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Journal articles on the topic '377.13(SE=5.96) for local'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Conroy, T., M. Ducreux, C. Lemanski, et al. "Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): Definitive analysis of the intergroup ACCORD 03 trial." Journal of Clinical Oncology 27, no. 15_suppl (2009): 4033. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4033.

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4033 Background: Concomitant radiochemotherapy (CRT) is the standard treatment of LAAC. The addition of an ICT (2 cycles of 5 FU-Cisplatin) and of a higher dose of irradiation boost (HDRT) to CRT were evaluated in a factorial 2X2 arms trial (A= ICT; B=ICT+HDRT; C= Reference arm = Pelvic RT 45 Gy/25 fractions with 2 cycles of 5FU-Cisplatin and a boost of 15 Gy; D= HDRT). The aim of the study was to detect a increase from 70 to 85% of colostomy-free survival (CFS) at 3 years. Methods: 307 pts with T2 > 4 cm or T3-T4 Nx or any T, N1–3 M0 LAAC were included. Mean age was 59 y and sex-ratio was

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Diaz, Fernando G., and Ghaus M. Malik. "Carotid Endarterectomy." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 4, no. 2-3 (2017): 46–54. http://dx.doi.org/10.22290/jbnc.v4i2-3.103.

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Carotid endarterectomy should be considered for patients with symptoms of focal cerebral ischemia, when it can be performed with a combined morbidity and mortality below the annual risk of stroke (5%). The experience with 815 carotid endartectomies perforformed from 1979 to 1992 is presented. There were 530 (65%) men and 285 (35%) women of ages from 34 to 82 (median 65); risk factors included diabetes mellitus 196 (24%), hypertension 554 (68%), and smoking 570 (70%). Clini¬cal presentation consisted of transient ischemic attacks 464 (57%), cerebral infarction with minimal neurological residual

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de Crevoisier, R., T. Messai, A. Plantade, et al. "Impact of PSA decrease at the end of radiotherapy for localized prostate cancer on clinical recurrence and specific cause survival." Journal of Clinical Oncology 25, no. 18_suppl (2007): 15501. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15501.

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15501 Background: The objective was to identify early predictors of outcome in a large retrospective series of patients treated by external beam radiotherapy only (without androgen deprivation). All the patients had a PSA at the 6th week (PSA6wRT) in the course of RT. Methods: From 1990 to 2004, 409 pts with localized prostate cancer were treated by RT. Median pretreatment PSA (PSApreRT) was 13 ng/mL (0.5–133). Clinical stage was T1 (26%), T2 (60%), and T3 (14%). Gleason score was 4–6 (59%), 7 (31%) and 8–10 (10%). Prognosis was classified as low risk (24%), intermediate (39%) and high risk (3

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Bundred, Nigel, Nuria Porta, Adrian Murray Brunt, et al. "Abstract P2-13-08: Combined peri-operative lapatinib and trastuzumab in early HER2-positive breast cancer - Long term results of the randomized UK EPHOS-B trial." Cancer Research 82, no. 4_Supplement (2022): P2–13–08—P2–13–08. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-13-08.

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Abstract Background: EPHOS-B is a multi-centre randomized trial designed to investigate whether anti-HER2 therapy given 11 days pre-surgery inhibited proliferation and/or increased apoptosis in HER2-positive early breast cancer. Significant differences in Ki67 response (≥30% change between baseline and surgery) were observed between treatment groups and control, although no significant increases in apoptosis were seen [1]. We report here 5-year outcomes and their association with peri-operative response, including post-hoc exploratory analyses on stromal tumour infiltrating lymphocytes (TILs).

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Mrdutt, Mary, Courtney N. Day, Amy C. Degnim, Judy Boughey, and Robert Antonio Leon-Ferre. "Abstract P5-01-07: Use of Neoadjuvant Chemotherapy for Local and Regionally Recurrent Triple Negative and HER2+ Breast Cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–01–07—P5–01–07. https://doi.org/10.1158/1557-3265.sabcs24-p5-01-07.

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Abstract Introduction: Neoadjuvant chemotherapy (NACT) for early-stage breast cancer enables de-escalation of local therapy and tailored adjuvant therapy based on pathologic response. Data on the use of NACT for local and/or regionally recurrent (LRR) breast cancer (BC) is sparse. Herein, we evaluated use of NACT over time for triple negative (TN) and HER2+ LRR BC and impact of pathologic response on oncologic outcomes. Methods: We identified patients with first TN or HER2+ invasive LRR BC treated surgically at our institution from 9/2008-5/2024. Patients presenting with distant metastasis, in

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Evenhuis, Richard, Michaël P. A. Bus, Simen Sellevold, et al. "Proximal humeral endoprosthetic reconstruction for tumour defects." Bone & Joint Open 6, no. 6 (2025): 715–23. https://doi.org/10.1302/2633-1462.66.bjo-2025-0018.

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AimsTumour defects of the proximal humerus can be reconstructed using hemiarthroplasty, reverse shoulder arthroplasty (RSA), or anatomical total shoulder arthroplasty (TSA). This study aimed to evaluate clinical and functional outcomes of reconstructions of proximal humeral tumour defects with MUTARS endoprostheses.MethodsA total of 165 reconstructions were included: 98 (59%) hemiarthroplasties, 61 (37%) RSAs, and six (4%) TSAs. Median age was 54 years (IQR 31 to 68). Median follow-up time was 5.9 years (IQR 2.83 to 10.50). Competing risks models were employed to estimate the cumulative incide

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Romero-Kusabara, Ivana Lopes, José Vital Filho, Nilza Maria Scalissi, et al. "Distinct inflammatory gene expression in extraocular muscle and fat from patients with Graves’ orbitopathy." European Journal of Endocrinology 176, no. 4 (2017): 481–88. http://dx.doi.org/10.1530/eje-16-0945.

