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Journal articles on the topic '347. 639 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Carter, Andrew, Gary W. Luck, and Simon P. McDonald. "Ecology of the red fox (Vulpes vulpes) in an agricultural landscape. 2. Home range and movements." Australian Mammalogy 34, no. 2 (2012): 175. http://dx.doi.org/10.1071/am11041.

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The red fox (Vulpes vulpes) is a major predator of Australian wildlife and livestock, but relatively few data exist on fox home-range size and movements in agricultural landscapes. We used radio-telemetry to measure variability in fox home-range size and overlap, and to quantify nightly movements in farmland in south-eastern Australia. Home-range estimates were calculated using the Minimum Convex Polygon (MCP) and Kernel Contours methods. Fourteen foxes were radio-tracked, with home-range size varying from 287 to 3574 ha (mean = 1177 ha, ±920 ha (s.d.), n = 10 foxes) based on the 100% MCP and

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Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XVII Hydrated 1 : 1 Adducts of 2,2′:6′,2″-Terpyridine with the Lanthanoid(III) Bromides and Some Binuclear Hydroxy-Bridged Dimers." Australian Journal of Chemistry 52, no. 6 (1999): 539. http://dx.doi.org/10.1071/ch98048.

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Room-temperature single-crystal X-ray structural characterizations are recorded for hydrated lan- thanoid(III) bromide/2,2′:6′,2″-terpyridine (tpy) (1 : 1) complexes, showing all to be ionic and of the form [(tpy)Ln(OH2)x]Br3.yH2O, where x and y are 6 and 1 for the isomorphous series Ln = La(-)Er (and intermediate members, by presumption), and 5 and various values for Ln = Tm, Yb, Lu. Crystals of [(tpy)Ln(OH2)6]Br3.H2O are monoclinic, P 21/c, a ≈ 8·5, b ≈ 18, c ≈ 16·3 Å, β ≈ 108°, Z = 4; for Ln = La, Er, conventional R values on |F| were 0·048, 0·080 for No 4027, 1347 ‘observed’ (I > 3σ(I))

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Borges, Lysandro Pinto, Aline Fagundes Martins, Mônica Santos de Melo, et al. "Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in Sergipe, Brazil." Revista Panamericana de Salud Pública 44 (October 6, 2020): 1. http://dx.doi.org/10.26633/rpsp.2020.108.

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Objective: To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population in the state of Sergipe, Brazil. Methods: This cross-sectional study with stratified sampling (sex and age) includeD serological immunofluorescent tests for IgM and IgG on samples from 3 046 asymptomatic individuals. Sample collection was performed in wet-markets of the 10 most populous cities of Sergipe, Brazil. Exclusion criteria included symptomatic individuals and health workers. The presence of comorbidities was registered. Results: Of the 3 046 participants, 1 577 (51.8%) were female and 1 469 (4

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Snehlata, Soni. "A NOVEL AND SIMPLE APPROCH TO SPECTROPHOTOMETRIC DETERMINATION OF PHOSPHATE IN SOFT-DRINKS." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES [FRTSSDS-18] (June 13, 2018): 47–51. https://doi.org/10.5281/zenodo.1288415.

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A simple spectrophotometric method is developed for the determination of phosphate in soft drinks samples like Pepsi cola, coke, and thums up. The method is based on the formation of phosphomolybdate with added molybdate followed by its reduction with stannous chloride in aqueous sulfuric acid medium. The system obeys Lambert-Beer’s law at 635 nm in the concentration range 0.3-12.24 ppm. Molar absorptive, correlation coefficient values were found to be 6.1x103 mol-1 cm,-1 0.999 mg cm-2 respectively. The results obtained were reproducible with acceptable standard deviation 3.7% and relati

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Guglielmelli, Paola, Giada Rotunno, Annalisa Pacilli, et al. "Differences in Clinical and Molecular Characteristics and Outcome in Prefibrotic and Overt Primary Myelofibrosis According to 2016 WHO Criteria. a Study on 639 Patients of the Agimm Group." Blood 128, no. 22 (2016): 943. http://dx.doi.org/10.1182/blood.v128.22.943.943.

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Abstract The revised 2016 World Health Organization (WHO) classification of myeloid neoplasms dictated distinct criteria for prefibrotic (prePMF) and overt primary myelofibrosis (PMF), based on bone marrow (BM) morphology, including fibrosis grade (G)<1 in prePMF and G2-3 in PMF, and presence of leukoerythroblastosis in PMF. AIM: to describe the characteristics and outcome of patients (pts) with a diagnosis of prePMF versus PMF according to the 2016 WHO criteria. METHODS. We used a database of ca 800 pts collected in 5 Italian tertiary centers of the AGIMM project. Pts annotated with diagno

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Uday, Suma, Semira Manaseki-Holland, Jessica Bowie, Mohamed Zulf Mughal, Francesca Crowe, and Wolfgang Högler. "The effect of vitamin D supplementation and nutritional intake on skeletal maturity and bone health in socio-economically deprived children." European Journal of Nutrition 60, no. 6 (2021): 3343–53. http://dx.doi.org/10.1007/s00394-021-02511-5.

