Academic literature on the topic '3BP2'

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Journal articles on the topic "3BP2"

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Deckert, Marcel. "L’adaptateur 3BP2." médecine/sciences 22, no. 12 (2006): 1081–86. http://dx.doi.org/10.1051/medsci/200622121081.

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Foucault, Isabelle, Séverine Le Bras, Céline Charvet, Chéol Moon, Amnon Altman, and Marcel Deckert. "The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor." Blood 105, no. 3 (2005): 1106–13. http://dx.doi.org/10.1182/blood-2003-08-2965.

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Abstract Engagement of the B-cell antigen receptor (BCR) activates kinases of the Src and Syk families and signaling complexes assembled by adaptor proteins, which dictate B-cell fate and function. The adaptor 3BP2/SH3BP2, an Abl Src homology domain 3 (SH3)–binding and Syk-kinases interacting protein, exhibits positive regulatory roles in T, natural killer (NK), and basophilic cells. However, its involvement in BCR signaling is completely unknown. Here we show that 3BP2 is tyrosine phosphorylated following BCR aggregation on B lymphoma cells, and that 3BP2 is a substrate for Syk and Fyn, but n
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Sada, Kiyonao, S. M. Shahjahan Miah, Koichiro Maeno, Shinkou Kyo, Xiujuan Qu та Hirohei Yamamura. "Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". Blood 100, № 6 (2002): 2138–44. http://dx.doi.org/10.1182/blood-2001-12-0340.

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Abstract Aggregation of high-affinity IgE receptor FcεRI induces sequential activation of nonreceptor-type protein-tyrosine kinases and subsequent tyrosine phosphorylation of cellular proteins, leading to degranulation in mast cells. A hematopoietic cell–specific adaptor protein, 3BP2, that was originally identified as an Abl SH3-binding protein was rapidly tyrosine phosphorylated by the aggregation of FcεRI on rat basophilic leukemia RBL-2H3 cells. Tyrosine phosphorylation of 3BP2 did not depend on calcium influx from external sources. To examine the role of 3BP2 in mast cells, we overexpress
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de la Fuente, Miguel A., Lalit Kumar, Bao Lu, and Raif S. Geha. "3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation." Molecular and Cellular Biology 26, no. 14 (2006): 5214–25. http://dx.doi.org/10.1128/mcb.00087-06.

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ABSTRACT The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2−/− mice. 3BP2−/− mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the
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Sada, Kiyonao, and Tomoko Hatani. "Adaptor Protein 3BP2 and Cherubism." Current Medicinal Chemistry 15, no. 6 (2008): 549–54. http://dx.doi.org/10.2174/092986708783769795.

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Yu, Zhenbao, Meryem Maoui, Zhizhuang J. Zhao, Yang Li, and Shi-Hsiang Shen. "SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling." FEBS Journal 273, no. 10 (2006): 2195–205. http://dx.doi.org/10.1111/j.1742-4658.2006.05233.x.

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Chen, Grace, Ioannis D. Dimitriou, Jose La Rose, et al. "The 3BP2 Adapter Protein Is Required for Optimal B-Cell Activation and Thymus-Independent Type 2 Humoral Response." Molecular and Cellular Biology 27, no. 8 (2007): 3109–22. http://dx.doi.org/10.1128/mcb.01014-06.

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ABSTRACT 3BP2 is a pleckstrin homology domain- and Src homology 2 (SH2) domain-containing adapter protein that is mutated in the rare human bone disorder cherubism and which has also been implicated in immunoreceptor signaling. However, a function for this protein has yet to be established. Here we show that mice lacking 3BP2 exhibited a perturbation in the peritoneal B1 and splenic marginal-zone B-cell compartments and diminished thymus-independent type 2 antigen response. 3BP2−/− B cells demonstrated a proliferation defect in response to antigen receptor cross-linking and a heightened sensit
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Chen, Grace, Ioannis Dimitriou, Laura Milne, et al. "The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation." Journal of Immunology 189, no. 5 (2012): 2138–50. http://dx.doi.org/10.4049/jimmunol.1103184.

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Jevremovic, Dragan, Daniel D. Billadeau, Renee A. Schoon, Christopher J. Dick, and Paul J. Leibson. "Regulation of NK Cell-Mediated Cytotoxicity by the Adaptor Protein 3BP2." Journal of Immunology 166, no. 12 (2001): 7219–28. http://dx.doi.org/10.4049/jimmunol.166.12.7219.

