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Journal articles on the topic '343.1 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Chen, Liqin, Laurence K. Thompson, and John N. Bridson. "Coordination chemistry of thioether–pyridazine macrocycles II. Synthesis, structural and spectroscopic studies of dinuclear copper(II) and polynuclear copper(I) and silver(I) complexes of a tetrathiapyridazinophane macrocyclic ligand." Canadian Journal of Chemistry 70, no. 11 (1992): 2709–16. http://dx.doi.org/10.1139/v92-343.

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The preparation and properties of the thioether–pyridazine macrocycle (L3; C11H16N2S4) containing one pyridazine subunit, and its copper(II), copper(I), and silver(I) complexes are described. Magnetic susceptibility data (5–300 K) for the binuclear complexes [CuL3Cl2]2 (I) and [CuL3Br2]2 (II) have been fitted to the Friedberg magnetization expression with a molecular field correction. Intradimer antiferromagnetic exchange is weak (−2J < 18 cm−1), with even weaker interdimer exchange (−zJ′ < 0.3 cm−1). The complexes [CuL3Cl]x (III) and [AgL3ClO4]x (V) have been characterized by X-ray crys

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Sedziol, Carley, Sari Bosnyak, Nadja Knox, Haley Ravia, and Clarence E. Ferguson. "PSXV-16 Association of Experience and pre-Race Behavior in Performance Among Racing Quarter Horses." Journal of Animal Science 100, Supplement_3 (2022): 294. http://dx.doi.org/10.1093/jas/skac247.534.

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Abstract The annual average cost of maintaining a racehorse will typically outweigh its earning, making it important that the horse performs above average. The goal of this study was to investigate if the age or experience level of a racehorse could be associated with performance. This study observed pre-racing Quarter Horses (n = 1,033) behavior during one racing season at Delta Downs racetrack (Vinton, LA). The horses were placed into groups based on race experience (0-2, 3-10, and 11+ total races). Horse pre-race before saddling (BSAD), saddling (SAD), after saddling (ASAD) and post-parade

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Piatti, Andrés E. "Globular Cluster Candidates in the Sagittarius Dwarf Galaxy." Astronomical Journal 162, no. 6 (2021): 261. http://dx.doi.org/10.3847/1538-3881/ac2833.

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Abstract Recently, new Sagittarius (Sgr) dwarf-galaxy globular clusters were discovered, which opens the question of the actual size of the Sgr globular cluster population, and therefore on our understanding of the Sgr galaxy formation and accretion history of the Milky Way. Based on Gaia EDR3 and SDSS IV DR16 (APOGEE-2) data sets, we performed an analysis of the color–magnitude diagrams (CMDs) of the eight new Sgr globular clusters found by Minniti et al. from a sound cleaning of the contamination of Milky Way and Sgr field stars, complemented by available kinematic and metal abundance inform

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Somogyi, G. T., and W. C. de Groat. "Modulation of release of [3H]acetylcholine in the major pelvic ganglion of the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 6 (1993): R1084—R1088. http://dx.doi.org/10.1152/ajpregu.1993.264.6.r1084.

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Cholinergic modulation of [3H]acetylcholine release evoked by electrical stimulation was studied in the rat major pelvic ganglion, which was prelabeled with [3H]choline. Acetylcholine (ACh) release was independent of the frequency of stimulation; 0.3 Hz produced the same volley output as 10 Hz. Tetrodotoxin (1 microM) or omission of Ca2+ from the medium abolished ACh release. The M1 receptor agonist (4-hydroxy-2-butynyl)-1-trimethylammonium m-chlorocarbanilate chloride (McN-A 343, 50 microM) increased release (by 136%), whereas the M2 muscarinic agonist oxotremorine (1 microM) decreased ACh re

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Ashwini, D., T. Sankarappa, M. Amarkumar, et al. "Dielectric relaxation studies in Sm₂O₃ doped boro-zinc-vanadate glasses." IOP Conference Series: Materials Science and Engineering 1300, no. 1 (2024): 012044. http://dx.doi.org/10.1088/1757-899x/1300/1/012044.

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Abstract In this work, the conventional melting procedure was adopted to synthesize glasses with a composition of (ZnO)0.3 – (V2O5)0.3 – (B2O3)0.4-x – (Sm2O3)x, x = 0.002, 0.005, 0.007, 0.01 and 0.02 mol%. The dielectric properties of these glasses were measured. The dielectric constant (εʹ) and dielectric loss (εʹʹ) of glasses are found to vary in the range from 1.9177x102 to 3.9456x103 and from 1.5751 to 6.9095x105 respectively for the temperature range 343 K – 573 K and frequency range 50 Hz to 10 MHz. With increase of frequency, both dielectric constant and loss decreased and increased wit

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Yee, Timothy Joseph, Cheerag D. Upadhyaya, Domagoj Coric, et al. "288 Impact of Disc Degeneration on Clinical Outcomes After Fusion for Grade 1 Spondylolisthesis: A 5-year QOD Study." Neurosurgery 70, Supplement_1 (2024): 82. http://dx.doi.org/10.1227/neu.0000000000002809_288.