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Abstract Purpose 1. To determine the effect of vitamin D supplementation on bone age (BA), a marker of skeletal maturity, and Bone Health Index (BHI), a surrogate marker of bone density. 2. To characterise the differences in nutritional intake and anthropometry between children with advanced vs. delayed BA. Methods The current study is a post hoc analysis of radiographs obtained as part of a randomised controlled trial. In this double-blind, placebo-controlled trial, deprived Afghan children (n = 3046) aged 1–11 months were randomised to receive six doses of oral placebo or vitamin D3 (100,000

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Yang, Mo, Huixia Deng, Liuming Yang, et al. "Coagulation Dysfunction and Hematological Changes in 633 Patients with COVID-19." Blood 136, Supplement 1 (2020): 22–23. http://dx.doi.org/10.1182/blood-2020-140274.

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Background: A previously unknown beta-coronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the international committee for the classification of viruses (ICTV). The disease caused by this virus was named as coronavirus disease 2019 (COVID-19). In addition to pulmonary manifestations, hematological changes such as lymphocytopenia, thrombocytopenia, and coagulation dysfunction can also be found in COVID-19 patients, and the mechanism is still unclear. Case

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Wang, Judy S., Martin Gutierrez, Drew W. Rasco, et al. "A phase 1 dose-escalation study to investigate the safety, efficacy, pharmacokinetics, and pharmacodynamic activity of cln-619 (Anti-MICA/B antibody) alone and in combination with pembrolizumab in patients with advanced solid tumors." Journal of Clinical Oncology 41, no. 16_suppl (2023): 2532. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2532.

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2532 Background: MICA and MICB are stress-induced ligands upregulated on the majority of human tumors. Engagement of MICA/B by the activating receptor NKG2D on NK cells and several subsets of T cells results in immune-mediated target cell lysis. However, proteases in the tumor microenvironment cleave cell surface MICA/B, enabling immune evasion. CLN-619 is a humanized MICA/B-specific IgG1 monoclonal antibody designed to prevent the proteolytic release of MICA/B, restoring immune-mediated tumor cell lysis. CLN-619 is expected to have broad anti-tumor activity. Methods: This phase 1, multicenter

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Alpizar-Rodriguez, D., F. Irazoque-Palazuelos, T. S. Rodriguez-Reyne, et al. "POS1242 FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS WITH RHEUMATIC DISEASES AND COVID-19 IN MEXICO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 904.1–904. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3342.

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Background:As of the 25th of January 2021, more than 150 thousand deaths as consequence of COVID-19 have been reported in Mexico [1]. Advanced age, male gender and comorbidities have been described as risk factors for severe disease and mortality in general population [2]. COVID-19 mortality in Mexican patients with rheumatic and musculoskeletal diseases (RMDs) is unknown.Objectives:To describe characteristics of Mexican patients with RMDs and COVID-19, and to analyse factors associated with mortality.Methods:The Global Rheumatology Alliance COVID-19 (GRA) physician reported registry, is an in

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Airoldi, C., V. Martire, M. S. Gálvez Elkin, et al. "POS0933 TREATMENT ACCESS AND ADHERENCE DURING SOCIAL PREVENTIVE AND MANDATORY ISOLATION IN ARGENTINIAN PATIENTS WITH SPONDYLARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 730.1–730. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3147.

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Background:Access to high-cost treatments is especially limited in low-resource countries. This issue is becoming stronger today given the health and economic crisis caused by the SARS-CoV2 pandemic. There are no reports in our country on limitations to access and adherence to treatment in patients with Spondyloarthritis (SpA) during social preventive and mandatory isolation.Objectives:Evaluate access and adherence to treatment in patients with Spondyloarthritis during social preventive and mandatory isolation.Methods:Patients with axial spondyloarthritis (axSpA) radiological (r-axSpA), non-ra

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Herrel, Lindsey A., Phyllis Yan, Parth Modi, Julia Adler-Milstein, Andrew M. Ryan, and John M. Hollingsworth. "Association of Medicare Beneficiary and Hospital Accountable Care Organization Alignment With Surgical Cost Savings." JAMA Health Forum 3, no. 12 (2022): e224817. http://dx.doi.org/10.1001/jamahealthforum.2022.4817.

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ImportanceAlthough Medicare accountable care organizations (ACOs) account for half of program expenditures, whether ACOs are associated with surgical spending warrants further study.ObjectiveTo assess whether greater beneficiary-hospital ACO alignment was associated with lower surgical episode costs.Design, Setting, and ParticipantsThis retrospective cohort study was conducted between 2020 and 2022 using US Medicare data from a 20% random sample of beneficiaries. Individuals 18 years of age and older and without kidney failure who had a surgical admission between 2008 and 2015 were included. F

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, Paloth Venugopalam, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. VI 4-Nitrophenoxides of Group 2." Australian Journal of Chemistry 51, no. 8 (1998): 775. http://dx.doi.org/10.1071/c97103.

