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Journal articles on the topic '347:656.7 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Davies, M. A., A. Y. Bedikian, S. McIntyre, et al. "Natural history of metastatic melanoma patients with CNS metastases." Journal of Clinical Oncology 24, no. 18_suppl (2006): 8054. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.8054.

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8054 Background: Melanoma has a high rate of CNS metastasis (mets). The objective of this study was to evaluate the characteristics and outcomes of melanoma patients (pts) who develop CNS mets. Methods: 333 pts with a diagnosis of CNS mets were identified from databases of 743 chemotherapy naïve metastatic melanoma (MM) pts enrolled on clinical trials between 1986 and 2004. Their clinical and pathological characteristics were reviewed. Results: The site of primary melanoma was head or neck (60/333; 18%), trunk/abdomen (144/333; 43%), limbs (66/333; 20%), ocular (2/333; 1%), or unknown (61/333;

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Gamage, Janaka P., Angela P. De Silva, Arjan K. Nalliah, and Stuart D. R. Galloway. "Effects of Dehydration on Cricket Specific Skill Performance in Hot and Humid Conditions." International Journal of Sport Nutrition and Exercise Metabolism 26, no. 6 (2016): 531–41. http://dx.doi.org/10.1123/ijsnem.2016-0015.

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The aim of the current study was to assess the effects of dehydration on cricket specific motor skill performance among fast-bowlers, fielders, and batsmen playing in a hot and humid environment. 10 fast-bowlers, 12 fielders and 8 batsmen participated in two field trials conducted 7 days apart: a fluid provision trial (FP) and a fluid restriction trial (FR). Each trial consisted of a 2-hr standardized training session and pretraining and posttraining skill performance assessments. Bowling speed and accuracy (line and length), throwing speed and accuracy (overarm, sidearm and underarm) and time

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Parker, Pablo M., Ryotaro Nakamura, Vinod Pullarket, et al. "Analysis of Predictive Power of Prednisone Dose at 3 Months of Treatment on CGVHD Prognosis." Blood 110, no. 11 (2007): 1975. http://dx.doi.org/10.1182/blood.v110.11.1975.1975.

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Abstract Current CGVHD prognostic and staging systems are still undergoing development and have identified plt count; CGVHD types progressive(P), quiescent(Q), de novo(DN); KPS, and GI involvement as significant risk factors affecting outcome. A simple reproducible staging system such as used for AGVHD to apply in clinical trials is still lacking. We evaluated whether the PSE dose required to control CGVHD at 3 months from diagnosis would have a prognostic effect on survival and in and of itself serve as a criteria for secondary intervention or investigational therapy. We hypothesized that by

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Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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Sierra-Díaz, Diana Carolina, Adrien Morel, Dora Janeth Fonseca, et al. "Abstract P3-07-05: Genetic profile of germline mutations in unselected women with breast cancer in a Colombian population." Cancer Research 82, no. 4_Supplement (2022): P3–07–05—P3–07–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-07-05.

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Abstract Introduction In Colombia Breast cancer (BC), is the most frequent and has the highest mortality rate among all types of cancer. There are few studies of the genomic profile in unselected affected population by BC in Colombia. Some of these studies have only tested the presence of variants reported as founders named “Colombian Profile”.We conducted a large-scale genomic analysis using Whole Exome Sequencing (WES) to evaluate germline mutations in unselected BC patients. Methods This trial included 299 unselected BC female patients aged over 18 years old, without personal and family his

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Streng, Alexander S., Thijs S. R. Delnoij, Mark M. G. Mulder, et al. "Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO." TH Open 04, no. 04 (2020): e365-e375. http://dx.doi.org/10.1055/s-0040-1719083.

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Abstract Objective Severe cases of coronavirus disease 2019 (COVID-19) can require continuous renal replacement therapy (CRRT) and/or extracorporeal membrane oxygenation (ECMO). Unfractionated heparin (UFH) to prevent circuit clotting is mandatory but monitoring is complicated by (pseudo)-heparin resistance. In this observational study, we compared two different activated partial thromboplastin time (aPTT) assays and a chromogenic anti-Xa assay in COVID-19 patients on CRRT or ECMO in relation to their UFH dosages and acute phase reactants. Materials and Methods The aPTT (optical [aPTT-CS] and/

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Böhrer, M., E. Fitzpatrick, K. Hurley, et al. "LO47: Hematochezia in children with acute gastroenteritis in the emergency department: clinical phenotype, etiologic pathogens, and resource utilization." CJEM 22, S1 (2020): S24. http://dx.doi.org/10.1017/cem.2020.102.

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Introduction: Acute bloody diarrhea obligates rapid and accurate diagnostic evaluation; few studies have described such cohorts of children. Methods: We conducted a planned secondary analysis employing the Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE) acute gastroenteritis study cohort to describe the characteristics of children with acute bloody diarrhea, compared to a cohort of children without hematochezia. Children <18 years of age presenting to 2 pediatric tertiary care emergency departments (EDs) in Alberta, with ≥3 episodes of diarrhea and/or vomiting in the precedin

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Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis

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Denton, Alicia N., Caroline G. Lucas, Timothy J. Safranski, et al. "83 Body weight from birth to 260 days of age for pigs with functional deletions in growth hormone receptor (GHR) promoters created using CRISPR/Cas9 gene editing." Journal of Animal Science 103, Supplement_1 (2025): 197–98. https://doi.org/10.1093/jas/skaf102.215.

