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Journal articles on the topic '342.72 + 340.15(043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Kivitz, A., A. F. Wells, J. Ignacio Vargas, et al. "POS0685 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: FINAL RESULTS FROM THE BALANCE-EXTEND OPEN-LABEL EXTENSION STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 620–21. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1819.

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BackgroundUpadacitinib (UPA) was previously evaluated in two Phase 2, randomized, controlled trials (RCTs) in patients (pts) with rheumatoid arthritis (RA) and inadequate response to tumor necrosis factor inhibitors (BALANCE-1) or methotrexate (BALANCE-2).ObjectivesTo assess the final safety and efficacy of UPA in BALANCE-EXTEND, a 312-week open-label extension (OLE) enrolling pts who completed either BALANCE-1 or BALANCE-2.MethodsAll pts initially received UPA 6 mg twice daily (BID). Increase to 12 mg BID was required for pts with <20% improvement in swollen or tender joint counts (S/TJC)

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Hebden, R. A., M. E. Todd, and J. H. McNeill. "Relationship between atrial granularity and release of atrial natriuretic factor in rats with diabetes mellitus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 257, no. 4 (1989): R932—R938. http://dx.doi.org/10.1152/ajpregu.1989.257.4.r932.

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We examined the effect of a 25% blood volume expansion on the release of atrial natriuretic factor (ANF) in conscious Wistar rats (13-15 wk old) injected 6 wk earlier with streptozotocin (55 mg/kg iv, diabetic) or saline (1 ml/kg iv, control). The diabetic rats demonstrated a significant (P less than 0.05) resting hypotension (132 +/- 2/91 +/- 1 mmHg, systolic/diastolic) and bradycardia (340 +/- 5 beats/min) compared with the controls (145 +/- 2/98 +/- 2 mmHg, 377 +/- 8 beats/min). Resting plasma immunoreactive (IR) ANF levels were significantly (P less than 0.05) elevated in the diabetic rats

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Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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Overcash, J. Scott, William O’Riordan, Megan Quintas, Laura Lawrence, Carol Tseng, and Sue Cammarata. "470. Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in Patients with Significant Drug Abuse: Outcomes from Global Phase 3 Studies of Delafloxacin (DLX)." Open Forum Infectious Diseases 6, Supplement_2 (2019): S230. http://dx.doi.org/10.1093/ofid/ofz360.543.

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Abstract Background Delafloxacin (DLX), an IV/oral anionic fluoroquinolone antibiotic, is approved for the treatment of ABSSSI including those due to MRSA and Gram-negative pathogens including P. aeruginosa. Two global phase 3 ABSSSI trials included patients with substance abuse including IV drugs. Methods Two multicenter, double-blind, double-dummy trials of adults with ABSSSI randomized patients 1:1 to receive either DLX monotherapy or vancomycin 15 mg/kg + aztreonam (VANAZ) for 5–14 days. Study 302 used DLX 300 mg BID IV only; study 303 used DLX 300 mg BID IV for 3 days with a mandatory bli

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Vieira Bento Silva, A. D., M. H. Fernandes Lourenco, S. Ramiro, et al. "POS0678 PERFORMANCE OF CLINICAL, LABORATORY AND IMAGING FEATURES FOR THE DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS - A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 621.1–621. http://dx.doi.org/10.1136/annrheumdis-2023-eular.108.

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BackgroundThe Berlin algorithm for axial spondyloarthritis (axSpA) diagnosis was developed more than 15 years ago. New evidence suggests that the diagnostic performance of some SpA features might not be as good as initially thought.ObjectivesTo review the evidence on the performance of SpA features for axSpA diagnosis.MethodsSystematic literature review and meta-analysis of studies (2004-2021) reporting data on ≥1 SpA feature. The population was defined as adults (≥16 years) with a suspicion or definite clinical diagnosis of axSpA. The diagnostic performance of each SpA feature was tested agai

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Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 850.1–850. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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Herrero-Morant, A., J. Loricera, I. Ferraz-Amaro, et al. "AB0707 PREDICTIVE FACTORS OF RELAPSE IN GIANT CELL ARTERITIS TREATED WITH TOCILIZUMAB." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1557.2–1558. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4399.

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BackgroundTocilizumab (TCZ) is the only biologic therapy approved for giant cell arteritis (GCA). Clinical trials with TCZ in GCA was performed with intravenous (iv) TCZ in a phase 2 trial[1], and with subcutaneous (sc) TCZ in the phase 3 GiACTA[2].There is general agreement on the initial/maintenance dose, but duration of TCZ therapy is not well established. In GiACTA trial, after one year on TCZ, most patients had GCA relapse after withdrawal.ObjectivesTo assess the predictive factors of relapse in GCA in a clinical practice scenario.MethodsMulticentre observational study of 471 patients wit

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Sakamoto, Tomohiro, Taichi Matsubara, Takayuki Takahama, et al. "Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer." JAMA Network Open 6, no. 12 (2023): e2347700. http://dx.doi.org/10.1001/jamanetworkopen.2023.47700.

