Journal articles: '37-41'

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Rehak, Katrin, Manfred R. Strecker, and Helmut P. Echtler. "Morphotectonic segmentation of an active forearc, 37°–41°S, Chile." Geomorphology 94, no. 1-2 (February 2008): 98–116. http://dx.doi.org/10.1016/j.geomorph.2007.05.002.

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Schroeter-Wittke, Harald. "Joh 12, 34-36(37-41) 20.1.2013 Letzter Sonntag nach Epiphanias." Göttinger Predigtmeditationen 67, no. 1 (November 2012): 99–104. http://dx.doi.org/10.13109/gpre.2012.67.1.99.

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SHIMBARA, Y., Y. FUJITA, T. ADACHI, G. P. A. BERG, B. A. BROWN, H. FUJIMURA, H. FUJITA, et al. "ISOSPIN SYMMETRY OF Tz = ±3/2 → ±1/2 GAMOW-TELLER TRANSITIONS IN A = 37 AND A = 41 NUCLEI." Modern Physics Letters A 25, no. 21n23 (July 30, 2010): 1976–79. http://dx.doi.org/10.1142/s0217732310000782.

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Under the assumption of good isospin symmetry, Tz = ±3/2 → ±1/2 Gamow-Teller (GT) transitions in a mass A isobar are analogous, where Tz is the z component of isospin T defined by 1/2(N - Z). We studied the Tz = +3/2 → +1/2 GT transitions by using the 37 Cl (3 He ,t)37 Ar and 41 K (3 He ,t)41 Ca reactions at E beam = 140 MeV / nucleon . The GT transition strengths in 37 Ar and 41 Ca were obtained up to the excitation energy (Ex) of 14.2 MeV and 10.4 MeV with energy resolutions of 30 and 35 keV, respectively. The obtained GT strengths were compared with those of the Tz = -2/3 → -1/2 mirror transitions, measured by the β-decay of 37 Ca and 41 Ti , respectively. It was found that the overall distributions of the mirror transitions were similar in both A = 37 and A = 41 systems. In A = 37 the differences seen at lower excitation energies are suggested to be the effect of the tensor interaction in the charge-exchange reaction. The differences seen at higher excitation energies are suggested to be the effect of the Coulomb interaction that can break the mirror symmetry of the strength distributions.

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Padilla, Jaime, Angel Luis García-Villalón, Nuria Fernández, Luis Monge, Bernardino Gómez, and Godofredo Diéguez. "Effects of hyperthermia on contraction and dilatation of rabbit femoral arteries." Journal of Applied Physiology 85, no. 6 (December 1, 1998): 2205–12. http://dx.doi.org/10.1152/jappl.1998.85.6.2205.

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To analyze the effect of hyperthermia on the vascular response, the isometric response of isolated rabbit femoral artery segments was recorded at 37°C and hyperthermia (41 and 44°C). Contraction to potassium (5 × 10−3-5 × 10−2 M) was significantly greater at 41 and 44 than at 37°C and increased by inhibition of nitric oxide (NO) synthesis with N ω-nitro-l-arginine (l-NNA; 10−4 M) or endothelium removal at 37°C but not at 41 or 44°C. Norepinephrine (10−9-10−4M) produced a concentration-dependent contraction greater at 41 or 44 than at 37°C and not modified by endothelium removal orl-NNA at either temperature. Phenylephrine (10−9-10−4M) produced a contraction increased by warming to 44°C but not to 41°C. The specific α2-adrenoceptor agonist BHT-920 produced a weak contraction, reduced by the α1-adrenoceptor antagonist prazosin (10−6 M) and increased at 44°C but not at 41°C. The concentration-dependent contraction to endothelin-1 (ET-1; 10−11-10−7M) was increased by warming to 41 and 44°C and by endothelium removal or l-NNA at 37°C but not at 41 or 44°C. Response to ET-1 was reduced by endothelin ETA-receptor antagonist BQ-123 (10−5 M) and ETB-receptor antagonist BQ-788 (10−5 M). In arteries precontracted with ET-1 (10−8-3 × 10−8 M), relaxation to sodium nitroprusside (10−8-10−4M) was increased at 41 and 44°C vs. at 37°C, but that of ACh (10−8-10−4M) or adenosine (10−8-10−4M) was not different at all temperatures studied. Relaxation to ACh, but not adenosine, was reduced similarly byl-NNA at all temperatures studied. These results suggest hyperthermia in muscular arteries may inhibit production of, and increase dilatation to, NO, resulting in unchanged relaxation to ACh and increased constriction to KCl and ET-1, and may increase constriction to stimulation of α1-adrenoceptors by NO-independent mechanisms.

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Rose, O., E. Blanco, S. M. Martinez, E. K. Sim, M. Castillo, B. Lozoff, Y. E. Vaucher, and S. Gahagan. "Developmental Scores at 1 Year With Increasing Gestational Age, 37-41 Weeks." PEDIATRICS 131, no. 5 (April 15, 2013): e1475-e1481. http://dx.doi.org/10.1542/peds.2012-3215.

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Kurrelvink, Claudia, and Frank Zeidler. "Letzter Sonntag nach Epiphanias - 20. 1. 2013 Johannes 12,34-36(37-41)." Homiletische Monatshefte 88, no. 3 (November 2012): 112–16. http://dx.doi.org/10.13109/homh.2012.88.3.112.

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Riera, Gregorio, Megan Galindo, and Mark Turrentine. "Platelet Counts in Uncomplicated Pregnancies at Term." American Journal of Perinatology 37, no. 06 (April 12, 2019): 621–25. http://dx.doi.org/10.1055/s-0039-1685447.

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Abstract Objective This study aimed to evaluate platelet counts at delivery in uncomplicated pregnancies between 37 and 41 weeks of gestation. Study Design Platelet counts in women 16 to 45 years of age from August 1, 2011, through May 15, 2018, with a singleton pregnancy that delivered from 370/7 to 416/7 weeks of gestation. Women with pregnancy-related complications, preexisting disorders, or on medications that could affect platelet counts were excluded. Results A total of 18,526 women had uncomplicated pregnancies with mean platelet count from 370/7 to 416/7 weeks of gestation of 220 × 109/L. The lower limit 95th percentile (2.5% quantile) was 120 × 109/L. Platelet counts decreased weekly from 37 to 41 weeks of gestation, becoming significant at 39 weeks of gestation and beyond, compared with 37 weeks (p < 0.01). Mean platelet counts: 225 × 109/L at 37 weeks, 223 × 109/L at 38 weeks, 219 × 109/L at 39 weeks, 218 × 109/L at 40 weeks, and 216 × 109/L at 41 weeks of gestation. Platelet counts of less than 150 × 109/L occurred in 9.7%. Conclusion Platelet counts in uncomplicated pregnancies decrease weekly from 37 to 41 weeks of gestation. This will be important to consider when serial platelet values are monitored for other indications.

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Bernabucci, Umberto, Loredana Basiricò, Patrizia Morera, Nicola Lacetera, Bruno Ronchi, and Alessandro Nardone. "Heat shock modulates adipokines expression in 3T3-L1 adipocytes." Journal of Molecular Endocrinology 42, no. 2 (November 7, 2008): 139–47. http://dx.doi.org/10.1677/jme-08-0068.

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Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Pparγ in 3T3-L1 adipocytes. Compared with 37 °C, adiponectin mRNA was higher at 39 °C, and lower at 41 °C. Leptin mRNA was higher when adipocytes were exposed to 41 °C compared with 37 and 39 °C. Secretion of adiponectin increased at 39 °C, and when cells were exposed to 41 °C it was not detectable. Leptin secretion increased significantly at 41 °C, compared with 37 and 39 °C. Hspa2 mRNA was increased at 39 °C, and the highest level was reached at 41 °C. Pparγ mRNA exhibited a substantial increase in a temperature-dependent manner. The study provides the first evidence of a possible direct effect of heat shock on adiponectin and leptin gene expression and secretion, and demonstrates that the expression of the two adipokines is differentially regulated at the temperatures tested.

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Bibby, Susan, Sumeet Reddy, Terrianne Cripps, Steve McKinstry, Mark Weatherall, Richard Beasley, and Janine Pilcher. "Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study." Pulmonary Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/7951272.

