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Journal articles on the topic '342.56 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Bowmaker, Graham A., Jack M. Harrowfield, Peter C. Junk, Brian W. Skelton, and Allan H. White. "Syntheses, Structures and Vibrational Spectra of Some Dimethyl Sulfoxide Solvates of Bismuth(III) Bromide and Iodide." Australian Journal of Chemistry 51, no. 4 (1998): 285. http://dx.doi.org/10.1071/c97035.

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Room-temperature single-crystal X-ray studies are recorded for some dimethyl sulfoxide (dmso) solvates of bismuth(III) bromide and iodide. Colourless BiBr3.3dmso is triclinic, P-1, a 8·467(4), b 9·109(4), c 13·901(4) Å, α 76·34(4), β 76·95(4), γ 64·56(4)°, Z = 2; conventional R on |F| was 0·050 for No 2306 independent ‘observed’ (I > 3σ(I)) reflections. The complex is mononuclear with a quasi-octahedral fac-bismuth environment, [(dmso-O)3BiBr3], isomorphous with the previously determined chloride. Orange BiI3-2dmso is triclinic, P-1, a 12·558(2), b 8·962(2), c 8·342(1) Å, α 61·85(1), β 78·2

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Fontaine, C., M. Huizing, A. Dewaele, et al. "Overnight fasting serum cholesterol, HDL, LDL and triglycerides levels and bone mineral density (BMD) values during adjuvant letrozole in daily practice." Journal of Clinical Oncology 25, no. 18_suppl (2007): 11040. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.11040.

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11040 Background: Background: Randomized clinical trials (RCT’s) have demonstrated a superiority of adjuvant aromatase inhibitors (AI’s) over tamoxifen (TAM) in disease free survival and overall survival, immediately postoperatively, in cross-over or extended setting in hormone receptor positive BC. In these studies AI’s were associated with increased bone demineralization and a rise in non- fasting serum cholesterol. Patients and methods: The tolerance for adjuvant letrozole was reviewed in 185 postmenopausal women with hormone receptor-positive early BC including fasting cholesterol levels a

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Fedyanin, Mikhail, Alexey Tryakin, Alla Sergeevna Lisyanskaya, et al. "Results of a completed first-in-human phase Ib dose-escalation study of oral CBL0137 in patients with advanced solid tumors." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3607. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3607.

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3607 Background: Curaxin CBL0137 is a novel compound with broad anticancer activity in animal models. The drug is a non-genotoxic DNA intercalator that interferes with histone/DNA binding causing decondensation of chromatin in tumor cells, functional inactivation of histone chaperone FACT, activation of p53 and IFN responses, and inhibition of pro-cancer transcriptional factors, MYC, NF-kB, HSF1, and HIF1a. Methods: The study enrolled adults with advanced chemorefractory solid tumors, ECOG PS ≤2, and adequate organ function. The primary objective was to find the maximum tolerated dose (MTD) an

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Herrero-Morant, A., J. Loricera, I. Ferraz-Amaro, et al. "AB0707 PREDICTIVE FACTORS OF RELAPSE IN GIANT CELL ARTERITIS TREATED WITH TOCILIZUMAB." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1557.2–1558. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4399.

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BackgroundTocilizumab (TCZ) is the only biologic therapy approved for giant cell arteritis (GCA). Clinical trials with TCZ in GCA was performed with intravenous (iv) TCZ in a phase 2 trial[1], and with subcutaneous (sc) TCZ in the phase 3 GiACTA[2].There is general agreement on the initial/maintenance dose, but duration of TCZ therapy is not well established. In GiACTA trial, after one year on TCZ, most patients had GCA relapse after withdrawal.ObjectivesTo assess the predictive factors of relapse in GCA in a clinical practice scenario.MethodsMulticentre observational study of 471 patients wit

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Szabó, A., J. Nagy, J. Bokor, et al. "Clinical chemistry of farmed red deer (<i>Cervus elaphus</i>) yearling hinds reared on grass or <i>papillonaceous</i> pasture paddocks in Hungary." Archives Animal Breeding 56, no. 1 (2013): 443–54. http://dx.doi.org/10.7482/0003-9438-56-043.

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Abstract. Yearling red deer (Cervus elaphus) hinds of identical initial body weight were reared on a monocotyledonous grass (group 1) or on a papillonaceous plant pasture (group 2) for 212 days. At the end of the experiment (when deer were shot) blood was taken from ten animals of each group for serum biochemical analysis. Hinds of group 2 provided higher final body weight (90±3.5 vs. 101±6.6 kg) and higher daily body weight gain (105.7±10.7 vs. 153.8±26.8 g/day). Within serum nitrogenous compounds group 2 provided higher total protein concentrations, while from the lipids only serum triglycer

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Yoneyama, Takahiro, Yuki Tobisawa, Tohru Yoneyama, et al. "Carboplatin-based sequential chemotherapy for aged patients with advanced bladder cancer." Journal of Clinical Oncology 33, no. 7_suppl (2015): 342. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.342.

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342 Background: We retrospectively evaluated the feasibility and effectiveness of carboplatin based chemotherapy for the patients 65 years or older with advanced bladder cancer. Methods: We treated 86 patients with advanced bladder cancer at our clinic between August 2004 and June 2014. 56 patients (40 men and 16 women) with the age of 65 years or older were enrolled. Their average age was 75.8 years old (65–86), average Ccr was 54.4 ml/min (14.5–113.0), and an average follow-up period was 21.7 months (2–81). There were 18 recurrent cases after radical surgery and 38 inoperable cases. The ther

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Sharma, Sumeet. "Knowledge and attitude towards orthodontic treatment among adolescent patients visiting a private dental clinic in Udaipur City, Rajasthan: a cross-sectional descriptive study." Journal of Research in Dentistry 5, no. 3 (2018): 51. http://dx.doi.org/10.19177/jrd.v5e3201751-56.

