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Journal articles on the topic '364.138 082'

Author: Grafiati

Published: 4 May 2024

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1

Almström, Markus, Johannes Jacks, Pia Malmquist, et al. "Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study." European Journal of Pediatric Surgery 30, no. 04 (2019): 350–56. http://dx.doi.org/10.1055/s-0039-1687870.

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Introduction Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection of proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission is a diagnostic marker for perforation in children with AA. Materials and Methods This was a prospective diagnostic accuracy study, including previously healthy children, 1 to 14 years of age, with AA. Blood sampling included plasma sodium concentration, plasma glucose, base excess, white blood cell count, plasma arginine vasopressin

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Mattheussen, M., K. Mubagwa, B. F. Rusy, H. Van Aken, and W. Flameng. "Potentiated state contractions in isolated hearts: effects of ischemia and reperfusion." American Journal of Physiology-Heart and Circulatory Physiology 264, no. 5 (1993): H1663—H1673. http://dx.doi.org/10.1152/ajpheart.1993.264.5.h1663.

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To investigate mechanisms underlying the contractile dysfunction during myocardial "stunning," potentiated contractions were studied in Langendorff-perfused rabbit hearts paced at 2.5 Hz. Isovolumetric left ventricular pressure (LVP) and the first derivative of LVP (dP/dt) were measured via a balloon. Potentiated contractions, elicited after 3 s of rest (postrest potentiation, PRP) or with paired pulses (paired-pulse potentiation, PPP) were first characterized in nonischemic conditions. Exposure to 5 nM ryanodine changed PRP into postrest depression [control, 134 +/- 1.7% (SE); ryanodine, 65 +

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Derakhshande-Rishehri, Seyede-Masome, Marjan Mansourian, Roya Kelishadi, and Motahar Heidari-Beni. "Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis." Public Health Nutrition 18, no. 11 (2014): 2041–54. http://dx.doi.org/10.1017/s1368980014002262.

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AbstractObjectiveThe present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies.DesignSystematic review and meta-analysis.SettingSearch process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect si

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Zylbersztejn, Ania, Ruth Gilbert, Anders Hjern, and Pia Hardelid. "Origins of disparities in preventable child mortality in England and Sweden: a birth cohort study." Archives of Disease in Childhood 105, no. 1 (2019): 53–61. http://dx.doi.org/10.1136/archdischild-2018-316693.

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ObjectiveTo compare mortality in children aged <5 years from two causes amenable to healthcare prevention in England and Sweden: respiratory tract infection (RTI) and sudden unexpected death in infancy (SUDI).DesignBirth cohort study using linked administrative health databases from England and Sweden.Setting and participantsSingleton live births between 2003 and 2012 in England and Sweden, followed up from age 31 days until the fifth birthday, death or 31 December 2013.Main outcome measuresThe main outcome measures were HR for RTI-related mortality at 31–364 days and at 1–4 years and SUDI

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O'Doherty, J. V., and T. F. Crosby. "Blood metabolite concentrations in late pregnant ewes as indicators of nutritional status." Animal Science 66, no. 3 (1998): 675–83. http://dx.doi.org/10.1017/s1357729800009243.

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AbstractIn a feeding experiment β-hydroxybutyrate (BHB), glucose, albumin, total protein, globulin and urea concentrations in the plasma of twin-bearing ewes were analysed. Mature Suffolk cross ewes were given either formic acid (FA)-treated grass silage or grasslmolassed sugar-beet pulp (MSBP) silage in late pregnancy. The experiment commenced on day 91 of pregnancy and the dietary treatments were FA-treated silage (Tl), FA-treated silage + soya-bean meal (SBM) (T2), MSBP silage (T3), MSBP silage + SBM (T4), FA-treated silage + MSBP (T5), FA-treated silage + MSBP + SBM (T6) or FA-treated sila

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Lines, A., S. B. Hooper, and R. Harding. "Lung liquid production rates and volumes do not decrease before labor in healthy fetal sheep." Journal of Applied Physiology 82, no. 3 (1997): 927–32. http://dx.doi.org/10.1152/jappl.1997.82.3.927.

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Lines, A., S. B. Hooper, and R. Harding. Lung liquid production rates and volumes do not decrease before labor in healthy fetal sheep. J. Appl. Physiol. 82(3): 927–932, 1997.—Previous studies have suggested that the volume and production rate of fetal lung liquid decrease late in gestation, before the onset of labor, in preparation for the clearance of lung liquid at birth. In contrast, our earlier studies have not shown a decrease in lung liquid volume near term, although these studies were not continued to the onset of labor. Our aim was to determine the changes in lung liquid volume and pro

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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8

Jwo, Ching Song, Lung Yue Jeng, Ho Chang, and Sih Li Chen. "Research of Vacuum Pump with Nano-Lubricant." Key Engineering Materials 364-366 (December 2007): 867–72. http://dx.doi.org/10.4028/www.scientific.net/kem.364-366.867.

