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Yadav, Raj Singh, Ankur Dahayat, Naseer Mohammad, Fatima Shirin, and Harshita Agrahari. "Evaluation of Five DNA Extraction Methods for Dillenia pentagyna Roxb. and Hardwickia binata Roxb. Suitable for PCR Amplification." International Journal of Applied Sciences and Biotechnology 12, no. 2 (June 28, 2024): 54–61. http://dx.doi.org/10.3126/ijasbt.v12i2.64794.
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High-quality genomic DNA extraction is crucial for the conservation of forest genetic resources, particularly for endangered species like Dillenia pentagyna Roxb. (Karmal) and Hardwickia binata Roxb. (Anjan), which hold significant value in traditional medicine and economics. The presence of contaminants such as polysaccharides, polyphenols, and secondary metabolites in forest trees complicates the isolation of sufficient, uncontaminated DNA. In this study, we evaluated five DNA extraction protocols, including those by Doyle and Doyle (1990), Michiels et al., (2003), Porebski et al., (1997), Khanuja et al., (1999), and Deshmukh et al., (2007). Quantification and quality analysis of the extracted DNA were conducted using a Nanodrop spectrophotometer and Agarose Gel Electrophoresis. Notably, minor modifications to the CTAB-based method outlined by Doyle and Doyle (1990) significantly enhanced DNA quality. The absorbance ratio at 260/280nm indicated mean purity ratios of 1.62 for D. pentagyna and 1.7 for H. binata, with DNA concentrations recorded at 341.6 μg/ml and 317.72 μg/ml, respectively. The Doyle and Doyle (1990) method consistently produced high-quality DNA, devoid of contaminants. Subsequent PCR amplification with SSR primers confirmed the suitability of the extracted DNA, exhibiting distinct and well-defined bands. Int. J. Appl. Sci. Biotechnol. Vol 12(2): 54-61.
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Mohammed Qasim Al Nuwaini, Giyathaldeen T. Neameh, Mustafa A. Al Zubaidi Md, and Farook M. Albusultan. "Effect of intravitreal Triamcinolone (2mg) on diabetic macular oedema in the pseudophakic patient as primary treatment." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 17, 2020): 3533–39. http://dx.doi.org/10.26452/ijrps.v11i3.2507.
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Diabetic macular oedema is still a significant cause of vision drop in the diabetic patient with no definitive regime for treatment. This study was on the result of effects of intravitreal injection of (2mg) triamcinolone on central macular thickness measured by OCT, visual acuity and intraocular pressure in pseudophakic eyes with diabetic macular oedema as a primary treatment line followed in six months. This study is a prospective, interventional case study series. It was on patients who received intravitreal injection of Triamcinolone in a single dose of ( 2 mg/0. 05 ml). Central macular thickness by OCT, visual acuity, and intraocular pressure was measured pre-injection and 1,3,6 months after injection. This study was performed in Iraq, Baghdad, Ibn Al-Haitham Teaching Eye Hospital from October 2014 to July 2015. Results showed 25 eyes received intravitreal injection of Triamcinolone Acetoniod with pre-injection central macular thickness 597.9+98.02 µm, visual acuity 1.096+0.61 Log MAR and intraocular pressure of 16.5+ 2.53 mmHg. After six months of follow up on central macular thickness 341.6+163.1 µm, visual acuity was 0.63 + 0.40 Log MAR and IOP was 18. 04+ 5. 63mmHg. This study suggests that intravitreal injection of Triamcinolone in a dose 2mg / 0. 05ml improves both anatomical and visual outcome in 21 eyes (84%) out of 25 pseudophakic eyes with diabetic macular oedema during first six months after injection and an increase in intraocular pressure in 2 eyes (8%). The intraocular pressure was despite the use of anti-glaucoma medications during this period.
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Cortés-Pérez, Melquiades, Fernando De León-González, Fernando Paz-Pellat, Tania Leyva-Pablo, Wenceslao Santiago-García, Alejandro Ponce-Mendoza, and Mariela Fuentes Ponce. "Almacenamiento de carbono aéreo en un bosque templado de Oaxaca: manejo de alta y baja intensidad." Madera y Bosques 27, no. 4 (December 2, 2021): e2742440. http://dx.doi.org/10.21829/myb.2021.2742440.
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El manejo forestal sustentable es una alternativa para conservar la biodiversidad, mantener la estructura forestal y, por ende, el almacenamiento de carbono. El objetivo del presente trabajo fue determinar el efecto del manejo forestal sobre la diversidad y estructura de las especies arbóreas y cuantificar el contenido de carbono almacenado en la biomasa aérea de bosques templados en tres sistemas: (1) método mexicano de ordenación de bosques irregulares (MMOBI), (2) método de desarrollo silvícola (MDS) y (3) bosque no manejado (BNM), ubicados en Santiago Xiacuí y Santiago Comaltepec, Oaxaca, México. Para estimar la diversidad arbórea se utilizaron índices alfa. La estructura se evaluó a partir del índice de valor de importancia (IVI). El carbono almacenado en la biomasa se estimó con datos dasométricos y ecuaciones volumétricas. Se identificaron 44 especies distribuidas en 14 familias. De acuerdo con el IVI, las especies más importantes en los tres sistemas fueron Q. laurina Humb. & Bonpl. y P. patula Schiede ex Schltdl. & Cham. presentando los mayores contenidos de carbono. El sistema forestal con mayor contenido de carbono en la biomasa fue el BNM (341.6 Mg ha-1 de biomasa y 164.7 Mg ha-1 de contenido de carbono), además de presentar la densidad más alta (872 árboles ha-1). Los bosques manejados con el MMOBI tienen mayor potencial de almacenamiento de carbono respecto a los MDS, debido a que tienen mayor similitud en diversidad y densidad que un bosque no manejado.
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McDermott, Mary M., Lydia Bazzano, Charlotte A. Peterson, Robert Sufit, Luigi Ferrucci, Kathryn Domanchuk, Lihui Zhao, et al. "Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease." JAMA 328, no. 13 (October 4, 2022): 1315. http://dx.doi.org/10.1001/jama.2022.16797.
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ImportancePatients with lower extremity peripheral artery disease (PAD) have reduced lower extremity perfusion, impaired lower extremity skeletal muscle function, and poor walking performance. Telmisartan (an angiotensin receptor blocker) has properties that reverse these abnormalities.ObjectiveTo determine whether telmisartan improves 6-minute walk distance, compared with placebo, in patients with lower extremity PAD at 6-month follow-up.Design, Setting, and ParticipantsDouble-blind, randomized clinical trial conducted at 2 US sites and involving 114 participants. Enrollment occurred between December 28, 2015, and November 9, 2021. Final follow-up occurred on May 6, 2022.InterventionsThe trial randomized patients using a 2 × 2 factorial design to compare the effects of telmisartan plus supervised exercise vs telmisartan alone and supervised exercise alone and to compare telmisartan alone vs placebo. Participants with PAD were randomized to 1 of 4 groups: telmisartan plus exercise (n = 30), telmisartan plus attention control (n = 29), placebo plus exercise (n = 28), or placebo plus attention control (n = 27) for 6 months. The originally planned sample size was 240 participants. Due to slower than anticipated enrollment, the primary comparison was changed to the 2 combined telmisartan groups vs the 2 combined placebo groups and the target sample size was changed to 112 participants.Main Outcomes and MeasuresThe primary outcome was the 6-month change in 6-minute walk distance (minimum clinically important difference, 8-20 m). The secondary outcomes were maximal treadmill walking distance; Walking Impairment Questionnaire scores for distance, speed, and stair climbing; and the 36-Item Short-Form Health Survey physical functioning score. The results were adjusted for study site, baseline 6-minute walk distance, randomization to exercise vs attention control, sex, and history of heart failure at baseline.ResultsOf the 114 randomized patients (mean age, 67.3 [SD, 9.9] years; 46 were women [40.4%]; and 81 were Black individuals [71.1%]), 105 (92%) completed 6-month follow-up. At 6-month follow-up, telmisartan did not significantly improve 6-minute walk distance (from a mean of 341.6 m to 343.0 m; within-group change: 1.32 m) compared with placebo (from a mean of 352.3 m to 364.8 m; within-group change: 12.5 m) and the adjusted between-group difference was −16.8 m (95% CI, −35.9 m to 2.2 m; P = .08). Compared with placebo, telmisartan did not significantly improve any of the 5 secondary outcomes. The most common serious adverse event was hospitalization for PAD (ie, lower extremity revascularization, amputation, or gangrene). Three participants (5.1%) in the telmisartan group and 2 participants (3.6%) in the placebo group were hospitalized for PAD.Conclusions and RelevanceAmong patients with PAD, telmisartan did not improve 6-minute walk distance at 6-month follow-up compared with placebo. These results do not support telmisartan for improving walking performance in patients with PAD.Trial RegistrationClinicalTrials.gov Identifier: NCT02593110
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Calvet, T., M. A. Cuevas, E. Tauler, M. Labrador, Y. Haget, and E. Estop. "Crystal data for p-bromochlorobenzene/p-dibromobenzene mixed crystals at 293 K." Journal of Applied Crystallography 19, no. 3 (June 1, 1986): 202. http://dx.doi.org/10.1107/s002188988608963x.
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The powder data for p-bromochlorobenzene/p-dibromobenzene mixed crystals [pBCB] x [pDBB]1 − x at 293 K are reported; their thermal stability at 293 K is given. Vertical diffractometer, graphite monochromator, Cu Kα, λ = 1.54056 Å. They are all isomorphous, monoclinic, P21/a with Z = 2. a = 15.176(6), b = 5.847(3), c = 4.078(2) Å, β = 112.57(3)°, V = 334.2 Å3, Dx = 1.947 Mg m−3 for [pBCB]0.90[pDBB]0.10; JCPDS No. 36-1975. a = 15.222 (7), b = 5.847 (3), c = 4.083(2) Å, β = 112.60(3)°, V = 335.5 Å3, Dx = 1.984 Mg m−3 for [pBCB]0.80[pDBB]0.20; JCPDS No. 36-1974. a = 15.260(5), b = 5.839(2), c = 4.084(2) Å, β = 112.57(1)°, V = 336.1 Å3, Dx = 2.024 Mg m−3 for [pBCB]0.70[pDBB]0.30; JCPDS No. 36-1973. a = 15.298(4), b = 5.845(3), c = 4.091(2) Å, β = 112.60(2), V = 337.7 Å3, Dx = 2.058 Mg m−3 for [pBCB]0.60[pDBB]0.40; JCPDS No. 36-1972. a = 15.340(4), b = 5.844(2), c = 4.092(2) Å, β = 112.60(2)°, V = 338.7 Å3, Dx = 2.096 Mg m−3 for [pBCB]0.50[pDBB]0.50; JCPDS No. 36-1971. a = 15.370(5), b = 5.843(2), c = 4.097(2) Å, β = 112.62(2)°, V = 339.6 Å3, Dx = 2.134 Mg m−3 for [pBCB]0.40[pDBB]0.60; JCPDS No. 36-1970. a = 15.404(6), b = 5.840(2), c = 4.100(2) Å, β = 112.67(2)°, V = 340.4 Å3, Dx = 2.172 Mg m−3 for [pBCB]0.30[pDBB]0.70; JCPDS No. 36-1969. a = 15.437(5), b = 5.842(2), c = 4.103(2) Å, β = 112.66(2)°, V = 341.4 Å3, Dx = 2.209 Mg m−3 for [pBCB]0.20[pDBB]0.80; JCPDS No. 36-1968. a = 15.468(4), b = 5.838(2), c = 4.104(2) Å, β = 112.70(2)°, V = 341.9 Å3, Dx = 2.249 Mg m−3 for [pBCB]0.10[pDBB]0.90; JCPDS No. 36-1967.
