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Journal articles on the topic '4,5-dihydroisoxazole'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Pir, Meryem, Fatma Budak, and Kemal Metiner. "Determination of in vitro antifungal activity of dihydroisoxazole dimethanol compound against dermatophytes obtained from clinical isolates and design of some new dihydroisoxazole dimethanol compounds." International Journal of Chemistry and Technology 8, no. 1 (2024): 45–50. http://dx.doi.org/10.32571/ijct.1109476.

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In this study, the in vitro antifungal activity of (3-(4-chlorophenyl)-4,5-dihydroisoxazole-4,5-diyl) dimethanol compound (1) was investigated against two pathogenic fungi species (Trichophyton mentagrophytes and Microsporum canis) and important results were obtained. The difficulty of treating fungal diseases induced us to assess the antifungal properties of dihydroisoxazole dimethanol compound. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC). The compound (1) showed an antifungal effect with MIC=12.5 µg ml-1 on M. canis and MIC=50 µg ml-1 on T.

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2

Samshuddin, S., Ray J. Butcher, Mehmet Akkurt, B. Narayana, and H. S. Yathirajan. "3,5-Bis(4-methoxyphenyl)-4,5-dihydroisoxazole." Acta Crystallographica Section E Structure Reports Online 67, no. 8 (2011): o1975—o1976. http://dx.doi.org/10.1107/s1600536811026833.

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3

Sangale, Shital S., Priyanka S. Kale, Rachana B. Lamkane, Ganga S. Gore, Priyanka B. Parekar, and Shivraj S. Shivpuje. "Synthesis of Novel Isoxazole Derivatives as Analgesic Agents by Using Eddy’s Hot Plate Method." South Asian Research Journal of Pharmaceutical Sciences 5, no. 01 (2023): 18–27. http://dx.doi.org/10.36346/sarjps.2023.v05i01.002.

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The Isoxazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of Isoxazoles and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of Isoxazole from 4-methoxy aniline gives N-(4-methoxyphenyl) acetamide which was hydrolysis with sodium hydroxide and treated aromatic aldehydes yields resultant compound N-(4-methoxyphenyl) 3-phenyl propanamide (BSM-IIIA-IIIJ). Title compound were synthesized and the

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4

Barluenga, Joseé, Vicente Gotor, and María José Iglesias. "Synthesis of 4,5-dihydroisoxazole and isoxazolin-5-ones." Journal of Heterocyclic Chemistry 29, no. 7 (1992): 1717–19. http://dx.doi.org/10.1002/jhet.5570290707.

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5

Chopra, Deepak, T. P. Mohan, and B. Vishalakshi. "5-(4-Fluoro-3-phenoxyphenyl)-3-phenyl-4,5-dihydroisoxazole." Acta Crystallographica Section E Structure Reports Online 62, no. 9 (2006): o3819—o3820. http://dx.doi.org/10.1107/s1600536806030807.

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6

Jeddeloh, Melissa R., Jason B. Holden, Dustin H. Nouri, and Mark J. Kurth. "A Library of 3-Aryl-4,5-dihydroisoxazole-5-carboxamides." Journal of Combinatorial Chemistry 9, no. 6 (2007): 1041–45. http://dx.doi.org/10.1021/cc700117a.

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7

Thirunarayanan, G., and V. Sathiyendiran. "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles." International Letters of Chemistry, Physics and Astronomy 49 (April 2015): 1–14. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.49.1.

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Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radica

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8

Thirunarayanan, G., and V. Sathiyendiran. "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles." International Letters of Chemistry, Physics and Astronomy 49 (April 7, 2015): 1–14. http://dx.doi.org/10.56431/p-g0r04d.

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Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radica

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9

Fernández, Rosario, José Lassaletta, Abel Ros, Eleuterio Alvarez, and Hansjörg Dietrich. "A Practical Synthesis of Enantiopure 4,5-Dihydroisoxazole-5-carboxylic Acids." Synlett 2005, no. 19 (2005): 2899–904. http://dx.doi.org/10.1055/s-2005-921894.

