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Journal articles on the topic '346.546 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Al-Saleh, Stacy, Kendra Kamp, Sunanda Kane, Nancy Redeker, and Samantha Conley. "0920 Sleep Health and Cognitive Symptoms in Adults with Inflammatory Bowel Disease." SLEEP 47, Supplement_1 (2024): A395. http://dx.doi.org/10.1093/sleep/zsae067.0920.

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Abstract Introduction Inflammatory bowel disease (IBD) is a chronic immune-mediated disease that includes Crohn’s disease and ulcerative colitis. People with IBD experience poor sleep health, including short and highly fragmented sleep and extraintestinal manifestations including alterations to cognitive functioning; however, the relationships between sleep health and cognitive symptoms have not been evaluated in this population. The purpose of this study was to identify the associations between sleep health and perceived cognitive impairments in adults with IBD. Methods We conducted a descrip

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Abdullaiev, R. Ya, A. S. Yefimenko, L. A. Sysun, et al. "İŞEMİK İNSULT OLAN XƏSTƏLƏRDƏ YUXU ARTERİYASI ATEROSKLEROZUNUN SONOQRAFİK XÜSUSİYYƏTLƏRİ." Azerbaijan Medical Journal, no. 1 (March 28, 2024): 5–12. http://dx.doi.org/10.34921/amj.2024.1.001.

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The article presents the results of sonographic diagnosis of carotid atherosclerosis in 127 patients with ischemic stroke (IS) aged 38-74 year (average age 56±7 years). The comparison group (CG) consisted of 51 people with risk factors for cardiovascular diseases without a history of stroke. It has been established that arterial hypertension and type 2 diabetes mellitus are significantly more common among patients with IS than in patients of CG. The frequency of localization of atherosclerotic plaques on the walls of the carotid arteries was determined depending on the course of the stroke. Se

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Fuller, Gordon, Rachel Evans, Louise Preston, Helen Buckley Woods, and Suzanne Mason. "043 Should adults with mild head injury taking direct oral anticoagulants undergo CT scanning? A systematic review." Emergency Medicine Journal 36, no. 12 (2019): 805.1–805. http://dx.doi.org/10.1136/emermed-2019-rcem.43.

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BackgroundPatients taking direct oral anticoagulant medications (DOACs) commonly undergo computed tomography (CT) head scanning following mild head injury, regardless of symptoms or signs. International guidelines have noted a lack of evidence to support management decisions in such patients.MethodsA systematic review, pre-registered (CRD42017071411) and following Cochrane Collaboration recommendations, was performed. Studies of adults with mild head injury (GCS 13–15) taking DOACs, which reported the risk of adverse outcome following the head injury, were eligible for inclusion. A comprehensi

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Collette, Christopher, Amani M. Norling, Randall A. Walden, et al. "30 Hippocampal Internal Architecture Subfield Volumes Associated with Systematic Inflammatory Biomarkers in Multiple Sclerosis." Journal of the International Neuropsychological Society 29, s1 (2023): 546–47. http://dx.doi.org/10.1017/s1355617723007014.

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Objective:Multiple Sclerosis (MS) affects up to 500,000 adults in the United States, with cognitive impairment present in 45%-65% of people. Studies showed hippocampal atrophy in MS, but the underlying mechanisms remain unknown. Inflammation has been proposed to play a significant role, and associations between systemic inflammatory biomarkers and hippocampal atrophy have been shown in other neurological conditions. However, research exploring serum biomarker and volumetric associations in MS are lacking. Given that conventional imaging methods lack resolution for hippocampal internal architec

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Qayyum, Waqar, Asma Naseem, Muhammad Nadeem, Sumaira Mushtaq, Rabia Tahir, and Qurra tul Ain. "Incidence and Outcomes of Renal Derangements in Covid-19 Patients of a Tertiary Care Hospital." Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University 21, no. 1 (2025): 235–39. https://doi.org/10.48036/apims.v21i1.1322.

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Objective: To assess the incidence and outcomes of acute kidney injury in patients diagnosed with Covid-19. Methodology: This cross-sectional study was carried out in the department of medicine, Shaikh Khalifa Bin Zayed Al Nahyan Hospital/CMH, Rawalakot, AJK, Pakistan from May 2021 to May 2023. Total 676 patients (ages ? 18 years) admitted with Covid-19 confirmed through polymerase chain reaction (PCR) having normal renal function tests (RFTs) at admission were included in the study. RFTs were done during admission and patients were followed up for outcome. The kidney disease improving global

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Lucas, C., S. Rodriguez, R. Jean, et al. "AB0034 EARLY IMMUNIZATION AGAINST TREATMENT IS ASSOCIATED TO POOR CLINICAL RESPONSE AT 6 MONTHS AND LOW NUMBER OF TRANSITIONAL B CELLS AT BASELINE IN RHEUMATOID ARTHRITIS PATIENTS TREATED BY ADALIMUMAB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1319.1–1320. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3938.