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INTRODUCTION: Disc degeneration with loss of disc height can be an indication to fuse patients with lumbar spondylosis. However, its relevance for spondylolisthesis is unknown. METHODS: The Quality Outcomes Database was queried for adult patients who underwent fusion for single-level degenerative grade 1 lumbar spondylolisthesis. Pfirrmann grade at the level to be fused was assessed on preoperative sagittal T2-weighted MRI. VAS-back pain (BP-VAS), VAS-leg pain (LP-VAS), and ODI were collected preoperatively and at 3, 12, 24, 36, and 60 months postoperatively. RESULTS: The query returned 395 pa

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Hempe, Sebastian, Ajay Moza, Andreas Goetzenich, et al. "Synchronous or Staged Carotid Endarterectomy and Coronary Artery Bypass Grafting? Propensity score matched study." Heart Surgery Forum 21, no. 5 (2018): E359—E364. http://dx.doi.org/10.1532/hsf.2074.

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Background: The optimal treatment strategy in patients presenting with hemodynamically significant carotid artery disease who are to undergo cardiac surgery, remains controversial. In this study, we retrospectively analyzed the outcome data of patients receiving synchronous or staged coronary artery bypass graft (CABG) surgery and carotid endarterectomy (CEA).  Methods: Between 2011 and 2016, 3173 patients underwent CABG surgery in our institution, of whom 323 received CABG and CEA either as synchronous (N = 307) or as staged (N = 16) procedures. Patients´ characteristics, peri- and post

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Dykstra, Rachel, Panagiotis Koutakis, and Nicholas Hanson. "Relationship Between Physical Fitness Variables and Reaction Time in eSports Gamers." International Journal of eSports Research 1, no. 1 (2021): 1–14. http://dx.doi.org/10.4018/ijer.288540.

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eSports gaming requires quick and accurate reactions in response to complex visual stimuli for optimal performance. The purpose of this study was to examine the relationship between components of physical fitness and reaction time (RT) in eSports gamers. 27 eSports gamers participated. Visit 1 included physical fitness assessments. Visit 2 included a familiarization with the Stroop Task. During Visit 3, subjects completed the Stroop Task again; data from this visit was used for analyses. For congruent, incongruent and control trials, an inverse efficiency score (IES) was calculated. Pearson co

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Hidayat, N., Y. D. Nugrahany, V. R. Permatasari, and I. Nurika. "Optimization of dissolved proteins in extracts of earthworm (Lumbricus rubellus) with factor adding concentration of papain enzyme and earthworms." IOP Conference Series: Earth and Environmental Science 924, no. 1 (2021): 012076. http://dx.doi.org/10.1088/1755-1315/924/1/012076.

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Abstract Earthworms (Lumbricus rubellus) can be used as an alternative to meet protein needs. This study aimed to obtain optimal N-Amino and Total Soluble Solid (TSS) results in earthworm extract. Efforts to improve the results of N-Amino and TDS (Total Dissolved Solids) in earthworm extract can be done by hydrolyzing the juice of earthworms with the help of enzyme protease papain under certain conditions, so it will facilitate the process of solving protein content. The experimental design in this study was Surface Methodology Response (RSM) model using thirteen models and two factors, namely

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Ambarwati, Dinar, Ida H. Soemantri, Dwinita W. Utami, Aniversari Apriana, and Sugiono Moeljopawiro. "Rice Anther Culture to Develop Double Haploid Population and Blast Resistant Lines." Jurnal AgroBiogen 5, no. 2 (2009): 71. http://dx.doi.org/10.21082/jbio.v5n2.2009.p71-77.

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<p>Penyakit blas pada padi yang disebabkan<br />oleh cendawan Pyricularia grisea, merupakan salah satu<br />kendala dalam produksi beras. Sumber gen ketahanan terhadap<br />penyakit blas dijumpai pada spesies padi liar Oryza<br />rufipogon. Populasi silang ganda (BC2F3) turunan IR64 dan<br />O. rufipogon mempunyai QTL untuk sifat ketahanan terhadap<br />penyakit blas. Untuk mempercepat perolehan tanaman<br />homosigot dari populasi tersebut, dilakukan kultur anter<br />pada dua media induksi kalus: I1 (N6 + NAA 2 mg/l + kinetin<br />0

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Hamrin Senorski, Eric, Eleonor Svantesson, Susanne Beischer, et al. "Factors Affecting the Achievement of a Patient-Acceptable Symptom State 1 Year After Anterior Cruciate Ligament Reconstruction: A Cohort Study of 343 Patients From 2 Registries." Orthopaedic Journal of Sports Medicine 6, no. 4 (2018): 232596711876431. http://dx.doi.org/10.1177/2325967118764317.

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Background: There is insufficient knowledge regarding the influence of concomitant injuries on the recovery of short-term subjective knee function after anterior cruciate ligament (ACL) reconstruction. Purpose: To determine whether patient characteristics, concomitant injuries, and graft choice during ACL reconstruction can predict which patients achieve acceptable knee function 1 year after reconstruction. Study Design: Case-control study; Level of evidence, 3. Methods: Data from 1 physical therapist–specific and 1 surgeon-specific register were used. Patients who had completed the Knee injur

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Clark, Anna. "A. La Regina, Lexicon Topographicum Urbis Romae Suburbium. Volume Primo A–B. Rome: Edizioni Quasar, 2001. Pp. 343, 221 figs, 1 loose map. ISBN 88-7097-044-2. €134.00." Journal of Roman Studies 94 (November 2004): 211–12. http://dx.doi.org/10.2307/4135035.

