmol/l), pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 11-deoxycortisol and 21-deoxycortisol. The steroid concentrations were 5–25 μmol/l. Cortisol secretion was assayed by

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Baker-Smith, Carissa M., Wei Yang, Mary J. McDuffie, et al. "Association of Area Deprivation With Primary Hypertension Diagnosis Among Youth Medicaid Recipients in Delaware." JAMA Network Open 6, no. 3 (2023): e233012. http://dx.doi.org/10.1001/jamanetworkopen.2023.3012.

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ImportanceThe association between degree of neighborhood deprivation and primary hypertension diagnosis in youth remains understudied.ObjectiveTo assess the association between neighborhood measures of deprivation and primary hypertension diagnosis in youth.Design, Setting, and ParticipantsThis cross-sectional study included 65 452 Delaware Medicaid-insured youths aged 8 to 18 years between January 1, 2014, and December 31, 2019. Residence was geocoded by national area deprivation index (ADI).ExposuresHigher area deprivation.Main Outcomes and MeasuresThe main outcome was primary hypertension d

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Beckers, Marielle M. J., Roger E. G. Schutgens, Martin H. Prins, and Douwe H. Biesma. "Prevalence and Characteristics of Occult Cancer in Patients with Venous Thromboembolism." Blood 106, no. 11 (2005): 1623. http://dx.doi.org/10.1182/blood.v106.11.1623.1623.

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Abstract Background: Venous thromboembolism (VTE) can be the first sign of occult cancer. It is still a matter of debate if screening programs for cancer should be encouraged. No one would advocate extensive screening in an at random VTE-population. It is, however, possible that a subgroup of VTE-patients has a relatively high risk for developing cancer. Objective: To identify a group of patients with a high prevalence of cancer during follow-up (occult cancer). Results: We retrospectively reviewed the prevalence and type of cancer in 610 consecutive VTE-patients (267 men and 343 women). Mean

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Chang, Ying-Jun, Dai-Hong Liu, Kaiyan Liu, et al. "Effects Of Noninherited Maternal Antigen On The Occurrence Of Acute Graft-Versus Host Diseae After Unmanipulated Haploidentical Blood and Marrow Transplantation." Blood 122, no. 21 (2013): 3301. http://dx.doi.org/10.1182/blood.v122.21.3301.3301.

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Abstract Background Exposure to non-inherited maternal antigen (NIMA) in fetal and neonatal life has a lifelong immunological consequence. In haploidentical transplantation, the mismatched haplotype of the donor can originate from either the mother or the father. The aim of this prospective study is to investigate the effects of NIMA and non-inherited paternal antigen (NIPA) on transplant outcomes in patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT). Methods Two hundred and eleven patients with hematological disease, including AML, ALL, CML, MDS, SAA,

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Mukhtarova, Ziyafat. "Фазовые равновесия в системе Sm2Te3–GeTe". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, № 2 (2019): 328–33. http://dx.doi.org/10.17308/kcmf.2019.21/770.

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Методами физико-химического анализа – дифференциально-термическим, высокотемпературным дифференциально-термическим, рентгенофазовым, микроструктурным, а также измерением микротвердости изучена система Sm2Te3–GeTe, которая является квазибинарным сечением тройной системы Ge–Sm–Te. При соотношении исходных теллуридов 1:1 (50 мол. %) и температуре 1100 К по перитектической реакции ж+Sm2Te3→ GeSm2Te4 образуется тройное соединение GeSm2Te4. Образцы системы, богатые GeTe, представляют собой компактные слитки блестяще-серого цвета, а сплавы, бо-гатые Sm2Te3 – спек черного цвета. Ликвидус системы Sm2Te

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Couture, A. A., N. Carrier, S. Roux, H. Allard-Chamard, P. Liang, and G. Boire. "POS0467 DISCORDANCE IN PATIENT AND EVALUATOR GLOBAL ASSESSMENT OF DISEASE ACTIVITY OVER TIME AND ACROSS DISEASE ACTIVITY LEVELS IN RECENT-ONSET RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 492.1–492. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1854.