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Aim: Present study is conducted to put some light on the knowledge and attitude of adolescents coming to private dental clinicMaterial and Methods: The present study was conducted on adolescent subjects visiting a private dental clinic for various reasons. The study was conducted in May- June 2017. In these 2 months out of total patients a total of 342 adolescents had visited to the clinic. Out of which 293 adolescents had given there informed consent were included in the study. A structured close ended questionnaire was prepared to check the Knowledge and attitude of the study participants.Re

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Chang, Yifan, Yue Xuan, Ruinan Zhang та ін. "Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents". Animals 15, № 1 (2024): 21. https://doi.org/10.3390/ani15010021.

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The objective of this experiment is to investigate the effects of SAP or SAO as ω-3 PUFA raw materials on production performance, egg quality, serum immunity, serum lipids, and fatty acid deposition patterns in the eggs of laying quails. Chinese yellow-feathered quails served as the experimental subjects. A single-factor design was employed to randomly assign 1288 quails into four treatment groups, with seven replicates per treatment and 46 birds in each replicate. The groups included a control group (basal diet with no SAP), 1.6% SAP, 3.2% SAP, and 0.8% SAP + 0.3% SAO. The results indicate th

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Zammit, Gary, David Mayleben, Ingo Fietze, et al. "344 Daridorexant Improves Total Sleep Time (TST) in Insomnia Patients Without Altering the Proportion of Sleep Stages." Sleep 44, Supplement_2 (2021): A137—A138. http://dx.doi.org/10.1093/sleep/zsab072.343.

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Abstract Introduction Daridorexant, a new dual orexin receptor antagonist, improved sleep parameters and daytime functioning in two pivotal Phase 3 trials in patients with insomnia (Trial-1, NCT03545191; Trial-2, NCT03575104); polysomnography data were collected at multiple timepoints from &gt;1,800 patients. We report the effects of daridorexant on TST and sleep stages from both trials. Methods Eligible patients with insomnia (according to DSM-5) were randomized (1:1:1) in Trial-1 (N=930) to daridorexant 25mg, 50mg, or placebo and in Trial-2 (N=924) to daridorexant 10mg, 25mg, or placebo.

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Mazari, Muhammad Ejaz, Fazal ur Rehman, and Muhammad Ashfaq Zafar. "Hypoglycemia in Newborns with risk factors of hypoglycemia." Professional Medical Journal 27, no. 01 (2020): 84–88. http://dx.doi.org/10.29309/tpmj/2019.27.01.3333.

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Objectives: Hypoglycemia is a matter of great concern especially in newborns. Its prevalence varies globally as different protocols and feeding policies exist. We aimed this study to find out the incidence of hypoglycemia in newborns with risk factors of hypoglycemia. Study Design: Observational study Setting: Pediatric Medicine Unit-2, Mayo Hospital, Lahore. Period: From 1st January 2018 to 31st December 2018. Material & Methods: A total of 342 babies born with risk factors for hypoglycemia fulfilling the inclusion and exclusion criteria were considered for this study. Screening for hypog

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Wiryawan, Drajad, Joni Suhartono, Siti Elda Hiererra, and Anderes Gui. "Factors Affecting Digital Banking Customer Satisfaction in Indonesia." International Journal of Application on Sciences, Technology and Engineering 1, no. 1 (2023): 335–42. http://dx.doi.org/10.24912/ijaste.v1.i1.335-342.

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This paper aims to determine the factors that influence the satisfaction of using digital banking. The method used is UTAUT (Model Unified Theory of Acceptance and Use of Technology) 2 Modification to help specify variables such as Responsiveness, Usefulness, Ease of Use, History, Access Control, Data Privacy, Assurance, etc. Trust, Quality Transaction, User Intention, and User Satisfaction. This research collects data in a questionnaire distributed to digital banking users through a non-probability sampling method using a data collection technique, namely, snowball sampling. For information,

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Paduvakis, I., A. Cerillo, F. Petrini, and A. Manca. "P294 BIOPROSTHETIC AORTIC VALVE REPLACEMENT IN PATIENTS AT INCREASED RISK OF EARLY STRUCTURAL VALVE DEGENERATION." European Heart Journal Supplements 25, Supplement_D (2023): D155. http://dx.doi.org/10.1093/eurheartjsupp/suad111.368.

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Abstract Background Biological prostheses are increasingly been used in young patients to avoid anticoagulation. The Edwards Inspiris aortic bioprosthesis is extremely promising in this population, since it has shown reduced calcification of the prosthetic leaflets in preclinical and early clinical studies. Little data are available, however, in patients younger than 65. This study investigates the hemodynamic performance and clinical outcome of the Inspiris bioprosthesis in patients aged 56 ± 10.7 years. Methods and Results Between may 2018 and December 2022, 342 patients aged 56 ± 10.7 years

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Tiur Ida. "PENINGKATAN PRESTASI BELAJAR PKn DENGAN MODEL COOPERATIVE LEARNING MENGGUNAKAN MEDIA STIK BERJALAN PADA SISWA KELAS III SD NEGERI 023 KASIKAN KECAMATAN TAPUNG HULU TAHUN 2021." EduTeach : Jurnal Edukasi dan Teknologi Pembelajaran 3, no. 1 (2022): 41–50. http://dx.doi.org/10.37859/eduteach.v3i1.3411.