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Clark, Anna. "A. La Regina, Lexicon Topographicum Urbis Romae Suburbium. Volume Primo A–B. Rome: Edizioni Quasar, 2001. Pp. 343, 221 figs, 1 loose map. ISBN 88-7097-044-2. €134.00." Journal of Roman Studies 94 (November 2004): 211–12. http://dx.doi.org/10.1017/s0075435800064431.

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Dudko, V. A., T. I. Klepcha, A. L. Lipnitski, T. V. Sergievich, and A. V. Marochkov. "INFLUENCE OF PERIOPERATIVE FACTORS ON THE LEVEL OF CORTISOL IN ANESTHESIA DURING CARDIAC SURGERY." Journal of the Grodno State Medical University 20, no. 3 (2022): 343–47. http://dx.doi.org/10.25298/2221-8785-2022-20-3-343-347.

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Background. In this study the dependence of the level of cortisol on the age of the patient, the presence of disorders of fat metabolism, the dose of muscle relaxant and anesthetic propofol was revealed. Determining the level of cortisol as a component of anesthetic monitoring enables not only to assess the level of perioperative stress, but also to predict the height of the expected stress response. The aim of our study was to determine the influence of perioperative factors on cortisol levels during cardiac surgery. Material and methods. A prospective non-randomized observational study was c

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García, Botella A., la Serna Esteban S. De, Antoñanzas L. López, et al. "Lessons Learned in Elective Surgeries After 6 Pandemic Waves of SARS-CoV-2. A Single European Center Experience." World Journal of Surgery 47 (June 5, 2023): 2958–65. https://doi.org/10.1007/s00268-023-07222-y.

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<strong>Background: </strong>The reported high surgical morbidity and mortality in patients with SARS-CoV-2 prompted preoperative screening and modification of surgical protocols. Although vaccination and treatment of COVID-19 have resulted in lower hospitalization rates and infection severity, publications on postoperative results have not been updated. The aim of the study was to analyze the outcomes of patients undergoing surgery in two periods with high incidence of SARS-CoV-2 infection, before and after vaccination. <strong>Materials and methods: </strong>This is a prospective c

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Yarullin, A. R., A. N. Teregulova, S. L. Khursan, and R. L. Safiullin. "ABSOLUTE RATE CONSTANTS OF CONSUMPTION OF ISOMERS OF AROMATIC NITROSO OXIDES 4-R-C6H4CH2-C6H4NOO, R = OH, NHCOCH3." Izvestia Ufimskogo Nauchnogo Tsentra RAN, no. 2 (June 16, 2025): 102–7. https://doi.org/10.31040/2222-8349-2025-0-2-102-107.

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The decay kinetics of cis- and trans-isomers of aromatic nitroso oxides 4-R-C6H4CH2-C6H4NOO (R = OH, NHCOCH3) was studied by pulse photolysis and electron spectrophotometry at 279 – 343 K in acetonitrile solutions. The effective rate constants kcis and ktrans, as well as their activation parameters, were determined. Aromatic nitroso oxides ArNOO were generated by photolysis of the corresponding azides ArN3 in aerated ace tonitrile solutions. It was found that lgkcis (s-1) = (11.7 ± 0.5) – (64.2 ± 2.6)/ for R = OH and (13.1 ± 0.1) – (72.4 ± 0.1)/ for R = NHCOCH3,  = 2.303RT kJ/mol. According

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Wang, Ju, Jianping Xiao, Ruifeng Wang, and Deguang Wang. "Influencing factors of cardiac valve calcification (CVC) in patients with chronic kidney disease and the impact of CVC on long-term prognosis: a single-center retrospective study." PeerJ 11 (June 30, 2023): e15569. http://dx.doi.org/10.7717/peerj.15569.

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Objective To investigate the effect of cardiac valve calcification (CVC) on the prognosis of patients with chronic kidney disease (CKD). Methods A total of 343 CKD patients were retrospectively analyzed, and divided into two groups according to the presence or absence of cardiac valve calcification. All patients were followed until death, loss to follow-up, or the end point of the study (December 2021). Results The incidence of CVC among the 343 CKD patients was 29.7%, including 21 cases of mitral valve calcification, 63 cases of aortic valve calcification, and 18 cases of mitral valve combine

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Medeiros, Thales M., João B. Ribeiro-Alvares, Carolina G. Fritsch, et al. "Effect of Weekly Training Frequency With the Nordic Hamstring Exercise on Muscle-Strain Risk Factors in Football Players: A Randomized Trial." International Journal of Sports Physiology and Performance 15, no. 7 (2020): 1026–33. http://dx.doi.org/10.1123/ijspp.2018-0780.

