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Journal articles on the topic '343.3/.7. 343.4(043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Uslu Yurteri, E., M. E. Yayla, B. Atmaca Haktaniyan, et al. "AB1462 EFFECTIVENESS OF THE STILL ACTIVITY SCORE IN ADULT-ONSET STILL’S DISEASE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1959.1–1959. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3959.

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BackgroundAdults Still’s disease is a rare autoinflammatory disorder with an unknown etiology, characterized by fever, arthritis, and rash. There is no method to fully evaluate the disease’s activity [1].ObjectivesThe Still Activity Score (SAS) is a newly defined, easy-to-use disease activity assessment score for Still disease [2]. We aimed to compare the efficacy of the Modified Pouchot Activity Score (mPouchot), Systemic Feature Score (SFS), and Still Activity Score (SAS) [2-4].MethodsThe study included 45 patients diagnosed with Still between 2010 and 2022 who met the Yamaguchi criteria. Th

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Medas, Fabio, Chiara Dobrinja, Suhami Ebtesam Abdulah Al, et al. "Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study." Lancet Diabetes and Endocrinology 11, no. 6 (2023): 402–13. https://doi.org/10.1016/S2213-8587(23)00094-3.

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Abstract <strong>Background: </strong>Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. <strong>Methods: </strong>In this retrospective, international, cross-sectional study,

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Lofters, W. S., J. L. Pater, B. Zee, et al. "Phase III double-blind comparison of dolasetron mesylate and ondansetron and an evaluation of the additive role of dexamethasone in the prevention of acute and delayed nausea and vomiting due to moderately emetogenic chemotherapy." Journal of Clinical Oncology 15, no. 8 (1997): 2966–73. http://dx.doi.org/10.1200/jco.1997.15.8.2966.

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PURPOSE To compare the efficacy of dolasetron and ondansetron in controlling nausea and vomiting in the first 24 hours; to evaluate the efficacy when dexamethasone is added to either drug in the first 24 hours; and to extend these comparisons over 7 days in patients receiving moderately emetogenic chemotherapy. PATIENTS AND METHODS This was a multicenter, double-blind, randomized study with six parallel arms that used a 2 x 2 factorial design in chemotherapy-naive patients. In arm 1, dolasetron (2.4 mg/kg) was given intravenously (I.V.) prechemotherapy, followed 24 hours later by oral dolasetr

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Carrenho-Sala, L. C., R. V. Sala, M. Fosado, et al. "107 FACTORS THAT INFLUENCE FERTILITY IN AN IVF EMBRYO TRANSFER PROGRAM IN DAIRY HEIFERS." Reproduction, Fertility and Development 28, no. 2 (2016): 183. http://dx.doi.org/10.1071/rdv28n2ab107.

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A retrospective study was performed to evaluate factors that influence pregnancy per embryo transfer (P/ET) in an IVF-embryo transfer program. A total of 5026 fresh in vitro-produced embryos were transferred during 2014 and evaluated for effects of embryo quality, embryo stage, size of corpus luteum (CL; 18–19.9 mm or ≥20 mm), interval from GnRH to embryo transfer, number of previous embryo transfer (0, 1, 2, 3, ≥4); and interaction of embryo stage and interval from GnRH to embryo transfer. One group (n = 850) had detection of oestrus after prostaglandin F2α application but most heifers (n = 4

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Luu, Huong, Gerald Spotts, Hartwig Gajek, et al. "ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin- Free Method] Post-Authorization Safety Surveillance (PASS): Safety and Efficacy Following Product Switch in Routine Clinical Practice." Blood 112, no. 11 (2008): 3375. http://dx.doi.org/10.1182/blood.v112.11.3375.3375.

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Abstract A prospective, non-interventional Post-Authorization Safety Surveillance (PASS) program was initiated in 2004 to document ADVATE safety and efficacy in routine clinical practice. More than 900 subjects newly prescribed ADVATE have been enrolled in the US, EU and Japan alone. Herein, we present final US and interim EU results comprising 506 treated subjects, 451 of which have completed the 1-year observation period and 20 ongoing. Age cohorts were as follows: 27 neonates/infants (0-<2 years), 128 children (2-<12 years), 54 adolescents (12-<16 years), and 285 adults (≥16 years)

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Hajlaoui, Sondes, Iskandar Chaabane, and Kamel Guidara. "Conduction mechanism model, impedance spectroscopic investigation and modulus behavior of the organic–inorganic [(C3H7)4N][SnCl5(H2O)]·2H2O compound." RSC Advances 6, no. 94 (2016): 91649–57. http://dx.doi.org/10.1039/c6ra16679b.

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In this study, the electric properties and modulus formulation of the compound [(C<sub>3</sub>H<sub>7</sub>)<sub>4</sub>N][SnCl<sub>5</sub>(H<sub>2</sub>O)]·2H<sub>2</sub>O were studied in the 200 Hz to 5 MHz frequency range and the 343–418 K temperature range.

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Lüftner, Diana, Cosima Brucker, Thomas Decker, et al. "Abstract P1-18-15: Real-world efficacy of ribociclib + aromatase inhibitor/fulvestrant, or endocrine monotherapy, or chemotherapy as first-line treatment in women with hormone receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) locally advanced or metastatic breast cancer: Fourth interim analysis from the RIBANNA study." Cancer Research 82, no. 4_Supplement (2022): P1–18–15—P1–18–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-18-15.