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Nadhifa, Faralia, Bakhrudin All Habsy, and Tadoer Ridjal. "KONSELING KELOMPOK REALITA UNTUK MENINGKATKAN KEDISIPLINAN BELAJAR SISWA MADRASAH IBTIDAIYAH, EFEKTIFKAH?" Perspektif Ilmu Pendidikan 34, no. 1 (April 29, 2020): 49–58. http://dx.doi.org/10.21009/pip.341.6.
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Penelitian ini bertujuan untuk mengetahui keefektifan konseling kelompok realita dalam meningkatkan kedisipilinan siswa di sebuah Madrasah Ibtidaiyah. Penelitian ini, menggunakan rancangan eksperimen dengan desain pretest dan posttest control group. Penelitian dilaksanakan selama 6 bulan dengan menggunakan pendekatan konseling kelompok realita dengan teknik metafora dan diskusi kualitas. Data dianalisis menggunakan uji t-test. Berdasarkan hasil penelitian ditemukan bahwa konseling kelompok realita efektif untuk meningkatkan kedisiplinan belajar siswa pada Madrasah Ibtidaiyah yang dijadikan sampel penelitian. Saran dan rekomendasi dari hasil penelitian ini antara lain: 1) Guru Bimbingan dan Konseling dapat menerapkan layanan konseling kelompok ralita sebagai alternatif untuk meningkatkan kedisiplinan siswa, 2) Peneliti selanjutnya dapat menggunakan teknik lain yang relevan untuk menguji keefektifan konseling kelompok realita.
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Kuz’ma, Yu B., Yu Prots, and Yu Grin. "Crystal structure of erbium vanadium tantal boride, Er(V0.77Ta0.23)VB6." Zeitschrift für Kristallographie - New Crystal Structures 218, no. 2 (June 2003): 159–60. http://dx.doi.org/10.1524/ncrs.2003.218.2.159.
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Kozak, M., M. Jaskólski, and K. H. Röhm. "Preliminary crystallographic studies of Y25F mutant of periplasmic Escherichia coli L-asparaginase." Acta Biochimica Polonica 47, no. 3 (September 30, 2000): 807–14. http://dx.doi.org/10.18388/abp.2000_3998.
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Periplasmic Escherichia coli L-asparaginase II with Y25F mutation in the active-site cavity has been obtained by recombinant techniques. The protein was crystallized in a new hexagonal form (P6(5)22). Single crystals of this polymorph, suitable for X-ray diffraction, were obtained by vapor diffusion using 2-methyl-2,4-pentanediol as precipitant (pH 4.8). The crystals are characterized by a = 81.0, c = 341.1 A and diffract to 2.45 A resolution. The asymmetric unit contains two protein molecules arranged into an AB dimer. The physiologically relevant ABA'B' homotetramer is generated by the action of the crystallographic 2-fold axis along [1, -1, 0]. Kinetic studies show that the loss of the phenolic hydroxyl group at position 25 brought about by the replacement of Y with F strongly impairs kcat without significantly affecting Km.
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Han, Ying, Liqing Chen, Wei Liu, Xin Xin, Lingwei Meng, Xiaoyang Chu, Wei Huang, Mingji Jin, and Zhonggao Gao. "An HPLC–MS/MS method for quantitation of trelagliptin and application in a comparative pharmacokinetic study." Bioanalysis 11, no. 19 (October 2019): 1755–65. http://dx.doi.org/10.4155/bio-2018-0238.
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Aim: A sensitive HPLC–MS/MS approach was established to quantify trelagliptin and explore the pharmacokinetic characteristics in rats for up to 7 days. Meanwhile, the pharmacokinetic differences of trelagliptin were investigated for the first time. Results/methodology: The ion pairs of m/z 358.2→341.2 for trelagliptin and m/z 340.3→116.1 for alogliptin (internal standard) were detected in positive mode. Trelagliptin displayed a good linearity in the range of 4–4000 ng/ml (r2 = 0.9997) with a mean recovery rate of 86.9–94.1%. Discussion/conclusion: Compared with normal groups, the T1/2, apparent volume of distribution, area under the curve and bioavailability in model rats were significantly increased while the apparent plasma clearance decreased. The approach is proved to be straightforward and appropriate for quantitation of trelagliptin and application in pharmacokinetics studies.
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Yadav, Raju, Kavita Arvindakshan, Balraj Singh, Rajesh Kumar Sharma, Vikash Kumawat, and Rupa Ujjawal. "Influence of Soil Physio-chemical Properties and Available Nutrient Status by Organic Growth Promoters under Pea (Pisum sativum L.) Cultivation." International Journal of Plant & Soil Science 35, no. 21 (October 26, 2023): 613–19. http://dx.doi.org/10.9734/ijpss/2023/v35i214018.
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A field experiment was conducted at Vegetable Farm, Department of Vegetable Science, College of Horticulture and Forestry, Jhalawar (Rajasthan) during rabi season 2021-2022 on pea. The experiment consisted thirteen treatments of organic growth promoters viz. Panchagavya @ 2 %, Panchagavya @ 4%, Panchagavya @ 6 %, Jeevamrut @ 2%, Jeevamrut @ 4%, Jeevamrut @ 6 % and Brahmastra @ 2%, Brahmastra @4%, Brahmastra @6% and vermiwash @ 5%, vermiwash @10%, vermiwash @15% and Control) and laid out in randomized block design with three replications. Results revealed that the maximum pod yield (169.93 q/ha) of pea was recorded with foliar spray of Panchagavya @ 4 % over control. However, it was found at par with foliar spray of vermiwash @ 10% and vermiwash @15% on pea. The foliar spray of growth promotors did not significantly influence soil physio-chemical properties i.e. soil pH, electrical conductivity and organic carbon after harvest of the crop. The maximum available nitrogen (341.0 kg/ha) was recorded under application of Panchagavya @ 4% and minimum available nitrogen (337.2 kg/ha) in control. Available phosphorus (kg/ha) and potassium did not significantly influence by different growth promotors in the soil after harvest of the crop.
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Salleh, Wan Mohd Nuzul Hakimi Wan, Farediah Ahmad, and Khong Heng Yen. "Evaluation of Antioxidant, Anticholinesterase and Antityrosinase Activities of Malaysian Cinnamomum Species." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (June 28, 2016): 125–32. http://dx.doi.org/10.3329/dujps.v14i2.28500.
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The extracts of the leaves and bark of five Cinnamomum species (C. altissimum, C. griffithii, C. javanicum, C. macrocarpum, and C. velutinum) were screened to evaluate their antioxidant, anticholinesterase, and antityrosinase activities. The bark of C. altissimum showed the highest phenolic content (130.1 mg GA/g), free radical scavenging by DPPH (IC50 126.2 ?g/mL) and ferric reducing antioxidant power (FRAP) assays (341.2 mg AA/g). All of the extracts inhibited linoleic acid peroxidation by greater than 70%, with the leaves of C. altissimum exhibiting the highest inhibition of 87.7%. The leaves of C. javanicum revealed the highest inhibition on anticholinesterase (AChE 30.8%) and butyrylcholinesterase (BChE 46.8%) enzymes. The leaves and bark of C. altissimum and C. velutinum exhibited greater than 20% tyrosinase inhibition, with the leaves of C. altissimum having the highest percentage of inhibition (34.6%). These bioactivities indicate that some Cinnamomum species have therapeutic potential in medicinal research and development of new drugs candidates.Dhaka Univ. J. Pharm. Sci. 14(2): 125-132, 2015 (December)
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Aryani, Lia, Bintang Surya Bhakti, Ahmad Riziq Mubarok, Ardita Septiyani, R. Henny Mulyani, Nanang Sudrajat, and Dedi Dedi. "THE EFFECT OF BAKELITE BINDERS ON MAGNETIC PROPERTIES AND HARDNESS VALUES OF MQP-TYPE BONDED NdFeB MAGNETS." Metalurgi 38, no. 2 (October 9, 2023): 49. http://dx.doi.org/10.55981/metalurgi.2023.718.
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Permanent magnets are important in modern society as components in various devices used by many industries and consumers, especially in generators and electric motors. Bonded magnet technology allows combining powdered magnetic materials with polymers as a binder to produce magnetic components that can be applied to certain applications, such as SynRM (synchronous reluctance) motors. Bonded magnets are easy to form without sacrificing their magnetic properties, which are too large, and also reduce costs, making them more effective and efficient. This paper reports the results of a study on the manufacture of bonded magnets NdFeB using bakelite binder on MQP-type NdFeB magnets with a bakelite variation of 0.5 - 2 wt.%. The characterization included testing magnetic properties with Permagraph, morphology with SEM (scanning electron microscope), and hardness values with micro Vickers hardness tester. The results of this study obtained remanence values in the range 5.53 - 6.44 kG and hardness values in the range 341.8 - 507.9 HV for NdFeB bonded magnets. According to SEM observations, the bakelite polymer matrix has successfully bound NdFeB grains, and no porosity is visible.
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Wu, Shufen, Changyan Dong, Meihui Zhang, Yi Cheng, Xiaobo Cao, Benxu Yang, Chao Li, and Xin Peng. "Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin." Foods 13, no. 10 (May 17, 2024): 1573. http://dx.doi.org/10.3390/foods13101573.
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Red yeast rice dietary supplements have been proven to ameliorate hyperglycemia, but the mechanism was unclear. In this work, ankaflavin (AK) and monascin (MS), as typical pigments derived from red yeast rice, were found to exert noteworthy inhibitory ability against α-glucosidase, with an IC50 of 126.5 ± 2.5 and 302.6 ± 2.5 μM, respectively, compared with acarbose (IC50 = 341.3 ± 13.6 μM). They also exhibited mixed-type inhibition of α-glucosidase in vitro and caused fluorescence quenching through the static-quenching process. Molecular-docking studies indicated that AK and MS bind to amino acid residues outside the catalytic center, which induces structural changes in the enzyme, thus influencing its catalytic activity. The anti-glycation ability of Monascus-fermented products was evaluated, and they exhibited a high inhibition rate of 87.1% in fluorescent advanced glycation end-product formation at a concentration of 0.2 mg mL−1, while aminoguanidine showed a rate of 75.7% at the same concentration. These results will be significant in broadening the application scope of Monascus pigments, especially AK and MS, in treating type 2 diabetes.
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Arabiat, Sahar, and Mohamed F. R. Khan. "Sensitivity of Rhizoctonia solani AG-2-2 from Sugar Beet to Fungicides." Plant Disease 100, no. 12 (December 2016): 2427–33. http://dx.doi.org/10.1094/pdis-04-16-0525-re.
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Rhizoctonia damping-off and crown and root rot caused by Rhizoctonia solani are major diseases of sugar beet (Beta vulgaris L.) worldwide, and growers in the United States rely on fungicides for disease management. Sensitivity of R. solani to fungicides was evaluated in vitro using a mycelial radial growth assay and by evaluating disease severity on R. solani AG 2-2 inoculated plants treated with fungicides in the greenhouse. The mean concentration that caused 50% mycelial growth inhibition (EC50) values for baseline isolates (collected before the fungicides were registered for sugar beet) were 49.7, 97.1, 0.3, 0.2, and 0.9 μg ml−1 and for nonbaseline isolates (collected after registration and use of fungicides) were 296.1, 341.7, 0.9, 0.2, and 0.6 μg ml−1 for azoxystrobin, trifloxystrobin, pyraclostrobin, penthiopyrad, and prothioconazole, respectively. The mean EC50 values of azoxystrobin, trifloxystrobin, and pyraclostrobin significantly increased in the nonbaseline isolates compared with baseline isolates, with a resistant factor of 6.0, 3.5, and 3.0, respectively. Frequency of isolates with EC50 values >10 μg ml−1 for azoxystrobin and trifloxystrobin increased from 25% in baseline isolates to 80% in nonbaseline isolates. Although sensitivity of nonbaseline isolates of R. solani to quinone outside inhibitors decreased, these fungicides at labeled rates were still effective at controlling the pathogen under greenhouse conditions.