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10

Chopra, Deepak, T. P. Mohan, and B. Vishalakshi. "5-(4-Fluoro-3-phenoxyphenyl)-3-(4-methylphenyl)-4,5-dihydroisoxazole." Acta Crystallographica Section E Structure Reports Online 62, no. 8 (2006): o3547—o3548. http://dx.doi.org/10.1107/s1600536806028406.

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11

BARLUENGA, J., V. GOTOR, and M. J. IGLESIAS. "ChemInform Abstract: Synthesis of 4,5-Dihydroisoxazole and Isoxazolin-5-ones." ChemInform 24, no. 21 (2010): no. http://dx.doi.org/10.1002/chin.199321162.

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12

Eşme, A., S. G. Sagdinc, and Y. S. Kara. "Experimental and theoretical study of the substituent type and position effects on 3-(substituted phenyl)-cis-4,5-dihydroisoxazole- 4,5-diyl)bismethylene)diacetate derivatives." Журнал структурной химии 62, no. 6 (2021): 934–44. http://dx.doi.org/10.26902/jsc_id72862.

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Effects of the substituent type and the position (X = -H, -p-CH3, -p-C2H5, -p-CF3, -p-Br, -p-Cl, -p-CN, -m-F, -m-NO2) on 3-(substituted phenyl)-cis-4,5-dihydroisoxazole-4,5-diyl)bis(methylene)diacetate derivatives are investigated experimentally FTIR and UV-Vis and theoretically using the density functional theory (DFT) at the B3LYP/6-311G(d,p) level of theory. The influence of these substituents on the frontier molecular orbital analysis of the investigated series is discussed using DFT. The absorption spectra (UV-Vis spectra) of all the derivatives in the gas phase and the chloroform solven

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13

de Andrade Danin Barbosa, Gabriela, Alcino Palermo de Aguiar, Erika Martins de Carvalho, and Joseli Maria da Rocha Nogueira. "Synthesis of 3-furanyl-4,5-dihydroisoxazole Derivatives via Cycloaddition and their Antibacterial Evaluation." Letters in Drug Design & Discovery 16, no. 3 (2019): 364–69. http://dx.doi.org/10.2174/1570180815666180627115606.

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Background: Antimicrobial resistance is a major threat to human health. So this manuscript describes the synthesis of five different 3,5-disubstituted 4,5-dihydroisoxazoles with antimicrobial activity. </P><P> Methods: They were obtained from nitrile oxide cycloaddition derived from 2-furaldehyde and 5- nitro-2-furaldehyde to different dipolarophiles (acrylamide, ethyl acrylate and styrene). All heterocycles were isolated (30-50 %) and characterized by FTIR, MS, 1H and 13C NMR, as they were also evaluated against Gram-positive and Gram-negative bacteria. </P><P> Results

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14

Sandhya, R., M. Sithambaresan, S. Prathapan, and M. R. Prathapachandra Kurup. "(2-tert-Butyl-3-phenyl-2,3-dihydroisoxazole-4,5-diyl)bis(phenylmethanone)." Acta Crystallographica Section E Structure Reports Online 69, no. 8 (2013): o1284—o1285. http://dx.doi.org/10.1107/s1600536813019508.

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15

Jeyabharathi, A., M. N. Ponnuswamy, S. Manikandan, and R. Raghunathan. "Spiro[3,4-bis(4-chlorophenyl)-4,5-dihydroisoxazole-5,3′-flavan-4′-one]." Acta Crystallographica Section E Structure Reports Online 59, no. 2 (2003): o237—o239. http://dx.doi.org/10.1107/s1600536803001387.

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16

Lombardo, Giuseppe M., Antonio Rescifina, Ugo Chiacchio, Alessia Bacchi та Francesco Punzo. "A top–down approach to crystal engineering of a racemic Δ2-isoxazoline". Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 70, № 1 (2014): 172–80. http://dx.doi.org/10.1107/s2052520613030862.