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This study used the Al2O3 nano-lubricant produced from the direct synthesis method was used as the experimental samples and the ultrasonic vibration was used for dispersing the nanoparticles into three types of the weight fraction (0.1, 0.2, 0.3%wt). The base solvent was the lubricant of vacuum pump. The objectives of this study were to discuss the dependence of operating temperature of vacuum pump under the various weight fraction of Al2O3 nanoparticles. In this experiment we added Al2O3 nano-lubricant into the direct drive oil sealed rotary vacuum pump, and used the thermocouple measure the

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Phan, Kevin, Khushdeep S. Vig, Yam Ting Ho, et al. "Age Is a Risk Factor for Postoperative Complications Following Excisional Laminectomy for Intradural Extramedullary Spinal Tumors." Global Spine Journal 9, no. 2 (2018): 126–32. http://dx.doi.org/10.1177/2192568218754512.

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Study Design: Retrospective analysis. Objective: The incidence of intradural extramedullary (IDEM) spinal tumors is increasing. Excisional laminectomy for removal and decompression is the standard of care, but complications associated with patient age are unreported in the literature. Our objective is to identify if age is a risk factor for postoperative complications after excisional laminectomy of IDEM spinal tumors. Methods: A retrospective analysis was performed on the 2011 to 2014 ACS-NSQIP (American College of Surgeons National Surgical Quality Improvement Program) database for patients

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Wang, Wen, Linghua Wang, Säm Krucker, and Robert F. Wimmer-Schweingruber. "Energy Spectrum of Solar Energetic Electron Events over 25 Years." Astrophysical Journal 948, no. 1 (2023): 51. http://dx.doi.org/10.3847/1538-4357/acbea2.

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Abstract We investigate the peak flux energy spectrum of 458 solar energetic electron (SEE) events with a clear velocity dispersion detected at energies from ≤4.2 to ≥108 keV by Wind/3DP from 1994 December through 2019 December, utilizing a pan-spectrum fitting method. According to the fitted spectral parameters, these 458 events are self-consistently classified into five spectral types: 304 downward double-power-law (DDPL) events, 32 upward double-power-law (UDPL) events, 23 single-power-law (SPL) events, 44 Ellison–Ramaty (ER) events, and 55 logarithmic–parabola (LP) events. The DDPL events

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Nielson, D. W. "Electrolyte composition of pulmonary alveolar subphase in anesthetized rabbits." Journal of Applied Physiology 60, no. 3 (1986): 972–79. http://dx.doi.org/10.1152/jappl.1986.60.3.972.

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We measured the concentration of Na+, K+, Ca2+, and Cl- in the aqueous subphase of the alveolar lining by puncturing the most superficial alveoli of the exposed lungs of anesthetized rabbits with ion-selective microelectrodes and a nonselective KCl microelectrode. A buffered electrolyte solution bathed the lung surface to keep it moist and warm (38 +/- 1 degrees C) and to serve as a reference for each measurement of ionic concentration. The serum and alveolar concentrations (meq/l) were Na+ 134 +/- 6 and 135 +/- 5, K+ 3.4 +/- 0.2 and 7.3 +/- 0.7, Ca2+ 3.1 +/- 0.2 and 3.2 +/- 0.4, and Cl- 106 +

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Heimlich, Jonathan Brett, Godwin Chipoka, Portia Kamthunzi, et al. "Establishing Sickle Cell Diagnostics and Characterizing a Pediatric Sickle Cell Disease Cohort in Malawi." Blood 126, no. 23 (2015): 2070. http://dx.doi.org/10.1182/blood.v126.23.2070.2070.

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Abstract Sickle cell disease (SCD) is highly prevalent in sub-Saharan Africa; however, there are relatively few studies describing the clinical profile for children with laboratory-confirmed SCD. Prior to December 2014, neither neonatal screening nor standardized methods for SCD diagnosis were routinely available in Malawi, as hemoglobin electrophoresis and alternative diagnostic methods were absent. We describe implementation of hemoglobin electrophoresis for children with clinically suspected SCD at Kamuzu Central Hospital, one of two national teaching hospitals in Malawi. Children with clin

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Luong, Huu Thanh, Thuy Nga Vu, Thi Thuy Ha, Kieu Bang Tam Nguyen, and Thi Hong Van Dao. "Effects of some microelements on antifungal activity and biomass of the Actinomyces producing Validamycin-A." Journal of Vietnamese Environment 9, no. 3 (2018): 128–31. http://dx.doi.org/10.13141/jve.vol9.no3.pp128-131.

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Validamycin A (Val-A) is an aminoglycoside's antibiotic with anti-fungal activity. Val-A synthesized by Streptomyces hygroscopicus strain depending on the growth and development of this actinomyces. In this study, the effects of Mn and Zn on the antifungal activity and biomass of the Streptomyces hygroscopicus were conducted. The results showed that micronutrients Mn, Zn had significant effects on biomass as well as antifungal activity of strain Streptomyces hygroscopicus-DA15. With the addition of Mn at a concentration of 1μg/l of the nutrient medium, biomass of Streptomyces hygroscopicus was

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Hauswirth, C., J. Fitschen, E. Martin, G. Oetting, H. Hundeshagen, and Ch Ehrenheim. "Zum genetischen Risiko nach hochdosierter Radiojodtherapie unter Berücksichtigung der Gonadendosis." Nuklearmedizin 36, no. 05 (1997): 157–66. http://dx.doi.org/10.1055/s-0038-1629786.

