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Journal articles on the topic '346.546.1 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Bowmaker, Graham A., Effendy, Robert D. Hart, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXIII Synthesis, Spectroscopy and Structural Systematics of New 1 : 1 'Cubane' Tetramers of Copper(I) and Silver(I) Halides with Triphenylarsine." Australian Journal of Chemistry 50, no. 6 (1997): 653. http://dx.doi.org/10.1071/c96039.

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Syntheses and room-temperature single-crystal X-ray structural characterization of a number of 1 : 1 ‘cube tetramer’ adducts of copper(I) and silver(I) halides, MX, with triphenylarsine, AsPh3, are recorded, being [XM(AsPh3)]4. The CuBr adduct, obtained unsolvated from toluene, orthorhombic Pbcn, a 17·844(5), b 20·778(8), c 18·430(4) Å, Z = 4 tetramers, conventional R on |F| 0·058 for No 1309 independent ‘observed’ reflctions (I > 3σ(I)), is isomorphous with previously recorded [ClAg(PPh3)]4, the tetramer having crystallographically imposed 2 symmetry. The CuI adduct, previously recorded as

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Manpoong, Chowlani, and S. K. Tripathi. "Soil properties under different land use systems of Mizoram, North East India." Journal of Applied and Natural Science 11, no. 1 (2019): 121–25. http://dx.doi.org/10.31018/jans.v11i1.1999.

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Changes in land use and improper soil management have led to severe land degradation around the globe through the modification in soil physicochemical and biological processes. This study aimed to assess the soil properties of different land use system types. Soil samples (0-15 cm depth) were collected from five land uses; Rubber Plantation (RP), Oil Palm Plantation (OPP), Bamboo Forest (BF), Fallow Land (FL) and Natural Forest (NF) and analyzed for bulk density, soil texture, soil pH, soil moisture, soil carbon, total nitrogen, ammonium, nitrate, soil microbial biomass carbon, soil respiratio

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Collette, Christopher, Amani M. Norling, Randall A. Walden, et al. "30 Hippocampal Internal Architecture Subfield Volumes Associated with Systematic Inflammatory Biomarkers in Multiple Sclerosis." Journal of the International Neuropsychological Society 29, s1 (2023): 546–47. http://dx.doi.org/10.1017/s1355617723007014.

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Objective:Multiple Sclerosis (MS) affects up to 500,000 adults in the United States, with cognitive impairment present in 45%-65% of people. Studies showed hippocampal atrophy in MS, but the underlying mechanisms remain unknown. Inflammation has been proposed to play a significant role, and associations between systemic inflammatory biomarkers and hippocampal atrophy have been shown in other neurological conditions. However, research exploring serum biomarker and volumetric associations in MS are lacking. Given that conventional imaging methods lack resolution for hippocampal internal architec

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Demetri, George D., Jason J. Luke, Antoine Hollebecque, et al. "First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3004. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3004.

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3004 Background: ABBV-085 is an ADC (conjugated to monomethyl auristatin E, drug:antibody ratio of 2:1) directed against leucine-rich repeat containing 15 (LRRC15), a type 1 transmembrane protein highly expressed on the surface of sarcomas and cancer-associated fibroblasts in stroma of many other cancers. ABBV-085 induced antitumor activity in both in vitro and xenograft models of sarcoma. This phase 1, first-in-human, 2-part study assessed the safety/tolerability of ABBV-085 in patients (pts) with advanced solid tumors (NCT02565758). Methods: Eligible pts (≥18 yr; advanced solid tumors) recei

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Qayyum, Waqar, Asma Naseem, Muhammad Nadeem, Sumaira Mushtaq, Rabia Tahir, and Qurra tul Ain. "Incidence and Outcomes of Renal Derangements in Covid-19 Patients of a Tertiary Care Hospital." Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University 21, no. 1 (2025): 235–39. https://doi.org/10.48036/apims.v21i1.1322.

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Objective: To assess the incidence and outcomes of acute kidney injury in patients diagnosed with Covid-19. Methodology: This cross-sectional study was carried out in the department of medicine, Shaikh Khalifa Bin Zayed Al Nahyan Hospital/CMH, Rawalakot, AJK, Pakistan from May 2021 to May 2023. Total 676 patients (ages ? 18 years) admitted with Covid-19 confirmed through polymerase chain reaction (PCR) having normal renal function tests (RFTs) at admission were included in the study. RFTs were done during admission and patients were followed up for outcome. The kidney disease improving global

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Pekov, Igor V., Natalia V. Zubkova, Vasiliy O. Yapaskurt, et al. "New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. VI. Melanarsite, K3Cu7Fe3+O4(AsO4)4." Mineralogical Magazine 80, no. 5 (2016): 855–67. http://dx.doi.org/10.1180/minmag.2016.080.027.