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Background:Circulating anti-drug antibodies (ADAs) are detectable approximatively in 33% of adalimumab treated rheumatoid arthritis (RA) patients, often within the first 6 months of therapy1-2. Classically, circulating ADAs associate with their specific drugs to form immune complexes, increasing drug clearance, and by this mechanism reducing therapeutic effect3. B cell involvement leading to ADAs production is not yet well established.Objectives:To study early ADAs formation according to clinical response to an adalimumab therapy in RA patients and the relationship between ADAs and circulating

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Giacchetti, Sylvie, Enora Laas, Thomas Bachelot, et al. "Influence of hormone therapy timing intake on disease free survival (DFS) for patients with high-risk early breast cancer: Results of the UCBG-UNIRAD phase III randomized trial." Journal of Clinical Oncology 41, no. 16_suppl (2023): 546. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.546.

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546 Background: Circadian rhythms regulate the cellular and molecular processes that determine treatment effects. Scarce data suggest that daily timing could influence endocrine therapy (ET) pharmacology. We prospectively tested this hypothesis within the UNIRAD adjuvant phase III trial (NCT01805271) in patients (pts) with hormone receptors positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC). Methods: Between June 2013 and March 2020, 1,278 pts with high-risk HR+/HER2- primary BC were randomly assigned to adjuvant ET combined with EVE or placebo. Pts

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Sandboge, Samuel, Katri Räikkönen, Marius Lahti-Pulkkinen, et al. "Effect of Vitamin D₃ Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years." JAMA Network Open 6, no. 5 (2023): e2314319. http://dx.doi.org/10.1001/jamanetworkopen.2023.14319.

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ImportanceVitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown.ObjectiveTo determine the impact of high-dose (1200 IU) vs standard-dose (400 IU) vitamin D3 supplementation during the first 2 years on psychiatric symptoms at ages 6 to 8 years and whether the impact is different in children with lower vs higher maternal vitamin D3 levels; lower vs higher levels were defined as 25-hydroxyvitamin D (25[OH]D) less than 30 ng/mL vs 30 ng/mL or greater.Design, Setting, and ParticipantsThis study was a long-term follow-up of the

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Bowmaker, Graham A., Effendy, Robert D. Hart, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXIII Synthesis, Spectroscopy and Structural Systematics of New 1 : 1 'Cubane' Tetramers of Copper(I) and Silver(I) Halides with Triphenylarsine." Australian Journal of Chemistry 50, no. 6 (1997): 653. http://dx.doi.org/10.1071/c96039.

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Syntheses and room-temperature single-crystal X-ray structural characterization of a number of 1 : 1 ‘cube tetramer’ adducts of copper(I) and silver(I) halides, MX, with triphenylarsine, AsPh3, are recorded, being [XM(AsPh3)]4. The CuBr adduct, obtained unsolvated from toluene, orthorhombic Pbcn, a 17·844(5), b 20·778(8), c 18·430(4) Å, Z = 4 tetramers, conventional R on |F| 0·058 for No 1309 independent ‘observed’ reflctions (I > 3σ(I)), is isomorphous with previously recorded [ClAg(PPh3)]4, the tetramer having crystallographically imposed 2 symmetry. The CuI adduct, previously recorded as

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Borad, Mitesh J., Shantan G. Reddy, Nathan Bahary, et al. "Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer." Journal of Clinical Oncology 33, no. 13 (2015): 1475–81. http://dx.doi.org/10.1200/jco.2014.55.7504.

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Purpose TH-302 is an investigational hypoxia-activated prodrug that releases the DNA alkylator bromo-isophosphoramide mustard in hypoxic settings. This phase II study (NCT01144455) evaluated gemcitabine plus TH-302 in patients with previously untreated, locally advanced or metastatic pancreatic cancer. Patients and Methods Patients were randomly assigned 1:1:1 to gemcitabine (1,000 mg/m2), gemcitabine plus TH-302 240 mg/m2 (G+T240), or gemcitabine plus TH-302 340 mg/m2 (G+T340). Randomized crossover after progression on gemcitabine was allowed. The primary end point was progression-free surviv

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Manpoong, Chowlani, and S. K. Tripathi. "Soil properties under different land use systems of Mizoram, North East India." Journal of Applied and Natural Science 11, no. 1 (2019): 121–25. http://dx.doi.org/10.31018/jans.v11i1.1999.

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Changes in land use and improper soil management have led to severe land degradation around the globe through the modification in soil physicochemical and biological processes. This study aimed to assess the soil properties of different land use system types. Soil samples (0-15 cm depth) were collected from five land uses; Rubber Plantation (RP), Oil Palm Plantation (OPP), Bamboo Forest (BF), Fallow Land (FL) and Natural Forest (NF) and analyzed for bulk density, soil texture, soil pH, soil moisture, soil carbon, total nitrogen, ammonium, nitrate, soil microbial biomass carbon, soil respiratio

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Ross, M. G., D. J. Sherman, M. G. Ervin, L. Day, and J. Humme. "Fetal swallowing: response to systemic hypotension." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 1 (1990): R130—R134. http://dx.doi.org/10.1152/ajpregu.1990.258.1.r130.