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Abstract Growth hormone controls animal growth, lactation, and reproduction. The actions of GH are dependent on the GHR. Two promoter complexes control GHR expression. The GHRP1 controls the liver-specific inducible expression of the GHR1A mRNA. The GHRP2 controls the non-tissue specific constitutive expression of GHR1B mRNA. The objective was to test the functional significance [effect on body weight (BW)] of each GHR promoter by using genetically modified pigs. The CRISPR/Cas9 system was used to delete GHRP1 and GHRP2 in fetal fibroblasts that were cloned to create two independent lines for

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Rochat, T. J., B. Houle, A. Stein, R. M. Pearson, M. L. Newell, and R. M. Bland. "Psychological morbidity and parenting stress in mothers of primary school children by timing of acquisition of HIV infection: a longitudinal cohort study in rural South Africa." Journal of Developmental Origins of Health and Disease 9, no. 1 (2017): 41–57. http://dx.doi.org/10.1017/s204017441700068x.

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Longitudinal maternal mental health data are needed from high HIV prevalence settings. The Siyakhula Cohort (SC) is a population-based cohort of HIV-positive and negative mothers (n=1506) with HIV-negative children (n=1536) from rural South Africa. SC includes 767 HIV-negative mothers; 465 HIV-positive in pregnancy; 272 HIV-positive since pregnancy (n=2 missing HIV status). A subgroup (n=890) participated in a non-randomized breastfeeding intervention [Vertical Transmission Study (VTS)]; the remaining (n=616) were resident in the same area and received antenatal care at the time of the VTS, bu

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Al-Khazraji, Khalid Abdulla, Wissam Khudhair Abbas, and Safiya Khalid Abdullah. "Prevalence and Risk Factors for Transmission and Genotype of HCV in Iraqi Patients." Global Journal of Health Science 11, no. 12 (2019): 185. http://dx.doi.org/10.5539/gjhs.v11n12p185.

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BACKGROUND: Hepatitis C virus (HCV) infection is a serious public health problem in the world, and about 170 million patients are chronically infected with HCV. Worldwide; different epidemiologic patterns of HCV infection have been identified.  AIM OF THE STUDY: By this study, we try to know the prevalence and risk factors for HCV transmission in Iraqi patients and genotype distribution of the disease.  PATIENTS &amp; METHODS: In a cross sectional study of 355898 persons, 232645 males &amp; 123253 females; had been enrolled for the study in Baghdad teaching hosp

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Pedersen, J. K., K. Andersen, A. J. Svendsen, and K. Hørslev-Petersen. "THU0145 INDICATIONS AND INCIDENCE OF TREATMENT WITH ANTIDEPRESSANTS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND MATCHED CONTROLS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 288.2–288. http://dx.doi.org/10.1136/annrheumdis-2020-eular.976.

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Background:The incidence of depression is about 1.5-2 times higher in patients with rheumatoid arthritis (RA) versus controls. (1, 2) Previous data on treatment with antidepressants has pointed to an almost equal distribution of indications between depression and other indications. (3)Objectives:To describe and compare indications and the incidence of treatment with antidepressants in patients with RA and matched controls.Methods:The study involved an inception cohort of patients with incident RA ascertained from 1995 to 2002 according to the American College of Rheumatology 1987 classificatio

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Lucas, C., S. Rodriguez, R. Jean, et al. "AB0034 EARLY IMMUNIZATION AGAINST TREATMENT IS ASSOCIATED TO POOR CLINICAL RESPONSE AT 6 MONTHS AND LOW NUMBER OF TRANSITIONAL B CELLS AT BASELINE IN RHEUMATOID ARTHRITIS PATIENTS TREATED BY ADALIMUMAB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1319.1–1320. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3938.

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Background:Circulating anti-drug antibodies (ADAs) are detectable approximatively in 33% of adalimumab treated rheumatoid arthritis (RA) patients, often within the first 6 months of therapy1-2. Classically, circulating ADAs associate with their specific drugs to form immune complexes, increasing drug clearance, and by this mechanism reducing therapeutic effect3. B cell involvement leading to ADAs production is not yet well established.Objectives:To study early ADAs formation according to clinical response to an adalimumab therapy in RA patients and the relationship between ADAs and circulating

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Self, Wesley H., Matthew S. Shotwell, Kevin W. Gibbs, et al. "Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19." JAMA 329, no. 14 (2023): 1170. http://dx.doi.org/10.1001/jama.2023.3546.