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Objective This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). Design and methods A prospective study design was used to evaluate 34 TED patients and 38 healthy controls. OF was harvested from 33 TED patients and 27 controls. EOM biopsies were obtained from 32 TED patients and 18 controls. Samples were examined by real-time PCR and evaluated using appropriate statistical analyses with a significance cut-off of P < 0.05. R

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El-Achkar, Adnan, Mustafa Khader, Ala’a Farkouh, Joelle Hassanieh, Bhaskar Somani, and Mohammed Shahait. "Role of Cryoablation for the Treatment of cT1b Kidney Lesions: Outcomes of a Systematic Review." Société Internationale d’Urologie Journal 4, no. 3 (2023): 211–22. http://dx.doi.org/10.48083/imbm6087.

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IntroductionThe American Urological Association (AUA) and the European Association of Urology (EAU) currently recommend partial nephrectomy (PN) over ablation for cT1b lesions. However, recent series have shown comparable outcomes for cryoablation (CA) when compared to PN, making it an appealing alternative for a select group of patients. The objective of this manuscript is to assess treatment outcomes and complications of CA for cT1b lesions.MethodsUsing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was done on MEDLINE and Cochr

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Evayanti, Ni Wayan Wahyu, Misnah Misnah, and Bau Ratu. "Contribution of Traditional Mehule Games to Improve Understanding of Local Wisdom Material and Students' Interest in Learning Science Subjects in Grade IV of SDN Were'a." Journal of Education Method and Learning Strategy 3, no. 02 (2025): 386–99. https://doi.org/10.59653/jemls.v3i02.1753.

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Abustang, Waddi Fatimah Perawati Bte. 2020. “The Influence of Learning Interest on Social Studies Learning Outcomes.” 7:1–112.Aqillah, Nurul, Zaini Siti, Nor Ayna, Binti Mohd, Ayu Mohd, Zairul Masron, Faculty of Management, Maklumat Uitm, Cawangan Selangor, Puncak Perdana Campus, Shah Alam, and Selangor Abstract. 2021. "JOURNAL OF MALAYSIAN ORAL HISTORY ISSN 2600-7088 VOL. 5 ISU 2 OCTOBER 2021 The Art of Rotation: Traditional Gasing Pangkah Which Is Increasingly Disappearing." 37–54.Atmaja, Rosko, I. Wayan Ramantha, and I. Wayan Suartana. 2017. “Indicators of Understanding.” E-Journal of Econo

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Lin, Thomas S., Beth Fischer, Mollie E. Moran, et al. "Flavopiridol, Fludarabine and Rituximab Is a Highly Active Regimen in Indolent B-Cell Lymphoproliferative Disorders Including Mantle Cell Lymphoma." Blood 106, no. 11 (2005): 944. http://dx.doi.org/10.1182/blood.v106.11.944.944.

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Abstract The cyclin-dependent kinase inhibitor flavopiridol was inactive when given by 24–72-hr infusion, but 1-hr IV bolus dosing demonstrated clinical activity in mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). Flavopiridol induces apoptosis independent of p53 and may be able to eliminate tumor cells resistant to fludarabine and rituximab. We performed a phase I dose escalation study of flavopiridol in combination with fludarabine and rituximab (FFR) in patients (pts) with MCL, CLL and indolent B-cell non-Hodgkin’s lymphoma (NHL). Pts had ANC ≥ 1500, hemoglobin ≥ 9.0, plat

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Milano, Anthony F. "Cancer of the Larynx–20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration and ICD-O-3 Topographic Primary Sites-Codes C32.0-9: A Systematic Review of 43,103 Cases for Diagnosis Years 1975-2017: (NCI SEER*Stat 8.3.9)." Journal of Insurance Medicine 51, no. 2 (2024): 92–110. http://dx.doi.org/10.17849/insm-51-2-92-110.1.

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Background .—Laryngeal malignancy, “voice box” cancer, is uncommon with 12,620 estimated new cases and 3770 deaths in the United States in 2021,1 and represents only 6.2% of all respiratory system malignancies. The most significant risk factors are alcohol and tobacco consumption. Almost all cases (98%) of laryngeal cancer arise in the squamous epithelium, and in this analysis more than 75% are of well-or-moderately differentiated histopathology (Grades I&II). Local stage cancer (SEER Historic Staging) was more common than regional and distant stages combined (55.3% vs 44.7%). Tumors may a

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Heidenreich, Axel, Constantin Rieger, Lucas Kastner, Felix Seelemeyer, and David Pfister. "Cytoreductive radical prostatectomy (cRP) in the management of patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC)." Journal of Clinical Oncology 41, no. 6_suppl (2023): 161. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.161.