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Permasalahan dalam penelitian ini adalah bagaimana cara meningkatkan prestasi belajar Pendidikan Kewarganegaraan (PKn) dengan model Cooperative Learning menggunakan media stik berjalan pada siswa kelas III SD 023 Kasikan . Tujuan penelitian ini adalah (1) Meningkatkan aktivitas siswa, (2) Meningkatkan aktivitas guru, (3) Meningkatkan prestasi belajar siswa melalui model pembelajaran Cooperative Learning dengan media stik berjalan . Penelitian ini adalah penelitian tindakan kelas yang dilakukan dengan 2 siklus. Setiap siklus terdiri dari empat tahapan, yaitu: (1) perencanaan, (2) pe

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Scott, Aaron James, Bert H. O'Neil, Christina Gomes, et al. "A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer." Journal of Clinical Oncology 33, no. 3_suppl (2015): 342. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.342.

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342 Background: Rigosertib (ON 01910.Na), a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase (PI3K) pathways, was assessed in patients with treatment-naïve metastatic pancreatic adenocarcinoma. Methods: Patients with metastatic adenocarcinoma of the pancreas were randomized in a 2:1 fashion to gemcitabine 1000 mg/m2 weekly for 3 weeks of a 4-week cycle plus rigosertib 1800mg/m2 via 2-hr CIV infusions given twice weekly for 3 weeks of a 4-week cycle versus gemcitabine 1000mg/m2 weekly for 3 weeks in a 4-week cycle. Results: A total of 160 patients were enrolled

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VYALKOV, V. G., S. N. GLAZUNOV, and P. A. TSIRKOV. "RESTORATION OF WORN SURFACES FROM CAST IRON AND STEEL PARTS BY ELECTRIC ARC WELDING WITH FERROMAGNETIC CHARGE." Fundamental and Applied Problems of Engineering and Technology 4, no. 2 (2020): 112–16. http://dx.doi.org/10.33979/2073-7408-2020-342-4-2-112-116.

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In experiment, worked out the parameters of deposition and the composition of the ferromagnetic charge, which ensure a defect-free weld layer (no pores, inclusions, hot and cold cracks) with a surface hardness of 52- 56 HRC without additional technological measures (heating products) and subsequent heat treatment.

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SCHMIDT, JOHN W., AMIT VIKRAM, ERIC MILLER, SHUNA A. JONES, and TERRANCE M. ARTHUR. "In-Feed Tylosin Phosphate Administration to Feedlot Cattle Minimally Affects Antimicrobial Resistance." Journal of Food Protection 83, no. 2 (2020): 350–64. http://dx.doi.org/10.4315/0362-028x.jfp-19-342.

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ABSTRACT The macrolide class antimicrobial tylosin (trade name Tylan) is approved by the U.S. Food and Drug Administration for continuous inclusion in feed for liver abscess prevention. To address concerns that this antimicrobial application may threaten human health, a population of feedlot steers was split into a control treatment (n = 42) and a tylosin treatment (n = 42). Feed rations were identical except for the inclusion of tylosin at 60 to 90 mg per head per day. Fecal swab (n = 335), pen surface material (n = 256), feed (n = 56), and water trough (n = 32) samples were obtained over fou

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Lee, Chien-Feng, Yunn-Jy Chen, Yu-Ching Chen, Pei-Lin Lee, and Chong-Jen Yu. "0473 Multi-outcome of mandibular advancement device in Obstructive Sleep Apnea with different polysomnographic phenotype." SLEEP 46, Supplement_1 (2023): A210. http://dx.doi.org/10.1093/sleep/zsad077.0473.

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Abstract Introduction The association of mandibular advancement device (MAD) treatment response and polysomnographic phenotype in patients with obstructive sleep apnea (OSA) has not been fully elucidated. We hypothesized MAD response would be associated with two polysomnographic phenotypes, including sleep stage and positional dependency in treatment-naïve patients with moderate-severe obstructive OSA. Methods This retrospective study recruited OSA patients with AHI ≥15/h, aged 20 to 80, treatment naïve, and received MAD treatment for more than three months. Positional phenotype included supi

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Shin, Jeongae. "Development and Validation of Empathy scale for Early Childhood Teachers." Korean Association For Learner-Centered Curriculum And Instruction 23, no. 6 (2023): 59–71. http://dx.doi.org/10.22251/jlcci.2023.23.6.59.

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Objectives The purpose of this study is to develop and validate a empathy scale for early childhood teachers. Methods To this end, 128 preliminary questions were developed through literature review. Next, the opinions of 5 experts were collected through content validity verification, and 56 items were extracted through validity testing. Afterwards, a preliminary survey was conducted on 20 teachers, and a main survey was conducted on 342 teachers. After exploratory factor analysis and confirmatory factor analysis were conducted, the validity and reliability were finally verified. Results Based

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Tereshchenko, Tatyana S. "IMAGES OF PERSIANS IN THE ART OF ANCIENT GREECE: ISSUES OF DIFFERENTIATION AND TRANSFORMATION." Journal of historical philological and cultural studies 2, no. 56 (2017): 307–22. http://dx.doi.org/10.18503/1992-0431-2017-2-56-307-322.