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ImportancePreclinical models suggest dysregulation of the renin-angiotensin system (RAS) caused by SARS-CoV-2 infection may increase the relative activity of angiotensin II compared with angiotensin (1-7) and may be an important contributor to COVID-19 pathophysiology.ObjectiveTo evaluate the efficacy and safety of RAS modulation using 2 investigational RAS agents, TXA-127 (synthetic angiotensin [1-7]) and TRV-027 (an angiotensin II type 1 receptor–biased ligand), that are hypothesized to potentiate the action of angiotensin (1-7) and mitigate the action of the angiotensin II.Design, Setting,

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Bakaloudi, Dimitra Rafailia, Rafee Talukder, Dimitrios Makrakis, et al. "Role of tumor mutational burden (TMB) and microsatellite instability (MSI) in patients (pts) with advanced urothelial carcinoma (aUC) treated with immune checkpoint inhibitor (ICI)." Journal of Clinical Oncology 42, no. 4_suppl (2024): 654. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.654.

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654 Background: MSI and TMB correlate with ICI efficacy. We assessed the association between TMB and MSI with outcomes in pts with aUC treated with anti-PD1/L1 in a ‘real-world’ cohort. We hypothesize that pts with high TMB and MSI-high (H) have better outcomes with ICI. Methods: In this retrospective study we included pts from 13 sites treated with ICI for aUC. We calculated overall response rate (ORR), median overall and progression-free survival (mOS, mPFS) using KM method from ICI start. TMB and MSI were assessed by NGS. TMB was analyzed as dichotomous (≥10 vs <10 mut/Mb) and continuous

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Shih, Lauren C., David Kaplan, Larry W. Kraiss, et al. "Circulating Platelet-Monocyte Aggregates Predict Venous Thromboembolism in Older Adults Undergoing Major Orthopedic Surgery." Blood 126, no. 23 (2015): 2308. http://dx.doi.org/10.1182/blood.v126.23.2308.2308.

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Abstract Background: Improvements in the early identification of older patients with a high post-operative VTE risk would potentially translate into more effective VTE prevention and management strategies. Objectives: We sought to establish whether measuring early indices of in vivo platelet activation following orthopedic surgery predicted VTE in older patients. Methods: We performed a prospective cohort study in 32 patients undergoing elective hip or knee arthroplasty who received warfarin thromboprophylaxis post-operatively. Patients were assessed for deep vein thrombosis post-operatively b

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CLARK, WILLIAM R., JOHN K. LEYPOLDT, LEE W. HENDERSON, BRUCE A. MUELLER, MERI KAY SCOTT, and EDWARD F. VONESH. "Quantifying the Effect of Changes in the Hemodialysis Prescription on Effective Solute Removal with a Mathematical Model." Journal of the American Society of Nephrology 10, no. 3 (1999): 601–9. http://dx.doi.org/10.1681/asn.v103601.

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Abstract. One potential benefit of chronic hemodialysis (HD) regimens of longer duration or greater frequency than typical three-times-weekly schedules is enhanced solute removal over a relatively wide molecular weight spectrum of uremic toxins. This study assesses the effect of variations in HD frequency (F: per week), duration (T: min per treatment), and blood/dialysate flow rates (QB/QD: ml/min) on steady-state concentration profiles of five surrogates: urea (U), creatinine (Cr), vancomycin (V), inulin (I), and β2-microglobulin (β2M). The regimens assessed for an anephric 70-kg patient were

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Yamaguchi, Kensei, Satoru Iwasa, Motohiro Hirao, et al. "Phase 1 study of the liposomal formulation of eribulin (E7389-LF): Results from the advanced gastric cancer expansion cohort." Journal of Clinical Oncology 39, no. 15_suppl (2021): 4025. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4025.

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4025 Background: Eribulin has proven efficacy in previously treated metastatic breast cancer and liposarcoma. E7389-LF is a new formulation that uses liposomes to encapsulate eribulin, which is anticipated to improve eribulin concentration in tumor tissues. In the dose-expansion part of a phase 1 study of E7389-LF, the safety profile was acceptable and 2 patients (pts) out of 10 with gastric cancer (GC) had an objective response. Thus, the GC cohort was expanded for further evaluation. Here, we report efficacy and safety data from the phase 1 expansion cohort of pts with advanced GC who were t

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Oztas, M., M. Bektaş, I. Karacan, et al. "AB1082 FREQUENCY AND SEVERITY OF COVID-19 IN PATIENTS WITH VARIOUS RHEUMATIC DISEASES TREATED REGULARLY WITH COLCHICINE OR HYDROXYCHLOROQUINE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1660.2–1661. http://dx.doi.org/10.1136/annrheumdis-2022-eular.83.

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BackgroundSeveral anti-inflammatory drugs which were targeted different mechanisms and investigated for both prevention and treatment for COVID-19.ObjectivesThe current study aimed to investigate whether patients regularly using colchicine or hydroxychloroquine (HCQ) have an advantage of protection from COVID-19 or developing less severe disease.MethodsPatients who were taking colchicine or HCQ regularly for a rheumatic disease including Familial Mediterranean Fever, Behçet’s syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis and Sjogren’s syndrome as well as their healthy household

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Kodali, Murali, James Shortridge, and Donald Doll. "Severe Hemolysis in Systemic Loxoscelism." Blood 124, no. 21 (2014): 4871. http://dx.doi.org/10.1182/blood.v124.21.4871.4871.