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Sutrisno, Widayani, Mitra Rahayu, and Damar Rastri Adhika. "Thermal Properties of Sago Fiber-Epoxy Composite." Fibers 8, no. 1 (December 28, 2019): 4. http://dx.doi.org/10.3390/fib8010004.
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The aim of this study is to analyze the thermal properties of sago fiber-epoxy composite. The sago fiber-based composite has been prepared using epoxy resin as the matrix, via a simple mixing followed by compression. The compression process includes hot compression (100 °C/10 kgf cm−2) and cold compression (ambient/10 kgf cm−2). The composite series was prepared with 9%, 13%, 17%, 20%, and 23% (w/w) of epoxy resin. Microstructures of all materials used were observed using an SEM (scanning electron microscope) instrument. The thermal properties of the composite and its components were examined through TG/DTA characterization. The samples were heated using the heating rate of 10 °C/min from room temperature to 400 °C, except for epoxy resin, which was heated to 530 °C. TG/DTA results depict three stages of thermal processes of sago fiber-epoxy composite: evaporation of water molecules at below 100 °C with the peak point within the range of 51.3 and 57.3 °C, the damage of sago fiber within the range of 275 and 370 °C with the peak point within the range of 333.3 and 341.3 °C and the damage of epoxy resin at above 350 °C with the peak point at 376.2 °C.
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Salvador, F., and J. Wiseman. "The Influence of free fatty acid on the apparent metabolisable energy value of tallow fed to broiler chicks." Proceedings of the British Society of Animal Production (1972) 1989 (March 1989): 86. http://dx.doi.org/10.1017/s0308229600010783.
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Fats are important but variable energy-yielding ingredients in diets for broilers. One of the factors that may affect the dietary energy value of fats is the proportion of free fatty acids which, together with rate of inclusion of fat and the age of the bird, must be considered in fat evaluation. The current experiment was designed to investigate the effect of free fatty acid content of tallow on the apparent metabolisable energy values for broilers.Tallow and tallow acid oil (Table 1) were obtained for evaluation. Tallow (A) of free fatty acid content 138.4 g/kg was hydrolysed to produce a fat (E) of free fatty acid (FFA) content 952.1 g/kg. Fat A and B were blended in the proportions A75:B25, A50:B50 and A25:B75 giving fats of 341.5, 545.3 and 748.7 g/kg FFA respectively which were included at rates of 40 g/kg, 80 g/kg and 120 g/kg at the expense of the energy-yielding ingredients. The 16 experimental diets - basal (Table 2) together with 15 containing fats - were evaluated with Ross 1 broiler chicks of 1.5 weeks (5 replicates of cage of 2 birds) and 7.5 weeks of age (5 replicates of cage of 1 bird).
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Dechates, Bothamai, Thachanun Porntharukchareon, Supamas Sirisreetreerux, Phonthip Therawit, Supanat Worawitchawong, Gaidganok Sornsamdang, Kamonwan Soonklang, and Kriangkrai Tawinprai. "Immune Response to CoronaVac and Its Safety in Patients with Type 2 Diabetes Compared with Healthcare Workers." Vaccines 11, no. 3 (March 17, 2023): 684. http://dx.doi.org/10.3390/vaccines11030684.
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Background: Vaccines for SARS-CoV-2 have been critical for preventing disease. Previous research showed patients with diabetes have impaired immunity. This study aimed to determine the immunity to coronavirus after CoronaVac by comparing patients with type 2 diabetes (T2D) and healthcare workers (HCW). Materials and methods: A prospective cohort study evaluated immune responses and safety after two doses of CoronaVac in T2D and HCW groups at Chulabhorn Hospital. The levels of total antibodies against the receptor-binding domain (anti-RBD) of the SARS-CoV-2 spike protein at baseline and 4 weeks after vaccination were collected. The level of anti-RBD concentrations was reported as geometric mean concentration (GMC) and compared between groups using the geometric mean ratio (GMR). Results: 81 participants were included; 27 had T2D and 54 were HCW. After complete vaccination, anti-RBD concentrations were not significantly different between T2D (57.68 binding antibody units (BAU)/mL, 95% confidence interval (CI) = 29.08; 114.44) and HCW (72.49 BAU/mL, 95% CI = 55.77; 94.22) groups. Subgroup analysis showed the GMC of anti-RBD was significantly lower in T2D patients with dyslipidaemia (50.04 BAU/mL) than in T2D patients without dyslipidaemia (341.64 BAU/mL). Conclusions: The immune response at 4 weeks after two doses of CoronaVac did not significantly differ between patients with T2D and HCW.
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Dedy Pratama, Hendro Sudjono Yuwono, Rudi Supriyadi, Herry Herman, Fachreza Aryo Damara, and Avicenna Akbar. "Antioxidant Properties of Curcumin and Its Impact on Arteriovenous Fistula Maturation in End-Stage Kidney Disease Patient with Diabetes Mellitus Type 2." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (December 25, 2020): 7624–29. http://dx.doi.org/10.26452/ijrps.v11i4.4107.
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The risk of maturation failure in arteriovenous fistula (AVF) remains high. Curcumin poses antioxidant effects may enhance AVF maturation. This study evaluates the antioxidant effect of Curcumin on AVF maturation among type 2 diabetic patients (T2DM) with end-stage renal disease (ESRD). This was a single-blinded, randomized controlled trial conducted in three tertiary hospitals in Jakarta, Indonesia. Patients underwent the first hemodialysis. A total of 67 patients divided into groups of Curcumin, acetylsalicylic acid, and placebo. After 4 weeks, TAC level among the curcumin group was significantly higher compared to acetylsalicylic acid, and placebo groups 794.2(457.4±1473.7) µM vs. 519.2(247.7 ± 1027.7) µM and 794.2(457.4± 1473.7) µM vs. 542.5(281.91± 1054.64) µM, respectively (p<0.05). Also, TAC after 8 weeks was significantly higher among curcumin group compared to acetylsalicylic acid, and placebo groups (820.5(380.7± 1643.7) µM vs. 509.7(341.0± 981.91) µM and 820.5(380.7± 1643.7) µM vs. 497.7(324.7± 979.2) µM, respectively (p<0.001). The TAC level patients with mature AVF were also higher. A 2000 mg/day of curcumin increases antioxidant capacity after 4 and 8 weeks following AVF surgery among ESRD with T2DM.
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Guo, Hui. "Effects of Stoichiometric Ratio on the Microstructure and Electrochemical Properties of Ml0.96Mg0.04(Ni0.846Co0.014Mn0.08Al0.06)x (x=5.0-5.3) Alloys." Advanced Materials Research 1053 (October 2014): 87–92. http://dx.doi.org/10.4028/www.scientific.net/amr.1053.87.
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The as-cast Ml0.96Mg0.04(Ni0.846Co0.014Mn0.08Al0.06)x (x=5.0, 5.1, 5.2, 5.3) hydrogen storage alloys were prepared by vacuum induction melting method under argon atmosphere. Crystal structure, hydrogen absorption, desorption properties and electrochemical properties were investigated by means of XRD, SEM, EDS, PCT (Pressure Composition isotherms) and tri-electrode tests. The XRD and SEM results showed that the alloy were consisted of CaCu5-type phase as the main phase and (Al, Mn)(Ni, Co)2-type phase as the secondary phase. The content of the second phase increased as the stoichiometric ratio increased. PCT results indicated that the amount of hydrogen absorption decreased, while the hydrogen-desorption plateau pressure increased as the stoichiometric ratio increased. The electrochemical test results exhibited that the alloys had excellent activation performance at the second cycle, and the maximum capacity of the alloys were 341.2 mAh/g, 336.5 mAh/g, 333.6 mAh/g, 330.3 mAh/g as the stoichiometric x=5.0, 5.1, 5.2, 5.3, respectively. In addition, the cycle life increased slightly as the stoichiometric ratio increased. ML0.96Mg0.04(Ni0.846Co0.014Mn0.08Al0.06)5.0 had the best performance due to the combine action of trace Mg and stoichiometric ratio.
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Dewi, M. C., R. Anggara, R. Hidayatullah, and I. Nurhakim. "The planning of mine drainage system at PT Perkasa Inakakerta, East Kutai Regency." IOP Conference Series: Earth and Environmental Science 882, no. 1 (November 1, 2021): 012056. http://dx.doi.org/10.1088/1755-1315/882/1/012056.
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Abstract This research located in Beruang Block Kalimantan. The purpose of the mine drainage planning system is to control runoff water. Therefore, an excellent drainage system is needed without interfering with mining activities such as runoff water pollution, which could cause contamination in the surrounding area and outside the mining sites. Based on the analysis of rainfall data of 2009-2020, the precipitation plan was 341.67 mm/day; the concentration time was 2.37 h, the rain intensity was 41.06 mm/h, and repeated rain periods were 2-years. The extensive catchment area was 1.52 km2 because the runoff entering the sump was 44.38 m3/h. To prevent the water from entering the mining area, an open channel was made around the mine openings, and the water flows naturally into the sump. The water pumped into the settling pond with the pump type Allight HL 150MHD-IT at 50 m/s for 3-days with a single rain, resulting in total water volume of 17,556.5 m3/day. A trapezoidal shape was designed for a sump with dimensions of 3.96 m in length and width at the surface, 1.79 m length and width at the base, and 1.03 depth.
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Silvère, Dimi Ngatse, MISSOKO MABEKI Richard, and Akouango Parisse. "Selection of Nelores Males by Biometry and Testicular Morphology at Kila Ranch Republic of Congo." Scholars Academic Journal of Biosciences 10, no. 3 (March 30, 2022): 62–67. http://dx.doi.org/10.36347/sajb.2022.v10i03.006.
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The objective of This sud wasp to évaluâtes the corrélation tween Age, Wight and scrotal circonférence for the propose of sélection Young bredin stock. Scrotal circonférence miaulements ère performe on 152 males frangin in Age frome 23 to 25 monts, witz Wight frangin frome 341.4 to 363.5 kg. For the sud of scrotal morphologie, the animaux ère classifie intox thrène groups accordant to the following criteria: G1 - animaux without scrotal bipartition, G2- animaux witz bipartition up to 10 mm, G3 - animaux witz bipartition greater than 10 mm and for the sud of testicular morphologie, the animaux ère also classifie intox thrène groups: semi-elongated testes (SA) and globular testes (G), elongated (A). The observed correlations of scrotal circonférence witz Age and Wight and tween Wight and Age of the animal ère high and positive, respectively 0.73, 0.71 and 0.57. The results of 152 observations of scrotal morphologie showed that 142 animaux (94.08%) ère classifie as G1, 7 (4.61%) as G2 and 2 (1.32%) as G3. The distribution of testicular morphologie (n = 152) showed a high concentration in the semi-elongated group 128 animaux, i.e. (84.21%), followed by the elongated group 14 (9.21%) and globular 10 (6.58%).
