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Relevant bibliographies by topics / 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (norepinephrine)

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Academic literature on the topic '4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (norepinephrine)'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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Journal articles on the topic "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (norepinephrine)"

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Milanović, Žiko, Dušan Dimić, Jasmina Dimitrić Marković, Marijana Stanojević-Pirković, Edina Avdović та Zoran Marković. "THE INTERACTION OF PROTONATED OCTOPAMINE AND NOREPINEPHRINE WITH Β1-ADRENERGIC RECEPTOR: MOLECULAR DOCKING AND DYNAMICAL SIMULATION". Journal of the Serbian Society for Computational Mechanics, Special (1 червня 2020): 13–25. http://dx.doi.org/10.24874/jsscm.2020.01.02.

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In the current study, the interaction mechanisms between protonated neurotransmitters: octopamine (4-(2-amino-1-hydroxyethyl)phenol) and norepinephrine (4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol) with the β-1 adrenergic receptor (β1AR) were examined by molecular docking, molecular dynamics (MD) simulations and MM/PBSA free energy calculations. The investigated receptor belongs to the G-protein coupled receptor group. The investigation was carried out at physiological pH=7.4. It was estimated that both compounds exist in the protonated form in the water at physiological pH. It was found t

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Wai, Sandra G., Paul J. Rozance, Stephanie R. Wesolowski, William W. Hay, and Laura D. Brown. "Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates." American Journal of Physiology-Endocrinology and Metabolism 315, no. 6 (2018): E1143—E1153. http://dx.doi.org/10.1152/ajpendo.00128.2018.

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Overcoming impaired growth in an intrauterine growth-restricted (IUGR) fetus has potential to improve neonatal morbidity, long-term growth, and metabolic health outcomes. The extent to which fetal anabolic capacity persists as the IUGR condition progresses is not known. We subjected fetal sheep to chronic placental insufficiency and tested whether prolonged amino acid infusion would increase protein accretion in these IUGR fetuses. IUGR fetal sheep were infused for 10 days with either mixed amino acids providing ~2 g·kg−1·day−1 (IUGR-AA) or saline (IUGR-Sal) during late gestation. At the end o

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Sturdivant, Jill, and Mitchell deLong. "Asymmetric Synthesis of Netarsudil: A New Therapeutic for Open-Angle Glaucoma." Synthesis 51, no. 04 (2018): 953–59. http://dx.doi.org/10.1055/s-0037-1610310.

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The asymmetric synthesis of a Rho kinase/norepinephrine transport inhibitor, netarsudil, the active component in the recently FDA-approved product Rhopressa™, is described herein. This concise six-step synthetic route utilizes the 2,4-dimethylbenzoate ester of a phenylacetic acid as the backbone of the β-amino acid’s framework. A chiral enolate of the Evans auxiliary, (R)-4-benzyloxazolidin-2-one, is used to direct the formation of the (S)-stereocenter by incorporating the N-Boc-protected β-amino methyl arm with high diastereoselectivity (96:4 dr) using N-Boc-1-aminomethylbenzotriazole as the

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Lin, Frank, Jaydira Del Rivero, Jorge A. Carrasquillo, et al. "Phase 2 trial of Lu-177-DOTATATE in inoperable pheochromocytoma/paraganglioma." Journal of Clinical Oncology 37, no. 15_suppl (2019): TPS4159. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps4159.

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TPS4159 Background: Pheochromocytoma/paraganglioma (PHEO/PGL) is a rare malignancy that arises from chromaffin cells of typically the adrenal medulla but can also be of extra-adrenal origin. These tumors produce excessive catecholamines such as epinephrine and norepinephrine which causes labile hypertension, tachycardia, and flushing. Lu-177-DOTATATE (Lu-177-dodecanetetraacetic acid‐tyrosine-3-octreotate) is a radiolabeled somatostatin analog that is FDA approved for somatostatin receptor-positive neuroendocrine tumors. It is being being investigated in PHEO/PGL, which overexpress somatostatin

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Al-Khafaji, Ali Jabbar Oleiwi. "The Effects of Extracted Peptide from Skin of Iraqi Frog (Rana ridibunda) on Human Leukemic Lymphocytes." Baghdad Science Journal 16, no. 1 (2019): 0040. http://dx.doi.org/10.21123/bsj.16.1.0040.

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The purified frog skin peptides were tested on leukemic patients lymphocytes, which revealed effects of cytotoxicity. Four frogs (Rana ridibunda) were stimulated by single intra-peritoneal injection of norepinephrine-HCl . Five different peptides;1(18) A, 2(19) L, 3(20) I,4(21) E and 5(22) Y were isolated and quantified. The peptide 3(20)I had 5.87% of hemolysis, while healthy human lymphocytes cytotoxic activity was for 2(19)L with inhibition( -10.4%).All peptides were subjected to polyacrylamide gel electrophoresis. The results revealed peptides 1(18)A, 2(19)L, 3(20)I which appeared as low a

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Borda, Tania Gabriela, Graciela Cremaschi та Leonor Sterin-Borda. "Haloperidol-mediated phosphoinositide hydrolysis via direct activation of α1-adrenoceptors in frontal cerebral rat cortex". Canadian Journal of Physiology and Pharmacology 77, № 1 (1999): 22–28. http://dx.doi.org/10.1139/y98-153.