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AbstractThe new mineral melanarsite, K3Cu7Fe3+O4(AsO4)4, was found in the sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka Peninsula, Russia. It is associated with dmisokolovite, shchurovskyite, bradaczekite, hematite, tenorite, aphthitalite, johillerite, arsmirandite, As-bearing orthoclase, hatertite, pharmazincite, etc. Melanarsite occurs as tabular to prismatic crystals up to 0.4 mm, separate or combined in clusters up to 1 mm across or in interrupted crusts up to 0.02 cm × 1 c

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Lucas, C., S. Rodriguez, R. Jean, et al. "AB0034 EARLY IMMUNIZATION AGAINST TREATMENT IS ASSOCIATED TO POOR CLINICAL RESPONSE AT 6 MONTHS AND LOW NUMBER OF TRANSITIONAL B CELLS AT BASELINE IN RHEUMATOID ARTHRITIS PATIENTS TREATED BY ADALIMUMAB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1319.1–1320. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3938.

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Background:Circulating anti-drug antibodies (ADAs) are detectable approximatively in 33% of adalimumab treated rheumatoid arthritis (RA) patients, often within the first 6 months of therapy1-2. Classically, circulating ADAs associate with their specific drugs to form immune complexes, increasing drug clearance, and by this mechanism reducing therapeutic effect3. B cell involvement leading to ADAs production is not yet well established.Objectives:To study early ADAs formation according to clinical response to an adalimumab therapy in RA patients and the relationship between ADAs and circulating

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Ross, M. G., D. J. Sherman, M. G. Ervin, L. Day, and J. Humme. "Fetal swallowing: response to systemic hypotension." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 1 (1990): R130—R134. http://dx.doi.org/10.1152/ajpregu.1990.258.1.r130.

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The fetal swallowing and endocrine responses to systemic hypotension were studied in five chronically instrumented ovine fetuses (125 +/- 2 days). Fetuses were prepared with bipolar electrodes inserted in the thyrohyoid muscle, nuchal esophagus, and thoracic esophagus, a flow probe surrounding the thoracic esophagus, and arterial and venous catheters. In response to an intravenous infusion of sodium nitroprusside, fetal mean arterial blood pressure decreased from 50.8 +/- 3.6 to 41.7 +/- 3.8 mmHg. Fetal plasma renin activity (5.0 +/- 1.4-25.1 +/- 10.3 ng.ml-1.h-1) and arginine vasopressin (5.6

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Borad, Mitesh J., Shantan G. Reddy, Nathan Bahary, et al. "Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer." Journal of Clinical Oncology 33, no. 13 (2015): 1475–81. http://dx.doi.org/10.1200/jco.2014.55.7504.

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Purpose TH-302 is an investigational hypoxia-activated prodrug that releases the DNA alkylator bromo-isophosphoramide mustard in hypoxic settings. This phase II study (NCT01144455) evaluated gemcitabine plus TH-302 in patients with previously untreated, locally advanced or metastatic pancreatic cancer. Patients and Methods Patients were randomly assigned 1:1:1 to gemcitabine (1,000 mg/m2), gemcitabine plus TH-302 240 mg/m2 (G+T240), or gemcitabine plus TH-302 340 mg/m2 (G+T340). Randomized crossover after progression on gemcitabine was allowed. The primary end point was progression-free surviv

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Gaujoux-Viala, C., A. Basch, S. Lassoued, et al. "AB0451 FRENCH REAL LIFE SAFETY DATA ON THE USE OF TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: OBSERVATIONAL STUDY, DEFACTO." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1415.1–1415. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1170.

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BackgroundTofacitinib, an oral Janus Kinase inhibitor, is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis (RA).ObjectivesTo describe the safety profile of Tofacitinib in a French prospective observational study DeFacTo.MethodsThe safety profile of tofacitinib was assessed using interim data from a descriptive analysis of patients who took at least one dose of tofacitinib in the DeFacTo study.ResultsAmong 314 patients enrolled in the study, 306 received tofacitinib and were included in the safety analysis, including 274 patients with a follow-up

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Banas, Michael D., Sunil Baldwa, Gen Suzuki, John M. Canty, and James A. Fallavollita. "Determinants of contractile reserve in viable, chronically dysfunctional myocardium." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H2791—H2797. http://dx.doi.org/10.1152/ajpheart.01384.2006.

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There is considerable variability in the sensitivity of inotropic reserve to identify viability in chronically dysfunctional myocardium. This is partially related to the underlying pathophysiology, with more frequent contractile reserve in chronically stunned (with normal resting perfusion) than hibernating myocardium (with reduced flow). This study was undertaken to determine the physiological responses to transient and graded stimulation in chronically stunned and hibernating myocardium to define the relative roles of acute catecholamine desensitization and biphasic responses. Pigs were chro

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Cabri, L. J., A. M. McDonald, C. J. Stanley, et al. "Naldrettite, Pd2Sb, a new intermetallic mineral from the Mesamax Northwest deposit, Ungava region, Québec, Canada." Mineralogical Magazine 69, no. 1 (2005): 89–97. http://dx.doi.org/10.1180/0026461056910236.