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Room-temperature single-crystal X-ray structure determinations are recorded for 4-nitrophenolate (4-np-) salts of Group 2 metal ions, variously hydrated, M(4-np)2.xH2O, M = Mg, Ca, Sr, Ba. Mg(4-np)2.8H2 O is monoclinic, P21/c, a 12·402(3), b 6·673(7), c 11·833(6) Å, β 93·70(3)°, Z = 2; conventional R on |F| was 0·041 for No 1995 independent ‘observed’ (I > 3σ(I)) reflections. Ca(4-np)2.4H2O is monoclinic, P21/c, a 13·109(8), b 3·644(1), c 21·181(8) Å, β 125·55(3)°, Z= 2, R 0·050 for No 1371. Sr(4-np)2.8H2O is monoclinic, P21/n, a 7·934(1), b 10·658(1), c 23·602(2) Å, β 91·36(1)°, Z = 4, R 0

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Nyaguthii, Dickson Machira, Grieven P. Otieno, Ivy K. Kombe, et al. "Infection patterns of endemic human coronaviruses in rural households in coastal Kenya." Wellcome Open Research 6 (February 9, 2021): 27. http://dx.doi.org/10.12688/wellcomeopenres.16508.1.

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Background: The natural history and transmission patterns of endemic human coronaviruses are of increased interest following the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods: In rural Kenya 483 individuals from 47 households were followed for six months (2009-10) with nasopharyngeal swabs collected twice weekly regardless of symptoms. A total of 16,918 swabs were tested for human coronavirus (hCoV) OC43, NL63 and 229E and other respiratory viruses using polymerase chain reaction. Results: From 346 (71.6%) household members, 629 hCoV infection episodes were

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Edwards, Amy, Kevin Percival, Louisa Zouita, Jan Arevalo, and John Philip O'Dwyer. "ANALYSIS OF CONVULSIVE SEIZURES AT A DGH EMERGENCY DEPARTMENT." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 11 (2015): e4.129-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.4.

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IntroductionSeizures represent 3% of all emergency department attendances.MethodsA list of all possible seizure mimics was generated from ED computerized triage systems from 1/1/12 to 31/12/13. Data was extracted manually from review of ED notes and analyzed.Results905 seizure attendances by 636 patients were examined over 2 years. 340 men and 296 women accounted for them, with average age 33±28 years. 245 patients had a history of epilepsy and were taking at least one AED. >2 AEDs were used by 32 patients. 22 had known Non-Epileptic Attacks (NEAD). Convulsive seizures occurred in 429 and S

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Smith, Ian Edward, Dianne M. Finkelstein, Joyce O'Shaughnessy, et al. "Adjuvant lapatinib in women with early-stage HER2-positive breast cancer (HER2+ BC): Analysis of the hormone receptor-negative subgroup of the intent-to-treat (ITT) population of the TEACH trial." Journal of Clinical Oncology 30, no. 15_suppl (2012): 596. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.596.

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596 Background: TEACH is a randomized, double-blind, placebo (P)-controlled trial evaluating lapatinib (L) in reducing relapse risk in trastuzumab -naive patients (pts) previously treated with chemotherapy for HER2+ BC. The primary results (presented at SABCS 2011) showed a hazard ratio (HR) for disease-free survival (DFS) in L arm compared with P of 0.83 (95% confidence interval [CI] 0.70-1.00; stratified log-rank 2-sided P=.053). The predefined hormone receptor negative subgroup was analyzed, which in contrast to the hormone receptor positive subgroup of the ITT population (N=3147) had a sig

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Oztas, M., M. Bektaş, I. Karacan, et al. "AB1082 FREQUENCY AND SEVERITY OF COVID-19 IN PATIENTS WITH VARIOUS RHEUMATIC DISEASES TREATED REGULARLY WITH COLCHICINE OR HYDROXYCHLOROQUINE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1660.2–1661. http://dx.doi.org/10.1136/annrheumdis-2022-eular.83.

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BackgroundSeveral anti-inflammatory drugs which were targeted different mechanisms and investigated for both prevention and treatment for COVID-19.ObjectivesThe current study aimed to investigate whether patients regularly using colchicine or hydroxychloroquine (HCQ) have an advantage of protection from COVID-19 or developing less severe disease.MethodsPatients who were taking colchicine or HCQ regularly for a rheumatic disease including Familial Mediterranean Fever, Behçet’s syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis and Sjogren’s syndrome as well as their healthy household

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Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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Washirasaksiri, Chaiwat, Nutsakol Borrisut, Varisara Lapinee, et al. "Identification of pre-diabetes subphenotypes for type 2 diabetes, related vascular complications and mortality." BMJ Open Diabetes Research & Care 13, no. 3 (2025): e004803. https://doi.org/10.1136/bmjdrc-2024-004803.

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IntroductionPre-diabetes comprises diverse subphenotypes linked to varying complications, type 2 diabetes, and mortality outcomes. This study aimed to explore these outcomes across different pre-diabetes subphenotypes.Research design and methodsThe dataset included adults without type 2 diabetes with baseline HbA1c and fasting plasma glucose (FPG) measurements from Siriraj Hospital, Bangkok, Thailand. The participants were classified into six subphenotypes via thek-means clustering method on the basis of age, body mass index, FPG, HbA1c, high-density lipoprotein cholesterol and alanine aminotr

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Sand, David J., Burçin Mutlu-Pakdil, Michael G. Jones, et al. "Three Quenched, Faint Dwarf Galaxies in the Direction of NGC 300: New Probes of Reionization and Internal Feedback." Astrophysical Journal Letters 977, no. 1 (2024): L5. https://doi.org/10.3847/2041-8213/ad927c.