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Abstract Background: Ribociclib (RIB; a selective CDK4/6 inhibitor) + endocrine therapy (ET; aromatase inhibitor or fulvestrant along with ovarian suppression in pre- and perimenopausal patients [pts]) received USFDA and EMA approval for pre-, peri- and postmenopausal pts with HR+, HER2- advanced breast cancer (ABC) based on results from phase 3 MONALEESA (ML) trials. In ML-2 trial, first-line treatment (tx) with RIB + letrozole (LET) vs placebo (PBO) + LET significantly improved median progression-free survival (mPFS) in postmenopausal pts with HR+, HER2- ABC. In ML-3 and ML-7 trials, RIB + E

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Hurwitz, Herbert, Eric Van Cutsem, Johanna C. Bendell, et al. "Two randomized, placebo-controlled phase 3 studies of ruxolitinib (Rux) + capecitabine (C) in patients (pts) with advanced/metastatic pancreatic cancer (mPC) after failure/intolerance of first-line chemotherapy: JANUS 1 (J1) and JANUS 2 (J2)." Journal of Clinical Oncology 35, no. 4_suppl (2017): 343. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.343.

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343 Background: The JAK-STAT pathway plays a role in the pathogenesis of PC. In a phase 2 study, the JAK1/2 inhibitor Rux + C improved OS vs C alone in mPC pts with evidence of systemic inflammation. Methods: In two phase 3 studies, advanced/mPC pts with only 1 prior chemotherapy regimen and C-reactive protein > 10mg/L were randomized to 21-day cycles of Rux 15 mg BID + C 2000 mg/m2/d (day 1-14) vs placebo (Pb) BID + C 2000 mg/m2/d (day 1-14). The primary endpoint was OS. The studies were terminated early based on efficacy findings of a planned interim analysis for J1, with J2 enrollment in

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Williams, Gary L. "343 Preparing a quality animal care and use protocol." Journal of Animal Science 98, Supplement_4 (2020): 72–73. http://dx.doi.org/10.1093/jas/skaa278.132.

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Abstract Objectives in preparing a quality animal care and use protocol (AUP) revolve around the creation of a document that meets federal and institutional regulatory guidelines and that provides adequate detail for members of the institutional animal care and use committee to determine whether animal care and use procedures are justified and humane. Generally, either the Public Health Service Policy on Humane Care and Use of Laboratory Animals or Guide for the Care and Use of Agricultural Animals in Research and Teaching will serve as a guide for preparing AUPs. In addition, AUPs are publicl

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Kaburagi, Taeko, Genki Yamato, Norio Shiba, et al. "Recurrent Gene Mutations in Pediatric Patients with AML By Targeted Sequencing ―the Jccg Study, JPLSG AML-05―." Blood 134, Supplement_1 (2019): 2697. http://dx.doi.org/10.1182/blood-2019-126545.

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Introduction Treatment outcomes of pediatric acute myeloid leukemia (AML) have improved via stratification therapy. However, relapse and mortality are still observed in 40% and 30% patients, respectively. Recently, comprehensive analyses using next-generation sequencing have revealed novel genetic alterations in adult AML patients, but insufficient analyses have been performed in pediatric AML patients. Further studies are warranted to evaluate the relationship between a more detailed genetic background and prognosis in pediatric AML patients. Methods We performed targeted sequencing using a 3

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Baspinar, S. N., M. B. Yuzbasioglu, S. Yenigun, F. N. Azman, and S. Ugurlu. "AB1466 CLINICAL FEATURES OF PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER OVER 50 YEARS OF AGE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1961.2–1962. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4801.

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BackgroundFamilial Mediterranean Fever (FMF) is the most common hereditary monogenic fever syndrome characterized by recurrent attacks of fever and polyserositis. Types and frquencies of attacks can change throughout the life of patients. The course of disease is affected by pathophysiological changes due to aging, increased comorbid diseases and multiple drug use.ObjectivesThe objective of this study was to understand the effect of aging on clinical features and disease course in patients with Familial Mediterranean Fever.Methods343 patients who were followed up with the diagnosis of FMF betw

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Neuzillet, Cindy, Jean-François Seitz, Laetitia Fartoux, et al. "Sunitinib as second-line treatment in patients with advanced intrahepatic cholangiocarcinoma (SUN-CK phase II trial): Safety, efficacy, and updated translational results." Journal of Clinical Oncology 33, no. 3_suppl (2015): 343. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.343.

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343 Background: There is no validated option beyond gemcitabine plus platinum standard first-line combination for advanced cholangiocarcinoma (CK). Second-line 5FU-based chemotherapy yields a median progression-free survival (PFS) and overall survival (OS) of 3 and 6-7 months, respectively. Intrahepatic CK subtypes overexpress VEGF, providing a rationale for testing sunitinib as second-line treatment in patients (pts) with advanced intrahepatic CK. Methods: A multicenter phase 2 study was designed for pts with locally advanced or metastatic intrahepatic CK after failure of first-line gemcitabi

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Shore, Neal D., Luke T. Nordquist, Shilpa Gupta, et al. "Once-nightly (QD) dual CYP17-Lyase (L) inhibitor / androgen receptor (AR) antagonist VT-464 in patients with CRPC." Journal of Clinical Oncology 34, no. 2_suppl (2016): 343. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.343.

