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Journal articles on the topic '347.824.2 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Stilgenbauer, Stephan, Barbara F. Eichhorst, Raymonde Busch, et al. "Biologic and Clinical Markers for Outcome after Fludarabine (F) or F Plus Cyclophosphamide (FC) - Comprehensive Analysis of the CLL4 Trial of the GCLLSG." Blood 112, no. 11 (2008): 2089. http://dx.doi.org/10.1182/blood.v112.11.2089.2089.

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Abstract The CLL4 trial evaluated 1st line treatment with F or FC among 375 CLL patients up to 65 years (Eichhorst et al., Blood, 2006). Updated follow-up (median 52.8 months (mo) for alive patients) revealed 50.4% events for progression-free survival (PFS) and 24.5% for overall survival (OS). Comparing the treatment arms, significant differences were observed in favor of FC for CR (19.9% vs 5.9%, p&lt;.001), CR+PR (94.7% vs 82.4%, p&lt;.001), and PFS (median 67.8 vs 43.7 mo, p=.002) but not for OS (median n.r. vs 84.6 mo, p=.191). The incidences of genomic aberrations by FISH (n=321)

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Ngazizah, Yetti Nur, Rismayeti Rismayeti, and Hadira Latiar. "ANALISIS SISTEM PENATAAN DAN TEMU BALIK ARSIP INAKTIF DI DINAS PANGAN, TANAMAN PANGAN DAN HORTIKULTURA PROVINSI RIAU." Jurnal Pustaka Budaya 8, no. 2 (2021): 119–25. http://dx.doi.org/10.31849/pb.v8i2.6113.

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This study aims to determine how the system of structuring and retrieval of inactive archives in the Department of Food, Crops and Horticulture Riau Province. The method used in this study is descriptive data analysis method. The data analysis techniques carried out by researchers are data reduction, data presentation and conclusion drawing. Meanwhile, archive retrieval refers to the calculation of recall-precision. The research population is all staff of the General and Civil Service Sub-Division who opened 25 people and inactive archives in 2015 which opened 327 archives. The research sample

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Reyes, E. A., D. R. Bergfelt, V. F. Ratto, X. P. Valderrama, E. Arcelay, and M. H. Ratto. "122 OVARIAN FOLLICULAR DYNAMICS IN CROSS-BRED EWES DURING THE RAINY SEASON UNDER TROPICAL CONDITIONS." Reproduction, Fertility and Development 29, no. 1 (2017): 169. http://dx.doi.org/10.1071/rdv29n1ab122.

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Small ruminants are an important livestock species on many island nations of the Eastern Caribbean region and serve as a vital source of food and income. This study was designed to characterise follicular development during the inter-ovulatory interval (interval between 2 consecutive ovulations) under tropical conditions. Non-lactating, 2- to 4-year-old crossbred Barbados-Black Belly × White Virgin Island ewes weighing a mean 30.4 kg with mean body condition score 2.9 (score 1–5) were used during September–November for the study. Ewes were maintained in a paddock of 100 m2 at the research farm

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Ohashi, Takuya, Mitsumasa Kawago, Yoshimitsu Hirai, et al. "Efficacy of Continuous Saline Irrigation Therapy for Descending Necrotizing Mediastinitis." Surgery Journal 09, no. 03 (2023): e107-e111. http://dx.doi.org/10.1055/s-0043-1775559.

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Abstract Objectives Descending necrotizing mediastinitis (DNM) is a poor prognosis disease. This study aims to examine the patient background and treatment of DNM and to identify more effective treatments for DNM. Methods The patient background and treatment of 11 patients who underwent surgery for DNM between November 2010 and June 2021 were studied. The patients were divided into six patients who underwent continuous saline irrigation (group I) and five patients who did not (group N). The differences in the drainage duration and length of hospital stay between the two groups were retrospecti

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Deodhar, A., M. Nowak, J. Ye, et al. "AB0891 Deucravacitinib Efficacy in Psoriatic Arthritis by Baseline DMARD Use: Exploratory Analysis From a Phase 2 Study." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1571–72. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1391.

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BackgroundPsoriatic arthritis (PsA) treatment guidelines recommend that patients (pts) inadequately responding to conventional synthetic DMARDs (csDMARDs) can be treated with targeted synthetic DMARDs with or without background use of csDMARDs. Deucravacitinib (DEUC) is a novel, oral, selective, allosteric inhibitor of tyrosine kinase 2 (TYK2) that binds to the unique TYK2 regulatory domain, thereby suppressing signaling of key cytokines (eg, IL-23) involved in PsA pathogenesis. In a Phase 2 trial in pts with active PsA, DEUC was well tolerated and significantly more efficacious than placebo (

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Miller, Kevin C. "Plasma Potassium Concentration and Content Changes After Banana Ingestion in Exercised Men." Journal of Athletic Training 47, no. 6 (2012): 648–54. http://dx.doi.org/10.4085/1062-6050-47.6.05.