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161 Background: Although still discussed controversially, cRP represents a therapeutic option for mHSPC patients in the context of a multimodality approach. It was the purpose of our study to retrospectively review the oncological and functional outcome of a single-center cohort of cRP patients. Methods: A total of 134 mHSPC patients underwent cRP with pelvic lymphadenectomy. All patients received neoadjuvant androgen deprivation therapy (ADT, n = 34), ADT + docetaxel (n=15), or ADT plus ABI/ENZA/APA (n=85) for 6 months which was continued postop. Follow-up studies were performed at 3-month in

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Bergeron, Christophe, David Perol, Helene Pacquement, et al. "Treatment of Childhood T Cell Lymphoblastic Lymphoma (TLL), Results of the SFOP LMT96." Blood 106, no. 11 (2005): 3326. http://dx.doi.org/10.1182/blood.v106.11.3326.3326.

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Abstract After LMT81 and SFOP LMT89 protocols (both modified LSA2L2), the SFOP LMT96 was designed according to BFM 86 back bone (Reiter and al, J Clin Oncol, 13:359.1995). The aim of LMT96 protocol was to increase chemotherapy intensity early (day 8) and late (after the intensification phase). From February 1997 to December 2003, 83 unselected patients (pts) with newly diagnosed TLL were included in LMT96 protocol: classic corticosteroid prephase (d1 to d7); induction phase with Cyclophosphamide(CPM: 1g/m2) and high dose methotrexate (HDMTX: 3g/m2 infusion over 3h) at d8, followed by Vincristi

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Maqbool, Shahida, Syed Muhammad Abul Hasan Ali, Hafsa Niaz, Syed Muhammad Ali Akbar, Sobia Siddique, and Sarah Shami. "Knowledge and Attitude towards Anaphylaxis Reaction by Local Anesthesia among Dental Practitioners." Pakistan Journal of Medical and Health Sciences 17, no. 2 (2023): 562–65. http://dx.doi.org/10.53350/pjmhs2023172562.

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Background: Anaphylaxis or Type I hypersensitivity response is an acute, severe, and potentially life-threatening response to an allergen. It occurs as an immune mediated reaction due to the release of mediators by mast cells. The anaphylactic response involves skin, cardiovascular, respiratory or gastrointestinal systems. In dental settings, anaphylaxis can be faced in reaction to multiple medications including the administration of local anesthetic agents. The reaction involves difficulty in breathing, light headedness, wheezing or clammy skin. The knowledge and attitude of the treating dent

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Hajj, Carla, Florence Huguet, Abraham Jing-Ching Wu, et al. "Intensity-modulated radiation therapy (IMRT) in patients with locally advanced pancreatic cancer (LAPC)." Journal of Clinical Oncology 33, no. 3_suppl (2015): 377. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.377.

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377 Background: To assess IMRT safety and evaluate local control and resectability among patients with LAPC treated with induction CT followed by IMRT. Methods: We reviewed records of 134 LAPC patients treated with CT (median duration 3.2 months) followed by IMRT (median dose 56 Gy) between 11/2006 and 11/2012. Patients had LAPC based on T4 disease or unreconstructable involvement of portal vein/hepatic artery on imaging (n=102) or were found to be unresectable after an attempted resection (n=32). Induction CT was gemcitabine-based (n=98) or FOLFIRINOX (n=32); concurrent CT was gemcitabine in

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Okazaki, Dai, Yuta Shibamoto, Takeshi Yanagi, et al. "Local radiotherapy for pleural dissemination of thymic tumors after initial treatment." Journal of Radiation Research 62, no. 4 (2021): 676–81. http://dx.doi.org/10.1093/jrr/rrab046.

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Abstract Pleural dissemination is a common pattern of failure after initial treatment of thymoma and thymic carcinoma, but there is no standardized treatment. As these tumors are relatively radiosensitive, we investigated the effectiveness of radiotherapy. Twenty patients underwent 33 series of local radiotherapy for 96 pleural dissemination lesions after initial treatment. Conventional radiotherapy (CRT), tomotherapy, and combination of the two were employed in 19, 13, and 1 series, respectively. The median follow-up period after the first irradiation for pleural dissemination was 46 months (

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Tan, Janice Ser Huey, Charles Xian-Yang Goh, Youquan Li, et al. "68-Ga prostate-specific membrane antigen-PET as a diagnostic and clinical decision making tool in biochemical recurrences post-radical prostatectomy." Journal of Clinical Oncology 36, no. 6_suppl (2018): 377. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.377.

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377 Background: In patients with biochemical relapse (BCR) following radical prostatectomy (RadP), risk stratification by clinical indices alone is suboptimal for identifying subgroups likely to benefit from salvage radiotherapy (RT). It is also recommended that combination hormonal therapy (HT)-RT improves rates of salvage and survival, hence the need for a clinical tool to better stratify patients for RT and HT-RT; the latter approach for patients at risk of occult metastases. Herein, we investigated the role of 68Ga-Prostate-specific Membrane Antigen (PSMA)-PET in the detection of regional

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Llacsa Mamani, Javier, Mario Viera Valencia, and Carlos Gómez Bravo. "Efecto de la suplementación con dos genotipos del forraje de cebada (<i>Hordeum vulgare L.</i>) sobre producción y calidad de leche." Revista de Investigaciones Veterinarias del Perú 35, no. 6 (2024): e27621. https://doi.org/10.15381/rivep.v35i6.27621.

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The aim of this research was to evaluate the effect of supplementation with two barley forage genotypes on milk production and quality in grazing cows. The genotypes evaluated were a local barley (Hordeum vulgare L.) and UNALM 96 M6h-326 barley in the district of Sincos, Junín (Peru). The experiment was conducted with 16 Brown Swiss - creole crossbred cows in second lactation and body weight of 385 ± 17 kg. Under a simple change design, the animals were divided into two groups for supplementation with 4 kg/day with one of the two barley forages. Supplementation was carried out in two stages of

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GRANDOLFO, M. E., E. MEDDA, F. NOVELLO, B. RIDOLFI, and The STUDY GROUP. "Seroepidemiological evaluation of 1989–91 mass vaccination campaigns against measles, in Italy." Epidemiology and Infection 121, no. 3 (1998): 645–52. http://dx.doi.org/10.1017/s095026889800154x.