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ImportanceBiomarker testing for driver mutations is essential for selecting appropriate non–small cell lung cancer (NSCLC) treatment but is insufficient.ObjectiveTo investigate the status of biomarker testing and drug therapy for NSCLC in Japan for identifying problems in treatment.Design, Setting, and ParticipantsThe REVEAL cohort study included retrospective data collection and prospective follow-up from 29 institutions across Japan. Of 1500 patients diagnosed with advanced or recurrent NSCLC between January 1 and March 18, 2021, 1479 were eligible. Cases recognized at the wrong clinical sta

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Serdán Ruiz, David Leonardo, Katterine Kariuxy Vásquez Bone, and Ana Emperatriz Yupa Pallchisaca. "LAS INFECCIONES EN EL TRACTO URINARIO EN LA MUJER EMBARAZADA Y SU INCIDENCIA EN LA MORBILIDAD Y MORTALIDAD DE NEONATOS." Universidad Ciencia y Tecnología 24, no. 106 (2020): 102–8. http://dx.doi.org/10.47460/uct.v24i106.402.

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La infección del tracto urinario de origen bacteriano es una patología frecuente en la mujer embarazada. Constituye un importante factor de riesgo asociado con el desarrollo de sepsis neonatal. La sepsis neonatal es una infección invasiva generalmente acompañada de bacteriemia que se presenta en el neonato en el primer mes de vida. Es una de las causas principales de morbilidad y mortalidad neonatal. El objetivo de esta investigación fue mostrar la relación entre la infección en el tracto urinario en la madre embrazada y la morbilidad y mortalidad del neonato. Se realizó un estudio de casos y

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Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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Kristanto, Wisnu. "Javanese Traditional Songs for Early Childhood Character Education." JPUD - Jurnal Pendidikan Usia Dini 14, no. 1 (2020): 169–84. http://dx.doi.org/10.21009/141.12.

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   Character education in early childhood is not new, and character education is also not just a transfer of knowledge, but something that needs to be built early on through various stimula- tions. This study aims to develop the character of early childhood through audio-visual media with traditional Javanese songs. Using educational design-based research to develop audio-visual media from traditional songs, this media was tested in the field with an experimental design with a control group. Respondents involved 71 kindergarten students from one experimental class in one cont

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AYANKOSO, Micheal Taiwo, Damilola Miracle OLUWAGBAMILA, and Olugbenga Samson ABE. "EFFECTS OF ACTIVATED CHARCOAL ON LIVESTOCK PRODUCTION: A REVIEW." Slovak Journal of Animal Science 56, no. 01 (2023): 46–60. http://dx.doi.org/10.36547/sjas.791.

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Aerts, R. (1997). Nitrogen partitioning between resorption and decomposition pathways: a trade-off between nitrogen use efficiency and litter decomposability? Oikos, 80(3), 603−406. Ahmedna, M., Marshall, W. E. & Rao, R. O. (2000). Granular Activated Carbons from Agricultural By-Products: Preparation, Properties, and Application in Cane Sugar Refining. LSU AgCenter: Bulletin Number 869. Albiker, D. & Zweifel, R. (2019). Pflanzenkohle im Futter oder in der Einstreu und ihre Wirkung auf die Stickstoffretention und Leistung von Broilern. Wissenschaftstagung Ökologischer Landbau. Kassel: S

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Bresee, Lauren C., Nicole Lamont, Wrechelle Ocampo, et al. "Implementation strategies for hospital-based probiotic administration in a stepped-wedge cluster randomized trial design for preventing hospital-acquired Clostridioides difficile infection." BMC Health Services Research 23, no. 1 (2023). http://dx.doi.org/10.1186/s12913-023-10350-9.

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Abstract Background Clostridioides difficile infection (CDI) is associated with considerable morbidity and mortality in hospitalized patients, especially among older adults. Probiotics have been evaluated to prevent hospital-acquired (HA) CDI in patients who are receiving systemic antibiotics, but the implementation of timely probiotic administration remains a challenge. We evaluated methods for effective probiotic implementation across a large health region as part of a study to assess the real-world effectiveness of a probiotic to prevent HA-CDI (Prevent CDI-55 +). Methods We used a stepped-

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Gibble, T. H., D. Cao, T. D. Forrester, and J. F. Brumm. "8366 Weight Reduction is Associated with Improved Quality of Life in Patients in SURMOUNT-3." Journal of the Endocrine Society 8, Supplement_1 (2024). http://dx.doi.org/10.1210/jendso/bvae163.053.

