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Journal articles on the topic '341.824 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Groot, Peter C., and Jim van Os. "Successful use of tapering strips for hyperbolic reduction of antidepressant dose: a cohort study." Therapeutic Advances in Psychopharmacology 11 (January 2021): 204512532110393. http://dx.doi.org/10.1177/20451253211039327.

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Background: Tapering strips facilitate antidepressant discontinuation, allowing for personalised titration of discontinuation to the intensity of withdrawal. A tapering strip consists of antidepressant or other medication, packaged in a 28-day roll of daily pouches, each with the same or slightly lower dose than the one before. Previous studies demonstrated 70% real-world effectiveness of tapering strips. Here, we present a third, questionnaire-based retrospective cohort study in a large sample. Methods: Patients whose doctor had prescribed tapering strips between October 2015 and December 201

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Stilgenbauer, Stephan, Barbara F. Eichhorst, Raymonde Busch, et al. "Biologic and Clinical Markers for Outcome after Fludarabine (F) or F Plus Cyclophosphamide (FC) - Comprehensive Analysis of the CLL4 Trial of the GCLLSG." Blood 112, no. 11 (2008): 2089. http://dx.doi.org/10.1182/blood.v112.11.2089.2089.

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Abstract The CLL4 trial evaluated 1st line treatment with F or FC among 375 CLL patients up to 65 years (Eichhorst et al., Blood, 2006). Updated follow-up (median 52.8 months (mo) for alive patients) revealed 50.4% events for progression-free survival (PFS) and 24.5% for overall survival (OS). Comparing the treatment arms, significant differences were observed in favor of FC for CR (19.9% vs 5.9%, p&lt;.001), CR+PR (94.7% vs 82.4%, p&lt;.001), and PFS (median 67.8 vs 43.7 mo, p=.002) but not for OS (median n.r. vs 84.6 mo, p=.191). The incidences of genomic aberrations by FISH (n=321)

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Perrotti, Andrea, Daniel Reichart, Giuseppe Gatti, et al. "Hospital Volume and Outcome after Bilateral Internal Mammary Artery Grafting." Heart Surgery Forum 23, no. 4 (2020): E475—E481. http://dx.doi.org/10.1532/hsf.2745.

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Background: Bilateral internal mammary artery (BIMA) grafting largely is underutilized in patients undergoing coronary artery bypass grafting (CABG), partly because of the perceived increased complexity of the procedure. Aims: In this study, we evaluated whether BIMA grafting can safely be performed also in centers, where this revascularization strategy infrequently is adopted. Methods: Out of 6,783 patients from the prospective multicenter E-CABG study, who underwent isolated non-emergent CABG from January 2015 to December 2016, 2,457 underwent BIMA grafting and their outcome was evaluated in

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Schäfer, Stefan B., Claudia Rudolph, Martin Kolodziej, Frank Mauermann, Fritz Christian Roller, and Gabriele Anja Krombach. "Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 191, no. 11 (2019): 1015–25. http://dx.doi.org/10.1055/a-0881-3113.

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Purpose Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps. Materials and Methods In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. A visual assessment of the image quality was performed by two radiologists on the basi

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Diniz, Genilson L., Reginaldo G. Nobre, Geovani S. de Lima, Leandro de P. Souza, Hans R. Gheyi, and Mizael N. V. de Medeiros. "Physiological indices and growth of ‘Gigante Amarelo’ passion fruit under salt stress and silicate fertilization." Revista Brasileira de Engenharia Agrícola e Ambiental 24, no. 12 (2020): 814–21. http://dx.doi.org/10.1590/1807-1929/agriambi.v24n12p814-821.

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ABSTRACT Abiotic stresses are responsible for the loss of agricultural production in different regions, especially in semiarid regions, which have long periods of drought and high evapotranspiration, leading to the use of saline water as an alternative for the expansion of irrigated areas. In this context, the objective was to evaluate the physiological indices and the growth of the ‘Gigante Amarelo’ passion fruit as a function of the salinity of irrigation water and fertilization with silicon. A randomized block design was used in a 5 x 2 factorial scheme, whose treatments consisted of five e

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Szenasi, G., G. Kottra, P. Bencsath, and L. Takacs. "Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats." American Journal of Physiology-Renal Physiology 254, no. 1 (1988): F32—F37. http://dx.doi.org/10.1152/ajprenal.1988.254.1.f32.

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The effect of acute renal denervation (RD) on water (V), sodium (UNaV), and potassium excretion (UKV) from the hypertrophied and control kidney was studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx). V, UNaV, and UKV from the hypertrophied kidney were similar before and after RD or sham RD. In contrast, in SNx rats, left RD resulted in an ipsilateral increase in V (from 2.76 +/- 0.39 to 5.31 +/- 0.99 microliters.min-1.g-1), UNaV (from 109 +/- 36 to 857 +/- 331 nmol.min-1.g-1), and UKV (from 144

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Austin, Publishing Group. "The Role of Calcium in Augmenting the Efficacy of Primary Homeostasis after Hemorrhagic Shock." Annals of Hematology & Oncology 10, no. 1 (2023): 1415. https://doi.org/10.26420/annhematoloncol.2023.1415.