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BackgroundTreatment of rheumatoid arthritis (RA) aims to achieve remission or at least low disease activity. Composite measures (e.g. SDAI) to measure RA disease activity usually incorporate patient (PGA) and evaluator (EGA) global assessments. EGA and PGA are often discordant, reflecting divergences in evaluation of disease impact and potentially towards therapeutic goals.ObjectivesPatient vs Physician (PGA – EGA) discordance was evaluated according to disease duration over 5 years and to concomitant SDAI scores.MethodsDemographics, clinical and serological variables, radiographic damage (Sha

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Mariette, X., S. Borchmann, S. Aspeslagh, et al. "POS0824 CARDIOVASCULAR (CV) AND MALIGNANCY EVENTS IN THE FILGOTINIB (FIL) RHEUMATOID ARTHRITIS (RA) CLINICAL DEVELOPMENT PROGRAM UP TO 8.3 YEARS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 707.1–708. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1425.

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BackgroundFIL is a Janus kinase (JAK) 1 preferential inhibitor for the treatment of RA. Data from the ORAL Surveillance post-marketing study (NCT02092467) suggest that in patients with active RA aged ≥50 years with ≥1 CV risk factor, the risks of cancer and major adverse cardiovascular events (MACE) are higher with the pan-JAK inhibitor tofacitinib vs tumor necrosis factor inhibitors, with higher rates in those aged ≥65 vs <65 years.[1]ObjectivesTo assess the incidence of malignancies excluding non-melanoma skin cancer (NMSC), NMSC, MACE and venous thromboembolism (VTE) in patients treated

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Styczynski, Jan, and Lidia Gil. "Prevention and Treatment of EBV-PTLD in HSCT Recipients: A Systematic Review Based on ECIL-2 Recommendations." Blood 112, no. 11 (2008): 4356. http://dx.doi.org/10.1182/blood.v112.11.4356.4356.

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Abstract INTRODUCTION: The rate of death due to EBV posttransplant lymphoproliferative disorder (EBV-PTLD) in the long-term analysis of 18,014 patients from 234 transplant centers was 66/78 (84.6%) up to 1999 (Curtis RE et al, Blood, 1999). OBJECTIVE: To evaluate the role of available treatment modalities for prevention and treatment of EBV-PTLD in HSCT recipients, based on ECIL-2 recommendations. DATA SOURCES: A PubMed search (1999–2008) was conducted using the key words EBV, PTLD, posttransplant lymphoproliferative disorder, stem cell transplantation, rituximab, CTL, cytotoxic lymphocytes, i

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Penka, Miroslav, Jiri Schwarz, Michael Doubek, et al. "JAK2 Mutation and Additional Thrombophilic Markers Predispose to Thrombosis in Myeloproliferative Diseases with Thrombocythemia." Blood 112, no. 11 (2008): 5257. http://dx.doi.org/10.1182/blood.v112.11.5257.5257.

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Abstract OBJECTIVES: Bleeding and thrombotic events are common complications symptoms in myeloproliferative diseases with thrombocythemia (MPD-T). The increased platelet count need not be the only cause of them. In the current study we have evaluated prospectively collected data of 421 Czech patients from an international registry of patients treated with anagrelide (ANG) with the aim to check whether JAK2 V617F mutation or additional thrombophilic states predispose to thrombosis in MPD-T. PATIENTS: The initial diagnoses (recorded largely according to PVSG criteria) were the following: essenti

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Rojas Zuleta, W. G., M. Barbosa, C. Becerra-Arias, et al. "AB0438 TAPERING BIOLOGICAL DMARD IN RHEUMATOID ARTHRITIS: REAL-WORLD EVIDENCE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1407.1–1408. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1214.

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Backgroundbiological DMARDs have revolutionized the treatment of rheumatoid arthritis (RA), demonstrating effectiveness in terms of symptom control, improvement in quality of life and radiographic progression. However, their high-cost impacts global health systems. Therefore, tapering strategies are important therapeutic strategies to consider in patients with sustained remission. It is estimated that up to 50% of patients with bDMARDs and sustained response would be successful upon biologic therapy optimization [1].Objectivesto estimate the relapse rate in patients with RA on tapering bDMARD

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Listowski, Maciej. "The Role of Standard and Supplementary Observers in Accurate Illuminance measurements." Photonics Letters of Poland 16, no. 3 (2024): 52–54. http://dx.doi.org/10.4302/plp.v16i3.1286.