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Matthew, Jacqueline, Emily Skelton, Lisa Story, Alice Davidson, Caroline L. Knight, Chandni Gupta, Dharmintra Pasupathy, and Mary Rutherford. "MRI-Derived Fetal Weight Estimation in the Midpregnancy Fetus: A Method Comparison Study." Fetal Diagnosis and Therapy 48, no. 10 (2021): 708–19. http://dx.doi.org/10.1159/000519115.
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Objectives: The aim of this study was to compare the standard ultrasound (US) estimated fetal weight (EFW) and MRI volume-derived methods for the midtrimester fetus. Methods: Twenty-five paired US and MRI scans had the EFW calculated (gestational age [GA] range = 20–26 weeks). The intra- and interobserver variability of each method was assessed (2 operators/modality). A small sub-analysis was performed on 5 fetuses who were delivered preterm (mean GA 29 +3 weeks) and compared to the actual birthweight. Results: Two MRI volumetry EFW formulae under-measured compared to US by −10.9% and −14.5% in the midpregnancy fetus (p < 0.001) but had excellent intra- and interobserver agreement (intraclass correlation coefficient = 0.998 and 0.993). In the preterm fetus, the mean relative difference (MRD) between the MRI volume-derived EFW (MRI-EFW) and actual expected birthweight (at the scan GA) was −13.7% (−159.0 g, 95% CI: −341.7 to 23.7 g) and −17.1% (−204.6 g, 95% CI: −380.4 to −28.8 g), for the 2 MRI formulae. The MRD was smaller for US at 5.3% (69.8 g, 95% CI: −34.3 to 173.9). Conclusions: MRI-EFW results should be interpreted with caution in midpregnancy. Despite excellent observer agreement with MRI volumetry, refinement of the EFW formula is needed in the second trimester, for the small and for the GA and preterm fetus to compensate for lower fetal densities.
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Lu, Amy Q., and Bozho Todorich. "Combination Antivascular Endothelial Growth Factor and Modified Panretinal Photocoagulation in Management of Proliferative Diabetic Retinopathy." Journal of VitreoRetinal Diseases 4, no. 5 (July 3, 2020): 401–10. http://dx.doi.org/10.1177/2474126420930501.
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Purpose: This work evaluates the effects of combined intravitreal antivascular endothelial growth factor (anti-VEGF) and modified panretinal photocoagulation (PRP) for management of proliferative diabetic retinopathy (PDR). Methods: This retrospective case series included 37 eyes of 33 patients with high-risk PDR. Anti-VEGF injections (≥ 2) were followed by modified, midperipheral PRP performed in 2 or more sessions. Visual and anatomic outcomes were tracked for 1 year after treatment. Regression analysis was performed for factors predictive of final outcomes. Results: Mean visual acuity (VA) at initial and final visit were 20/50 and 20/40 ( P = .22), respectively, over a mean follow-up duration of 341.4 days. Central foveal thickness decreased from 321.8 µm to 258.6 µm ( P = .01). Resolution of PDR was achieved in 94.6% of eyes, with 5.4% of eyes requiring additional anti-VEGF for persistent neovascularization. Final VA was significantly associated with baseline VA, VA at 1 month, and any adverse anatomical events. Treatment noncompliance was present in 24.3%; compliance decreased with increasing medical comorbidities, but was not significantly associated with final VA. Conclusions: Combination of anti-VEGF and modified PRP preserved VA and yielded PDR regression in the majority of eyes. This combination provides rapid PDR regression with anti-VEGF while achieving durable disease suppression in this real-world cohort without traditional PRP.
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Bakara, Derison Marsinova, and Kurniyati. "Self-Management Education to Control Blood Sugar Levels and Hba1c Value for Type 2 Diabetes Patients." Malaysian Journal of Nursing 14, no. 01 (2022): 84–89. http://dx.doi.org/10.31674/mjn.2022.v14i01.012.
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Backgroud: Self-care education can be carried out patients with diabetes through the Diabetes Self-Management Education (DSME) method. The DSME method helps people to perform with type 2 diabetes self-management in managing and treating type 2 diabetes, such as controlling blood sugar levels and HbA1c values. Objective: The purpose of this research is to understand the effect of DSME for reducing blood sugar levels and decreasing HbA1c values in type 2 diabetes patients. Methods: The design of this research is a Pre-Experimental with Pretest-Posttest Group Design with a Pretest-Posttest Group Design, approach which aims to see the use of the DSME method for reducing blood sugar levels and decreasing HbA1c values in type 2 diabetes patients. This research was conducted from July to October 2021. The research location was at the Curup Regional General Hospital, Rejang Lebong Regency. Respondents in this study were 35 patients with type 2 diabetes. The instrument used was the DSME method consisting of 3 instruments, including the theoretical concept of diabetes, care and treatment of diabetes, and complications of diabetes. Results: The results of the study show a significant change in blood sugar levels before and after the DSME. Before being carried out, blood sugar levels were with a Mean±SD of 341.60±157.589; meanwhile, after the intervention, blood sugar levels became 107.97±9.984 with a p:0.001. On the other hand, the HbA1c Value before intervention was Mean±SD 8.4313±2.2610, and after the intervention, the HbA1c value became 6.4553±1.2426 with p=0.001. Conclusion: DSME can be used as an alternative intervention that decreases in blood sugar levels and HbA1c values in patients with type 2 diabetes.
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Arzu ÇIĞ. "Tolerance of Daffodil (Narcissus poeticus L. c.v. “Ice Folies”) to Nickel Contaminated Media." ISPEC Journal of Agricultural Sciences 4, no. 1 (May 2, 2020): 105–12. http://dx.doi.org/10.46291/ispecjasvol4iss1pp105-112.
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The objective of this study was to determine the tolerance of daffodil (Narcissus poeticus L. c.v. “Ice Folies”) as a hyperaccumulator plant to nickel contaminated media. This research was carried out in a completely randomized plot experimental design with three replications in green house conditions. Four doses of nickel (control, 25 mg kg-1, 50 mg kg-1, 75 mg kg-1) were applied to each growing media having 500 g soil:sand mixture in 2:1 ratio. The distillate water was used in irrigation and Hoagland solution was applied for fertilization. At the end of the experiment, effects of nickel applications on leaf length, plant length, flower length (P<0.01) and flower diameter, stem diameter (P<0.05) were found significant, except leaf number and leaf length. The lowest first flowering time, full flowering time and first floret withering time were obtained in control and 75 mg kg-1 nickel application. The highest leaf length (341.60 mm), plant length (418.24 mm), flower length (70.74 mm) and stem diameter (7.63 mm) were obtained in 75 mg kg-1 nickel application. The highest flower diameter was found as 78.35 mm in 25 mg kg-1 nickel application. Generally, while the nickel doses increased flowering time, leaf length, plant length, flower length and flower diameter increased.
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Fan, Xianyuan, Hong Liu, Weikun Song, and Chia-Yuan Chang. "Enhanced Photodegradation of p-Nitrobenzoic Acid by Binary Mixtures with Ba2+/TiO2 and MCM-41." Materials 14, no. 9 (May 5, 2021): 2404. http://dx.doi.org/10.3390/ma14092404.
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A novel Ba(II)/TiO2–MCM-41 composite was synthesized using binary mixtures with Ba2+/TiO2 and MCM-41, and Ba2+ as a doping ion of TiO2. The specific surface area and pore structure characterizations confirm that a mesoporous structure with a surface area of 341.2 m2/g and a narrow pore size distribution ranging from 2 to 4 nm was achieved using Ba(II)/TiO2–MCM-41. Ba(II)/TiO2 particles were synthesized into 10–15 nm particles and were well dispersed onto MCM-41. The diffraction peaks in the XRD patterns of TiO2–MCM-41 and Ba(II)/TiO2–MCM-41 were all attributed to anatase TiO2. By taking advantage of MCM-41 and Ba2+, the photocatalytic performance of Ba(II)/TiO2–MCM-41 was remarkably enhanced by suppressing its rutile phase, by lowering the band gap energy, and by facilitating the dispersion of TiO2. Therefore, the photodegradation efficiencies of p-nitrobenzoic acid (4 × 10−4 mol/L) by various photocatalysts (60 min) under UV light irradiation are arranged in the following order: Ba(II)/TiO2–MCM-41 (91.7%) > P25 (86.3%) > TiO2–MCM-41 (80.6%) > Ba(II)/TiO2 (55.7%) > TiO2 (53.9%). The Ba(II)/TiO2–MCM-41 composite was reused for five cycles and maintained a high catalytic activity (73%).
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Klein, John Lenon, Sander Martinho Adams, Dari Celestino Alves Filho, Ivan Luiz Brondani, Luiz Ângelo Damian Pizutti, Rodrigo Soares Volpatto, Pedro Henrique Tonetto de Bem, Jeriel Dias, Rafaela da Silva Oliveira, and Giana Garcia Ballin. "Beef heifer weight loss during gestation and its effects on progeny performance." Research, Society and Development 11, no. 11 (August 31, 2022): e501111133862. http://dx.doi.org/10.33448/rsd-v11i11.33862.
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The objective of the present study was to evaluate the intensity of weight loss in beef heifers during gestation and its effects on progeny performance up to 205 days of age. Sixty pregnant heifers aged 3 or 4 years, born between 2015 and 2017, from the rotational cross between Charolais and Nellore breeds were used. Females were divided according to the intensity of weight loss in the gestation period (7, 14, and 21%) and age at first calving (3 and 4 years), in a completely randomized design in a 3 x 2 factorial scheme. Lost up to 21% (T21) of body weight during gestation and had higher body conditions at the end of the breeding season (3.12 vs 3.02 and 3.04 points) and lower body weight at calving (341.96 vs 386.26 and 362.95 kg) about T7 and T14 heifers. The birth weight of the calves showed a tendency to increase as the weight loss of the pregnant heifers increased, with values of 29.46, 30.60 and 32.76 kg for treatments T7, T14 and T21, without reflections on the post-weaning performance of the progeny. In general, the loss of 14 or 21% of the heifer's body weight during pregnancy reduces the weight at the first calving, while heifers calved at 4 years of age are heavier and give rise to progeny with greater productive potential up to 205 days of age.
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Goo, Susan J., Eleni Frangos, Emily A. Richards, Marta Ceko, Brenda L. Justement, Patrick Korb, Brian T. Walitt, Luana Colloca, and M. Catherine Bushnell. "Attitudes and Perceptions Toward Authorized Deception: A Pilot Comparison of Healthy Controls and Fibromyalgia Patients." Pain Medicine 21, no. 4 (April 22, 2019): 794–802. http://dx.doi.org/10.1093/pm/pnz081.
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Abstract Objective Little is known about the perceptions and attitudes of participants who volunteer in studies involving authorized deception. Thus, this cross-sectional pilot study measured, for the first time, the perceptions about participation in an authorized-deception placebo analgesia study in chronic pain patients with fibromyalgia and assessed whether their perceptions differed from healthy controls. Methods An anonymous survey with questions about trust in research and willingness to participate in future research involving deception was mailed to participants in both groups after completion of the parent study. Statistical analyses were performed using the Mann-Whitney U and chi-square tests (31 controls and 16 fibromyalgia patients were included in the analyses). Results The majority of participants expressed little or no concern about the deception, still trusted the scientific process, and found the debriefing procedure helpful and worthwhile. Group differences were found in willingness to 1) participate in the parent study had the deceptive element been disclosed in advance (controls = definitely, fibromyalgia patients = probably, U = 341.5, P = 0.01) and 2) participate in future studies (controls = definitely, fibromyalgia patients = probably, U = 373, P < 0.001). Conclusions Despite slightly less favorable responses of fibromyalgia patients and the relatively small size of the study, these findings suggest that attitudes and perceptions about participating in an authorized placebo study remain positive in both healthy and chronic pain populations.