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Zusammenfassung Ziel der vorliegenden Arbeit ist die Abschätzung des genetischen Risikos nach hochdosierter Radiojodtherapie unter besonderer Berücksichtigung der individuell erreichten Gonadendosis. Methode: Mittels eines Erhebungsbogens wurden die Daten von insgesamt 364 Patientinnen und Patienten mit einem differenzierten Schilddrüsenkarzinom im gebärbzw. zeugungsfähigen Alter bezüglich ihrer Nachkommen ausgewertet. 45 Patienten (41 Frauen und vier Männer) aus dieser Gruppe hatten insgesamt 56 Kinder. Der Verlauf von Schwangerschaft, Geburt und Kindesentwicklung wurde erfaßt. Ergebnisse: Im

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Kantarjian, Hagop M., Richard A. Larson, Francois Guilhot, Stephen G. O’Brien, and Brian J. Druker. "Declining Rates of Adverse Events (AEs), Rare Occurrence of Serious AEs (SAEs), and No Unexpected Long-Term Side Effects at 5 Years in Patients with Newly Diagnosed Chronic Myeloid Leukemia (CML) in Chronic Phase (CP) Initially Treated with Imatinib (IM) in the International Randomized Study of Interferon vs STI571 (IRIS)." Blood 108, no. 11 (2006): 2136. http://dx.doi.org/10.1182/blood.v108.11.2136.2136.

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Abstract The IRIS trial compared interferon alfa + cytarabine (IFN+Ara-C) and imatinib (IM) in patients (pts) with newly diagnosed CML-CP. Among 553 pts randomized to receive 400 mg IM, 157 (28%) discontinued for reasons which included AEs or deaths unrelated to CML and treatment (6%) and unsatisfactory therapeutic effect (11%). Only 2.4% discontinued due to drug-related AEs. The average daily dose was 389±71 mg, suggesting that no major dose modifications were required due to toxicity. In pts still on IM, the average doses was 382±50 mg. Average duration of exposure is 50 mos (median 60 mos).

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McCartney, Christopher R., Melissa Gilrain, Jessica A. Lundgren, Su Hee Kim, and Christine Michele Burt Solorzano. "Assessment of Estradiol-Induced Gonadotropin Surge Generation: Preliminary Results From a Protocol of Graded Transdermal Estradiol Dosing." Journal of the Endocrine Society 5, Supplement_1 (2021): A729—A730. http://dx.doi.org/10.1210/jendso/bvab048.1484.

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Abstract In normally-cycling women, high midcycle estradiol (E2) concentrations (&gt; 200-300 pg/ml) derived from the dominant follicle trigger an approximately 10-fold increase in LH and 4-fold increase in FSH levels—the gonadotropin surge—over about 48 hours. In prenatally-androgenized female rats and sheep (animal models with polycystic ovary syndrome [PCOS]-like features), high-dose estrogen fails to initiate gonadotropin surges. However, it remains unclear whether E2-induced gonadotropin surge generation is defective in PCOS. Baird et al., induced LH surges in 12 women with PCOS and 6

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Ha, Heon-Young, Jae Jang, Tae-Ho Lee, et al. "Investigation of the Localized Corrosion and Passive Behavior of Type 304 Stainless Steels with 0.2–1.8 wt % B." Materials 11, no. 11 (2018): 2097. http://dx.doi.org/10.3390/ma11112097.

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The pitting corrosion resistance and passive behavior of type 304 borated stainless steels (Febalance–18Cr–12Ni–1.5Mn–(0.19, 0.78, and 1.76 wt %)B) manufactured through conventional ingot metallurgy were investigated. The alloys were composed of an austenitic matrix and Cr2B phase, and the volume fraction of Cr2B increased from 1.68 to 22.66 vol % as the B content increased from 0.19 to 1.76 wt %. Potentiodynamic polarization tests measured in aqueous NaCl solutions revealed that the pitting corrosion resistance was reduced as the B content increased and the pits were initiated at the matrix a

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Tilchenko, D. A., E. Yu Bibik, K. A. Frolov, et al. "The effect of new partially hydrogenated pyridines, cyanothioacetamide derivatives, on the liver morphological parameters in rats with dexamethasone-induced diabetes mellitus." Journal of Siberian Medical Sciences 7, no. 1 (2023): 118–31. http://dx.doi.org/10.31549/2542-1174-2023-7-1-118-131.

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Introduction. On the basis of the Chemex Scientific Lab of the Vladimir Dahl Lugansk State University we have synthesized and selected 4 samples of partially hydrogenated pyridine derivatives via in silico screening, containing a furan fragment in the fourth position (codenamed cv-150, cv-140, cv-083 and jen09-039), the effect of which on the course of dexamethasone-induced diabetes mellitus (DM) is of interest. Aim. To study the morphological parameters of the liver of dexamethasone-induced diabetic rats during a period of pronounced senile changes in the setting of pharmacological treatment

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Dominietto, Alida, Teresa Lamparelli, Anna Maria Raiola, et al. "Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation." Blood 100, no. 12 (2002): 3930–34. http://dx.doi.org/10.1182/blood-2002-01-0339.