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Levaot, Noam, Paul D. Simoncic, Ioannis D. Dimitriou, et al. "3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions." Journal of Clinical Investigation 121, no. 8 (2011): 3244–57. http://dx.doi.org/10.1172/jci45843.

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Dissertations / Theses on the topic "3BP2"

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Moon, Cheol. "Rôle de l'adaptateur 3BP2 SH3BP2 dans l'activation des lymphocytes." Nice, 2007. http://www.theses.fr/2007NICE4017.

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Lymphocyte antigen receptor engagement triggers activation of various signaling cascades, initiated by sequential activation of the Src and Syk families of protein tyrosine kinases, and leading to gene transcription. Although they lack both enzymatic and transcriptional activity, adaptor proteins are crucial for this process. The cytoplasmic adaptor protein 3BP2 contains a PH domain, proline–rich regions, and a SH2 domain, and interacts with Syk kinases, the LAT adaptor and the PLCg. 3BP2 plays a positive role in NK cytotoxicity, in basophilic degranulation, and activation of NFAT and AP-1 tra
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Guezguez, Amel. "Rôle de la protéine adaptatrice 3BP2/SH3BP2 dans la régulation de l'homéostasie osseuse." Nice, 2011. http://www.theses.fr/2009NICE4121.

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Les ostéoclastes sont des cellules multinucléées capables de résorber le tissu osseux, elles se différencient à partir de la lignée hématopoïétique en présence de Receptor Activator of Nuclear Factor NF-kB (RANK-L) et M-CSF (Macrophage-Colony Stimulating Factor). Les récepteurs RANK et M-CSFR relaient et amplifient le signal de leurs ligands en activant de multiples voies de signalisation intracellulaire dont l’intégration aboutira à l’intégration de NFATc1, facteur de transcription essentiel pour la différenciation des ostéoclastes. Les protéines adaptatrices, du fait de leur structure, jouen
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Saborit, Villarroya Ifigènia. "Paper de la molècula adaptadora 3BP2 en la senyalització dels receptors leucocitaris de la família del CD150." Doctoral thesis, Universitat de Barcelona, 2006. http://hdl.handle.net/10803/879.

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La família del CD150, està formada per receptors de la superfamília de les immunoglobulines, expressats en la membrana de cèl·lules del sistema immune. Es caracteritzen per compartir una elevada homologia estructural i localitzar en la mateixa posició 23 del braç llarg del cromosoma 1. Els membres de la família CD84, CD150, CD229, CD244, CD319 i NTB-A presenten una regió intracel·lular amb, com a mínim, un motiu tirosina del tipus T-V/I-Y-XX-V/I. Aquest és el motiu consens d'unió d'una família de molècules adaptadores anomenades SAP i EAT-2. En humans, deficiències en SAP, són responsables d'u
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Ainsua, Enrich Erola. "La proteïna adaptadora 3BP2 com a regulador de l’activitat cel·lular a través dels receptors de membrana FcεRI i KIT". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/310213.

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Les molècules adaptadores són essencials en l'organització de les molècules de senyalització i en la coordinació i compartimentació de la seva activitat . 3BP2 és una proteïna adaptadora citoplasmàtica expressada ubiqüament però principalment en cèl·lules hematopoètiques. S'ha demostrat que actua com un regulador positiu transduïnt la senyal cel·lular en cèl·lules T , B i NK. 3BP2 és un important regulador en l’alliberació de grànuls citotòxics en les cèl·lules NK. Els mastòcits es desgranulen de manera similar després de l'agregació depenent d'antigen de l'alta afinitat del receptor per IgE (
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Ainsua, Enrich Erola. "La proteïna adaptadora 3BP2 com a regulador de l’activitat cel.lular a través dels receptors de membrana FcεRI i KIT". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/310213.