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AbstractNaldrettite, Pd2Sb, is a new intermetallic mineral discovered in the Mesamax Northwest deposit, Cape Smith fold belt, Ungava region, northern Québec. It is associated with monoclinic pyrrhotite, pentlandite, chalcopyrite, galena, sphalerite, cobaltite, clinochlore, magnetite, sudburyite (PdSb), electrum and altaite. Other rarer associated minerals include a second new mineral (ungavaite, Pd4Sb3), sperrylite (PtAs2), michenerite (PdBiTe), petzite (Ag3AuTe4) and hessite (Ag2Te). Naldrettite occurs as anhedral grains, which are commonly attached or moulded to sulphide minerals, and also a

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Giacchetti, Sylvie, Enora Laas, Thomas Bachelot, et al. "Influence of hormone therapy timing intake on disease free survival (DFS) for patients with high-risk early breast cancer: Results of the UCBG-UNIRAD phase III randomized trial." Journal of Clinical Oncology 41, no. 16_suppl (2023): 546. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.546.

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546 Background: Circadian rhythms regulate the cellular and molecular processes that determine treatment effects. Scarce data suggest that daily timing could influence endocrine therapy (ET) pharmacology. We prospectively tested this hypothesis within the UNIRAD adjuvant phase III trial (NCT01805271) in patients (pts) with hormone receptors positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC). Methods: Between June 2013 and March 2020, 1,278 pts with high-risk HR+/HER2- primary BC were randomly assigned to adjuvant ET combined with EVE or placebo. Pts

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Te, Valerie Li Thiao, Remi Favier, Jeanne-Yvonne Borg, et al. "Evaluation of Inherited Prothrombotic Risk Factors in Children with Acute Lymphoblastic Leukemia." Blood 110, no. 11 (2007): 3953. http://dx.doi.org/10.1182/blood.v110.11.3953.3953.

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Abstract This retrospective study was designed to determine the prevalence of inherited prothrombotic risk factors (Factor V Leiden (FV) G1691A and prothrombin G20210A mutations, TT677 genotype of the methylenetetrahydrofolate reductase (MTHFR), protein C, protein S, antithrombin deficiencies) in a population of children with ALL treated according to the FRALLE 2000 study Protocol (High Risk and Standard Risk groups). The study was performed in 5 French Centers including Amiens, Angers, Paris Trousseau, Rouen and Saint-Etienne. From December 2000 to March 2006, 354 children aged 1 to 18 years

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Good, David W., Thampi George, and Bruns A. Watts. "Aldosterone potentiates 1,25-dihydroxyvitamin D3 action in renal thick ascending limb via a nongenomic, ERK-dependent pathway." American Journal of Physiology-Cell Physiology 285, no. 5 (2003): C1122—C1130. http://dx.doi.org/10.1152/ajpcell.00125.2003.

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Recently, we demonstrated that aldosterone inhibits HCO3- absorption in the rat medullary thick ascending limb (MTAL) via a nongenomic pathway blocked by inhibitors of extracellular signal-regulated kinase (ERK) activation. Here we examined the effects on the MTAL of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], which regulates cell functions through nongenomic mechanisms in nonrenal systems. Addition of 1 nM 1,25(OH)2D3 to the bath decreased HCO3- absorption by 24%, from 15.0 ± 0.3 to 11.4 ± 0.5 pmol· min-1· mm-1 ( P < 0.001). This inhibition was maximal within 60 min and was eliminated by pretr

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Mahbobeh, Samani, Motealleh Alireza, Yazdani Soheila, and Abbasi Leila. "Effects of Myofascial Release Technique on Pain and Disability in Patients with Chronic Lumbar Disc Herniation: A Randomized Trial." Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 27, no. 04 (2017): 218–25. http://dx.doi.org/10.1055/s-0043-115906.

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Abstract Background Disc herniation is one of the factors that causes low back pain (LBP). Objective This study aimed to evaluate the effect of a myofascial release technique on pain and disability in patients with chronic lumbar disc herniation. Method 30 patients with a herniated lumbar disc, divided into 2 groups. One group (n=15) received electrotherapeutic modalities (TENS, pulsed ultrasound, hot packs) in addition to the myofascial release technique (MFR) on trigger points in 9 soft tissue elements. The other group (n=15) received only electrotherapeutic modalities. All patients underwen

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Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Cagini, Carlo, Adriana Pellegrino, Alessia Iannone, et al. "Comparison of anti-inflammatory effects of eye drops formulations after uncomplicated cataract surgery." Therapeutic Advances in Ophthalmology 12 (January 2020): 251584142092430. http://dx.doi.org/10.1177/2515841420924304.

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Aim: The aim of this study is to compare the efficacy of different dexamethasone eye drops formulations in controlling postoperative inflammation. Methods: Cataract surgery was carried out in 72 patients (35 males) divided into two groups: group A (36 patients, mean age = 78.0 ± 5.6) received four times daily for 2 weeks a suspension containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml, and group B (36 patients, mean age = 76.2 ± 6.8) a solution containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml. Both groups received ofloxacin 0.5% four times daily for 7 days, and nepafenac 0.1

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Nemec, James M., and Hugh C. Harris. "Evidence for Mass Segregation in NGC 5466." Symposium - International Astronomical Union 126 (1988): 677–78. http://dx.doi.org/10.1017/s0074180900043576.