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The crystal structure of racemic dimethyl (4RS,5RS)-3-(4-nitrophenyl)-4,5-dihydroisoxazole-4,5-dicarboxylate, C13H12N2O7, has been determined by single-crystal X-ray diffraction. By analysing the degree of growth of the morphologically important crystal faces, a ranking of the most relevant non-covalent interactions determining the crystal structure can be inferred. The morphological information is considered with an approach opposite to the conventional one: instead of searching inside the structure for the potential key interactions and using them to calculate the crystal habit, the observed

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17

Bruno, Giuseppe, Archimede Rotondo, Giovanni Grassi, Francesco Foti, Francesco Risitano, and Francesco Nicoló. "5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid." Acta Crystallographica Section C Crystal Structure Communications 60, no. 7 (2004): o496—o497. http://dx.doi.org/10.1107/s010827010401265x.

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18

鲁, 松春. "Research for Synthesizing of [3-(2-Nitro-6-Methyl) Phenyl]-4,5 Dihydroisoxazole." Advances in Analytical Chemistry 13, no. 01 (2023): 42–49. http://dx.doi.org/10.12677/aac.2023.131004.

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19

Sales, Eric S., Adailton J. Bortoluzzi, and Aloir A. Merlo. "Crystal structure of 5-(4-tert-butoxyphenyl)-3-(4-n-octyloxyphenyl)-4,5-dihydroisoxazole." Acta Crystallographica Section E Crystallographic Communications 75, no. 6 (2019): 896–99. http://dx.doi.org/10.1107/s2056989019007412.

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The molecule of the title compound, C27H37NO3, was prepared by [3 + 2] 1,3-dipolar cycloaddition of 4-n-octylphenylnitrile oxide and 4-tert-butoxystyrene, the latter compound being a very useful intermediate to the synthesis of liquid-crystalline materials. In the molecule, the benzene rings of the n-octyloxyphenyl and tert-butoxyphenyl groups form dihedral angles of 2.83 (7) and 85.49 (3)°, respectively, with the mean plane of the isoxazoline ring. In the crystal, molecules are linked by weak C—H...O hydrogen interactions into chains running parallel to the b axis.

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20

Jeyabharathi, A., M. N. Ponnuswamy, S. Manikandan, and R. Raghunathan. "Spiro[3-(4-chlorophenyl)-4-(4-methylphenyl)-4,5-dihydroisoxazole-5,3′-flavan-4′-one]." Acta Crystallographica Section E Structure Reports Online 59, no. 2 (2003): o240—o241. http://dx.doi.org/10.1107/s1600536803001399.

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21

Guama, Antonio, Alberto Brandi, Andrea Goti, and Francesco De Sarlo. "4,5-Dihydroisoxazole-5-spirocyclopropanes. Synthesis and thermolytic rearrangement to 5,6-dihydro-4-pyridones." Journal of the Chemical Society, Chemical Communications, no. 21 (1985): 1518. http://dx.doi.org/10.1039/c39850001518.

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22

Ďurina, Lukáš, Anna Ďurinová, František Trejtnar, et al. "Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation." Beilstein Journal of Organic Chemistry 17 (November 24, 2021): 2781–86. http://dx.doi.org/10.3762/bjoc.17.188.

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A new highly diastereoselective synthesis of the polyhydroxylated pyrrolidine alkaloid (±)-codonopsinol B and its N-nor-methyl analogue, starting from achiral materials, is presented. The strategy relies on the trans-stereoselective epoxidation of 2,3-dihydroisoxazole with in situ-generated DMDO, the syn-selective α-chelation-controlled addition of vinyl-MgBr/CeCl3 to the isoxazolidine-4,5-diol intermediate, and the substrate-directed epoxidation of the terminal double bond of the corresponding γ-amino-α,β-diol with aqueous hydrogen peroxide catalyzed by phosphotungstic heteropoly acid. Each o

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23

Vesga, Luis C., Thales Kronenberger, Arun Kumar Tonduru, et al. "Tetrahydroquinoline/4,5‐Dihydroisoxazole Molecular Hybrids as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)." ChemMedChem 16, no. 17 (2021): 2686–94. http://dx.doi.org/10.1002/cmdc.202100188.