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Objectives. Delivery of warmed, humidified air via nasal high flow therapy could potentially reduce replication of temperature-sensitive viruses in the upper respiratory tract. This study investigates whether nasal high flow therapy is well tolerated by healthy adults at 37°C and 41°C.Methods. In this randomised, double-blind, controlled crossover pilot trial, nasal high flow therapy was used to deliver humidified air at 35 L/min, at either 37°C or 41°C, for three one-hour sessions of use over one day. The alternative was delivered at least 14 days later. Ten healthy, nonsmoking adults were asked, via questionnaire after each day’s use, whether they would use nasal high flow therapy while being unwell with a cold or flu if it was demonstrated to improve symptoms.Results. All participants completed both interventions. Eighty percent responded “yes” to future use of nasal high flow therapy, for both 37°C and 41°C. There was no significant change from baseline in saccharin times following either intervention or in the following morning.Conclusions. Delivering humidified air via nasal high flow therapy at both 37°C and 41°C is well tolerated by healthy adults. This supports investigation into the potential use of nasal high flow therapy as treatment in viral upper respiratory tract infections.Trial Registration. This trial is registered withACTRN12614000183684(tolerability study of nasal delivery of humidified & warmed air).

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Amiel–Tison, C., F. Maillard, F. Lebrun, G. Bréart, and E. Papiernik. "Neurological and physical maturation in normal growth singletons from 37 to 41 weeks' gestation." Early Human Development 54, no. 2 (March 1999): 145–56. http://dx.doi.org/10.1016/s0378-3782(98)00087-5.

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Schertzer, J. D., H. J. Green, and A. R. Tupling. "Thermal instability of rat muscle sarcoplasmic reticulum Ca2+-ATPase function." American Journal of Physiology-Endocrinology and Metabolism 283, no. 4 (October 1, 2002): E722—E728. http://dx.doi.org/10.1152/ajpendo.00204.2002.

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To examine the thermal instability and the role of sulfhydryl (SH) oxidation on sarcoplasmic reticulum (SR) Ca2+-ATPase function, crude homogenates were prepared from the white portion of the gastrocnemius (WG) adult rat muscles ( n = 9) and incubated in vitro for ≤60 min either at a normal resting body temperature (37°C) or at a temperature indicative of exercise-induced hyperthermia (41°C) with DTT and without DTT (CON). In general, treatment with DTT resulted in higher Ca2+-ATPase and Ca2+ uptake values (nmol · mg protein−1 · min−1, P < 0.05), an effect that was not specific to time of incubation. Incubations at 41°C resulted in lower ( P< 0.05) Ca2+ uptake rates (156 ± 18 and 35.9 ± 3.3) compared with 37°C (570 ± 54 and 364 ± 26) at 30 and 60 min, respectively. At 37°C, ryanodine (300 μM), which was used to block Ca2+ release from the calcium release channel, prevented the time-dependent decrease in Ca2+ uptake. A general inactivation ( P < 0.05) of maximal Ca2+-ATPase activity ( V max) in CON was observed with incubation time (0 > 30 > 60 min), with the effect being more pronounced ( P < 0.05) at 41°C compared with 37°C. The Hill slope, a measure of co-operativity, and the pCa50, the cytosolic Ca2+ concentration required for half-maximal activation of Ca2+-ATPase activity, decreased ( P < 0.05) at 41°C only. Treatment with DTT attenuated the alterations in enzyme kinetics. The increase in V max with the Ca2+ionophore A-23187 was less pronounced at 41°C compared with 37°C. It is concluded that exposure of homogenates to a temperature typically experienced in exercise results in a reduction in the coupling ratio, which is mediated primarily by lower Ca2+ uptake and occurs as a result of increases in membrane permeability to Ca2+. Moreover, the decreases in Ca2+-ATPase kinetics in WG with sustained heat stress result from SH oxidation.

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Hassan, Intisar Abdullah, Jeannine M. Durdik, Rath Satyajit, Zachary Renfro, and Harrison Blake. "Investigation on the role of temperature in macrophage responses." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 126.10. http://dx.doi.org/10.4049/jimmunol.202.supp.126.10.

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Abstract This study investigated temperature-associated changes in macrophage activation and metabolism across species. Macrophages were isolated from C57BL/6J mice, broiler chicken spleens, and rainbow trout head kidneys, treated with lipopolysaccharide (LPS) and nitric oxide (NO) responses measured. Mouse macrophage NO production was similar at 37°C (normal body temp.) and 35°C. However at 33°C and 28°C responses dropped notably. At 39°C, Mouse bone marrow-derived macrophages (BMDM) and mouse cell line, RAW264.7, showed higher NO production versus 37°C. In chicken splenic macrophages (CSM) LPS-induced NO responses were similar at 41°C (normal for avian) 37°C, and 39°C. A mild fever of 42°C had a large stimulatory effect on NO production compared to 41°C. During infection, trout induce fever by swimming to warmer water. We found NO responses in LPS-treated head kidney macrophages to be higher at 15, 28, and 37°C than at 4°C. Total protein synthesis was evaluated via fluorescence. Without LPS stimulation, peritoneal resident mouse macrophages (PRM) from young mice showed similar protein synthesis at 37°C and 39°C. In both young and aged LPS-stimulated PRM, significantly higher protein synthesis was observed at 39°C compared to 37°C, though the increase was smaller in aged PRM. However, this effect was not uniform across all tissues. LPS stimulated young (BMDM) showed an increased protein synthesis at 37°C but cells from aged did not. A further increase in LPS stimulation was observed at 39°C. Consistent with fever increasing protein synthesis, LPS-stimulated CSM and chicken cell line HTC, showed higher protein synthesis at 42°C compared with 41°C.

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Kirijackii, E. G. "РЕШЕНИЕ ОДНОЙ ЗАДАЧИ ИЗ ТЕОРИИ ИГР." Mathematical Modelling and Analysis 1, no. 1 (December 15, 1996): 37–41. http://dx.doi.org/10.3846/13926292.1996.9637048.

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Shu, Hong, and Fang Nie. "Clinical characteristics and prognosis of postpartum acute kidney injury." Journal of International Medical Research 49, no. 2 (February 2021): 030006052098838. http://dx.doi.org/10.1177/0300060520988388.

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Objective To investigate the clinical characteristics and prognoses of patients with postpartum acute kidney injury (PPAKI). Methods We retrospectively reviewed the clinical presentations, laboratory examinations, treatments, and outcomes of patients with PPAKI admitted to our hospital from January 2013 to December 2017. We then analyzed the clinical characteristics and prognoses of the mothers and their infants. Results Of 37 patients diagnosed with PPAKI, 26 (70.3%) received treatment in the intensive care unit, mainly for hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome (28/37, 75.7%), pre-eclampsia (26/37, 70.3%), and postpartum hemorrhage (22/37, 59.5%). Twenty patients required renal replacement treatment (RRT), but renal recovery times were similar in the RRT and non-RRT groups. Renal function recovered completely in 30 patients (81.1%) and partially in one patient (2.7%), and was not re-examined in two patients (5.4%). Three patients (8.1%) were lost to follow-up. Only one patient (2.7%) remained dialysis-dependent, and no maternal deaths occurred. The preterm birth, low birth weight, and infant survival rates were 70.7% (29/41), 68.3% (28/41), and 78.0% (32/41), respectively. Conclusion RRT does not reduce renal recovery time compared with non-RRT. Overall, the prognoses of both mothers and their fetuses are good following treatment for PPAKI.

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Camargo, Celina Raquel de Oliveira, and Carlos Eduardo de Oliveira Camargo. "Trigo: avaliação tecnológica de novas linhagens." Bragantia 46, no. 2 (1987): 169–81. http://dx.doi.org/10.1590/s0006-87051987000200002.

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Avaliou-se a qualidade tecnológica das linhagens de trigo IAC-22, IAC-31, IAC-37, IAC-41, IAC-46, IAC-57 e IAC-60, obtidas pelo programa de melhoramento do Instituto Agronômico, tomando como controle uma amostra de trigo norte-americano e amostras dos cultivares Alondra-S-46 e IAC-18, comerciais no Estado de São Paulo. Os maiores teores de proteína foram encontrados no 'IAC-22' e nas linhagens IAC-37 e IAC-41, superiores àqueles das farinhas de trigo importado, Alondra-S-46 e IAC-18. Todas as farinhas de trigo apresentaram viscosidade máxima superior a 1.000 unidades amilográficas, indicando a ausência da enzima alfa-amilase. As farinhas de trigo importado e das linhagens IAC-31, IAC-41 e IAC-57 apresentaram características farinográficas típicas de farinha de força média a forte e IAC-18 e IAC-60, de farinha média a fraca. Os extensigramas mostraram que as linhagens IAC-41, IAC-31, IAC-57 e IAC-46 apresentaram glúten com características viscoelásticas adequadas para a produção de pão. Pelo teste de panificação, concluiu-se que as linhagens IAC-31 e IAC-41 produziram pão de qualidade "muito boa", semelhante à da farinha de trigo importado; IAC-57, IAC-37 e IAC-60, pão de qualidade "boa" e similar à do 'Alondra-S-46'; as linhagens IAC-46 e IAC-22 tiveram o pior comportamento em relação à qualidade de pão, "regular", semelhante à do 'IAC-18'.

