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Journal articles on the topic '355.009 44'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Akpek, Görgün, Marianna L. Zahurak, Steven Piantadosi, et al. "Development of a prognostic model for grading chronic graft-versus-host disease." Blood 97, no. 5 (2001): 1219–26. http://dx.doi.org/10.1182/blood.v97.5.1219.

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The disease-specific survival (DSS) of 151 patients with chronic graft-versus-host disease (cGVHD) was studied in an attempt to stratify patients into risk groups and to form a basis for a new grading of cGVHD. The data included the outcome and 23 variables at the diagnosis of cGVHD and at the primary treatment failure (PTF). Eighty-nine patients (58%) failed primary therapy for cGVHD. Nonrelapse mortality was 44% after a median follow-up of 7.8 years. The probability of DSS at 10 years after diagnosis of cGVHD (DSS1) and after PTF (DSS2) was 51% (95% confidence interval [CI] = 39%, 60%) and 3

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Brito, Paulo M., François J. Meunier, and Yuri M. Alves. "Reevaluation of the Perciformes from the Late Cretaceous Marília Formation of Brazil and its confirmation as a Siluriformes." Cybium 44, no. 4 (2020): 351–54. https://doi.org/10.26028/cybium/2020-444-005.

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Brito, Paulo M., Meunier, François J., Alves, Yuri M. (2020): Reevaluation of the Perciformes from the Late Cretaceous Marília Formation of Brazil and its confirmation as a Siluriformes. Cybium 44 (4): 351-354, DOI: 10.26028/cybium/2020-444-005, URL: http://dx.doi.org/10.26028/cybium/2020-444-005

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Rugo, Hope, Mark Robson, Seock-Ah Im, et al. "Abstract GS01-05: Pembrolizumab + Olaparib vs Pembrolizumab + Chemotherapy After Induction With Pembrolizumab + Chemotherapy for Locally Recurrent Inoperable or Metastatic TNBC: Randomized Open-Label Phase 2 KEYLYNK-009 Study." Cancer Research 84, no. 9_Supplement (2024): GS01–05—GS01–05. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs01-05.

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Abstract Background: Pembrolizumab (pembro) plus chemotherapy (chemo) showed statistically significant improvements in PFS and OS vs placebo + chemo in patients (pts) with previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC) whose tumors expressed PD-L1 with a combined positive score (CPS) ≥10 in the phase 3 KEYNOTE-355 study. Tolerable and effective maintenance regimens after induction therapy are needed to sustain clinical benefit. The PARP inhibitor olaparib is an established maintenance therapy for multiple platinum-sensitive tumor types and

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Soverini, Simona, Sabrina Colarossi, Alessandra Gnani, et al. "Frequency, Distribution and Prognostic Value of ABL Kinase Domain (KD) Mutations in Different Subsets of Philadelphia-Positive (Ph+) Patients (Pts) Resistant to Imatinib (IM) by the Gimema Working Party on CML." Blood 106, no. 11 (2005): 435. http://dx.doi.org/10.1182/blood.v106.11.435.435.

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Abstract Using denaturing-high performance liquid chromatography and sequencing, we screened for ABL KD mutations 319 IM-resistant Ph+ pts. Median time between diagnosis and IM start at 400–600 mg/d was 40 (0–160) months. Median duration of IM was 27 (9–62) months. Evaluable pts were 256/319 (80%). At the time of analysis, 178/256 (70%) pts were in chronic phase (CP)(36 previously untreated, 142 post-IFN failure), 16 (6%) pts were in accelerated phase (AP), 26 (10%) pts were in myeloid blast crisis (myBC), 36 (14%) were in lymphoid blast crisis (lyBC) or had Ph+ acute lymphoblastic leukemia (A

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5

Daniel, Emmanuel, Saada A. Seif, and Walter C. Millanzi. "Predictors of newborn hypothermia in the first 6 hours after delivery among newborns in Kilimanjaro region—Tanzania: An analytical cross-sectional study." Medicine 104, no. 17 (2025): e42018. https://doi.org/10.1097/md.0000000000042018.

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Maintaining a newborn body temperature after delivery is critical in achieving better newborn health outcomes. Properly controlling newborn temperature from the time of delivery can increase newborn survival. However, there is scant information on predictors associated with newborn hypothermia in the setting. A health facility-based analytical cross-sectional study was conducted from April to June 2024. The study included 325 newborns and their mothers from 4 primary health facilities, and the participants were selected using a systematic random sampling technique. The newborn axillary body te

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6

Rogers, Jonathan, Camarie Welgemoed, and Dorothy Gujral. "Does body mass index or subcutaneous adipose tissue thickness affect interfraction prostate motion in patients receiving radical prostate radiotherapy?" Journal of Radiotherapy in Practice 15, no. 4 (2016): 334–40. http://dx.doi.org/10.1017/s1460396916000364.

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AbstractAimIt is unclear whether body mass index (BMI) is a useful measurement for examining prostate motion. Patient’s subcutaneous adipose tissue thickness (SAT) and weight has been shown to correlate with prostate shifts in the left/right direction. We sought to analyse the relationship between BMI and interfraction prostate movement in order to determine planning target volume (PTV) margins based on patient BMI.Materials and methodsIn all, 38 prostate cancer patients with three implanted gold fiducial markers in their prostate were recruited. Height, mass and SAT were measured, and the ext

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Zucali, Paolo A., Matteo Simonelli, Fabio De Vincenzo, Armando Santoro, Antonio Lambiase, and Claudio Bordignon. "Changes in shedding of soluble tumor necrosis factor receptors (sR1/R2) and in dynamic MRI as early predictors of outcome with NGR-hTNF." Journal of Clinical Oncology 31, no. 15_suppl (2013): e22145-e22145. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22145.