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Abstract Introduction: Brown recluse spider bites are encountered commonly in endemic areas of North and South America. Loxosceles reclusa is the species of Loxosceles most commonly seen in the states of MO, KS, OK, TX, AK, LA, KY, TN, MS, AL and parts of IL, IA, IN and GA. The incidence of hemolytic anemia with systemic loxoscelism in the USA seems to be significantly higher and more severe than the incidence and severity reported in studies from South America (13%-15% incidence). In our 6 cases of loxoscelism associated with severe hemolysis, we noticed that there are signs and symptoms that

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Churuangsuk, Chaitong, Julien Hall, Andrew Reynolds, Simon J. Griffin, Emilie Combet, and Michael E. J. Lean. "Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission." Diabetologia 65, no. 1 (2021): 14–36. http://dx.doi.org/10.1007/s00125-021-05577-2.

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Abstract Aims/hypothesis Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated dietary approaches for weight loss, and remission, in people with type 2 diabetes to inform practice and clinical guidelines. Methods First, we conducted a systematic review of published meta-analyses of RCTs of weight-loss diets. We searched MEDLINE (Ovid), PubMed, Web of Science and Cochrane Database of Systematic Reviews, up to 7 May 2021. We synthesised weight loss findings stratified by

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Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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Jones, BA, RA How, and DJ Kitchener. "A field study of Pseudocheirus occidentalis (Marsupialia : Petauridae) II. Population studies." Wildlife Research 21, no. 2 (1994): 189. http://dx.doi.org/10.1071/wr9940189.

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Field studies of the rare and endangered western ringtail possum (Pseudocheirus occidentalis) were undertaken at five main sites in south-western Australia. Population studies employing capture-markrelease and telemetry methods were concentrated at Abba River and Locke Estate, near Busselton, and supplementary telemetry records were obtained for three females at Yendicup, Perup, near Manjimup. The location of dreys and sightings were mapped at Geographe Bay (near Busselton) and Emu Point (Albany). Mature adults of both sexes weighed about 1000 g and attained maturity at 830-900 g. Young were e

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Wood, Henry, Lauren Jamieson, Charles Manogaran, et al. "Correlation between the Integrated MDS Flow Cytometry Score and Genomic Abnormalities - a Single Centre Analysis from King's College Hospital." Blood 144, Supplement 1 (2024): 6751. https://doi.org/10.1182/blood-2024-211268.

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Myelodysplastic syndromes (MDS) are diagnosed based on peripheral cytopenias, morphological dysplasia and recurrent genomic abnormalities. Gene variants are found in approximately 90% of cases and cytogenetic abnormalities in 50% (Arber et al, 2022). Genomic abnormalities are key to diagnosis and prognosis (Bernard et al, 2022). The European Leukemia Net international MDS flow cytometry working group has recommended an integrated flow cytometry score (iFS) to support diagnosis of MDS (Oelshlaegel et al 2021; van de Loosdrecht et al, 2021). The score identifies three categories based on the num

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Maksymowych, W. P., I. Eshed, P. M. Machado, et al. "FRI0317 CONSENSUS DEFINITIONS FOR MRI LESIONS IN THE SPINE OF PATIENTS WITH AXIAL SPONDYLOARTHRITIS: FIRST ANALYSIS FROM THE ASSESSMENTS IN SPONDYLOARTHRITIS INTERNATIONAL SOCIETY CLASSIFICATION COHORT." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 749.2–750. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6304.

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Background:A recent consensus from the ASAS MRI group has culminated in updated spine lesion definitions for axial spondyloarthritis (ASAS_MRI_defn)1. There has been no central reader evaluation of MRI scans from the ASAS Classification Cohort (ASAS-CC)2to determine the spectrum of MRI lesions in the spine in this cohort.Objectives:To determine the spectrum of active and structural lesions on MRI images of the spine from the ASAS-CC according to the consensus ASAS_MRI_defnupdate.Methods:ASAS_MRI_defnwere recorded by 9 central readers in an eCRF for global assessment and detailed scoring of eac

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Sasaki, Koji, Nina Shah, Qaiser Bashir, et al. "Outcome of Patients with Light Chain Multiple Myeloma Compared to IgG/IgA Myeloma after Autologous Stem Cell Transplant." Blood 126, no. 23 (2015): 3194. http://dx.doi.org/10.1182/blood.v126.23.3194.3194.

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Abstract Introduction: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT) is the standard of care for younger patients with newly diagnosed multiple myeloma (MM). In approximately 15% of MM patients the monoclonal (M) spike consists of k or l light chains only as opposed to heavy + light chains. It remains unclear whether light chain (LC) MM has a different prognosis compared to other monoclonal protein subtypes after an auto-HCT. Methods: We retrospectively analyzed 1067 patients with MM who underwent auto-HCT between January 1, 2004 and January 1

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Cayetano, Margarette, Pocholo Autencio, and Walter Jerome Cabale. "Correlation of Resilience with Good Relations with Neighbors." Bedan Research Journal 5, no. 1 (2020): 109–29. http://dx.doi.org/10.58870/berj.v5i1.14.