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Purpose: To examine the differences between performing Nordic hamstring exercises once or twice a week on hamstring eccentric strength and other muscle-strain risk factors in high-level football players. Methods: In this randomized trial, 32 football players (18–23 y old) completed an 8-week Nordic hamstring exercise training program in 1 of 2 experimental groups: group 1 (once a week; n = 15) and group 2 (twice a week; n = 17). Knee-flexor/extensor peak torques and biceps femoris long-head muscle architecture were assessed through isokinetic dynamometry and ultrasonography, respectively, befo

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Uslu Yurteri, E., M. E. Yayla, B. Atmaca Haktaniyan, et al. "AB1462 EFFECTIVENESS OF THE STILL ACTIVITY SCORE IN ADULT-ONSET STILL’S DISEASE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1959.1–1959. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3959.

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BackgroundAdults Still’s disease is a rare autoinflammatory disorder with an unknown etiology, characterized by fever, arthritis, and rash. There is no method to fully evaluate the disease’s activity [1].ObjectivesThe Still Activity Score (SAS) is a newly defined, easy-to-use disease activity assessment score for Still disease [2]. We aimed to compare the efficacy of the Modified Pouchot Activity Score (mPouchot), Systemic Feature Score (SFS), and Still Activity Score (SAS) [2-4].MethodsThe study included 45 patients diagnosed with Still between 2010 and 2022 who met the Yamaguchi criteria. Th

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Rüland, Anna, Karl-Philipp Gloning, Matthias Albig, et al. "The Incidence of Chromosomal Aberrations in Prenatally Diagnosed Isolated Agenesis of the Corpus Callosum." Ultraschall in der Medizin - European Journal of Ultrasound 38, no. 06 (2017): 626–32. http://dx.doi.org/10.1055/s-0043-113818.

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Abstract Purpose To establish the prevalence of chromosomal aberrations in fetuses with an apparently isolated agenesis of the corpus callosum (ACC) on prenatal ultrasound. Materials & Methods This was a retrospective study of complete isolated ACC at the time of ultrasound evaluation with respect to karyotype information. Within this group, a subgroup with non-malformation minor abnormalities, such as a single umbilical artery (SUA), polyhydramnios or fetal growth restriction (FGR), was investigated. Results Complete ACC was diagnosed in 343 cases. Of them, 143 (41.6 %) were isolated, wit

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Hebbard, G. S., M. Samsom, W. M. Sun, J. Dent, and M. Horowitz. "Hyperglycemia affects proximal gastric motor and sensory function during small intestinal triglyceride infusion." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 5 (1996): G814—G819. http://dx.doi.org/10.1152/ajpgi.1996.271.5.g814.

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Hyperglycemia slows gastric emptying in normal individuals and patients with diabetes mellitus and may affect both somatic and visceral sensation. The effects of hyperglycemia on proximal gastric motility and sensation during intraduodenal infusion of a triglyceride emulsion were evaluated using a barostat in six normal subjects during euglycemia and hyperglycemia (approximately 15 mmol/l). Isobaric distension induced greater bag volumes during hyperglycemia compared with euglycemia at 3 (452 +/- 26 vs. 343 +/- 12 ml, P< 0.05) and 4 mmHg (600 +/- 55 vs. 497 +/- 50 ml, P < 0.05) above bas

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Nimmagadda, Padmaja, and Nageswara Rao Gollapalli. "Effect of propanediol on chemical speciation of phenanthroline complexes of toxic metals." Journal of Indian Chemical Society Vol. 89, Jul 2012 (2012): 955–57. https://doi.org/10.5281/zenodo.5767058.

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Department of Chemistry, Ani! Neerukonda Institute of Technology and Sciences, Sangivalasa, Visakhapatnam-531 162, Andhra Pradesh, India school of Chemistry, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India <em>E-mail </em>: gollapallinr@yahoo.com <em>Manuscript received 16 June 2011, revised 15 November 2011, accepted 21 November 2011</em> The stability of the binary complexes of toxic metal ions such as Pb<sup>II</sup> , Cd<sup>ll</sup> and Hg<sup>ll</sup> with 1,10-phenanthrolinc is studied by pH metry in (0.0-60.0% v/v) 1,2-propanediol-water mixtures at 303 K and 0.16 mol L<

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West, Stephen W., Sean Williams, Peter Tierney, et al. "Training and match load in professional rugby union: Do contextual factors influence the training week?" South African Journal of Sports Medicine 33, no. 1 (2021): 1–6. http://dx.doi.org/10.17159/2078-516x/2021/v33i1a9509.

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    Background: Rugby union demands a multifaceted approach to training, given the multiple physical and technical attributes required to play the sport. Objectives: The aim of this study is to describe the distribution of training throughout the week and investigate how this may be influenced by match-related factors. Methods: Training load data (session Rating of Perceived Exertion [sRPE], total distance and high-speed running [HSR]) were collected from six professional English rugby teams during the 2017/18 season. Five contextual factors were also recorded inc

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Cotwright, Caree J., Diane W. Bales, Jung Sun Lee, Kathryn Parrott, Nathalie Celestin, and Babatunde Olubajo. "Like Peas and Carrots: Combining Wellness Policy Implementation With Classroom Education for Obesity Prevention in the Childcare Setting." Public Health Reports 132, no. 2_suppl (2017): 74S—80S. http://dx.doi.org/10.1177/0033354917719706.