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Abstract We report the discovery of three faint and ultrafaint dwarf galaxies—Sculptor A, Sculptor B, and Sculptor C—in the direction of NGC 300 (D = 2.0 Mpc), a Large Magellanic Cloud–mass galaxy. Deep ground-based imaging with Gemini/GMOS resolves all three dwarf galaxies into stars, each displaying a red giant branch indicative of an old, metal-poor stellar population. No young stars or H i gas are apparent, and the lack of a GALEX UV detection suggests that all three systems are quenched. Sculptor C (D = 2.04 − 0.13 + 0.10 Mpc; M V = −9.1 ± 0.1 mag or L V = (3.7 − 0.3 + 0.4 ) × 105 L ⊙) is

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Lindstrot, R., R. Preusker, H. Diedrich, L. Doppler, R. Bennartz, and J. Fischer. "1D-Var retrieval of daytime total columnar water vapour from MERIS measurements." Atmospheric Measurement Techniques 5, no. 3 (2012): 631–46. http://dx.doi.org/10.5194/amt-5-631-2012.

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Abstract. A new scheme for the retrieval of total columnar water vapour from measurements of MERIS (Medium Resolution Imaging Spectrometer) on ENVISAT (ENVIronmental SATellite) is presented. The algorithm is based on a fast forward model of the water vapour transmittance around 900nm, including a correction for atmospheric scattering and the influence of the temperature- and pressure-profile on the water vapour absorption lines. It provides the water vapour column amount for cloud-free scenes above land and ocean at a spatial resolution of 0.25 km × 0.3 km and 1 km × 1.2 km, depending on wheth

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Jones, Hannah G., Rodrigo R. N. Rizzo, Brian W. Pulling, et al. "Adjunctive use of hypnosis for clinical pain: a systematic review and meta-analysis." PAIN Reports 9, no. 5 (2024): e1185. http://dx.doi.org/10.1097/pr9.0000000000001185.

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Abstract Systematic reviews suggest that stand-alone hypnotic suggestions may improve pain outcomes compared with no treatment, waitlist, or usual care. However, in clinical practice, hypnosis is often provided adjunctively with other interventions, which might have different effects than those reported in previous reviews. This systematic review aimed to summarize the analgesic effects of adjunctive hypnosis in adults with clinical pain. Seven databases (MEDLINE, Embase, PsycINFO, Emcare, SCOPUS, CENTRAL, Cochrane) were searched up to January 2024. Randomised controlled trials comparing the a

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, et al. "Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018." JAMA Network Open 5, no. 11 (2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify compl

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Fujii, Hisaki, Kevin She, Soudabeh Aslanian, et al. "Inflammatory Markers and Autoantibodies That Correlate with Early and Late Onset of New Onset Pediatric Chronic Graft-Versus-Host Disease (GVHD)." Blood 108, no. 11 (2006): 3232. http://dx.doi.org/10.1182/blood.v108.11.3232.3232.

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Abstract Chronic graft-vs-host disease (cGVHD) has previously been characterized by elevation of a number of inflammatory markers and autoantibodies. We hypothesized that evaluation of such markers would contribute to a biological classification of new onset cGVHD in children and possibly aid in early diagnosis. The COG study ASCT0031 is a phase III cGVHD therapeutic trial that included the biological evaluation of 52 newly diagnosed cGVHD pts and 34 time-matched post BMT control patients (2 – 18 yrs) with no clinical evidence of cGVHD. Chronic GVHD was divided into an early onset between 3 to

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Gandi, Carlo, Angelo Totaro, Riccardo Bientinesi, et al. "Purely Off-Clamp Partial Nephrectomy: Robotic Approach Better than Open Using a Pentafecta Outcome with Propensity Score Matching." Journal of Clinical Medicine 11, no. 21 (2022): 6241. http://dx.doi.org/10.3390/jcm11216241.

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Partial nephrectomy (PN) is the gold standard treatment for localized renal masses. Robot-assisted PN (RAPN) has overcome laparoscopy’s technical limitations, greatly expanding the indications of minimally invasive PN, which is dominated by renal artery clamping in almost all published series. We compared off-clamp RAPN (OFFC-RAPN) with the open approach (OFFC-OPN) using propensity score (PS) matching. A favourable pentafecta outcome was defined as a combination of no positive surgical margins (PSM), no complications of Clavien–Dindo (CD) grade ≥ 3, post-operative eGFR loss <10%, length of

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Sequist, Lecia V., James Chih-Hsin Yang, Nobuyuki Yamamoto, et al. "Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations." Journal of Clinical Oncology 31, no. 27 (2013): 3327–34. http://dx.doi.org/10.1200/jco.2012.44.2806.