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Typically the sensitivity V2 (λ) for a 2° standard observer is used at photometric measurments. Nevertheless, the light reach the human eye from wider field of view. This fact motivated the International Commission on Illumination to introduce the 10° supplementary observer with sensitivity V10 (λ). This paper analyzes the impact of transition from V2 (λ) to V10 (λ) on measured pc-LEDs illuminance values. The results indicate that the maximum difference is 2% for 3000 K pc-LEDs, 4% for 4000 K pc-LEDs, and 6% for 6500 K pc LEDs. Full Text: PDF References K.S. Gibson, E.P.T. Tyndall, "Visibility

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Falchi, Lorenzo, Michael J. Keating, Susan Lerner, et al. "Other Cancers in Patients with Chronic Lymphocytic Leukemia Requiring Therapy: Association with Prognostic Factors and Impact On Survival." Blood 120, no. 21 (2012): 3896. http://dx.doi.org/10.1182/blood.v120.21.3896.3896.

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Abstract Abstract 3896 Chronic lymphocytic leukemia (CLL) is associated with an increased incidence of other cancers (OC). Potential risk factors for OC in CLL include immune disturbances, shared risk factors, genetic predisposition and chemotherapy. While reports on OC in patients with CLL have been typically descriptive in nature, detailed information regarding the clinical features of OC, relationship with the time of diagnosis of CLL, patient characteristics, prognostic factors and survival have been missing. We report an analysis of OC in pts with CLL requiring therapy, with a post therap

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Mouehla, Hanif, Maya Siegel, Edo Schaefer, et al. "Fertility and Sexual Development Outcomes in Pubertal and Post-Pubertal Children and Young Adults after Myeloablative Conditioning (MAC) and Familial Haploidentical T-Cell Depleted Allogeneic Stem Cell Transplantation." Blood 144, Supplement 1 (2024): 7393. https://doi.org/10.1182/blood-2024-208814.

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Background: Sickle cell disease (SCD) leads to chronic end-organ damage and reduced life span. Advancements in transplantation protocols and graft manipulation have enabled the use of other allogeneic donor sources as a curative measure for high-risk patients. We previously reported the safety and efficacy of familial haploidentical transplants (FHI) in pediatric SCD population with 100% engraftment (Cairo et al, JAMA Peds, 2020). Traditional myeloablative conditioning (MAC) regimens are considered necessary to improve engraftment but may lead to severe long-term effects such as infertility an

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Guglielmelli, Paola, Giada Rotunno, Annalisa Pacilli, et al. "Prognostic Impact of Bone Marrow Fibrosis in Primary Myelofibrosis: A Study of Agimm Group on 540 Patients." Blood 126, no. 23 (2015): 351. http://dx.doi.org/10.1182/blood.v126.23.351.351.

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Abstract Background. The prognostic significance of bone marrow (BM) fibrosis grade in pts with primary myelofibrosis (PMF) is debated. A fibrosis grade greater than 1 was associated with a 2-fold higher risk of death compared with pts with early/prefibrotic MF (grade 0) [Thiele J, Ann Hematol 2006]. Recent data suggest that more accurate prediction of survival is achieved when fibrosis grade is added to IPSS [Verner C, Blood 2008; Giannelli U, Mod Pathol 2012]. Aim. To analyze the prognostic impact of fibrosis in diagnostic BM samples of 540 WHO-2008 diagnosed PMF pts with extensive clinical

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K., Ramaiah, Sivasankar R., Sreenivasulu G., et al. "Significance of red grape extract on oxidative enzymes in the brain of male albino rat with reference to aging." Biolife 3, no. 2 (2022): 451–60. https://doi.org/10.5281/zenodo.7269502.