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e22145 Background: Dose-response curve of NGR-hTNF, a selective antivascular agent, is typically biphasic with activity shown either at low dose (LD) or high dose (HD). Receptor shedding may block drug activity. Vascular effects at LD are characterized by early vessel stabilization and late vessel damage, while at HD by rapid vessel disruption. Methods: 60 pts (median age: 61; M/F: 44/16; PS 0/≥1: 25/35; median prior lines: 3) received in 2 ph I trials NGR-hTNF at LD (0.2-1.6 µg/m2; n=14) or HD (60-325 µg/m2; n=46) every 3 weeks. We tested the impact of early changes (post 1st dose) in baselin

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Wang, Jiali, Lijun Zhao, Junlin Zhang, et al. "CLINICOPATHOLOGIC FEATURES AND PROGNOSIS OF TYPE 2 DIABETES MELLITUS AND DIABETIC NEPHROPATHY IN DIFFERENT AGE GROUPS: MORE ATTENTION TO YOUNGER PATIENTS." Endocrine Practice 26, no. 1 (2020): 51–57. http://dx.doi.org/10.4158/ep-2019-0238.

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Objective: Our study sought to investigate the clinicopathologic features and renal prognosis of patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) in different age groups. Methods: A total of 315 patients with T2DM and biopsy-proven DN were enrolled and divided into three groups by age: the Youth group (≤44 years old), the Middle-aged group (45 to 59 years old), and the Elderly group (≥60 years old). Results: The Youth group, Middle-aged group, and Elderly group accounted for 19.05% (60/315), 59.37% (187/315), and 21.59% (68/315) of the patients in our study, respecti

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9

Paiva, Bruno, Norma C. Gutierrez, Xi Chen, et al. "Biological and Clinical Significance of CD81 Expression by Clonal Plasma Cells in High-Risk Smoldering and Symptomatic Multiple Myeloma (MM) Patients,." Blood 118, no. 21 (2011): 3936. http://dx.doi.org/10.1182/blood.v118.21.3936.3936.

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Abstract Abstract 3936 The presence of CD19 in myelomatous plasma cells (MM-PC) correlates with adverse prognosis in MM. Although CD19 expression is up-regulated by CD81, this marker has been poorly investigated and its prognostic value in myeloma remains unknown. Herein, we assessed the frequency and the prognostic value of the immunophenotypic detection of CD81 surface expression in MM-PC of high-risk smoldering (SMM) and symptomatic MM patients at diagnosis and its role as a potential therapeutic target. The study included 230 elderly MM patients treated according to the Spanish GEM05>65

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Heikura, Ida A., Louise M. Burke, Dan Bergland, Arja L. T. Uusitalo, Antti A. Mero, and Trent Stellingwerff. "Impact of Energy Availability, Health, and Sex on Hemoglobin-Mass Responses Following Live-High–Train-High Altitude Training in Elite Female and Male Distance Athletes." International Journal of Sports Physiology and Performance 13, no. 8 (2018): 1090–96. http://dx.doi.org/10.1123/ijspp.2017-0547.

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Purpose: The authors investigated the effects of sex, energy availability (EA), and health status on the change in hemoglobin mass (ΔHbmass) in elite endurance athletes over ∼3–4 wk of live-high–train-high altitude training in Flagstaff, AZ (2135 m; n = 27 women; n = 21 men; 27% 2016 Olympians). Methods: Precamp and postcamp Hbmass (optimized carbon monoxide rebreathing method) and iron status were measured, EA was estimated via food and training logs, and a Low Energy Availability in Females Questionnaire (LEAFQ) and a general injury/illness questionnaire were completed. Hypoxic exposure (h)

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Awada, Hassan, Cassandra M. Kerr, Vera Adema, et al. "The Clonal Trajectories of SF3B1 Mutations in Myeloid Neoplasia." Blood 136, Supplement 1 (2020): 8. http://dx.doi.org/10.1182/blood-2020-139528.

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Molecular lesions have diagnostic and prognostic impacts in myeloid neoplasia (MN). The beau idéal is the presence of SF3B1MT in MDS with ringed sideroblasts. Although most of these patients have a classic phenotype, little is known about the factors diverting it during the clonal evolution. Clinical trajectories of patients with SF3B1MT might depend on clonal hierarchy, dynamics and subclonal diversity in relation to other lesions. Herein, we studied the molecular architecture of patients with SF3B1MT to determine whether clonality and rank might infer distinct MDS features. We collected mole

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12

Fonseca, Rafael, Emily Blood, Montserrat Rue, et al. "Clinical and biologic implications of recurrent genomic aberrations in myeloma." Blood 101, no. 11 (2003): 4569–75. http://dx.doi.org/10.1182/blood-2002-10-3017.

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Abstract Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy chain locus (IgH). IgH translocations in MM result in the up-regulation of oncogenes, and include more commonly t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23). Based on the recurrent nature of these translocations and their finding since the early stages of the plasma cell (PC) disorders, we hypothesized that they would confer biologic and clinical variability. In addition, deletions of 13q14 and 17p13 have also been as

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Mora, O., J. L. Romano, E. González, F. J. Ruiz, R. Gómez та A. Shimada. "Presence of fed β-carotene in digesta, excreta, blood, and hepatic and adipose tissues of Holstein steers". Canadian Journal of Animal Science 81, № 1 (2001): 133–39. http://dx.doi.org/10.4141/a00-004.