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Kviadaras, B. "СИЛЬНО ВЫРОЖДАЮЩЕЙСЯ ЭЛЛИПТИЧЕСКИЕ УРАВНЕНИЯ В КОМПЛЕКСНОЙ ОБЛАСТИ." Mathematical Modelling and Analysis 1, no. 1 (December 15, 1996): 49–50. http://dx.doi.org/10.3846/13926292.1996.9637052.

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Zeng, Rong, Min Li, Qing Chen, Le Wang, Ping Zhan, Chong Wang, Guixia Lv, Yongnian Shen, and Weida Liu. "In VitroAnalyses of Mild Heat Stress in Combination with Antifungal Agents against Aspergillus fumigatus Biofilm." Antimicrobial Agents and Chemotherapy 58, no. 3 (December 16, 2013): 1443–50. http://dx.doi.org/10.1128/aac.01007-13.

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ABSTRACTAspergillus fumigatusbiofilms still present a challenge for effective treatment in clinical settings. While mild heat stress has been introduced as a treatment for infectious diseases, the effectiveness of mild heat stress onA. fumigatusbiofilm formation and antifungal susceptibility is still unknown. In the present study, confocal laser scanning microscopy (CLSM) was used to image and quantifyAspergillus fumigatusbiofilm formation under three different regimens of continuous mild heat stress: at 37, 39, and 41°C. Furthermore, fungal growth has been investigated under the above conditions in combination with antifungal drugs (amphotericin B [AMB], micafungin [MCF], and voriconazole [VOC]) at early and late stages. CLSM analysis showed that higher temperatures induce earlier germination and greater hyphal elongation but poorer polar growth and reduced biofilm thickness. In the early stage of biofilm formation, the combination of treatment at 39 or 41°C with MCF or VOC produced no visible difference in biomass formation from similar treatments at 37°C with the same drug. Interestingly, AMB treatment at 37°C inhibited early stage biofilm formation to a much greater extent than at 39 and 41°C. At the late stage of biofilm formation, the mild heat treatments at 39 and 41°C with AMB, MCF, and VOC inhibited biomass formation compared to that at 37°C. The present data show that mild heat stress has a negative regulatory effect on biofilm formationin vitro, and antifungal drug improvement with mild heat treatment at late-stage biofilm formation provides useful indications of possible effective strategies for clinical management of aspergillosis.

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Kleiza, I. "ВЫЧИСЛЕНИЕ ИНТЕГРАЛА, СВЯЗАННОГО С ИССЛЕДОВАНИЕМ ЭЛЕКТРОПРОВОДНОСТИ АНИЗОТРОПНО ПРОВОДЯЩИХ СРЕД." Mathematical Modelling and Analysis 1, no. 1 (December 15, 1996): 47–48. http://dx.doi.org/10.3846/13926292.1996.9637051.

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Luo, Robert F., Cheyenne Curry, Nathan Taylor, Indre Budvytiene, and Niaz Banaei. "Rapid Detection of Acquired and Inducible Clarithromycin Resistance in Mycobacterium abscessus Group by a Simple Real-Time PCR Assay." Journal of Clinical Microbiology 53, no. 7 (April 22, 2015): 2337–39. http://dx.doi.org/10.1128/jcm.00132-15.

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By targeting theerm(41) andrrlgenes in theMycobacterium abscessusgroup, a multiplex real-time PCR assay for clarithromycin resistance showed 95% (38/40) concordance with nucleic acid testing and 95% (37/39) concordance with phenotypic testing. This assay provides a simple and rapid alternative to extended incubation orerm(41) sequencing.

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Blasiak, Janusz, Kinga Widera, and Tomasz Pertyński. "Hyperthermia can differentially modulate the repair of doxorubicin-damaged DNA in normal and cancer cells." Acta Biochimica Polonica 50, no. 1 (March 31, 2003): 191–95. http://dx.doi.org/10.18388/abp.2003_3726.

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Hyperthermia can modulate the action of many anticancer drugs, and DNA repair processes are temperature-dependent, but the character of this dependence in cancer and normal cells is largely unknown. This subject seems to be worth studying, because hyperthermia can assist cancer therapy. A 1-h incubation at 37 degrees C of normal human peripheral blood lymphocytes and human myelogenous leukemia cell line K562 with 0.5 microM doxorubicin gave significant level of DNA damage as assessed by the alkaline comet assay. The cells were then incubated in doxorubicin-free repair medium at 37 degrees C or 41 degrees C. The lymphocytes incubated at 37 degrees C needed about 60 min to remove completely the damage to their DNA, whereas at 41 degrees C the time required for complete repair was shortened to 30 min. There was also a difference between the repair kinetics at 37 degrees C and 41 degrees C in cancer cells. Moreover, the kinetics were different in doxorubicin-sensitive and resistant cells. Therefore, hyperthermia may significantly affect the kinetics of DNA repair in drug-treated cells, but the magnitude of the effect may be different in normal and cancer cells. These features may be exploited in cancer chemotherapy to increase the effectiveness of the treatment and reduce unwanted effects of anticancer drugs in normal cells and fight DNA repair-based drug resistance of cancer cells.

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Blitzer, David, Asma S. Habib, John W. Brown, Adam C. Kean, Jiuann-Huey I. Lin, Mark W. Turrentine, Mark D. Rodefeld, Jeremy L. Herrmann, and William Aaron Kay. "Early conversion of classic Fontan conversion may decrease term morbidity: single centre outcomes." Cardiology in the Young 29, no. 8 (June 28, 2019): 1045–50. http://dx.doi.org/10.1017/s104795111900146x.

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AbstractBackground:The initial classic Fontan utilising a direct right atrial appendage to pulmonary artery anastomosis led to numerous complications. Adults with such complications may benefit from conversion to a total cavo-pulmonary connection, the current standard palliation for children with univentricular hearts.Methods:A single institution, retrospective chart review was conducted for all Fontan conversion procedures performed from July, 1999 through January, 2017. Variables analysed included age, sex, reason for Fontan conversion, age at Fontan conversion, and early mortality or heart transplant within 1 year after Fontan conversion.Results:A total of 41 Fontan conversion patients were identified. Average age at Fontan conversion was 24.5 ± 9.2 years. Dominant left ventricular physiology was present in 37/41 (90.2%) patients. Right-sided heart failure occurred in 39/41 (95.1%) patients and right atrial dilation was present in 33/41 (80.5%) patients. The most common causes for Fontan conversion included atrial arrhythmia in 37/41 (90.2%), NYHA class II HF or greater in 31/41 (75.6%), ventricular dysfunction in 23/41 (56.1%), and cirrhosis or fibrosis in 7/41 (17.1%) patients. Median post-surgical follow-up was 6.2 ± 4.9 years. Survival rates at 30 days, 1 year, and greater than 1-year post-Fontan conversion were 95.1, 92.7, and 87.8%, respectively. Two patients underwent heart transplant: the first within 1 year of Fontan conversion for heart failure and the second at 5.3 years for liver failure.Conclusions:Fontan conversion should be considered early when atrial arrhythmias become common rather than waiting for severe heart failure to ensue, and Fontan conversion can be accomplished with an acceptable risk profile.

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Monzon, Michael A., Lauren M. Weidner, Travis W. Rusch, Selen Nehrozoglu, and George Hamilton. "High Temperature Limits of Survival and Oviposition of Phormia regina (Meigen) and Lucilia sericata (Meigen)." Insects 13, no. 11 (October 28, 2022): 991. http://dx.doi.org/10.3390/insects13110991.