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Kovalev, Sergei Grigor’evich, and Sergei Sergeevich Kovalev. "P-T parameters of metamorphism of the rocks of the differentiated body of the Misaelga complex (western slope of the Southern Urals)." Geologicheskii vestnik, no. 1 (March 13, 2023): 35–54. http://dx.doi.org/10.31084/2619-0087/2023-1-4.
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The article presents materials on the P-T parameters of metamorphism of the rocks of the differentiated body of the Misaelga complex. Based on the study of metamorphogenic minerals and mineral associations: amphibole, amphibole-plagioclase, amphibole-garnet, epidote-garnet, muscovite, chlorite, ilmenite-titanomagnetite, a gradual decrease in temperature and pressure was established from the final stages of the magmatic stage of formation of rocks of the Misaelga complex to the beginning of the metamorphogenic stage.
It is shown that the process of amphibolization begins immediately when the temperature of the residual melt drops by ~100°С (from 800°С to 700°С), which indicates the autometamorphic character of rock alteration. At the same time, the decomposition of the solid solution in titanomagnetite and ilmenite begins (766–588°С). Further changes include alteration (albitization) of plagioclase (550–>400°С), sericitization (~ 300°С) and chloritization (333–157°С).
The association of minerals with garnet, distributed in a narrow interval of the section at a depth of 341.5 m with a horizon thickness of no more than 2–2.5 m, is a zone in which dynamothermal metamorphism manifested itself, due to fluid working out of the substrate of the Taratash complex in shear deformation zones, identified in the interval 1400–1200 Ma. The P-T parameters of dynamothermal metamorphism, determined by the garnet-epidote association, correspond to 550–580°С at a pressure of 2 kbar, and according to the garnet-amphibole geobarometer – 300–400°С. At the same time, it should be emphasized that these associations characterize the regressive stage of metamorphism.
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Yasir, Al-Saidan Khudhair Joudah. "Effect of Magnetization of Nano Fertilization on The Growth and Yield of Wheat Triticum Aestivum L." IOP Conference Series: Earth and Environmental Science 923, no. 1 (November 1, 2021): 012087. http://dx.doi.org/10.1088/1755-1315/923/1/012087.
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Abstract A field experiment was conducted in Al-Fadhiliya city, Dhi Qar province during the winter agricultural season 2019 - 2020 for the purpose of studying the effect of magnetization of nano Fertilization on the growth and yield of wheat. The experiment was carried out according to Split Plot Design and using the RCBD Design with three replications. The first factor included Magnetization levels of the Nano Fertilization (Gs) (0 Gs (Gs1),750 Gs (Gs2),1500 Gs (Gs3) for 15 minute (in main plot) while the second factor included the Nano Fertilization levels for (N, P) (F) 1 Kg.ha−1(F1), 1.5 Kg.ha−1(F2), 2 Kg.ha−1(F3)(according to the recommendation of the manufacturer (1 - 2 Kg.ha−1))(in sub plot). Mineral fertilizer add for (N, P) by 120 Kg N.ha−1, 100 Kg P ha−1. Mineral and nano fertilizer section for three growth stages (ZGs21, ZGs32, ZGs49). The results showed a positive response to the studied traits of variety Bohouth 22 (Plant height, number of tillers, number of grains and total grain yield) given the highest averages at the level of magnetism (Gs3) and fertilization level (F3)(109.33 cm, 426.2 tiller.m−2, 73.22 grain. spike−1, 1.859 t.d−1),(108.44 cm, 471.4 tiller.m−2, 77.78 grain. spike−1, 1.915 t.d-1) respectively, while the level of magnetism (Gs1) and fertilization level (F1) giving the lowest averages (95.11 cm, 341.3 tiller.m−2, 60.11 grain. spike−1, 1.437 t.d−1), (96.22 cm, 312.1 tiller.m−2, 54.00 grain. spike−1, 1.412 t.d−1) respectively. The level of magnetism (Gs1) and fertilization level (F1) gave the highest average in weight 1000 grain (43.188, 44.266)g respectively, while the magnetization level (Gs3) and fertilization level (F3) giving the lowest average (42.092,41.182)g respectively. Interaction treatment (Gs3F3) gave the highest average grain yield 2.1773 t.d−1 while the interaction treatment (Gs1F1) gave the lowest average attained 1.218 t.d−1.
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Lukas, Robert G. "Discussion of “ Unified Approach to Ground Improvement by Heavy Tamping ” by Kwang Wei Lo, Peng Lee Ooi, and Seng Lip Lee (March, 1990, Vol. 116, No. 4)." Journal of Geotechnical Engineering 118, no. 2 (February 1992): 341–42. http://dx.doi.org/10.1061/(asce)0733-9410(1992)118:2(341.2).
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Wang, Qiuxuan, Carlos Duarte, Li Song, George Christakos, Susana Agusti, and Jiaping Wu. "Effects of Ecological Restoration Using Non-Native Mangrove Kandelia obovata to Replace Invasive Spartina alterniflora on Intertidal Macrobenthos Community in Maoyan Island (Zhejiang, China)." Journal of Marine Science and Engineering 9, no. 8 (July 22, 2021): 788. http://dx.doi.org/10.3390/jmse9080788.
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Spartina alterniflora has extensively invaded the coastline of China, including in Maoyan Island of Zhejiang Province. Ecological restoration has been conducted using non-native mangrove Kandelia obovata to replace S. alterniflora in an attempt to restore the impacted intertidal zones. To illustrate the ecological effectiveness of the restoration projects, macrobenthos communities were studied among different habitats within the restored areas, including one non-restored S. alterniflora marsh (SA) and three differently-aged restored K. obovata stands planted in 2003, 2009, and 2011 respectively (KF14, KF8, and KF6). Besides, one unvegetated mudflat (MF) adjacent to the non-restored S. alterniflora marsh and one K. obovata forest transplanted in 2006 (RKF) at a previously barren mudflat without invasion history of S. alterniflora were set as reference sites. A total of 69 species of macrobenthos were collected from Maoyan Island, and the species richness was dominated by gastropoda (23 species), polychaeta (18 species), and malacostraca (16 species). There was no significant difference between the six sites in terms of the abundance of macrobenthos, with the average values of abundance peaking in KF6 (734.7 ind m−2) and being lowest in RKF (341.3 ind m−2). The six sites had significant differences in terms of the biomass of macrobenthos. The KF8 site contained the highest average biomass (168.3 g m−2), whereas the MF site had the lowest (54.3 g m−2). The Shannon-Wiener diversity index and Pielou’s evenness index of the macrobenthos did not exhibit significant differences among the six sites. However, the results of permutational multivariate analysis of variance (PERMANOVA) revealed significant spatial differences in the macrobenthos community structure between the sites. Since KF14 shared a similar macrobenthos community structure with RKF, while representing a strikingly different structure from SA, we infer that ecological restoration using K. obovata can restore the macrobenthos community to resemble to a normally planted K. obovata forest about 15 years after restoration.
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Rajagopalan, Prasanna, and Harish C. Chandramoorthy. "(2E)-2-Benzylidene-4,7-dimethyl-2,3-dihydro-1H-inden-1-one (MLT-401), a novel arylidene indanone derivative, scavenges free radicals and exhibits antiproliferative activity of Jurkat cells." Asian Biomedicine 13, no. 4 (March 31, 2020): 131–39. http://dx.doi.org/10.1515/abm-2019-0052.
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AbstractBackgroundThe arylidene indanone scaffold has contributed many lead molecules in chemotherapeutic anticancer agent research.ObjectivesTo determine the oxidant-scavenging activities and antiproliferative activity of (2E)-2-benzylidene-4,7-dimethyl-2,3-dihydro-1H-inden-1-one (MLT-401), an arylidene indanone derivative.MethodsJurkat cells, primary lymphocytes, and Vero cells were treated with MLT-401. Antioxidant properties of MLT-401 were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH)-based, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS)-based, and ferric-reducing antioxidant potential (FRAP) assays. Inhibition of cell proliferation was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-based assay. Nuclear status was determined using a DNA fragmentation assay, and cell cycle stage was analyzed by flow cytometry. Mitochondrial membrane enzyme activities were measured using colorimetric methods.ResultsThe antioxidant assays gave MLT-401 half maximal inhibitory concentration (IC50) values of 1611 nM (DPPH-based assay), 2115 nM (ABTS-based assay), and 1586 nM (FRAP assay). MLT-401 inhibited proliferation of Jurkat cells with a concentration for 50% of maximal inhibition of cell proliferation (GI50) of 341.5 nM, being 12- and 9-fold less than GI50 concentrations for normal lymphocytes and Vero cells, respectively. MLT-401 caused nuclear fragmentation and DNA laddering as seen by electrophoresis. Jurkat cells showed a time-dependent accumulation of sub G0/G1 cells after MLT-401 treatment. Mitochondrial membrane-bound Na+/K+ ATPase, Ca2+ ATPase, and Mg2+ ATPase activities were inhibited by MLT-401 in a dose-dependent manner.ConclusionMLT-401 possesses significant antiproliferative activity and scavenges free radicals released through mitochondrial membrane damage in a Jurkat cell line model of cancer cells. Further investigation of MLT-401 as a chemotherapeutic anticancer agent and development of other arylidene indanone analogues are warranted. A detailed elucidation of mechanistic pathways is required for further development.
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Tunjung-Sari, Ariza Budi, Teguh Wahyudi, Diana Chusna Mufida, Mekania Tamarizki, Desyana Perwitahati, Ihda Kartika Syamsuddin, and Misnawi Jati. "Use of cocoa ethanolic extract for treatment of Staphylococcal infection in rabbit-skin model." Pelita Perkebunan (a Coffee and Cocoa Research Journal) 32, no. 1 (April 30, 2016): 34–42. http://dx.doi.org/10.22302/iccri.jur.pelitaperkebunan.v32i1.214.
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In septic condition, the skin normal flora Staphylococcal spp. may trigger local and sistemic skin infection. In this study antibacterial activity of cocoa ethanolic extract (CEE) against Staphylococcus aureus and Staphylococcus epidermidis infections was observed in vitro and in vivo. Ethanolic extract from unfermented cocoa beans was prepared as solution in the in vitro testing, while for in vivo testing the extract was prepared as cream. Agar well diffusion assay showed that CEE ranging from 7.8 mg/mL to 1000 mg/mL demonstrated inhibitory activity against growth of either S. aureus and S. epidermidis. Inhibitory activity of CEE was in concentration dependent manner, and was less potential than either cephalexin 4 x 10 -3 mg/mL or cefotaxime 8 x 10 -3 mg/mL. Linear regression of CEE concentration plotted against inhibition zone values ha dpredicted the minimum inhibitory concentrations (MIC) of CEE towards S. aureus and S. epidermidis were at 341.9 mg/mL and 359.7 mg/mL, respectively. Topical application of cream containing CEE at several concentrations (2%, 4%, and 8%) demonstrated healing properties towards incision wound infected with S. aureus and S. epidermidis cultures in rabbit-skin model. CEE cream promoted wound contraction and higher recovery rate than of base cream (negative control) but lower than mupirocin 2% cream. In S. aureus and S. epidermidis infected wound models, CEE cream 8% improved wound recovery to 72.7% and 86.1% from original rates of 23.5% and 34.7% (base cream application). Catechin and procyanidis are suggested playing roles in alleviation of wound inflammation and stimulation of extracellular matrix accumulation, thus accelerate the wound healing process. This study proposes utilization of cocoa bean as source of active ingredient for skin care products.