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Eight animals were fed a diet without added β-carotene for 49 d and then supplemented with four levels of β-carotene (0, 5.5, 44 or 352 mg kg–1dry matter) for 30 d; the two-phase procedure was then repeated. Steers were killed at the end of the second period. Concentrations of β-carotene were: 0, 0, 227.2 and 2011 mg dL–1 (P < 0.05) in ruminal fluid; 0, 0, 533.7 and 4418 mg dL–1 (P < 0.05) in duodenal fluid; 0, 4.03, 14.91 and 90.64 mg g–1 (P < 0.05) in dry faeces; 0.8, 1.2, 4.7 and 8.1 mg g–1 (P < 0.05) in liver; 0.07, 0.15, 0.5 and 3.7 mg g–1 (P < 0.05) in subcutaneous fat; 0,

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14

Farquhar, Douglas R., Maheer M. Masood, Andrew K. Pappa, Samip N. Patel, and and Trevor G. Hackman. "Predictors of Adverse Outcomes in Free Flap Reconstruction: A Single-Institution Experience." Otolaryngology–Head and Neck Surgery 159, no. 6 (2018): 973–80. http://dx.doi.org/10.1177/0194599818787801.

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Objective Understanding the independent predictors of poor outcomes in free flap surgery is essential for patient selection. We aim to determine the independent predictors of major complications, flap survival, and extended hospital stays. Study Design Retrospective cohort study. Setting Tertiary medical center. Subjects and Methods We reviewed medical records from all vascularized tissue transfers in the head and neck between 2007 and 2014 at our institution. We recorded demographics, medical comorbidities, disease characteristics, flap characteristics, and intraoperative events. We defined o

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15

Katsanis, E., PM Anderson, AH Filipovich, et al. "Proliferation and cytolytic function of anti-CD3 + interleukin-2 stimulated peripheral blood mononuclear cells following bone marrow transplantation." Blood 78, no. 5 (1991): 1286–91. http://dx.doi.org/10.1182/blood.v78.5.1286.1286.

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Abstract We evaluated the proliferation, cytolytic function, and phenotypic characteristics of anti-CD3 plus interleukin-2 (IL-2) stimulated peripheral blood mononuclear cells (PBMCs) from 44 patients with leukemia or non-Hodgkin's lymphoma (NHL) treated with multiagent chemotherapy or following bone marrow transplantation (BMT). BMT patients had decreased cell growth with only a 1.35 +/- 0.25 (autologous BMT for acute lymphoblastic leukemia [ALL]), 1.24 +/- 0.25 (autologous BMT for NHL), and 0.8 +/- 0.1 (allogeneic BMT for leukemia) mean fold increase by day 5 of culture compared with control

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16

Katsanis, E., PM Anderson, AH Filipovich, et al. "Proliferation and cytolytic function of anti-CD3 + interleukin-2 stimulated peripheral blood mononuclear cells following bone marrow transplantation." Blood 78, no. 5 (1991): 1286–91. http://dx.doi.org/10.1182/blood.v78.5.1286.bloodjournal7851286.

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We evaluated the proliferation, cytolytic function, and phenotypic characteristics of anti-CD3 plus interleukin-2 (IL-2) stimulated peripheral blood mononuclear cells (PBMCs) from 44 patients with leukemia or non-Hodgkin's lymphoma (NHL) treated with multiagent chemotherapy or following bone marrow transplantation (BMT). BMT patients had decreased cell growth with only a 1.35 +/- 0.25 (autologous BMT for acute lymphoblastic leukemia [ALL]), 1.24 +/- 0.25 (autologous BMT for NHL), and 0.8 +/- 0.1 (allogeneic BMT for leukemia) mean fold increase by day 5 of culture compared with controls (4.0 +/

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17

Zhan, Fenghuang, Bart Barlogie, Varant Arzoumanian, et al. "A Gene Expression Signature of Benign Monoclonal Gammopathy Evident in Multiple Myeloma Is Linked to Good Prognosis." Blood 108, no. 11 (2006): 3393. http://dx.doi.org/10.1182/blood.v108.11.3393.3393.

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Abstract Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM), often through a phase of smoldering MM (SMM). We hypothesized that a molecular signature of MGUS may be detectable in a subset of patients with MM. Applying Significance Analysis of Microarrays, 52 genes, involved in important pathways related to cancer, were found to be differentially expressed between plasma cells from 22 healthy subjects, 24 strictly defined MGUS/SMM and 351 symptomatic MM (P < .001). Unsupervised hierarchical clustering of 351 MM and 44 cases of MGUS and 16 cases of

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18

Krishnaswami, Sumi, Anant K. Agarwal, Jim Richmond, et al. "High Temperature Characterization of 4H-SiC Bipolar Junction Transistors." Materials Science Forum 527-529 (October 2006): 1437–40. http://dx.doi.org/10.4028/www.scientific.net/msf.527-529.1437.

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This paper summarizes the recent demonstration of 3200 V, 10 A BJT devices with a high common emitter current gain of 44 in the linear region, and a specific on-resistance of 8.1 mΩ- cm2 (10 A at 0.90 V with a base current of 350 mA and an active area of 0.09 cm2). The onresistance increases to 40 mΩ-cm2 at 350°C, while the DC current gain decreases to 30. A sharp avalanche behavior was observed with a leakage current of 10 μA at a collector voltage of 3.2 kV.