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One of the internal resources being performed to have a better performance in different aspects of the individual life is resilience. The quality of resilience is frequently attributed to individuals who overcome all challenges and problems in life. The purpose of this study was to analyze the presence of correlation between resilience as a trait and neighborhood as an environmental factor. Wherein, neighborhood was further classified into five (5) underlying factors namely, the Physical Order, the Land Use and Service, the Social Norms and Values, the Social Capital, and, the Social order. Th

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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van Vollenhoven, R., T. Takeuchi, J. Aelion, et al. "POS0655 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 3-YEAR RESULTS FROM THE SELECT-EARLY STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 568–69. http://dx.doi.org/10.1136/annrheumdis-2021-eular.530.

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Background:Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) in MTX-naïve patients (pts) with rheumatoid arthritis (RA) through 48 weeks (wks).1Objectives:To report the efficacy and safety of UPA vs MTX mono up to 156 wks in pts with RA from the ongoing long-term extension (LTE) of the SELECT-EARLY trial.Methods:During the 48-wk double-blind study period, pts were randomized to UPA 15 or 30 mg once daily (QD) or MTX (titrated to 20 mg/wk by Wk 8). At Wk 26, pts who

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Issa, Ghayas C., Hagop M. Kantarjian, C. Cameron Yin, et al. "Prognostic Implications of Pre-Treatment Hypodiploidy and Complex Cytogenetics in Adult Patients with Acute Lymphocytic Leukemia (ALL) Treated with Hyper-CVAD." Blood 126, no. 23 (2015): 4874. http://dx.doi.org/10.1182/blood.v126.23.4874.4874.

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Abstract Background Pretreatment cytogenetic analysis is frequently used to predict response and outcome in hematologic malignancies. Hypodiploidy is associated with a poor prognosis in childhood ALL. Similarly, complex cytogenetics is a known adverse prognostic factor in myeloid malignancies. The impact of hypodiploidy and complex cytogenetics has not been extensively assessed in adult patients with ALL. To address this issue, we have conducted a retrospective analysis of all adult patients with ALL treated with frontline Hyper-CVAD based regimens at our institution. Methods We reviewed 332 a

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Amisha, Fnu, Ziad Abuhelwa, Wenyi Fan, et al. "Predictive Markers for Outcomes after Disease Progression Post BCMA-Directed CAR T-Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma." Blood 144, Supplement 1 (2024): 2004. https://doi.org/10.1182/blood-2024-211822.

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BACKGROUND Idecabtagene vicleucel (I) and Ciltacabtagene autoleucel (C) are two commercially available BCMA-directed CAR-T cell products initially FDA approved after &gt; 4 lines of therapy in patients with triple class exposed relapsed or refractory multiple myeloma patients (RRMM). Despite a high overall response rate, patients develop progressive disease. Little is known regarding factors associated with outcomes after progression post BCMA-directed CAR T-cell therapy and the optimal management strategy for post progression remains to be elusive. METHODS We conducted a single-center ret

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Orbai, A. M., L. C. Coates, A. Deodhar, et al. "POS1029 GUSELKUMAB-TREATED PATIENTS WITH PSORIATIC ARTHRITIS ACHIEVED CLINICALLY MEANINGFUL IMPROVEMENTS IN GENERAL HEALTH OUTCOMES MEASURED WITH PROMIS-29 THROUGH 52 WEEKS: RESULTS FROM THE PHASE 3 DISCOVER-1 TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 785–86. http://dx.doi.org/10.1136/annrheumdis-2021-eular.471.

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Background:In the DISCOVER-1 study, the interleukin-23 p19 subunit inhibitor guselkumab (GUS) demonstrated robust efficacy across joint and skin clinical manifestations of psoriatic arthritis (PsA).1 Patients (pts) with PsA also experience a broad range of symptoms that negatively impact health-related quality of life (eg, pain, fatigue, anxiety, depression, sleep disturbance, poor physical function).2Objectives:Assess the treatment effect of GUS on general health outcomes in pts with PsA in the DISCOVER-1 trial through Week (W) 52 using the Patient-Reported Outcomes Measurement Information Sy

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Belli, Carolina, Ronald Feitosa Pinheiro, Maria Gabriela Flores, et al. "Clinical Characteristics and Prognosis in South-American Patients with Myelodysplastic Syndrome: A Multicenter Study." Blood 124, no. 21 (2014): 4651. http://dx.doi.org/10.1182/blood.v124.21.4651.4651.