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We have studied the impact of cell dose on short- and long-term graft function and outcome in 905 patients undergoing an unmanipulated allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling (n = 735), a one-antigen mismatched related donor (n = 35), or a matched unrelated donor (n = 135). Median number of nucleated cells infused was 3.4 × 108/kg (25th percentile 2.4 × 108/kg, 75th percentile 5 × 108/kg). Patients were stratified according to cells infused in 3 groups: ≤ 2.4 × 108/kg (n = 247; low dose); >2.4 × 108/kg and ≤ 5 × 108/kg (n = 452; intermediate dose); and &gt

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Guglielmelli, Paola, Flavia Biamonte, Johannah Score, et al. "Prognostic Impact of EZH2 and ASXL1 Mutation in Myelofibrosis." Blood 118, no. 21 (2011): 2811. http://dx.doi.org/10.1182/blood.v118.21.2811.2811.

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Abstract Abstract 2811 Among chronic myeloproliferative neoplasms (MPN) myelofibrosis (MF) has the worst prognosis. The International Prognostic Score System-IPSS reliably discriminates four categories of patients (pts) with different survival (OS); however, the possibility to identify pts with very high-risk disease, based on intrinsic characteristics of the underlying disease, would be particularly useful for therapeutic choices that include early stem cell transplantation. Several studies have addressed the prognostic value of molecular abnormalities harbored by MF pts, but a part from a ne

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Harshman, Lauren Christine, Yu-Hui Chen, Glenn Liu, et al. "Lower PSA at 7 months is prognostic for improved overall survival (OS) in metastatic hormone sensitive prostate cancer (mHSPC) treated with ADT with and without docetaxel (D)." Journal of Clinical Oncology 35, no. 6_suppl (2017): 137. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.137.

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137 Background: Prior work from SWOG 9346 revealed that PSA ≤ 0.2 ng/dL at 7 months (mo) is prognostic for longer OS with ADT alone. We sought to evaluate if this optimal decline remained predictive of better OS when D was added to ADT for initial mHSPC treatment. Methods: We performed a landmark survival analysis at 7 mo using the E3805 database (NCT00309985). Inclusion required at least 7 mo of followup and PSA levels at 7 mo from ADT initiation. Survival was defined from ADT start or randomization to death. SWOG 9346 PSA nadirs of ≤ 0.2, > 0.2-4 and > 4 were used as classifiers. Resul

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Lammers-van der Holst, H. M., Y. Zhang, L. K. Barger, et al. "0382 Sex Differences in Sleep and Quality of Life in Healthcare Shift Workers." Sleep 43, Supplement_1 (2020): A146—A147. http://dx.doi.org/10.1093/sleep/zsaa056.379.

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Abstract Introduction Shift work is associated with insufficient and disrupted sleep and impaired quality of life due to misalignment between the timing of internal biological clock and work/sleep schedule. There are reported sex differences in the circadian timing system, in sleep, and in reported sleep complaints, but how these impact female shift workers remains unclear. Furthermore, relatively little is known about sex differences in quality of life in shift workers. The objective of this study is to investigate sex differences in sleepiness, insomnia and quality of life in healthcare shif

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Powles, Thomas, Ajjai Shivaram Alva, Mustafa Ozguroglu, et al. "Post hoc pooled analysis of first-line (1L) pembrolizumab (pembro) for advanced urothelial carcinoma (UC): Outcomes by response at week nine in KEYNOTE-052 and KEYNOTE-361." Journal of Clinical Oncology 40, no. 6_suppl (2022): 519. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.519.

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519 Background: Pembro is a 1L treatment for cisplatin-ineligible pts with UC. This post hoc landmark analysis evaluated clinical outcomes by response at 9 wk to 1L pembro monotherapy in pts with advanced/unresectable or metastatic UC from the single-arm phase 2 KEYNOTE-052 (NCT02335424) and the randomized phase 3 KEYNOTE-361 (NCT02853305) trials. Methods: Cisplatin-ineligible pts with advanced UC were enrolled in KEYNOTE-052 and received pembro (200 mg Q3W for ≤2 y). Platinum-eligible pts with advanced UC who had not previously received systemic chemotherapy (chemo) were enrolled in KEYNOTE-3

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Rodriguez, Lisette Patricia, Vida Farhangi, Julaine Braham, Robert A. Smith, and Wilhelmine Wiese-Rometsch. "In-Hospital Glycemic Dysregulation Associated With Worse Outcomes in COVID-19." Journal of the Endocrine Society 5, Supplement_1 (2021): A346. http://dx.doi.org/10.1210/jendso/bvab048.705.

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Abstract Introduction: Evidence establishes that COVID-19 patients with DM2 are at increased risk for severe disease and worse outcomes. Peer reviewed data is sparse comparing glycemic control and clinical outcomes among COVID-19 patients with vs. without DM2, and thus we sought to address this gap. Methods: We selected patients at least 18 years old who expired or were discharged between March 16, 2020 through September 15, 2020. Principal analysis compared glycemic patterns among patients with DM2 vs. non-DM2. Median, coefficient of variation (CV), maximum and minimum glucose parameters were

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Tang, Junwang. "(Invited, Digital Presentation) Methane Conversion to High Value Chemicals By Photocatalysis." ECS Meeting Abstracts MA2022-02, no. 48 (2022): 1815. http://dx.doi.org/10.1149/ma2022-02481815mtgabs.