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343 Background: VT-464 is an oral, CYP17-L inhibitor and non-clinically an antagonist of the AR and its variants associated with clinical resistance to enzalutamide (ENZ) and abiraterone (AA). The safety, tolerability and initial PD effects (tumor responses, PSA and testosterone (T)-decreases) of QD VT-464 were evaluated in this Phase (Ph) 1/2 study (INO-VT-464-CL-004; NCT02361086). Methods: Chemotherapy-naïve (n = 20) M0 (n = 1) and M1 (n = 19) patients with CRPC prior to (TN, treatment-naïve; n = 9), or after AA (n = 6),ENZ (n = 3) or both (n = 2) were enrolled in sequential dose-cohorts of

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Guo, Yong En, Xiao Guang Niu, Cai Ju Zhou, Jie Chu, Wei Wei Xu, and Guo Zhen Fang. "Design and Preparation of 1H-3, 4-Dihydropyrrolo[1,2-a] Pyrazin-1-One via 1H-3,4-Dihydropyrrolo[1,2-C] [1,4] Oxazin-1-One Route." Advanced Materials Research 343-344 (September 2011): 1242–47. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.1242.

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With 2-pyrrolyltrichloroacetone as major starting material, unreported 1H-3,4-dihydropyrrolo- [1,2-a]pyrazin-1-one was prepared successively by its monoesterification with ethylene glycol, bromine displacement of hydroxy group, cyclization to lactone and its amidation. Unreported 7-aroyl-1H-3,4-dihydropyrrolo[1,2-c][1,4]oxazin-1-one compounds were also synthesized in turn by 2-pyrrolyl-trichloroacetone’s Friedel-Crafts acylation and cyclization. Their structures were characterized by IR, 1H NMR, 13C NMR, MS, HRMS, etc.

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Kennedy, Andrew S., Maha Elkordy, Elizabeth Estill Campbell, Brent Albertson, Scott Lee Sailer, and Margaret Ann Deutsch. "90Y radioembolization for neuroendocrine cancers liver metastases provides sustained therapeutic effect with minimal toxicity." Journal of Clinical Oncology 30, no. 4_suppl (2012): 343. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.343.

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343 Background: Radioembolization (RE) is the delivery of radioactive microspheres (90Y) via the hepatic artery, which permanently implant preferentially in metastatic lesions, sparing adjacent normal liver. Metastatic neuroendocrine tumors in the liver are a common clinical problem which can be treated with RE. It is an outpatient procedure performed with increasing frequency worldwide for a variety of solid tumor types. Methods: A single institution retrospective review of all neuroendocrine patients treated with radioactive resin microspheres to control hepatic metastases. Details reviewed

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Chida, Natasha, Christopher Brown, Jyoti Mathad, et al. "Developing an Assessment Framework for Essential Internal Medicine Subspecialty Topics." Journal of Graduate Medical Education 10, no. 3 (2018): 331–35. http://dx.doi.org/10.4300/jgme-d-17-00377.1.

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ABSTRACT Background Assessing residents by direct observation is the preferred assessment method for infrequently encountered subspecialty topics, but this is logistically challenging. Objective We developed an assessment framework for internal medicine (IM) residents in subspecialty topics, using tuberculosis diagnosis for proof of concept. Methods We used a 4-step process at 8 academic medical centers that entailed (1) creating a 10-item knowledge assessment tool; (2) pilot testing on a sample of 129 IM residents and infectious disease fellow volunteers to evaluate validity evidence; (3) imp

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Nakai, Ryuichiro, Ayaka makino, Hitomi Hama, et al. "1066. In Vitro and in Vivo Antimicrobial Activity of Cefiderocol and Comparators against Achromobacter spp." Open Forum Infectious Diseases 8, Supplement_1 (2021): S625—S626. http://dx.doi.org/10.1093/ofid/ofab466.1260.

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Abstract Background Achromobacter spp. is intrinsically resistant to multiple antibiotics, and the treatment options are limited. Cefiderocol (CFDC), a siderophore cephalosporin approved in US and EU, is active against a wide variety of aerobic Gram-negative bacteria, including carbapenem-resistant strains. In this study, in vitro and in vivo antibacterial activity of CFDC against Achromobacter spp. was evaluated. Methods A total of 334 global isolates collected by IHMA from 39 countries in 2015-2019 were used. Minimum inhibitory concentrations (MICs) of CFDC and comparators were determined by

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Lucas, C., S. Rodriguez, R. Jean, et al. "AB0034 EARLY IMMUNIZATION AGAINST TREATMENT IS ASSOCIATED TO POOR CLINICAL RESPONSE AT 6 MONTHS AND LOW NUMBER OF TRANSITIONAL B CELLS AT BASELINE IN RHEUMATOID ARTHRITIS PATIENTS TREATED BY ADALIMUMAB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1319.1–1320. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3938.

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Background:Circulating anti-drug antibodies (ADAs) are detectable approximatively in 33% of adalimumab treated rheumatoid arthritis (RA) patients, often within the first 6 months of therapy1-2. Classically, circulating ADAs associate with their specific drugs to form immune complexes, increasing drug clearance, and by this mechanism reducing therapeutic effect3. B cell involvement leading to ADAs production is not yet well established.Objectives:To study early ADAs formation according to clinical response to an adalimumab therapy in RA patients and the relationship between ADAs and circulating

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Schlack, Katrin, Andres Jan Schrader, Laura-Maria Krabbe, Karoline Kannen, Axel Semjonow, and Martin Boegemann. "Prediction of outcome in bone metastatic, castration-resistant prostate-cancer-patients under enzalutamide by combining biomarkers." Journal of Clinical Oncology 36, no. 6_suppl (2018): 334. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.334.