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24

Mirosław, Barbara, Dmytro Babyuk, Agnieszka Łapczuk-Krygier, Agnieszka Kącka-Zych, Oleg M. Demchuk, and Radomir Jasiński. "Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition." Monatshefte für Chemie - Chemical Monthly 149, no. 10 (2018): 1877–84. http://dx.doi.org/10.1007/s00706-018-2227-6.

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25

B., D. Mistry, R. Desai K., and M. Intwala S. "Synthesis of some biologically active pyrimidine and isoxazole derivatives." Journal of Indian Chemical Society Vol. 91, Dec 2014 (2014): 2263–69. https://doi.org/10.5281/zenodo.5746501.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>E-mail</em> : bhavana_mistry11@yahoo.co.in <em>Manuscript received 04 July 2012, revised 07 July 2014, accepted 10 July 2014</em> 4-(2,5-Dichloro-3-thienyl)-6-substitutedphenylpyrimidine-2(1<em>H</em>)-thione (2a-j), 3-(2,5-dichloro-3-thienyl)-5- substitutedphenyl-4,5-dihydroisoxazole (3a-j) have been synthesized by the reaction of (2<em>E)</em>-1-(2,5-dichloro-3-thienyl)-3- substitutedphenylprop-2-en-1-one (1) with thiourea and hydoxylamine hydrochloride respectively. These compounds have been screened for t

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26

Velikorodov, A. V., E. N. Kutlalieva, N. V. Zolotareva, N. N. Stepkina, and S. B. Nosachev. "Synthesis of Methyl (Hetarylalkyl) N-Allyl-N-phenylcarbamates and Their Transformation into 4,5-Dihydroisoxazole Derivatives." Russian Journal of Organic Chemistry 60, no. 7 (2024): 1186–92. http://dx.doi.org/10.1134/s1070428024070078.

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27

Castelhano, Arlindo L., Roland Billedeau, Diana H. Pliura, Bonnie J. Bonaventura, and Allen Krantz. "Synthesis, chemistry, and absolute configuration of novel transglutaminase inhibitors containing a 3-halo-4,5-dihydroisoxazole." Bioorganic Chemistry 16, no. 3 (1988): 335–40. http://dx.doi.org/10.1016/0045-2068(88)90019-3.

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28

Manikandan, Santhanaraman, Muthian Shanmugasundaram, and Raghavachary Raghunathan. "Synthesis of spiro[3,4-diaryl-4,5-dihydroisoxazole-5,2?-1?,2?,3?,4-tetrahydro-1?-naphthalenone]." Heteroatom Chemistry 12, no. 6 (2001): 463–67. http://dx.doi.org/10.1002/hc.1070.

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29

Pinto, Andrea, Zeina El Ali, Sébastien Moniot, et al. "Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression." ChemistryOpen 7, no. 11 (2018): 858–64. http://dx.doi.org/10.1002/open.201800185.

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30

EICHINGER, K., M. WOKUREK, B. ZAUNER, and M. R. ROSTAMI. "ChemInform Abstract: A Convenient Synthesis of 3- and 3,4-Substituted 4,5-Dihydroisoxazole- 5-acetic Acids." ChemInform 28, no. 42 (2010): no. http://dx.doi.org/10.1002/chin.199742170.

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31

Balsamini, Cesarino, Gilberto Spadoni, Annalida Bedini, Giorgio Tarzia, Maurizio Lanfranchi та Maria Angela Pellinghelli. "4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkylN-(diphenylmethylene)-α,β-dehydroamino acids". Journal of Heterocyclic Chemistry 29, № 6 (1992): 1593–98. http://dx.doi.org/10.1002/jhet.5570290637.

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32

Kara, Yesim S. "Substituent effect study on experimental 13C NMR chemical shifts of (3-(substituted phenyl)-cis-4,5-dihydroisoxazole-4,5-diyl)bis(methylene)diacetate derivatives." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 151 (December 2015): 723–30. http://dx.doi.org/10.1016/j.saa.2015.07.032.

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33

Tavares, Aline, Josene M. Toldo, Guilherme D. Vilela, et al. "Implications of flexible spacer rotational processes on the liquid crystal behavior of 4,5-dihydroisoxazole benzoate dimers." New Journal of Chemistry 40, no. 1 (2016): 393–401. http://dx.doi.org/10.1039/c5nj02199e.