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Kilba, M.-C. F., S. Salie, and B. Morrow. "Risk factors and outcomes of extubation failure in a South African tertiary paediatric intensive care unit." Southern African Journal of Critical Care 38, no. 1 (May 6, 2022): 26–32. http://dx.doi.org/10.7196/sajcc.2022.v38i1.513.
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Background. Extubation failure contributes to poor outcome of mechanically ventilated children, yet the prevalence and risk factors have been poorly studied in South African (SA) children. Objective. To determine the prevalence, risk factors and outcomes of extubation failure in an SA paediatric intensive care unit (PICU). Methods. This was a prospective, observational study of all mechanically ventilated children admitted to a tertiary PICU in Cape Town, SA. Extubation failure was defined as requiring re-intubation within 48 hours of planned extubation. Results. There were 219 episodes of mechanical ventilation in 204 children (median (interquartile range (IQR)) age 8 (1.6 - 44.4) months). Twenty-one of 184 (11.4%) planned extubations (95% confidence interval (CI) 7.2% - 16.9%) failed. Emergency cardiac admissions (adjusted odds ratio (aOR) 7.58 (95% CI 1.90 - 30.29), dysmorphology (aOR 4.90; 95% CI 1.49 - 16.14), prematurity (aOR 4.39; 95% CI 1.24 - 15.57), and ventilation≥48 hours (aOR 6.42 (95% CI 1.57 - 26.22) were associated with extubation failure. Children who failed extubation had longer durations of ventilation (231 hours (146.0 - 341.0) v. 53 hours (21.7 - 123.0);p<0.0001); longer duration of PICU (15 (9 - 20) days v. 5 (2 - 9) days;p<0.0001) and hospital length of stay (32 (21 - 53) days v. 15 (8 - 27) days;p=0.009); and higher 30-day mortality (28.6% v. 6.7%;p=0.001) than successfully extubated children. Conclusions. Extubation failure was associated with significant morbidity and mortality in our setting. Risk factors for extubation failure identified in our context were similar to those reported in other settings.
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Strickland, Ben A., Kristine Ravina, Alexandra Kammen, Stephanie Chang, Martin Rutkowski, Daniel A. Donoho, Mike Minneti, Anna Jackanich, Joshua Bakhsheshian, and Gabriel Zada. "The Use of a Novel Perfusion-Based Human Cadaveric Model for Simulation of Dural Venous Sinus Injury and Repair." Operative Neurosurgery 19, no. 3 (January 21, 2020): E269—E274. http://dx.doi.org/10.1093/ons/opz424.
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Abstract BACKGROUND Dural sinus injuries are potentially serious complications associated with acute blood loss. It is imperative that neurosurgery trainees are able to recognize and manage this challenging scenario. OBJECTIVE To assess the feasibility of a novel perfusion-based cadaveric simulation model to provide the fundamentals of dural sinus repair to neurosurgical trainees. METHODS A total of 10 perfusion-based human cadaveric models underwent superior sagittal sinus (SSS) laceration. Neurosurgery residents were instructed to achieve hemostasis by any method in the first trial and then repeated the trial after watching the instructional dural flap technique video. Trials were timed until hemostasis and control of the region of injury was achieved. Pre- and post-trial questionnaires were administered to assess trainee confidence levels. RESULTS The high-flow extravasation of the perfusion-based cadaveric model mimicked similar conditions and challenges encountered during acute SSS injury. Mean ± standard deviation time to hemostasis was 341.3 ± 65 s in the first trial and 196.9 ± 41.8 s in the second trial (P < .0001). Mean trainee improvement time was 144.4 s (42.3%). Of the least-experienced trainees with longest repair times in the initial trial, a mean improvement time of 188.3 s (44.8%) was recorded. All participants reported increased confidence on post-trial questionnaires following the simulation (median pretrial confidence of 2 vs post-trial confidence of 4, P = .002). CONCLUSION A perfusion-based human cadaveric model accurately simulates acute dural venous sinus injury, affording neurosurgical trainees the opportunity to hone management skills in a simulated and realistic environment.
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Kim, Jung Lyun, Joyce Stechmiller, Michael Weaver, Debra Lyon, Timothy Garrett, and Debra Kelly. "TRYPTOPHAN: A POTENTIAL BIOMARKER DISTINGUISHING CHRONIC VENOUS LEG ULCERS HEALING IN OLDER ADULTS." Innovation in Aging 7, Supplement_1 (December 1, 2023): 1144–45. http://dx.doi.org/10.1093/geroni/igad104.3674.
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Abstract Chronic venous leg ulcers (CVLUs) affect 2 million persons annually, including 4% of people over age 65 years. Chronic wound healing is a complex process that is still not well understood. Indoleamine 2,3-dioxygenase (IDO) activity is highly active in chronic wounds. The study aims to examine the tryptophan (TRP) L-Kynurenine (KYN) metabolic pathway as a biomarker of CVLUs healing. We collected 60 serum samples from 30 older adult patients with CVLUs receiving weekly sharp debridement at a university wound clinic. Serum samples were collected at baseline, week 4, and week 8 until wound closure. Liquid chromatography-mass spectrometry (LC-MS) metabolomics was utilized to examine targeted metabolites. A robust Bayesian approach was employed to examine correlations between change of metabolites and linear healing slope. The mean age was 71.13 (±9.46); 25 (83.3%) were white; the mean wound area was 2823.54 (±6002.93) mm2; the mean wound duration was 341.67 (±538.29) days. A total of 11 participants had healed wounds during the study period. Those with healing CVLUs had higher levels of mean TRP at baseline and over time compared to individuals with non-healing CVLUs. Change in Kynurenic Acid (r:-0.36, Bayes factor: 3.70, 95% Credibility Interval [-0.62, -0.06]) was associated with a linear healing slope. Serum tryptophan may serve as a candidate biomarker for predicting wound healing trajectories, which can guide clinicians in making treatment decisions. Specifically, decreasing metabolites associated with the downstream activity of the kynurenine pathway, a pathway for tryptophan metabolism may be an indicator of healing under sharp debridement in CVLUs.
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Sarcev, Ivan, Branislava Petronijevic, Dubravka Markovic, and Srecko Selakovic. "Mechanical resistance of restored teeth with extensive crown damage." Serbian Dental Journal 56, no. 2 (2009): 72–77. http://dx.doi.org/10.2298/sgs0902072s.
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Introduction. Extensively damaged teeth can be restored by different core build-up materials. The aim of this study was to examine the mechanical properties of the restored maxillary premolars with composite resin, dental amalgam and glass ionomer cement (GIC) using compressive strength test. Materials and methods. Forty extracted intact human maxillary premolars were used in this study. Artificial defect in dentin was prepared using diamond bur up to the half of the anatomic crown of the tooth. After core build-up procedure, each tooth specimen was mounted in auto polymerizing acrylic resin blocks 2 mm below cement enamel junction and they were kept in distilled water at 37?C one day before testing. Then, they were placed in specially adapted devices at the angle of 183? to the longitudinal axis and subjected to a controlled load of 1 mm per minute. Results. Results showed that the best mechanical properties had samples restored with resin composite (492.5 N), then with amalgam (341.2 N) and glass ionomer cement (171.8 N). Comparing the fracture force using ANOVA, there was statistic significance between these groups (p<0.01). There were significant differences among control group and restored teeth with composite resin, amalgam and GIC. There was no significant difference in values of fracture forces between groups with composite resin and amalgam. The fracture force corresponding to the teeth restored with the GICs was significantly lower compared to the control group and the group with composite resin and amalgam. Conclusion. Satisfactory mechanical properties of restored premolars were obtained using composite resin and dental amalgam as a core build-up material.
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Perez-Castillo, Yunierkis, Ricardo Carneiro Montes, Cecília Rocha da Silva, João Batista de Andrade Neto, Celidarque da Silva Dias, Allana Brunna Sucupira Duarte, Hélio Vitoriano Nobre Júnior, and Damião Pergentino de Sousa. "Antifungal Activity of N-(4-Halobenzyl)amides against Candida spp. and Molecular Modeling Studies." International Journal of Molecular Sciences 23, no. 1 (December 31, 2021): 419. http://dx.doi.org/10.3390/ijms23010419.
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Fungal infections remain a high-incidence worldwide health problem that is aggravated by limited therapeutic options and the emergence of drug-resistant strains. Cinnamic and benzoic acid amides have previously shown bioactivity against different species belonging to the Candida genus. Here, 20 cinnamic and benzoic acid amides were synthesized and tested for inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019. Five compounds inhibited the Candida strains tested, with compound 16 (MIC = 7.8 µg/mL) producing stronger antifungal activity than fluconazole (MIC = 16 µg/mL) against C. krusei ATCC 14243. It was also tested against eight Candida strains, including five clinical strains resistant to fluconazole, and showed an inhibitory effect against all strains tested (MIC = 85.3–341.3 µg/mL). The MIC value against C. krusei ATCC 6258 was 85.3 mcg/mL, while against C. krusei ATCC 14243, it was 10.9 times smaller. This strain had greater sensitivity to the antifungal action of compound 16. The inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019 was also achieved by compounds 2, 9, 12, 14 and 15. Computational experiments combining target fishing, molecular docking and molecular dynamics simulations were performed to study the potential mechanism of action of compound 16 against C. krusei. From these, a multi-target mechanism of action is proposed for this compound that involves proteins related to critical cellular processes such as the redox balance, kinases-mediated signaling, protein folding and cell wall synthesis. The modeling results might guide future experiments focusing on the wet-lab investigation of the mechanism of action of this series of compounds, as well as on the optimization of their inhibitory potency.
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Magen, Hila, Abraham Avigdor, Lee Nevo, Shalev Fried, Amit Gibori, Einav G. Levin, Yaniv Lustig, Eden Shkury, and Galia Rahav. "Anti-RBD IgG antibodies and neutralizing antibody levels after the second BNT162b2 dose in patients with plasma cell disorders." PLOS ONE 18, no. 5 (May 1, 2023): e0284925. http://dx.doi.org/10.1371/journal.pone.0284925.
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Patients with plasma cell disorders (PCD) are at an increased risk for severe morbidity and mortality due to COVID-19. Recent data have suggested that patients with hematological malignancies, including those with PCD, have suboptimal antibody response to COVID-19 vaccination. We compared the antibody titers of 213 patients with PCD to those of 213 immunocompetent healthcare workers after the second vaccine dose of the BNT162b2 mRNA vaccine. Blood samples were taken 2–4 weeks after the second vaccination and analyzed for anti-receptor binding-domain immunoglobulin G (RBD-IgG) antibodies and neutralizing antibodies (NA). At a median of 20 days after the second vaccine dose, 172 patients (80.8%) developed anti-RBD-IgG antibodies with a geometric mean titer (GMT) of 2.7 (95% confidence interval [CI], 2.4–3.1). In the control group 210 (98.9%) developed anti-RBD-IgG antibodies after a median of 21 days, with a GMT of 5.17 (95%CI, 4.8–5.6), p<0.0001. NA were observed in 151 patients with MM (70.9%) and in 210 controls (98.9%). The GMT of NA in patients with MM and controls was 84.4 (95% CI, 59.0–120.6), and 420.2 (95% CI, 341.4–517.1), respectively (p<0.0001). Multivariable logistic regression revealed that the number of prior therapy lines and age were significant predictors of poor humoral response among patients with MM. Injection site reaction, headache and fatigue were the most common adverse events after vaccination. Adverse events were less common in patients with MM than in controls. In conclusion, a significant percentage of patients with MM developed protecting NA to the BNT162b2 mRNA vaccine, which appears to be safe in this patient population.