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As underlined in the COP26, methane as a greenhouse gas is nearly 80 time more potent than CO2 while its reserve is much more than the sum of coal, oil and natural gas. Thus methane conversion not only involves the environmental issue but also is related to high-value chemical production /clean energy supply, which has been attracting substantial interest over the last decades. However CH4 activation is energy intensive and kinetically very challenging so that methane activation is regarded as the “holy grail” in the catalytically chemical process. [1] Photocatalysis provides a cost efficient

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Maksymowych, W. P., U. Weber, X. Baraliakos, et al. "POS0032 SCORING MRI STRUCTURAL LESIONS IN SACROILIAC JOINTS OF PATIENTS WITH AXIAL SPONDYLOARTHRITIS: HOW MANY SLICES ARE OPTIMAL?" Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 221.1–221. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3427.

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Background:There is no international consensus on the optimal number of slices for evaluation of MRI structural lesions in the SIJ. An “all slice” method evaluates lesions from the most anterior slice, defined as the first slice with vertical height of ≥1cm of the SIJ joint cavity, up to the most posterior slice, defined as the most posterior slice where ≥1cm vertical height of the cartilaginous portion is still visible. The SPARCC method scores the transitional slice between cartilaginous and ligamentous compartments as the first slice and then an additional 4 slices anterior to the transitio

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De Lima, José Ayron Moraes, Elizanilda Ramalho Do Rêgo, Joabe Freitas Crispim, et al. "Diversidade e seleção em população segregante de pimenteiras ornamentais (Capsicum annuum L.)." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 12 (2023): 23486–99. http://dx.doi.org/10.55905/oelv21n12-002.

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O crescente interesse por pimenteiras ornamentais é motivado pela grande variedade observada em uma série de características, incluindo tamanho, folhagem, cor do fruto e arquitetura apropriada. Por meio da caracterização morfológica, é possível acessar a diversidade genética de um acervo de um banco de germoplasma que estão disponíveis para uso em programas de melhoramento genético. Portanto, o presente trabalho teve como objetivo avaliar a diversidade genética dentro em geração F2 em pimenteira ornamental (Capsicum annuum L) e indicar genótipos para a abertura de linha em geração F3. O experi

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Jasonsmith, J. F., W. Maher, A. C. Roach, and F. Krikowa. "Selenium bioaccumulation and biomagnification in Lake Wallace, New South Wales, Australia." Marine and Freshwater Research 59, no. 12 (2008): 1048. http://dx.doi.org/10.1071/mf08197.

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Selenium concentrations were measured in water, sediments and organisms inhabiting a freshwater coal power station cooling reservoir. Se concentrations found were: water, 1.9 ± 2 μg L–1; sediment, 7 ± 1 μg g–1; phytoplankton, 3.4 μg g–1; zooplankton, 5.3 μg g–1; epiphytic algae, 1.3 ± 0.2 μg g–1; benthic algae, 8 ± 2 μg g–1; macrophyte leaves, 2.7–2.8 μg g–1; macrophyte roots, 0.5–6.5 μg g–1; detritus, 10 μg g–1; Oligochaeta, 11 μg g–1; Corbiculidae, 1.1 μg g–1; Insects, 3.7–8.3 μg g–1; Gastropoda, 3.2 μg g–1; Crustacea, 3.1–6 μg g–1; whole fish, 2.2–13 μg g–1; and fish liver, 134–314 μg g–1.

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Carrenho-Sala, L. C., A. Garcia-Guerra, R. V. Sala, et al. "102 UNILATERAL AND BILATERAL TRANSFER OF 2IN VITRO-PRODUCED EMBRYOS INCREASES PREGNANCY LOSS BETWEEN 30 AND 60 DAYS." Reproduction, Fertility and Development 29, no. 1 (2017): 159. http://dx.doi.org/10.1071/rdv29n1ab102.

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Fertility of in vitro-produced embryos is affected by embryo stage and quality. Embryos quality 1 and stage 7 result in higher fertility than embryos of earlier stages and/or lower quality. The objective was to evaluate the effect of unilateral and bilateral transfer of 2 in vitro-produced embryos of earlier stages and/or poor quality on fertility. Heifers were synchronized using a 5-day CIDR Synch or 2 prostaglandin F2α injections 14 days apart followed by oestrus detection. Embryo transfer was performed 7 ± 1 day after gonadotropin-releasing hormone/oestrus and heifers were assigned randomly

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Hill, Timothy A., Jennette A. Sakoff, Phillip J. Robinson, and Adam McCluskey. "Parallel Solution-Phase Synthesis of Targeted Tyrphostin Libraries with Anticancer Activity." Australian Journal of Chemistry 58, no. 2 (2005): 94. http://dx.doi.org/10.1071/ch04143.

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The combination of semi-automation, an elegant synthesis, and parallel solution-phase synthesis approaches has allowed the development of five targeted, symmetrical tyrphostin compound libraries. These libraries on average are comprised of 12 compounds. Notwithstanding this, low micromolar potent growth inhibitors against HT29 (colorectal carcinoma) and G401 (renal carcinoma) cell lines were discovered. Additionally, significant SAR data was obtained. We noted that the most potent growth inhibitory activity was consistently observed for those analogues that possessed a 2-chlorophenyl (for 10:

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Gogate, Anagha, Amanda Crosbie, Trong Kim Le, Ying Zhang, Rolee Das, and Catherine Davis. "Abstract P3-12-15: Clinical characteristics, treatment patterns, and survival outcomes in women with early triple-negative (TN) or hormone receptor-positive/human epidermal growth factor receptor-2 negative (HR+/HER2−) breast cancer (BC) in the real-world (RW) setting." Cancer Research 82, no. 4_Supplement (2022): P3–12–15—P3–12–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-12-15.