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Objectives: We evaluated an intervention combining policy training and technical assistance for childcare teachers with a nutrition education curriculum to improve (1) the knowledge and self-efficacy of childcare teachers in implementing obesity prevention policies and practices, (2) the quantity and quality of nutrition and physical activity education, and (3) the childcare wellness environment. Methods: Thirteen teachers and 8 administrators (2 of whom were also teachers) from 8 childcare programs in Clarke County, Georgia, participated in the Healthy Child Care Georgia intervention during J

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Kuźmicz, Agnieszka, Arti Goyal, Stanisław Zola, et al. "Optical Variability of Eight FRII-type Quasars with 13 yr Photometric Light Curves." Astrophysical Journal Supplement Series 263, no. 1 (2022): 16. http://dx.doi.org/10.3847/1538-4365/ac9622.

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Abstract We characterize the optical variability properties of eight lobe-dominated radio quasars (QSOs): B2 0709+37, FBQS J095206.3+235245, PG 1004+130, [HB89] 1156+631, [HB89] 1425+267, [HB89] 1503+691, [HB89] 1721+343, and 4C +74.26, systematically monitored for a duration of 13 yr since 2009. The quasars are radio-loud objects with extended radio lobes that indicate their orientation close to the sky plane. Five of the eight QSOs are classified as giant radio quasars. All quasars showed variability during our monitoring, with magnitude variations between 0.3 and 1 mag for the least variabl

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Molina Centeno, Julio Cesar, Sergio Cuadra, Mauricio Guzmán, Noel Duarte, and Aurelio Llano. "ADAPTACIÓN Y RENDIMIENTO DE LA VARIEDAD DE FRIJOL INTA VAINA ROJA, PARA TOLERANCIA A SEQUÍA Y MANCHA ANGULAR EN CUATRO REGIONES DE NICARAGUA." La Calera 13, no. 20 (2014): 24–30. http://dx.doi.org/10.5377/calera.v13i20.1621.

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El presente trabajo se llevó a cabo entre los años 2005 y 2007, con el objetivo de evaluar la adaptación y rendimiento de la variedad mejorada INTA Vaina Roja, en las zonas de Las Segovias, Centro Norte, Centro Sur y Pacífico Sur de Nicaragua. En el año 2006 se condujeron nueve ensayos de rendimiento, uno en Madriz, cinco en Estelí, uno en Matagalpa y dos en Jinotega. En las etapas preliminares de rendimiento, el ensayo incluyó 51 líneas F8, y en las pruebas avanzadas de rendimiento se incluyeron 34 líneas F9 y 14 líneas F8 y F9. Estos trabajos se realizaron de acuerdo a las condiciones agroec

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Simioni, Fabiano Luís, Ivo Francisco de Andrade, Márcio Machado Ladeira, Tarcisio de Moraes Gonçalves, João Irineo da Mata Júnior, and Fabrício Rodrigues Campos. "Níveis e frequência de suplementação de novilhos de corte a pasto na estação seca." Revista Brasileira de Zootecnia 38, no. 10 (2009): 2045–52. http://dx.doi.org/10.1590/s1516-35982009001000027.

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Objetivou-se avaliar os níveis de suplementação proteico-energética, oferecida em diferentes frequências, a animais em recria mantidos em pastagem de Bracharia decumbens na estação seca do ano. Foram utilizados 25 novilhos não-castrados, com peso inicial médio de 191 kg, distribuídos em delineamento de blocos casualizados, com cinco repetições por tratamento, em arranjo fatorial 2 × 2 + 1, ou seja, dois níveis de suplementação energético-proteica (0,3 e 0,6% em relação ao peso vivo (PV) do animal), duas frequências de fornecimento - diariamente ou em dias alternados (dia sim, dia não) - mais u

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Luu, Huong, Gerald Spotts, Hartwig Gajek, et al. "ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin- Free Method] Post-Authorization Safety Surveillance (PASS): Safety and Efficacy Following Product Switch in Routine Clinical Practice." Blood 112, no. 11 (2008): 3375. http://dx.doi.org/10.1182/blood.v112.11.3375.3375.

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Abstract A prospective, non-interventional Post-Authorization Safety Surveillance (PASS) program was initiated in 2004 to document ADVATE safety and efficacy in routine clinical practice. More than 900 subjects newly prescribed ADVATE have been enrolled in the US, EU and Japan alone. Herein, we present final US and interim EU results comprising 506 treated subjects, 451 of which have completed the 1-year observation period and 20 ongoing. Age cohorts were as follows: 27 neonates/infants (0-<2 years), 128 children (2-<12 years), 54 adolescents (12-<16 years), and 285 adults (≥16 years)

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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De Paepe, Katja, Lawrence Bonne, Nicos Fotiadis, et al. "Complications and seeding risk after percutaneous liver biopsy in an oncological setting." Journal of Clinical Oncology 36, no. 4_suppl (2018): 246. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.246.