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Edwards, S. A., A. W. Armsby, and H. H. Spechter. "Effects of floor area allowance on performance of growing pigs kept on fully slatted floors." Animal Production 46, no. 3 (1988): 453–59. http://dx.doi.org/10.1017/s0003356100019061.

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ABSTRACTThe experiment compared four different space allowances for growing pigs housed on fully slatted floors. Space allowance (A m2) was defined in relation to live weight (M kg) of the pigs according to the equation A = kM0·67, using values for the constant (it) of 0·024, 0·027, 0·030 and 0·034. Six replicate pens of 12 pigs were housed on each treatment in a controlled environment building. Food was given ad libitum and from 34 kg until slaughter at 85 kg pigs were individually weighed each week and the pen size was adjusted according to the appropriate equation. Increasing space allowanc

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Chang, Young D., Jae-Woo Jung, Ritika Oberoi-Jassal, et al. "Edmonton Symptom Assessment Scale and Clinical Characteristics Associated With Cannabinoid Use in Oncology Supportive Care Outpatients." Journal of the National Comprehensive Cancer Network 17, no. 9 (2019): 1059–64. http://dx.doi.org/10.6004/jnccn.2019.7301.

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Background: Information about the frequency of cannabinoid use and the clinical characteristics of its users in oncology supportive care is limited. This study explored associations between cannabinoid use and cancer-related clinical characteristics in a cancer population. Patients and Methods: This retrospective review included 332 patients who had a urine drug test (UDT) for tetrahydrocannabinol (THC) together with completion of an Edmonton Symptom Assessment Scale (ESAS) and cannabinoid history questionnaire on the same day that urine was obtained during 1 year in the supportive care clinic

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Suntharalingam, Mohan, Kathryn Winter, David H. Ilson, et al. "The initial report of RTOG 0436: A phase III trial evaluating the addition of cetuximab to paclitaxel, cisplatin, and radiation for patients with esophageal cancer treated without surgery." Journal of Clinical Oncology 32, no. 3_suppl (2014): LBA6. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.lba6.

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LBA6 Background: RTOG 0436 is a randomized Ph III trial designed to evaluate the benefit of cetuximab added to the concurrent chemoradiation for patients undergoing non-operative management of esophageal carcinoma. Methods: Pts with biopsy-proven squamous cell or adenocarcinoma of the esophagus (T1N1M0; T2-4 AnyN M0; Any T/N M1a) were randomized to weekly concurrent cisplatin (50 mg/m2), paclitaxel (25 mg/m2), and daily radiation 50.4 Gy/1.8 Gy fractions ± weekly cetuximab (400 mg/m2 day 1 then weekly 250 mg/m2). Patients were stratified by histology, tumor size (< 5 cm vs > 5cm), and th

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Harlin, Matthew, Murat Yildirim, Pedro Such, Jessica Madera-McDonough, and Frank Larsen. "Pharmacokinetic Profile of Aripiprazole 2-Month Ready-to-Use 960 mg in Adult Patients With Schizophrenia or Bipolar I Disorder." CNS Spectrums 28, no. 2 (2023): 256. http://dx.doi.org/10.1017/s1092852923002006.

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AbstractIntroductionAripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a new long-acting injectable (LAI) antipsychotic formulation for gluteal administration every 2 months, intended for the treatment of schizophrenia and maintenance monotherapy treatment of bipolar I disorder (BP-I). This 32-week trial evaluated the safety, tolerability, and pharmacokinetic profile of multiple-dose administration of Ari 2MRTU 960 in clinically stable adult patients with a diagnosis of schizophrenia or BP-I, versus that of aripiprazole once-monthly 400 mg (AOM 400; an LAI indicated for the treatment

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Imai, Toru, Hidekazu Hirano, Hirokazu Shoji, et al. "A retrospective analysis of the efficacy and safety of capecitabine plus oxaliplatin (CapeOX) and docetaxel plus S-1 (DS) as adjuvant chemotherapy for pathological stage III (p stage III) gastric cancer (GC)." Journal of Clinical Oncology 42, no. 3_suppl (2024): 342. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.342.

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342 Background: Adjuvant chemotherapy following surgical resection is the standard treatment for patients with p stage III GC in Japan. Although CapeOX and DS are available for adjuvant chemotherapy for stage III GC, there is limited data on which treatment is more effective. We aim to compare the efficacy and safety of CapeOX and DS as adjuvant chemotherapy in patients with p stage III GC. Methods: We extracted data of patients with p stage III GC who received either CapeOX (capecitabine on days 1–14 plus oxaliplatin on day1 for 8 cycles [q 3week]) or DS (S-1 on days 1–14 at 1st cycle [q 3 we

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Fjellstad, C. P., M. Hägg, M. Kautonen, and R. Mandla. "POS0060-PARE RHEUMATOID ARTHRITIS IN NORWAY: A SURVEY-BASED PATIENT EXPERIENCE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 236. http://dx.doi.org/10.1136/annrheumdis-2021-eular.966.

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Background:The Norwegian Association of Rheumatologists has established a national procedure for management of rheumatoid arthritis (RA) in Norway.1 The purpose of the procedure is to support equal and evidence-based diagnosis, care and follow-up of RA patients1. It serves as guidance to all responsible of RA patient health care. The procedure includes recognized themes in rheumatic care.2,3 The impact of the procedure on RA care in Norway is, however, unknown.Objectives:To understand the patient experience through evaluating how the national procedure for RA is being followed from the patient

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Ullah, Md Sofi. "Geospatial Modeling of Landslide Vulnerability and Simulating Spatial Correlation with Associated Factors in Bandarban District." Dhaka University Journal of Earth and Environmental Sciences 8, no. 2 (2021): 51–66. http://dx.doi.org/10.3329/dujees.v8i2.54839.