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Abstract Background: BC remains the most commonly diagnosed cancer for women. TNBC is an aggressive form with a poorer prognosis compared with other subtypes. Neoadjuvant therapy (NAT) is the standard-of-care approach to shrink tumors in the breast and axilla and to improve patient outcomes. Few RW studies exist of US patients with early BC (eBC); this study aimed to describe clinical parameters by receipt of systemic therapy and to assess overall survival (OS) and progression-free survival (PFS) after NAT and adjuvant therapy (AT) in women with early HR+/HER2− or TNBC using RW evidence in the

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Joseph, S. A., and D. W. Walker. "Monoamine concentrations in cerebrospinal fluid of fetal and newborn sheep." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 2 (1994): R472—R480. http://dx.doi.org/10.1152/ajpregu.1994.266.2.r472.

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Monoamine concentrations were measured in cisternal cerebrospinal fluid (CSF) of unanesthetized fetal (115-135 days gestation) and newborn (2-34 days old) sheep. Norepinephrine (NE) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations decreased with gestational age; NE CSF concentrations were significantly higher in the newborn (336.4 +/- 61.7 pg/ml; n = 5) compared with the 131- to 135-day-gestation fetuses (104.0 +/- 46.3 pg/ml, n = 3; P < 0.05). Dopamine (DO), homovanillic acid (HVA), and serotonin (5-HT) concentrations in fetal CSF did not change with gestational age, and epinephri

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Redeker, I., S. Moustakis, S. Tsiami, et al. "AB0823 TREATMENT WITH ADALIMUMAB IN PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: A STUDY OF TREATMENT TRAJECTORIES ON A PATIENT LEVEL IN CLINICAL PRACTICE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1435.2–1436. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1838.

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Background:There is evidence that drug retention rates to adalimumab (ADA) in patients (pts.) with chronic inflammatory rheumatic diseases (CIRD) are impaired by loss of efficacy and adverse events, and that about 50% of users had discontinued ADA within 5 years (1). With the introduction of ADA biosimilars in October 2018, non-medical switching from originator to ADA biosimilars is now increasingly part of daily practice in rheumatologic care.Objectives:The aim was to study treatment trajectories over two years in pts. with CIRD receiving originator ADA.Methods:Pts. with CIRD on originator AD

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Lee, Donna, and Preeti Kishore. "Pituitary Metastasis Presenting With Central Diabetes Insipidus and Panhypopituitarism." Journal of the Endocrine Society 5, Supplement_1 (2021): A601. http://dx.doi.org/10.1210/jendso/bvab048.1225.

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Abstract Background: Metastatic involvement of the pituitary gland and infundibular stalk is rare, accounting for about 2% of all diagnosed pituitary masses. Although primary tumors from almost every organ have been reported, breast and lung cancers are the most common primary tumors to metastasize to the pituitary gland. The clinical presentation varies and can include headache, visual impairment, diabetes insipidus, and panhypopituitarism. The posterior lobe of the pituitary is more susceptible to metastatic involvement than the anterior lobe due to its direct blood supply from the systemic

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Klein Goldewijk, Kees, Arthur Beusen, Jonathan Doelman, and Elke Stehfest. "Anthropogenic land use estimates for the Holocene – HYDE 3.2." Earth System Science Data 9, no. 2 (2017): 927–53. http://dx.doi.org/10.5194/essd-9-927-2017.

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Abstract. This paper presents an update and extension of HYDE, the History Database of the Global Environment (HYDE version 3.2). HYDE is an internally consistent combination of historical population estimates and allocation algorithms with time-dependent weighting maps for land use. Categories include cropland, with new distinctions for irrigated and rain-fed crops (other than rice) and irrigated and rain-fed rice. Grazing lands are also provided, divided into more intensively used pasture and less intensively used rangeland, and further specified with respect to conversion of natural vegetat

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Lorenz, John N., Patrick J. Schultheis, Timothy Traynor, Gary E. Shull, and Jürgen Schnermann. "Micropuncture analysis of single-nephron function in NHE3-deficient mice." American Journal of Physiology-Renal Physiology 277, no. 3 (1999): F447—F453. http://dx.doi.org/10.1152/ajprenal.1999.277.3.f447.

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The Na/H exchanger isoform 3 (NHE3) is expressed in the proximal tubule and thick ascending limb and contributes to the reabsorption of fluid and electrolytes in these segments. The contribution of NHE3 to fluid reabsorption was assessed by micropuncture in homozygous ( Nhe3 −/−) and heterozygous ( Nhe3 +/−) knockout mice, and in their wild-type (WT, Nhe3 +/+) littermates. Arterial pressure was lower in the Nhe3 −/−mice (89 ± 6 mmHg) compared with Nhe3 +/+ (118 ± 4) and Nhe3 +/−(108 ± 5). Collections from proximal and distal tubules demonstrated that proximal fluid reabsorption was blunted in

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Urude, R. O., G. A. Amuga, R. J. Ombugado, W. A. ,. Oyibo, and J. O. Nebe. "The effect of physico chemical parameter on the distribution of fresh water snails in the Federal Capital Territory, Abuja, Nigeria." Nigerian Journal of Parasitology 42, no. 2 (2021): 302–10. http://dx.doi.org/10.4314/njpar.v42i2.15.