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19

Atabani, G. S., B. O. Saeed, E. M.-A. El Mahdi, M. E. Adam, and D. A. Hassan. "Glycated Haemoglobin and other Biochemical Parameters in Sudanese Diabetics." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 26, no. 4 (1989): 332–34. http://dx.doi.org/10.1177/000456328902600406.

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Fasting levels of glycated haemoglobin, cholesterol and triglycerides were studied in 44 patients with non-insulin-dependent diabetes mellitus (NIDDM), 31 patients with insulin-dependent diabetes mellitus (IDDM) and 28 healthy Sudanese individuals. Results confirmed previous observations showing correlation of glycated haemoglobin with fasting blood glucose in NIDDM ( r=0·634; P < 0·001), and with cholesterol in IDDM ( r=0·355; P < 0·05). No correlation of glycated haemoglobin with triglycerides was observed in either group of diabetics. A negative correlation was demonstrated between gl

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20

Virappane, Priya, Rosemary Gale, Robert Hills, et al. "Mutation of the Wilms’ Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party." Journal of Clinical Oncology 26, no. 33 (2008): 5429–35. http://dx.doi.org/10.1200/jco.2008.16.0333.

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Purpose To determine the clinical relevance of Wilms’ tumor 1 (WT1) gene mutations in acute myeloid leukemia (AML) with normal karyotype (NK). Patients and Methods Exons 7 and 9 of WT1 were screened in samples from 470 young adult NK AMLs using a combination of direct sequencing and high-resolution capillary electrophoresis. Results Overall, 51 mutations were detected in 47 cases (10%): 46 frameshift mutations with insertion/deletion of one to 28 base pairs in exon 7 (n = 45) or exon 9 (n = 1), with a median mutant level of 45% (range, 8% to 86%), and five substitutions in exon 9: D396N (n = 3

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Reis, A. M., M. Jankowski, S. Mukaddam-Daher, J. Tremblay, T.-V. Dam, and J. Gutkowska. "Regulation of the natriuretic peptide system in rat uterus during the estrous cycle." Journal of Endocrinology 153, no. 3 (1997): 345–55. http://dx.doi.org/10.1677/joe.0.1530345.

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Abstract Uterine natriuretic peptides may be involved in the alterations that occur in the uterus during the estrous cycle through its role in hydromineral balance. The following studies were performed to determine whether uterine natriuretic peptides and receptors follow a cyclic pattern during the estrous cycle. The results obtained show that atrial natriuretic peptide (ANP) content in rat uterine tissue was low in proestrus (8·5 ± 2·6 pg/g) and significantly increased (P<0·001) in estrus (71·5 ± 16·6 pg/g), metestrus (82·6 ± 19·7 pg/g) and diestrus (91·0 ± 19·4 pg/g), whereas plasma ANP

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Orenburkina, O. I. "EDOF IOL implantation in combination of cataract and stabilized glaucoma." Modern technologies in ophtalmology 2, no. 4 (2024): 253–54. http://dx.doi.org/10.25276/2312-4911-2024-4-253-254.

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Актуальность. Катаракта и первичная открытоугольная глаукома (ПОУГ) — ведущие причины слепоты в мире, их доля в глазной заболеваемости достигает 50,0 и 13 %. Сочетанный характер данной патологии наблюдается в 13–76 % случаев. Цель. Провести анализ результатов факоэмульсификации (ФЭК) с имплантацией ИОЛ с расширенной глубиной фокуса (EDOF) пациентам при сочетании катаракты и ПОУГ. Материал и методы. Прооперировано 12 пациентов (18 глаз) с катарактой и ПОУГ, проведена ФЭК с имплантацией EDOF ИОЛ. В 56 % случаев проведена билатеральная коррекция, в 44 % случаях — монолатеральная. Средний возраст

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Yalniz, Fevzi F., Rima M. Saliba, Orhan K. Yucel, et al. "Somatic Mutations Improve Risk Classification By Cytogenetic Abnormalities in Patients with Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 512. http://dx.doi.org/10.1182/blood-2019-125937.

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Background: Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for patients with myelodysplastic syndrome (MDS) but disease progression after HSCT remains a major reason for failure after transplant. Identification of risk factors for progression of MDS after HSCT would allow to identify target population for early initiation of preventive treatments to improve outcomes. Methods: Patients with a diagnosis of MDS who received first HSCT between 2013 and 2018 with available pre-transplant genetic profile obtained from next generation sequencing of genes were inclu

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Summers, MPH, April D., Elizabeth C. Ailes, PhD, Michele K. Bohm, MPH, et al. "Opioid prescription claims among women aged 15-44 years—United States, 2013-2017." Journal of Opioid Management 17, no. 2 (2021): 125–33. http://dx.doi.org/10.5055/jom.2021.0623.

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Objective: To estimate the annual percentage of women of reproductive age with private insurance or Medicaid who had opioid prescription claims during 2013-2017 and describe trends over time.Design: A secondary analysis of insurance claims data from IBM MarketScan® Commercial and Multi-State Medicaid Databases to assess outpatient pharmacy claims for prescription opioids among women aged 15-44 years during 2013-2017.Participants: Annual cohorts of 3.5-3.8 million women aged 15-44 years with private insurance and 0.9-2.1 million women enrolled in Medicaid.Main Outcome Measure: The percentage of

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Thiel, Bram, Jamey Blaauboer, Chiem Seesing, et al. "Patient self-reported pain and nausea via smartphone following day care surgery, first year results: An observational cohort study." PLOS Digital Health 3, no. 7 (2024): e0000342. http://dx.doi.org/10.1371/journal.pdig.0000342.