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The present study aims at identifying and predicting landslide vulnerable areas in Bandarban District of Chittagong Hill Tracts (CHT) using weighted overlaying of the multiple geospatial layers to determine landslide hazard areas. The historical landslide inventory map was prepared using Google Earth image and through PRA technique. Then ten landslide triggering factors including landuse, rainfall, slope, elevation, cut-fill, soil types, geology, distance to rivers, roads and stream orders, population density, income, education of the inhabitants were chosen as effective factors on a landslide

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Kuemmerle-Deschner, Jasmin Beate, Raju Gautam, Aneesh Thomas George, Syed Raza, Kathleen Graham Lomax, and Peter Hur. "Systematic literature review of efficacy/effectiveness and safety of current therapies for the treatment of cryopyrin-associated periodic syndrome, hyperimmunoglobulin D syndrome and tumour necrosis factor receptor-associated periodic syndrome." RMD Open 6, no. 2 (2020): e001227. http://dx.doi.org/10.1136/rmdopen-2020-001227.

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ObjectivesSeveral therapies are used for the treatment of rareautoinflammatory conditions like cryopyrin-associated periodic fever syndromes (CAPS), hyperimmunoglobulin Dsyndrome (HIDS)/mevalonate kinase deficiency (MKD) and tumour necrosis factor receptor-associated periodic syndrome (TRAPS). However, reviews reporting on treatment outcomes of these therapies are lacking.MethodsA systematic literature review was conducted using Embase, MEDLINE, MEDLINE-In Process and Cochrane databases to identify the randomised/non-randomised controlled trials (RCTs/non-RCTs) and real-world observational stu

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Benavides-Villanueva, F., R. Fernández-Ramón, J. J. Gaitán-Valdizán, et al. "AB1636 CLINICAL PHENOTYPES IN SARCOIDOSIS USING CLUSTER ANALYSIS IN A COHORT OF 342 PATIENTS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2052–53. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5572.

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BackgroundSarcoidosis is a multi-system disease with unknown etiology characterized by the formation of granulomas in various organs. It affects people of all ethnic backgrounds and occurs at any time of life. This disease can affect any organ with a frequency varying according to ethnicity, sex and age most of the time affecting the pulmonary system with symmetrical bilateral hilar adenopathy. Extrapulmonary manifestations in skin, eyes, liver or lymphatic system can take a great morbimortality in patients.ObjectivesToa) indicate the phenotypes with similar characteristics with a cluster anal

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O'Shaughnessy, Joyce, Francois Clement Bidard, Patrick Neven, et al. "Imlunestrant with or without abemaciclib in advanced breast cancer (ABC): Safety analyses from the phase III EMBER-3 trial." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1060. https://doi.org/10.1200/jco.2025.43.16_suppl.1060.

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1060 Background: Imlunestrant is a next-generation, brain-penetrant, oral SERD. The EMBER-3 trial (NCT04975308) in patients with ER+, HER2- ABC and disease progression on/after aromatase inhibitor therapy showed significant progression-free survival improvement with imlunestrant (imlu; 400 mg once daily [QD]) over standard therapy (SOC, fulvestrant or exemestane) among patients with ESR1 mutations, as well as with imlunestrant+abemaciclib (imlu [400 mg QD] + abema [150 mg twice daily]) over imlu in all patients regardless of ESR1 mutation status. Detailed safety analyses are presented. Methods

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Kozicki, Bartosz. "Multidimensional analysis of population in Poland and Germany between 2024-2050." Nowoczesne Systemy Zarządzania 19, no. 3 (2024): 107–24. https://doi.org/10.37055/nsz/203233.

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Cel badań i hipotezy/pytania badawczeW artykule sformułowano następujący problem badawczy: jak zmieni się populacja emerytów (od 65. roku życia) w roku 2050 w porównaniu do roku 2024 w Polsce i w Niemczech? Celem badań jest próba wykonania wielowymiarowej analizy porównawczej danych dotyczących populacji ludzi w Polsce i w Niemczech między rokiem 2024 a rokiem 2050. W publikacji postawiono następującą hipotezę badawczą: przypuszcza się, że liczba ludzi w grupie od 65+ w 2050 r. w Polsce i w Niemczech wzrośnie w porównaniu do 2024 r. o co najmniej 7 pp.Metody badawczeW opracowaniu zastosowano n

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Ghosh, Joydeep, Sandip Ganguly, Debapriya Mondal, Prashant Pandey, Deepak Dabkara, and Bivas Biswas. "Perspective of Oncology Patients During COVID-19 Pandemic: A Prospective Observational Study From India." JCO Global Oncology, no. 6 (September 2020): 844–51. http://dx.doi.org/10.1200/go.20.00172.

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PURPOSE The coronavirus disease 2019 (COVID-19) pandemic has imposed a unique challenge to oncology patients and their treatment. There is no study related to the patients’ preference for systemic therapy during this pandemic. We have conducted a prospective study to analyze that aspect. METHODS All consecutive patients who visited during the lockdown period from April 1-10, 2020, for systemic chemotherapy were included in the study for a questionnaire-based survey to evaluate the willingness to continue chemotherapy during this pandemic and factors influencing the decisions. RESULTS A total o

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Chang, Yingjun, Yu Wang, Xiao-Dong Mo, et al. "Optimal Dose of Antithymocyte Globulin in Conditioning Regimens for Unmanipulated Haploidentical Haematopoietic Stem Cell Transplantation: Long-Term Outcomes of a Prospective Randomised Trial." Blood 128, no. 22 (2016): 3433. http://dx.doi.org/10.1182/blood.v128.22.3433.3433.