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Context Individuals prone to exercise-associated muscle cramps (EAMCs) are instructed to eat bananas because of their high potassium (K+) concentration and carbohydrate content and the perception that K+ imbalances and fatigue contribute to the genesis of EAMCs. No data exist about the effect of bananas on plasma K+ concentration ([K+]p) or plasma glucose concentration ([glucose]p) after exercise in the heat. Objective To determine whether ingesting 0, 1, or 2 servings of bananas after 60 minutes of moderate to vigorous exercise in the heat alters [K+]p or [glucose]p and whether changes in [K+

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Claviez, Alexander, Markus Tiemann, Heike Lueders, Reza Parwaresch, Guenther Schellong, and Wolfgang Doerffel. "The Impact of Latent Epstein-Barr Virus Infection on Outcome in Children and Adolescents with Hodgkin’s Lymphoma." Blood 104, no. 11 (2004): 3121. http://dx.doi.org/10.1182/blood.v104.11.3121.3121.

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Abstract The prognostic significance of latent Epstein-Barr virus (EBV) infection in Hodgkin’s lymphoma (HL) is debated controversially. Especially in the pediatric age group, no conclusive data are available due to small series. 842 children and adolescents (55% male) with a median age of 13.7 years (range, 2–20) from consecutive pediatric DAL/GPOH multicenter treatment studies HD-90 and HD-95 were studied for the presence of latent EBV infection in Hodgkin and Reed-Sternberg cells by immunostaining against latent membrane protein 1 (LMP-1). Histology subtypes were as follows: nodular scleros

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Darvin, V. V., P. S. Vetshev, S. V. Onishchenko, M. M. Lysak, T. S. Vardanyan, and A. L. Kostrubin. "Obstructive jaundice: epidemiology, diagnosis and choice of optimal method of biliary decompression." Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery 28, no. 4 (2023): 16–23. http://dx.doi.org/10.16931//1995-5464.2023-4-16-23.

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Aim. To analyze epidemiological features and morbidity structure in obstructive jaundice, to estimate the results of diagnosis and treatment of this category of patients and to evaluate factors affecting the effectiveness of the treatment and diagnostic program.Materials and methods. The study was based on four-year experience of treatment of 484 patients with mechanical jaundice. Ultrasound, CT, MRI, endoscopic ultrasound, and cholangioscopy were used to diagnose the level of the obstruction and the causes of obstructive jaundice. The main method of decompression involved transpapillary inter

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Schäfer, Stefan B., Claudia Rudolph, Martin Kolodziej, Frank Mauermann, Fritz Christian Roller, and Gabriele Anja Krombach. "Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 191, no. 11 (2019): 1015–25. http://dx.doi.org/10.1055/a-0881-3113.

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Purpose Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps. Materials and Methods In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. A visual assessment of the image quality was performed by two radiologists on the basi

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Kantathut, Narongrit, Piya Cherntanomwong, Siam Khajarern, and Parinya Leelayana. "Lactated Ringer’s as a Base Solution for del Nido Cardioplegia." Journal of ExtraCorporeal Technology 51, no. 3 (2019): 153–59. http://dx.doi.org/10.1051/ject/201951153.

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Unavailability of Plasma-Lyte A precludes the utility of traditional del Nido cardioplegia in many countries. This observational study aimed to evaluate myocardial preservation and clinical outcomes when using lactated Ringer’s solution as the base solution for del Nido cardioplegia as compared with our institute’s standard blood cardioplegia strategy. Eighty-nine adult patients underwent cardiac surgery for acquired heart disease from February 2017 to November 2017 either with del Nido cardioplegia (n = 44) or blood cardioplegia (n = 45). Clinical data and outcomes were compared. Patient char

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PRADHAN, ABANI K., YANBIN LI, JOHN A. MARCY, MICHAEL G. JOHNSON, and MARK L. TAMPLIN. "Pathogen Kinetics and Heat and Mass Transfer–Based Predictive Model for Listeria innocua in Irregular-Shaped Poultry Products during Thermal Processing." Journal of Food Protection 70, no. 3 (2007): 607–15. http://dx.doi.org/10.4315/0362-028x-70.3.607.

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The increasing demand of ready-to-eat poultry products has led to serious concerns over product safety, and more emphasis has been placed on thorough cooking of products. In this study, processing conditions and thermal inactivation of Listeria innocua in chicken breast meats were evaluated during convection cooking in a pilot-plant scale air-steam impingement oven. A predictive model was developed by integrating heat and mass transfer models with a pathogen kinetics model to predict temperature, water content, product yield, and bacterial inactivation during air-steam impingement cooking. Ski

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Collantes, Yesusa, and Oscar Perales-Perez. "Structural and Functional Properties of Iron (II, III)-Doped ZnO Monodisperse Nanoparticles Synthesized by Polyol Method." MRS Proceedings 1547 (2013): 129–34. http://dx.doi.org/10.1557/opl.2013.1028.