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246 Background: Percutaneous biopsy of suspected liver metastases is a common practice for diagnostic purposes. Particularly, in the setting of oncological clinical trials, it is a relatively non-invasive method to obtain sufficient tissue for molecular analyses at regular set time points. However, various complications may occur, including seeding of the tumour along the biopsy tract. Only few reports exist on the actual incidence of seeding, on a limited number of tumor types. The aim of this study was to evaluate the technique’s safety and risk of seeding. Methods: All patients with an ultr

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Paroli, Marino, Andrea Becciolini, Alberto Lo Gullo, et al. "Influence of Safety Warnings on the Prescribing Attitude of JAK Inhibitors for Rheumatoid Arthritis in Italy." Journal of Clinical Medicine 13, no. 13 (2024): 3929. http://dx.doi.org/10.3390/jcm13133929.

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Background/Objectives: The Janus kinase inhibitors (JAKi) tofacitinib (TOFA), baricitinib (BARI), upadacitinib (UPA), and filgotinib (FILGO) are effective drugs for the treatment of rheumatoid arthritis. However, the US Food and Drug Administration (FDA) raised concerns about the safety of TOFA after its approval. This prompted the European Medicines Agency (EMA) to issue two safety warnings for limiting TOFA use, then extended a third warning to all JAKi in patients at high risk of developing serious adverse effects (SAE). These include thrombosis, major adverse cardiac events (MACE), and can

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Self, Wesley H., Matthew S. Shotwell, Kevin W. Gibbs, et al. "Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19." JAMA 329, no. 14 (2023): 1170. http://dx.doi.org/10.1001/jama.2023.3546.

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ImportancePreclinical models suggest dysregulation of the renin-angiotensin system (RAS) caused by SARS-CoV-2 infection may increase the relative activity of angiotensin II compared with angiotensin (1-7) and may be an important contributor to COVID-19 pathophysiology.ObjectiveTo evaluate the efficacy and safety of RAS modulation using 2 investigational RAS agents, TXA-127 (synthetic angiotensin [1-7]) and TRV-027 (an angiotensin II type 1 receptor–biased ligand), that are hypothesized to potentiate the action of angiotensin (1-7) and mitigate the action of the angiotensin II.Design, Setting,

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Suttorp, Meinolf, Ralf Knoefler, Hélène Deutsch, et al. "High Platelet Counts, Thrombosis, Bleeding Signs, and Acquired Von Willebrand Syndrome at Diagnosis of Pediatric Chronic Myeloid Leukemia." Blood 134, Supplement_1 (2019): 4152. http://dx.doi.org/10.1182/blood-2019-123343.

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Background: At diagnosis of chronic myeloid leukemia (CML) patients (pats) may present with elevated platelets (PLT) counts. Generally, high PLT counts may result in thrombosis and/or bleeding complications, the latter being due to binding of von Willebrand factor (VWF) multimers to platelets. Pediatric CML is very rare (Hijiya N, Suttorp M 2019; Blood 33:2374-2384) and no systematic investigation on clinical complications of elevated PLT counts has so far been reported. Methods: Data on PLT counts and associated thrombo-hemorrhagic complications were retrospectively analyzed in newly diagnose

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Schäfer, Stefan B., Claudia Rudolph, Martin Kolodziej, Frank Mauermann, Fritz Christian Roller, and Gabriele Anja Krombach. "Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 191, no. 11 (2019): 1015–25. http://dx.doi.org/10.1055/a-0881-3113.

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Purpose Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps. Materials and Methods In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. A visual assessment of the image quality was performed by two radiologists on the basi

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Zhan, Tianzuo, Thomas Hielscher, Asmé Bilge, et al. "Invitation letters increase participation in colorectal cancer screening – results from an observational study." Zeitschrift für Gastroenterologie 55, no. 12 (2017): 1307–12. http://dx.doi.org/10.1055/s-0043-121347.

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Abstract Background and Aim Participation rates in the German colorectal cancer screening program are low. Starting in 2013, a large health insurance plan in Bavaria, Germany, is sending an additional invitation letter to insured individuals when they turn 50 or 55 years and become eligible for participation in the program. The letter provides detailed information on colorectal cancer screening. We assessed the impact of the invitation letter on utilization rates. Methods Insurance claims data of a total of 48 343 individuals who had turned 50 or 55 years between 2012 to 2014 were reviewed for

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Goel, Ashish, Arsalan Moinuddin, Rajesh Tiwari, et al. "Effect of Smartphone Use on Sleep in Undergraduate Medical Students: A Cross-Sectional Study." Healthcare 11, no. 21 (2023): 2891. http://dx.doi.org/10.3390/healthcare11212891.

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Smartphone use, particularly at night, has been shown to provoke various circadian sleep–wake rhythm disorders such as insomnia and excessive daytime tiredness. This relationship has been mainly scrutinized among patient groups with higher rates of smartphone usage, particularly adolescents and children. However, it remains obscure how smartphone usage impacts sleep parameters in adults, especially undergraduate college students. This study sought to (1) investigate the association between smartphone use (actual screen time) and four sleep parameters: Pittsburgh sleep quality score (PSQI), sel

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Martini, Alberto, Claudia Kesch, Alae Touzani, et al. "Personalized Mobile App–Based Program for Preparation and Recovery After Radical Prostatectomy: Initial Evidence for Improved Outcomes From a Prospective Nonrandomized Study." Journal of Medical Internet Research 26 (December 13, 2024): e55429. https://doi.org/10.2196/55429.