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The temperature dependent development rates of blow flies allow blow flies to be used as biological clocks in forensic death investigations. However, the upper thermal limits of adult survival and oviposition, both required for producing larvae, remains largely unknown. Therefore, in this study we examined the impact of a range of temperatures between 37 °C and 44 °C on the likelihood of survival and egg-laying behavior of two species of medicolegal forensic importance, Lucilia sericata (Meigen) and Phormia regina (Meigen) (Diptera: Calliphoridae). To quantify the upper temperature limits of survival, adult fly colonies were exposed to 37 °C, 41 °C, 42 °C, 43 °C, and 44 °C for 24 h. Similarly for oviposition trials, adults of both species were exposed to 40 °C, 42 °C, and 43 °C with P. regina oviposition also observed at 41 °C. Trials lasted for 24 h with oviposition substrate replenished at the 12 h mark. A yes/no determination on egg deposition was made, eggs were counted, and a yes/no determination was made on egg hatch. Survival did not differ by species (p = 0.096). Overall, survival decreased with increasing temperatures, with ~100% at 37 °C, ~50% at 41 °C, ~37% at 42 °C, ~15% at 43 °C and 0% at 44 °C. Lucilia sericata laid eggs capable of hatch up to 43 °C, while Phormia regina egg-hatch was observed up to 41 °C. These results indicate a greater thermal tolerance of adult survival than for egg deposition and successful egg hatch, which supports previous experiments indicating blow flies stop laying eggs at sub-lethal temperatures. Furthermore, these data indicate that adult blow flies may find remains at or near time of death but may delay egg deposition until temperatures drop below an acceptable threshold.

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FRICK, Wendelin, Andrea BAUER, Jochen BAUER, Susanne WIED, and Günter MÜLLER. "Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes." Biochemical Journal 336, no. 1 (November 15, 1998): 163–81. http://dx.doi.org/10.1042/bj3360163.

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A set of synthetic phosphoinositolglycan (PIG) compounds has been demonstrated to exert insulin-mimetic activity on glucose and lipid metabolism in rat adipocytes differing considerably in potency [compound 41 > 37 > 45 ≫ 7 > 1; W. Frick, A. Bauer, J. Bauer, S. Wied and G. Müller, G. (1998) Biochemistry 37, 13421–13436]. In the present study we examine whether these differences are based on the capability of the PIG compounds to stimulate signalling components which are thought to mediate metabolic insulin action. Studies using a tyrosine kinase inhibitor and introduction into adipocytes of anti-phosphotyrosine or inhibitory anti-insulin receptor β-subunit antibodies demonstrated dependence on tyrosine phosphorylation but independence of insulin receptor kinase activation of the insulin-mimetic signalling and metabolic activity of the PIG compounds. The five compounds elicited in rat adipocytes a significant increase in tyrosine phosphorylation of both insulin receptor substrate 1 (IRS-1) and IRS-3 and, to a minor degree, IRS-2, in IRS-1/3-associated phosphatidylinositol 3-kinase (PI 3-K) protein as well as activity, and in protein kinase B (PKB) activity as well as phosphorylation. This was most pronounced for compound 41, approaching 65–95% of the maximal insulin response (MIR) at 20 µM, and declined in the order of compounds 37, 45, 7 and 1. The same ranking was true for the maximal inhibition of glycogen synthase kinase 3 activity (GSK-3) (41, 75% of MIR; compound 37, 65%; compound 7, 25%; compound 1, 10%) and GSK-3 autophosphorylation. The half-maximal concentrations effective for signalling (compound 41, 2–5 µM; compound 37, 10–20 µM) corresponded well to those stimulating glucose and lipid metabolism. Interestingly, compounds 37 and 41 stimulated mitogen-activated protein kinase (MAPK) and protein synthesis in rat adipocytes to only about 20–30% (at 50 µM) of MIR. We conclude that in rat adipocytes: (i) the potency of PIG compounds to regulate glucose/lipid metabolism depends on the activation of PI 3-K and PKB and inhibition of GSK-3; (ii) initiation of tyrosine phosphorylation of IRS-1/3 is sufficient and activation of the PI 3-K cascade is required for insulin-mimetic metabolic signalling; and (iii) PIG compounds are quite selective for the PI 3-K compared to the MAPK cascade, (iv) PIG compounds seem to use the same signalling components downstream of PI 3-K (including Rab4) for stimulation of glucose transport as does insulin. Thus the early signalling step(s) used by PIG, but not by insulin, may represent a target for the treatment of insulin-resistant states.

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Daniel, O'Kennedy F. "Perspectives on mission in the book of Zechariah." Missionalia 41, no. 3 (December 1, 2014): 223. http://dx.doi.org/10.7832/41-3-37.

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ZHMURKO, Irina M. "Financial and Legal Prospects for the Use of Government Bond Loans in Modern Conditions." Journal of Advanced Research in Law and Economics 10, no. 3 (June 30, 2019): 971. http://dx.doi.org/10.14505//jarle.v10.3(41).37.

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The purpose of the study is to identify positive aspects of expanding the use of government bond loans. The paper also focuses on theoretical concepts of the ratio of taxes and loans, analyzing the advantages and disadvantages of government bond loans to determine their impact on the decisions of the issuer and the investor. Consideration of foreign experience in the use of bond loans allows identifying common features and aspects to improve the legal regulation of this institution in Russia science and practice. The results of the research consist of summarizing the studied material and describing the prospects for the development and use of government loans as a tool of financial and legal policy. The experience of foreign countries proves that it is possible to determine the legal nature of a government bond loan through the prism of regulating a new institution – the issue obligation. Conclusion: it is advisable to adopt a normative legal act that would systematize the form of government debt, contain general rules for the use of certain types of borrowing and mechanisms for servicing and repayment of debt, and provide other guarantees, principles of compensation, ways to restructure debt obligations, as well as a mechanism for interaction of public authorities in this area with clear regulation of the powers of public authorities and sanctions for late performance or non-performance by the issuer of its obligations.

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TAYLOR, L. H., F. KATZER, B. R. SHIELS, and S. C. WELBURN. "Genetic and phenotypic analysis of Tunisian Theileria annulata clones." Parasitology 126, no. 3 (March 2003): 241–52. http://dx.doi.org/10.1017/s0031182002002810.

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Many parasite species are known to show high levels of genetic diversity, yet the consequences of this diversity for host–parasite interactions are not well understood. Variation in phenotypic traits such as growth rates and the ability to form transmission stages are raw material for natural and artificial selection to act upon with consequences for the evolution of the parasite species and disease control. In order to study genetic and phenotypic diversity amongst Theileria annulata parasites, a collection of 52 parasite clones was generated from cattle isolates and tick material recently collected in Tunisia. Genetic diversity was assessed using PCR-RFLP and monoclonal antibody markers, and genetically distinct clones selected for further study. Clones varied significantly in their growth rates in culture at 37 °C, their viability after a period of culture at 41 °C and their differentiation rates into transmission stages after culturing at 41 °C. The viability of a clone after culturing at 41 °C could not be predicted from its growth rate at 37 °C, but across clones, differentiation rates were positively correlated with growth rates at 37 °C. All 3 in vitro measures are likely to have relevance to parasite–host interactions in animals with clinical theileriosis, and should be acted on by within-host and between-host selection.

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Talukder, MAH, MS Rahman, Z. Haque, KK Barman, and UK Laily. "Dissemination of BARI released potato varieties in Rangpur region of Bangladesh." Progressive Agriculture 32, no. 1 (September 20, 2021): 17–21. http://dx.doi.org/10.3329/pa.v32i1.55711.

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The experiment was conducted during rabi season 2019-2020 at Rangpur and Kurigram districts under Agricultural Research Station, On Farm Research Division, Alamnagar, Rangpur to promote and disseminate newly released potato variety, BARI Alu-35, BARI Alu-36, BARI Alu-37, BARI Alu-40 and BARI Alu-41among the potato growers of Rangpur sadar Upzilla in Rangpur and Chilmari Upazilla in Kurigram. The experiment was arranged in a randomized complete block design (RCBD) with four dispersed replications. The treatments included T1: BARI Alu-35, T2: BARI Alu-36, T3: BARI Alu-37, T4: BARI Alu-40 and T5: BARI Alu-41. BARI Alu-41 showed excellent performance and higher yield followed by BARI Alu-40 and BARI Alu-36. Farmers were happy to observe the performance of the varieties and demanded quality seed for next year cultivation. The highest common scab infection was observed in (BARI Alu-35) (1.62%) where the lowest in BARI Alu-41. Maximum virus infected was found in BARI Alu-40 (2.29%), where the lowest infection was observed in BARI Alu-41 (1.22%). Progressive Agriculture 32 (1): 17-21, 2021

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Inaba, Hidefumi, Leonard Moise, William Martin, Anne S. De Groot, Joe Desrosiers, Ryan Tassone, George Buchman, Takashi Akamizu, and Leslie J. De Groot. "Epitope Recognition in HLA-DR3 Transgenic Mice Immunized to TSH-R Protein or Peptides." Endocrinology 154, no. 6 (April 16, 2013): 2234–43. http://dx.doi.org/10.1210/en.2013-1033.