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In 1989–91 anti-measles vaccination campaigns were conducted in several Italian regions to vaccinate all children aged between 13 months and 10–12 years without a history of measles or measles vaccination. This study was conducted to evaluate serological status after the mass vaccination campaigns. In 1994, capillary blood samples were collected from randomly selected children, aged 2–14 years, living in 13 local health units. Antibody titres were determined by ELISA. Blood spot samples were analysed for 4114 (75·6%) of 5440 selected children. Among the 835 that reported measles before 1990, 8

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Friedman, William A., Gregory J. Murad, Patrick Bradshaw, et al. "Linear accelerator surgery for meningiomas." Journal of Neurosurgery 103, no. 2 (2005): 206–9. http://dx.doi.org/10.3171/jns.2005.103.2.0206.

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Object. In this paper the authors review the results of a single-center experience in the use of linear accelerator (LINAC) surgery for radiosurgical treatment of meningiomas. Methods. A retrospective analysis of all patients treated with LINAC surgery for meningiomas between May 1989 and December 2001 was performed. All patients participated in follow-up review for a minimum of 2 years, and no patients were excluded. Two hundred ten patients were treated during the study interval. The actuarial local control rate for benign tumors was 100% at both 1 and 2 years, and 96% at 5 years. The actuar

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Tamwifi, Irfan, Zulkarnain, Eliyyil Akbar, and Abidah. "Early Childhood Multicultural Education in the Islamic Sharia Area." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 216–28. http://dx.doi.org/10.21009/jpud.172.03.

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Cases encountered in the field related to intolerance in early childhood include children making fun of each other regarding social status, cultural differences, religious differences, skin color, and dialect differences. Early childhood in the field of Islamic law is prone to conflict problems. The purpose of this writing is to describe multicultural learning practices in areas of Islamic law. The method used is field research with a qualitative approach. The result of this writing is the implementation of multicultural learning at early childhood education institutions in Budidharma Kinderga

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Dr., Sobia Jabeen Dr Aaisha Dr Mutahira Mannan. "A CROSS-SECTIONAL RESEARCH TO DETERMINE THE DISEASE PATTERN WITH THE INVOLVEMENT OF THE PATIENT'S DEMOGRAPHICS & CLINICAL OUTCOMES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11658–63. https://doi.org/10.5281/zenodo.1480930.

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<em>Objectives: </em><em>Based on the symptoms and clinical findings, the exploration of patterns of diseases at a local territory hospital was useful. The focus of the study was to determine the disease patterns and associated demographics for different organic systems at a primary healthcare centre. </em> <em>Methods: This was a </em><em>cross-sectional research conducted at Services Hospital, Lahore. Some secondary information worked out through OPD register for a period of six months (01 March to 30 August 2017). The purpose of the study was to find out the age, sex and organ system wise d

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Baker, R. L., A. H. Carter, C. A. Morris, and D. L. Johnson. "Evaluation of eleven cattle breeds for crossbred beef production: performance of progeny up to 13 months of age." Animal Science 50, no. 1 (1990): 63–77. http://dx.doi.org/10.1017/s0003356100004475.

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ABSTRACTEleven sire breeds were evaluated in New Zealand from the performance of their calves at two sites using Aberdeen-Angus cows, and at a third site using Angus and Hereford cows. The experiment was carried out over 5 years, generating a total of 4519 calves by 161 different sires. There were seven recently imported sire breeds, Blonde d'Aquitaine, Charolais, Chianina, Limousin, Maine Anjou, Simmental (including strains from four countries) and South Devon, and four local breeds, Angus, Friesian, Hereford and Jersey. Overall, 92% of calves survived at birth and through to weaning, with a

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Singh, Sanjeev K., M. S. Muthu, Ravindran Revand, and Maloy B. Mandal. "Intra-arterial Instillation of a Nociceptive Agent Modulates Cardiorespiratory Parameters Involving 5-HT3 and TRPV1 Receptors in Anesthetized Rats." Cardiovascular & Hematological Disorders-Drug Targets 21, no. 1 (2021): 46–54. http://dx.doi.org/10.2174/1871529x21666210408101442.

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Background: Since long back, it has been a matter of discussion regarding the role of peripheral blood vessels in the regulation of cardiorespiratory (CVR) system. Objective: The role of 5-HT3 and TRPV1 receptors present on perivascular nerves in elicitation of CVR reflexes was examined after intra-arterial instillation of bradykinin in urethane anesthetized rats. Materials and Methods: Femoral artery was cannulated retrogradely and was utilized for the instillation of saline/agonist/antagonist and recording of blood pressure (BP), using a double ported 24G cannula. BP, respiration and ECG wer

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Subedi, Subash, Saraswati Neupane, Sailendra Yadav, and Jiban Shrestha. "Field screening of linseed genotypes against alternaria blight (Alternaria lini)." Journal of Agriculture and Natural Resources 6, no. 1 (2023): 96–104. http://dx.doi.org/10.3126/janr.v6i1.71941.