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Forty-eight blue straggler stars have been discovered in NGC 5466, the only Galactic globular cluster known to contain an anomalous Cepheid of the sort found in dwarf galaxies. The stars were identified in color-magnitude diagrams constructed from photometry of deep photographic plates taken with the Canada-France-Hawaii 3.6 m telescope (calibrated with new UBV photoelectric photometry), and from point spread function photometry of CCD frames taken with the Palomar 5 m telescope. The stars typically have magnitudes <V> ~ 19.m1 and colors <B-V> ~ 0.m2. Forty-two of the 48 stars are

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Lücke, Lennart, Christoph Fusch, Katja Knab, et al. "Reproducibility of Air Displacement Plethysmography in Term and Preterm Infants—A Study to Enhance Body Composition Analysis in Clinical Routine." Nutrients 16, no. 12 (2024): 1810. http://dx.doi.org/10.3390/nu16121810.

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The quality-initiative analysis of weekly duplicate PEAPOD® body composition measurements was conducted from clinical practice (January to September 2021) on preterm and term infants without respiratory support. Statistical analysis, including regression analysis, Bland–Altman plots and cv-root-mean-square tests, was performed. A total of 188 duplicate (376 individual) measurements were collected from 119 infants (88 preterm, 31 term). The median absolute difference between duplicates was 31.5 g for fat-free mass (FFM). Linear correlation analysis showed R2 = 0.97 for FFM. The absolute differe

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Patel, Neil D., Patrick M. Sullivan, Cheryl M. Takao, Sarah Badran, and Frank F. Ing. "Stent treatment of ostial branch pulmonary artery stenosis: initial and medium-term outcomes and technical considerations to avoid and minimise stent malposition." Cardiology in the Young 30, no. 2 (2019): 256–62. http://dx.doi.org/10.1017/s1047951119003032.

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AbstractObjective:Stenting of ostial pulmonary artery stenosis presents several unique challenges. These include difficulty in defining anatomy and need for precise stent placement in order to avoid missing the ostial stenosis or jailing either the contralateral branch pulmonary artery or the ipsilateral upper lobe branch.Design:A retrospective review of outcomes was conducted in 1.5 or 2-ventricle patients who underwent stent placement for ostial branch pulmonary artery stenosis. Specific catheterisation lab techniques were reviewed.Results:Forty-seven branch pulmonary arteries underwent sten

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Hedman, Christina A., Jan Frystyk, Torbjörn Lindström та ін. "Residual β-Cell Function More than Glycemic Control Determines Abnormalities of the Insulin-Like Growth Factor System in Type 1 Diabetes". Journal of Clinical Endocrinology & Metabolism 89, № 12 (2004): 6305–9. http://dx.doi.org/10.1210/jc.2004-0572.

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Abstract The GH-IGF-I axis is disturbed in patients with type 1 diabetes. Our aim was to investigate whether abnormalities are found in patients in very good glycemic control and, if so, to estimate the role of residual β-cell function. Patients with hemoglobin A1c (HbA1c) less than 6% (reference range, 3.6–5.4%) were selected for the study. Twenty-two men and 24 women, aged 41.3 ± 13.8 yr (mean ± sd), with a diabetes duration of 17.8 ± 14.6 yr participated. Healthy controls (15 women and nine men), aged 41.3 ± 13.0 yr, were also studied. Overnight fasting serum samples were analyzed for HbA1c

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Adebayo-Ojo, Temitope Christina, Janine Wichmann, Oluwaseyi Olalekan Arowosegbe, Nicole Probst-Hensch, Christian Schindler, and Nino Künzli. "Short-Term Joint Effects of PM10, NO2 and SO2 on Cardio-Respiratory Disease Hospital Admissions in Cape Town, South Africa." International Journal of Environmental Research and Public Health 19, no. 1 (2022): 495. http://dx.doi.org/10.3390/ijerph19010495.

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Background/Aim: In sub-Sahara Africa, few studies have investigated the short-term association between hospital admissions and ambient air pollution. Therefore, this study explored the association between multiple air pollutants and hospital admissions in Cape Town, South Africa. Methods: Generalized additive quasi-Poisson models were used within a distributed lag linear modelling framework to estimate the cumulative effects of PM10, NO2, and SO2 up to a lag of 21 days. We further conducted multi-pollutant models and stratified our analysis by age group, sex, and season. Results: The overall r

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Käyrä, M., S. Kortelainen, J. Paltta, et al. "AB0890 EARLY SYSTEMIC SCLEROSIS PATIENTS SHOW A SLOW DISEASE COURSE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1659.3–1660. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5461.