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ABSTRACTIn this work, bare and (Fe3+ and Fe2+)-doped ZnO nanoparticles (NPs) have been synthesized in a polyol medium at 180oC. The synthesis in polyol allows a precise control of doping under size-controlled conditions. The Fe concentration varied in the 0-2 at. % range. As-synthesized samples were characterized by X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), Photoluminescence (PL) spectroscopy and Vibrational Sample Magnetometry (VSM). XRD measurements confirmed the formation of well crystallized wurtzite ZnO with absence of secondary phases in bare and doped samples; the ave

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Mahdi, Muna Iskandar, and Kassim Hassan Kadhim. "A batch and cloud point extraction kinetic spectrophotometric method for determining trace and ultra trace amounts of Benzodiazepine drugs (Clonazepam and Nitrazepam) in pure and pharmaceutical preparations." Current Issues in Pharmacy and Medical Sciences 33, no. 1 (2020): 21–31. http://dx.doi.org/10.2478/cipms-2020-0006.

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AbstractUtilizing the batch Diazotization coupling reaction and the cloud point extraction kinetic spectrophotometric method, trace and Ultra trace amounts from reducing Nitrazepam and Clonazepam were evaluated by way of using 2,5-dimethoxyaniline as a new Chromogenic reagent to give colored products (red) in acidic medium which have a maximum absorption at 500 and 502 nm, respectively. In the work, the analytical data of batch and cloud point for Nitrazepam and Clonazepam depended on initial rate and fixation time. This involved concentrations of (0,3-9), (0.05-1.2), (0.5-10) and (0.025-1) µg

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Lee, L. Y., E. R. Beck, R. F. Morton, Y. R. Kou, and D. T. Frazier. "Role of bronchopulmonary C-fiber afferents in the apneic response to cigarette smoke." Journal of Applied Physiology 63, no. 4 (1987): 1366–73. http://dx.doi.org/10.1152/jappl.1987.63.4.1366.

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The role of vagal bronchopulmonary C-fiber afferents in eliciting the immediate changes in breathing pattern after acute inhalation of cigarette smoke was assessed with a selective blockade of myelinated vagal afferents (innervating both stretch and irritant receptors) utilizing the method of differential cooling. In 15 of 17 chloralose-anesthetized dogs tested, spontaneous inhalation of cigarette smoke (19.7% avg conc, 500–700 ml vol) reproducibly caused the following immediate responses: apnea, bradycardia, and hypotension. These responses occurred within 1 to 2 breaths of smoke inhalation a

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Cabrera, Roberto M., M. E. Saltveit, and K. Owens. "SENSITIVITY OF CUCUMBER LINES TO CHILLING INJURY." HortScience 25, no. 9 (1990): 1174b—1174. http://dx.doi.org/10.21273/hortsci.25.9.1174b.

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Cucumber fruit (Cucumis sativus L.) of 13 cultivars were chilled at 2.5C for up to 10 d, Pitting scores after 8 d at 2.5C and 6 d at 20C ranged from 0.0 (none) in `HP 138' to 7.7 (severe) in `Poinsett 76' fruit. Ion leakage, as the increase in conductivity in a 0.3 M mannitol solution bathing excised disks of mesocarp tissue and expressed as % of the total ion content of the tissue, was lowest in `MDR I' (4.5%) and highest in `HP 159' (11%) after 6 d at 2.5C. After 10 d at 2.5C, however, the lowest was in `Navajo' (5.5%) and the highest in `Poinsett 76' (15%). Resistant lines, e.g., `Dasher II

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Tamba, Rony, Magdalena Sidhartani, and Musrichan Musrichan. "Faktor Risiko Infeksi Respiratorik Akut Bawah pada Anak." Sari Pediatri 11, no. 5 (2016): 330. http://dx.doi.org/10.14238/sp11.5.2010.330-4.

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Latar belakang. Infeksi respiratorik akut (IRA) bawah merupakan penyebab terpenting morbiditas danmortalitas pada anak. Beberapa faktor risiko yang berpengaruh tehadap IRA bawah pada anak, antara lainstatus ekonomi rendah, berat badan lahir rendah, ASI tidak eksklusif, malnutrisi, hunian padat, dan polusiudara.Tujuan. Menentukan faktor risiko yang berpengaruh terhadap terjadinya IRA bawah pada anak yang dirawatdi bangsal Anak RSUP dr Kariadi.Metode. Penelitian dengan rancangan kasus kontrol. Subjek penelitian adalah 78 pasien IRA bawah usia1 bulan sampai 14 tahun yang dirawat di bangsal bagian

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Guilemany, Jose Maria, Isam Alobid, Centellas Silvia, Manuel S. Bernal-Sprekelsen, and Joaquim Mullol I. Miret. "S290 – Sinonasal Pathology and Severity of Bronchiectasis." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P171—P172. http://dx.doi.org/10.1016/j.otohns.2008.05.466.

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Objectives 1) To investigate the prevalence of nasal symptoms, nasal polyposis, and sinusal opacification in patients with bronchiectasis. 2) To investigate the association between the degree of sinusal opacification and the bronchiectasis extension. Methods 88 consecutive patients with stable non-cystic bronchiectasis were prospectively evaluated for nasal symptoms (RASP, 0–3), polyp size (nasal endoscopy, 0–3), sinusal occupation (CT, 0–24), and chest HRCT (0–18). Results Following EP3OS criteria, 77% of patients presented had chronic rhinosinusitis (CRS). Nasal congestion (incidence: 90%; s

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Gandi, Carlo, Angelo Totaro, Riccardo Bientinesi, et al. "Purely Off-Clamp Partial Nephrectomy: Robotic Approach Better than Open Using a Pentafecta Outcome with Propensity Score Matching." Journal of Clinical Medicine 11, no. 21 (2022): 6241. http://dx.doi.org/10.3390/jcm11216241.