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Abstract Development of Graves' disease is related to HLA-DR3. The extracellular domain (ECD) of human TSH receptor (hTSH-R) is a crucial antigen in Graves' disease. hTSH-R peptide 37 (amino acids 78–94) is an important immunogenic peptide in DR3 transgenic mice immunized to hTSH-R. This study examined the epitope recognition in DR3 transgenic mice immunized to hTSH-R protein and evaluated the ability of a mutant hTSH-R peptide to attenuate the immunogenicity of hTSH-R peptide 37. DR3 transgenic mice were immunized to recombinant hTSH-R-ECD protein or peptides. A mutant hTSH-R 37 peptide (ISRIYVSIDATLSQLES: 37m), in which DR3 binding motif position 5 was mutated V>A, and position 8 Q>S, was synthesized. 37m should bind to HLA-DR3 but not bind T cell receptors. DR3 transgenic mice were immunized to hTSH-R 37 and 37m. Mice immunized to hTSH-R-ECD protein developed strong anti-hTSH-R antibody, and antisera reacted strongly with hTSH-R peptides 1–5 (20–94), 21 (258–277), 41 (283–297), 36 (376–389), and 31 (399–418). Strikingly, antisera raised to hTSH-R peptide 37 bound to hTSH-R peptides 1–7 (20–112), 10 (132–50), 33 (137–150), 41, 23 (286–305), 24 (301–320), 36, and 31 as well as to hTSH-R-ECD protein. Both antibody titers to hTSH-R 37 and reaction of splenocytes to hTSH-R 37 were significantly reduced in mice immunized to hTSH-R 37 plus 37m, compared with mice immunized to hTSH-R 37 alone. The ability of immunization to a single peptide to induce antibodies that bind hTSH-R-ECD protein, and multiple unrelated peptides, is a unique observation. Immunogenic reaction to hTSH-R peptide 37 was partially suppressed by 37m, and this may contribute to immunotherapy of autoimmune thyroid disease.

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Hua, Jing, Jie Sun, Zhijuan Cao, Xiaotian Dai, Senran Lin, Jialin Guo, Guixiong Gu, and Wenchong Du. "Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China." BMJ Open 9, no. 4 (April 2019): e025275. http://dx.doi.org/10.1136/bmjopen-2018-025275.

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ObjectivesThis study aimed to explore the cognitive development of low-risk children during early childhood for early-term births at 37 and 38 weeks of gestation compared with full term births at 39–41 weeks of gestation.Setting and participantsWe conducted a cross-sectional study in Shanghai, one of the largest cities in China. A total of 1444 children from singleton pregnancies born at term gestation were included in the study.MeasuresThe cognitive outcomes of the subjects were measured using the cognitive subtest of Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) across three cities in China. We analysed the association between gestational age and cognitive development during infancy and toddler stages using multivariate linear modelling.ResultsThe cognitive development scores for infants born at 37 gestational weeks were significantly lower than those born at 39–41 gestational weeks (β=−2.257, 95% CI −4.280 to −0.235; p<0.05) after adjusting for children’s and maternal characteristics, as well as socio-economic factors. However, there were no significant differences in cognitive ability between infants born at 38 gestational weeks compared with their full-term counterparts (p>0.05). Moreover, these effects were not found in toddlers (between 17 and 48 months of age) after adjusting for the possible confounders (p>0.05).ConclusionsInfants born at 37 weeks of gestation exhibited weaker cognitive ability compared with those born at 39–41 weeks of gestation. Our findings provide evidences for the close monitoring of potential developmental problems in early-term children, especially those born at 37 gestational weeks.

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Åmark, Hanna, Christina Pilo, and Ingela Hulthén Varli. "Stillbirth in term and late term gestations in Stockholm during a 20-year period, incidence and causes." PLOS ONE 16, no. 5 (May 25, 2021): e0251965. http://dx.doi.org/10.1371/journal.pone.0251965.

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Introduction The incidence of stillbirth has decreased marginally or remained stable during the past decades in high income countries. A recent report has shown Stockholm to have a lower incidence of stillbirth at term than other parts of Sweden. The risk of antepartum stillbirth increases in late term and postterm pregnancies which is one of the factors contributing to the current discussion regarding the optimal time of induction of labor due to postterm pregnancy. Material and methods This is a cohort study based on the Stockholm Stillbirth Database which contains all cases of stillbirth from 1998-2018 in Stockholm County. All cases were reviewed systematically and the cause of death was evaluated according to the Stockholm Stillbirth Classification. Stillbirths diagnosed between gestational week (GW) 37+0 and 40+6 n = 605 were compared to stillbirths diagnosed from GW 41+0 and onwards n = 157, according to the cause of stillbirth and pregnancy and maternal characteristics. The aim was to evaluate the incidence of stillbirth over time and the incidence of stillbirth diagnosed from GW 41+0. Results In Stockholm County the overall incidence of stillbirth has decreased from 4.6/1000 births during the period 1998-2004 to 3.4/1000 births during the period 2014-2018, p-value <0.001. When comparing the same time periods, the incidence of stillbirth diagnosed from GW 41+0 and onwards has decreased from 0.5/1000 births to 0.15/1000 births, p-value <0.001. Among women still pregnant at GW 41+0 the incidence of stillbirth has decreased from 1.8/ 1000 to 0.5/ 1000. When comparing stillbirths diagnosed at GW 37+0-40+6 with stillbirths diagnosed from GW 41+0 and onwards infection was a more common cause of stillbirth in the latter group. Conclusion In Stockholm County there was a decreasing incidence of stillbirth overall and in stillbirths diagnosed from 41+0 weeks of gestation and onwards during the period 1998-2018. In stillbirths diagnosed from GW 41+0 and onwards infection was a more common cause of death compared to stillbirths diagnosed between GW 37+0 and 40+6.

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Bicocca, Matthew J., Megha Gupta, Stephen M. Wagner, Hector Mendez-Figueroa, and Suneet P. Chauhan. "Adverse maternal and neonatal outcomes among low-risk women with obesity at 37-41 weeks gestation." European Journal of Obstetrics & Gynecology and Reproductive Biology 254 (November 2020): 141–46. http://dx.doi.org/10.1016/j.ejogrb.2020.08.053.

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Vanhoutte, P. M., J. P. Cooke, L. E. Lindblad, J. T. Shepherd, and N. A. Flavahan. "Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature." Clinical Science 68, s10 (January 1, 1985): 121s—123s. http://dx.doi.org/10.1042/cs068s121.

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1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37°-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.

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Gerlofs-Nijland, Miriam E., Karel J. M. Assmann, Henry B. P. M. Dijkman, Jürgen W. C. Dieker, Jacco P. H. F. van Son, Stef Mentzel, Jorge P. van Kats, et al. "Albuminuria in Mice after Injection of Antibodies against Aminopeptidase A: Role of Angiotensin II." Journal of the American Society of Nephrology 12, no. 12 (December 2001): 2711–20. http://dx.doi.org/10.1681/asn.v12122711.

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ABSTRACT. It has been shown that injection of combinations of anti-aminopeptidase A (APA) monoclonal antibodies (mAb) that inhibit the enzyme activity induces an acute albuminuria in mice. This albuminuria is not dependent on inflammatory cells, complement, or the coagulation system. APA is an important regulator of the renin-angiotensin system because it is involved in the degradation of angiotensin II (Ang II). This study examined the potential role of glomerular Ang II in the induction of albuminuria. The relation among renal Ang II, glomerular APAX enzyme activity, and albuminuria was examined first. Injection of the nephritogenic combinations ASD-3/37 and ASD-37/41 in BALB/c mice induced albuminuria, whereas the non-nephritogenic combination ASD-3/41 had no effect. There was no clear relation between the inhibition of glomerular APA activity and albuminuria, yet it was evident that intrarenal Ang II levels were significantly increased in albuminuric mice and not in nonalbuminuric mice. As a next step, anti-APA mAb were administered to angiotensinogen-deficient mice that do not produce Ang II, and kidney morphology and albuminuria were determined. Angiotensinogen-deficient mice also developed albuminuria upon ASD-37/41 administration. Altogether, these findings clearly demonstrate that Ang II is not required for the induction of albuminuria upon injection of enzyme-inhibiting anti-APA mAb.