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The fetal swallowing and endocrine responses to systemic hypotension were studied in five chronically instrumented ovine fetuses (125 +/- 2 days). Fetuses were prepared with bipolar electrodes inserted in the thyrohyoid muscle, nuchal esophagus, and thoracic esophagus, a flow probe surrounding the thoracic esophagus, and arterial and venous catheters. In response to an intravenous infusion of sodium nitroprusside, fetal mean arterial blood pressure decreased from 50.8 +/- 3.6 to 41.7 +/- 3.8 mmHg. Fetal plasma renin activity (5.0 +/- 1.4-25.1 +/- 10.3 ng.ml-1.h-1) and arginine vasopressin (5.6

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Cabri, L. J., A. M. McDonald, C. J. Stanley, et al. "Naldrettite, Pd2Sb, a new intermetallic mineral from the Mesamax Northwest deposit, Ungava region, Québec, Canada." Mineralogical Magazine 69, no. 1 (2005): 89–97. http://dx.doi.org/10.1180/0026461056910236.

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AbstractNaldrettite, Pd2Sb, is a new intermetallic mineral discovered in the Mesamax Northwest deposit, Cape Smith fold belt, Ungava region, northern Québec. It is associated with monoclinic pyrrhotite, pentlandite, chalcopyrite, galena, sphalerite, cobaltite, clinochlore, magnetite, sudburyite (PdSb), electrum and altaite. Other rarer associated minerals include a second new mineral (ungavaite, Pd4Sb3), sperrylite (PtAs2), michenerite (PdBiTe), petzite (Ag3AuTe4) and hessite (Ag2Te). Naldrettite occurs as anhedral grains, which are commonly attached or moulded to sulphide minerals, and also a

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Demetri, George D., Jason J. Luke, Antoine Hollebecque, et al. "First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3004. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3004.

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3004 Background: ABBV-085 is an ADC (conjugated to monomethyl auristatin E, drug:antibody ratio of 2:1) directed against leucine-rich repeat containing 15 (LRRC15), a type 1 transmembrane protein highly expressed on the surface of sarcomas and cancer-associated fibroblasts in stroma of many other cancers. ABBV-085 induced antitumor activity in both in vitro and xenograft models of sarcoma. This phase 1, first-in-human, 2-part study assessed the safety/tolerability of ABBV-085 in patients (pts) with advanced solid tumors (NCT02565758). Methods: Eligible pts (≥18 yr; advanced solid tumors) recei

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Gaujoux-Viala, C., A. Basch, S. Lassoued, et al. "AB0451 FRENCH REAL LIFE SAFETY DATA ON THE USE OF TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: OBSERVATIONAL STUDY, DEFACTO." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1415.1–1415. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1170.

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BackgroundTofacitinib, an oral Janus Kinase inhibitor, is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis (RA).ObjectivesTo describe the safety profile of Tofacitinib in a French prospective observational study DeFacTo.MethodsThe safety profile of tofacitinib was assessed using interim data from a descriptive analysis of patients who took at least one dose of tofacitinib in the DeFacTo study.ResultsAmong 314 patients enrolled in the study, 306 received tofacitinib and were included in the safety analysis, including 274 patients with a follow-up

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Pekov, Igor V., Natalia V. Zubkova, Vasiliy O. Yapaskurt, et al. "New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. VI. Melanarsite, K3Cu7Fe3+O4(AsO4)4." Mineralogical Magazine 80, no. 5 (2016): 855–67. http://dx.doi.org/10.1180/minmag.2016.080.027.

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AbstractThe new mineral melanarsite, K3Cu7Fe3+O4(AsO4)4, was found in the sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka Peninsula, Russia. It is associated with dmisokolovite, shchurovskyite, bradaczekite, hematite, tenorite, aphthitalite, johillerite, arsmirandite, As-bearing orthoclase, hatertite, pharmazincite, etc. Melanarsite occurs as tabular to prismatic crystals up to 0.4 mm, separate or combined in clusters up to 1 mm across or in interrupted crusts up to 0.02 cm × 1 c

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Sarmiento, R., T. Jeerakathil, A. Sheriff, et al. "B.2 Short-term outcome in simultaneous acute code stroke activations in the emergency department." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 50, s2 (2023): S50. http://dx.doi.org/10.1017/cjn.2023.84.

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Background: We aim to assess the effect of simultaneous acute code stroke activation(ACSA) in patients undergoing reperfusion therapies in the emergency department on home time at 90 days. Methods: We assessed ACSA over 20 months from the QuICR(Quality Improvement and Clinical Research Alberta Stroke Program) Registry. We defined Simultaneous reperfusion therapy as, ACSA within 60 min of the arrival of any patient receiving intravenous thrombolysis or ACSA within 150 min of the arrival of any patient receiving endovascular thrombectomy (based on the Canadian Triage and Acuity Scale, average lo

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Banas, Michael D., Sunil Baldwa, Gen Suzuki, John M. Canty, and James A. Fallavollita. "Determinants of contractile reserve in viable, chronically dysfunctional myocardium." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H2791—H2797. http://dx.doi.org/10.1152/ajpheart.01384.2006.