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BackgroundSystemic sclerosis is a heterogenous immune-mediated connective tissue disease characterized by vasculopathy and progressive tissue and organ fibrosis. [1]ObjectivesOur aim was to determine characteristics of Finnish patients with systemic sclerosis (SSc) and early SSc that were followed during 1996-2018 in two university hospitals in Finland.MethodsThe data of patients with SSc with ICD-10 diagnostic code (M34) were collected retrospectively from medical registers. The patients were reclassified into different subsets based on the ACR/ EULAR (American College of Rheumatology and Eur

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De Agustin, J. J., G. Añez, D. Reina-Sanz, et al. "AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1787–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1397.

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BackgroundWe conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice.ObjectivesObtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables.MethodsPhase IV, multicenter, prospective and open-label clinical trialconductedin 9 centresfrom 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 U

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Zheng, Hao, Meng Lv, Chenhua Yan, et al. "Mega-Dose Decitabine Intensified Regimen Is More Effective at Eliminating Pre-HSCT Measurable Residual Disease Compared to the Bu/Cy Regimen: A Multicenter Prospective Phase II Study." Blood 142, Supplement 1 (2023): 471. http://dx.doi.org/10.1182/blood-2023-188932.

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Background: Acute myeloid leukemia (AML) patients with high-risk pre-HSCT measurable residual disease (MRD, KMT2A-r, etc.) have a high relapse rate (&gt;50%) even after allogeneic hematopoietic stem cell transplantation(allo-HSCT). In 2018, we developed two multi-institutional, single-arm, prospective phase II trials, to investigate the efficacy and safety of a novel intensified conditioning with “Mega-Dose 400mg/m 2” decitabine following allo-HSCT for high-risk MRD AML (NCT03793517). Method： Inclusion: 1) Detectable pre-HSCT MRD detected by recurrent genetic abnormalities (KMT2A-r, DEK, e

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Zhao, Aihua, Yang Luo, and Man-Keun Yoon. "The Impact of Digital Literacy on ICT Teaching Innovation Behaviors Among Chinese High School Teachers: An Analysis of the Roles of Teacher Engagement and Teacher Learning Communities." Association of Global Studies Education 16, no. 4 (2024): 209–40. https://doi.org/10.19037/agse.16.4.08.

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This study aims to investigate the impact of digital literacy on ICT teaching innovation behaviors among high school teachers in China, as well as the roles of teacher engagement and teacher learning communities within this relationship. Using established measurement scales for each variable, the study surveyed 526 Chinese high school teachers and conducted statistical analysis on the valid data using SPSS 28.0 and SPSS Process Macro 4.2. The results indicated that: (1) Teachers' digital literacy has a significant positive effect on ICT teaching innovation behaviors (β = .317, p < .001) and

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Diamanti-Kandarakis, Evanthia, Giovanna Spina, Chryssa Kouli, and Ilias Migdalis. "Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 4666–73. http://dx.doi.org/10.1210/jcem.86.10.7904.

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Women with polycystic ovary syndrome who present with hyperandrogenemia, hyperinsulinemia, and insulin resistance appear to be at high risk of cardiovascular disease. Elevated levels of endothelin-1, a marker of vasculopathy, have been reported in insulin-resistant subjects with endothelial dysfunction. Male gender also seems to be an aggravating factor for cardiovascular disease. In this study we investigated endothelin-1 levels in women with polycystic ovary syndrome, and we evaluated the effect of an insulin sensitizer, metformin, on endothelin-1 levels. Plasma endothelin-1 levels were meas

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Cappellini, Maria Domenica, Amal El-Beshlawy, Antonis Kattamis, et al. "Efficacy and Safety of Deferasirox (Exjade®) in Patients with Transfusion- Dependent Anemias: 1-Year Results from the Large, Prospective, Multicenter EPIC Study." Blood 112, no. 11 (2008): 3875. http://dx.doi.org/10.1182/blood.v112.11.3875.3875.

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Abstract Background: Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy for treating transfusional iron overload. In registration trials, the starting dose was based on baseline liver iron concentration (LIC). The prospective multicenter EPIC trial, the largest ever conducted for an iron chelator, included patients (pts) with a variety of transfusion-dependent anemias and was designed to evaluate the efficacy and safety of fixed starting doses of deferasirox based on transfusion history, with subsequent dose titration based on serum ferritin (SF) trends. On

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Cheung, Harry, Marwan M. Azar, Geliang Gan, et al. "1099. Opportunistic Infections Among Long Term Survivors of Kidney Transplantation: Defining Risk Factors." Open Forum Infectious Diseases 7, Supplement_1 (2020): S579—S580. http://dx.doi.org/10.1093/ofid/ofaa439.1285.

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Abstract Background Opportunistic infections (OIs) in kidney transplant recipients (KTR) most commonly occur in the early post-transplant period or with increased immunosuppression, largely as a result of impaired T-cell function. Additionally, age confers susceptibility to infection independent of time post-transplant. The combined impact of cumulative immunosuppression and immunosenescence on infection risk of long-term KT survivors has not been well described. Methods We performed a retrospective chart review of patients age ≥ 18 years who underwent KT between 2003 to 2009 and who survived

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Hellmann, Matthew D., Scott Joseph Antonia, Ani Sarkis Balmanoukian, et al. "Updated overall survival and safety profile of durvalumab monotherapy in advanced NSCLC." Journal of Clinical Oncology 36, no. 5_suppl (2018): 169. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.169.