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334 Background: Under early Enzalutamide (Enza) treatment of bone mCRPC (bmCRPC), prostate-specific antigen (PSA) might be misleading, since a PSA-flare may occur. Bouncing of alkaline phosphatase (APB) was shown as a promising surrogate for survival outcome. Low lactate dehydrogenase (LDH) usually predicts better outcome. The purpose of this study was to evaluate the prognostic ability of APB, LDH, PSA and information of the pooled markers after initiation of Enza. Methods: 89 bmCRPC-patients were analyzed. PSA, LDH and AP were monitored at 2, 4, 8, 12 and 20 weeks. APB was defined as an incr

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Zhang, Li Ping, Jie Pang, Lei Ke, et al. "SPSS for Water Pollution Contribution of Tonghui River in Beijing Based on Principal Component Analysis." Advanced Materials Research 343-344 (September 2011): 483–89. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.483.

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This paper researches on sewage discharge condition along Tonghui River in Beijing. According to stationing principle and field investigation, there are 18 sewage outlets along Tonghui River and select 7 main water quality pollution indicators and sewage flow to assess the sewage outlets’ pollution distribution. By means of SPSS soft applied in principal component analysis method, paper analysis on the main pollution indicators and the main pollution contribution sewage outlets. The result shows 3 extracted principal components reflect 88.92% information of primitive variables. Then solve the

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Purbowati, I. S. M., Karseno Karseno, and A. Maksum. "Acidity level control formulation of roselle tea functional drinks based on variations in the addition of flower petals and sugar type." Food Research 4, no. 3 (2020): 772–79. http://dx.doi.org/10.26656/fr.2017.4(3).343.

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Roselle (Hibiscus sabdariffa) tea was a phenolic acid and anthocyanin enriched-functional drink. The high antioxidant content of roselle tea benefits to prevent degenerative diseases, such as diabetes. The acidity flavor was due to the high content of phenolic compounds and anthocyanins. This led to the addition of low glycemic index sugar. Therefore, it is necessary to understand the formulation between the variation of flower petals and sugar type’s addition. The purpose of this study was to find out the best effect of petal flowers and sugar type addition towards physical, chemical and sens

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Feunaing, Romeo Toko, Alfred Ngenge Tamfu, Abel Joel Yaya Gbaweng, et al. "In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)." Molecules 29, no. 11 (2024): 2456. http://dx.doi.org/10.3390/molecules29112456.

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Alzheimer’s disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are suitable therapies for AD, while α-amylase and α-glucosidase inhibitors are employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera and evaluated for their AChE, BChE, α-amylase, and α-glucosidase inhibitions. From 1H and 13C NMR data, the compounds were identified as 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-xylopyranoside (2), 3,3′,4′-tri-O-meth

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Li, Qingyang, Xiaohu Yang, Chengze Liu, et al. "Groups and Protocluster Candidates in the CLAUDS and HSC-SSP Joint Deep Surveys." Astrophysical Journal 933, no. 1 (2022): 9. http://dx.doi.org/10.3847/1538-4357/ac6e69.

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Abstract Using the extended halo-based group finder developed by Yang et al., which is able to deal with galaxies via spectroscopic and photometric redshifts simultaneously, we construct galaxy group and candidate protocluster catalogs in a wide redshift range (0 < z < 6) from the joint CFHT Large Area U-band Deep Survey and Hyper Suprime-Cam Subaru Strategic Program deep data set. Based on a selection of 5,607,052 galaxies with i-band magnitude m i < 26 and a sky coverage of 34.41 deg2, we identify a total of 2,232,134 groups, of which 402,947 groups have at least three member galaxi

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Ku, Geoffrey Yuyat, Jennifer Moughan, Terence Marques Williams, et al. "Initial safety assessment of the endoscopically injected oncolytic virus OBP-301 in medically inoperable esophageal cancer: NRG-GI007." Journal of Clinical Oncology 42, no. 3_suppl (2024): 341. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.341.

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341 Background: Definitive chemoradiation (CRT) is a standard-of-care for patients (Pts) with medically inoperable esophageal cancer (EC). The NRG/RTOG 0436 study of cisplatin/paclitaxel and RT (+/- cetuximab) as definitive therapy showed that about half of Pts have locally persistent disease. OBP-301 is a conditionally restricted, replication-competent adenovirus derived from human adenovirus type 5 that adds a human Telomerase Reverse Transcriptase (hTERT) gene promoter, replicating only in tumor cells to cause lysis. It may cause immunogenic cell death, enhance RT, and improve local control

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Andrejić, Živojin. "CRKVENI ŠEMATIZAM BEOGRADSKO-SREMSKE EPARHIJE -NAHIJE BEOGRAD, ŽELEZNIK, AVALA I ZEMUN – U XVI VEKU PREMA TURSKIM KATASTARSKIM POPISIMA." Šumadijski anali 18, no. 12 (2022): 64–88. http://dx.doi.org/10.46793/sanali18.12.064a.