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Purpose The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling from epidermal growth factor receptor (EGFR/ErbB1), human epidermal growth factor receptor 2 (HER2/ErbB2), and ErbB4 and has wide-spectrum preclinical activity against EGFR mutations. A phase II study of afatinib in EGFR mutation–positive lung adenocarcinoma demonstrated high response rates and progression-free survival (PFS). Patients and Methods In this phase III study, eligible patients with stage IIIB/IV lung

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Sequist, Lecia V., James Chih-Hsin Yang, Nobuyuki Yamamoto, et al. "Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations." Journal of Clinical Oncology 41, no. 16 (2023): 2869–76. http://dx.doi.org/10.1200/jco.22.02547.

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PURPOSE The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling from epidermal growth factor receptor (EGFR/ErbB1), human epidermal growth factor receptor 2 (HER2/ErbB2), and ErbB4 and has wide-spectrum preclinical activity against EGFR mutations. A phase II study of afatinib in EGFR mutation–positive lung adenocarcinoma demonstrated high response rates and progression-free survival (PFS). PATIENTS AND METHODS In this phase III study, eligible patients with stage IIIB/IV lung

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Nabak, Andrea C., Rachael Erin Johnson, Nicholas S. Keuler, and Karen E. Hansen. "Can a questionnaire predict vitamin D status in postmenopausal women?" Public Health Nutrition 17, no. 4 (2013): 739–46. http://dx.doi.org/10.1017/s1368980013001973.

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AbstractObjectiveOur objective was to determine whether a questionnaire can identify individuals with vitamin D insufficiency (VDI).DesignWomen completed the Vitamin D & Sun (VIDSUN) questionnaire and we measured their serum 25-hydrocyvitamin D (25(OH)D) levels. We assessed the sensitivity and specificity of the questionnaire to identify VDI (25(OH)D level <50 nmol/l).SettingClinical Research Unit, University of Wisconsin–Madison.SubjectsPostmenopausal women.ResultsWe recruited 609 postmenopausal women with a mean age of 61 (sd 6 years), of whom 113 (19 %) had VDI. Women with VDI were m

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Rescigno, Giuseppe, Sandeep Hothi, Christopher Bond, Mauin Uddin, Veena Bhatti, and John Stephen Billing. "CorMatrix Anterior Leaflet Augmentation of the Tricuspid Valve: Midterm Results." Heart Surgery Forum 24, no. 2 (2021): E261—E266. http://dx.doi.org/10.1532/hsf.3599.

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Background: Tricuspid annuloplasty is the most common surgical approach to correct tricuspid regurgitation (TR). In some patients, however, anterior leaflet patch augmentation may be necessary to optimize tricuspid competence. We reviewed our center cohort over the midterm and long term. Methods: From January 2013 to August 2018, 424 tricuspid valve procedures were performed, of which 420 were repairs and 4 were replacements. Indications were either isolated severe TR or moderate or greater TR, concomitant with other surgery. In the repair cohort, we identified those that had a patch augmentat

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Timmons, Brian W., Mazen J. Hamadeh та Mark A. Tarnopolsky. "No effect of short-term 17β-estradiol supplementation in healthy men on systemic inflammatory responses to exercise". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, № 2 (2006): R285—R290. http://dx.doi.org/10.1152/ajpregu.00605.2005.

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Sex-based differences in inflammatory responses to exercise may be mediated by estrogen through increased muscle membrane stability and/or inhibited cytokine production. In this study, in vivo effects of estrogen on systemic inflammation-related responses to exercise were assessed in healthy men. In a double-blind, placebo-controlled, crossover design, 11 men cycled for 90 min at 65% V̇o2 maxafter 8 days of 17β-estradiol supplementation (ES; 2 mg/day) or placebo (PL; glucose polymer). After a 2-wk washout, exercise was repeated after 8 days on the alternate treatment. Blood was collected pre-

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Snyder, Megan Lian, Eirwen Murray Miller, Liliana Cruz, Jessica DeLeeuw, Emily Snell, and Nujsaubnusi Cassandra Vue. "Preoperative Diagnostic Evaluation in Patients Undergoing Hysterectomy and the Incidence of Incidental Diagnosis of Gynecologic Malignancy: A Single-Institution Experience in a Tertiary Care Setting [ID 1663]." Obstetrics & Gynecology 145, no. 6S (2025): 10S. https://doi.org/10.1097/aog.0000000000005916.033.

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INTRODUCTION: The incidence of endometrial cancer diagnosis after a benign hysterectomy is reported to be very rare. Delayed cancer diagnosis may result in additional surgery, delayed adjuvant therapy, and poorer patient outcomes. The objective of this study is to assess the incidence of incidental diagnosis of endometrial cancer and trends in preoperative evaluation of hysterectomies in a high-volume tertiary care setting. METHODS: Patients aged 18–100 who underwent a hysterectomy for benign indication between January 1, 2022, and December 31, 2022, were included. Exclusion criteria were hyst

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Zhang, Lingyun, Xiujuan Qu, Yuee Teng, et al. "Efficacy of Thalidomide in Preventing Delayed Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase III Trial (CLOG1302 study)." Journal of Clinical Oncology 35, no. 31 (2017): 3558–65. http://dx.doi.org/10.1200/jco.2017.72.2538.