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Partial nephrectomy (PN) is the gold standard treatment for localized renal masses. Robot-assisted PN (RAPN) has overcome laparoscopy’s technical limitations, greatly expanding the indications of minimally invasive PN, which is dominated by renal artery clamping in almost all published series. We compared off-clamp RAPN (OFFC-RAPN) with the open approach (OFFC-OPN) using propensity score (PS) matching. A favourable pentafecta outcome was defined as a combination of no positive surgical margins (PSM), no complications of Clavien–Dindo (CD) grade ≥ 3, post-operative eGFR loss <10%, length of

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Tomizawa, Daisuke, Akio Tawa, Tomoyuki Watanabe, et al. "Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)." Blood 120, no. 21 (2012): 2615. http://dx.doi.org/10.1182/blood.v120.21.2615.2615.

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Abstract Abstract 2615 Background: Infants (age <1 year) with AML are naturally vulnerable to intensive cytotoxic therapy, and we have previously reported unacceptably high early death rate mainly due to pulmonary complications among the first 32 infants (28 eligible) enrolled in the JPLSG AML-05 study, which prompted us to suspension of patient accrual and protocol amendment (Tomizawa D. 52ndASH abstract #2146). Seventeen additional infants were enrolled after the amendment, and here we report the final outcome of total 45 infants with AML treated on AML-05 study. Patients & Methods: J

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Freyer, G., M. Debled, J. F. Geay, et al. "Celecoxib (Ce) + exemestane (Ex) versus placebo + Ex in post-menopausal (PM) metastatic breast cancer (MBC) patients (pts): A double-blind phase III GINECO study." Journal of Clinical Oncology 24, no. 18_suppl (2006): 565. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.565.

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565 Background: in vitro and in vivo studies suggest that COX-2 inhibitors have proper antitumor effect and could enhance the activity of aromatase inhibitors (AI). Methods: PM first-line MBC pts without previous adjuvant AI were randomized to receive per os until progression either A: Ce (400 mg bid) + Ex (25mg/d) or B: placebo (1 tablet bid) + Ex (25mg/d). PFS was the main end-point. The trial was prematurely stopped (Dec 2004) with 157/342 pts enrolled (A: 74, B: 83 pts) after occurrence of Ce cardio-vascular toxicity in other trials. Results: patient (median age, A:61, B:63 yrs) characteri

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Pervin, Mst Shahnaj, Hasan Shahriar Md Nuruzzaman, Eliza Sultana, and Anis Uddin Ahmad. "Comparison of Onlay versus Sublay Mesh Repair in Ventral Hernia : Our Experience in a Peripheral Hospital." Journal of Surgical Sciences 24, no. 2 (2021): 61–65. http://dx.doi.org/10.3329/jss.v24i2.52316.

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Background: Mesh repair is the standard procedure of choice for the ventral hernia repair. The common techniques for this surgery are onlay and sublay repair. But the superior technique between the two is yet to be established objectives. Objectives: We conducted this study to compare the results of Onlay with Sublay mesh repair for the treatment of ventral hernia. Methods: This comparative study was conducted at the department of Surgery, Shaheed Tajuddin Ahmad Medical College Hospital, Gazipur from April 2018 to April 2019. 20 patients withclinically diagnosed ventral hernia were

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Biddeci, Giada, Elena Varotto, Maria Paola Boaro, et al. "Features of Avascular Osteonecrosis in Children Treated for Acute Lymphoblastic Leukaemia: Experience in a Single Center." Blood 128, no. 22 (2016): 5158. http://dx.doi.org/10.1182/blood.v128.22.5158.5158.

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Abstract Because survival of pediatric acute lymphoblastic leukaemia (ALL) has improved in the last years, adverse effects acquire increasing importance. Avascular osteonecrosis (ON) is a long term complication of ALL treatment affecting the patients' quality of life. Its pathogenesis recognizes multiple factors (age, race, genetics, chemotherapies and steroids). The different roles of dexamethasone (DXM) versus prednisone (PDN) is still under discussion, as dosages and rate of administration. The prevalence of ON varies in different series (0.43-17.6%). It affects mostly the weight-bearing ep

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Austin, Publishing Group. "The Role of Calcium in Augmenting the Efficacy of Primary Homeostasis after Hemorrhagic Shock." Annals of Hematology & Oncology 10, no. 1 (2023): 1415. https://doi.org/10.26420/annhematoloncol.2023.1415.