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Kroth, Jerry, Marylynne Garcia, Michelle Hallgren, Emilyann LeGrue, Maureen Ross, and Juliana Scalise. "Perinatal Loss, Trauma, and Dream Reports." Psychological Reports 94, no. 3 (June 2004): 877–82. http://dx.doi.org/10.2466/pr0.94.3.877-882.

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This study investigated correlations among dream characteristics and measures of trauma and perinatal bereavement as reported by women who have experienced perinatal loss. 37 women who had experienced perinatal loss were randomly selected from a perinatal support group and administered the Impact of Event Scale, the Perinatal Grief Scale, and the KJP Dream Inventory. Scores on the Impact of Events Scale (IES) correlated with Emotional Pain (.41), Despair (.37), Dreams of Death (.31), Dreams of Water (–.29), and Dreams of Being Famous (–.36). Subjects who reported higher Social Support and Emotional Expressiveness throughout their trauma showed lower scores on IES Total scores (–.52), Despair (–.62), and reported dreaming more in color (.41). Results are discussed in terms of the hypothesized role dreams may play in the grief-recovery process.

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Meng, Zong-Da, Margery L. Kennett, Suzanne M. Rodger, Kaye E. Dickson, Bruce N. Anderson, and Ian D. Gust. "Further characterization of 41 isolates of adenovirus types 19/37 by serum neutralization and DNA restriction enzyme analysis." Journal of Hygiene 97, no. 2 (October 1986): 377–83. http://dx.doi.org/10.1017/s0022172400065463.

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SummaryForty-one strains of adenovirus type 19/37 (Ad19/37) mainly isolatedI from patients with keratoconjunetivitis or conjunctive between 1974 and 1984 were re-evaluated by serum neutralization (SN), haemagglutination inhibition (HI) and DNA restriction analysis. Of 19 isolates which were neutralized to high titre by antiserum prepared against prototype Ad19, 5 showed cross-reactivity with 32–64 units of Ad37 antiserum, while of 22 strains neutralizedto high titre by Ad37 antiserum, 3 showed eross-reaetivity with 32 units of Ad19 antiserum By DNA restriction analysis, all Ad19 isolates were identieal to each other and to Ad19A virus. Using endonuclease Bgl 1, three variants were observed among the Ad37 isolates.

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Dokladny, Karol, Pope L. Moseley, and Thomas Y. Ma. "Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability." American Journal of Physiology-Gastrointestinal and Liver Physiology 290, no. 2 (February 2006): G204—G212. http://dx.doi.org/10.1152/ajpgi.00401.2005.

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The effects of physiologically relevant increase in temperature (37–41°C) on intestinal epithelial tight junction (TJ) barrier have not been previously studied. Additionally, the role of heat-shock proteins (HSPs) in the regulation of intestinal TJ barrier during heat stress remains unknown. Because heat-induced disturbance of intestinal TJ barrier could lead to endotoxemia and bacterial translocation during physiological thermal stress, the purpose of this study was to investigate the effects of modest, physiologically relevant increases in temperature (37–41°C) on intestinal epithelial TJ barrier and to examine the protective role of HSPs on intestinal TJ barrier. Filter-grown Caco-2 intestinal epithelial cells were used as an in vitro intestinal epithelial model system to assess the effects of heat exposure on intestinal TJ barrier. Exposure of filter-grown Caco-2 monolayers to modest increases in temperatures (37–41°C) resulted in a significant time- and temperature-dependent increases in Caco-2 TJ permeability. Exposure to modest heat (39 or 41°C) resulted in rapid and sustained increases in HSP expression; and inhibition of HSP expression produced a marked increase in heat-induced increase in Caco-2 TJ permeability ( P < 0.001). Heat exposure (41°C) resulted in a compensatory increase in Caco-2 occludin protein expression and an increase in junctional localization. Inhibition of HSP expression prevented the compensatory upregulation of occludin protein expression and produced a marked disruption in junctional localization of occludin protein during heat stress. In conclusion, our findings demonstrate for the first time that a modest, physiologically relevant increase in temperature causes an increase in intestinal epithelial TJ permeability. Our data also show that HSPs play an important protective role in preventing the heat-induced disruption of intestinal TJ barrier and suggest that HSP mediated upregulation of occludin expression may be an important mechanism involved in the maintenance of intestinal epithelial TJ barrier function during heat stress.

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Uehara, Patrícia Moreira, Rivaldo Venâncio da Cunha, Gracy Regina Oliveira L. Pereira, and Priscilla Alexandrino de Oliveira. "Envolvimento hepático em pacientes com dengue hemorrágico: manifestação rara?" Revista da Sociedade Brasileira de Medicina Tropical 39, no. 6 (December 2006): 544–47. http://dx.doi.org/10.1590/s0037-86822006000600006.

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As manifestações hepáticas são descritas como não usuais no dengue e podem evoluir com quadros graves e potencialmente letais. Avaliamos as alterações hepáticas em 41 pacientes com dengue hemorrágico com confirmação laboratorial (ELISA IgM positivo) em Campo Grande, Mato Grosso do Sul, Brasil e observamos 61% (25/41) de alteração na alanina aminotransferase e 80,5% (33/41) na aspartato aminotransferase, sendo que não houve diferenças estatisticamente significativas quando comparamos as várias formas clínicas. A variação nos valores de ALT foi de 14-547U/l, nos valores da AST foi de 11-298U/l. Náuseas e/ou vômitos foram referidos por 90% (37/41) dos pacientes, 46,3% (19/41) referiram dor abdominal e 10% (3/29) apresentavam hepatomegalia ao exame físico. A idade variou de 18 a 88 anos, 23 (56%) eram mulheres e 18 (44%) homens.

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MARSHALL, KRISTIN M., LOUIS NOWACZYK, TRAVIS R. MORRISSEY, VIVIANA LOEZA, LINDSAY A. HALIK, GUY E. SKINNER, N. RUKMA REDDY, GREGORY J. FLEISCHMAN, and JOHN W. LARKIN. "Effect of Sporulation Temperature on the Resistance of Clostridium botulinum Type A Spores to Thermal and High Pressure Processing." Journal of Food Protection 78, no. 1 (January 1, 2015): 146–50. http://dx.doi.org/10.4315/0362-028x.jfp-14-186.

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The purpose of this study was to determine the effect of sporulation temperature on the resistance of Clostridium botulinum type A spores of strains 62A and GiorgioA to thermal and high pressure processing (HPP). Spore crops produced in Trypticase–peptone–glucose–yeast extract broth at four incubation temperatures (20, 27, 37, and 41°C) were harvested, and heat resistance studies were conducted at 105°C (strain 62A) and 100°C (strain GiorgioA). Resistance to HPP was evaluated by subjecting the spores to a high pressure (700 MPa) and temperature combination (105°C, strain 62A; 100°C strain GiorgioA) in a laboratory-scale pressure test system. The decimal reduction time (D-value) was calculated using the log-linear model. Although the time to sporulation for GiorgioA was shorter and resulted in higher spore concentrations than for 62A at 20, 27, and 37°C, GiorgioA did not produce a sufficient spore crop at 41°C to be evaluated. The heat resistance of 62A spores was greatest when produced at 27°C and decreased for spore crops produced above or below 27°C (D105°C-values: 20°C, 1.9 min; 27°C, 4.03 min; 37°C, 3.66 min; and 41°C, 3.5 min; P < 0.05). Unlike 62A, the heat resistance behavior of GiorgioA spores increased with rising sporulation temperature, and spores formed at the organism's optimum growth temperature of 37°C were the most resistant (D100°C-values: 20°C, 3.4 min; 27°C, 5.08 min; and 37°C, 5.65 min; P < 0.05). Overall, all spore crops were less resistant to pressure-assisted thermal processing than thermal treatment alone. Sporulation temperature has an effect on the resistance of C. botulinum spores to heat and HPP, and is characteristic to a particular strain. Knowledge of the effect of sporulation temperature on the resistance of C. botulinum spores is vital for the production of spores utilized in thermal and high pressure inactivation studies.