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Purpose We examined the efficacy and safety of thalidomide (THD) for the prevention of delayed nausea and vomiting in patients who received highly emetogenic chemotherapy (HEC). Patients and Methods In a randomized, double-blind, active-controlled, phase III trial, chemotherapy-naive patients with cancer who were scheduled to receive HEC that contained cisplatin or cyclophosphamide-doxorubicin/epirubincin ≥ 50 mg/m2 regimens were randomly assigned to a THD group (100 mg twice daily on days 1 to 5) or placebo group, both with palonosetron (0.25 mg on day 1) and dexamethasone (12 mg on day 1; 8

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Kufeldt, Johannes, Marketa Kovarova, Michael Adolph, et al. "Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening." Experimental and Clinical Endocrinology & Diabetes 126, no. 02 (2017): 123–29. http://dx.doi.org/10.1055/s-0043-112653.

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Abstract Objective Diabetes mellitus affects almost one in 10 individuals in Germany. So far, little is known about the diabetes prevalence in maximum care hospitals. We assessed the diabetes prevalence, proportion of undiagnosed cases, the effectiveness of diabetes screening in a university hospital, the consequences for hospital stay and acquired complications. Research Design and Methods Over a 4 week period we determined HbA1c from 3 733 adult patients which were hospitalized at the university hospital of Tuebingen and had an available blood sample. Diabetes diagnosis was defined as HbA1c≥

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Krzywicka, Katarzyna, Anita van de Munckhof, Mayte Sánchez van Kammen, et al. "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination." Neurology 98, no. 7 (2021): e759-e768. http://dx.doi.org/10.1212/wnl.0000000000013148.

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Background and ObjectivesCerebral venous sinus thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.MethodsWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of a first dose of 4 SARS-CoV-2 vaccinations using data from the Europea

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Hwang, Gyojun, Chang Wan Oh, Jae Seung Bang, et al. "Superficial Temporal Artery to Middle Cerebral Artery Bypass in Acute Ischemic Stroke and Stroke in Progress." Neurosurgery 68, no. 3 (2011): 723–30. http://dx.doi.org/10.1227/neu.0b013e318207a9de.

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Abstract BACKGROUND: Surgical reperfusion may be beneficial in patients with acute ischemic stroke who are ineligible for thrombolysis. OBJECTIVE: To evaluate the outcome of superficial temporal artery to middle cerebral artery (STA-MCA) bypass in acute stroke and stroke in progress. METHODS: The clinical and radiological data of 9 patients treated by STA-MCA bypass requiring urgent reperfusion but ineligible for intra-arterial thrombolysis (IAT) were reviewed. Pooled analysis was performed of published literature concerning STA-MCA bypass in acute stroke (21 cases in 2 articles). RESULTS: Of

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Kuźmicz, Agnieszka, Arti Goyal, Stanisław Zola, et al. "Optical Variability of Eight FRII-type Quasars with 13 yr Photometric Light Curves." Astrophysical Journal Supplement Series 263, no. 1 (2022): 16. http://dx.doi.org/10.3847/1538-4365/ac9622.

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Abstract We characterize the optical variability properties of eight lobe-dominated radio quasars (QSOs): B2 0709+37, FBQS J095206.3+235245, PG 1004+130, [HB89] 1156+631, [HB89] 1425+267, [HB89] 1503+691, [HB89] 1721+343, and 4C +74.26, systematically monitored for a duration of 13 yr since 2009. The quasars are radio-loud objects with extended radio lobes that indicate their orientation close to the sky plane. Five of the eight QSOs are classified as giant radio quasars. All quasars showed variability during our monitoring, with magnitude variations between 0.3 and 1 mag for the least variabl

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Salomon, N., M. Marom, S. Odeh, et al. "P1138 Curcumin-QingDai combination for patients with active Crohn’s disease: Initial real-world experience from a retrospective multi-center cohort study." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i2084. https://doi.org/10.1093/ecco-jcc/jjae190.1312.

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Abstract Background A combination of Curcumin and QingDai (CurQD) was shown to exert aryl-hydrocarbon-receptor (AhR) pathway activation and to be effective in ulcerative colitis. However, its benefit in Crohn’s disease (CD) has not been studied Methods A retrospective cohort study of patients with active CD treated with CurQD at three academic centers. Active disease was defined by PRO-2 SF≥2 and AP ≥1. The primary endpoint was the rate of clinical remission at the end-of-induction (weeks 8-12), PRO2 SF≤1 and AP=0. Secondary endpoints included biomarker response (FCP drop ≥50% in a patient wit

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Yang, James Chih-Hsin, Martin H. Schuler, Nobuyuki Yamamoto, et al. "LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations." Journal of Clinical Oncology 30, no. 18_suppl (2012): LBA7500. http://dx.doi.org/10.1200/jco.2012.30.18_suppl.lba7500.