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Repo, Oskari, Carlo M. Oranges, Pietro G. di Summa, Panu Uusalo, Mikael Anttinen, and Salvatore Giordano. "Scarpa Fascia Preservation to Reduce Seroma Rate on Massive Weight Loss Patients Undergoing Abdominoplasty: A Comparative Study." Journal of Clinical Medicine 12, no. 2 (January 13, 2023): 636. http://dx.doi.org/10.3390/jcm12020636.
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(1) Background: An increasing number of patients undergo bariatric surgery and seek body contouring surgery after massive weight loss (MWL). Abdominoplasty itself is associated with a high complication rate in these patients, particularly due to seroma formation. Scarpa fascia preservation (SFP) has been proven to be an efficient method of reducing seroma rates. We aimed to evaluate the possible benefits of SFP on massive weight loss patients comparatively. (2) Methods: This is a single-center retrospective comparative study encompassing 202 MWL patients operated between 2009 and 2019 at Turku University Hospital. Patients included in the study had a preoperative weight loss greater than 30 kg. Of them, 149 went through traditional abdominoplasty and 53 abdominoplasties with SFP. The primary outcome measure was seroma occurrence, while secondary outcomes included drainage amount, hospital stay, surgical site occurrence, and need for blood transfusion. (3) Results: The only statistically significant difference between groups on patients’ demographics was the sex ratio, favoring females in the control group (43:10, 81% vs. 130:19, 87%, p = 0.018). SFP significantly reduced seroma occurrence (9.4% vs. 26.2%, p = 0.011) and decreased mean drainage duration (3.7 ± 2.4 vs. 5.3 ± 3.2 days, p = 0.025). There was a trend towards lower drainage output (214.1 ± 162.2 mL vs. 341.9 ± 480.5 mL, p = 0.060) and fewer postoperative days on ward in the SFP group. Other complication incidences did not differ between the groups. The multivariable analysis did not show any significant factor for seroma formation or surgical site occurrence. (4) Conclusions: Preserving Scarpa fascia on MWL patients may result in decreased seroma occurrence and a shorter time to drain removal.
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Li, Long-Yan, Yu-Qin Zhao, Yu He, Chang-Feng Chi, and Bin Wang. "Physicochemical and Antioxidant Properties of Acid- and Pepsin-Soluble Collagens from the Scales of Miiuy Croaker (Miichthys Miiuy)." Marine Drugs 16, no. 10 (October 20, 2018): 394. http://dx.doi.org/10.3390/md16100394.
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In this report, acid-soluble collagen (ASC-MC) and pepsin-soluble collagen (PSC-MC) were extracted from the scales of miiuy croaker (Miichthys miiuy) with yields of 0.64 ± 0.07% and 3.87 ± 0.15% of dry weight basis, respectively. ASC-MC and PSC-MC had glycine as the major amino acid with the contents of 341.8 ± 4.2 and 344.5 ± 3.2 residues/1000 residues, respectively. ASC-MC and PSC-MC had lower denaturation temperatures (32.2 °C and 29.0 °C for ASC-MC and PSC-MC, respectively) compared to mammalian collagen due to their low imino acid content (197.6 and 195.2 residues/1000 residues for ASC-MC and PSC-MC, respectively). ASC-MC and PSC-MC were mainly composed of type I collagen on the literatures and results of amino acid composition, SDS-PAGE pattern, ultraviolet (UV) and Fourier-transform infrared spectroscopy (FTIR) spectra. The maximum solubility of ASC-MC and PSC-MC was appeared at pH 1–3 and a sharp decrease in solubility was observed when the NaCl concentration was above 2%. Zeta potential studies indicated that ASC-MC and PSC-MC exhibited a net zero charge at pH 6.66 and 6.81, respectively. Furthermore, the scavenging capabilities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical, superoxide anion radical and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical of ASC-MC and PSC-MC were positively correlated with their tested concentration ranged from 0 to 5 mg/mL and PSC-MC showed significantly higher activity than that of ASC-MC at most tested concentrations (p < 0.05). In addition, the scavenging capability of PSC-MC on hydroxyl radical and superoxide anion radical was higher than those of DPPH radical and ABTS radical, which suggested that ASC-SC and PSC-SC might be served as hydroxyl radical and superoxide anion radical scavenger in cosmeceutical products for protecting skins from photoaging and ultraviolet damage.
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Sabatier, Magalie, Joeska Husny, Marine Nicolas, Stèphane Dubascoux, Mary Bodis, and Ray Glahn. "Solubility and Impact of Ascorbic Acid on the in vitro Bioavailability of Two Casein-Based Iron Fortificants from Reconstituted Milk." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1836. http://dx.doi.org/10.1093/cdn/nzaa067_063.
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Abstract Objectives The two objectives were 1) to evaluate the solubility of two iron casein complexes (ICCs) under a condition mimicking gastric pH, 2) to evaluate the impact of ascorbic acid (AA) on the in vitro iron absorption of ICCs after incorporation in reconstituted whole milk powder. Methods The in vitro solubility was determined over time after addition of diluted HCl (pH 1.7), ultracentrifugation and measurement of iron appearing in the supernatant by ICP-OES (n = 2). The impact of AA on iron uptake from the Fe compounds in reconstituted milk was determined using the in vitro digestion coupled with the Caco-2 cell model and the measurement of ferritin/total protein produced by the cells (n = 3). The molar ratio of AA to iron of 2 to 1 recommended by the WHO for iron absorption optimization has been tested with an iron level corresponding to 3.3 mg Fe/serving of milk. Ferrous sulfate (FeSO4), the reference compound for iron bioavailability and micronized ferric pyrophosphate (FePP), main salt used for milk fortification were used as references. Results The dissolution test showed a rapid solubilization of iron from the ICCs i.e., >75 ± 19.3% at 5 min and >89 ± 0.3% at 90 min. The kinetics of soluble iron from the complexes were like that from FeSO4. The solubility of FePP was only 37.6 ± 4.7% at 90 min. Without AA, the iron uptake from FeSO4 was lower than expected translating into a relative in vitro bioavailability (iRBA) of FePP and of the two ICCs to FeSO4 of 66, 169 and 215%. This might be explained by a rapid conversion of soluble iron from FeSO4 into Fe3+ and insoluble iron hydroxide when the pH increased from 2 to >7 during in vitro digestion. However, with the addition of AA in the milk, iron uptake by the cells was found to be increased to levels of 341.8 ± 8.9, 124 ± 12.2, 403.1 ± 117.8 and 362.9 ± 36.9 ng ferritin/mg protein for FeSO4, FePP and the two ICCs respectively. This translates into iRBAs to FeSO4 of 36% for FePP and of 118 and 106% for the two ICCs. Conclusions The solubility and the demonstrated impact of AA on Fe uptake suggest that ICCs are absorbed to a similar amount as FeSO4 and thus provide an excellent source of Fe. Funding Sources Société des Produits Nestlé, NPTC Konolfingen, Switzerland.
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Kenny, Dorothy, and Jue Wang. "Clinical characteristics and outcomes of SARS-CoV-2 infection in patients with genitourinary cancer." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 7. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.7.
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7 Background: Cancer patients have increased risk for severe outcomes related to SARS-CoV-2 infection (COVID-19), due to their increased vulnerability to infection, older age, and comorbidities in comparison to the general population. While multiple studies have been completed examining outcomes of COVID-19 infection in cancer patients overall, there has been limited investigation into the outcomes of COVID-19 infection in patients with genitourinary (GU) cancers. Methods: We completed a single institution retrospective study to examine the outcomes of adults with GU cancers and COVID-19 infection from March 10, 2020 to June 15, 2022. Baseline data included age, sex, BMI, type of malignancy, cancer status (stable or progressive disease, in remission), current and previous anticancer therapy received, and comorbidities. Results: Eighty-four patients with a GU cancer diagnosis and laboratory-confirmed SARS-CoV-2 infection were identified. Seventy-nine (94%) were male and the median age was 64 years (range 24-91). Forty-four (52%) were non-Hispanic white, 28 (33%) were Hispanic, and 11 (13%) were African-American. Prostate cancer was the most common (n = 45), followed by renal cell carcinoma (n = 20), testicular (n = 9), bladder (n = 6), and penile cancer (n = 3). Eight patients had ≥2 episodes of COVID-19 infection. Sixty-three percent of patients were unvaccinated at the time of infection, while 37% of patients had breakthrough infection. Hospitalization was required for 39.3% (n = 33), with 4.8% (n = 4) requiring ICU admission. Of the patients requiring hospitalization, 26.2% (n = 22) died. Hospitalization was associated with having ≥2 comorbidities (OR 18.6 [95% CI, 3.1-111.8], p<0.01) and receiving active cancer treatment (OR 12.4 [95% CI, 1.92-79.7], p< 0.01). Mortality was associated with advanced age (OR 21.7 [95% CI, 1.40-341.7], p=0.03) and ≥2 comorbidities (OR 19.2 [95% CI, 3.02-122.5], p=0.02). Vaccination was negatively associated with both hospitalization (OR 0.04 [95% CI, 0.02-0.91], p=0.04) and mortality (OR 0.14 [95% CI, 0.02-0.84], p=0.03). Conclusions: Among patients with GU cancer, advanced age and comorbidities are associated with adverse outcomes of COVID-19 infection; vaccination is protective. With the emergence of variants and waning immunity of vaccines, our findings highlight the importance of development and implementation of enhanced mitigation strategies in cancer patients, especially those undergoing active cancer treatment.
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Alkhalidy, Hana, Wafaa Sarhan, Mohammad Al-Gharaibeh, Aseel Hasan, and Dongmin Liu. "Mentha Longifolia L. Improves Antioxidant Status, Glucose Tolerance, Insulin Resistance and Hepatic Glucose Production In Diet-Induced Obesity." Current Developments in Nutrition 5, Supplement_2 (June 2021): 294. http://dx.doi.org/10.1093/cdn/nzab037_004.
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Abstract Objectives Obesity is associated with several metabolic abnormalities including insulin resistance (IR), which is a key risk factor of type 2 diabetes mellitus (T2DM). Oxidative stress is linked to both obesity and IR development. Improving antioxidant status using medicinal plants or their bioactive components can be a safe and low-cost alternative approach to reduce obesity and IR thus T2DM development. This study aims to evaluate the antioxidant activities of Mentha longifolia L. (M. longifolia) leaf powder and oil extract on obesity-induced metabolic abnormalities. Methods High-fat-sucrose diet (HFS)-induced obese Wistar rats were orally given M. longifolia essential oil (50 mg/kg), leaf powder (120 mg/kg), or vehicle for 6 weeks. Bodyweight and calorie intake were recorded periodically, and glucose and pyruvate tolerance were evaluated. At the end of the study, plasma insulin and triglyceride levels were measured, and organs weight and the degree of adiposity were determined. Antioxidant status for the plasma was measured using plasma ferric ion reducing antioxidant power test (FRAP). Results M. longifolia leaf powder and oil extract improved glucose tolerance, and hepatic glucose production after being challenged with glucose or pyruvate compared to untreated obese rats. M. longifolia reduced IR (HOMA-IR: oil = 2.30 ± 0.279, powder = 2.13 ± 0.057, HFS = 2.54 ± 0.136). Antioxidant status was also improved in rats treated with M. longifolia (FRAP: oil = 300.5 ± 25.4, powder = 341.8 ± 47.2, HFS = 263.5 ± 13.0). These outcomes were not associated with changes in body weight, calorie intake, adiposity, or plasma triglycerides. Conclusions M. longifolia oil and powder improved the antioxidant status and ameliorated HFS diet-induced metabolic abnormalities, suggesting that this plant a promising natural agent for reducing the risk of T2DM. Further studies are needed to elucidate the mechanism of this action. Funding Sources Deanship of Scientific Research at Jordan University of Science and Technology.