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Background eHealth can help replicate the benefits of conventional surgical prehabilitation programs and overcome organizational constraints related to human resources and health care–related costs. Objective We aimed to assess the impact of an optimized perioperative program using a personalized mobile app designed for preparation and recovery after radical prostatectomy (RP). Methods We report on a series of 122 consecutive robot-assisted RP before and after the implementation of the betty.care app (cohort A: standard of care, n=60; cohort B: optimized program, n=62). The primary end point w

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Biswas, Sourav, Zeba Khanam, Asraful Alam, and Lakshminarayan Satpati. "Progress and determinants of household access to improved drinking water in India using a Water Access Index: insights from the National Family Health Survey towards achieving SDG 6.1." BMJ Open 15, no. 6 (2025): e091269. https://doi.org/10.1136/bmjopen-2024-091269.

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Background and objectiveAccess to clean drinking water is essential for health and development. Despite global and national initiatives, many regions in India continue to face inadequate water access. This study assesses progress, sociodemographic determinants and geographic disparities in access to drinking water in India, aligning with Sustainable Development Goal (SDG) 6.1.DesignThis study used secondary data from five rounds of the National Family Health Survey (NFHS-1 to NFHS-5; 1992–2021), nationally representative surveys conducted across India. Logistic regression was employed to exami

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Chen, H. M., Z. A. Li, X. F. Wang, et al. "First Report of Citrus yellow vein clearing virus on Lemon in Yunnan, China." Plant Disease 98, no. 12 (2014): 1747. http://dx.doi.org/10.1094/pdis-04-14-0343-pdn.

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Eureka lemon (Citrus limon) is an economically important crop in China. In 2009, a new disease was observed on Eureka lemon in an orchard of Ruili city in Yunnan Province. Nearly 10% of the plants were symptomatic with yellow vein clearing on lateral veins, combined with leaf crinkling and warping of young leaves. Water-soaked appearances were also seen on the adaxial leaf veins. The symptoms were present on mature leaves, resulting in almost 20% yield reduction. The symptoms on leaves were more severe in spring and autumn than in summer. This disease was transmitted by grafting from infected

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Carrenho-Sala, L. C., R. V. Sala, M. Fosado, et al. "107 FACTORS THAT INFLUENCE FERTILITY IN AN IVF EMBRYO TRANSFER PROGRAM IN DAIRY HEIFERS." Reproduction, Fertility and Development 28, no. 2 (2016): 183. http://dx.doi.org/10.1071/rdv28n2ab107.

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A retrospective study was performed to evaluate factors that influence pregnancy per embryo transfer (P/ET) in an IVF-embryo transfer program. A total of 5026 fresh in vitro-produced embryos were transferred during 2014 and evaluated for effects of embryo quality, embryo stage, size of corpus luteum (CL; 18–19.9 mm or ≥20 mm), interval from GnRH to embryo transfer, number of previous embryo transfer (0, 1, 2, 3, ≥4); and interaction of embryo stage and interval from GnRH to embryo transfer. One group (n = 850) had detection of oestrus after prostaglandin F2α application but most heifers (n = 4

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Lofters, W. S., J. L. Pater, B. Zee, et al. "Phase III double-blind comparison of dolasetron mesylate and ondansetron and an evaluation of the additive role of dexamethasone in the prevention of acute and delayed nausea and vomiting due to moderately emetogenic chemotherapy." Journal of Clinical Oncology 15, no. 8 (1997): 2966–73. http://dx.doi.org/10.1200/jco.1997.15.8.2966.

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PURPOSE To compare the efficacy of dolasetron and ondansetron in controlling nausea and vomiting in the first 24 hours; to evaluate the efficacy when dexamethasone is added to either drug in the first 24 hours; and to extend these comparisons over 7 days in patients receiving moderately emetogenic chemotherapy. PATIENTS AND METHODS This was a multicenter, double-blind, randomized study with six parallel arms that used a 2 x 2 factorial design in chemotherapy-naive patients. In arm 1, dolasetron (2.4 mg/kg) was given intravenously (I.V.) prechemotherapy, followed 24 hours later by oral dolasetr

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M, Splonskowski, Smith S, and Jacova C. "A-025 Subjective Cognitive Decline and Likelihood of Participation Across Home-Based Cognitive Assessment Modalities." Archives of Clinical Neuropsychology 35, no. 6 (2020): 815. http://dx.doi.org/10.1093/arclin/acaa068.025.