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Abstract <strong>Background:</strong> Traumatic Hemorrhagic Shock (THS) causes hypocalcemia (Ca). This study assesses how low Ca affects platelet (Plt) function. <strong>Study Design:</strong> A research registry was queried for 555 studies on 341 patients (pts) with THS requiring 14.2 units RBC, 8.4 units FFP, 3.6 units Plt, and 18.9 mEq Ca by end of O.R. (7.3 hours). Factors analyzed included Plt count, Ca, Bleeding Time (BT), Plt aggregation with ADP (PAadp) and collagen (PAcol), including Max PA, T1/2 PA, and rate PA, plus platelet release factors, beta thromboglobulin (BTG) and

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Galanello, Renzo, and Raffaella Origa. "Neutropenia in Patients with Thalassemia Major." Blood 104, no. 11 (2004): 3763. http://dx.doi.org/10.1182/blood.v104.11.3763.3763.

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Abstract Monitoring of the neutrophil count has become an important issue in the management of thalassemia patients after the introduction of the new oral chelator deferiprone, as this chelator has been associated with agranulocytosis and milder neutropenias. Although a clear relation between deferiprone and agranulocytosis has been demonstrated, it is unclear whether milder neutropenias are due to deferiprone use or to other factors such as hypersplenism, infections, autoantibodies, or other drugs. In this study we evaluated 7,708 consecutively blood counts and leukocyte differential obtained

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Mustafaev, A. R. "The epizootic situation of bovine leukemia in the Republic of Dagestan in 2023." International Journal of Veterinary Medicine, no. 2 (June 28, 2024): 17–23. http://dx.doi.org/10.52419/issn2072-2419.2024.2.17.

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Bovine enzootic leukemia (EBLV) remains an acute problem for animal husbandry in many regions of Russia. Based on this, the goal was set: to study the epizootic situation of bovine leukemia in the Republic of Dagestan. The material for the study was taken from the official source of the Veterinary Committee of the Republic, as well as supplemented with our own serological blood tests for bovine leukemia virus (bovine leukemia). Laboratory tests for the detection of antibodies to BLV in RID were carried out according to the "Guidelines for the diagnosis of bovine leukemia" (2000). Research resu

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Ruther, Nancy R., Alcee Jumonville, Michelle A. Mathiason, Ann E. Emmel, Sandra K. Wee, and Ronald S. Go. "Speed of accrual into published phase III oncology trials: A comparison across geographic locations." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6074. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6074.

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6074 Background: There is a perception that patient accrual may be slower in the US than it is in Europe (Wang-Gillam A et al, J Clin Oncol 2010;28:3803-3807). However, a systematic study has not been performed. We seek to determine the speed at which patients are accrued into published phase III oncology trials across geographic locations and to identify factors that may influence this process. Methods: We searched MEDLINE and identified all original phase III oncology therapeutic trials published in 2006-2010 (N = 567). Trials with no reported activation and completion dates were excluded (n

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Gude, Martin Faurholdt, Jan Brink Valentin, Milena Meisner-Jensen, et al. "Video Streaming or Telephone Communication During Emergency Medical Services Dispatch Calls." JAMA Network Open 8, no. 7 (2025): e2519020. https://doi.org/10.1001/jamanetworkopen.2025.19020.

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ImportanceVideo streaming during emergency medical calls may enhance triage precision and optimize health resource allocation. However, its clinical safety and effect on key outcomes remain unexplored in randomized clinical trials.ObjectiveTo assess whether video streaming during emergency calls reduces highest-urgency ambulance dispatches while ensuring safety through outcomes such as 24-hour hospital admissions among initially nonconveyed patients, mortality, and intensive care unit (ICU) admissions.Design, Setting, and ParticipantsThis cluster randomized clinical trial was conducted across

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Galdeano Lozano, Marina, Julio César Alfaro Álvarez, Núria Parra Macías, et al. "Effectiveness of Intermediate Respiratory Care Units as an Alternative to Intensive Care Units during the COVID-19 Pandemic in Catalonia." International Journal of Environmental Research and Public Health 19, no. 10 (2022): 6034. http://dx.doi.org/10.3390/ijerph19106034.

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Objectives: During the COVID-19 pandemic, the risk of collapse for the health system created great difficulties. We will demonstrate that intermediate respiratory care units (IRCU) provide adequate management of patients with non-invasive respiratory support, which is particularly important for patients with SARS-CoV-2 pneumonia. Methods: A prospective observational study of patients with COVID-19 admitted to the ICU of a tertiary hospital. Sociodemographic data, comorbidities, pharmacological, respiratory support, laboratory and blood gas variables were collected. The overall cost of the unit

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Rumalla, Kavelin, Chester K. Yarbrough, Andrew J. Pugely, and Ian G. Dorward. "Spinal Fusion for Pediatric Spondylolisthesis: National Trends, Complications, and Short-Term Outcomes." Neurosurgery 82, no. 5 (2017): 701–9. http://dx.doi.org/10.1093/neuros/nyx295.

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AbstractBACKGROUNDCurrent surgical management guidelines for pediatric spondylolisthesis (PS) are reliant on data from single-center cohorts.OBJECTIVETo analyze national trends and predictors of short-term outcomes in spinal fusion surgery for PS by performing a retrospective cross-sectional analysis of the Kids’ Inpatient Database (KID).METHODSThe KID (sampled every 3 yr) was queried from 2003 to 2012 to identify all cases (age 5-17) of spinal fusion for PS (n = 2646). We analyzed trends in patient characteristics, surgical management, and short-term outcomes. Both univariate and multivariabl

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Lachman, J., E. C. Fernández, and M. Orsák. "Yacon [Smallanthus sonchifolia (Poepp. et Endl.) H. Robinson] chemical composition and use – a review." Plant, Soil and Environment 49, No. 6 (2011): 283–90. http://dx.doi.org/10.17221/4126-pse.