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Abstract <strong>Background:</strong> Traumatic Hemorrhagic Shock (THS) causes hypocalcemia (Ca). This study assesses how low Ca affects platelet (Plt) function. <strong>Study Design:</strong> A research registry was queried for 555 studies on 341 patients (pts) with THS requiring 14.2 units RBC, 8.4 units FFP, 3.6 units Plt, and 18.9 mEq Ca by end of O.R. (7.3 hours). Factors analyzed included Plt count, Ca, Bleeding Time (BT), Plt aggregation with ADP (PAadp) and collagen (PAcol), including Max PA, T1/2 PA, and rate PA, plus platelet release factors, beta thromboglobulin (BTG) and

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Chambers, Caitlin C., T. Sean Lynch, Daniel B. Gibbs, et al. "Superior Labrum Anterior-Posterior Tears in the National Football League." American Journal of Sports Medicine 45, no. 1 (2016): 167–72. http://dx.doi.org/10.1177/0363546516673350.

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Background: Shoulder disorders are common in football players, with up to 50% of National Football League (NFL) recruits reporting a history of shoulder injuries. Superior labrum anterior-posterior (SLAP) tears are an entity with well-described detrimental effects on return to play in overhead-throwing athletes but with minimal data in contact athletes. Purpose: To identify the incidence, predisposing factors, and effect of SLAP tears in NFL athletes and prospects as well as the treatment patterns of NFL team physicians. Study Design: Descriptive epidemiology study. Methods: This study was a c

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Mariños Sánchez, Evelyn, Poul Espino Alvarado, Liliana Rodriguez, and Elliot Barreto Acevedo. "Manifestaciones neurológicas asociadas a COVID-19 en el Hospital Edgardo Rebagliati Martins, Perú." Revista de Neuro-Psiquiatria 83, no. 4 (2021): 243–56. http://dx.doi.org/10.20453/rnp.v83i4.3890.

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La enfermedad causada por el coronavirus 2 asociado al síndrome respiratorio agudo grave (SARS-CoV-2), se conoce formalmente como Coronavirus Disease 2019 (COVID-19). Su principal foco de infección es el sistema respiratorio, pero se han descrito también manifestaciones neurológicas. Objetivo: Describir las manifestaciones neurológicas en pacientes con COVID-19 en el hospital Edgardo Rebagliati Martins. Material y Métodos: Estudio observacional, descriptivo, transversal, empleando los registros médicos electrónicos de los pacientes hospitalizados con COVID -19 y dados de alta durante el period

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Tomizawa, Daisuke, Akio Tawa, Tomoyuki Watanabe, et al. "Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)." Blood 120, no. 21 (2012): 2615. http://dx.doi.org/10.1182/blood.v120.21.2615.2615.

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Abstract Abstract 2615 Background: Infants (age <1 year) with AML are naturally vulnerable to intensive cytotoxic therapy, and we have previously reported unacceptably high early death rate mainly due to pulmonary complications among the first 32 infants (28 eligible) enrolled in the JPLSG AML-05 study, which prompted us to suspension of patient accrual and protocol amendment (Tomizawa D. 52ndASH abstract #2146). Seventeen additional infants were enrolled after the amendment, and here we report the final outcome of total 45 infants with AML treated on AML-05 study. Patients & Methods: J

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Mustafaev, A. R. "The epizootic situation of bovine leukemia in the Republic of Dagestan in 2023." International Journal of Veterinary Medicine, no. 2 (June 28, 2024): 17–23. http://dx.doi.org/10.52419/issn2072-2419.2024.2.17.

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Bovine enzootic leukemia (EBLV) remains an acute problem for animal husbandry in many regions of Russia. Based on this, the goal was set: to study the epizootic situation of bovine leukemia in the Republic of Dagestan. The material for the study was taken from the official source of the Veterinary Committee of the Republic, as well as supplemented with our own serological blood tests for bovine leukemia virus (bovine leukemia). Laboratory tests for the detection of antibodies to BLV in RID were carried out according to the "Guidelines for the diagnosis of bovine leukemia" (2000). Research resu

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Gonçalves, Ana, Rui Teixeira, Helena Sant’Ovaia, and Fernando Noronha. "Zircon U–Pb Dating and Lu–Hf Isotopic Composition of Some Granite Intrusions in Northern and Central Portugal: Constraints on the Emplacement Age and Nature of the Source Rocks." Minerals 14, no. 6 (2024): 573. http://dx.doi.org/10.3390/min14060573.

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Freixo de Numão (FNG) and Capinha (CG) granites are prominent intrusions in the Douro Group (northern Central Iberian Zone, CIZ) and Beiras Supergroup (southern CIZ) metasediments, respectively. U-Pb dating revealed crystallization ages of 306 ± 2 Ma for FNG and 301 ± 3 Ma for CG, whereas Lu–Hf systematics has shown ɛHft values ranging from −4.5 to +0.6 and from −5.5 to +0.3 in FNG and CG autocrysts, respectively, suggesting that they originate from heterogeneous crustal anatectic melts, but a direct mantle-derived material contribution can also be considered. The isotopic data of inherited zi

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Dawson, Samuel J., and Lee Herrington. "Improving Single-Legged–Squat Performance: Comparing 2 Training Methods With Potential Implications for Injury Prevention." Journal of Athletic Training 50, no. 9 (2015): 921–29. http://dx.doi.org/10.4085/1062-6050-50.9.03.