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Contact with the hospital is usually limited for patients after day care surgery. Dedicated smartphone applications can improve communication and possibly enhance outcomes. The objective of this retrospective study was to evaluate patients’ self-reported pain and nausea and assess the success of routine implementation of a smartphone application for outcome reporting. During preoperative assessment, patients were instructed to download and activate the smartphone application to report pain, nausea and to be in contact with the hospital after discharge. Main outcome was the number of patients a

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Haddad, Firas, and Joanna S. Saade. "Performance of ChatGPT on Ophthalmology-Related Questions Across Various Examination Levels: Observational Study." JMIR Medical Education 10 (January 18, 2024): e50842. http://dx.doi.org/10.2196/50842.

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Background ChatGPT and language learning models have gained attention recently for their ability to answer questions on various examinations across various disciplines. The question of whether ChatGPT could be used to aid in medical education is yet to be answered, particularly in the field of ophthalmology. Objective The aim of this study is to assess the ability of ChatGPT-3.5 (GPT-3.5) and ChatGPT-4.0 (GPT-4.0) to answer ophthalmology-related questions across different levels of ophthalmology training. Methods Questions from the United States Medical Licensing Examination (USMLE) steps 1 (n

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Zhan, Fenghuang, Bart Barlogie, Varant Arzoumanian, et al. "Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis." Blood 109, no. 4 (2006): 1692–700. http://dx.doi.org/10.1182/blood-2006-07-037077.

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Abstract Monoclonal gammopathy of undetermined significance (MGUS) can progress to multiple myeloma (MM). Although these diseases share many of the same genetic features, it is still unclear whether global gene-expression profiling might identify prior genomic signatures that distinguish them. Through significance analysis of microarrays, 52 genes involved in important pathways related to cancer were differentially expressed in the plasma cells of healthy subjects (normal plasma-cell [NPC]; n = 22) and patients with stringently defined MGUS/smoldering MM (n = 24) and symptomatic MM (n = 351) (

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Osofsky, Robin, Ross Clark, Jaideep Das Gupta, et al. "The effect of preoperative embolization on surgical outcomes for carotid body tumor resection." SAGE Open Medicine 9 (January 2021): 205031212110052. http://dx.doi.org/10.1177/20503121211005229.

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Objective: Compare the effects of preoperative embolization for carotid body tumor resection on surgical outcomes to carotid body tumor resections without preoperative embolization. Methods: Single-center retrospective review of all consecutive patients who underwent carotid body tumor resection from 2001 to 2019. Surgical outcomes with emphasis on operative time (estimated blood loss and cranial nerve injury) of patients undergoing carotid body tumor resection following preoperative embolization were compared to those undergoing resection alone using unpaired Student’s t-test and Fisher’s exa

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Demetriou, Eleni, and Roee Holtzer. "Mild Cognitive Impairments Moderate the Effect of Time on Verbal Fluency Performance." Journal of the International Neuropsychological Society 23, no. 1 (2016): 44–55. http://dx.doi.org/10.1017/s1355617716000825.

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AbstractObjectives: Mild cognitive impairments (MCI) is a transitional state in aging associated with increased risk of incident dementia. The current study investigated whether MCI status moderated the effect of time on word generation during verbal fluency tasks. Specifically, the objective was to determine whether MCI status had differential effects on initial automatic or latter more effortful retrieval processes of fluency tasks. Methods: Participants were community residing older adults enrolled in a longitudinal cohort study. Of the 408 participants, 353 were normal (age=76.06±6.61; %fe

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Hehlmann, Rüdiger, Michael Lauseker, Susanne Jung-Munkwitz та ін. "Tolerability-Adapted Imatinib 800 mg/d Versus 400 mg/d Versus 400 mg/d Plus Interferon-α in Newly Diagnosed Chronic Myeloid Leukemia". Journal of Clinical Oncology 29, № 12 (2011): 1634–42. http://dx.doi.org/10.1200/jco.2010.32.0598.

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Purpose Treatment of chronic-phase (CP) chronic myeloid leukemia (CML) with imatinib 400 mg/d can be unsatisfactory. Optimization of treatment is warranted. Patients and Methods In all, 1,014 newly diagnosed CP-CML patients were randomly assigned to imatinib 800 mg/d (n = 338), imatinib 400 mg/d (n = 325), or imatinib 400 mg/d plus interferon alfa (IFN-α; n = 351). Dose adaptation to avoid higher-grade toxicity was recommended. First primary end point was major molecular remission (MMR) at 12 months. Results A higher rate of MMR at 12 months occurred with tolerability-adapted imatinib 800 mg/d

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Scully, Mary-Frances, David MacGregor, Meghan Walsh, Brendan Barrett, Marc Kawaja, and Charlotte Sheppard. "The Clinical Impact of Mild Hemophilia A, Report of a Cohort Study." Blood 106, no. 11 (2005): 3210. http://dx.doi.org/10.1182/blood.v106.11.3210.3210.

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Abstract Due to a founder affect certain regions of the Canadian province of Newfoundland and Labrador have a very high prevalence of mild Hemophilia A. To accurately plan for future health related needs of these patients, a base-line cross-sectional study of a large cohort segregating a known founder mutation (Val2016Ala) was undertaken. Characteristics of Study Participants Characteristic Affected Males Control Males P-Values (Affected vs Control) Carrier Females Control Females P-Value (Carrier vs Control) Values are expressed as number, mean*, median(interquartile range)†, or percentage Ov

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Saju, Leya, Debra Rosenbaum, Deanne Wilson-Costello, Katherine Slain, Anne Stormorken, and Steven L. Shein. "Acute Neuro-Functional Morbidity Upon Discharge From the Pediatric Intensive Care Unit After Critical Bronchiolitis." Hospital Pediatrics 12, no. 4 (2022): 353–58. http://dx.doi.org/10.1542/hpeds.2021-006166.