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Some species of freshwater snails are known to be intermediate hosts of biomedical importance. This study was conducted to identify some physico-chemical parameters of water bodies associated with the distribution of freshwater snail species in the Federal Capital Territory, Abuja. Eight water bodies in four locations were surveyed for the presence of freshwater snails. Five physico chemical parameters (pH, temperature, dissolved oxygen content, salinity and water speed) were measured using standard water meters. A correlation matrix between the water parameters and the snail species were anal

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PHILLIPS, DAVID, KATHRYN BRIDGER, IAN JENSON, and JOHN SUMNER. "An Australian National Survey of the Microbiological Quality of Frozen Boneless Beef and Beef Primal Cuts." Journal of Food Protection 75, no. 10 (2012): 1862–66. http://dx.doi.org/10.4315/0362-028x.jfp-12-135.

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The fourth national baseline microbiological survey of Australian beef was conducted in 2011, including frozen boneless beef and, for the first time, samples from selected beef primal cuts. Cartons of frozen boneless beef (n = 1,165) sampled at 29 boning (fabrication) plants were found to have a mean total viable count of 2.2 log CFU/g, and the mean count for the 2.1% of samples with detectable Escherichia coli was 1.3 log CFU/g. The mean total viable counts for striploins (longissimus dorsi, n = 572) and outsides (biceps femoris, n = 572) were 1.3 and 1.5 log CFU/cm2 respectively. E. coli iso

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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Nigro, Giovanni, Stuart P. Adler, Stefania Lasorella, et al. "High-Dose Cytomegalovirus (CMV) Hyperimmune Globulin and Maternal CMV DNAemia Independently Predict Infant Outcome in Pregnant Women With a Primary CMV Infection." Clinical Infectious Diseases 71, no. 6 (2019): 1491–98. http://dx.doi.org/10.1093/cid/ciz1030.

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Abstract Background After primary maternal cytomegalovirus (CMV) infection during pregnancy, infants are at risk for disease. Methods Factors predictive of infant outcome were analyzed in a database of 304 pregnant women with primary infection. These women were enrolled between 2010 and 2017 and delivered 281 infants, of whom 108 were CMV infected. Long term follow-up occurred for 173 uninfected and 106 infected infants at age 4 years (range, 1–8 years). One hundred fifty-seven women were treated with an average of 2 doses (range, 1–6 doses) of high-dose hyperimmune globulin (HIG: 200 mg/kg/in

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Balaji, Aanika, Stephanie Leigh Alden, Howard Li, et al. "Incidence, risk factors, and outcomes of immune-related adverse events (irAEs) in a prospective, pan-tumor population." Journal of Clinical Oncology 41, no. 16_suppl (2023): 2662. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2662.

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2662 Background: IrAEs associated with immune checkpoint inhibitors (ICIs) can result in morbidity and mortality. The incidence, spectrum, and risk factors for irAEs are usually reported from retrospective studies and clinical trials, which typically exclude patients (pts) with pre-existing autoimmune disease (AD). The prevalence and risk factors for irAEs in a diverse, pan-tumor, real-world setting is not well understood. Methods: From 06/2021 to 2/2023, we prospectively enrolled pts receiving ICIs (alone or in combination as standard-of-care) at a tertiary care center in this imCORE network

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Vassilakos, George, Rob S. James, and Valerie M. Cox. "Effect of stimulation frequency on force, net power output, and fatigue in mouse soleus muscle in vitro." Canadian Journal of Physiology and Pharmacology 87, no. 3 (2009): 203–10. http://dx.doi.org/10.1139/y09-002.

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The effects of electrical stimulation frequency on force, work loop power output, and fatigue of mouse soleus muscle were investigated in vitro at 35 °C. Increasing stimulation frequency did not significantly affect maximal isometric tetanic stress (overall mean ± SD, 205 ± 16.6 kN·m–2 between 70 and 160 Hz) but did significantly increase the rate of force generation. The maximal net power output during work loops significantly increased with stimulation frequency: 18.2 ± 3.7, 22.5 ± 3.3, 26.8 ± 3.7, and 28.6 ± 3.4 W·kg–1 at 70, 100, 130, and 160 Hz, respectively. The stimulation frequency tha

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Min, Hyang K., Hyun Y. Ko, Jin T. Kim, Lise Bankir, and Sung W. Lee. "Low hydration status may be associated with insulin resistance and fat distribution: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2010." British Journal of Nutrition 124, no. 2 (2020): 199–208. http://dx.doi.org/10.1017/s0007114520001063.

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AbstractWe aimed to identify the association of hydration status with insulin resistance (IR) and body fat distribution. A total of 14 344 adults participated in the Korea National Health and Nutrition Examination Survey 2008–2010. We used urine specific gravity (USG) to indicate hydration status, and HOMA-IR (homoeostasis model assessment of IR) and trunk:leg fat ratio (TLR) as primary outcomes. In multivariate logistic regression, the OR per 0·01 increase in USG for high IR was 1·303 (95 % CI 1·185, 1·433; P < 0·001). In multivariate generalised additive model plots, increased USG showed

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Choi, Rihwa, Sang Gon Lee, and Eun Hee Lee. "Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population." Diagnostics 13, no. 20 (2023): 3194. http://dx.doi.org/10.3390/diagnostics13203194.