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Context Poor dynamic limb alignment during loading tasks has links to the development of knee injuries, including patellofemoral pain and anterior cruciate ligament injury. Therefore, modalities to improve limb alignment during loading tasks are thought to reduce loading through these structures and potentially prevent injury. Objective To compare hip-strengthening and skill-acquisition training to examine if they can improve lower limb biomechanics, potentially preventing injury, and to examine whether changes demonstrated can be maintained after 6 weeks of no practice. Design Controlled labo

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Ahmad, Muhammad Zahid, Muhammad Sabir Ashraf, Muhammad Asif, Nauman Ahmed, Shahjehan Khan, and Aftab Ahmed Channa. "Efficacy Comparison of Intralesional inj.Interferon Alpha 2B (2 MU) against Intralesional Inj.Interferon Alpha 2B (3 MU) in Treatment of Peyronie’s Disease." Pakistan Journal of Medical and Health Sciences 16, no. 5 (2022): 1042–44. http://dx.doi.org/10.53350/pjmhs221651042.

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Introduction: In Peyronie’s Disease, fibrous plaque is formed which has an excessive amount of collagen, fibroblastic proliferation and elastin framework alteration. Objective: To compare the effect of Intralesional Inj.Interferon alpha 2b (2 MU) against Intralesional Inj. Interferon alpha 2b (3 MU) on plaque size, penile deviation, erectile function and pain during erection in patients having Peyronie's disease Methods: It was comparative interventional/longitudinal study, conducted at Department of Urology, Kot Khawaja Saeed hospital, Lahore and Department of Urology, DHQ hospital Sheikhupur

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Mahdi, Muna Iskandar, and Kassim Hassan Kadhim. "A batch and cloud point extraction kinetic spectrophotometric method for determining trace and ultra trace amounts of Benzodiazepine drugs (Clonazepam and Nitrazepam) in pure and pharmaceutical preparations." Current Issues in Pharmacy and Medical Sciences 33, no. 1 (2020): 21–31. http://dx.doi.org/10.2478/cipms-2020-0006.

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AbstractUtilizing the batch Diazotization coupling reaction and the cloud point extraction kinetic spectrophotometric method, trace and Ultra trace amounts from reducing Nitrazepam and Clonazepam were evaluated by way of using 2,5-dimethoxyaniline as a new Chromogenic reagent to give colored products (red) in acidic medium which have a maximum absorption at 500 and 502 nm, respectively. In the work, the analytical data of batch and cloud point for Nitrazepam and Clonazepam depended on initial rate and fixation time. This involved concentrations of (0,3-9), (0.05-1.2), (0.5-10) and (0.025-1) µg

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Nguyen, Paul L., Alphonse G. Taghian, Matthew S. Katz, et al. "Breast Cancer Subtype Approximated by Estrogen Receptor, Progesterone Receptor, and HER-2 Is Associated With Local and Distant Recurrence After Breast-Conserving Therapy." Journal of Clinical Oncology 26, no. 14 (2008): 2373–78. http://dx.doi.org/10.1200/jco.2007.14.4287.

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Purpose To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy. Patients and Methods We studied 793 consecutive patients with invasive breast cancer who received BCT from July 1998 to December 2001. Among them, 97% had pathologically negative margins of resection, and 90% received adjuvant systemic therapy. No patient received adjuvant trastuzumab. Receptor status was used to approximate subtype: estrogen receptor (ER) or progesterone receptor (PR) positive and human epidermal growth factor rece

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Friedlander, Anne L., Gretchen A. Casazza, Michael A. Horning, Thomas F. Buddinger, and George A. Brooks. "Effects of exercise intensity and training on lipid metabolism in young women." American Journal of Physiology-Endocrinology and Metabolism 275, no. 5 (1998): E853—E863. http://dx.doi.org/10.1152/ajpendo.1998.275.5.e853.

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We examined the effects of exercise intensity and training [12 wk, 5 days/wk, 1 h, 75% peak oxygen consumption (V˙o 2 peak)] on lipolysis and plasma free fatty acid (FFA) flux in women ( n = 8; 24.3 ± 1.6 yr). Two pretraining trials (45 and 65% ofV˙o 2 peak) and two posttraining trials [same absolute workload (65% of oldV˙o 2 peak; ABT) and same relative workload (65% of newV˙o 2 peak; RLT)] were performed using infusions of [1,1,2,3,3-2H]glycerol and [1-13C]palmitate. Pretraining rates of FFA appearance (Ra), disappearance (Rd), and oxidation (Rox p) were similar between the 65% (6.8 ± 0.6, 6

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Cao, Hua, Shaojun Jiang, Meina Lv, Tingting Wu, Wenjun Chen, and Jinhua Zhang. "Effectiveness of the Alfalfa App in Warfarin Therapy Management for Patients Undergoing Venous Thrombosis Prevention and Treatment: Cohort Study." JMIR mHealth and uHealth 9, no. 3 (2021): e23332. http://dx.doi.org/10.2196/23332.