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Hassan, Intisar A., Zachary Renfro, Harrison Blake, Satyajit Rath, and Jeannine M. Durdik. "Effect of temperature on functional activity of macrophages in three different species." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 149.17. http://dx.doi.org/10.4049/jimmunol.204.supp.149.17.

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Abstract Temperature affects body physiological functions, including immunity in ways that influence survival. This study investigated the effect of temperature on macrophage activation and metabolism across species. Macrophages were isolated from mice, chicken or rainbow trout primary tissue or from macrophage cell lines and were activated with lipopolysaccharide (LPS) or IFN-γ. For mice, both Raw264.7 and primary cells, nitric oxide (NO) production was similar at 35°C and 37°C but dropped dramatically at temperatures below 35°C. At fever temperature (39°C), NO release increased in response to LPS. Young bone marrow derived macrophage (BMDM) and peritoneal resident macrophage (PRM) showed increased protein synthesis at 39°C compared to 37°C. Chicken splenic macrophages (CSM) showed NO responses that were similar at 37, 39, and at 41°C (normal for avian). A fever of 42°C had a large stimulatory effect on NO production compared to 41°C. A chicken liver derived macrophage cell line, HTC, showed the same pattern. They also showed higher protein synthesis at 42°C compared with (41°C) after LPS stimulation. Trout head-kidney macrophages (THM) showed the highest NO responses at 19°C when compared to more typical stream temperatures of 13, 15, and 16°C. They still showed some response at 28 and 37°C. Thus, their macrophages respond at higher temperatures than the fish can tolerate. Stimulated THM cells with LPS at 19°C showed increased protein synthesis compared to 13 and 16°C. We can conclude from our experiments that fish macrophages had a much broader range of temperatures at which they could respond by NO generation and protein synthesis compared to mice and chickens and all had increased responses at fever temperatures.

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Wahl, H. M. "Elihu, Frevler Oder Frommer? Die Auslegung Des Hiobbuches (Hi 32-37) Durch Ein Pseudepigraphon (Testhi 41-43)." Journal for the Study of Judaism 25, no. 1 (1994): 1–17. http://dx.doi.org/10.1163/157006394x00096.

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Kocher, Martin, Rolf-Peter Müller, Dieter Ross, Annette Hoederath, and Horst Sack. "Erratum to “Radiotherapy for treatment of localized gastrointestinal non-Hodgkin's lymphoma” [Radiother. Oncol. 42: 37–41, 1997]." Radiotherapy and Oncology 42, no. 3 (March 1997): 317. http://dx.doi.org/10.1016/s0167-8140(97)82943-x.

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Tupling, A. Russell, Anthony O. Gramolini, Todd A. Duhamel, Hiroya Kondo, Michio Asahi, Shauna C. Tsuchiya, Michael J. Borrelli, et al. "HSP70 Binds to the Fast-twitch Skeletal Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1a) and Prevents Thermal Inactivation." Journal of Biological Chemistry 279, no. 50 (September 14, 2004): 52382–89. http://dx.doi.org/10.1074/jbc.m409336200.

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This study examined whether HSP70 could bind to and protect against thermal inactivation of SERCA1a, the SERCA isoform expressed in adult fast-twitch skeletal muscle. Sarcoplasmic reticulum vesicles prepared from rat gastrocnemius muscle were incubated with purified HSP70 at both 37 and 41 °C for either 30, 60, or 120 min. Maximal SERCA1a activity (μmol/g protein/min) in the absence of HSP70 was reduced progressively with time, with greater reductions occurring at 41 °C compared with 37 °C. HSP70 protected against thermal inactivation of SERCA1a activity at 37 °C but not at 41 °C and only at 30 and 60 min but not at 120 min. HSP70 also protected against reductions in binding capacity for fluorescein isothiocyanate, a fluorescent probe that binds to Lys515in the nucleotide binding domain of SERCA, at 30 and 60 min but not at 120 min, an effect that was independent of temperature. HEK-293 cells were co-transfected with cDNAs encoding rabbit SERCA1a and human HSP-EYFP and subjected to 40 °C for 1 h. Immunohistochemistry revealed nearly complete co-localization of SERCA1a with HSP70 under these conditions. Co-immunoprecipitation showed physical interaction between HSP70 and SERCA1a under all thermal conditions bothin vitroand in HEK-293 cells. Modeling showed that the fluorescein isothiocyanate-binding site of intact SERCA1a in the E2 form lies in its close proximity to a potential interaction site between SERCA1a and HSP70. These results indicate that HSP70 can bind to SERCA1a and, depending on the severity of heat stress, protect SERCA1a function by stabilizing the nucleotide binding domain.

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Ermolenko, K. D. "Toxocariasis. Difficult diagnosis in practice of pediatrician." Medical alphabet, no. 37 (January 15, 2021): 37–41. http://dx.doi.org/10.33667/2078-5631-2020-37-37-41.

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Parasitic nematodes of the genus Toxocara are socio-economically important zoonotic pathogens. These parasites are usually directly transmitted to the human host through the fecal-oral route and can cause toxocariasis and related complications, including allergic and neurological disorders. Although tens of millions of people are estimated to have been exposed to Toxocara spp. or are infected with them, global epidemiological information on the relationship between seropositivity and toxocariasis is limited. Recent results show that in some countries the impact of toxocariasis on human health is increasing. The purpose of this review was to analyze modern data on the epidemiology, pathogenesis, clinical and laboratory manifestations and therapy of toxocariasis. Material and methods. The analysis of publications in PubMed, EMBASE and Web of Science systems in the period from January 1950 to September 2020, highlighting studies documenting the epidemiological, pathogenetic, clinical and laboratory aspects of toxocariasis. In addition, we analyzed clinical cases of toxocariasis among patients of the departments of the Pediatric Research and Clinical Center for Infectious Diseases. The article discusses the basic information about toxocars, summarizes the key aspects of the pathogenesis, diagnosis and treatment of toxocariasis, its prevalence, and gives recommendations for the prevention and control of this disease.

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Noel, Marcus Smith, Aram F. Hezel, David Linehan, Andrea Wang-Gillam, Ferry Eskens, Stefan Sleijfer, Ingrid Desar, et al. "Orally administered CCR2 selective inhibitor CCX872-b clinical trial in pancreatic cancer." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 276. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.276.

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276 Background: CCR2 inhibition decreases tumor-associated macrophages and Treg cells, and increases CD8+ and CD4+ T cells in pancreatic tumors. Single oral doses of 150 mg CCX872-B were well tolerated in patients with pancreatic cancer. The first stage results of the multiple dose part of this study are presented. Methods: Patients with locally advanced or metastatic pancreatic cancer, ECOG score ≤ 2 were studied. Patients received FOLFIRINOX (fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) q2weeks for up to 24 wks plus 150 mg CCX872-B once or twice daily until disease progression or intolerance to CCX872-B. The primary efficacy endpoint is progression-free survival (PFS) at 24 wks. Tumor control rate (TCR) and the objective response rate (ORR), a secondary endpoint, are presented. Results: Fifty patients were enrolled. Baseline: Mean ± SD age: 60 ± 8.6 years, male 52%; primary tumor location: head 57%, body/tail 41%, local recurrence 2%; metastatic disease 78%, ECOG score 0: 62%, ECOG score 1: 38%. Thirty five of 50 patients completed week 12. Most common reasons for early withdrawal were subject request (5 pts) and adverse events typically associated with FOLFIRINOX (4 pts). In the pre-specified analysis population, i.e., those with ≥ 1 post baseline CT scan, tumor control at wk 12 was achieved in 32 of 41 (78%) patients, with 15 of 41 (37%) partial responders, and 17 of 41 (41%) with stable disease. The ORR was 37% (all partial responders) in the primary analysis population (30% when all enrolled patients were included). Thirteen of 21 patients with available CT scan results at week 24 were progression-free. Mean trough CCX872 plasma level was ~8 μg/mL. CCR2 was covered 88% on average by CCX872-B based on receptor occupancy assays. CCX872-B appeared to be well tolerated and the incidence of ≥ Gr 3 AEs was not increased with CCX872-B plus FOLFIRINOX vs historical data with FOLFIRINOX alone. The complete set of PFS data will be available by the end of 2016. Conclusions: CCX872-B plus FOLFIRINOX resulted in a TCR of 78% and an ORR of 30 to 37% with no safety issues ascribed to CCX872-B use. Clinical trial information: NCT02345408.