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In addition to its effect on D2 dopamine receptor blockades, haloperidol is able to interact with multiple neurotransmitters (NTs). Its action on phosphoinositide (PI) turnover was studied on cerebral cortex preparations. It induces an increase in inositol phosphate (IP) accumulation, which was only blunted by the α1-adrenoceptor blocker prazosin. Haloperidol maximal effect (Emax) was less than the effect of the full agonist norepinephrine (NE), and dose-response curves for both NE in the presence of submaximal doses of haloperidol and haloperidol in the presence of Emax doses of NE showed tha

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Katakura, N., and S. H. Chandler. "An iontophoretic analysis of the pharmacologic mechanisms responsible for trigeminal motoneuronal discharge during masticatory-like activity in the guinea pig." Journal of Neurophysiology 63, no. 2 (1990): 356–69. http://dx.doi.org/10.1152/jn.1990.63.2.356.

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1. The effects of iontophoretic application of the excitatory amino acid antagonists kynurenic acid (KYN) and DL-2-amino-5-phosphonovaleric acid (APV), as well as the monoamines serotonin (5-HT) and norepinephrine (NE), on extracellularly recorded jaw opener motoneuron [digastric motoneuron (DIG)] discharge during cortically induced rhythmical masticatory-like activity (RMA) were examined in the anesthetized guinea pig. 2. Iontophoretic application of KYN, a broad-spectrum amino acid antagonist, suppressed the motoneuronal discharge evoked by short pulse train stimulation of the cortex for mos

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Pung, Thitiya, Bradley Klein, Dennis Blodgett, Bernard Jortner, and Marion Ehrich. "Examination of Concurrent Exposure to Repeated Stress and Chlorpyrifos on Cholinergic, Glutamatergic, and Monoamine Neurotransmitter Systems in Rat Forebrain Regions." International Journal of Toxicology 25, no. 1 (2006): 65–80. http://dx.doi.org/10.1080/10915810500527119.

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Repeated stress has been reported to cause reversible impairment in the central nervous system (CNS). It was proposed that alterations in glutamatergic, cholinergic, and monoamine neurotransmitter systems after exposure to stress are initial CNS events contributing to this impairment and that exacerbation could occur with concurrent exposure to cholinesterase inhibitors. Effects of concurrent exposure to repeated stress and chlorpyrifos on activities of acetylcholinesterase (AChE), carboxylesterase, and choline acetyltransferase (ChAT); concentrations of excitatory amino acids, monoamines, and

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Zhang, Bin, Xiaorong Li, Chu Chen, et al. "Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy." Cellular Physiology and Biochemistry 46, no. 6 (2018): 2471–79. http://dx.doi.org/10.1159/000489653.

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Background/Aims: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. Methods: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague–Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Sham-MI and sham-RDN rats served as the control group. At 4 weeks after RDN, programmed electrical stimulation (PES) was used to induce VAs, including ventricular tachycardia and ventricular fibrillation, in all 3 groups (MI+RDN, MI, and control gro

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Wright, G. L., B. S. Huang, P. J. Johnson, and W. D. McCumbee. "Hypertensive factor: calcium stimulatory activity obtained from different tissues and animal species." Canadian Journal of Physiology and Pharmacology 66, no. 10 (1988): 1278–81. http://dx.doi.org/10.1139/y88-209.

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It was recently shown that a peptide (hypertensive factor, HF) isolated from erythrocyte hemolysates from spontaneously hypertensive rats induced a prolonged elevation of blood pressure in normotensive rats. In addition, the peptide produced a marked stimulation of the in vitro uptake of lanthanum-resistant calcium by the aortae and enhanced the contractile response of aortic rings to constrictor agents. The present report describes findings of calcium stimulatory activity, enhancement of contractile function, or pressor activity in extracts of homogenates from several tissues of the rat and f

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Dissertations / Theses on the topic "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (norepinephrine)"

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(7360475), Sabyasachy Mistry. "MASS SPECTROMETRIC DETECTION OF INDOPHENOLS FROM THE GIBBS REACTION FOR PHENOLS ANALYSIS." Thesis, 2020.

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<p><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>ABSTRACT</a></p> <p>Phenols are ubiquitous in our surroundings including biological molecules such as L-Dopa metabolites, food components, such as whiskey and liquid smoke, etc. This dissertation describes a new method for detecting phenols, by reaction with Gibbs reagent to form indophenols, followed by mass spectrometric detection. Unlike the standard Gibbs reaction which uses a colorimetric approach, the use of mass spectrometry allows for simultaneous detection of differently substituted phenols. The procedure is

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Book chapters on the topic "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (norepinephrine)"

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Winkelmann, Jochen. "Diffusion coefficient of 4-(2-amino-1-hydroxyethyl)-benzene-1,2-diol in water." In Diffusion in Gases, Liquids and Electrolytes. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_640.

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