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34

Chernysheva, Natalia B., Anna S. Maksimenko, Fedor A. Andreyanov, et al. "Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules." Tetrahedron 73, no. 48 (2017): 6728–35. http://dx.doi.org/10.1016/j.tet.2017.10.016.

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35

Li, Chaozhong, та Chengye Yuan. "Studies on Organophosphorus Compounds; 70: A Novel Synthesis of Functionalized 4,5-Dihydroisoxazole Derivatives via α-Nitroalkenes". Synthesis 1993, № 05 (1993): 471–72. http://dx.doi.org/10.1055/s-1993-25883.

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36

Sigan, A. L., A. S. Golubev, E. V. Belyaeva, et al. "Synthesis of ethyl 5-aryl-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-carboxylates, exhibiting plant growth-regulating properties." Russian Chemical Bulletin 68, no. 1 (2019): 99–103. http://dx.doi.org/10.1007/s11172-019-2422-6.

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37

Kaur, Manvinder, Mohamad Yusuf, Dharambeer Singh Malhi, and Harvinder Singh Sohal. "Bis-dihydroisoxazolines: Synthesis, Structural Elucidation, Antimicrobial Evaluation, and DNA Photocleavage Assay." Current Organic Synthesis 17, no. 8 (2020): 671–78. http://dx.doi.org/10.2174/1570179417666200713181959.

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Aim and Objective: Isoxazole is an active core found in many drugs. The aim of this work was to synthesize bis-isoxazoline compounds and to analyze the effect of linker chain length on biological activities. Material and Methods: A simple, convenient, and efficient method for the conversion of bischalcones to new bis(4,5-dihydroisoxazole) derivatives was developed by using hydroxylamine hydrochloride under basic medium. Synthesized moieties were also evaluated for their antimicrobial potencies and DNA photocleavage assay. Results and Discussion: The synthesized compounds were more active than

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38

KARA, Yeşim Saniye, Aslı EŞME, and Seda SAGDİNC. "TDOS/PDOS/OPDOS, reduced density gradient (RDG) and molecular docking studies of [3-(3-bromophenyl)-cis-4,5-dihydroisoxazole-4,5-diyl]bis(methylene) diacetate." Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24, no. 1 (2022): 100–110. http://dx.doi.org/10.25092/baunfbed.870307.

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39

Mohsen, G. L., A. M. abdula, A. M. Jassim, W. F. Rodhan, and N. B. Ayrim. "New 3,5-disubstituted-4,5-dihydroisoxazole derivatives: Synthesis, antimicrobial, antioxidant and docking study against glucosamine-6-phosphate synthase." Journal of Physics: Conference Series 1853, no. 1 (2021): 012042. http://dx.doi.org/10.1088/1742-6596/1853/1/012042.

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40

Martins, Marcos A. P., Daniel J. Emmerich, Adilson P. Sinhorin, et al. "Regiospecific synthesis of 1-(5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazole-3-methylene)-5-phenyl-1H-1,2,3-triazoles." Arkivoc 2008, no. 9 (2009): 140–48. http://dx.doi.org/10.3998/ark.5550190.0009.913.

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41

Subbiah Pandi, A., S. Banumathi, D. Velmurugan, S. Shanmuga Sundara Raj, Hoong-Kun Fun, and S. Manikandan. "3-(p-Chlorophenyl)-4-phenyl-4,5-dihydroisoxazole-5-spiro-2′-1′,2′,3′,4′-tetrahydronaphthalen-1′-one." Acta Crystallographica Section C Crystal Structure Communications 57, no. 7 (2001): 819–20. http://dx.doi.org/10.1107/s0108270101003997.

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42

Marotta, Emanuela, Laure Marie Micheloni, Noemi Scardovi, and Paolo Righi. "One-Pot Direct Conversion of 2,3-Epoxy Alcohols into Enantiomerically Pure 4-Hydroxy-4,5-dihydroisoxazole 2-Oxides." Organic Letters 3, no. 5 (2001): 727–29. http://dx.doi.org/10.1021/ol0070379.