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Abstract Disclosure: T.H. Gibble: Employee; Self; Eli Lilly & Company. Stock Owner; Self; Eli Lilly & Company. D. Cao: Employee; Self; Eli Lilly & Company. Stock Owner; Self; Eli Lilly & Company. T.D. Forrester: Employee; Self; Eli Lilly & Company. Stock Owner; Self; Eli Lilly & Company. J.F. Brumm: Employee; Self; Eli Lilly & Company. Stock Owner; Self; Eli Lilly & Company. Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, is approved in the US for treatment of type 2 diabetes and obesity. In S

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Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." May 25, 2021. https://doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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Srinivas, Amedapu, and Leela Velusamy. "Community Detection Algorithm Based on High Degree Node Selection in Complex Networks." Journal of Machine and Computing, July 5, 2025, 1864–72. https://doi.org/10.53759/7669/jmc202505146.

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B. Kamiński, P. Prałat, and F. Théberge, “Mining Complex Networks,” Nov. 2021, doi: 10.1201/9781003218869. S. S. Hussein and A. A. Farhan, “On Linear Algebraic and Graph Theoretic Methods,” Journal of Global Scientific Research, vol. 8, no. 11, pp. 3319–3326, 2023. C. He, X. Fei, Q. Cheng, H. Li, Z. Hu, and Y. Tang, “A Survey of Community Detection in Complex Networks Using Nonnegative Matrix Factorization,” IEEE Transactions on Computational Social Systems, vol. 9, no. 2, pp. 440–457, Apr. 2022, doi: 10.1109/tcss.2021.3114419. F. Gasparetti, G. Sansonetti, and A. Micarelli, “Community detecti

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McLeod, Charlie, Michael Dymock, Katie Flanagan, et al. "P-98. The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): the immunogenicity, reactogenicity, and safety of different COVID-19 vaccinations administered as a second booster (fourth dose) in BNT162b2 primed individuals aged 18-< 50 and 50-< 70 years old." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.305.

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Abstract Background PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. Here, we report data for second boosters among individuals aged 18-&lt; 50 and 50-&lt; 70 years old primed with BNT162b2 (18-&lt; 50y-BNT162b2 and 50-&lt; 70y-BNT162b2, respectively) until Day (D) 84. CONSORT diagram for participants recruited to the 18-&lt;50y-BNT162b2 (A) and 50-&lt;70y-BNT162b2 (B) strata for second booster vaccines. Participants were excluded from subsequent analyses if they were infected with COVID-19

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sprotocols. "Preparation of materials for flexizyme reactions and genetic code reprogramming." January 24, 2015. https://doi.org/10.5281/zenodo.14305.

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Authors: Yuki Goto, Takayuki Katoh & Hiroaki Suga ### Abstract Genetic code reprogramming is a method for the reassignment of arbitrary codons from proteinogenic amino acids to non-proteinogenic ones, and thus specific sequences of non-standard peptides can be ribosomally expressed according to their mRNA templates. We have developed a protocol that facilitates the genetic code reprogramming using flexizymes integrated with a custom-made in-vitro translation apparatus, referred to as the flexible in-vitro translation (FIT) system. Flexizymes are flexible tRNA acylation ribozymes that enabl

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sprotocols. "A simple improvement of the conventional cryopreservation for human ES and iPS cells." December 31, 2014. https://doi.org/10.5281/zenodo.13659.

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Authors: Midori Ozawa, Yutaka Ozawa, Masashi Iemura, Arihiro Kohara, Kana Yanagihara & Miho K Furue ### Abstract In this study, a simple method for the cryopreservation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is proposed. It is based on the conventional slow-freezing method with 10% DMSO and modified mainly in a thawing protocol without specific equipment or reagents. Recovery rate of the cells cryopreserved by this method was equally high, which is comparable to that of the cells frozen by the vitrification method. In the case of vitrification method, it requ

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sprotocols. "High Resolution Melting Analysis for fast and cheap polymorphism screening of marine populations." January 14, 2015. https://doi.org/10.5281/zenodo.13940.

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Authors: Anne-Leila Meistertzheim, Isabelle Calves, Sébastien Artigaud, Carolyn S. Friedman, Christine Paillard, Jean Laroche & Claude Ferec ### Abstract This protocol permits the mutation scanning of PCR products by high-resolution DNA melting analysis requiring the inclusion of a saturating intercalating dye in the PCR mix without labelled probe. During a scanning process, fluorescent melting curves of PCR amplicons are analyzed. Mutations modifying melting curve shapes, are allowed to be further characterized by sequencing because melting is not destructive. The method detects on small

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Kojo, Kosuke, Tomoko Oguri, Takazo Tanaka, et al. "Seminal plasma metallomics: a new horizon for diagnosing and managing male infertility." Revista Internacional de Andrología 23, Published Ahead of Print (2025). https://doi.org/10.22514/j.androl.2025.013.

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The authors, Kosuke Kojo and Tomoko Oguri, contributed equally. This HTML edition is publicly accessible at the following URL:https://academic298uro.github.io/open-archive/2025/seminal-plasma-metallomics-new-horizon/ Abstract Seminal plasma contains a wide range of biomolecules—including inorganic elements—that may significantly influence male reproductive function. Historically, semen analysis has focused on sperm count and motility, while overlooking the diagnostic potential of this acellular fraction. This narrative review synthesizes historical perspectives on seminal plasma me

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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