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Background Over the years, the internet has enabled considerable progress in the management of chronic diseases, especially hypertension and diabetes. It also provides novel opportunities in online anticoagulation management. Nevertheless, there is insufficient evidence regarding the effectiveness of online anticoagulation management. Objective This study explored the effectiveness and safety of warfarin management via the Alfalfa app, so as to provide evidence in support of anticoagulant management through online services. Methods In this retrospective, observational cohort study, 824 patient

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Gandi, Carlo, Angelo Totaro, Riccardo Bientinesi, et al. "Purely Off-Clamp Partial Nephrectomy: Robotic Approach Better than Open Using a Pentafecta Outcome with Propensity Score Matching." Journal of Clinical Medicine 11, no. 21 (2022): 6241. http://dx.doi.org/10.3390/jcm11216241.

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Partial nephrectomy (PN) is the gold standard treatment for localized renal masses. Robot-assisted PN (RAPN) has overcome laparoscopy’s technical limitations, greatly expanding the indications of minimally invasive PN, which is dominated by renal artery clamping in almost all published series. We compared off-clamp RAPN (OFFC-RAPN) with the open approach (OFFC-OPN) using propensity score (PS) matching. A favourable pentafecta outcome was defined as a combination of no positive surgical margins (PSM), no complications of Clavien–Dindo (CD) grade ≥ 3, post-operative eGFR loss <10%, length of

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Offer, J. E., and N. W. Offer. "Calcium hydroxide treatment of malt distillers' grains 2. Effects on apparent digestibilityin vivo, intake and performance in sheep." Animal Science 55, no. 2 (1992): 209–18. http://dx.doi.org/10.1017/s0003356100037478.

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AbstractThe effects of calcium hydroxide (Ca(OH)2)treatment of malt distillers' grains (MDG) on apparent digestibilityin vivo, food intake and lamb performance were measured in three experiments. Experiment 1 measured effects on intake and apparent digestibility of wet MDG either untreated (C), mineralized with a high-calcium mineral (M), Ca(OH)2treated at ambient temperature (L) or at 70°C for 72 h (LH) and offeredad libitumto mature wether sheep (approx. 75 kg live weight). Dry matter (DM) intakes for MDG were 1251,1585,1838 and 1889 (s.e. 93) g/day for C, M, L and LH respectively when given

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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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Cappellini, Maria Domenica, Norbert Gattermann, Vip Viprakasit, et al. "Transfusion History, Iron Chelation Practices and Status of Iron Overload across Various Transfusion-Dependent Anemias: Data from the Large- Scale, Prospective, 1-Year EPIC Trial." Blood 112, no. 11 (2008): 3880. http://dx.doi.org/10.1182/blood.v112.11.3880.3880.

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Abstract Background: The prospective, 1-yr multicenter EPIC trial evaluated the efficacy and safety of once-daily oral deferasirox (Exjade®) in more than 1700 patients (pts) with transfusion-dependent anemias. Data were collected from each patient at enrollment, providing an insight into transfusion history, body iron burden, and the nature and success of previous chelation therapy in a large group of pts with iron overload previously treated with chelation therapy. Methods: Enrolled pts were aged ≥2 yrs, had transfusion-dependent anemia and serum ferritin (SF) levels of ≥1000 ng/mL, or <10

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Lanzillo, B., C. Crisci, F. Crispi, and A. M. Saltalamacchia. "ELECTROPHYSIOLOGICAL ABNORMALITIES IN DIABETIC PATIENTS." Journal of the Peripheral Nervous System 5, no. 1 (2000): 42. http://dx.doi.org/10.1046/j.1529-8027.2000.00513-31.x.

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We studied 476 patients affected by diabetes: 166 male (mean age 61.6 ± 10 years, range 27–91) and 310 female (mean age 61.5 ± 8.4 years, range 25–82). Mean disease duration was 11.3 ± 7.6 years, range 0.3–37).All patients underwent surface motor and sensory nerve conduction along median, popliteal, and sural nerve.Results. Median nerve: in 3.1% of subjects sensory action potentials (SAP) was absent; sensory nerve conduction velocity (SNCV) was reduced in 41.8% in distal segment and in 27.5% in the proximal segment. Motor nerve conduction (MNCV) was reduced in 29.9% of the subjects.Sural nerve

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Binkley, Michael S., M. Shahzad Rauf, Sarah A. Milgrom, et al. "Stage I-II nodular lymphocyte-predominant Hodgkin lymphoma: a multi-institutional study of adult patients by ILROG." Blood 135, no. 26 (2020): 2365–74. http://dx.doi.org/10.1182/blood.2019003877.

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Abstract Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon histologic variant, and the optimal treatment of stage I-II NLPHL is undefined. We conducted a multicenter retrospective study including patients ≥16 years of age with stage I-II NLPHL diagnosed from 1995 through 2018 who underwent all forms of management, including radiotherapy (RT), combined modality therapy (CMT; RT+chemotherapy [CT]), CT, observation after excision, rituximab and RT, and single-agent rituximab. End points were progression-free survival (PFS), freedom from transformation, and overall survival (O

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Biddeci, Giada, Elena Varotto, Maria Paola Boaro, et al. "Features of Avascular Osteonecrosis in Children Treated for Acute Lymphoblastic Leukaemia: Experience in a Single Center." Blood 128, no. 22 (2016): 5158. http://dx.doi.org/10.1182/blood.v128.22.5158.5158.