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Abstract Background: Antithymocyte globulin (ATG) is an important component of conditioning regimens to prevent severe GVHD in patients undergoing unmanipulated haploidentical stem cell transplantation (haplo-SCT). However, the optimal dose of ATG is unknown. Methods: In this open-label extension of a prospective, randomised trial, we compared the long-term outcomes of two ATG doses used in myeloablative conditioning before unmanipulated haplo-HSCT. Patients were randomly assigned (1:1) to 10 mg/kg (ATG-10) or 6 mg/kg (ATG-6) ATG. Patients and individuals assessing outcomes were masked to trea

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SCHAFTENAAR, E., N. S. KHOSA, G. S. BAARSMA, et al. "HIV-infected individuals on long-term antiretroviral therapy are at higher risk for ocular disease." Epidemiology and Infection 145, no. 12 (2017): 2520–29. http://dx.doi.org/10.1017/s0950268817000978.

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SUMMARYIntroduction of antiretroviral therapy (ART) has dramatically reduced the incidence of infectious ocular diseases in human immunodeficiency virus (HIV)-infected individuals. However, the effects of long-term ART and chronic HIV infection on the eye are ill-defined. This study determined the occurrence and severity of ocular diseases among 342 participants in a rural South African setting: HIV-naïve (n = 105), HIV-infected ART-naïve (n = 16), HIV-infected on ART for <12 months (short-term ART; n = 56) and HIV-infected individuals on ART for >36 months (long-term ART; n = 165). More

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Lagutina, I., G. Lazzari, and C. Galli. "332 EFFECT OF DIFFERENT PIG OOCYTE ACTIVATION PROTOCOLS ON EMBRYO DEVELOPMENT IN SOF AND NCSU-23." Reproduction, Fertility and Development 19, no. 1 (2007): 281. http://dx.doi.org/10.1071/rdv19n1ab332.

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Several factors affect nuclear transfer success. These include efficient parthenogenetic activation and embryo culture medium that should efficiently support pre-implantation development of good quality blastocysts. We investigated pig oocyte activation and embryo development in SOFaa in response to ionomycin (Io = 5 µM Io for 4 min; Io° = 15 µM Io for 20 min) and electric impulse (EL; one 30-µs pulse of DC 1.5 kV cm−1 in the presence of 50 µM Ca) in combination with 2 mM 6-DMAP or 10 µg mL−1 cycloheximide (CHX) +5 µg mL−1 cytochalasin B (CB) for 4 h. In addition, we studied the effect of elev

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Halpern, Rachel, Victoria Barghout, and Denise Williams. "Compliance with Imatinib Mesylate Associated with Lower Health Resource Utilization and Costs for Patients with CML and GIST." Blood 110, no. 11 (2007): 5159. http://dx.doi.org/10.1182/blood.v110.11.5159.5159.

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Abstract Imatinib mesylate (Gleevec®), has been found both effective and cost-effective for treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST).This study examines the relationship between compliance and health care utilization and costs. This retrospective study used claims from a large national US health plan. Patients (pts) had ≥2 imatinib claims from 6/1/01–3/31/05; ≥1 yr follow-up (F/U) after the 1st imatinib claim; diagnosis of CML (ICD9 205.1 ×) or GIST (ICD9 159.0, 159.8, 159.9 or evaluation of claims by independent hematologist-oncologist). Compliance

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Unger, Alexandra, Andrea Schwarzenlander, and Jan Wilke. "Policies and opportunities for physical activity engagement in Austrian schools: a census survey." PeerJ 12 (August 13, 2024): e17794. http://dx.doi.org/10.7717/peerj.17794.

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Background Compelling evidence suggests that schools’ infrastructure and policy represent potential predictors of health and physical activity (PA) in children and adolescents. However, the translation of these findings into practice has not been examined. This study investigated the activity friendliness of Austrian schools. Methods Using a census sampling method, principals of Austrian schools (n = 342) were invited to participate in an online survey assessing 1) the availability of PA facilities (e.g. playgrounds, sports courts, swimming halls) and 2) applied PA policies (e.g. cooperation w

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Yongwatana, Kachonsak, Ouppatham Supasyndh, and Bancha Satirapoj. "Renal Effects of Sulodexide in Type 2 Diabetic Patients without Nephrotic Range Proteinuria." Journal of Diabetes Research 2020 (August 11, 2020): 1–6. http://dx.doi.org/10.1155/2020/2984680.

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Background. Glycosaminoglycan plays an important role in the maintenance of glomerular charge selectivity of diabetic nephropathy. Sulodexide, a mixture of naturally occurring glycosaminoglycan polysaccharide components, has shown a nephroprotective effect in an experimental model of diabetic nephropathy. Although sulodexide reduced albuminuria in patients with type 1 and type 2 diabetes, long-term effects in patients with type 2 diabetes with significant proteinuria have not been established. Objectives. The study was aimed at investigating the effects of sulodexide on proteinuria and renal f

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Bischoff, Robert, Julian Marcon, Gerald Bastian Schulz, et al. "Perioperative Outcomes and Trends of Surgical Correction of Male Urethral Strictures: Results from the GRAND Study." Journal of Clinical Medicine 14, no. 7 (2025): 2171. https://doi.org/10.3390/jcm14072171.