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Les molècules adaptadores són essencials en l'organització de les molècules de senyalització i en la coordinació i compartimentació de la seva activitat . 3BP2 és una proteïna adaptadora citoplasmàtica expressada ubiqüament però principalment en cèl·lules hematopoètiques. S'ha demostrat que actua com un regulador positiu transduïnt la senyal cel·lular en cèl·lules T , B i NK. 3BP2 és un important regulador en l’alliberació de grànuls citotòxics en les cèl·lules NK. Els mastòcits es desgranulen de manera similar després de l'agregació depenent d'antigen de l'alta afinitat del receptor per IgE (
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Bernardi, Ewerthon Cezar Schiavo. "QUALIDADE DAS ESTIMATIVAS DE PRECIPITAÇÃO DO SATÉLITE TRMM NO ESTADO DO RIO GRANDE DO SUL." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/7658.

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Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul<br>Understanding the spatial and temporal rainfall occurrence, improves the water resources management, both in order to prevent losses related to the occurrence of floods and droughts events, as in relation to the supply of the various sectors. Thus, satellite rainfall estimates are an alternative to obtain representative data of large areas, since the gauge data from meteorological stations are scarce, frequently due the low density of stations per area. However, these satellite products contain uncertainties when compared to gauge
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Grozdanov, Saso. "Hydrodynamics : from effective field theory to holography." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c00bd3e6-3b52-41d5-8542-2f2d55fc8741.

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Hydrodynamics is an effective theory that is extremely successful in describing a wide range of physical phenomena in liquids, gases and plasmas. However, our understanding of the structure of the theory, its microscopic origins and its behaviour at strong coupling is far from complete. To understand how an effective theory of dissipative hydrodynamics could emerge from a closed microscopic system, we analyse the structure of effective Schwinger-Keldysh Closed-Time-Path theories. We use this structure and the action principle for open systems to derive the energy-momentum balance equation for
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Wallis, Stephanie. "Investigating the pathogenesis of tau protein in stem cell models of neurodegenerative disease." Thesis, University of Bristol, 2018. http://hdl.handle.net/1983/a33b1dd1-3bf2-4865-99b8-b44b4ac09a8e.

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Tauopathies are neurodegenerative diseases characterised by the pathological phosphorylation and accumulation of tau protein within the brain. Despite considerable efforts, the molecular pathways underlying tau pathogenesis have not yet been fully elucidated. This has been partially attributed to the limitations of traditionally used in vitro and in vivo models to recapitulate the complex molecular pathways involved in the pathogenesis of tau. The use of human induced pluripotent stem cell (hiPSC) technology has enabled the derivation of disease-relevant cell types from patients with tauopathy
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Michot, Véronique. "Analyse spatiale et temporelle de la variabilité des régimes de précipitations dans le bassin amazonien." Thesis, Rennes 2, 2017. http://www.theses.fr/2017REN20050/document.

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Dans la zone intertropicale, les précipitations sont le principal marqueur climatique saisonnier et déterminent très largement l’hydrologie de surface et de nombreuses activités anthropiques. Le bassin amazonien est caractérisé par divers régimes régionaux de précipitations, dont la variabilité spatiale et temporelle est forte. De nombreux travaux ont montré que cette variabilité est liée à des forçages externes de large échelle, comme les températures de surface de l’océan. L’étude des précipitations dans cette région porte le plus souvent sur les tendances ou les extrêmes pluviométriques. En
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Brown, Richard Matthew. "Coherent transfer between electron and nuclear spin qubits and their decoherence properties." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:21e043b7-3b72-44d7-8095-74308a6827dd.

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Conventional computing faces a huge technical challenge as traditional transistors will soon reach their size limitations. This will halt progress in reaching faster processing speeds and to overcome this problem, require an entirely new approach. Quantum computing (QC) is a natural solution offering a route to miniaturisation by, for example, storing information in electron or nuclear spin states, whilst harnessing the power of quantum physics to perform certain calculations exponentially faster than its classical counterpart. However, QCs face many difficulties, such as, protecting the quantum-
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Books on the topic "3BP2"

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Reinhart, Brandon R. Role of adaptor protein 3BP2 in B cell survival and homeostasis. 2004.

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3BP-2: A novel substrate of the FLT3 receptor tyrosine kinase. National Library of Canada, 1996.

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American Telephone and Telegraph Company. At&t Computer Software Catalog: Unix System V Software for the At&t 3B2/3B5/3B20 and Unix Pc/Winter 1986 (At & T Computer Software Catalog Unix System ... for the at & T 3b2/3b5/3b20 and Unix PC). Natl Book Network, 1986.