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Abstract Because survival of pediatric acute lymphoblastic leukaemia (ALL) has improved in the last years, adverse effects acquire increasing importance. Avascular osteonecrosis (ON) is a long term complication of ALL treatment affecting the patients' quality of life. Its pathogenesis recognizes multiple factors (age, race, genetics, chemotherapies and steroids). The different roles of dexamethasone (DXM) versus prednisone (PDN) is still under discussion, as dosages and rate of administration. The prevalence of ON varies in different series (0.43-17.6%). It affects mostly the weight-bearing ep

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Kantathut, Narongrit, Piya Cherntanomwong, Siam Khajarern, and Parinya Leelayana. "Lactated Ringer’s as a Base Solution for del Nido Cardioplegia." Journal of ExtraCorporeal Technology 51, no. 3 (2019): 153–59. http://dx.doi.org/10.1051/ject/201951153.

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Unavailability of Plasma-Lyte A precludes the utility of traditional del Nido cardioplegia in many countries. This observational study aimed to evaluate myocardial preservation and clinical outcomes when using lactated Ringer’s solution as the base solution for del Nido cardioplegia as compared with our institute’s standard blood cardioplegia strategy. Eighty-nine adult patients underwent cardiac surgery for acquired heart disease from February 2017 to November 2017 either with del Nido cardioplegia (n = 44) or blood cardioplegia (n = 45). Clinical data and outcomes were compared. Patient char

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Scher, H. I., C. Logothetis, A. Molina, et al. "Improved survival outcomes in clinically relevant patient subgroups from COU-AA-301, a phase III study of abiraterone acetate (AA) plus prednisone (P) in patients with metastatic castration-resistant prostate cancer (mCRPC) progressing after docetaxel-based chemotherapy." Journal of Clinical Oncology 29, no. 7_suppl (2011): 4. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.4.

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4 Background: AA is a selective androgen biosynthesis inhibitor that blocks the action of CYP17. Preclinical and early clinical studies suggest that AA potently inhibits persistent androgen synthesis from adrenal and intratumoral sources, thus suppressing an important growth stimulus for mCRPC. Methods: COU-AA-301 ( NCT00638690 ) is an international, randomized, double blind study of AA (1,000 mg + P 5 mg po BID) vs placebo + P administered to men with mCRPC progressing after docetaxel-based chemo. OS is the primary endpoint. Patients treated with previous ketoconazole or > 2 prior chemo re

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Turan, Volkan, Matteo Lambertini, Dong-Yun Lee, et al. "Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data." Journal of Clinical Oncology 39, no. 18 (2021): 2016–24. http://dx.doi.org/10.1200/jco.20.02880.

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PURPOSE To determine whether germline BRCA (g BRCA) pathogenic variants are associated with decreased ovarian reserve. MATERIALS AND METHODS An individual patient-level data meta-analysis was performed using five data sets on 828 evaluable women who were tested for g BRCA. Of those, 250 carried g BRCA, whereas 578 had tested negative and served as controls. Of the women with g BRCA, four centers studied those affected with breast cancer (n = 161) and one studied unaffected individuals (n = 89). The data were adjusted for the center, age, body mass index, smoking, and oral contraceptive pill us

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Dagogo-Jack, Samuel, Richard E. Pratley, David Z. I. Cherney, et al. "Glycemic efficacy and safety of the SGLT2 inhibitor ertugliflozin in patients with type 2 diabetes and stage 3 chronic kidney disease: an analysis from the VERTIS CV randomized trial." BMJ Open Diabetes Research & Care 9, no. 1 (2021): e002484. http://dx.doi.org/10.1136/bmjdrc-2021-002484.

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IntroductionHere we report the glycemic efficacy and safety of ertugliflozin in patients in the VERTIS CV cardiovascular outcome trial with chronic kidney disease (CKD) stage 3.Research design and methodsPrespecified and post-hoc analyses were performed in patients with an estimated glomerular filtration rate (eGFR) 30–<60 mL/min/1.73 m2 at screening. The primary endpoint was glycemic efficacy at week 18. Longer term glycemic efficacy and changes in body weight, systolic blood pressure (SBP), and eGFR were also evaluated.ResultsAmong 8246 patients in VERTIS CV, 1776 patients had CKD stage 3

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Demark-Wahnefried, Wendy, Robert A. Oster, Kerry P. Smith, et al. "Vegetable Gardening and Health Outcomes in Older Cancer Survivors." JAMA Network Open 7, no. 6 (2024): e2417122. http://dx.doi.org/10.1001/jamanetworkopen.2024.17122.

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ImportanceCancer survivors experience accelerated functional decline that threatens independence and quality of life. Previous studies have suggested that vegetable gardening may improve diet, physical activity, and physical function in this vulnerable population, which comprises more than 5% of the US population.ObjectiveTo assess whether diet, physical activity and functioning, and other outcomes improved in older cancer survivors assigned to a vegetable gardening intervention compared with a waitlist.Design, Setting, and ParticipantsFrom May 11, 2016, to May 2, 2022, a 2-arm, assessor-blind

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Freyer, G., M. Debled, J. F. Geay, et al. "Celecoxib (Ce) + exemestane (Ex) versus placebo + Ex in post-menopausal (PM) metastatic breast cancer (MBC) patients (pts): A double-blind phase III GINECO study." Journal of Clinical Oncology 24, no. 18_suppl (2006): 565. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.565.