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According to the census from 1528-1530, Železnik had 625 households with about 4,500 residents. Belgrade nahia had 2413 households with about 17,000 inhabitants, 22000 in total with the city of Belgrade. Nahia Zemun, in 1546, had 343 households with about 2400 inhabitants. In the middle of the 16th century, in 246 villages and 4 towns, the Belgrade Eparchy had 34 churches, 38 priests, and 7 monasteries in four nahias. There are 4 permanent and weekly squares, and a total of 40 mezras and 49 mills. Nahia Zemun does not have them on the list. The city of Belgrade in 1536 had 79 Muslim homes, 4 m

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Korb, R. E., M. J. Whitehouse, M. Gordon, P. Ward, and A. J. Poulton. "Summer microplankton community structure across the Scotia Sea: implications for biological carbon export." Biogeosciences 7, no. 1 (2010): 343–56. http://dx.doi.org/10.5194/bg-7-343-2010.

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Abstract. During the austral summer of 2008, we carried out a high resolution survey of the microplankton communities along a south to north transect covering a range of environments across the Scotia Sea, Southern Ocean; high and low productivity, sea-ice to open water conditions, and over a number of oceanographic fronts and bathymetric features. Cluster analysis revealed five distinct communities that were geographically constrained by physical features of bathymetry and fronts. From south to north the communities were: (1) the South Orkney group, a mixed community of naked dinoflagellates

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Wei, J. Y., D. Mendelowitz, N. Anastasi, and J. W. Rowe. "Maintenance of carotid baroreflex function in advanced age in the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 250, no. 6 (1986): R1047—R1051. http://dx.doi.org/10.1152/ajpregu.1986.250.6.r1047.

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To evaluate the influence of age per se on the carotid sinus baroreceptors in the absence of hypertension and atherosclerosis, we employed the Fischer 344 rat model. In 14 adult (A, 6-9 mo) and 9 senescent (S, 24-26 mo) normotensive male Fischer 344 rats the left carotid sinus region was vascularly isolated with sinus nerve intact and perfused with oxygenated modified Kreb's solution. Simultaneous measurements of intrasinus pressure and femoral arterial pressure response were obtained during linear pressure increases (20-200 mmHg) in the vascularly isolated sinus. There was no age difference i

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Раимкулов, К. М., В. С. Тойгомбаева, О. Т. Куттубаев та А. Э. Мергенов. "КЫРГЫЗ РЕСПУБЛИКАСЫНЫН ОШ ОБЛУСУНУН КАЛКЫНЫН АРАСЫНДА ЭХИНОКОККОЗ ООРУЛАРЫ МЕНЕН ЖАБЫРКАШЫНА ЖАНА ЖҮРҮМ-ТУРУМ ТОБОКЕЛДИК ФАКТОРЛОРУНА БАА БЕРҮҮ". Euroasian Health Journal, № 1 (29 березня 2024): 137–45. http://dx.doi.org/10.54890/ehj-2024-1-137.

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В статье рассмотрены результаты ультразвукового исследования (УЗИ), иммуноферментного анализа (ИФА), исследования на наличие специфических антител, результаты опроса населения 7 районов (8823 человек) и оценки поведенческого фактора риска заражения эхинококкозами населения Ошской области Кыргызской Республики (КР). По результатам ИФА получено 12,0 ± 0,3% (1060) положительных, на УЗИ 8,0 ±0,4% (703). Чаще выявлялась инвазия альвеококкозом как на УЗИ, так на ИФА – 334 (3,78%) и 74,3 ± 0,4% (788) соответственно. Самым эндемичным районом оказался Алайский, где инвазированность обследованных лиц со

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Dercle, Laurent, Susan Michelle Geyer, Andrew B. Nixon, et al. "Radiomic signatures to predict survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib +/- doxorubicin: Correlative science from CALGB 80802 (Alliance)." Journal of Clinical Oncology 39, no. 3_suppl (2021): 343. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.343.

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343 Background: Alliance/CALGB 80802, a randomized phase III trial, evaluated sorafenib plus doxorubicin vs. doxorubicin in pts with HCC and showed no improvement in median overall survival (OS) (HR[95CI] 1.05[0.83-1.31]) or PFS (HR[95CI] 0.93[0.75-1.16]). In HCC surrogacy of tumor response with OS remains controversial, in part due to varying criteria used for response evaluation (e.g., RECIST1.1 and mRECIST). We evaluated the performance of several models to predict OS using pretreatment clinical and radiomic variables. Methods: In CALBG 80802, we segmented all measurable tumor lesions on se

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Nurani, Yuliani, Niken Pratiwi, Robinson Situmorang, and Ni Gusti Ayu Made Yeni Lestari. "Children’s Character Learning Model Based on Indonesian Local Wisdom: Implemented to Early Childhood Education in Play Centers." JPUD - Jurnal Pendidikan Usia Dini 18, no. 1 (2024): 99–111. http://dx.doi.org/10.21009/jpud.181.07.

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Character education can equip young children to become Indonesia's golden generation who are superior and skilled in noble work. This research aims to produce an early childhood character learning model based on local Indonesian wisdom through the Playing Center title which will be implemented at Early Childhood Education Institutions (ECE) in Indonesia. This research method uses the steps of the Borg and Gall research and development model. The subjects in this research were 30 teachers from five ECE institutions in the DKI Jakarta area. The data used as the basis for building a framework for

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Bowmaker, Graham A., Effendy, Robert D. Hart, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXIII Synthesis, Spectroscopy and Structural Systematics of New 1 : 1 'Cubane' Tetramers of Copper(I) and Silver(I) Halides with Triphenylarsine." Australian Journal of Chemistry 50, no. 6 (1997): 653. http://dx.doi.org/10.1071/c96039.