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Background: While various techniques for the surgical correction of urethral strictures exist, data on their trends and perioperative outcomes are limited. Methods: Data from the German Nationwide Inpatient Data (GRAND) registry (2005–2023) were used to estimate the trends, baseline characteristics, and perioperative outcomes of the surgical techniques for urethral stricture correction. Results: A total of 500,937 patients underwent surgery. Internal urethrotomy was the most frequently performed procedure (n = 413,095, 82%), followed by urethral dilatation (n = 39,619, 8%), meatoplasty (n = 30

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Lee, H. S., D. S. Choi, D. G. Jung, et al. "347 EFFECTS OF NEWBORN CANINE SERUM ON IN VITRO MATURATION OF CANINE OOCYTES." Reproduction, Fertility and Development 19, no. 1 (2007): 289. http://dx.doi.org/10.1071/rdv19n1ab347.

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Research on in vitro maturation (IVM) of canine oocytes has been scant, due to the fact that canine oocytes are at an immature stage (geminal vesicle stage) during ovulation. The most commonly used protein source for IVM of canine oocytes is fetal bovine serum (FBS), estrus bitch serum (EBS), or bovine serum albumin (BSA). However, the IVM rate of canine oocytes is still low. One of the reasons may be that the culture medium is not appropriate enough for canine oocytes in IVM. Therefore, we evaluated the effects of four different protein sources, BSA, FBS, EBS, and newborn canine serum (NBCS),

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Eugster, W., K. Zeyer, M. Zeeman, et al. "Nitrous oxide net exchange in a beech dominated mixed forest in Switzerland measured with a quantum cascade laser spectrometer." Biogeosciences Discussions 4, no. 2 (2007): 1167–200. http://dx.doi.org/10.5194/bgd-4-1167-2007.

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Abstract. Nitrous oxide fluxes were measured at the Lägeren CarboEurope IP flux site over the multi-species mixed forest dominated by European beech and Norway spruce. Measurements were carried out during a four-week period in October–November 2005 during leaf senescence. Fluxes were measured with a standard ultrasonic anemometer in combination with a quantum cascade laser absorption spectrometer that measured N2O, CO2, and H2O mixing ratios simultaneously at 5 Hz time resolution. To distinguish insignificant fluxes from significant ones it is proposed to use a new approach based on the signif

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Woodruff, Sarah J., Katherine Fryer, Ty Campbell, and Mary Cole. "Associations among blood pressure, salt consumption and body weight status of students from south-western Ontario." Public Health Nutrition 17, no. 5 (2013): 1114–19. http://dx.doi.org/10.1017/s1368980013000335.

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AbstractObjectiveThe purpose was to examine the associations among body weight status, blood pressure and daily Na intake among grade 7 students from south-western Ontario, Canada.DesignCross-sectional. Data were collected using the Food Behaviour Questionnaire, including a 24 h diet recall. Measured height and weight were used to determine BMI. Blood pressure was taken manually using mercury sphygmomanometers.SettingTwenty-six schools in south-western Ontario, Canada.SubjectsGrade 7 students (n1068).ResultsBody weight status indicated 1 % were underweight, 56 % normal weight, 23 % overweight

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Ojodeagua-Arredondo, José L., Javier Z. Castellanos-Ramos, J. Jesús Muñoz-Ramos, et al. "EFICIENCIA DE SUELO Y TEZONTLE EN SISTEMAS DE PRODUCCIÓN DE TOMATE EN INVERNADERO." Revista Fitotecnia Mexicana 31, no. 4 (2008): 367. http://dx.doi.org/10.35196/rfm.2008.4.367.

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En México 80 % de la producción hortícola en invernadero se lleva a cabo en suelo y en la restante se utiliza algún tipo de sustrato inerte. En este estudio se determinó el rendimiento comercial, la eficiencia en el uso del agua (EUA) y de nutrimentos del cultivo de tomate (Lycopersicon esculentum Mill. cv. ‘Gironda’) en dos sustratos, suelo y tezontle. El rendimiento comercial en suelo fue de 34.1 kg m-2 con un suministro nutrimental total aplicado de 920, 342, 1520, 1050 y 290 kg ha-1 de N, P2O5, K2O, Ca y Mg respectivamente, y una eficiencia en el uso de nutrimentos de 2.7, 1.0, 4.5, 3.1 y

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Ahn, Chul Woo, Namki Hong, Seunghyun Lee, Hye-Sun Park, Yumie Rhee, and Sungjae Shin. "ODP274 Shift work is associated with normal weight obesity in community-dwelling adults." Journal of the Endocrine Society 6, Supplement_1 (2022): A434—A435. http://dx.doi.org/10.1210/jendso/bvac150.903.

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Abstract Objective Shift working is known to be associated with metabolic syndrome and increased cardiovascular risk. In this study, we aimed to investigate whether shift work is associated with normal weight obesity (NWO), defined as normal weight with high body fat percentage. Method: From the national representative Korea National Health and Nutrition Examination Survey dataset (KNHANES 2008-2011), data of 3800 full-time workers with age≥ 19 years and body mass index (BMI)≤ 25 kg/m 2 were analyzed. In this study, we defined NWO was defined as BMI≤25 kg/m 2 and body fat (BF)percentage≥25% in

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Schartau, Patricia, Laura Horsfall, Irwin Nazareth, Mariam Molokhia, Michael Kirby, and Manuj Sharma. "Trends in reported incidence of erectile dysfunction, hypogonadism, PDE5i prescriptions and TRT in patients with type 2 diabetes in primary care." British Journal of General Practice 69, suppl 1 (2019): bjgp19X703361. http://dx.doi.org/10.3399/bjgp19x703361.