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There is considerable variability in the sensitivity of inotropic reserve to identify viability in chronically dysfunctional myocardium. This is partially related to the underlying pathophysiology, with more frequent contractile reserve in chronically stunned (with normal resting perfusion) than hibernating myocardium (with reduced flow). This study was undertaken to determine the physiological responses to transient and graded stimulation in chronically stunned and hibernating myocardium to define the relative roles of acute catecholamine desensitization and biphasic responses. Pigs were chro

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Nemec, James M., and Hugh C. Harris. "Evidence for Mass Segregation in NGC 5466." Symposium - International Astronomical Union 126 (1988): 677–78. http://dx.doi.org/10.1017/s0074180900043576.

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Forty-eight blue straggler stars have been discovered in NGC 5466, the only Galactic globular cluster known to contain an anomalous Cepheid of the sort found in dwarf galaxies. The stars were identified in color-magnitude diagrams constructed from photometry of deep photographic plates taken with the Canada-France-Hawaii 3.6 m telescope (calibrated with new UBV photoelectric photometry), and from point spread function photometry of CCD frames taken with the Palomar 5 m telescope. The stars typically have magnitudes <V> ~ 19.m1 and colors <B-V> ~ 0.m2. Forty-two of the 48 stars are

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Te, Valerie Li Thiao, Remi Favier, Jeanne-Yvonne Borg, et al. "Evaluation of Inherited Prothrombotic Risk Factors in Children with Acute Lymphoblastic Leukemia." Blood 110, no. 11 (2007): 3953. http://dx.doi.org/10.1182/blood.v110.11.3953.3953.

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Abstract This retrospective study was designed to determine the prevalence of inherited prothrombotic risk factors (Factor V Leiden (FV) G1691A and prothrombin G20210A mutations, TT677 genotype of the methylenetetrahydrofolate reductase (MTHFR), protein C, protein S, antithrombin deficiencies) in a population of children with ALL treated according to the FRALLE 2000 study Protocol (High Risk and Standard Risk groups). The study was performed in 5 French Centers including Amiens, Angers, Paris Trousseau, Rouen and Saint-Etienne. From December 2000 to March 2006, 354 children aged 1 to 18 years

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Krasowski, M. J., M. B. Lavigne, J. Olesinski, and P. Y. Bernier. "Advantages of long-term measurement of fine root demographics with a minirhizotron at two balsam fir sites." Canadian Journal of Forest Research 40, no. 6 (2010): 1128–35. http://dx.doi.org/10.1139/x10-068.

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We used 15 site-years of minirhizotron observations (1998–2006 at one site; 1998–2000 and 2004–2006 at second site) from two mature balsam fir ( Abies balsamea (L.) Mill.) sites to quantify interannual variability in fine root demography and assess the accuracy of estimates from early years of observation. Annual production varied fourfold at Forêt Montmorency (FM) (5.8–26.5 roots·100 cm–2) and twofold at Green River (GR) (7.2–14.2 roots·100 cm–2). Annual mortality varied more than 30-fold at the two sites (FM: 0.7–23.2 roots·100 cm–2; GR: 0.3–10.9 roots·100 cm–2), year-end standing crops vari

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Domullodzhanov, Daler, and Rahmonkul Rahmatilloev. "Development of low-cost rainwater harvesting to support on-site water supply in rural Tajikistan." Central Asian Journal of Water Research 9, no. 2 (2023): 103–20. http://dx.doi.org/10.29258/cajwr/2023-r1.v9-2/103-120.eng.

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Farmers in remote, arid areas, far from available water sources, need affordable water solutions for household and livestock use. In this study, the water needs and potential for rainwater harvesting (RWH) in the Kysylsu River Basin are estimated at different altitudes. The mean annual net rainfall depth varied from 545 to 900 mm. With an average roof area of 550 m2, 211 m3 to 344 m3 rainwater can be harvested for dry and wet years respectively. Based on the estimated water demand and rainfall deficit, the average household need was estimated to be 100 m3. For a low-cost water storage solution

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Tomah, Shaheen, Veronica Salsberg, Ahmed H. Eldib, Mhd Wael Tasabehji, and Osama Hamdy. "Dairy Consumption and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes and Obesity During Intensive Lifestyle Intervention: A 6-Month Prospective Cohort Study." Current Developments in Nutrition 4, Supplement_2 (2020): 668. http://dx.doi.org/10.1093/cdn/nzaa049_061.

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Abstract Objectives To evaluate the association between dairy consumption and A1C, body weight, and cardiometabolic risk factors in patients with type 2 diabetes (T2D) and obesity enrolled in a 12-week intensive lifestyle intervention (ILI) program in real-world clinical practice. Methods We evaluated 45 subjects with T2D and obesity enrolled in a 12-week ILI program (mean age 56 ± 9 yrs, 40% female, diabetes duration 10.9 ± 7 yrs, A1C 7.9 ± 1.3%, body weight 106 ± 19 kg, BMI 36 ± 5 kg/m2, and caloric intake 1880 ± 544 kcal/d). We divided the cohort based on weekly average dairy consumption du

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Cagini, Carlo, Adriana Pellegrino, Alessia Iannone, et al. "Comparison of anti-inflammatory effects of eye drops formulations after uncomplicated cataract surgery." Therapeutic Advances in Ophthalmology 12 (January 2020): 251584142092430. http://dx.doi.org/10.1177/2515841420924304.