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43

Mincheva, Zoia, Martine Courtois, Joël Crèche, Marc Rideau, and Marie-Claude Viaud-Massuard. "One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells." Bioorganic & Medicinal Chemistry 12, no. 1 (2004): 191–97. http://dx.doi.org/10.1016/j.bmc.2003.10.008.

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44

Fedyk, Andrii V., and Bohdan A. Chalyk. "Synthesis of functionalized 4,5-dihydroisoxazoles decorated with the dimethylphosphinoyl group." Journal of Organic and Pharmaceutical Chemistry 21, no. 2 (2023): 41–52. http://dx.doi.org/10.24959/ophcj.23.283988.

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Aim. To synthesize a hybrid molecular platform incorporating dimethylphosphinoyl and 4,5-dihydroisoxazole moieties suitable for the creation of focused combinatorial libraries of compounds.Results and discussion. The base-promoted interaction of halogenoxides with dimethyl(vinyl)phosphine oxide under mild conditions allowed us to obtain 11 isoxazoline–dimethylphosphine oxide hybrids in moderate yields. The reaction was found to be regio- though non-stereoselective. Furoxans were identified as possible side products of the reaction.Experimental part. The one-pot interaction with dimethyl(vinyl)

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45

Eşme, A., S. G. Sagdinc, and Y. S. Kara. "EXPERIMENTAL AND THEORETICAL STUDY OF THE SUBSTITUENT TYPE AND POSITION EFFECTS ON 3-(SUBSTITUTED PHENYL)-CIS-(4,5-DIHYDROISOXAZOLE- 4,5-DIYL)BIS(METHYLENE)DIACETATE DERIVATIVES." Journal of Structural Chemistry 62, no. 6 (2021): 865–75. http://dx.doi.org/10.1134/s0022476621060068.

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46

BALSAMINI, C., G. SPADONI, A. BEDINI, G. TARZIA, M. LANFRANCHI та M. A. PELLINGHELLI. "ChemInform Abstract: 4,5-Dihydroisoxazole and 4,5-Dihydro-1,2,4-oxadiazole Derivatives from Cycloaddition Reactions of Nitrile Oxides to Alkyl N-( Diphenylmethylene)-α,β-dehydroamino Acids." ChemInform 24, № 18 (2010): no. http://dx.doi.org/10.1002/chin.199318076.

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Zadrozna*, I., J. Kurkowska, and I. Makuch. "Enzymatic and Microbial Method of Preparation of Optically Active (±) 3-Methyl-4-phenyl-4,5-dihydroisoxazole-4-carboxylic Acid." Synthetic Communications 27, no. 23 (1997): 4181–91. http://dx.doi.org/10.1080/00397919708005466.

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Vicentino, Amanda Roberta Revoredo, Vitor Coutinho Carneiro, Anderson de Mendonça Amarante, Claudia Farias Benjamim, Alcino Palermo de Aguiar, and Marcelo Rosado Fantappié. "Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a Novel Anti-Inflammatory Drug Candidate." PLoS ONE 7, no. 6 (2012): e39104. http://dx.doi.org/10.1371/journal.pone.0039104.

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Righi, Paolo, Noemi Scardovi, Emanuela Marotta, Peter ten Holte, and Binne Zwanenburg. "Solution- and Solid-Phase Synthesis of 4-Hydroxy-4,5-dihydroisoxazole Derivatives from Enantiomerically PureN-Tosyl-2,3-aziridine Alcohols." Organic Letters 4, no. 4 (2002): 497–500. http://dx.doi.org/10.1021/ol0170152.

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Kotian, Sumana Y., Narayana U. Kudva N, K. Byrappa, and K. M. Lokanatha Rai. "Synthesis of New Series of 4,5-Dihydroisoxazole-5-carbonitrile Derivatives for the Study of their Liquid Crystalline Properties." Materials Today: Proceedings 3, no. 10 (2016): 4082–87. http://dx.doi.org/10.1016/j.matpr.2016.11.077.

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