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Linseed (Linum usitatissimum L.) is a promising but underexplored oilseed crop in Nepal, with considerable expansion potential. However, it faces a significant threat from leaf blight disease, caused by Alternaria lini resulting in notable yield reductions. This study aimed to identify genetic sources of resistance to this pathogen. Fourty-two linseed genotypes, including resistant check ACC#7622 and susceptible check Sarlahi local, underwent disease resistance screening over two years (2021-2022) in field disease screening nurseries at the Oilseed Research Program, Sarlahi, using an incomplet

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Du, Lifang, Jihong Wang, Yong Yang, et al. "Continuous Detection of Diurnal Sodium Fluorescent Lidar over Beijing in China." Atmosphere 11, no. 1 (2020): 118. http://dx.doi.org/10.3390/atmos11010118.

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Based on application of the atomic filter technology in a signal detection system of lidar, the diurnal observation of sodium lidar were obtained using the system at the National Space Science Center of the Chinese Academy of Sciences at Beijing Yanqing station (40.5° N, 116° E) in April 2014. During the lidar observation period, among the 103 cases of continuous daytime observations, the longest time was 181 h. In the case of a continuous observation period of 5 days (13–18 October 2014), the signal-to-noise ratio reached to 19:1 at 12:00–13:00 Local Time of the daytime, when the spatial and

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Balar, Arjun Vasant, Ashish M. Kamat, Girish S. Kulkarni, et al. "Pembrolizumab for the treatment of patients with high-risk (HR) non-muscle-invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guérin: Extended follow-up of KEYNOTE-057 cohort A." Journal of Clinical Oncology 39, no. 6_suppl (2021): 451. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.451.

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451 Background: Pembrolizumab (pembro) was approved in January 2020 for treatment of HR NMIBC based on interim results from 96 patients (pts) in the open-label, single-arm, multicenter, phase II KEYNOTE-057 (NCT02625961) study. Here we present updated efficacy and safety results with extended minimum follow-up of 26.3 mo from KEYNOTE-057 cohort A. Methods: Pts aged ≥18 years with histologically confirmed Bacillus Calmette-Guérin (BCG)–unresponsive HR carcinoma in situ (CIS), with or without papillary tumors, who were ineligible for or declined radical cystectomy (RC) received pembro 200 mg Q3W

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Doyen, Jerome, Eric Francois, Anne-Claire Frin, et al. "Contact x-ray brachytherapy 50 kV (CXB) for organ preservation in T2 T3a-b rectal cancer: Lyon-Nice experience in 120 patients." Journal of Clinical Oncology 33, no. 3_suppl (2015): 676. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.676.

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676 Background: Organ preservation (avoiding TME surgery) for T2 T3 a-b rectal cancer is a field of active clinical research. Contact X Ray CXB combined with external beam radiotherapy (EBRT) ± concurrent chemotherapy (CRT) is an attractive method to achieve clinical complete response (cCR) and consequently rectal preservation. We report an overview of 120 patients treated with CXB+EBRT over a 25 year period in Lyon since 1986 and then in Nice until 2012. Methods: Between 1986 and 2012, 120 patients presenting rectal adenocarcinoma T2 T3a-b (distal rectum: 87; middle rectum: 33) were treated w

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Risselada, Marije, Robyn R. McCain, Miriam G. Bates, and Makensie L. Anderson. "Silver nanoparticles can be sampled by ultrafiltration probe but elution into & recovery from plasma and Dulbecco’s Phosphate Buffered Saline differs in vitro." PeerJ 12 (October 24, 2024): e18388. http://dx.doi.org/10.7717/peerj.18388.

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Locally sustained release antimicrobials such as silver nanoparticles (AgNPs) might prove useful in combating local infections. Their elution has been investigated in Phosphate Buffered Saline (PBS) including from poloxamer 407 (P407). No information exists on possible interactions with proteins, nor have ultrafiltration (UF) probes been evaluated to measure Ag. These investigations would provide helpful data prior to investigating the sustained release after subcutaneous implantation in vivo over time. We compared (1) the influence of elution fluid on AgNP elution, and (2) UF probe and direct

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Verco, Shelagh, Holly Maulhardt, Alyson Marin, and Antony Verco. "Safety of locally administered large surface area microparticle paclitaxel and docetaxel in combination with standard of care cancer therapies." Journal of Clinical Oncology 41, no. 16_suppl (2023): e15187-e15187. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15187.

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e15187 Background: The safety of local delivery of large surface area microparticle paclitaxel (LSAM-PTX) or docetaxel (LSAM-DTX) to solid tumors has been evaluated in Phase 1/2 trials across 156 subjects with 43% (67/156) on various concurrent standard of care (SOC) therapies. Local administration of LSAM-PTX or LSAM-DTX leads to a reduction in systemic drug exposure and drug-related adverse events (AE) and may reduce toxicities encountered in combination systemic treatment regimens. This report summarizes safety findings in subjects co-administered LSAM-PTX or LSAM-DTX and common SOC therapi

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Boyce-Fappiano, David, Olsi Gjyshi, Todd A. Pezzi, et al. "Spine stereotactic radiosurgery for metastatic thyroid cancer: a single-institution experience." Journal of Neurosurgery: Spine 32, no. 6 (2020): 941–49. http://dx.doi.org/10.3171/2019.12.spine191269.