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Aim: The aim of this study is to compare the efficacy of different dexamethasone eye drops formulations in controlling postoperative inflammation. Methods: Cataract surgery was carried out in 72 patients (35 males) divided into two groups: group A (36 patients, mean age = 78.0 ± 5.6) received four times daily for 2 weeks a suspension containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml, and group B (36 patients, mean age = 76.2 ± 6.8) a solution containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml. Both groups received ofloxacin 0.5% four times daily for 7 days, and nepafenac 0.1

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Patel, Neil D., Patrick M. Sullivan, Cheryl M. Takao, Sarah Badran, and Frank F. Ing. "Stent treatment of ostial branch pulmonary artery stenosis: initial and medium-term outcomes and technical considerations to avoid and minimise stent malposition." Cardiology in the Young 30, no. 2 (2019): 256–62. http://dx.doi.org/10.1017/s1047951119003032.

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AbstractObjective:Stenting of ostial pulmonary artery stenosis presents several unique challenges. These include difficulty in defining anatomy and need for precise stent placement in order to avoid missing the ostial stenosis or jailing either the contralateral branch pulmonary artery or the ipsilateral upper lobe branch.Design:A retrospective review of outcomes was conducted in 1.5 or 2-ventricle patients who underwent stent placement for ostial branch pulmonary artery stenosis. Specific catheterisation lab techniques were reviewed.Results:Forty-seven branch pulmonary arteries underwent sten

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Mahbobeh, Samani, Motealleh Alireza, Yazdani Soheila, and Abbasi Leila. "Effects of Myofascial Release Technique on Pain and Disability in Patients with Chronic Lumbar Disc Herniation: A Randomized Trial." Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 27, no. 04 (2017): 218–25. http://dx.doi.org/10.1055/s-0043-115906.

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Abstract Background Disc herniation is one of the factors that causes low back pain (LBP). Objective This study aimed to evaluate the effect of a myofascial release technique on pain and disability in patients with chronic lumbar disc herniation. Method 30 patients with a herniated lumbar disc, divided into 2 groups. One group (n=15) received electrotherapeutic modalities (TENS, pulsed ultrasound, hot packs) in addition to the myofascial release technique (MFR) on trigger points in 9 soft tissue elements. The other group (n=15) received only electrotherapeutic modalities. All patients underwen

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Good, David W., Thampi George, and Bruns A. Watts. "Aldosterone potentiates 1,25-dihydroxyvitamin D3 action in renal thick ascending limb via a nongenomic, ERK-dependent pathway." American Journal of Physiology-Cell Physiology 285, no. 5 (2003): C1122—C1130. http://dx.doi.org/10.1152/ajpcell.00125.2003.

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Recently, we demonstrated that aldosterone inhibits HCO3- absorption in the rat medullary thick ascending limb (MTAL) via a nongenomic pathway blocked by inhibitors of extracellular signal-regulated kinase (ERK) activation. Here we examined the effects on the MTAL of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], which regulates cell functions through nongenomic mechanisms in nonrenal systems. Addition of 1 nM 1,25(OH)2D3 to the bath decreased HCO3- absorption by 24%, from 15.0 ± 0.3 to 11.4 ± 0.5 pmol· min-1· mm-1 ( P < 0.001). This inhibition was maximal within 60 min and was eliminated by pretr

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Shimizu, M., A. Kato, S. Matsubara, A. J. Criddle, and C. J. Stanley. "Watanabeite, Cu4(As,Sb)2S5, a new mineral from the Teine mine, Sapporo, Hokkaido, Japan." Mineralogical Magazine 57, no. 389 (1993): 643–49. http://dx.doi.org/10.1180/minmag.1993.057.389.08.

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AbstractWatanabeite Cu4(As,Sb)2S5, in which As>Sb, is a new copper sulphosalt that occurs with quartz in a hydrothermal vein at the Teine mine, Sapporo, Hokkaido, Japan. It is silvery lead-grey in colour with lead-grey streak. VHN100 = 253-306 kg/mm2, brittle. It has no cleavage and the fracture is uneven. The measured density = 4.66(2) g/cm3. The mean of six microprobe analyses gave Cu 41.1, Ag 0.1, Mn 0.3, As 15.4, Sb 14.3, Bi 2.4, S 26.2, a total of 99.8 wt.%, corresponding to: (Cu3.94Mn0.03− Ag0.01)∑3.98(As1.25Sb0.72Bi0.07)∑2.04S4.98 (basis: total atoms = 11), or ideally, Cu4(As,Sb)2S5,

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Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Bukulova, N. Yu. "Predicting the course of ulcerative colitis in children at the stage of hospital treatment." PROBLEMS OF UNINTERRUPTED MEDICAL TRAINING AND SCIENCE 42, no. 2 (2021): 69–74. http://dx.doi.org/10.31071/promedosvity2021.02.069.