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BACKGROUND AND OBJECTIVE Improved survival has shifted research focus toward understanding alternate PICU outcomes, including neurocognitive and functional changes. Bronchiolitis is a common PICU diagnosis, but its neuro-functional outcomes have not been adequately described in contemporary literature. The objective of the study is to describe the epidemiology and associated clinical characteristics of acute neuro-functional morbidity (ANFM) in critical bronchiolitis. METHODS Patients &lt;2 years old admitted with bronchiolitis between 2014 and 2016 were identified. Demographics, medical h

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Kumanthem, P., L. Kumar, D. Janga, et al. "Recurrent epithelial ovarian cancer (EOC): What determines the outcome?" Journal of Clinical Oncology 24, no. 18_suppl (2006): 15003. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.15003.

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15003 Background: Recurrent EOC is a common clinical problem and treatment is not curative. We retrospectively analyzed the data on 354 patients with recurrent EOC to determine the impact of various prognostic factors on outcome. Methods: Between August, 1989 and June, 2005, 354 patients (median age 49 years, range, 28 to 80 years) were diagnosed as recurrent EOC. 259 patients received chemotherapy alone, 44 were treated with combination of secondary debulking surgery and chemotherapy or radiotherapy. Remaining 51 (14.4%) patients had no treatment. Main types of salvage chemotherapy included-

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Chouhab, Y., T. Lefebvre, C. Forestier, P. Parsis, and M. Martinez. "Analyse des courriers de plainte adressés au service d’urgence d’un centre hospitalier général." Annales françaises de médecine d’urgence 9, no. 6 (2019): 362–68. http://dx.doi.org/10.3166/afmu-2019-0176.

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Objectif : L’objectif principal de notre travail était d’analyser les courriers de plainte (CP) adressés à un service d’urgence (SU). L’objectif secondaire était de déterminer s’il existait une corrélation entre CP et temporalité de passage au SU. Matériel et méthodes : Étude rétrospective monocentrique sur six ans portant sur les CP concernant les prises en charge en SU. Résultats : Quatre-vingt-un CP ont été analysés, la moyenne annuelle et l’incidence étaient de 13,5 CP/an et de 5,5 CP/ 10 000 passages. L’incidence était de 3,5 CP/10 000 passages pour les enfants vs 6,1 CP/10 000 passages p

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Portuguese, Andrew J., Sherilyn A. Tuazon, Margot J. Pont, et al. "Gamma Secretase Inhibition May Mitigate the Impact of Low BCMA Target Density in Relapsed/Refractory Multiple Myeloma: Results from a Comparative Analysis of Two Phase 1 Clinical Trials." Blood 144, Supplement 1 (2024): 4832. https://doi.org/10.1182/blood-2024-205942.

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The safety and clinical activity of FCARH143, an autologous CAR-T cell product with a human BCMA-specific scFv and a 4-1BB costimulatory domain, has been evaluated in adult patients (pts) with relapsed/refractory multiple myeloma (R/R MM) in two single-arm phase I trials with similar eligibility criteria (contemporaneously accruing at the same center), FH9952 (n=18) and FH9762 (n=25), at dose levels of 50-450 ×106 CAR+ cells. Pts on FH9952 received the γ-secretase inhibitor (GSI), crenigacestat, during a pre-CAR-T run-in (3 doses 48 h apart) followed by post-infusion dosing 3x weekly for up to

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Holm, Jan, Steen Ingemann Hansen, and Mimi Høier-Madsen. "A high-affinity folate binding protein in human amniotic fluid. Radioligand binding characteristics, immunological properties and molecular size." Bioscience Reports 10, no. 1 (1990): 79–85. http://dx.doi.org/10.1007/bf01116855.

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The presence of a folate binding protein of high-affinity type (affinity constant 5 · 109M−1, maximum folate binding 3 nM) in human amniotic fluid was demonstrated in equilibrium dialysis experiments (37°C, pH 7.4) with the radioligand3H-folate. Dissociation of3H-folate from the binding protein was slow at pH 7.4 but rapid at pH 3.5. By use of rabbit antibodies against low molecular weight folate binding protein from human milk we determined the concentration of folate binding protein in 5 amniotic fluids (range 1.5–2.3 nM) in an Enzyme-Linked Immunosorbent Assay (ELISA). ultrogel AcA 44 chrom

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Mohan, Sanjay R., Paul Elson, Ramon V. Tiu, et al. "Duration of Antecedent Complete Blood Cell Count (CBC) Abnormalities Predicts Response and Survival Rates In De Novo and Secondary AML." Blood 116, no. 21 (2010): 1040. http://dx.doi.org/10.1182/blood.v116.21.1040.1040.

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Abstract Abstract 1040 Introduction: Secondary acute myeloid leukemia (sAML) is a heterogeneous disease classification comprising patients (pts) with a history of myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPN) and pts with prior exposure to chemotherapy or radiation. Though sAML pts typically have lower complete remission (CR) and worse overall survival (OS) rates with induction chemotherapy, it is unknown whether pts with antecedent CBC abnormalities but without formal hematologic diagnoses prior to AML display similar poor outcomes. Methods: We retrospectively evaluate

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Wattel, E., A. Guerci, B. Hecquet, et al. "A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group." Blood 88, no. 7 (1996): 2480–87. http://dx.doi.org/10.1182/blood.v88.7.2480.bloodjournal8872480.