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OBJECTIVEPatients with metastatic thyroid cancer have prolonged survival compared to those with other primary tumors. The spine is the most common site of osseous involvement in cases of metastatic thyroid cancer. As a result, obtaining durable local control (LC) in the spine is crucial. This study aimed to evaluate the efficacy of spine stereotactic radiosurgery (SSRS) in patients with metastatic thyroid cancer.METHODSInformation on patients with metastatic thyroid cancer treated with SSRS for spinal metastases was retrospectively evaluated. SSRS was delivered with a simultaneous integrated b

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Geubels, Barbara M., Vincent M. Meyer, Henderik L. van Westreenen, Geerard L. Beets, and Brechtje A. Grotenhuis. "Role of Local Excision for Suspected Regrowth in a Watch and Wait Strategy for Rectal Cancer." Cancers 14, no. 13 (2022): 3071. http://dx.doi.org/10.3390/cancers14133071.

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Rectal cancer patients with a clinical complete response to neoadjuvant (chemo)radiation are eligible for Watch and Wait (W&W). For local regrowth, total mesorectal excision (TME) is considered the standard of care. This study evaluated local excision (LE) for suspected local regrowth. From 591 patients prospectively entered into a national W&W registry, 77 patients with LE for regrowth were included. Outcomes analyzed included histopathologic findings, locoregional recurrence, long-term organ preservation, and colostomy-free and overall survival. In total, 27/77 patients underwent ear

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Geerts, Willie J. C., Ard Jonker, Louis Boon, et al. "In Situ Measurement of Glutamate Concentrations in the Periportal, Intermediate, and Pericentral Zones of Rat Liver." Journal of Histochemistry & Cytochemistry 45, no. 9 (1997): 1217–29. http://dx.doi.org/10.1177/002215549704500905.

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We developed a quantitative histochemical assay for measurement of local glutamate concentrations in cryostat sections of rat liver. Deamination of glutamate by glutamate dehydrogenase (GDH) was coupled to the production of formazan and formazan precipitation was used for colorimetric visualization. The method was tested and validated with gelatin model sections with known glutamate concentrations. Calibration graphs showed linear relationships with high correlation coefficients (>96%) between glutamate concentrations or section thickness and absorbance values. The method was reproducible,

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Yeung, Rosanna, Thomas Rackley, Britta Weber, et al. "Stereotactic body radiotherapy for unresectable hepatocellular carcinoma: A population based analysis of tumors up to 15 cm." Journal of Clinical Oncology 34, no. 4_suppl (2016): 322. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.322.

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322 Background: Stereotactic body radiotherapy (SBRT) has an emerging role for patients with hepatocellular (HCC). The purpose of this study is to describe the efficacy of HCC SBRT at a population level without any tumor size restriction. Methods: A retrospective study of the first 49 HCC patients treated with SBRT between March 2011-July 2015 at the British Columbia Cancer Agency was conducted. All patients were either ineligible for or failed standard local therapies (partial hepatectomy, radiofrequency ablation, percutaneous ethanol injection, transarterial chemoembolization, or radioemboli

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Chiang, Anne C., Kristen McNiff, Pamela Kadlubek, Michael N. Neuss, and Jacobson Joseph. "Assessment of quality improvement efforts by ASCO’s Quality Oncology Practice Initiative (QOPI) participants." Journal of Clinical Oncology 31, no. 31_suppl (2013): 55. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.55.

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55 Background: More than 600 practices have participated in ASCO’s QOPI since 2006. 192 have achieved certification through the QOPI Certification Program (QCP) since 2010. QOPI assesses greater than 150 performance metrics, organized into modules; QCP evaluates 20 chemotherapy-related standards. QI efforts resulting from QOPI/QCP participation have not been assessed, e.g. which measure areas or standards are preferentially selected by practices for local QI projects. Methods: A survey was sent to 1,450 participants at 850 practices to assess which measure modules/standards were selected by QO

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Bilal Khan, Ikram Alam, Sajjad Ullah, and Bakht Jamal. "Incidence of infection in carpal tunnel surgery with and without the use of local antibiotics." Journal of the Pakistan Medical Association 74, no. 1 (2023): 21–25. http://dx.doi.org/10.47391/jpma.6930.

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Objective: To compare the infection rate in patients who underwent carpal tunnel surgery with and without instilling local antibiotics into the surgical wound. Method: The retrospective cohort study was conducted at the Department of Surgery, Unit of Neurosurgery, Government Naseer Ullah Babar Memorial Hospital, Peshawar, Pakistan, and comprised data from July 2019 to July 2021 related to non-diabetic patients without any comorbidity who had undergone fresh carpal tunnel surgery. The cases had been operated by two surgeons having a different approach to preventing infection in carpal tunnel su

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Aliyu, Y. M., Halima Shehu, and Ngamarju John Mamza. "ASSESSMENT OF WOMEN PARTICIPATION IN GROUNDNUT PRODUCTION IN HAWUL LOCAL GOVERNMENT AREA OF BORNO STATE, NIGERIA." Nigerian Journal of Agriculture and Agricultural Technology 2, no. 2 (2022): 122–32. http://dx.doi.org/10.59331/njaat.v2i2.347.

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The study assessed women participation in groundnut production in Hawul local government area of Borno State, Nigeria. Multi-stage sampling procedure was used in drawing 100 respondents for this study. Information was collected using structured questioners. Both descriptive and inferential statistics were used to analyse the data, description statistics used include: frequencies, means and percentages, the inferential statistics used was multiple regression model. The farm size of women in groundnut production where that majority (54%) had less than 5ha, 23% had 9 to 12ha, 12% had 9 to 12ha an

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Hyelnasinyi, C. N., C. Nathan, and G. G. Adamu. "The Concept of Waste to Wealth Market Operation in Mubi North Local Government Area of Adamawa State." Greener Journal of Environment Management and Public Safety 12, no. 1 (2024): 50–59. https://doi.org/10.15580/gjemps.2024.1.112024172.