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Yacon [Smallanthus sonchifolia (Poepp. et Endl.) H. Robinson], a&nbsp;native plant of the Andes, belongs to the family Compositae (Asteraceae) and it represents a&nbsp;traditional crop of the original population of Peru used in traditional medicine. A&nbsp;major portion of tuberous root biomass is composed of water (&gt; 70% of fresh weight). Saccharides, especially oligo-fructans, form 70&ndash;80% of dry weight, protein content ranges between 0.3% and 3.7%. Fructooligosaccharides of inulin type b (2&reg;1), mainly oligomers (GF2&ndash;GF16), are known for their ab

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Irastorza, Ramiro M., Timothy Maher, Michael Barkagan, et al. "Limitations of Baseline Impedance, Impedance Drop and Current for Radiofrequency Catheter Ablation Monitoring: Insights from In Silico Modeling." Journal of Cardiovascular Development and Disease 9, no. 10 (2022): 336. http://dx.doi.org/10.3390/jcdd9100336.

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Background: Baseline impedance, radiofrequency current, and impedance drop during radiofrequency catheter ablation are thought to predict effective lesion formation. However, quantifying the contributions of local versus remote impedances provides insights into the limitations of indices using those parameters. Methods: An in silico model of left atrial radiofrequency catheter ablation was used based on human thoracic measurements and solved for (1) initial impedance (Z), (2) percentage of radiofrequency power delivered to the myocardium and blood (3) total radiofrequency current, (4) impedanc

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Weber, Michelle L., John-Henry L. Dean, Nicole L. Hoffman, et al. "Influences of Mental Illness, Current Psychological State, and Concussion History on Baseline Concussion Assessment Performance." American Journal of Sports Medicine 46, no. 7 (2018): 1742–51. http://dx.doi.org/10.1177/0363546518765145.

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Background: A student-athlete’s mental state, including history of trait anxiety and depression, or current psychological state may affect baseline concussion assessment performance. Purpose: (1) To determine if mental illness (anxiety, depression, anxiety with depression) influences baseline scores, (2) to determine if psychological state correlates with baseline performance, and (3) to determine if history of concussion affects Brief Symptom Inventory–18 (BSI-18) subscores of state anxiety, depression, and somatization. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A sa

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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Barwood, Martin J., Joe Kupusarevic, and Stuart Goodall. "Enhancement of Exercise Capacity in the Heat With Repeated Menthol-Spray Application." International Journal of Sports Physiology and Performance 14, no. 5 (2019): 644–49. http://dx.doi.org/10.1123/ijspp.2018-0561.

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Purpose: Exercise performance is impaired in the heat, and a contributing factor to this decrement is thermal discomfort. Menthol spraying of skin is one means of alleviating thermal discomfort but has yet to be shown to be ergogenic using single-spray applications. The authors examined whether repeated menthol spraying could relieve thermal discomfort, reduce perception of exertion, and improve exercise performance in hot (35°C), dry (22% relative humidity) conditions, hypothesizing that it would. Methods: A total of 8 trained cyclists completed 2 separate conditions of fixed-intensity cyclin

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Schiffmann, Jonas, Alessandro Larcher, Maxine Sun, et al. "Suboptimal use of pelvic lymph node dissection: Differences in guideline adherence between robot-assisted and open radical prostatectomy." Canadian Urological Association Journal 10, no. 7-8 (2016): 269. http://dx.doi.org/10.5489/cuaj.3563.

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<p><strong>Introduction:</strong> Our aim was to assess adherence to National Comprehensive Cancer Network (NCCN) and American Urological Association (AUA) guidelines for pelvic lymph node dissection (PLND) at the time of either robot-assisted (RARP) or open radical prostatectomy (ORP).</p><p><strong>Methods:</strong> We relied on the Surveillance, Epidemiology, and End Results-Medicare linked database and focused on localized prostate cancer (PCa) patients who were treated with either RARP or ORP between October 2008 and December 2009. Categorical and

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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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Zureigat, Hadil, Ahmed N. Mohamed, Muaz Alsabbagh Alchirazi, et al. "Cardiovascular Profile of Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia: A 16-Year Observational Study." Blood 144, Supplement 1 (2024): 1777. https://doi.org/10.1182/blood-2024-212146.