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Abstract There are previous reported data describing differences between European and Asian patients with Myelodysplastic Syndromes (MDS), and little is known about South-American (SA) patients. Our aim was to describe clinical characteristic of SA MDS population, to compare our series with diverse ethnicity, to evaluate scoring systems and prognostic factors. We retrospectively analysed a series of 1080 patients with de novo MDS (1981-2014) from Argentine (Ar-635), Brazil (Br-345), and Chile (Ch-100). Patients were classified following FAB and WHO criteria, excluding patients with bone marrow

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Hawksworth, D. L. "William Nylander's Collected Lichenological Papers. Edited and prefaced by Teuvo Ahti. 6 vols.: Lehre J Cramer [Vols IV-VI]; Berlin & Stuttgart: J. Cramer [Vols I–III]. - Vol. I: Introduction and Lichenological Papers 1852-1862. 1990, xlvi + Pp. 732, ISBN 3 44350013 7, DM 340. - Vol. II Lichenological Papers 1863-1868 with Addenda nova ad hchenographiam europaeam 1865-1867. 1990, Pp.850, ISBN 3 443 50014 5, DM340. - Vol. III Lichenological Papers 1869-1887. 1990, Pp. 559, ISBN 3 443 50015 3, DM 340. - Vol. IV Lichenological Papers 1888-1900. 1967, Pp. 821, ISBN 3 7682 0434 0, DM 150. - Vol. V Synopsis Methodica Lichenum 1,1:1858; I, 2: 1860; II: 1869, G. Lindau's Index Nominum Nylanderi Synopsis Lichenum 1907. 1967, Pp. 556, ISBN 3 7682 0435 9, DM 150. - Vol. VI: Prodromus Lichenographiae Galliae et Algeriae 1857, Lichenes Scandinaviae 1861, Lichenes Lapponiae Orientalis 1882. 1967, Pp. 636, ISBN 3 7682 0436 7, DM 150. Total price DM 1470." Lichenologist 26, no. 1 (1994): 97–98. http://dx.doi.org/10.1006/lich.1994.1009.

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Demirhan, Salih, Flor M. Munoz, Kristen G. Valencia Deray, et al. "Body Surface Area Valganciclovir Prophylactic Dosing is Associated with a Higher Rate of Drug-Associated Toxicities Compared to Body Weight Dosing in Pediatric Solid Organ Transplant Recipients." Journal of the Pediatric Infectious Diseases Society 12, Supplement_1 (2023): S23. http://dx.doi.org/10.1093/jpids/piad070.047.

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Abstract Background Valganciclovir (VGCV) is used for prevention of cytomegalovirus (CMV) in pediatric solid organ transplant (SOT) recipients who are at moderate or high risk for CMV infection or reactivation. Optimal dosing is not well defined, and both weight-based (WB) (15 mg/kg/dose) and body surface area-based (BSA) dosing (7 x BSA x creatinine clearance with an upper limit of 150 mL/min/1.73 m2) are used. We used a recently completed retrospective study on VGCV toxicity to compare the effects of these 2 dosing strategies on the proportion and the odds of CMV DNAemia, neutropenia, lympho

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Lyons, Roger M., Billie J. Marek, Carole Paley, et al. "Relationship Between Chelation and Clinical Outcomes in Lower-Risk Patients with Myelodysplastic Syndrome (MDS): Registry Analysis at 5 Years." Blood 124, no. 21 (2014): 1350. http://dx.doi.org/10.1182/blood.v124.21.1350.1350.

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Abstract Introduction: We prospectively collected data from lower-risk patients (pts) with MDS in an ongoing US registry in order to assess the association between chelation and clinical outcomes. In addition, we evaluated the association between chelation and overall survival (OS). Here we report outcomes at 5 years. Methods: The registry enrolled 600 pts from 107 US centers. Pts were ≥18 years old with lower-risk MDS (WHO, FAB, and/or IPSS criteria) and transfusional iron overload (serum ferritin ≥1000 µg/L and/or ≥20 packed red blood cell units and/or ≥6 units every 12 weeks). Pts were anal

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Yamamoto, Yuji, Wei-Chen Wen, Markus Andreas Schubert, Cedic Corley-Wiciak, and Bernd Tillack. "High Quality Ge Growth on Si (111) and Si (110) by Using Reduced Pressure Chemical Vapor Deposition." ECS Meeting Abstracts MA2022-02, no. 32 (2022): 1213. http://dx.doi.org/10.1149/ma2022-02321213mtgabs.

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Heteroepitaxial growth of Ge on Si has great interest for various optoelectronic applications such as Ge photodiodes(1). However 4.2% of lattice mismatch causes dislocation formation and island growth. High quality Ge(001) growth techniques are reported in ref.(2-4). Moreover, Ge(111) surface is also interesting because of higher carrier mobility(5). Furthermore, Ge(110) is preferred orientation of virtual substrates for epitaxial graphene growth(6). In the case of the Ge deposition on Si(111) and Si(110) substrates, it seems that the process conditions used for Ge growth on Si(001) are not su

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Browne, Iseult, Javier Pascual, Rosalind Cutts, et al. "Abstract PS06-04: The prognostic and predictive impact of circulating tumour DNA (ctDNA) dynamics in patients with metastatic Triple Negative Breast Cancer (TNBC) on olaparib based therapy: Results from Cohort E of the PlasmaMATCH trial." Cancer Research 84, no. 9_Supplement (2024): PS06–04—PS06–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps06-04.