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Qu, Pingping, Wenru Tian, Tao Li, Zhongling Jiang, Shansong Gao, Zhongjie Tian, and Mingzhi Wang. "Developmental competence and ultrastructural changes of heat-stressed mouse early blastocysts produced in vitro." Current Zoology 55, no. 1 (February 1, 2009): 61–66. http://dx.doi.org/10.1093/czoolo/55.1.61.

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Abstract Mouse early blastocysts were exposed to temperatures of 39°C and 41°C for 2 h, respectively, to determine their developmental competence and ultrastructural changes. The results showed that heat stress at 41°C for 2 h, significantly reduced the percentages of expanded and hatched blastocysts, but not at 39°C for 2 h. The average cell numbers in expanded blastocysts, which developed from early blastocysts heat-stressed at temperatures of 39°C and 41°C, were significantly reduced. The average cell numbers in hatched blastocysts subjected to heat stress were no different from those in the control group cultured at 37°C. The mitochondria of the early blastocysts heat-stressed at 39°C for 2 h, were slightly swollen, but they had recovered after culturing at 37°C for 2 h. However, the mitochondria in the blastocysts heat stressed at 41°C for 2 h were severely swollen, and their number increased. The ribosomes shed from the rough endoplasmic reticulum, and the number of secondary lysosomes in the plasma increased. The integrity of desmosomes was disrupted. The space between the nuclear envelope and the perivitelline membrane enlarged. The fibre fraction and the particulate fraction of nucleoli were separated. The heterochromatin in nucleoli was also increased in its quantity. There were some lamellar-shape structures and heterogeneous dense materials exhibiting in the cytoplasm. The ultrastructural changes induced by heat shock at 41°C for 2 h were not reversible. In conclusion, the damage of heat stress to mitochondria, lysosomes, ribosomes and cell nucleus, may be one of the most important factors that inhibit the normal development of mouse early blastocysts.

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Liu, Kuan-Guan, Xi-Yan Liu, Zong-Jie Guan, Kang Shi, Yu-Mei Lin, and Quan-Ming Wang. "The transformation of polyoxometalates in the formation of intercluster compound [Ag41(α-SiW10O37)(tBuCC)27(CH3CN)3][β-SiW12O40]." Chemical Communications 52, no. 19 (2016): 3801–4. http://dx.doi.org/10.1039/c6cc00524a.

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A unique intercluster comprising a Ag₄₁ cage encapsulating a divacant [α-SiW₁₀O₃₇]¹⁰⁻ anion and a complete [β-SiW₁₂O₄₀]⁴⁻ anion as a counteranion.

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De Filippis, Patrizia, Cinzia Mozzetti, Massimo Amicosante, Gian Loreto D'Alò, Alessandra Messina, Donatella Varrenti, Roberto Giammattei, et al. "Occurrence of Legionella in showers at recreational facilities." Journal of Water and Health 15, no. 3 (March 20, 2017): 402–9. http://dx.doi.org/10.2166/wh.2017.296.

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Critical environments, including water systems in recreational settings, represent an important source of Legionella pneumophila infection in humans. In order to assess the potential risk for legionellosis, we analyzed Legionella contamination of water distribution systems in 36 recreational facilities equipped with swimming pools. One hundred and sixty water samples were analyzed from shower heads or taps located in locker rooms or in bathrooms. By culture method and polymerase chain reaction, 41/160 samples were positive for Legionella from 12/36 recreational centers. Hotels (57.1%) and sports centers (41.2%) were the most contaminated. L. pneumophila serotypes 2–14 (25/41) were more frequently found than serotype 1 (10/41). Samples at temperature ≥30 °C were more frequently positive than samples at temperature <30 °C (n = 39 vs n = 2, p < 0.00001). The presence of L. pneumophila was investigated by comparison with heterotrophic plate count (HPC), an indicator of water quality. The presence of L. pneumophila was associated more frequently with high and intermediate HPC load at 37 °C, therefore should be considered a potential source when HPC at 37 °C is >10 CFU/mL. Maintenance, good hygiene practices, interventions on the hydraulic system and regular controls must be implemented to minimize exposure to L. pneumophila infection risk.

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Kroth, Jerry, Janice McDavit, Cindy Brendlen, Anjlee Patel, and Lisa Zwiener. "Risk-Taking, Death Anxiety, and Dreaming." Psychological Reports 88, no. 2 (April 2001): 514–16. http://dx.doi.org/10.2466/pr0.2001.88.2.514.

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Dream characteristics of 29 women from a graduate program were correlated with scores on the Sensation-Seeking and Death Anxiety scales. Significant positive correlations were obtained between Sensation Seeking and dream frequency (.38), meaningful dreams (.38), and Openness and depth of dreaming (.39) as well as between Thrill-seeking and dream frequency (.41) and meaningful dreams (.41). Death Anxiety scores positively related to the occurrence of nightmares (.37), representations of death in dreams (.55), and recurring nightmares (.38), but no support was found for a relationship between death anxiety and Sensation Seeking.

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Raviraj, Padmini, Aiat Shamsa, Jun Bai, and Rajanishwar Gyaneshwar. "An Analysis of the NSW Midwives Data Collection over an 11-Year Period to Determine the Risks to the Mother and the Neonate of Induced Delivery for Non-Obstetric Indication at Term." ISRN Obstetrics and Gynecology 2013 (September 25, 2013): 1–5. http://dx.doi.org/10.1155/2013/178415.

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Objective. To determine the risks of induced term delivery to the mother and neonate at different gestational ages in the absence of obstetric indications. Study Design. All deliveries in New South Wales (NSW) between 1998 and 2008 were reviewed from the MDC. Uncomplicated pregnancies which were induced for non-obstetric reasons after 37 completed weeks were reviewed. This was a retrospective, historical cohort study, and both maternal and neonatal outcomes were analysed and compared between different gestational age groups. Results. An analysis of the data shows that induction of labour after 37 completed weeks exposes the fetus and mother to different levels of risk at different gestations. Conclusion. In an uncomplicated pregnancy, induction of labour is associated with the highest rate of neonatal complication at 37 weeks as compared with rates at later gestations. With each ensuing week, the neonatal outcome improves. At 40 weeks the likelihood of neonatal intensive care admission, low Apgar scores, and perinatal death rate is at its lowest, and then there is a slight but not significant rise after 41 weeks. The likelihood of caesarean section is the lowest when inductions are carried out at 39 weeks and is the highest at 41 weeks and over.

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Banerjee, Jayanta, Annie Aloysius, Karen Mitchell, Ines Silva, Dimitrios Rallis, Sunit V. Godambe, and Aniko Deierl. "Improving infant outcomes through implementation of a family integrated care bundle including a parent supporting mobile application." Archives of Disease in Childhood - Fetal and Neonatal Edition 105, no. 2 (June 21, 2019): 172–77. http://dx.doi.org/10.1136/archdischild-2018-316435.

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ObjectiveThe aim of the Integrated Family Delivered Care (IFDC) programme was to improve infant health outcomes and parent experience through education and competency-based training.DesignIn collaboration with veteran parents’ focus groups, we created an experienced co-designed care bundle including IFDC mobile application, which together with staff training programme comprised the IFDC programme. Infant outcomes were compared with retrospective controls in a prepost intervention analysis.Main outcome measuresThe primary outcome measure was the length of stay (LOS).ResultsBetween April 2017 and May 2018, 89 families were recruited; 37 infants completed their entire care episode in our units with a minimum LOS >14 days. From a gestational age (GA) and birth weight-matched retrospective cohort, 57 control infants were selected. Data were also analysed for subgroup under 30 weeks GA (n=20).Infants in the IFDC group were discharged earlier: median corrected GA (36+0 (IQR 35+0–38+0) vs 37+1 (IQR 36+3–38+4) weeks; p=0.003), with shorter median LOS (41 (32–63) vs 55 (41–73) days; p=0.022). This was also evident in the subgroup <30 weeks GA (61 (39–82) vs 76 (68–84) days; p=0.035). Special care days were significantly lower in the IFDC group (30 (21–41) vs 40 (31–46); p=0.006). The subgroup of infants (<30 weeks) reached full suck feeding earlier (median: 47 (37–76) vs 72 (66–82) days; p=0.006).ConclusionThis is the first reported study from a UK tertiary neonatal unit demonstrating significant benefits of family integrated care programme. The IFDC programme has significantly reduced LOS, resulted in the earlier achievement of full enteral and suck feeds.

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Journal articles on the topic '37-41'

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