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We performed a randomized study of hydroxyurea (HY) versus VP16 in advanced chronic myelomonocytic leukemia (CMML) patients with CMML (according to French-American-British group criteria) and either documented visceral involvement (excluding liver and spleen infiltration) or at least 2 of the following: (1) neutrophils &gt; 16 x 10(9)/I (2) Hemoglobin &lt; 10 g/dL (3) platelets &lt; 100 x 10(9)/L (4) marrow blasts &gt; 5% (5) spleen &gt; 5 cm below costal margin were eligible for this trial. Initial dosage was 1 g/d for HY and 150 mg/week for VP16, orally (doubled in case o

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Porro, A., T. Luster, C. Gao, et al. "0197 Chronotype is Influenced by Behavioral Choices and Can Fluctuate Across the Semester in STEM Students." Sleep 43, Supplement_1 (2020): A77—A78. http://dx.doi.org/10.1093/sleep/zsaa056.195.

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Abstract Introduction A delay in endogenous biological rhythms is assumed to cause undergraduate students to be “night owls,” but neurodevelopmental effects may only partially explain chronotype (circadian preference). Instead, perceived chronotype in students may result from poor sleep hygiene practices including bedtime social media use, afternoon caffeine consumption, and daytime napping. If so, then chronotype should be malleable in students to the extent that behavioral choices change. Methods We surveyed 1,120 undergraduate students who were enrolled in STEM courses across up to 3 time p

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Bardet, Stéphane, Renaud Ciappuccini, Elske Quak, et al. "Prognostic Value of Microscopic Lymph Node Involvement in Patients With Papillary Thyroid Cancer." Journal of Clinical Endocrinology & Metabolism 100, no. 1 (2015): 132–40. http://dx.doi.org/10.1210/jc.2014-1199.

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Abstract Context: The impact of microscopic nodal involvement on the risk of persistent/recurrent disease (PRD) remains controversial in patients with papillary thyroid carcinoma (PTC). Objective: The goal of the study was to assess the risk of PRD and the 4-year outcome in PTC patients according to their initial nodal status [pNx, pN0, pN1 microscopic (cN0/pN1) or pN1 macroscopic (cN1/pN1)]. Design: We conducted a retrospective cohort study. Patients: The study included 305 consecutive PTC patients referred for radioiodine ablation from 2006 to 2011. Main Outcome Measure: We evaluated the ris

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Belli, Carolina, Ronald Feitosa Pinheiro, Maria Gabriela Flores, et al. "Clinical Characteristics and Prognosis in South-American Patients with Myelodysplastic Syndrome: A Multicenter Study." Blood 124, no. 21 (2014): 4651. http://dx.doi.org/10.1182/blood.v124.21.4651.4651.

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Abstract There are previous reported data describing differences between European and Asian patients with Myelodysplastic Syndromes (MDS), and little is known about South-American (SA) patients. Our aim was to describe clinical characteristic of SA MDS population, to compare our series with diverse ethnicity, to evaluate scoring systems and prognostic factors. We retrospectively analysed a series of 1080 patients with de novo MDS (1981-2014) from Argentine (Ar-635), Brazil (Br-345), and Chile (Ch-100). Patients were classified following FAB and WHO criteria, excluding patients with bone marrow

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Virappane, Priya, Rosemary E. Gale, Robert Hills, et al. "Mutation of the Wilms’ Tumor 1 Gene Is a Poor Prognostic Factor Associated with Chemoresistance in Normal Karyotype Acute Myeloid Leukemia." Blood 110, no. 11 (2007): 361. http://dx.doi.org/10.1182/blood.v110.11.361.361.

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Abstract The Wilms’ tumour 1 (WT1) gene is highly expressed in various types of leukemia, suggesting a role both as a target for immunotherapy and a means for monitoring minimal residual disease. More recently WT1 has been recognised as an important mutational target in normal karyotype (NK) acute myeloid leukemia (AML), with clustering of mutations to exons 7 and 9. In this study, we set out to determine the clinical relevance of these mutations. Diagnostic DNA samples were obtained from peripheral blood or bone marrow of 470 young adult AML patients entered into the UK Medical Research Counc

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Marquez, Carina, Andrew D. Kerkhoff, John Schrom, et al. "COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 Periods." JAMA Network Open 5, no. 10 (2022): e2235844. http://dx.doi.org/10.1001/jamanetworkopen.2022.35844.

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ImportanceCharacterizing the clinical symptoms and evolution of community-based SARS-CoV-2 infections may inform health practitioners and public health officials in a rapidly changing landscape of population immunity and viral variants.ObjectivesTo compare COVID-19 symptoms among people testing positive with a rapid antigen test (RAT) during the Omicron BA.1 variant period (December 1, 2021, to January 30, 2022) with the pre-Delta (January 10 to May 31, 2021) and Delta (June 1 to November 30, 2021) variant periods and to assess the duration of RAT positivity during the Omicron BA.1 surge.Desig

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Ellis, Matthew J., Yu Tao, Oliver Young, et al. "Estrogen-Independent Proliferation Is Present in Estrogen-Receptor HER2-Positive Primary Breast Cancer After Neoadjuvant Letrozole." Journal of Clinical Oncology 24, no. 19 (2006): 3019–25. http://dx.doi.org/10.1200/jco.2005.04.3034.