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Abstract Background: Early changes in ctDNA levels, ctDNA dynamics, may help identify which patients are responding to therapy earlier than imaging. Few studies have assessed ctDNA dynamics during PARP inhibitor therapy. Here we report paired baseline and early on treatment ctDNA analysis from cohort E of plasmaMATCH, that recruited patients with TNBC to treatment with olaparib (PARP inhibitor) plus ceralasertib (ATR inhibitor). Methods: The plasmaMATCH trial assessed the ability of ctDNA testing to allocate patients to mutation matched treatment cohorts (A-D). Patients with TNBC, and without

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Rajadurai, Pathmanathan, Tatiana Semiglazova, Alinta Hegmane, et al. "Abstract P5-13-25: PIK3CA registry: A noninterventional, descriptive, retrospective cohort study of PIK3CA mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)." Cancer Research 82, no. 4_Supplement (2022): P5–13–25—P5–13–25. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-13-25.

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Abstract Introduction: PIK3CA mutations (mut) occur in ~40% of patients (pts) with HR+, HER2- ABC, and lead to phosphatidylinositol 3-kinase (PI3K) pathway hyperactivation, endocrine resistance, and poor survival in advanced disease. Alpelisib, an α-selective PI3K inhibitor and degrader, demonstrated efficacy in combination with fulvestrant in the Phase III SOLAR-1 trial in pts with PIK3CA-mut HR+, HER2- ABC. Notably, treatment benefit was not seen in pts without PIK3CA-mut tumors. Expert guidelines now recommend testing for PIK3CA mut at advanced diagnosis; however, data on PIK3CA mut prevale

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Кузнецов, Сергей Викторович, Алексей Сергеевич Низамутдинов, Эдуард Ильдарович Мадиров та ін. "Исследование люминесценции твердых растворов на основе фторида иттрия, легированных иттербием и европием для фотоники". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 2 (2020): 225–31. http://dx.doi.org/10.17308/kcmf.2020.22/2834.

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Подавляющая часть мирового рынка солнечных фотоэлектрических устройств основывается на кремниевых технологиях. Актуальной задачей является повышение эффективности их работы за счет использования люминесцентных покрытий, в том числе преобразующих излучение из УФ-синей области спектра в ближний инфракрасный диапазон, где кремний поглощает излучение с наибольшей эффективностью (стоксовая, или даун-конверсионная люминесценция) или из инфракрасной области спектра в ближний инфракрасный диапазон (ап-конверсионная люминесценция). Целью данного исследования были синтез и исследование спектрально-кинет

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Wesseling, Jelle. "Abstract F1-2: Clonal evolution of DCIS to invasion." Cancer Research 83, no. 5_Supplement (2023): F1–2—F1–2. http://dx.doi.org/10.1158/1538-7445.sabcs22-f1-2.

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Abstract Clonal evolution of DCIS to invasion Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive breast cancer (IBC). If not treated, at least 3 out of 4 women with DCIS will not develop IBC1-3. This implies many women with non-progressive, low-risk DCIS are likely to carry the burden of overtreatment. To solve this DCIS dilemma, two fundamental questions need to be answered. The first question is, how the subsequent IBC is related to the initial DCIS lesion. The seco

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Kuppuraju, R., P. May, T. Millliken, S. Kitancho, and D. Bulbin. "POS0518 TREATMENT OF GOUT AND ITS EFFECTS ON METABOLIC SYNDROME." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 521.3–522. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3206.

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BackgroundThere is a known relationship between elevated serum urate (SUA) levels and renal, cardiovascular (CV), and metabolic disease. However, the precise reasons for this remain poorly defined.The CANTOS trial found a significant decrease in nonfatal MI, stroke, or CV death in patients (PTs) treated with canakinumab vs placebo. The LoDoCo2 trial found a decrease in CV death, nonprocedural MI, ischemic stroke, and ischemia-driven need for coronary revascularization in PTs treated with colchicine vs placebo. This suggests that inflammation is an independent risk factor for CV disease. The GO

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Mohamed, Fawzy, El Naggar Ayman, Kazamel Gada, and Fawzy Mohamed. "Comparative study between thrombolytic therapy and surgery in 30 cases of acute left sided prosthetic valve thrombosis." Biolife 5, no. 3 (2022): 361–69. https://doi.org/10.5281/zenodo.7371013.

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<strong>ABSTRACT</strong> <strong>Introduction:</strong> Prosthetic valve thrombosis is a potentially life-threatening complication associated with high morbidity and mortality. Transthorasic and transoesophageal echocardiography play an important role to the diagnosis and provides incremental information about the optimal treatment strategy. Guidelines differ on whether surgical treatment or fibrinolysis should be the treatment of choice for the management of left-sided prosthetic valve thrombosis. The aim of the study is to compare between thrombolytic therapy and surgery regarding success,

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Khaled, Yasser, Sung Choi, David A. Hanauer, and Pavan Reddy. "Nephrotic Syndrome After Allogeneic Hematopoietic Cell Transplantation: Incidence and Outcomes." Blood 114, no. 22 (2009): 3324. http://dx.doi.org/10.1182/blood.v114.22.3324.3324.