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LBA7500 Background: Afatinib (A) is a selective, orally bioavailable, irreversible ErbB family blocker of EGFR (ErbB1), HER2 (ErbB2), and ErbB4. This global study investigated the efficacy and safety of A compared with pemetrexed/cisplatin (PC) in pts with EGFR mutation positive advanced lung adenocarcinoma. Methods: Following central testing for EGFR mutations (companion diagnostic TheraScreen EGFR RGQ PCR kit), 345 pts (stage IIIB/IV, PS 0–1, chemo-naive) were randomized 2:1 (A: 230; PC: 115) to daily A 40 mg or iv PC (500 mg/m2 + 75 mg/m2 q21 days up to 6 cycles). Primary endpoint was progr

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Acapovi, Geneviève L., Y. Yao, E. N'Goran, Mamadou Lamine Dia, and Marc Desquesnes. "Abondance relative des tabanidés dans la région des savanes de Côte d'Ivoire." Revue d’élevage et de médecine vétérinaire des pays tropicaux 54, no. 2 (2001): 109. http://dx.doi.org/10.19182/remvt.9788.

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L'existence, l'abondance, la dynamique saisonnière, les préférences écologiques et la diversité des espèces de tabanidés ont été évaluées par des captures d'insectes à l'aide de pièges Nzi. L'étude a été menée durant quatre saisons dans quatre types de sites (savane, forêt, galerie et parc) et dans quatre localités des deux principaux départements d'élevage du nord et du nordouest de la Côte d'Ivoire, Odienné et Korhogo. Seize espèces de tabanidés appartenant à quatre genres ont été identifiées pour un total de 3 104 spécimens capturés. Les espèces numériquement les plus abondantes ont été Tab

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Kantathut, Narongrit, Piya Cherntanomwong, Siam Khajarern, and Parinya Leelayana. "Lactated Ringer’s as a Base Solution for del Nido Cardioplegia." Journal of ExtraCorporeal Technology 51, no. 3 (2019): 153–59. http://dx.doi.org/10.1051/ject/201951153.

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Unavailability of Plasma-Lyte A precludes the utility of traditional del Nido cardioplegia in many countries. This observational study aimed to evaluate myocardial preservation and clinical outcomes when using lactated Ringer’s solution as the base solution for del Nido cardioplegia as compared with our institute’s standard blood cardioplegia strategy. Eighty-nine adult patients underwent cardiac surgery for acquired heart disease from February 2017 to November 2017 either with del Nido cardioplegia (n = 44) or blood cardioplegia (n = 45). Clinical data and outcomes were compared. Patient char

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Sesin, C., G. Gallo, A. Gellett, et al. "POS1033 SAFETY OF IXEKIZUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS: AN INTEGRATED ANALYSIS OF 4 CLINICAL TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 789.1–789. http://dx.doi.org/10.1136/annrheumdis-2021-eular.567.

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Background:Patients with psoriatic arthritis (PsA) require long-term treatment, which may lead to adverse events (AEs). Ixekizumab, an interleukin-17A antagonist, is approved for the treatment of adults with active PsA.Objectives:We report a summary of safety outcomes for patients enrolled in 4 PsA studies with up to 3 years of exposure to ixekizumab.Methods:This integrated safety analysis included all patients with PsA who received at least 1 dose of ixekizumab (80 mg every 2 or 4 weeks) in 4 clinical trials (NCT01695239, NCT02349295, NCT02584855, NCT03151551). Safety outcomes included treatm

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Fretheim, Atle, Ingeborg Hess Elgersma, Arnfinn Helleve, Petter Elstrøm, Oliver Kacelnik, and Lars G. Hemkens. "Effect of Wearing Glasses on Risk of Infection With SARS-CoV-2 in the Community." JAMA Network Open 5, no. 12 (2022): e2244495. http://dx.doi.org/10.1001/jamanetworkopen.2022.44495.

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ImportanceObservational studies have reported an association between the use of eye protection and reduced risk of infection with SARS-CoV-2 and other respiratory viruses, but, as with most infection control measures, no randomized clinical trials have been conducted.ObjectivesTo evaluate the effectiveness of wearing glasses in public as protection against being infected with SARS-CoV-2 and other respiratory viruses.Design, Setting, and ParticipantsA randomized clinical trial was conducted in Norway from February 2 to April 24, 2022; all adult members of the public who did not regularly wear g

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Danese, S., A. Dignass, D. Laharie, et al. "OP34 Mirikizumab demonstrates rapid improvements in bowel urgency severity, bowel urgency frequency, and stool deferral time in patients with moderately-to-severely active Ulcerative Colitis: 12-week interim results from the phase 3b LUCENT-URGE trial." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i68. https://doi.org/10.1093/ecco-jcc/jjae190.0034.

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Abstract Background Bowel urgency (BU) is a common, under-recognized and debilitating symptom among patients with ulcerative colitis (UC). LUCENT-URGE is a Phase 3b, open-label, single-arm 28-week (W) study in adults with moderately-to-severely active UC and BU (Urgency Numeric Rating Scale [UNRS] ≥3) at baseline treated with mirikizumab (MIRI) (NCT05767021). BU was assessed using the validated UNRS1 and 2 new BU assessments: BU Frequency (BUF) and Stool Deferral Time (SDT). These 3 BU measures (UNRS, BUF, SDT) and clinical endpoints provide a more comprehensive understanding of BU and the imp

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Podzolkov, V. I., and A. I. Tarzimanova. "Endothelial function changes in paroxysmal atrial fibrillation and treatment with propafenone." Cardiovascular Therapy and Prevention 17, no. 4 (2018): 40–45. http://dx.doi.org/10.15829/1728-8800-2018-4-40-45.