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Purpose To investigate the impact of human epidermal growth factor receptor (HER) 1 and HER2 gene amplification on endocrine therapy responsiveness, a fluorescence in situ hybridization (FISH) study was conducted on tumor samples from 305 postmenopausal patients with stage II and III estrogen receptor (ER) –positive (ER ≥ 10%) breast cancers treated on two independent neoadjuvant endocrine therapy trials. Patients and Methods FISH analysis focused on HER1 and/or HER2 immunohistochemistry (IHC) -positive patients and a random selection of HER1/2 IHC-negative patients. HER2 FISH status was corre

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Ohnuma, Hiroyuki, Yasushi Sato, Ginji Omori, et al. "Survival benefit of conversion therapy after intensive chemotherapy for unresectable metastatic gastric cancer: A propensity score-matched analysis." Journal of Clinical Oncology 38, no. 4_suppl (2020): 354. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.354.

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354 Background: The significance of conversion therapy (CT), whereby patients (pts) with unresectable disease respond to chemotherapy and subsequently receive surgery with curative intent (adjuvant surgery: AS), has been specifically established for metastatic colorectal cancer. However, such a strategy for advanced or recurrent gastric cancer (AGC) remains controversial. This study aims to clarify the clinical significance of CT for AGC. Methods: In this retrospective multi-institution observational study, we analyzed 168 AGC pts who received chemotherapy consisting of docetaxel, cisplatin or

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Abrisqueta, Pau, Graham W. Slack, David W. Scott, et al. "Outcome of Observation As Initial Strategy in Patients with Mantle Cell Lymphoma." Blood 126, no. 23 (2015): 2699. http://dx.doi.org/10.1182/blood.v126.23.2699.2699.

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Abstract Background Patients with mantle cell lymphoma (MCL) follow a heterogeneous clinical course ranging from very indolent to very aggressive. While patients with MCL generally require treatment initiation shortly after diagnosis, it is unclear whether deferring treatment in patients with "indolent" MCL affects their overall outcome. Because it is difficult to identify such patients at the time of diagnosis, their course can only be retrospectively described as indolent after a prolonged period of observation. The aim of this study was to describe the subgroup of patients with MCL who unde

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Balcells, J., M. Fondevila, J. A. Guada, C. Castrillo, and J. C. E. Surra. "Urinary excretions of purine derivatives and nitrogen in sheep given straw supplemented with different sources of carbohydrates." Animal Science 57, no. 2 (1993): 287–92. http://dx.doi.org/10.1017/s0003356100006905.

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AbstractEstimations of purine derivatives excretion and urinary-nitrogen loss were used to test the response of rumen fermentation to supplementation of straw with different sources of carbohydrate. Two groups of Rasa Aragonesa ewes (44 (s.e. 0·75) kg live weight were given ad libitum basal diets of either ammonia-treated (ATS) or urea-supplemented (USS) barley straw, with 12 animals per basal diet group. Three supplements, barley grain, sugar-beet pulp or grass hay, respectively, were given to each basal diet group, giving a total of six dietary treatments with four animals per treatment grou

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Borthakur, Gautam, Nitin Jain, Hagop Kantarjian, et al. "Survival Is Poorer in Patients with Secondary Core Binding Factor Acute Myelogenous Leukemia Compared with De Novo Core Binding Factor Leukemia." Blood 110, no. 11 (2007): 2856. http://dx.doi.org/10.1182/blood.v110.11.2856.2856.

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Abstract Translocation (8;21)(q22;q22) and inversion of chromosome 16 [inv(16) (p13q22)] are considered good-risk cytogenetic abnormalities in acute myeloid leukemia (AML) accounting for 15% of primary AML cases (Blood. 2002 Dec 15;100(13):4325–36) and are characterized at the molecular level by disruption of genes encoding subunits of core binding factor (CBF). Increasing age, increasing peripheral blast percentage and complex cytogenetics are associated with poor overall survival in these patients (Br J Haematol. 2006 Oct;135(2):165–73). Here we assess differences in patient characteristics

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Frendak, Lynn S., Scott M. Wright, and David Shih Wu. "The Effect of a Standardized Triage Process on Efficiency and Productivity of an Inpatient Palliative Care Team." American Journal of Hospice and Palliative Medicine® 37, no. 6 (2019): 413–17. http://dx.doi.org/10.1177/1049909119876928.

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Context: Studies have shown that palliative care involvement delivers a multitude of benefits to patients and caregivers. The existing palliative care workforce is inadequate to meet growing demand. Innovative strategies to triage inpatient consults are necessary. Objectives: To describe the implementation of a new palliative care triage process and to demonstrate its impact on efficiency, teamwork, and patient care. Methods: A quasi-experimental study design, comparing clinical consult data from a 6-month period before and a 6-month period after implementation of the novel consult triage mode

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Darwash, A. O., G. E. Lamming, and M. D. Royal. "A protocol for initiating oestrus and ovulation earlypost partumin dairy cows." Animal Science 72, no. 3 (2001): 539–46. http://dx.doi.org/10.1017/s1357729800052073.

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AbstractThe objective of the present study was to evaluate the efficacy of a prostaglandin F2α(PGF2α) and progesterone (P4) treatment in initiating oestrus and ovulation post partum (PP) in Holstein-Friesian cows. Using four herds, the treatment protocol consisted of a single intra-muscular injection of PGF2α(Estrumate) between days 12 to 14 PP followed 48 h later by progesterone treatment via intra-vaginal CIDR insertion for a period of 7 days. Milk samples for progesterone determination were collected three times weekly from 7 to 65 days PP. The ovarian activity and reproductive performance

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