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Abstract Abstract 3324 Poster Board III-212 The NIH Consensus recognizes nephrotic syndrome (NS) as part of the chronic GVHD symptomatology, but this manifestation is rare and the incidence and outcomes have not been well-defined. To characterize this complication, we conducted an IRB-approved retrospective review of 626 consecutive patients (age > 16 yrs: related donor [RD], n=352; unrelated donor [URD], n=274) who underwent allogeneic hematopoietic cell transplantation (HCT) between October 2000 and December 2007 at the University of Michigan. Data abstraction was facilitated by the use o

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Sood, Suman L., Dunlei Cheng, Margaret V. Ragni, et al. "A Cross-Sectional Analysis of Cardiovascular Disease in the Hemophilia Population." Blood 126, no. 23 (2015): 761. http://dx.doi.org/10.1182/blood.v126.23.761.761.

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Introduction: Cardiovascular disease (CVD) is a disease of aging. While men with hemophilia were initially thought to be protected from CVD, it is now clear that atherothrombotic events do occur. The objective of this study is to determine the prevalence of CVD and CV risk factors in older men with moderate and severe hemophilia. Methods: A U.S. national cross-sectional study began enrollment in 10/2012. Included are men with moderate or severe congenital hemophilia A or B (FVIII or IX level ≤ 5%), age 54-73. Men with an additional bleeding disorder (besides liver dysfunction) were excluded. A

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Imad Abdelhamid EL HACI, Wissame MAZARI, and Fawzia ATIK-BEKKARA. "Effect of Ammodaucus leucotrichus Coss. & Dur. Essential Oil on the Viability of Erythrocytes and its Antiradical Activity Assessment." Journal of Natural Product Research and Applications 1, no. 02 (2021): 45–53. http://dx.doi.org/10.46325/jnpra.v1i02.14.

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Plants for medicinal purposes are considered as the main source of health care for the majority of the world population. In order to promote medicinal plants in Algeria, the present work aimed to assess the physico-chemical characterization, hemolytic, and antioxidant activities of Ammodaucus leucotrichus essential oil of an endemic plant from south-west of Algeria. The plant was harvested from the region of Bechar (south-west of Algeria). The oil was obtained by hydrodistillation method using Clevenger apparatus. The antioxidant activity of the oil was carried out using DPPH scavenging assay,

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Aringer, M., L. Arnaud, C. Peschken, et al. "POS0731 ASSOCIATION OF PATIENT-REPORTED OUTCOMES WITH TYPE I INTERFERON GENE SIGNATURE FROM THE INTERNATIONAL SYSTEMIC LUPUS ERYTHEMATOSUS PROSPECTIVE OBSERVATIONAL COHORT STUDY (SPOCS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 648–49. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1181.

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BackgroundThe aim of the Systemic Lupus Erythematosus Prospective Observational Cohort Study (SPOCS) is to examine the disease course of patients with systemic lupus erythematosus (SLE) in relation to their type I interferon gene signature (IFNGS) status.1 IFNGS has been associated with SLE disease activity.2ObjectivesTo identify associations between IFNGS status and patient-reported outcomes (PROs) among patients receiving clinical care while enrolled in SPOCS.MethodsThis noninterventional, international, prospective, observational cohort study included adult patients (≥18 years) with moderat

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Sood, Suman L., Dunlei Cheng, Amy D. Shapiro, et al. "A Cross-Sectional Analysis of Cardiovascular Disease in the Hemophilia Population." Blood 124, no. 21 (2014): 2836. http://dx.doi.org/10.1182/blood.v124.21.2836.2836.

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Abstract Introduction: Cardiovascular disease (CVD) is a disease of aging. While men with hemophilia were initially thought to be protected from CVD, it is now clear that atherothrombotic events do occur. The objective of this study is to determine the prevalence of CVD and CV risk factors among older men with moderate and severe hemophilia. Methods: A U.S. national cross-sectional study began enrollment in 10/2012. Inclusion criteria are men with moderate or severe congenital hemophilia A or B (FVIII or IX level ≤ 5%), age 54-73. Men with an additional bleeding disorder (besides liver dysfunc

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Aletaha, D., R. Westhovens, T. Atsumi, et al. "POS0678 CLINICAL OUTCOMES OF METHOTREXATE (MTX)-NAIVE RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) ON FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL INITIALLY ON FIL OR MTX DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 614–15. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1638.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesIn this post hoc, exploratory analysis, efficacy and safety of long-term treatment with FIL (± MTX) were assessed in MTX-naïve pts treated with FIL or MTX in the Phase 3 PS (NCT02886728).1MethodsPts received FIL 200 mg (FIL200)+MTX, FIL 100 mg (FIL100)+MTX, FIL200 alone, or MTX alone up to 52 W in PS.1 Those completing PS on study drug could enter LTE (NCT03025308; data cutoff: June 1, 2020). MTX completers were rerandomized, blinded, to FIL200 or FIL1

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