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565 Background: in vitro and in vivo studies suggest that COX-2 inhibitors have proper antitumor effect and could enhance the activity of aromatase inhibitors (AI). Methods: PM first-line MBC pts without previous adjuvant AI were randomized to receive per os until progression either A: Ce (400 mg bid) + Ex (25mg/d) or B: placebo (1 tablet bid) + Ex (25mg/d). PFS was the main end-point. The trial was prematurely stopped (Dec 2004) with 157/342 pts enrolled (A: 74, B: 83 pts) after occurrence of Ce cardio-vascular toxicity in other trials. Results: patient (median age, A:61, B:63 yrs) characteri

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Kim, Kenneth T., Niels G. Borgstein, Yijun Yang, et al. "ACE-011, a Soluble Activin Receptor Type IIa IgG-Fc Fusion Protein, Increases Hemoglobin and Hematocrit Levels in Postmenopausal Healthy Women." Blood 112, no. 11 (2008): 3866. http://dx.doi.org/10.1182/blood.v112.11.3866.3866.

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Abstract ACE-011 is a soluble fusion protein consisting of the extracellular domain of activin receptor IIA linked to the Fc portion of human IgG1 and is a potent activin antagonist. ACE-011 is currently in clinical development for the treatment of bone loss in a variety of disease indications. In addition to its effect on bone forming cells, activin is also known as erythroid differentiation factor (EDF) and has been reported to have proerythrocytic effects and induced terminal differentiation of red blood cells (RBC). In preclinical studies, ACE-011 administration to mice and cynomolgus monk

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Galdeano Lozano, Marina, Julio César Alfaro Álvarez, Núria Parra Macías, et al. "Effectiveness of Intermediate Respiratory Care Units as an Alternative to Intensive Care Units during the COVID-19 Pandemic in Catalonia." International Journal of Environmental Research and Public Health 19, no. 10 (2022): 6034. http://dx.doi.org/10.3390/ijerph19106034.

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Objectives: During the COVID-19 pandemic, the risk of collapse for the health system created great difficulties. We will demonstrate that intermediate respiratory care units (IRCU) provide adequate management of patients with non-invasive respiratory support, which is particularly important for patients with SARS-CoV-2 pneumonia. Methods: A prospective observational study of patients with COVID-19 admitted to the ICU of a tertiary hospital. Sociodemographic data, comorbidities, pharmacological, respiratory support, laboratory and blood gas variables were collected. The overall cost of the unit

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Tshalibe, R. S., J. P. Rheeder, J. F. Alberts, et al. "Multi-mycotoxin exposure of children (0-24 months) in rural maize-subsistence farming areas of the Eastern Cape Province, South Africa." World Mycotoxin Journal 13, no. 3 (2020): 401–10. http://dx.doi.org/10.3920/wmj2019.2439.

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In South Africa, child malnutrition is highly prevalent among children from in rural areas mostly at risk. In the Eastern Cape (EC) Province, maize is commonly used as complementary and weaning food. Previous studies conducted in parts of EC have indicated high levels of fumonisin B (FB) mycotoxins in home-grown maize, as well as the co-occurrence of other Fusarium mycotoxins, such as deoxynivalenol (DON) and zearalenone (ZEN). A cross-sectional study of children below 24 months was conducted in rural maize-subsistence farming areas in Centane, EC to determine mycotoxin exposure. Home-grown ma

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Thorey, V., A. Guillot, K. El Kanbi, M. Harris, and P. J. Arnal. "1211 Assessing the Accuracy of a Dry-EEG Headband for Measuring Brain Activity, Heart Rate, Breathing and Automatic Sleep Staging." Sleep 43, Supplement_1 (2020): A463. http://dx.doi.org/10.1093/sleep/zsaa056.1205.

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Abstract Introduction The development of new sleep study devices, adapted for daily use, is necessary for diagnosis of sleep disorders. However, this requires to be both suitable for daily use and capable of recording accurate electrophysiological data. This study assesses the signal acquisition of a comfortable sleep headband, using dry electrodes, and the performance of its automatic sleep staging algorithms compared to the gold-standard clinical PSG scored by 4 sleep experts. Methods 42 participants slept at a sleep center wearing both the Dreem headband (DH) and a PSG simultaneously. We me

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Aringer, M., L. Arnaud, C. Peschken, et al. "POS0731 ASSOCIATION OF PATIENT-REPORTED OUTCOMES WITH TYPE I INTERFERON GENE SIGNATURE FROM THE INTERNATIONAL SYSTEMIC LUPUS ERYTHEMATOSUS PROSPECTIVE OBSERVATIONAL COHORT STUDY (SPOCS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 648–49. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1181.