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169 Background: Single-agent durvalumab is being evaluated in patients with advanced squamous and non-squamous NSCLC in an ongoing Phase 1/2 study (NCT01693562). Here we present updated survival and safety data in NSCLC patients. Methods: Treatment-naïve (1L) and previously treated (2L or 3L+) stage IIIB/IV NSCLC patients received durvalumab 10 mg/kg Q2W for up to 12 months. Patients were stratified by tumor PD-L1 expression (Ventana PD-L1 [SP263] Assay [PD-L1 high: ≥25% of tumor cells with membrane staining]), treatment line, and histology. Results: As of 05 September 2017, 304 NSCLC patients

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Aupiais, Camille, Romain Basmaci, Brice Ilharreborde, et al. "Arthritis in children: comparison of clinical and biological characteristics of septic arthritis and juvenile idiopathic arthritis." Archives of Disease in Childhood 102, no. 4 (2016): 316–22. http://dx.doi.org/10.1136/archdischild-2016-310594.

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AimChildhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses.MethodsChildren <16 years of age hospitalised in a French tertiary care centre for a first episode of arthritis lasting for less than 6 weeks who underwent joint aspiration were retrospectively included. We performed non-parametrical tests to compare groups (septic arthritis (SA), juvenile idiopathic arthritis (JIA) and arthritis with no definitive d

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Bukulova, N. Yu. "Predicting the course of ulcerative colitis in children at the stage of hospital treatment." PROBLEMS OF UNINTERRUPTED MEDICAL TRAINING AND SCIENCE 42, no. 2 (2021): 69–74. http://dx.doi.org/10.31071/promedosvity2021.02.069.

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The problem of predicting the course of ulcerative colitis (UC), its complications, the effectiveness of the therapy is an urgent task of practical health care, and its solution will improve the efficiency of diagnosis and treatment of this complex pathology of childhood. The aim of the work — to develop a model for predicting a continuously recurrent course of UC in children. Clinical and statistical analysis of 52 case histories of children with UC in the dynamics of treatment was carried out. The patients were divided into 2 groups: group I — 24 (46 %) children within 6 months achieved clin

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Davies, HL, PP Mann, and B. Goddard. "A comparison of the effects of feed supplements cobalt and selenium, and perennial and annual pastures on the production of medium Peppin Merino weaner sheep in south-western Australia." Australian Journal of Experimental Agriculture 29, no. 3 (1989): 361. http://dx.doi.org/10.1071/ea9890361.

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Two experiments on weaner production are reported. In experiment 1, the liveweight and wool production were measured in medium Peppin Merino sheep that grazed at 10.5 weanerstha 8 plots of a mixed Phalaris aquatica-subterranean clover pasture or 8 plots of annual pasture (Trifolium subterraneum cv. Woogenellup and volunteer annual grass species). This was repeated over 2 years using autumn-born sheep; 4 groups on each pasture type were offered no supplement, 2 groups a cereal supplement (340 goats), and 2 groups of supplement isoenergetic with the cereal group but having a high protein meal re

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Magrey, M., M. G. H. Van de Sande, M. Breban, et al. "POS1107 BIMEKIZUMAB ACHIEVED SUSTAINED IMPROVEMENTS IN EFFICACY OUTCOMES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS, REGARDLESS OF PRIOR TNF INHIBITOR TREATMENT: WEEK 52 POOLED RESULTS FROM TWO PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 876–77. http://dx.doi.org/10.1136/annrheumdis-2023-eular.836.

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BackgroundIn patients (pts) with axial spondyloarthritis (axSpA), tumour necrosis factor inhibitors (TNFi) are the usual first line biologic treatment, yet many pts may experience loss of response over time, and some are intolerant to TNFis.[1]Typically, response to second line biologics is limited in TNFi-inadequate responders (IR).Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In the phase 3 BE MOBILE 1 and 2 studies, BKZ treatment resulted in rapid and sustained improvements in efficacy outcomes through 52 weeks (wks) in pts with acti

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De Souza, Jonas A., Brisa Aschebrook-Kilfoy, Raymon Grogan, Bonnie J. Yap, Christopher Daugherty, and David Cella. "Grading financial toxicity based upon its impact on health-related quality of life (HRQol)." Journal of Clinical Oncology 34, no. 3_suppl (2016): 16. http://dx.doi.org/10.1200/jco.2016.34.3_suppl.16.