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Background: Chronic myelogenous leukemia (CML) is caused by a chromosomal translocation that gives rise to a chimeric BCR-ABL protein with constitutive tyrosine kinase (TK) activity. Tyrosine kinase inhibitors (TKIs) block this protein and have thus led to a paradigm shift in CML management in the early 2000s. Despite TKIs' efficacy in CML, their cardiotoxic side effects are a clinical challenge. This may result in TKI discontinuation and ultimately suboptimal response. Hence, we aim to explore the cardiotoxicity profile of TKIs, adjusting for pre-existing cardiovascular risk factors. Methods:

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Magrey, M., M. G. H. Van de Sande, M. Breban, et al. "POS1107 BIMEKIZUMAB ACHIEVED SUSTAINED IMPROVEMENTS IN EFFICACY OUTCOMES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS, REGARDLESS OF PRIOR TNF INHIBITOR TREATMENT: WEEK 52 POOLED RESULTS FROM TWO PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 876–77. http://dx.doi.org/10.1136/annrheumdis-2023-eular.836.

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BackgroundIn patients (pts) with axial spondyloarthritis (axSpA), tumour necrosis factor inhibitors (TNFi) are the usual first line biologic treatment, yet many pts may experience loss of response over time, and some are intolerant to TNFis.[1]Typically, response to second line biologics is limited in TNFi-inadequate responders (IR).Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In the phase 3 BE MOBILE 1 and 2 studies, BKZ treatment resulted in rapid and sustained improvements in efficacy outcomes through 52 weeks (wks) in pts with acti

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Tutt, Andrew, Judy Ellen Garber, Bella Kaufman, et al. "OlympiA: A phase III, multicenter, randomized, placebo-controlled trial of adjuvant olaparib after (neo)adjuvant chemotherapy in patients with germline BRCA1/2 mutations and high-risk HER2-negative early breast cancer." Journal of Clinical Oncology 39, no. 18_suppl (2021): LBA1. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.lba1.

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LBA1 Background: PARP inhibitors (PARPi) target cancers with homologous recombination repair defects by synthetic lethality. The PARPi olaparib (OL) is licensed for metastatic HER2-negative breast cancer with BRCA1/2 germline mutation (gBRCAm). Despite (neo)adjuvant chemotherapy ([N]ACT), recurrence rates in patients (pts) with gBRCAm early breast cancer (EBC) can be high. Novel adjuvant treatments are needed. Methods: OlympiA (NCT02032823), a randomized, double-blind, phase III study, enrolled pts with gBRCAm and HER2-negative (TNBC or hormone-receptor+ [HR+]) high-risk EBC after primary loca

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Cappellini, Maria Domenica, Norbert Gattermann, Vip Viprakasit, et al. "Transfusion History, Iron Chelation Practices and Status of Iron Overload across Various Transfusion-Dependent Anemias: Data from the Large- Scale, Prospective, 1-Year EPIC Trial." Blood 112, no. 11 (2008): 3880. http://dx.doi.org/10.1182/blood.v112.11.3880.3880.

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Abstract Background: The prospective, 1-yr multicenter EPIC trial evaluated the efficacy and safety of once-daily oral deferasirox (Exjade®) in more than 1700 patients (pts) with transfusion-dependent anemias. Data were collected from each patient at enrollment, providing an insight into transfusion history, body iron burden, and the nature and success of previous chelation therapy in a large group of pts with iron overload previously treated with chelation therapy. Methods: Enrolled pts were aged ≥2 yrs, had transfusion-dependent anemia and serum ferritin (SF) levels of ≥1000 ng/mL, or <10

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Kodali, Murali, James Shortridge, and Donald Doll. "Severe Hemolysis in Systemic Loxoscelism." Blood 124, no. 21 (2014): 4871. http://dx.doi.org/10.1182/blood.v124.21.4871.4871.

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Abstract Introduction: Brown recluse spider bites are encountered commonly in endemic areas of North and South America. Loxosceles reclusa is the species of Loxosceles most commonly seen in the states of MO, KS, OK, TX, AK, LA, KY, TN, MS, AL and parts of IL, IA, IN and GA. The incidence of hemolytic anemia with systemic loxoscelism in the USA seems to be significantly higher and more severe than the incidence and severity reported in studies from South America (13%-15% incidence). In our 6 cases of loxoscelism associated with severe hemolysis, we noticed that there are signs and symptoms that

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Franklin, Anders, Margareta Horn af Rantzien, Nils Obel, Karin Östensson, and Göran Åström. "Concentrations of penicillin, streptomycin, and spiramycin in bovine udder tissue liquids." American Journal of Veterinary Research 47, no. 4 (1986): 804–7. https://doi.org/10.2460/ajvr.1986.47.04.804.

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SUMMARY Concentrations of benzylpenicillin and spiramycin adipate were determined in bovine plasma and milk and in lymph draining the udder tissue after im or iv administration. Combined benzylpenicillin and dihydrostreptomycin sulfate concentrations were also determined in the same fluids after intramammary injection. A superficial parenchymal lymph vessel, afferrent to the supramammary lymph gland of the left quarters, was cannulated with a polythene catheter from which the lymph was allowed to drain freely. After injections of 9.5 mg of benzylpenicillin/kg of body weight im, a mean peak con

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Khanna, D., C. J. F. Lin, H. Spotswood, J. Siegel, D. Furst, and C. Denton. "THU0328 SAFETY AND EFFICACY OF SUBCUTANEOUS TOCILIZUMAB IN SYSTEMIC SCLEROSIS: RESULTS FROM THE OPEN-LABEL PERIOD OF THE PHASE 3 FOCUSSCED TRIAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 394.1–394. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1535.