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Abstract Objective Individuals with subjective cognitive decline (SCD) are approximately twice as likely to develop dementia and less likely to seek cognitive assessment. Home-based cognitive assessment (HBCA) could reduce many practical and emotional barriers associated with in-person cognitive testing. We aimed to explore the relationship between SCD and likelihood of HBCA participation across various modalities. Method A nation-wide sample of 483 community-dwelling adults age 50 years and older (M = 63.61 ± 5.47) were recruited via Amazon Mechanical Turk, an online crowdsourcing website, to

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Rodríguez Salas, G., A. M. Santos, V. Navarro-Compán, et al. "AB1023 THE DIFFERENTIAL CHARACTERISTIC OF SPONDYLOARTHRITIS PATIENTS WHO CANNOT BE CLASSIFIED ACCORDING TO ASAS: RESULTS FROM THE GESPA COLOMBIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1733.2–1734. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5271.

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BackgroundThe Assessment of SpondyloArthritis International Society (ASAS) classification criteria for SpA has changed the approach to the disease, enhancing the performance of the classification process. However, regardless of the ASAS classification criteria were developed according to a global cohort of patients, Latin American patients were not included in a significant number. SpA patients from our region have unique characteristics that may impact the SpA classification. Other alleles than HLA-B27 have been identified, the frequency of HLA-B15 was reported to be 19.1% in the Latin Americ

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Powell, Danielle, Wuyang Zhang, and Nicholas Reed. "EFFECT OF AWARENESS OF HEARING LOSS AMONG CARE RECIPIENTS ON ATTRIBUTES OF CARE PROVIDED: A NATIONAL STUDY." Innovation in Aging 8, Supplement_1 (2024): 778. https://doi.org/10.1093/geroni/igae098.2529.

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Abstract Hearing loss (HL) is prevalent among older adults and may result in caregiving challenges due to communication barriers. This study aims to investigate whether care recipients’ awareness of HL is associated with attributes of care. Using data from Round 12 (2022) of the linked National Health and Aging Trends Study (NHATS) and National Study on Caregiving (NSOC), a sample of 1,133 (Mean age: 62±15 years; Female: 68%) caregivers assisting 713 older adults (Mean age: 83±8 years; Female: 63%; White: 63%) with audiometric HL was derived. From care recipients’ self-reported hearing difficu

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Farkas, B., M. Borsos, T. Resál, et al. "P1016 Real-world data on sequential therapy in moderate-to-severe UC: Unveiling second-line strategies after anti-TNF failure." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1837—i1838. http://dx.doi.org/10.1093/ecco-jcc/jjad212.1146.

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Abstract Background The development of anti-TNFs has brought major advances in the treatment of ulcerative colitis (UC). Yet, a significant proportion of patients do not respond favorably to first-line anti-TNF therapy, which may require the use of second-, third-, or fourth-line biologics or small molecules. Treatment selection and sequencing, however, remains a major unmet need. Methods We conducted a multicenter, retrospective study including patients with moderate-to-severe UC who failed first-line anti-TNFs, and received sequential therapy with biologics or small-molecules. The effectiven

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Weiden, Peter J., Keisha Novak, Carolyn Watson, et al. "Pooled Analysis of EPS-Like Symptoms in the EMERGENT Program of KarXT in Schizophrenia." CNS Spectrums 29, no. 5 (2024): 509. https://doi.org/10.1017/s1092852924001792.

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IntroductionAlthough atypical antipsychotics have lowered the prevalence and severity of extrapyramidal symptoms (EPS), they still contribute to the overall side-effect burden of approved antipsychotics. Drugs with novel mechanisms without D2 dopamine receptor blocking activity have shown promise in treating schizophrenia without the side effects of currently available treatments. KarXT (xanomeline–trospium chloride) represents a possible alternative that targets muscarinic receptors. KarXT demonstrated efficacy compared with placebo in 3 out of 3 short-term acute studies and has not been asso

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Medas, Fabio, Chiara Dobrinja, Suhami Ebtesam Abdulah Al, et al. "Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study." Lancet Diabetes and Endocrinology 11, no. 6 (2023): 402–13. https://doi.org/10.1016/S2213-8587(23)00094-3.

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Abstract <strong>Background: </strong>Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. <strong>Methods: </strong>In this retrospective, international, cross-sectional study,

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Krasikovs, A., and V. Ozola. "Synthesis of 1-Methoxy-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one." Chemistry of Heterocyclic Compounds 49, no. 3 (2013): 496–99. http://dx.doi.org/10.1007/s10593-013-1274-5.

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Puttagunta, A. L., C. L. Chik, M. Girard, L. O'Brien, and A. K. Ho. "Intracellular pH and growth hormone-releasing factor-stimulated adenosine 3′5′-monophosphate, intracellular calcium and growth hormone release from rat anterior pituitary cells." Journal of Endocrinology 135, no. 2 (1992): 343–52. http://dx.doi.org/10.1677/joe.0.1350343.

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ABSTRACT In this study, we examined the effect of changes in intracellular pH (pHi) on basal and GH-releasing factor (GRF)-stimulated cyclic AMP (cAMP), intracellular Ca2+ and GH release using a static monolayer culture prepared from dispersed rat anterior pituitary cells. To modulate pHi, two approaches were used: variation of extracellular pH (pHo) and addition of sodium propionate and ammonium chloride which alter pHi directly. Direct pHi measurement with 2′7′-bis(carboxyethyl)-5(6)-carboxyfluorescein showed that for pHo values between 6·9 and 7·6, a change in pHo of 0·1 units resulted in a

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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