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16 Background: Financial toxicity (FTox) is an important symptom. We hypothesized that FTox can be graded based on statistically significant and clinically meaningful changes in HRQoL. Methods: FTox was assessed by the COST (COmprehensive Score for financial Toxicity) in 2 sets of cancer patients (pts). Set 1(S1): pts with Stage IV cancers on chemotherapy. Gradations of FTox were determined by ROC analyses based on conventions for clinically meaningful small (0.2), medium (0.5) and large (0.8) effect sizes (e.s.) for the FACT-G HRQoL instrument. Demographics, income, mood disorders (POMS), and

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Dervis, Sheila, Geoff B. Coombs, Georgia K. Chaseling, Davide Filingeri, Jovana Smoljanic, and Ollie Jay. "A comparison of thermoregulatory responses to exercise between mass-matched groups with large differences in body fat." Journal of Applied Physiology 120, no. 6 (2016): 615–23. http://dx.doi.org/10.1152/japplphysiol.00906.2015.

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We sought to determine 1) the influence of adiposity on thermoregulatory responses independently of the confounding biophysical factors of body mass and metabolic heat production (Hprod); and 2) whether differences in adiposity should be accounted for by prescribing an exercise intensity eliciting a fixed Hprod per kilogram of lean body mass (LBM). Nine low (LO-BF) and nine high (HI-BF) body fat males matched in pairs for total body mass (TBM; LO-BF: 88.7 ± 8.4 kg, HI-BF: 90.1 ± 7.9 kg; P = 0.72), but with distinctly different percentage body fat (%BF; LO-BF: 10.8 ± 3.6%; HI-BF: 32.0 ± 5.6%; P

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Hansra, Damien Mikael, Amber Moran, Becky Slawik, et al. "Evaluation of pathologic and genomic characteristics in female breast cancer patients." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13001-e13001. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13001.

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e13001 Background: The genomic landscape of female breast cancer is rapidly evolving partially owing to advancements in next generation sequencing (NGS). Here we report the genomic characteristics of female breast cancer patients with locally recurrent inoperable and metastatic disease. Methods: IRB approval was obtained for a retrospective analysis of archived pathology on patients treated at Cancer Treatment Centers of America. Comprehensive genomic profiling of tumors was derived from Foundation One (F1) and Guardant 360 NGS. Clinical information was derived from retrospective chart review.

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Douabul, A. A. Z., and A. A. K. Al-Timari. "On the Organochlorine pesticide residues in the Marshes, Shatt Al-Arab and the Arabian Gulf system." Mesopotamian Journal of Marine Sciences 29, no. 2 (2022): 97–114. http://dx.doi.org/10.58629/mjms.v29i2.129.

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Organochlorine pesticides are a class of toxic compounds characterized by their relative chemical and biological stability. They are ubiquitous in the environments and are soluble in liquids. Consequently Organochlorine pesticides have been placed on “the top of black list” of potential environmental hazards. Studies on Organochlorine residues have been carried out between 1979-1991. The residues were determined in water, sediments and organisms collected from the Marshes, Shatt Al-Arab and the Arabian Gulf system. Most of the data confirmed the present of ∑DDT, Endrin, Dieldrin, Chlordane and

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Rodríguez Salas, G., A. M. Santos, V. Navarro-Compán, et al. "AB1023 THE DIFFERENTIAL CHARACTERISTIC OF SPONDYLOARTHRITIS PATIENTS WHO CANNOT BE CLASSIFIED ACCORDING TO ASAS: RESULTS FROM THE GESPA COLOMBIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1733.2–1734. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5271.

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BackgroundThe Assessment of SpondyloArthritis International Society (ASAS) classification criteria for SpA has changed the approach to the disease, enhancing the performance of the classification process. However, regardless of the ASAS classification criteria were developed according to a global cohort of patients, Latin American patients were not included in a significant number. SpA patients from our region have unique characteristics that may impact the SpA classification. Other alleles than HLA-B27 have been identified, the frequency of HLA-B15 was reported to be 19.1% in the Latin Americ

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Waterhouse, David, Amanda Shawky, Aanal Desai, et al. "Abstract 5946: Five-year real-world survival outcomes of patients with advanced non-small cell lung cancer receiving first-line immunotherapy-based regimens." Cancer Research 85, no. 8_Supplement_1 (2025): 5946. https://doi.org/10.1158/1538-7445.am2025-5946.

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Abstract Background: Five-year real-world outcomes of first-line (1L) immunotherapy (IO)-based regimens for advanced non-small cell lung cancer (aNSCLC) were assessed to describe how real-world outcomes correspond to those in clinical trials. Methods: Adult patients (pts) with aNSCLC from Flatiron Health database receiving 1L IO monotherapy or single-agent IO + chemotherapy from Jan 1, 2016 to Jun 30, 2024 were identified. Pts were excluded if they had EGFR/ALK mutations or unknown histology type. Overall survival (OS) and real-world progression-free survival (rwPFS) of each 1L treatment were

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Foá, Robin, Alice Di Rocco, Guy van Hazel, et al. "Maintenance Rituximab Every 2 Months for 2 Years Is Effective and Well Tolerated In Patients with Follicular Lymphoma with Both Standard or Rapid Infusion: Updated Results From the Phase IIIb MAXIMA Study." Blood 116, no. 21 (2010): 3945. http://dx.doi.org/10.1182/blood.v116.21.3945.3945.