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We investigated the reference intervals for Apolipoprotein B (ApoB), a valuable biomarker for cardiovascular diseases, in Korean adults who had undergone health check-ups and showed normal lipid levels under traditional lipid tests, including total cholesterol, triglyceride, and high-density lipoprotein cholesterol, along with ApoB. We compared the findings with different cutoffs for ApoB from international clinical guidelines. Among a total of 264,105 traditional lipid test sets, only 464 (0.2%) included ApoB tests, indicating underutilization of this test in health check-up clinics in Korea.

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Popovych, O. M., I. M. Budzulyak, O. V. Popovych, et al. "Synthesis and Electrochemical Properties of Nanocrystalline Nickel Molybdate." Physics and Chemistry of Solid State 22, no. 1 (2021): 123–31. http://dx.doi.org/10.15330/pcss.22.1.123-131.

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We have obtained nanocrystalline hydrate and alpha phase of nickel molybdate by a hydrothermal technique. On the basis of the obtained cyclic voltammetry data, we have evaluated the contribution of faradaic and non-faradaic processes to the total capacitance of molybdates under study. It was found that the specific capacitance of hydrate NiMoO4·H2O is 621 F/g at a scan rate of 1 mV / s and the specific capacitance of the α-NiMoO4 is 281 F/g. Cathodes for hybrid supercapacitors were formed on the basis of the obtained nickel molybdates. As a result of electrochemical studies, it was found that

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Marrero-Gonzalez, Alejandro R., Anna Crawford, Fitzgerald Draper, Andrea Incudine, Stacy Tessler Lindau, and Evan M. Graboyes. "Abstract 1016: Food insecurity among patients with cancer in the US." Cancer Research 84, no. 6_Supplement (2024): 1016. http://dx.doi.org/10.1158/1538-7445.am2024-1016.

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Abstract Introduction: Food insecurity (FI) is common among cancer patients and can lead to decreased treatment adherence, worse quality of life, and increased recurrence and mortality. Although some studies suggest that patients with cancer are particularly susceptible to FI, these studies have been limited by their small sample size, narrow sampling of cancer types and stages, and limited geographic scope. To address this gap, this study leverages data from a supportive care organization to characterize FI prevalence and associated risk factors in a nationwide sample of patients with diverse

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Mathioudakis, Nestoras Nicolas, Estelle Everett, Shuvodra Routh, et al. "Development and validation of a prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults." BMJ Open Diabetes Research & Care 6, no. 1 (2018): e000499. http://dx.doi.org/10.1136/bmjdrc-2017-000499.

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ObjectiveTo develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults.Research design and methodsWe collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <

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Hunter, Sandra K., Romuald Lepers, Carol J. MacGillis, and Roger M. Enoka. "Activation among the elbow flexor muscles differs when maintaining arm position during a fatiguing contraction." Journal of Applied Physiology 94, no. 6 (2003): 2439–47. http://dx.doi.org/10.1152/japplphysiol.01038.2002.

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Twenty-four men ( n = 11) and women ( n = 13) supported an inertial load equivalent to 20% of the maximum voluntary contraction force with the elbow flexor muscles for as long as possible while maintaining a constant elbow angle at 90°. Endurance time did not differ on the three occasions that the task was performed (320 ± 149 s; P > 0.05), and there was no difference between women (360 ± 168 s) and men (273 ± 108 s; P = 0.11). The rate of increase in average electromyogram (EMG) for the elbow flexor muscles was similar across sessions ( P > 0.05). However, average EMG during the fatigui

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Hassan, F. A., Сh Alali, and L. R. Gainullina. "Increasing the efficiency of wind farms." iPolytech Journal 26, no. 2 (2022): 217–27. http://dx.doi.org/10.21285/1814-3520-2022-2-217-227.

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This work evaluates variables affecting wind parameters in order to maximally reduce turbulence and trace. In addition, the position of each wind turbine in a farm and the limits of wind turbines are determined in order to determine an optimal distance between them. To this end, a 150 MW wind farm operating 60 wind turbines was studied. The speed and direction of wind was studied using a wind-measuring installation. An optimal mode of operating a wind farm was calculated using the WindFarmer software produced by DNV GL (Norway). Experiments conducted on a site in the south-east of the Republic

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Bizino, Maurice B., Ingrid M. Jazet, Paul de Heer, et al. "Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation." Diabetologia 63, no. 1 (2019): 65–74. http://dx.doi.org/10.1007/s00125-019-05021-6.

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Abstract Aims/hypothesis The aim of this work was to assess the effect of liraglutide on ectopic fat accumulation in individuals with type 2 diabetes mellitus. Methods This study is a pre-specified subanalysis of the MAGNetic resonance Assessment of VICTOza efficacy in the Regression of cardiovascular dysfunction In type 2 diAbetes mellitus (MAGNA VICTORIA) study, with primary endpoints being the effects of liraglutide on left ventricular diastolic and systolic function. The MAGNA VICTORIA study was a single-centre, parallel-group trial in 50 individuals with type 2 diabetes mellitus (BMI >

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