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Syntheses and room-temperature single-crystal X-ray structural characterization of a number of 1 : 1 ‘cube tetramer’ adducts of copper(I) and silver(I) halides, MX, with triphenylarsine, AsPh3, are recorded, being [XM(AsPh3)]4. The CuBr adduct, obtained unsolvated from toluene, orthorhombic Pbcn, a 17·844(5), b 20·778(8), c 18·430(4) Å, Z = 4 tetramers, conventional R on |F| 0·058 for No 1309 independent ‘observed’ reflctions (I > 3σ(I)), is isomorphous with previously recorded [ClAg(PPh3)]4, the tetramer having crystallographically imposed 2 symmetry. The CuI adduct, previously recorded as

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Matei, Daniela, Virginia L. Filiaci, Marcus Randall, et al. "A randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel vs. carboplatin and paclitaxel for optimally debulked, advanced endometrial carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5505. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5505.

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5505 Background: Patients with stage III/IVA uterine cancer (UC) carry high risk of systemic and local recurrence. Chemotherapy was shown to reduce systemic recurrence, however the risk of local failure remains high. Methods: The primary endpoint of this open label, randomized phase III trial was to determine if treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for 4 cycles (C-RT, experimental arm) reduces the rate of recurrence or death (i.e., increases recurrence-free survival, RFS) when compared to carboplatin and paclitaxel for 6 cycles (CT, cont

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Kurtut, M. Y., C. L. Tawah, J. E. O. Rege, Nega-Alemayehu, and Mesfin-Shibre. "Lactation performance of purebred Arsi cows and Friesian × Arsi crosses under pre-partum and post-partum supplementary feeding regimes." Animal Science 68, no. 4 (1999): 625–33. http://dx.doi.org/10.1017/s1357729800050657.

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AbstractA study was conducted at the Asella Station in the Arsi Region of Ethiopia to investigate the dairy performance of indigenous purebred Arsi and Friesian × Arsi crosses under different pre-partum and post-partum supplementary feeding regimes. A total of’343 first-lactation animals were involved in the experiment. Lactation performance was not significantly affected by pre-partum supplementation. Post-partum supplementary feeding significantly affected total lactation milk and butterfat yields of the crosses but not the purebred Arsi. Arsi crosses produced more milk (1873 (s.e. 65·1) v.

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Reyes, E. A., D. R. Bergfelt, V. F. Ratto, X. P. Valderrama, E. Arcelay, and M. H. Ratto. "122 OVARIAN FOLLICULAR DYNAMICS IN CROSS-BRED EWES DURING THE RAINY SEASON UNDER TROPICAL CONDITIONS." Reproduction, Fertility and Development 29, no. 1 (2017): 169. http://dx.doi.org/10.1071/rdv29n1ab122.

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Small ruminants are an important livestock species on many island nations of the Eastern Caribbean region and serve as a vital source of food and income. This study was designed to characterise follicular development during the inter-ovulatory interval (interval between 2 consecutive ovulations) under tropical conditions. Non-lactating, 2- to 4-year-old crossbred Barbados-Black Belly × White Virgin Island ewes weighing a mean 30.4 kg with mean body condition score 2.9 (score 1–5) were used during September–November for the study. Ewes were maintained in a paddock of 100 m2 at the research farm

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Hart, Robert D., Graham A. Bowmaker, Eban N. de Silva, Brian W. Skelton, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXV Synthesis, Spectroscopy and Structural Systematics of Some 1 : 3 Adducts of Copper(I) Compounds with Triphenylarsine, [(Ph3As)3CuX], X = Cl, Br, I, ONO2." Australian Journal of Chemistry 50, no. 6 (1997): 553. http://dx.doi.org/10.1071/c96032.

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Crystallization of some copper(I) salts, CuX, with triphenylarsine in 1 : 3 stoichiometry from acetonitrile has yielded an array of adducts, [(Ph3As)3CuX], characterized by room-temperature single crystal X-ray structure determinations. [(Ph3As)3CuCl] (1) has been characterized in two unsolvated phases, α and β, the second form previously recorded as monoclinic, P21/n, Z = 8. The ‘α’ phase, like the bromide (2) and iodide (3), adopts the trigonal P3 array, widespread among many [(Ph3E)3MX] adducts with a ≈ 19, c ≈ 11 Å; conventional R on F was 0·037, 0·041, 0·056 for No 3458, 3259, 3434 indepe

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Menegotto, Giovana, Flávia Moraes Silva, Mirela Jobim de Azevedo, and Jussara Carnevale de Almeida. "Lunch energy density and the metabolic syndrome in patients with type 2 diabetes mellitus." British Journal of Nutrition 110, no. 9 (2013): 1656–63. http://dx.doi.org/10.1017/s0007114513000846.

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The aim of the present study was to investigate the possible associations between dietary energy density (ED) and the metabolic syndrome (MetS) in patients with type 2 diabetes. In the present case–control study, the dietary ED of 125 patients with type 2 diabetes (seventy-eight with (cases) the MetS and forty-seven without (controls) the MetS; mean age 62·0 (sd9·4) years, mean diabetes duration 12·5 (sd8·4) years and mean glycated Hb 7·2 (sd1·3) %) was assessed by weighed diet records. The MetS was defined according to the 2009 Joint Interim Statement and ED by the amount of energy (kJ) in a

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Simon, Laure, Paula Borrego, Dominique Darmaun, Arnaud Legrand, Jean-Christophe Rozé, and Anne Chauty-Frondas. "Effect of sex and gestational age on neonatal body composition." British Journal of Nutrition 109, no. 6 (2012): 1105–8. http://dx.doi.org/10.1017/s0007114512002991.