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Abstract Abstract 3945 Background: MAXIMA is a Phase IIIb study evaluating the safety of rituximab (Rituxan®, MabThera®) maintenance therapy given at either a standard infusion rate or as a rapid infusion in patients with treatment-naïve or previously treated follicular lymphoma (FL) responding to induction treatment. The study also aims at confirming the effectiveness of rituximab maintenance therapy with respect to improvement of progression-free survival and overall survival, and the rate of conversion from partial response (PR) to complete response/unconfirmed complete response (CR/CRu) w

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Zimmer, A., A. Klein та G. Horneff. "SAT0491 PSORIASIS ASSOCIATED WITH MONOCLONAL-ANTIBODY-TNF-Α INHIBITORS VS. FUSION PROTEIN ETANERCEPT IN JUVENILE IDIOPATHIC ARTHRITIS PATIENTS - ANALYSIS OF THE BIKER REGISTRY". Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1202.1–1202. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4883.

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Background:Although efficacy of Tumor necrosis factor inhibitors (TNFi) for treatment of psoriasis is well established, patients may develop psoriasis for the first time while on TNFi as a paradoxical effect. Few data are available in patients with juvenile idiopathic arthritis (JIA).Objectives:To analyze the incidence of psoriasis in TNFi – treated JIA patients and to identify associated factors.Methods:Safety data from patients registered in the German Biologics registry (BIKeR) were analyzed. Cohorts of patients were grouped by treatment: any or multiple TNFi, single TNFi, biologics other t

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Czuczman, Myron S., Andrew Davies, Kim M. Linton, et al. "A Phase 2/3 Multicenter, Randomized Study Comparing the Efficacy and Safety of Lenalidomide Versus Investigator’s Choice in Relapsed/Refractory DLBCL." Blood 124, no. 21 (2014): 628. http://dx.doi.org/10.1182/blood.v124.21.628.628.

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Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma (NHL) comprising 3 molecular subtypes: germinal center B-cell (GCB), activated B-cell (ABC) and class III. ABC patients (pts) have a poor prognosis. The immunomodulatory drug lenalidomide (Len) produces durable responses in pts with aggressive NHL (Witzig 2011), with preferential activity reported in non-GCB DLBCL (Hernandez-Ilizaliturri 2011). Methods: This randomized, multicenter, open-label, phase 2/3 study was conducted to determine the efficacy and safety of single-agent Len vs single-agen

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Mroczek, Tomasz, Magdalena Czerżyńska, Julita Sacharczuk, et al. "Recoarctation of the aorta after the Norwood procedure may be treated during the second stage of the surgical palliation." European Journal of Cardio-Thoracic Surgery 56, no. 6 (2019): 1186–91. http://dx.doi.org/10.1093/ejcts/ezz241.

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Abstract OBJECTIVES Recoarctation of the aorta (re-CoA) after the Norwood procedure is traditionally treated during catheter-based aortoplasty (CB-A) performed as a separate procedure preceding stage II surgical palliation (S II SP). Our goal was to determine the efficacy of the protocol according to which re-CoA after the Norwood procedure in patients with hypoplastic left heart syndrome is treated during S II SP using hybrid catheter-based aortoplasty. METHODS We compared 2 groups of infants who developed re-CoA after the Norwood procedure and were treated at the same institution: In group I

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Luu, Huong, Gerald Spotts, Hartwig Gajek, et al. "ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin- Free Method] Post-Authorization Safety Surveillance (PASS): Safety and Efficacy Following Product Switch in Routine Clinical Practice." Blood 112, no. 11 (2008): 3375. http://dx.doi.org/10.1182/blood.v112.11.3375.3375.

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Abstract A prospective, non-interventional Post-Authorization Safety Surveillance (PASS) program was initiated in 2004 to document ADVATE safety and efficacy in routine clinical practice. More than 900 subjects newly prescribed ADVATE have been enrolled in the US, EU and Japan alone. Herein, we present final US and interim EU results comprising 506 treated subjects, 451 of which have completed the 1-year observation period and 20 ongoing. Age cohorts were as follows: 27 neonates/infants (0-<2 years), 128 children (2-<12 years), 54 adolescents (12-<16 years), and 285 adults (≥16 years)

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De Hooge, M., A. Ishchenko, S. Steinfeld, et al. "OP0055 MINIMAL RADIOGRAPHIC DAMAGE OF SACROILIAC JOINTS DETECTED IN PSORIATIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 37.1–37. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2392.

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Background:Psoriatic arthritis (PsA) is an inflammatory joint disease that is traditionally included in the Spondyloarthritis (SpA) spectrum. Prevalence and impact of axial involvement in PsA remains understudied but increasingly affects treatment decisions.Objectives:The first step, in this multi-purpose radiographic study, is to report on baseline radiographic damage of the sacroiliac joints (SIJ) in PsA patients from a prospective multicentre cohort study in private and academic rheumatology practices.Methods:Data from the Belgian Epidemiological Psoriatic Arthritis Study (BEPAS), a prospec

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