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BackgroundThe aim of the Systemic Lupus Erythematosus Prospective Observational Cohort Study (SPOCS) is to examine the disease course of patients with systemic lupus erythematosus (SLE) in relation to their type I interferon gene signature (IFNGS) status.1 IFNGS has been associated with SLE disease activity.2ObjectivesTo identify associations between IFNGS status and patient-reported outcomes (PROs) among patients receiving clinical care while enrolled in SPOCS.MethodsThis noninterventional, international, prospective, observational cohort study included adult patients (≥18 years) with moderat

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Zureigat, Hadil, Ahmed N. Mohamed, Muaz Alsabbagh Alchirazi, et al. "Cardiovascular Profile of Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia: A 16-Year Observational Study." Blood 144, Supplement 1 (2024): 1777. https://doi.org/10.1182/blood-2024-212146.

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Background: Chronic myelogenous leukemia (CML) is caused by a chromosomal translocation that gives rise to a chimeric BCR-ABL protein with constitutive tyrosine kinase (TK) activity. Tyrosine kinase inhibitors (TKIs) block this protein and have thus led to a paradigm shift in CML management in the early 2000s. Despite TKIs' efficacy in CML, their cardiotoxic side effects are a clinical challenge. This may result in TKI discontinuation and ultimately suboptimal response. Hence, we aim to explore the cardiotoxicity profile of TKIs, adjusting for pre-existing cardiovascular risk factors. Methods:

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Chan, Vincent, C. David Mazer, Faeez Mohamad Ali, et al. "Randomized, Controlled Trial Comparing Mitral Valve Repair With Leaflet Resection Versus Leaflet Preservation on Functional Mitral Stenosis." Circulation 142, no. 14 (2020): 1342–50. http://dx.doi.org/10.1161/circulationaha.120.046853.

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Background: Equipoise exists between the use of leaflet resection and preservation for surgical repair of mitral regurgitation caused by prolapse. We therefore performed a randomized, controlled trial comparing these 2 techniques, particularly in regard to functional mitral stenosis. Methods: One hundred four patients with degenerative mitral regurgitation surgically amenable to either leaflet resection or preservation were randomized at 7 specialized cardiac surgical centers. Exclusion criteria included anterior leaflet or commissural prolapse, as well as a mixed cause for mitral valve diseas

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Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Luchristt, Douglas, C. Emi Bretschneider, Kimberly Kenton, Melissa Simon, and Oluwateniola Brown. "Inequities in Filled Overactive Bladder Medication Prescriptions in the US." JAMA Network Open 6, no. 5 (2023): e2315074. http://dx.doi.org/10.1001/jamanetworkopen.2023.15074.

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ImportanceAnticholinergic medications to treat overactive bladder (OAB) have been associated with increased risk of cognitive decline, whereas β3-adrenoceptor agonists (hereafter, β3-agonists) have comparable efficacy and do not carry the same risk. Yet, anticholinergics remain the predominant OAB medication prescribed in the US.ObjectiveTo evaluate whether patient race, ethnicity, and sociodemographic characteristics are associated with receipt of anticholinergic vs β3-agonist OAB medications.Design, Setting, and ParticipantsThis study is a cross-sectional analysis of the 2019 Medical Expendi

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Schürch, Yannik, Manuel Burger, Lauren Amor, et al. "Comparison of an exergame and a moderate-intensity endurance training intervention on physiological parameters." Current Issues in Sport Science (CISS) 8, no. 2 (2023): 071. http://dx.doi.org/10.36950/2023.2ciss071.

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Background Exergames are interactive video games that stimulate an active, whole-body gaming experience (Best, 2013). By combining electronic entertainment with physical exercise, exergames offer novel opportunities to expand physical activity in different age groups and settings. Even though studies have found a significant increase in energy expenditure when playing exergames compared to normal video games, most games only induce low to moderate-intensity activity which is too low to result in relevant physical adjustments (Biddiss & Irwin, 2010). This study assessed the effects of

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Khanna, D., C. J. F. Lin, H. Spotswood, J. Siegel, D. Furst, and C. Denton. "THU0328 SAFETY AND EFFICACY OF SUBCUTANEOUS TOCILIZUMAB IN SYSTEMIC SCLEROSIS: RESULTS FROM THE OPEN-LABEL PERIOD OF THE PHASE 3 FOCUSSCED TRIAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 394.1–394. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1535.

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Background:The anti–interleukin-6 (IL-6) receptor-α antibody tocilizumab (TCZ) demonstrated skin score improvement and forced vital capacity (FVC) preservation in patients with systemic sclerosis (SSc) in a phase 2 randomized controlled trial.1,2Data from the 48-week, double-blind (DB), placebo (PBO)-controlled period of the focuSSced phase 3 trial were previously presented,3and open-label (OL) data up to week 96 are presented herein.Objectives:To assess the long-term safety and efficacy of TCZ in SSc patients.Methods:Adult patients with active SSc (≤60-month duration, modified Rodnan skin sco

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Mantilla, M. J., G. Rodríguez Salas, A. M. Santos, et al. "AB1069 GENDER DIFFERENCES IN PRESENTATION, CLASSIFICATION, AND DISEASE ACTIVITY OF SPONDYLOARTHRITIS: RESULTS FROM GESPA COLOMBIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1755.3–1756. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3922.