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The problem of predicting the course of ulcerative colitis (UC), its complications, the effectiveness of the therapy is an urgent task of practical health care, and its solution will improve the efficiency of diagnosis and treatment of this complex pathology of childhood. The aim of the work — to develop a model for predicting a continuously recurrent course of UC in children. Clinical and statistical analysis of 52 case histories of children with UC in the dynamics of treatment was carried out. The patients were divided into 2 groups: group I — 24 (46 %) children within 6 months achieved clin

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Luchristt, Douglas, C. Emi Bretschneider, Kimberly Kenton, Melissa Simon, and Oluwateniola Brown. "Inequities in Filled Overactive Bladder Medication Prescriptions in the US." JAMA Network Open 6, no. 5 (2023): e2315074. http://dx.doi.org/10.1001/jamanetworkopen.2023.15074.

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ImportanceAnticholinergic medications to treat overactive bladder (OAB) have been associated with increased risk of cognitive decline, whereas β3-adrenoceptor agonists (hereafter, β3-agonists) have comparable efficacy and do not carry the same risk. Yet, anticholinergics remain the predominant OAB medication prescribed in the US.ObjectiveTo evaluate whether patient race, ethnicity, and sociodemographic characteristics are associated with receipt of anticholinergic vs β3-agonist OAB medications.Design, Setting, and ParticipantsThis study is a cross-sectional analysis of the 2019 Medical Expendi

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Lücke, Lennart, Christoph Fusch, Katja Knab, et al. "Reproducibility of Air Displacement Plethysmography in Term and Preterm Infants—A Study to Enhance Body Composition Analysis in Clinical Routine." Nutrients 16, no. 12 (2024): 1810. http://dx.doi.org/10.3390/nu16121810.

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The quality-initiative analysis of weekly duplicate PEAPOD® body composition measurements was conducted from clinical practice (January to September 2021) on preterm and term infants without respiratory support. Statistical analysis, including regression analysis, Bland–Altman plots and cv-root-mean-square tests, was performed. A total of 188 duplicate (376 individual) measurements were collected from 119 infants (88 preterm, 31 term). The median absolute difference between duplicates was 31.5 g for fat-free mass (FFM). Linear correlation analysis showed R2 = 0.97 for FFM. The absolute differe

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Zhao, Aihua, Yang Luo, and Man-Keun Yoon. "The Impact of Digital Literacy on ICT Teaching Innovation Behaviors Among Chinese High School Teachers: An Analysis of the Roles of Teacher Engagement and Teacher Learning Communities." Association of Global Studies Education 16, no. 4 (2024): 209–40. https://doi.org/10.19037/agse.16.4.08.

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This study aims to investigate the impact of digital literacy on ICT teaching innovation behaviors among high school teachers in China, as well as the roles of teacher engagement and teacher learning communities within this relationship. Using established measurement scales for each variable, the study surveyed 526 Chinese high school teachers and conducted statistical analysis on the valid data using SPSS 28.0 and SPSS Process Macro 4.2. The results indicated that: (1) Teachers' digital literacy has a significant positive effect on ICT teaching innovation behaviors (β = .317, p < .001) and

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Zheng, Hao, Meng Lv, Chenhua Yan, et al. "Mega-Dose Decitabine Intensified Regimen Is More Effective at Eliminating Pre-HSCT Measurable Residual Disease Compared to the Bu/Cy Regimen: A Multicenter Prospective Phase II Study." Blood 142, Supplement 1 (2023): 471. http://dx.doi.org/10.1182/blood-2023-188932.

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Background: Acute myeloid leukemia (AML) patients with high-risk pre-HSCT measurable residual disease (MRD, KMT2A-r, etc.) have a high relapse rate (&gt;50%) even after allogeneic hematopoietic stem cell transplantation(allo-HSCT). In 2018, we developed two multi-institutional, single-arm, prospective phase II trials, to investigate the efficacy and safety of a novel intensified conditioning with “Mega-Dose 400mg/m 2” decitabine following allo-HSCT for high-risk MRD AML (NCT03793517). Method： Inclusion: 1) Detectable pre-HSCT MRD detected by recurrent genetic abnormalities (KMT2A-r, DEK, e

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Hansra, Damien Mikael, Amber Moran, Becky Slawik, et al. "Evaluation of pathologic and genomic characteristics in female breast cancer patients." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13001-e13001. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13001.

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e13001 Background: The genomic landscape of female breast cancer is rapidly evolving partially owing to advancements in next generation sequencing (NGS). Here we report the genomic characteristics of female breast cancer patients with locally recurrent inoperable and metastatic disease. Methods: IRB approval was obtained for a retrospective analysis of archived pathology on patients treated at Cancer Treatment Centers of America. Comprehensive genomic profiling of tumors was derived from Foundation One (F1) and Guardant 360 NGS. Clinical information was derived from retrospective chart review.

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Käyrä, M., S. Kortelainen, J. Paltta, et al. "AB0890 EARLY SYSTEMIC SCLEROSIS PATIENTS SHOW A SLOW DISEASE COURSE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1659.3–1660. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5461.