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Aim. To evaluate the changes of endothelial function in arterial hypertension (AH) patients with paroxysmal atrial fibrillation (AF) in treatment with propafenone (Propanorm, PRO.MED.CS Praha a. s.) in comparison with bisoprolol.Material and methods. To the study, 62 AH patients included with paroxysmal AH, age 45-63 y. o. (mean age 54,5±3,7 y. o.). Patients were randomized to 2 groups: 32 of group 1 (main) for rhythm-control were taking propafenone (Propanorm, PRO.MED.CS Praha a. s.) 450 mg daily, and 30 of group 2 (comparison) were taking bisoprolol for rate control. The groups were comparab

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Adwer, Lina, Taylor Nelson, Kristy Carlson, et al. "Evaluating Hypoglossal Nerve Stimulation Outcomes in Obstructive Sleep Apnea: Impact of Predisposing Conditions in a Retrospective Cohort." International Journal of Medical Students 13, no. 2 (2025): 182–86. https://doi.org/10.5195/ijms.2025.2796.

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Background: This retrospective study aimed to analyze treatment outcomes for patients receiving a hypoglossal nerve stimulation (HNS) device for obstructive sleep apnea (OSA). Methods: Chart reviews were conducted for HNS patients who underwent a post-implantation polysomnography (PSG) (typically performed approximately 2 months after device activation) to assess therapeutic response and optimize stimulation settings. Patients were categorized into “green (GP)” (optimal response: AHI <15, ≥4 hours/night device use, and subjective benefit) and “yellow (YP)” (suboptimal response: failure to m

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Bassat, Quique, Dianna M. Blau, Ikechukwu Udo Ogbuanu, et al. "Causes of Death Among Infants and Children in the Child Health and Mortality Prevention Surveillance (CHAMPS) Network." JAMA Network Open 6, no. 7 (2023): e2322494. http://dx.doi.org/10.1001/jamanetworkopen.2023.22494.

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ImportanceThe number of deaths of children younger than 5 years has been steadily decreasing worldwide, from more than 17 million annual deaths in the 1970s to an estimated 5.3 million in 2019 (with 2.8 million deaths occurring in those aged 1-59 months [53% of all deaths in children aged &amp;lt;5 years]). More detailed characterization of childhood deaths could inform interventions to improve child survival.ObjectiveTo describe causes of postneonatal child deaths across 7 mortality surveillance sentinel sites in Africa and Asia.Design, Setting, and ParticipantsThe Child Health and Mortal

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De Montalembert, Mariane, Frédéric Galacteros, Jean Antoine Ribeil, et al. "Implementation of a European Cohort to Follow Sickle Cell Children and Adults Treated with Hydroxycarbamide." Blood 124, no. 21 (2014): 564. http://dx.doi.org/10.1182/blood.v124.21.564.564.

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Abstract Hydroxycarbamide (HU) is a myelosuppressive drug marketed since 1968 for the treatment of hematological cancer, and authorized since 2007 in Europe as orphan medicinal product for the prevention of recurrent vaso-occlusive crises including acute chest syndrome in adults and children older than 2 years with sickle cell disease (SCD). ESCORT-HU (European Sickle Cell Disease Cohort – Hydroxyurea) is a multicenter prospective non interventional study implemented in Europe to collect more information about the safety profile of HU and morbi-mortality in SCD patients treated with HU. The st

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Barsouk, Adam, Omar Elghawy, Jonathan Henry Sussman, Jessica Xu, Ronac Mamtani, and Lin Mei. "Survival disparities by race in advanced urothelial carcinoma (aUC): A real-world analysis." Journal of Clinical Oncology 43, no. 5_suppl (2025): 668. https://doi.org/10.1200/jco.2025.43.5_suppl.668.

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668 Background: Retrospective population data suggest poorer survival for non-White aUC patients. However, data on survival disparities in the era of immuno- and targeted therapies is limited. Methods: This cohort study used Flatiron Health’s nationwide de-identified electronic health record (EHR)-derived database. 7,244 patients (pts) were identified. Pts who started systemic therapy for aUC from 1/1/2017 to 5/1/2024 and had a recorded race were included. Baseline demographics, including social determinants of health (SDOH) score, performance status (PS), disease characteristics, treatment hi

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Tomizawa, Daisuke, Akio Tawa, Tomoyuki Watanabe, et al. "Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)." Blood 120, no. 21 (2012): 2615. http://dx.doi.org/10.1182/blood.v120.21.2615.2615.

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Abstract Abstract 2615 Background: Infants (age <1 year) with AML are naturally vulnerable to intensive cytotoxic therapy, and we have previously reported unacceptably high early death rate mainly due to pulmonary complications among the first 32 infants (28 eligible) enrolled in the JPLSG AML-05 study, which prompted us to suspension of patient accrual and protocol amendment (Tomizawa D. 52ndASH abstract #2146). Seventeen additional infants were enrolled after the amendment, and here we report the final outcome of total 45 infants with AML treated on AML-05 study. Patients & Methods: J

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