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BackgroundErectile dysfunction (ED) and testosterone deficiency (TD) are complications of type 2 diabetes mellitus (T2DM), and predictors of cardiovascular disease. Guidelines recommend that men with T2DM are assessed and treated for ED/TD, which was included into the Quality and Outcomes Framework (QOF) from 2013–2014 only.AimExplore the effects of QOF on ED/TD diagnoses and management in T2DM patients.MethodThe study population included males (≥18 years) with T2DM and contributing to UK GP electronic health records from 1999–2016. Adjusted incidence rate ratios (IRRs) were estimated using mu

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Spoudeas, H. A., P. C. Hindmarsh, D. R. Matthews, and C. G. D. Brook. "Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study." Journal of Endocrinology 150, no. 2 (1996): 329–42. http://dx.doi.org/10.1677/joe.0.1500329.

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Abstract To determine the aetiopathology of post-irradiation growth hormone (GH) deficiency, we performed a mixed longitudinal analysis of 56 24 h serum GH concentration profiles and 45 paired insulin-induced hypoglycaemia tests (ITT) in 35 prepubertal children, aged 1·5–11·8 years, with brain tumours in the posterior fossa (n=25) or cerebral hemispheres (n = 10). Assessments were made before (n = 16), 1 year (n = 25) and 2 to 5 years (n = 15) after a cranial irradiation (DXR) dose of at least 30 Gy. Fourier transforms, occupancy percentage, first-order derivatives (FOD) and mean concentration

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Philp, Calvin P., Martin Buchheit, Cecilia M. Kitic, Christopher T. Minson, and James W. Fell. "Does Short-Duration Heat Exposure at a Matched Cardiovascular Intensity Improve Intermittent-Running Performance in a Cool Environment?" International Journal of Sports Physiology and Performance 12, no. 6 (2017): 812–18. http://dx.doi.org/10.1123/ijspp.2016-0072.

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Purpose:To investigate whether a 5-d cycling training block in the heat (35°C) in Australian Rules footballers was superior to exercising at the same relative intensity in cool conditions (15°C) for improving intermittent-running performance in a cool environment (<18°C).Methods:Using a parallel-group design, 12 semiprofessional football players performed 5 d of cycling exercise (70% heart-rate reserve [HRR] for 45 min [5 × 50-min sessions in total]) in a hot (HEAT, 35°C ± 1°C, 56% ± 9% RH) or cool environment (COOL, 15°C ± 3°C, 81% ± 10% RH). A 30-15 Intermittent Fitness Test to assess int

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Waikel, Rebekah L., Amna A. Othman, Tanviben Patel, et al. "Recognition of Genetic Conditions After Learning With Images Created Using Generative Artificial Intelligence." JAMA Network Open 7, no. 3 (2024): e242609. http://dx.doi.org/10.1001/jamanetworkopen.2024.2609.

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ImportanceThe lack of standardized genetics training in pediatrics residencies, along with a shortage of medical geneticists, necessitates innovative educational approaches.ObjectiveTo compare pediatric resident recognition of Kabuki syndrome (KS) and Noonan syndrome (NS) after 1 of 4 educational interventions, including generative artificial intelligence (AI) methods.Design, Setting, and ParticipantsThis comparative effectiveness study used generative AI to create images of children with KS and NS. From October 1, 2022, to February 28, 2023, US pediatric residents were provided images through

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Abusoglu, Sedat, Duygu Eryavuz, Ceylan Bal, et al. "Assessment of Serum Ischemia-modified albumin, Prolidase and Thiol-Disulphide Levels in Subjects With Breast Cancer." Revista Romana de Medicina de Laborator 27, no. 1 (2019): 25–33. http://dx.doi.org/10.2478/rrlm-2019-0013.

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Abstract Background: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast cancer and oxidative stress biomarkers. Objectives: In this study, our aim was to find out the oxidative and antioxidant status, serum thiol-disulphide levels in subjects with breast cancer. Methods: This study was conducted between March and June 2018 with 82 control subjects (aged between 32-67 years) and 127 breast cancer patients (aged between 27-66 years) (p=0.058) in Selcuk University Faculty of Medicine, Konya, Turkey. Ser

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McGregor, Veronica P., Salomon Banarer, and Philip E. Cryer. "Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia." American Journal of Physiology-Endocrinology and Metabolism 282, no. 4 (2002): E770—E777. http://dx.doi.org/10.1152/ajpendo.00447.2001.

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We tested the hypothesis that increased endogenous cortisol secretion reduces autonomic neuroendocrine and neurogenic symptom responses to subsequent hypoglycemia. Twelve healthy young adults were studied on two separate occasions, once after infusions of a pharmacological dose of α-(1–24)-ACTH (100 μg/h) from 0930 to 1200 and 1330 to 1600, which raised plasma cortisol levels to ∼45 μg/dl on day 1, and once after saline infusions on day 1. Hyperinsulinemic (2.0 mU · kg−1· min−1) stepped hypoglycemic clamps (90, 75, 65, 55, and 45 mg/dl glucose steps) were performed on the morning of day 2 on b

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