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To determine the effects of length of gestation and sex on infant body composition, air displacement plethysmography was performed in forty-six full-term neonates at 3 d of life and during the week prior to hospital discharge in 180 preterm neonates. Fat mass, as a percentage of body weight, was higher in preterm than in term infants (13·4 (sd 4·2) v. 10·1 (sd 3·7) %, respectively; P= 0·001). The absolute amount of fat mass did not differ between preterm and full-term newborns (323 (sd 126) v. 335 (sd 138) g; P= 0·58), whereas lean body mass was lower in preterm than in term infants (2055 (sd

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Safwan, Safwan, Shih-Wei Wang, George Hsiao, et al. "New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum." Marine Drugs 20, no. 2 (2022): 80. http://dx.doi.org/10.3390/md20020080.

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Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against al

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Gomes, Tiago Halyson de Oliveira, Beatriz Pellizzon, Giovanna Victória Moura Araújo, et al. "MAMOPLASTIA PÓS BARIÁTRICA." Revista ft 29, no. 144 (2025): 02–03. https://doi.org/10.69849/revistaft/fa10202503150102.

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INTRODUÇÃO: A mamoplastia pós bariátrica é um procedimento cirúrgico realizado para remodelar as mamas de pacientes que passaram por cirurgia bariátrica, visando corrigir a flacidez e o excesso de pele resultantes da perda significativa de peso. Esse procedimento é indicado para melhorar a estética e a autoestima dos pacientes, após a redução substancial de peso corporal. OBJETIVOS: O objetivo do presente trabalho foi realizar o levantamento acerca dos procedimentos cirúrgicos de mamoplastia pós bariátrica no Brasil, entre o período de 2013 a 2024. METODOLOGIA: O presente estudo trata-se de um

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Swan, Jeanette H., and Brian S. Meldrum. "Protection by NMDA Antagonists against Selective Cell Loss following Transient Ischaemia." Journal of Cerebral Blood Flow & Metabolism 10, no. 3 (1990): 343–51. http://dx.doi.org/10.1038/jcbfm.1990.63.

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We have administered antagonists acting competitively or noncompetitively at the N-methyl-D-aspartate receptor after a short period of incomplete ischaemia and evaluated selective neuronal loss in the CA1 region of the rat hippocampus. The competitive antagonists D-(–)-2-amino-7-phosphonoheptanoate (2APH); 100 or 330 mg/kg; 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP); 3.3 or 10 mg/kg; and CGS 19755 ( cis-4-phosphonomethyl-2-piperidine carboxylate) 3.3 or 10 mg/kg; and the noncompetitive antagonists MK801 {(+)5-methyl-10, 11-dihydro-5H-dibenzo[ a,d]cyclohepten-5,10-imine maleate}, 0.3

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Beltz, Mark W., and Frank W. Harris. "Synthesis and properties of aromatic polyimides containing oxyalkylene linkages." High Performance Polymers 7, no. 1 (1995): 23–40. http://dx.doi.org/10.1088/0954-0083/7/1/003.

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A series of para-catenated aromatic diamines containing oxyalkylene linkages, i.e., i.2-bis(4-aminophenoxy)ethane, bis[2-(4-aminnophenoxy)ethyl]ether, 1,2-bis[24{4-aminio-phenoxy)ethoxyjethane and bis{2-[2A4-aminophenoxy)ethoxy]ethyllether were polymerized with 3,3',4.4'benzophenonetetracarboxylic dianhydride (BTDA) and pyromellitic dianhydride. The poly(amic acid)s obtained were imidized by both chemical and thermal methods. It was postulated that the incorporation of the flexible linkages in the polyimides' backbones would result in solubility in organic solvents and moderate glass transitio

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Tomita, M., L. Xin, B. Freeman, S. Twomey, G. Pizzorno, and J. R. Murren. "Pharmacokinetic and pharmacodynamic analysis of topotecan administered in combination with PS 341 in patients with advanced malignancy." Journal of Clinical Oncology 24, no. 18_suppl (2006): 2033. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.2033.

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2033 Background: In vitro exposure to camptothecin results in down-regulation of the target enzyme, topoisomerase I (topo) via multi-ubiquitination and proteasomal degradation of the protein-linked DNA breaks. To prevent loss of topo, and thus circumvent a possible mechanism of resistance to the topo inhibitors, we conducted a dose escalating phase I study of topotecan in combination with the proteosome inhibitor PS 341. We now report the pharmacokinetic and pharmacodynamic analysis of the trial. Methods: Patients with advanced cancer were treated with topotecan alone at the following dose esc

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Roh, Kyoung Ho, Yu Kyung Kim, Shin-Woo Kim, et al. "Coinfections with Respiratory Pathogens among COVID-19 Patients in Korea." Canadian Journal of Infectious Diseases and Medical Microbiology 2021 (May 12, 2021): 1–9. http://dx.doi.org/10.1155/2021/6651045.