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<strong>ABSTRACT</strong> Nicotine has been reported to induce oxidative stress by producing the Reactive Oxygen Species (ROS). In vitro studies showed that Red grape extract has significant antioxidant activity and can inhibit oxidation. Pathogen free, Wistar strain male albino rats were used in the present study, rats were divided into 4 groups of six rats in each group and treated as follows: Group I. Normal Control (NC) (Control rats received 0.9% saline). Group II. Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months). Group III. Re

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Divya, Teja D., and Vardhani Viveka. "Influence of Gene Vac B vaccine on the abdominal muscle MDA in the immunostimulated male swiss albino mice." Biolife 4, no. 1 (2022): 68–73. https://doi.org/10.5281/zenodo.7309976.

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<strong>ABSTRACT</strong> Malondialdehyde (MDA) is a naturally occurring product of lipid peroxidation, initiated by free radicals (causing oxidative stress by reactive oxygen species - ROS). MDA is highly mutagenic and carcinogenic and plays a significant role in disease pathogenesis by disturbing the immune response and forms immune complexes that may be deposited in various tissues. This study is centralized on the immunostimulatory effect of Immunex DS (IDS) on the MDA level in abdominal muscle tissue of mice against Gene Vac B vaccine. Eight groups of male swiss albino mice (10 in each) w

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Witte, T., U. Kiltz, F. Haas, et al. "AB0255 BASELINE CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH UPADACITINIB IN GERMAN REAL-WORLD PRACTICE: RESULTS FROM THE POST-MARKETING OBSERVATIONAL UPwArds STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1153.2–1154. http://dx.doi.org/10.1136/annrheumdis-2021-eular.886.

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Background:The efficacy and safety of upadacitinib (UPA), a selective Janus kinase inhibitor, has been evaluated in the SELECT rheumatoid arthritis (RA) clinical program,1–6 but its real-world effectiveness remains to be investigated. The UPwArds study will assess the association of C-reactive protein (CRP) level with remission and other efficacy outcomes in patients with RA treated with UPA in German real-world practice.Objectives:To describe the baseline characteristics of patients enrolled in the UPwArds study.Methods:The prospective, open-label, multicenter, non-interventional, post-market

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Zimmer, A., A. Klein, F. Dressler, et al. "OP0163 GOLIMUMAB FOR THE TREATMENT OF POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS – AN UPDATE ON SAFETY AND EFFECTIVENESS FROM THE BIKER REGISTRY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 108.1–108. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3785.

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BackgroundGolimumab (GOL) is approved for treatment of polyarticular juvenile idiopathic arthritis (pJIA) in patients 2 years and older. Data on long-term safety of GOL in this indication are limited.ObjectivesTo assess long-term safety and effectiveness of GOL in pJIA patients.MethodsIn this ongoing non-interventional observational study, clinical characteristics, disease activity and safety parameters were analysed using the German Biologics in Paediatric Rheumatology (BiKeR) registry. A total of 141 pJIA-patients treated with GOL were frequency matched by body weight with 282 patients recei

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Dibyendu, Talukdar. "Arsenic bioaccumulation and tolerance in terrestrial fern Ampelopteris prolifera (Retz.) Copel and aquatic fern, Azolla pinnata R. Br. are related to coordinated but differential responses of their antioxidant defense components." Biolife 4, no. 3 (2022): 460–70. https://doi.org/10.5281/zenodo.7321839.

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<strong>ABSTRACT</strong> Present study aims to analyze the arsenate bioaccumulation and antioxidant defense responses in fronds of terrestrial fern <em>Ampelopteris prolifera</em> (Retz.) Copel and an aquatic fern <em>Azolla pinnata</em> R. Br. Both the ferns were exposed to increased concentrations of sodium arsenate (As; 0, 20, 60, 100, and 160 mg L<sup>-1</sup>) with Hoagland nutrient solution. Shoot dry weight reduced in both ferns at 160 mg As L<sup>-1</sup> with higher decline in <em>A. pinnata</em> than <em>A. prolifera</em>. Fronds accumulated considerably higher As than roots but, co

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Mulrooney, E., T. Neogi, H. Solveig Dagfinrud, et al. "OP0199 HAND OSTEOARTHRITIS PHENOTYPES AND THEIR ASSOCIATIONS WITH PAIN AND CHANGE IN PAIN." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 131.2–132. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3013.