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Background:The anti–interleukin-6 (IL-6) receptor-α antibody tocilizumab (TCZ) demonstrated skin score improvement and forced vital capacity (FVC) preservation in patients with systemic sclerosis (SSc) in a phase 2 randomized controlled trial.1,2Data from the 48-week, double-blind (DB), placebo (PBO)-controlled period of the focuSSced phase 3 trial were previously presented,3and open-label (OL) data up to week 96 are presented herein.Objectives:To assess the long-term safety and efficacy of TCZ in SSc patients.Methods:Adult patients with active SSc (≤60-month duration, modified Rodnan skin sco

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Bushev, Jane, Biljana Noveska-Petrovska, and Zoran Karatashev. "DIAGNOSTIC CONTRIBUTION OF CLOSED NEEDLE PLEURAL BIOPSY – A 10-YEAR RETROSPECTIVE ANALYSIS." MEDIS – International Journal of Medical Sciences and Research 1, no. 3 (2022): 11–17. http://dx.doi.org/10.35120/medisij010311b.

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Determining the etiology of a pleural effusion can present a major problem for the clinician. Diagnostic evaluation of pleural effusions should include relevant history, clinical course, radiographic abnormalities, and take into account the patient’s desire and consent for further invasive investigations. The seventies were dominated by specific pleural effusions, but in the last three decades effusions of malignant etiology have dominated. Despite advances in diagnostics, about 20% of pleural effusions remain etiologically unexplained. Objective: we present data on the diagnostic contribution

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Yang, Mo, Huixia Deng, Liuming Yang, et al. "Coagulation Dysfunction and Hematological Changes in 633 Patients with COVID-19." Blood 136, Supplement 1 (2020): 22–23. http://dx.doi.org/10.1182/blood-2020-140274.

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Background: A previously unknown beta-coronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the international committee for the classification of viruses (ICTV). The disease caused by this virus was named as coronavirus disease 2019 (COVID-19). In addition to pulmonary manifestations, hematological changes such as lymphocytopenia, thrombocytopenia, and coagulation dysfunction can also be found in COVID-19 patients, and the mechanism is still unclear. Case

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Mohan, Deepika, Baruch Fischhoff, Victor Talisa, et al. "An Educational Video Game in Trauma Triage at Nontrauma Centers." JAMA Network Open 8, no. 6 (2025): e2513375. https://doi.org/10.1001/jamanetworkopen.2025.13375.

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ImportanceUnderstanding how behavioral interventions work and whom they help can increase their effectiveness.ObjectiveTo evaluate the mechanism of action and heterogeneity of the estimated treatment effect of a customized video game (Night Shift) designed to recalibrate physician heuristics (pattern recognition) in trauma triage.Design, Setting, and ParticipantsThis process evaluation of a randomized clinical trial was performed with a national sample of 800 physicians responsible for the triage of patients with trauma at the emergency departments (EDs) of levels III, IV, and V trauma centers

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Suttorp, Meinolf, Ralf Knoefler, Hélène Deutsch, et al. "High Platelet Counts, Thrombosis, Bleeding Signs, and Acquired Von Willebrand Syndrome at Diagnosis of Pediatric Chronic Myeloid Leukemia." Blood 134, Supplement_1 (2019): 4152. http://dx.doi.org/10.1182/blood-2019-123343.

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Background: At diagnosis of chronic myeloid leukemia (CML) patients (pats) may present with elevated platelets (PLT) counts. Generally, high PLT counts may result in thrombosis and/or bleeding complications, the latter being due to binding of von Willebrand factor (VWF) multimers to platelets. Pediatric CML is very rare (Hijiya N, Suttorp M 2019; Blood 33:2374-2384) and no systematic investigation on clinical complications of elevated PLT counts has so far been reported. Methods: Data on PLT counts and associated thrombo-hemorrhagic complications were retrospectively analyzed in newly diagnose

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Devor, Daniel C., Robert J. Bridges та Joseph M. Pilewski. "Pharmacological modulation of ion transport across wild-type and ΔF508 CFTR-expressing human bronchial epithelia". American Journal of Physiology-Cell Physiology 279, № 2 (2000): C461—C479. http://dx.doi.org/10.1152/ajpcell.2000.279.2.c461.

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Forskolin, UTP, 1-ethyl-2-benzimidazolinone (1-EBIO), NS004, 8-methoxypsoralen (Methoxsalen; 8-MOP), and genistein were evaluated for their effects on ion transport across primary cultures of human bronchial epithelium (HBE) expressing wild-type (wt HBE) and ΔF508 (ΔF-HBE) cystic fibrosis transmembrane conductance regulator. In wt HBE, the baseline short-circuit current ( I sc) averaged 27.0 ± 0.6 μA/cm2 ( n = 350). Amiloride reduced this I sc by 13.5 ± 0.5 μA/cm2 ( n = 317). In ΔF-HBE, baseline I sc was 33.8 ± 1.2 μA/cm2 ( n = 200), and amiloride reduced this by 29.6 ± 1.5 μA/cm2 ( n = 116),

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