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The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in upper and lower respiratory specimens and coinfection with other respiratory pathogens in patients with coronavirus disease 2019 (COVID-19) was investigated. Study subjects (N = 342) were retrospectively enrolled after being confirmed as SARS-CoV-2 positive, and their nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and sputum specimens were restored for SARS-CoV-2 retesting and respiratory pathogen detection. The majority of the subjects (96.5%, N = 330) were confirmed as SARS-CoV-2 positive using NPS/OPS spe

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Guo, Changying, Shengjia Chen, Yongqiang Ye, Xiao-Bing Li, and Weimin Mao. "Anlotinib plus TQB2450 as adjuvant therapy in patients with esophageal squamous cell carcinoma: A phase II study (ALTER-E005)." Journal of Clinical Oncology 42, no. 3_suppl (2024): 347. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.347.

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347 Background: There is currently a limited range of therapeutic options available for postoperative patients (pts) with esophageal squamous cell carcinoma (ESCC), emphasizing the urgent requirement to investigate more efficient and safer postoperative treatment regimens for resectable ESCC. TQB2450, a novel PD-L1 blockade, has shown promising activity when combined with anlotinib, an antiangiogenic agent, in the treatment of various tumors, including advanced ESCC,1 and biliary tract cancer.2 The ALTER-E005 study aimed to evaluate the efficacy and safety of combining anlotinib with TQB2450 a

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Ahmadi, Hamed, Hooman Djaladat, Gus Miranda, Jie Cai, and Siamak Daneshmand. "Pre-cystectomy serum levels of CA19-9, CA125, and CEA: Correlation with pathologic stage and oncologic outcome in urothelial carcinoma of bladder." Journal of Clinical Oncology 31, no. 6_suppl (2013): 303. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.303.

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303 Background: To evaluate the association between pre-cystectomy carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), and carcinoembryonic antigen (CEA) levels and pathologic stage and oncological outcome of urothelial carcinoma of bladder (UCB). Methods: Preoperative stored serum samples of 186 patients with UCB who underwent radical cystectomy at USC between 2004 and 2009 were randomly selected to measure CA19-9, CA125, and CEA levels. Laboratory cut-off point values were used to define abnormal marker levels (CA 19-9>35.5, CA125>35.5, CEA>3.8). Pathologic stage w

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Copeland, Amy L., Michael S. Businelle, Diana W. Stewart, Scott M. Patterson, Carla J. Rash, and Colleen E. Carney. "Identifying Barriers to Entering Smoking Cessation Treatment Among Socioeconomically Disadvantaged Smokers." Journal of Smoking Cessation 5, no. 2 (2010): 164–71. http://dx.doi.org/10.1375/jsc.5.2.164.

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AbstractBackground:Efficacious smoking cessation interventions exist, yet few smokers utilise available resources such as psychosocial treatment programs and pharmacotherapy. The goals of the present study were to (1) identify perceived barriers to entering smoking cessation treatment programs among socioeconomically disadvantaged smokers, who are presently underrepresented in smoking cessation interventions; (2) determine what variables are most important in predicting the barriers identified (i.e., age, gender, ethnicity, income, nicotine dependence level, smoking rate, years smoking, stage

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Nissa, Ikka Malia Chairun. "Analisis Teknik Penerjemahan pada The Chronicles Of Narnia: Sang Singa, Penyihir, dan Lemari Karya Clive Staples Lewis (Analysis of Translation Techniques in Clive Staples Lewis’ The Chronicles of Narnia: The Lion, The Witch, and The Wardrobe)." JALABAHASA 13, no. 2 (2018): 165. http://dx.doi.org/10.36567/jalabahasa.v13i2.88.

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Penelitian ini mengenai teknik penerjemahan dalam sebuah novel The Chronicles of Narnia: The Lion, The Witch, and The Wardrobe. Novel ini memiliki dua versi bahasa, yaitu bahasa Inggris dan bahasa Indonesia. Ada beberapa teknik penerjemahan yang digunakan agar pembaca bisa memahami secara lebih baik. Penelitian ini bertujuan untuk mengetahui teknik penerjemahan yang digunakan dalam novel The Chronicles of Narnia: The Lion, The Witch, and The Wardrobe sebagai teks asli berbahasa Inggris dan diterjemahkan oleh Donna Widjajanto ke dalam bahasa Indonesia. Penelitian ini menggunakan desain peneliti

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Giagounidis, Aristoteles, Alan F. List, Eva Hellström-Lindberg, et al. "Prevalence and Impact on Outcomes of Additional Karyotypic Abnormalities in Patients (Pts) with Myelodysplastic Syndromes (MDS) and Del(5q) from the MDS-003 and MDS-004 Studies." Blood 126, no. 23 (2015): 1680. http://dx.doi.org/10.1182/blood.v126.23.1680.1680.

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Abstract Introduction: Approximately 50% of pts with de novoMDS present with cytogenetic abnormalities at diagnosis (Haase D, et al. Ann Hematol. 1995;70:171); deletion (del)5q occurs in ~15% of pts (Haase D, et al. Blood. 2007;110:4385). Cytogenetic abnormalities in addition to del(5q) may be associated with shorter overall survival (OS) and increased risk of progression to acute myeloid leukemia (AML) versus del(5q) alone (Mallo M, et al. Leukemia. 2011;25:110). In 2 large multicenter studies (MDS-003 and MDS-004), lenalidomide (LEN) was evaluated in red blood cell (RBC) transfusion-dependen

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