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BackgroundHand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Different pain patterns may be explained by underlying phenotypes, which previously have not been explored.ObjectivesUsing the biopsychosocial framework, we aimed to identify possible hand OA phenotypes and explore the associations with pain intensity and change in pain during a four-year follow-up.MethodsLatent class analysis was used to determine classes of people with hand OA, based on baseline examination (2016-17), followed by posterior fit statistics. Biological, psychological, and social domain

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Zanwar, Saurabh, Jithma Prasad Abeykoon, Stephen M. Ansell, et al. "Prognosis of Patients with Waldenström Macroglobulinemia: A Simplified Model." Blood 132, Supplement 1 (2018): 4152. http://dx.doi.org/10.1182/blood-2018-99-119849.

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Abstract Background: Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma with a heterogeneous disease course. For nearly a decade, the International Prognostic Scoring system (IPSS), requiring 5 variables (platelet count, hemoglobin, age, Beta 2 microglobulin and immunoglobulin M size) has been used to prognosticate patients with active WM. In this study, we attempt to propose a simplified prognostic model for patients with active/symptomatic WM. Methods: All patients with active WM diagnosed between 01/01/1996 and 12/31/2017 and evaluated consecutively at Mayo Clinic, Rochester

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Faical, Boutlib, M.F. Deman Camille, Tahouri Jad, and Guemmouh Raja. "Anthropogenic Actions on Population Density of the Barbary Macaques in Eastern Middle Atlas, Morocco." Biolife 6, no. 3 (2022): 1–14. https://doi.org/10.5281/zenodo.7403053.

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<strong>ABSTRACT</strong> The Barbary Macaque (Macaca sylvanus) lives in the forest biotopes of Algeria and Morocco. It is found mostly in the cedar forests of the Middle Atlas Mountains, where it lives in structured groups. In the Eastern Middle Atlas, in addition to cedar forests, it also lives on rocky outcrops. In these places, the groups are not isolated by habitat degradation and caves are used as dormitories. In the Eastern Middle Atlas, we counted the existing monkeys by a simple scan. The study showed that the remaining populations of monkeys have a large turnover of individuals. We s

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Khan, Muhammad Hamza. "influence of green HRM practices and green knowledge sharing on green service behaviors." Inverge Journal of Social Sciences 2, no. 2 (2023): 176–93. https://doi.org/10.63544/ijss.v2i2.40.

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Purpose: The aim of this study is to investigate the relationship between green knowledge sharing and green human resource management on green service behaviors in banks. Design/Methodology/Approach: Partial least-squares analysis is used to examine the opinions of 102 frontline bank workers in Pakistan. Research Limitations/Implications: Because this study focuses on the attitudes among employees of private commercial banking organizations, its conclusions cannot be generalized to all other service organizations in Pakistan. Practical Implication: This research shows that green human resource

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Anasse, NOUNSI, OUTCOUMIT Ali, TALBI Zouheir, et al. "Effect of endomycorrhizal inoculation on the growth of Eucalyptus plants." Biolife 3, no. 3 (2022): 583–94. https://doi.org/10.5281/zenodo.7272865.

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<strong>ABSTRACT</strong> The aim of this work is to study the effect of a composite endomycorrhizal inoculum on growth of Eucalyptus plants (<em>E. gomphocephala</em>) in the nurseries conditions. Analysis of the results, four months after inoculation, revealed that all roots were mycorrhizal and different structures characterizing arbuscular endomycorrhizal fungi were observed. The mycorrhizal frequency and intensity of Eucalyptus roots are 90 and 25% respectively. This roots endomycorrhization was accompanied by a significant improvement on growth parameters of mycorrhized Eucalyptus plants

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Wesseling, Jelle. "Abstract F1-2: Clonal evolution of DCIS to invasion." Cancer Research 83, no. 5_Supplement (2023): F1–2—F1–2. http://dx.doi.org/10.1158/1538-7445.sabcs22-f1-2.