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Guo, X. Y., X. H. Zhu, Y. Long, and D. J. Huang. "Spatial variations in the Kuroshio nutrient transport from the East China Sea to south of Japan." Biogeosciences Discussions 10, no. 4 (April 16, 2013): 6737–62. http://dx.doi.org/10.5194/bgd-10-6737-2013.
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Abstract. Based on absolute geostrophic velocity calculated from repeated hydrographic data of 39 cruises from 2000 to 2009 and nitrate concentrations measured at the same sections from 1964 to 2011, we obtained temporally averaged nitrate flux (the product of velocity and nitrate concentration) and nitrate transport (integration of flux over a section) through 4 sections along the Kuroshio path from the East China Sea (sections PN and TK) to south of Japan (sections ASUKA and 137E). In addition, we examined section OK east of the Ryukyu Islands in order to understand the contribution of Ryukyu Current to the Kuroshio nutrient transport south of Japan. The mean nitrate flux shows a subsurface maximum core with a value of 10, 10, 11, 11, and 6 mol m–2 s–1 at sections PN, TK, ASUKA, 137E, and OK, respectively. The depth of subsurface maximum core changes among five sections and is approximately 400, 500, 500, 400, and 800 m at sections PN, TK, ASUKA, 137E, and OK respectively. The mean downstream nitrate transport is 199.3, 176.3, 909.2, 1385.5, and 341.2 kmol m–1 at sections PN, TK, ASUKA, 137E, and OK respectively. The nutrient transports at these sections suggest the presence of Kuroshio nutrient stream from its upstream region to downstream. The deep current structure of Ryukyu Current (section OK) makes it contribute more nitrate transport than the Kuroshio in the East China Sea (section TK) to the Kuroshio south of Japan. In addition, the positive difference between the downstream nitrate transport through section ASUKA and the sum of nitrate transports through sections TK and OK, as well as the positive difference of downstream nitrate transport between sections 137E and ASUKA, suggest that the Kuroshio recirculation significantly intensifies the downstream (eastward) nitrate transport by the Kuroshio.
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Al-Gharawi, Firas Abdul Karim Makki, Hamza Nouri Al-Dulaimi, and Naim Shteiwi Matar. "Effect of Adding Different Levels of Potassium on Some Vegetative Growth Characteristics of Maize Under Water Stress Conditions." IOP Conference Series: Earth and Environmental Science 1262, no. 5 (December 1, 2023): 052054. http://dx.doi.org/10.1088/1755-1315/1262/5/052054.
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Abstract A field experiment was conducted for the autumn season in 2022 in an agricultural land in the province of Raranjia (Hamzawiyah), 10 km south of Babylon Governorate, the center of Hilla, in soil with sandy clay mixed texture to improve the growth efficiency of the Maize plants (Zea mays L.) Fajr 1 cultivar under water stress conditions by the effect of irrigation durations and the addition of different amounts of potassium sulfate. The experiment was designed in randomized complete block design (R.C.B.D) with three replicates. in a split - plots arrangement, as the irrigation periods included four levels, namely irrigation every (6, 8, 10 and 12) days as a main factor, while potassium sulfate included four levels (0, 150, 200 and 250) kg.h-1. The results achieved the duration of irrigation every 8 days significant superiority in the average on the highest, leaf area, leaves content of chlorophyll and the dry matter of plant, which amounted to 177.8 cm, 519.3 cm 2, 47.9 SPAD and 428.5 g, while the duration of irrigation every 12 days was significantly reduced in reducing some vegetative growth characteristics, as the average yield of dry matter reached 341.9 g and the level of potassium sulfate added significantly affected the increase in vegetative of growth indicators such as plant height, leaf area, dry weight and leaf content of chlorophyll, and the potassium level of 250 kg.h-1 achieved the highest values among other potassium levels for the same traits, reaching 180.3 cm, 522.9 cm2, 432.1 g and 47.9 SPAD respectively, while the interaction between the two factors had a significant impact on most of the studied traits and gave interference Irrigation periods 8 days and potassium addition 250 kg.ha -1.
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Sheludchenko, Vyacheslav M., and Alina K. Drakon. "Influence of complex application of heliox therapy and acupuncture on maximally corrected visual acuity in patients with acute form of central serous chorioretinopathy." Russian Journal of Physiotherapy, Balneology and Rehabilitation 21, no. 2 (December 3, 2022): 91–95. http://dx.doi.org/10.17816/rjpbr111036.
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BACKGROUND: Central serous chorioretinopathy is a socially significant problem, as it is one of the most common diseases of the retina. It is more common in males of working age.
AIM: to evaluate the effect of the combined use of heliox therapy and acupuncture on the most corrected visual acuity in patients with acute central serous chorioretinopathy.
MATERIAL AND METHODS: The study included 34 men (34 eyes) with central serous chorioretinopathy, whose mean age was 362.3 years. The patients were divided into 2 groups comparable according to clinical and laboratory data: the main one ― 22 people, average age 323.1 years, who in the first two weeks received a complex of physiotherapeutic treatment, including: heliox 21, for a course of 10 daily procedures and acupuncture, also for a course of 10 daily procedures, and a control ― 12 people, average age 341.5 years, who, after consulting a neurologist, were prescribed medication (light sedatives, the Nutrof vitamin complex, diuretics 1 time in 3 days with restoration of electrolyte balance, alcohol restriction), which served as a background in the main group.
Visometry (visual acuity) was used to assess the effectiveness of treatment. Before treatment, after 2 weeks, after 1 month, 3 months, 6 months, 12 months.
RESULTS: Before treatment in patients with acute central serous chorioretinopathy, the maximum corrected visual acuity was reduced by 44.2% compared to the norm ― 0.950.05 (p 0.001) and comparable in the main group 0.540.05 and in the control group 0.530.05 (p=0.901). The maximum increase in visual acuity in patients of the main group was already two weeks later, with a subsequent increase in the indicator during the year, approaching the normal values at the last observation point (1 year). In addition, all patients after treatment noted a decrease in the intensity or exclusion of metamorphopsia. In the maximally corrected visual acuity control group, significantly less significant results were obtained at all control points.
CONCLUSION: Under the influence of the combined use of heliox therapy and acupuncture in patients with acute form of central serous chorioretinopathy, a more pronounced and persistent increase in maximally corrected visual acuity occurred compared to drug treatment.
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Zalinko, G. R., V. J. Racz, B. G. Rossnagel, D. A. Christensen, and J. J. McKinnon. "Performance and carcass characteristics of steers fed a low acid-detergent lignin hull, high-oil groat oat in growing and finishing diets." Canadian Journal of Animal Science 89, no. 4 (December 1, 2009): 521–30. http://dx.doi.org/10.4141/cjas09023.
Full textAbstract:
Two trials were conducted to evaluate the performance and carcass traits of steers fed a low acid detergent lignin hull, high oil groat (LLH-HOG) oat in cattle diets. In trial 1, 400 steers (275.4 ± 20.8 kg) were fed one of two diets with barley or LLH-HOG oat at 37.8% of the diet (DM basis). Dry matter intake (DMI) was lower (P = 0.02) (7.49 vs. 7.72 kg d-1) and gain to feed improved (P < 0.01) (0.171 vs. 0.159 kg) for steers fed the oat-based diet. Calculated NEm (1.80 and 1.71 Mcal kg-1) and NEg (1.17 and 1.09 Mcal kg-1) values were greater for the oat-based diet. In trial 2, 240 steers (341.7 ± 18.1 kg) were fed one of three diets consisting of 88.2% barley, corn or oat grain, 5.1% barley silage and 6.7% supplement (DM basis). During finishing, steers on the oat diet had lower (P < 0.01) Average daily gain than barley- or corn-fed cattle (1.40, 1.69 and 1.84 kg d-1, respectively) reflecting lower (P < 0.01) DMI (9.56, 10.84 and 11.56 kg d-1, respectively). Ultrasound fat and longissimus dorsi (l. dorsi) area, carcass weight and dressing percentage were lower (P < 0.01) for steers fed the oat diet. Stearic acid content of the l. dorsi of oat-fed cattle was greater (P < 0.01) than barley- or corn-fed cattle. The ratio of polyunsaturated to saturated fatty acids in the muscle of oat- and corn-fed cattle was greater (P = 0.01) than that of barley-fed cattle. Results indicate that the energy value of the LLH-HOG oat is equivalent or superior to that of barley for growing cattle; however, research is required to identify why feed intake of finishing cattle fed this grain source is reduced. Key words: Low lignin hull, high-oil groat oat, barley, corn, cattle performance, carcass traits
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Muliarta, Made, Ketut Tirtayasa, Putu Yuda Prabawa, and Kadek Adit Wiryadana. "Tamarillo Consumption Associated with Increased Acetylcholinesterase Activity and Improved Oxidative Stress Markers in Farmers Exposed to Daily Pesticide-related Activities in Baturiti, Bali, Indonesia." Open Access Macedonian Journal of Medical Sciences 8, E (May 20, 2020): 244–50. http://dx.doi.org/10.3889/oamjms.2020.3265.
Full textAbstract:
BACKGROUND: The behavior of pesticide use that does not meet the standards will increase the risk of pesticide intoxication among farmers. The main content of pesticides, namely, organophosphates and carbamate, has been widely known to be the main culprit of the negative side effect through inhibition of the acetylcholinesterase (AChE) enzyme. However, this effect theoretically could be reduced by exogenous antioxidants properties provided in tamarillo fruit.
AIM: This study aims to determine the effect of tamarillo consumption on the AChE activity and biomarkers of oxidative stress among farmers who exposed daily pesticide-related activity.
METHODS: A randomized, open-label clinical trial was conducted among 40 farmers in the Baturiti, Tabanan Regency, Bali, Indonesia, during March–August 2018. The respondents were randomly divided into two groups: (1) Groups of farmers without tamarillo juice supplementation (control), and groups of farmers who were given pure tamarillotamarillo juice 250 ml/day every day for 2 weeks (intervention). Measurement of AChE, malondialdehyde (MDA), and superoxide dismutase (SOD) levels was carried out at the beginning and the end of the study. Data were analyzed using SPSS version 17 for windows.
RESULTS: Bioactive compound assessment found several antioxidant properties such as flavonoid, tocopherol, polyphenol, β-carotene, ascorbic acid, citric acid, and anthocyanin. The study participants were dominated by male and the distribution of gender between control and intervention groups was comparable (p > 0.05). There were also no significant differences in age, height, weight, body mass index, land area, duration of being farmers, spraying frequency, and smoking history (p > 0.05). However, bivariate analysis between control and intervention groups found a statistically significant difference in SOD (MD: 23.31 ± 15.89 nmol/l; 95% CI: 14.13–32.49; p < 0.0001), MDA (MD: 81.82 ± 62.45 nmol/l; 95% CI: 45.76–117.88; p < 0.0001), and AChE (MD: 341.61 ± 206.44 nmol/min/ml; p < 0.0001) levels.
CONCLUSION: Tamarillo consumption associated with increased AChE activity and improved oxidative stress through increased SOD and decreased MDA levels among farmers.