Relevant bibliographies by topics / 3D culture model

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  1. Dissertations / Theses

Academic literature on the topic '3D culture model'

Author: Grafiati
Published: 14 March 2023
Last updated: 25 May 2024

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Dissertations / Theses on the topic "3D culture model"

1

Zhao, Huizhi. "3D Cell Culture Model Synthesized By Polycaprolactone Nanofiber Electrospinning." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1531319675295094.

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Peddagangannagari, Sreekanth Reddy. "An in vitro human 3D co-culture model to study endothelial-astrocyte interactions." Thesis, Open University, 2012. http://oro.open.ac.uk/54831/.

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At the gliovascular interface, reciprocal inductive influences between brain microvascular endothelial cells (BMVEC) and astrocytes occur. Most of the knowledge in this area of research is derived from in vitro eo-culture models in which astrocytes are cultured on a stiff, two-dimensional (2D) surface. Three-dimensional (3D) culture models closely mimic the in lJZVO cellular architecture and they bridge the gap between 2D culture models and animal models. Hence, an in vitro 3D eo-culture model was developed and characterised, to study the interactions between BMVEC and astrocytes. In this mode
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Smith, Jenny Thompson. "A 3D culture model to investigate cellular responses to mechanical loading in spinal cord injury." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16199/.

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Spinal cord injury (SCI) can cause paralysis, loss of sensation, and respiratory dependency, which has a significant impact on the quality of life of patients, their life expectancy and is also a significant economic burden due to the high costs associated with primary care and loss of income. One of the difficulties in establishing a treatment method is the heterogeneity of SCI; there are many different types and severities of traumatic primary injury, across different age groups of patients and different locations within the spinal cord, whilst at a cellular level, there are multiple, intera
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Manzan, Martins Camilla. "EFFECT OF ENDOCRINE DISRUPTORS ON HUMAN ENDOMETRIAL STROMAL CELLS AND THEIR INTERACTION WITH TROPHOBLAST." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1183943.

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Decidualization is crucial for embryo development and implantation, placenta formation and fetal growth. This process is characterized by morphological and biological changes in endometrial stromal cells that play a key role on fetal trophoblast migration and invasion. Successful placentation depends on the interaction between endometrial stromal cells and extravillous trophoblast cells. The trophoblast spheroids, a 3D culture model, is reported to appropriately mimic the in vivo situation, and reflect the cell to cell interaction. The Bisphenol A (BPA) and para-nonylphenol (p-NP) are endocri
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Sieh, Shirly. "Development of a 3D culture system to study the skeletal metastasis of prostate cancer." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/50870/1/Shirly_Sieh_Thesis.pdf.

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In the cancer research field, most in vitro studies still rely on two-dimensional (2D) cultures. However, the trend is rapidly shifting towards using a three-dimensional (3D) culture system. This is because 3D models better recapitulate the microenvironment of cells, and therefore, yield cellular and molecular responses that more accurately describe the pathophysiology of cancer. By adopting technology platforms established by the tissue engineering discipline, it is now possible to grow cancer cells in extracellular matrix (ECM)-like environments and dictate the biophysical and biochemical pr
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Vazquez, Marisol. "Development of a novel in vitro 3D osteocyte-osteoblast co-culture model to investigate mechanically-induced signalling." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/56764/.

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Normal mechanical loading potently induces bone formation mediated by osteocyte effects on osteoblasts. Current in vitro bone models do not reflect these cellular interactions, either focusing on mechanical loading of osteoblasts in monolayers or in 3D and therefore not elucidating the osteocyte-osteoblast interactions that regulate mechanically-induced bone formation. Adenosine, calcium-sensing and glutamate signalling have been shown to influence bone biology, with both adenosine precursors and glutamate having been implicated in mechanotransduction. The aims were to develop a novel in vitro
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7

Smolina, Margarita. "Breast cancer cell lines grown in a three-dimensional culture model: a step towards tissue-like phenotypes as assessed by FTIR imaging." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/267686.

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Despite the possible common histopathological features at diagnosis, cancer cells present within breast carcinomas are highly heterogeneous in their molecular signatures. This heterogeneity is responsible for disparate clinical behaviors, treatment responses and long-term outcomes in breast cancer patients. Although the few histopathological markers can partially describe the diversity of cells found in tumor tissue sections, the full molecular characterization of individual cancer cells is currently impossible in routine clinical practice. In this respect, Fourier transform infrared (FTIR) mi
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Sorrentino, Rita. "Three dimensional oral mucosa models: development and applications." Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/114910.

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Animal experimentation has been extensively and for a long time applied in several research fields, but since 2011 it has been substantially limited by the Commission of the European Parliament to ensure people/animals safety and reduce research costs. To respond to these directives, many attempts have been focused on the development and validation of new in vitro 3D systems, bypassing the traditional 2D cell cultures. In this regard, diverse approaches to tissue-engineered bone and oral mucosa have been developed. Despite the promising premises and the cutting-edge results, the used 3D in vit
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Cho, Hyung Joon. "Pro-oxidative and Pro-inflammatory Mechanisms of Brain Injury in Experimental Animal and 3D Cell Culture Model Systems." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73476.

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The pro-oxidative and pro-inflammatory mechanisms have been implicated in various human diseases including neurological and psychiatric disorders. However, there is only limited information available on the etiology in the progression of neurological damage to brain. The emergence of tissue engineering with the growing interest in mechanistic studies of brain injury now raises great opportunities to study complex physiological and pathophysiological process in vitro. Therefore, the prime goals of this study include: (1) Determination of the molecular and cellular mechanisms responsible for bla
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10

Lee, Si Yuen. "Culture of human pluripotent stem cells and neural networks in 3D using an optogenetic approach and a hydrogel model." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:5cecda23-6208-4c0f-a800-d5ddccae24d3.

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Development of optogenetically controllable human neural network models can provide an investigative system that is relevant to the human brain. Conventional cultures of neural networks in two-dimensions (2D) have major limitations of scale. For instance, the soma of neurons in 2D is unrealistically flattened and both axon and dendrite outgrowth is restricted. Using a combination of tissue engineering techniques and the inclusion of optogenetically modified human induced pluripotent stem cell (hiPSC)-derived neural progenitor cells (NPCs), the development of a three-dimensional (3D) human neur
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