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Abstract Clonal evolution of DCIS to invasion Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive breast cancer (IBC). If not treated, at least 3 out of 4 women with DCIS will not develop IBC1-3. This implies many women with non-progressive, low-risk DCIS are likely to carry the burden of overtreatment. To solve this DCIS dilemma, two fundamental questions need to be answered. The first question is, how the subsequent IBC is related to the initial DCIS lesion. The seco

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Hidayatulloh, Taufik, Elindra Yetti, and Hapidin. "Movement and Song Idiom Traditional to Enhance Early Mathematical Skills: Gelantram Audio-visual Learning Media." JPUD - Jurnal Pendidikan Usia Dini 14, no. 2 (2020): 215–30. http://dx.doi.org/10.21009/jpud.142.02.

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Many studies have shown a link between being competent in early mathematics and achievement in school. Early math skills have the potential to be the best predictors of later performance in reading and mathematics. Movement and songs are activities that children like, making it easier for teachers to apply mathematical concepts through this method. This study aims to develop audio-visual learning media in the form of songs with a mixture of western and traditional musical idioms, accompanied by movements that represent some of the teaching of early mathematics concepts. The stages of developin

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Evangelin, G., Horne Bertrand, M. Muthupandi, and William S. John. "VENOMOUS SALIVA OF NON-HAEMATOPHAGOUS REDUVIID BUGS (HETEROPTERA: REDUVIIDAE): A REVIEW." Biolife 2, no. 2 (2022): 615–26. https://doi.org/10.5281/zenodo.7214084.

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<strong>ABSTRACT</strong> While reduviids are a modestly well characterized group of insects, especially the blood sucking triatominae due to the medical implications of the Chagas disease, which is mainly transmitted by the infected bugs whose excrement contains <em>Trypanosoma cruzi </em>that enters the body through bruises or cuts in the skin of humans, their non-haematophagus counterparts are a forgotten lot and have not been thoroughly investigated. The venom in the saliva of the non-haematophagus reduviids has come into the spotlight in the last couple of decades due to the voracious pre

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Мингазов, Шамиль Рафхатович. "БУЛГАРСКИЕ РЫЦАРИ ЛАНГОБАРДСКОГО КОРОЛЕВСТВА". Археология Евразийских степей, № 6 (20 грудня 2020): 132–56. http://dx.doi.org/10.24852/2587-6112.2020.6.132.156.

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Настоящая работа является первым общим описанием на русском языке двух некрополей Кампокиаро (Кампобассо, Италия) – Виченне и Морионе, датируемых последней третью VII в. – началом VIII в. Культурное содержание некрополей показывает прочные связи с населением центральноазиатского происхождения. Важнейшим признаком некрополей являются захоронения с конем, соответствующие евразийскому кочевому погребальному обряду. Автор поддержал выводы европейских исследователей о том, что с большой долей вероятности некрополи оставлены булгарами дукса–гаштальда Алзеко, зафиксированными Павлом Диаконом в VIII в

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Yakubu, Bashir Ishaku, Shua’ib Musa Hassan, and Sallau Osisiemo Asiribo. "AN ASSESSMENT OF SPATIAL VARIATION OF LAND SURFACE CHARACTERISTICS OF MINNA, NIGER STATE NIGERIA FOR SUSTAINABLE URBANIZATION USING GEOSPATIAL TECHNIQUES." Geosfera Indonesia 3, no. 2 (2018): 27. http://dx.doi.org/10.19184/geosi.v3i2.7934.

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Rapid urbanization rates impact significantly on the nature of Land Cover patterns of the environment, which has been evident in the depletion of vegetal reserves and in general modifying the human climatic systems (Henderson, et al., 2017; Kumar, Masago, Mishra, & Fukushi, 2018; Luo and Lau, 2017). This study explores remote sensing classification technique and other auxiliary data to determine LULCC for a period of 50 years (1967-2016). The LULCC types identified were quantitatively evaluated using the change detection approach from results of maximum likelihood classification algorithm

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