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American Telephone and Telegraph Company., ed. UNIX System V: Manuel de référence de l'utilisateur. Masson, 1987.

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AT&T computer software catalog: UNIX system V software for the AT&T 3B2/3B5/3B20 and UNIX PC :Winter 1986. Prentice-Hall, 1986.

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Book chapters on the topic "3BP2"

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Holze, Rudolf. "Ionic conductance of Te2(C5H10)3Br2." In Electrochemistry. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49251-2_1524.

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Hadria, Rachid, Adil Salhi, Tarik Benabdelouahab, et al. "Evaluation of TRMM 3B42 V7 Rainfall Product in Morocco." In Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition). Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51210-1_298.

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Dinku, Tufa, Stephen J. Connor, and Pietro Ceccato. "Comparison of CMORPH and TRMM-3B42 over Mountainous Regions of Africa and South America." In Satellite Rainfall Applications for Surface Hydrology. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2915-7_11.

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Athreya, K. S., and R. N. Shelton. "Evidence for Spin Fluctuations in the Mixed Valent Superconductors Ce(Ru1-xOsx)3B2." In Theoretical and Experimental Aspects of Valence Fluctuations and Heavy Fermions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0947-5_71.

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Cicchetti, Piera, and David Baltimore. "[17] Identification of 3BP-1 in cDNA expression library by SH3 domain screening." In Small GTPases and Their Regulators Part B: Rho Family. Elsevier, 1995. http://dx.doi.org/10.1016/0076-6879(95)56019-x.

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Conference papers on the topic "3BP2"

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Goldman, M., K. Pangal, G. Naso, and A. Goda. "25nm 64Gb 130mm² 3bpc NAND Flash Memory." In 2011 3rd IEEE International Memory Workshop (IMW). IEEE, 2011. http://dx.doi.org/10.1109/imw.2011.5873197.

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Laurent, Linguet, Pierre Audois, Isabelle Marie-Joseph, Melanie Becker, and Frederique Seyler. "Calibration of TRMM 3B42 with Geographical Differential Analysis over North Amazonia." In IGARSS 2013 - 2013 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2013. http://dx.doi.org/10.1109/igarss.2013.6723261.

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Kazamias, Anastasios-Petros, Marios Sapountzis, and Kostas Lagouvardos. "Evaluation and intercomparison of GPM-IMERG and TRMM 3B42 daily precipitation products over Greece." In Fifth International Conference on Remote Sensing and Geoinformation of the Environment (RSCy2017), edited by Giorgos Papadavid, Diofantos G. Hadjimitsis, Silas Michaelides, Vincent Ambrosia, Kyriacos Themistocleous, and Gunter Schreier. SPIE, 2017. http://dx.doi.org/10.1117/12.2279689.

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Hongfen, Teng, Tian Yanfeng, Shi Zhou, and Jin Huiming. "Spatial-temporal accuracy validation and uncertainty analysis for TRMM 3B42 data at provincial scale in China." In 2012 First International Conference on Agro-Geoinformatics. IEEE, 2012. http://dx.doi.org/10.1109/agro-geoinformatics.2012.6311705.

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Liangfeng, Wang, Xiang Kangshen, Mao Luqin, Tong Hang, and Qiao Weiyang. "Numerical Simulation of the Effect of the Tip Clearance Flow on Rotor-Stator Interaction Tone Noise in Axial-Flow Fan." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-14179.

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Abstract The present study is focused on the sound generation due to the rotor tip clearance flow interaction with stator in an axial flow fan. A hybrid URANS/Goldstein’s equations method is applied to calculate the unsteady flow and tone noise in a high loaded axial-flow fan with different rotor tip clearance. The numerical simulation results show that the main sound sources of fan tip clearance tone noise are concentrated in the leading edge of downstream stator blades. It is found that when the rotor tip clearance increases from zero to 2.5 mm (0.94% relative blade height), the mass flow of
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Seo, Seock No, and Eung Soo Kim. "Dielectric properties of rutile (Zn1/3B2/3)x(TiySn1-y)1-xO2 (B=Nb5+,Ta5+) at microwave frequency." In 2009 18th IEEE International Symposium on the Applications of Ferroelectrics (ISAF). IEEE, 2009. http://dx.doi.org/10.1109/isaf.2009.5307563.

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