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BackgroundSystemic sclerosis is a heterogenous immune-mediated connective tissue disease characterized by vasculopathy and progressive tissue and organ fibrosis. [1]ObjectivesOur aim was to determine characteristics of Finnish patients with systemic sclerosis (SSc) and early SSc that were followed during 1996-2018 in two university hospitals in Finland.MethodsThe data of patients with SSc with ICD-10 diagnostic code (M34) were collected retrospectively from medical registers. The patients were reclassified into different subsets based on the ACR/ EULAR (American College of Rheumatology and Eur

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Figueiredo, Pedro, Júlio Costa, Michele Lastella, João Morais, and João Brito. "Sleep Indices and Cardiac Autonomic Activity Responses during an International Tournament in a Youth National Soccer Team." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 2076. http://dx.doi.org/10.3390/ijerph18042076.

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This study aimed to describe habitual sleep and nocturnal cardiac autonomic activity (CAA), and their relationship with training/match load in male youth soccer players during an international tournament. Eighteen elite male youth soccer players (aged 14.8 ± 0.3 years; mean ± SD) participated in the study. Sleep indices were measured using wrist actigraphy, and heart rate (HR) monitors were used to measure CAA during night-sleep throughout 5 consecutive days. Training and match loads were characterized using the session-rating of perceived exertion (s-RPE). During the five nights 8 to 17 playe

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Adebayo-Ojo, Temitope Christina, Janine Wichmann, Oluwaseyi Olalekan Arowosegbe, Nicole Probst-Hensch, Christian Schindler, and Nino Künzli. "Short-Term Joint Effects of PM10, NO2 and SO2 on Cardio-Respiratory Disease Hospital Admissions in Cape Town, South Africa." International Journal of Environmental Research and Public Health 19, no. 1 (2022): 495. http://dx.doi.org/10.3390/ijerph19010495.

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Background/Aim: In sub-Sahara Africa, few studies have investigated the short-term association between hospital admissions and ambient air pollution. Therefore, this study explored the association between multiple air pollutants and hospital admissions in Cape Town, South Africa. Methods: Generalized additive quasi-Poisson models were used within a distributed lag linear modelling framework to estimate the cumulative effects of PM10, NO2, and SO2 up to a lag of 21 days. We further conducted multi-pollutant models and stratified our analysis by age group, sex, and season. Results: The overall r

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Sultana, Mst Tasmim, Ashrifa Akter Mukta, Abu Saeid, and Md Masud Rana. "Nutritional and microbiological quality assessment of commercial yogurt sold in different districts of Bangladesh: a food safety issue." Asian-Australasian Journal of Food Safety and Security 4, no. 2 (2020): 66–72. http://dx.doi.org/10.3329/aajfss.v4i2.53881.

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The aim of this study was to investigate the nutritional and microbial quality of yoghurt from different districts of Bangladesh. Protein content was higher (4.56g/kg) in SB2 (sample Bogura-2), fat content was also higher (5.67g/kg) in SB3 (sample Bogura-3). The acidity found ranged from 0.77% to 0.98%, pH obtained ranged between 3.6 to 4.98 and total solid retained between 23.08 to 26.95 for all samples. Highest Total Viable count (TVC) value was found in SB2 (68.9×104±0.23 CFU/ml) and lowest value was observed in SJ2 (23.01×104±0.43 CFU/ml). No mold and yeast were found in the collected samp

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Edwards, David G., Matthew S. Roy, and Raju Y. Prasad. "Wave reflection augments central systolic and pulse pressures during facial cooling." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 6 (2008): H2535—H2539. http://dx.doi.org/10.1152/ajpheart.01369.2007.

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Cardiovascular events are more common in the winter months, possibly because of hemodynamic alterations in response to cold exposure. The purpose of this study was to determine the effect of acute facial cooling on central aortic pressure, arterial stiffness, and wave reflection. Twelve healthy subjects (age 23 ± 3 yr; 6 men, 6 women) underwent supine measurements of carotid-femoral pulse wave velocity (PWV), brachial artery blood pressure, and central aortic pressure (via the synthesis of a central aortic pressure waveform by radial artery applanation tonometry and generalized transfer functi

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Douabul, A. A. Z., and A. A. K. Al-Timari. "On the Organochlorine pesticide residues in the Marshes, Shatt Al-Arab and the Arabian Gulf system." Mesopotamian Journal of Marine Sciences 29, no. 2 (2022): 97–114. http://dx.doi.org/10.58629/mjms.v29i2.129.

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Organochlorine pesticides are a class of toxic compounds characterized by their relative chemical and biological stability. They are ubiquitous in the environments and are soluble in liquids. Consequently Organochlorine pesticides have been placed on “the top of black list” of potential environmental hazards. Studies on Organochlorine residues have been carried out between 1979-1991. The residues were determined in water, sediments and organisms collected from the Marshes, Shatt Al-Arab and the Arabian Gulf system. Most of the data confirmed the present of ∑DDT, Endrin, Dieldrin, Chlordane and

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Aupiais, Camille, Romain Basmaci, Brice Ilharreborde, et al. "Arthritis in children: comparison of clinical and biological characteristics of septic arthritis and juvenile idiopathic arthritis." Archives of Disease in Childhood 102, no. 4 (2016): 316–22. http://dx.doi.org/10.1136/archdischild-2016-310594.