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The concept of waste to wealth which is the transformation of waste from an exhausted utility to a valuable commodity as a mechanism for effective solid waste management is yet to be properly utilized in Mubi north local government area of Adamawa state. The objectives included to identify the challenges facing waste market operation in Mubi North Local Government area. Questionnaires were distributed to 200 people. The numbers of respondents were evenly distributed on gender basis within the age group of 20-80 years. The result of the research revealed that 96% of the respondents are concerne

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Muire, Preeti Judith, Lauren H. Mangum, Lee C. Mangum, Gerardo R. Garcia, Desiree R. Romano, and Joseph C. Wenke. "Characterization of the local and systemic temporal changes to the lipid mediator and cytokine cascades following osteotomy and polytrauma." Journal of Immunology 204, no. 1_Supplement (2020): 144.3. http://dx.doi.org/10.4049/jimmunol.204.supp.144.3.

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Abstract Polytrauma (PT) inducesglobal changes to inflammatory signaling, contributing to delayed fracturehealing. In a rat model of PT encompassing burn, blunt trauma, and osteotomy, we characterized the local and systemic temporal changes to the lipid mediator(LM) cascade, circulating white blood cells (WBCs), and local levels of growthfactors (GF)s and cytokines. Male rats received either a non-critical 3mmfemoral osteotomy (OST) or PT trauma procedures and were survived for 6, 24,48, 72, 96, 168, or 240hrs and blood, plasma, and fractured femurs werecollected. Whole femurs were homogenized

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Oshikane, Tomoya, Motoki Kaidu, Eisuke Abe, et al. "A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer." Journal of Radiation Research 62, no. 3 (2021): 525–32. http://dx.doi.org/10.1093/jrr/rrab006.

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Abstract We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy twice a day with EBRT 39 Gy/13 fractions.

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Ferrinho, Paulo, Huib Cornielje, and S. G. Reinach. "A profile of patients attending the physiotherapy department at the Alexandra Health Centre and University Clinic." South African Journal of Physiotherapy 48, no. 4 (1992): 56–57. http://dx.doi.org/10.4102/sajp.v48i1.732.

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During 1989 the Alexandra Health Centre and University Clinic (AHC) experimented with a health information system to determine a profile of the patients presenting at the AHC physiotherapy department.Data were analysed for 1408 patients. The age distribution was 2% (n=33): 0-4 years of age, 5% (n-74): 5-14 years, 85% (n-1186): 15-59 years and 8% (n=108): over 60 years (no data on 1%, n=7).31% (n=439) had neck and back problems, 30% (n-419) had problems related to the arms, 22% (n-303) had lower limb problems, 13% (n=185) had hand problems, 4% (n=56) had problems associated with burns, 3% (n=48

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Ferrinho, Paulo, Huib Cornielje, and S. G. Reinach. "A profile of patients attending the physiotherapy department at the Alexandra Health Centre and University Clinic." South African Journal of Physiotherapy 48, no. 4 (1992): 56–57. http://dx.doi.org/10.4102/sajp.v48i4.732.

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During 1989 the Alexandra Health Centre and University Clinic (AHC) experimented with a health information system to determine a profile of the patients presenting at the AHC physiotherapy department.Data were analysed for 1408 patients. The age distribution was 2% (n=33): 0-4 years of age, 5% (n-74): 5-14 years, 85% (n-1186): 15-59 years and 8% (n=108): over 60 years (no data on 1%, n=7).31% (n=439) had neck and back problems, 30% (n-419) had problems related to the arms, 22% (n-303) had lower limb problems, 13% (n=185) had hand problems, 4% (n=56) had problems associated with burns, 3% (n=48

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Bao, Alicia, Andrew R. Barsky, Russell Maxwell, et al. "Long-term Clinical Outcomes in Favorable Risk Prostate Cancer Patients Receiving Proton Beam Therapy." International Journal of Particle Therapy 8, no. 4 (2021): 14–24. http://dx.doi.org/10.14338/ijpt-21-00016.

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Abstract Purpose Long-term data regarding the disease control outcomes of proton beam therapy (PBT) for patients with favorable risk intact prostate cancer (PC) are limited. Herein, we report our institution's long-term disease control outcomes in PC patients with clinically localized disease who received PBT as primary treatment. Methods One hundred sixty-six favorable risk PC patients who received definitive PBT to the prostate gland at our institution from 2010 to 2012 were retrospectively assessed. The outcomes studied were biochemical failure-free survival (BFFS), biochemical failure, loc

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Kundu, Palak, Alan Lee, Alexandra Drakaki, et al. "Safety lead-in of phase II SBRT and durvalumab with or without tremelimumab for unresectable and cisplatin-ineligible, locally advanced or metastatic bladder cancer." Journal of Clinical Oncology 40, no. 6_suppl (2022): 517. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.517.