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BackgroundSpondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder composed of axial (AxSpA) and peripheral (pSpA) disease. AxSpA is further subdivided into radiographic AxSpA (r-AxSpA) and non-radiographic AxSpA (r-AxSpA). Historically, SpA was mostly a male disease. However, actual disease awareness has changed the approach, allowing women to be included to a greater extent.ObjectivesFew studies have explored the male and female disease features in Latin American population. The aim of this study was to examine the clinical presentation, disease onset characteristics, metrology,

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Kahraman, Doğan, Gökhan Keskin, Emced Khalil, and Omer Faruk Dogan. "Ten-Year Clinical Experience on Chylothorax after Cardiovascular Surgery." Heart Surgery Forum 23, no. 1 (2020): E081—E087. http://dx.doi.org/10.1532/hsf.2655.

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Background: Chylothorax or pseudo-chylothorax is a serious complication after adult and pediatric cardiac surgery. This study presents our 10-year clinical experience of chylothorax after cardiac surgery. Methods: Between January 2008 and February 2019, 4896 cardiovascular surgeries were performed in 2 tertiary clinics, with 416 patients in the pediatric age group (8.4%). Chylothorax and pseudo-chylothorax were detected in 47 patients (22 adult and 20 pediatric patients, 4.8%). Pseudo-chylothorax was seen in 5 adult patients. In 27 patients, a pleural effusion developed on the left side

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Gamboa-Alonso, C. M., M. J. Garza Martínez, B. R. Vázquez Fuentes, et al. "SAT0206 MINOR SALIVARY GLAND BIOPSY AND SEROLOGICAL PROFILE IN PRIMARY SJÖGREN’S SYNDROME: A SINGLE TERTIARY REFERRAL CENTER EXPERIENCE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1046.2–1046. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6278.

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Background:Minor salivary gland biopsy (MSGB) portrays an important role as part of the diagnostic criteria of primary Sjögren’s syndrome (pSS) in the ACR/EULAR 2016 classification. Autoantibodies anti-Ro/SSA and anti-La/SSB embody part of these criteria. Patients with negative serology have been classified as pSS using MSGB outcomes in up to 40% of cases.Objectives:Compare MSGB and serological characteristics between pSS positive biopsy versus pSS negative biopsy and sicca groups.Methods:174 subjects with sicca symptoms and MSGB biopsy were studied. Patients who fulfilled the ACR/EULAR 2016 c

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Hashiyada, Y., H. Takahashi, D. Yamaguchi, K. Imai та M. Geshi. "74 EFFECT OF SIZE AND CULTURE PERIOD OF FROZEN–THAWED BOVINE TROPHOBLASTIC VESICLES ON INTERFERON-τ SECRETION". Reproduction, Fertility and Development 26, № 1 (2014): 151. http://dx.doi.org/10.1071/rdv26n1ab74.

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Frozen–thawed bovine trophoblastic vesicles (bTV) derived in vivo could secrete interferon-τ (IFN-τ) at the same level as fresh bTV on Days 4 to 6 after thawing. However, amounts of IFN-τ decreased following continuous in vitro culture (Hashiyada et al. 2012 38th IETS). Co-transfer of frozen–thawed bTV improved pregnancy rate of embryos due to the effects of IFN-τ secreted by bTV (Hashiyada et al. 2008 41th SSR). However, the relation between bTV size and IFN-τ secretion level during culture has not been well documented. The objective of present study was to characterise the concentration of I

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Suttorp, Meinolf, Ralf Knoefler, Hélène Deutsch, et al. "High Platelet Counts, Thrombosis, Bleeding Signs, and Acquired Von Willebrand Syndrome at Diagnosis of Pediatric Chronic Myeloid Leukemia." Blood 134, Supplement_1 (2019): 4152. http://dx.doi.org/10.1182/blood-2019-123343.

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Background: At diagnosis of chronic myeloid leukemia (CML) patients (pats) may present with elevated platelets (PLT) counts. Generally, high PLT counts may result in thrombosis and/or bleeding complications, the latter being due to binding of von Willebrand factor (VWF) multimers to platelets. Pediatric CML is very rare (Hijiya N, Suttorp M 2019; Blood 33:2374-2384) and no systematic investigation on clinical complications of elevated PLT counts has so far been reported. Methods: Data on PLT counts and associated thrombo-hemorrhagic complications were retrospectively analyzed in newly diagnose

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Morlà, R., T. LI, G. Luta, and T. Pincus. "AB0786 Self-reported disease burden is greater in spondyloarthritis than in rheumatoid arthritis patients according to multidimensional questionnaire (MDHAQ / RAPID3) scores, despite fewer females, who generally have higher scores on patient questionnaires." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1520.1–1520. http://dx.doi.org/10.1136/annrheumdis-2022-eular.852.

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BackgroundFemale patients generally have higher scores than males on most items on self-report questionnaires, including MDHAQ/RAPID3 (multi-dimensional health assessment questionnaire/routine assessment of patient index data)1. MDHAQ/RAPID3 was validated in patients with rheumatoid arthritis (RA), but is informative in all diseases studied, including spondyloarthritis (SpA)2. More SpA patients are men than RA patients, suggesting lower scores, but MDHAQ scores are higher in SpA than RA.ObjectivesWe compared self-report MDHAQ/RAPID3 scores in RA vs SpA patients according to gender.MethodsPatie

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