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AimChildhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses.MethodsChildren <16 years of age hospitalised in a French tertiary care centre for a first episode of arthritis lasting for less than 6 weeks who underwent joint aspiration were retrospectively included. We performed non-parametrical tests to compare groups (septic arthritis (SA), juvenile idiopathic arthritis (JIA) and arthritis with no definitive d

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De Souza, Jonas A., Brisa Aschebrook-Kilfoy, Raymon Grogan, Bonnie J. Yap, Christopher Daugherty, and David Cella. "Grading financial toxicity based upon its impact on health-related quality of life (HRQol)." Journal of Clinical Oncology 34, no. 3_suppl (2016): 16. http://dx.doi.org/10.1200/jco.2016.34.3_suppl.16.

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16 Background: Financial toxicity (FTox) is an important symptom. We hypothesized that FTox can be graded based on statistically significant and clinically meaningful changes in HRQoL. Methods: FTox was assessed by the COST (COmprehensive Score for financial Toxicity) in 2 sets of cancer patients (pts). Set 1(S1): pts with Stage IV cancers on chemotherapy. Gradations of FTox were determined by ROC analyses based on conventions for clinically meaningful small (0.2), medium (0.5) and large (0.8) effect sizes (e.s.) for the FACT-G HRQoL instrument. Demographics, income, mood disorders (POMS), and

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Mroczek, Tomasz, Magdalena Czerżyńska, Julita Sacharczuk, et al. "Recoarctation of the aorta after the Norwood procedure may be treated during the second stage of the surgical palliation." European Journal of Cardio-Thoracic Surgery 56, no. 6 (2019): 1186–91. http://dx.doi.org/10.1093/ejcts/ezz241.

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Abstract OBJECTIVES Recoarctation of the aorta (re-CoA) after the Norwood procedure is traditionally treated during catheter-based aortoplasty (CB-A) performed as a separate procedure preceding stage II surgical palliation (S II SP). Our goal was to determine the efficacy of the protocol according to which re-CoA after the Norwood procedure in patients with hypoplastic left heart syndrome is treated during S II SP using hybrid catheter-based aortoplasty. METHODS We compared 2 groups of infants who developed re-CoA after the Norwood procedure and were treated at the same institution: In group I

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Sominina, A. A., D. M. Danilenko, K. A. Stolyarov, et al. "Interference of SARS-CoV-2 with other Respiratory Viral Infections agents during Pandemic." Epidemiology and Vaccinal Prevention 20, no. 4 (2021): 28–39. http://dx.doi.org/10.31631/2073-3046-2021-20-4-28-39.

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Background. Integrative epidemiological and etiological analysis of peculiarities of the development of the COVID-19 pandemic in different countries of the world is of significant scientific and practical interest in order to improve the preparedness of medical and social services during the upcoming pandemics. The purpose of the research. To determine the features of the epidemic process caused by a new coronavirus infection COVID-19, in all the diversity of its interaction with influenza viruses and other ARVI agents in the Russian Federation.Materials and methods. The studies were performed

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Hedman, Christina A., Jan Frystyk, Torbjörn Lindström та ін. "Residual β-Cell Function More than Glycemic Control Determines Abnormalities of the Insulin-Like Growth Factor System in Type 1 Diabetes". Journal of Clinical Endocrinology & Metabolism 89, № 12 (2004): 6305–9. http://dx.doi.org/10.1210/jc.2004-0572.

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Abstract The GH-IGF-I axis is disturbed in patients with type 1 diabetes. Our aim was to investigate whether abnormalities are found in patients in very good glycemic control and, if so, to estimate the role of residual β-cell function. Patients with hemoglobin A1c (HbA1c) less than 6% (reference range, 3.6–5.4%) were selected for the study. Twenty-two men and 24 women, aged 41.3 ± 13.8 yr (mean ± sd), with a diabetes duration of 17.8 ± 14.6 yr participated. Healthy controls (15 women and nine men), aged 41.3 ± 13.0 yr, were also studied. Overnight fasting serum samples were analyzed for HbA1c

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Zhao, Wenling, Mingyue Zhang, Jin Liu, et al. "Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice." Anesthesiology 131, no. 1 (2019): 94–104. http://dx.doi.org/10.1097/aln.0000000000002753.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by the volatile anesthetic isoflurane contributes to reduced hippocampal pyramidal neuron excitability. Methods Whole-cell patch-clamp recordings of sodium currents of hippocampal cornu a

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Rosada, M. O., T. G. Hlushkevych, A. M. Sboieva, O. V. Surmasheva, and O. V. Molchanets. "Microbiological spectrum of causative agents of healthcare-associated infections isolated in Ukraine in 2022-2023." Environment & Health, no. 4 (113) (December 2024): 60–64. https://doi.org/10.32402/dovkil2024.04.060.

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The purpose of the study is to identify strains of microorganisms, pathogens of infections associated with the provision of medical care, isolated from patients in Ukraine in 2022-2023. Research materials and methods: Strains of microorganisms that came to the Reference Laboratory for the diagnosis of tuberculosis, bacterial, parasitic and especially dangerous pathogens of the Public Health Center of the Ministry of Health of Ukraine from the regional centers of disease control and prevention and health care institutions of Ukraine were studied. Microorganisms were identified using the VITEK 2

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