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517 Background: Many patients with muscle-invasive bladder cancer are not ideal candidates for chemotherapy or radical cystectomy. Moreover, local progression may further impair quality of life. Bladder preservation with maximal transurethral resection of bladder tumor (TURBT) and stereotactic body radiotherapy (SBRT) is a viable treatment option for such patients, offering durable local control while potentiating the effect of immunotherapy. Herein, we report on the safety profile of SBRT in combination with durvalumab (anti-PDL1) and tremelimumab (anti-CTLA4) in the safety lead-in cohort of

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Villegas Mejia, Carlos Raul, Jose Arnoby Chacon Cardona, and Tomas Sanchez Villegas. "Anal cancer in Oncólogos del Occidente from Colombia, South America 1997-2012." Journal of Clinical Oncology 31, no. 15_suppl (2013): e15189-e15189. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15189.

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e15189 Background: This work describes epidemiologic characteristics in anal cancer, in the United States is 1% to 2% of bowel cancers and 3.9% of anorectal carcinomas. Statistics for anal cancer are unknown in our specific Colombia region. Methods: We performed a descriptive preliminary retrospective analysis of 50% of our total patients from Oncologos del Occidente like a private treatment cancer center from January of 1997 to June 2012. Results: 10,000 records were reviewed with 663 colorectoanal cancer and 47 were anal cancer; median age 60.064 (range 32-88. SD. 12.595), 64% female and 96%

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MITROFANOV, MIKHAIL V., ALEXANDER M. KRIBEL, ALEXEY S. FROLENKOV, and OLEG L. SPITSYN. "THE METHOD OF DETECTING ATTACKS, SUCH AS SQL-INJECTION BASED ON ARTIFICIAL INTELLIGENCE ALGORITHMS, BY THE METHOD OF THE CLASSIFICATION PROBLEM." H&ES Research 13, no. 5 (2021): 96–102. http://dx.doi.org/10.36724/2409-5419-2021-13-5-96-102.

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Introduction: computerization of the vital activity system of modern society is gaining more and more large-scale boundaries every day. In this regard, the risk of loss and theft of confidential information in various ways, including through various attacks, also increases. Purpose: the aim of the study is to develop an optimal method for detecting attacks, using the example of SQL-Injection attacks, based on a given algorithm of artificial intelligence. Methods: a training system for artificial intelligence based on a given algorithm of artificial intelligence is proposed Results: as a result

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Suckling, David Maxwell, Mary Claire Levy, Gerardo Roselli, et al. "Live Traps for Adult Brown Marmorated Stink Bugs." Insects 10, no. 11 (2019): 376. http://dx.doi.org/10.3390/insects10110376.

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Surveillance for detection of the brown marmorated stink bug, Halyomorpha halys, is reliant on sticky panels with aggregation pheromone, which are low cost, but very inefficient (est. 3%). Trapping for adults was conducted in Italy with novel live (or lethal) traps consisting of aggregation pheromone-baited cylinders with a wind vane, with the upwind end covered by mesh and the downwind end sealed by a removable entry-only mesh cone, admitting the attracted bugs. The novel traps caught up to 15-times more adult H. halys than identically-baited sticky panels in two weeks of daily checking (n =

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Vanderlei, Renato Soares, Maria Fabíola Barros, Arthur Domingos-Melo, Gilberto Dias Alves, Ana Beatriz Silva, and Marcelo Tabarelli. "Extensive clonal propagation and resprouting drive the regeneration of a Brazilian dry forest." Journal of Tropical Ecology 37, no. 1 (2021): 35–42. http://dx.doi.org/10.1017/s0266467421000079.

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AbstractWoody plant resprouting has received considerable attention in the last two decades as human disturbances continue to encroach on terrestrial ecosystems globally. We examined the regeneration mechanisms of a Caatinga dry forest in the context of slash-and-burn agriculture and resprouting ability of the local flora. We excavated two old fields (from 32) experiencing early forest regeneration dominated by the tree Pityrocarpa moniliformis (Fabaceae) to map clonal propagation and, in parallel, submitted 260 seedlings from 13 woody plant species to experimental clipping. What seemed to be

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Suprapto, Hadi, Yunita Nita, and Andi Hermansyah. "Assessment of pharmaceutical inventory management in an Indonesian district health office: A pioneer study during the Covid-19 pandemic." Pharmacy Education 23, no. 4 (2023): 164–67. http://dx.doi.org/10.46542/pe.2023.234.164167.

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Background: Pharmaceutical inventory management (PIM) is important for efficient budgeting and cost control of medicines. This is particularly critical for local health offices in Indonesia, especially during the Covid-19 pandemic. Objective: To assess the PIM in the Gunungkidul health office in Indonesia. Method: A cross-sectional descriptive study evaluating inventory data was conducted between January and May 2022. Data obtained from 2019 to 2021 were triangulated with other data from the Ministry of Health and public health centres in Gunungkidul. Results: The availability of medicine item

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Myszkowska, Dorota, Katarzyna Piotrowicz, Monika Ziemianin, et al. "Unusually high birch (Betula spp.) pollen concentrations in Poland in 2016 related to long-range transport (LRT) and the regional pollen occurrence." Aerobiologia 37, no. 3 (2021): 543–59. http://dx.doi.org/10.1007/s10453-021-09703-w.

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Abstract In 2016, the highest birch (Betula spp.) pollen concentrations were recorded in Kraków (Poland) since the beginning of pollen observations in 1991. The aim of this study was to ascertain the reason for this phenomenon, taking the local sources of pollen in Poland and long-range transport (LRT) episodes associated with the pollen influx from other European countries into account. Three periods of higher pollen concentrations in Kraków in 2016 were investigated with the use of pollen data, phenological data, meteorological data and the HYSPLIT numerical model to calculate trajectories u

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