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Journal articles on the topic '-(4'-Aminophenyl)-6-methyl benzothiazole'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Chandni, Jain, Gopal Ram, Panwar Lalita, and Nagar Meena. "Phosphorylation and thiophosphorylation of 2-(4'-aminophenyl)-6-methyl benzothiazole and their biological activities." Journal of Indian Chemical Society 93, June 2016 (2016): 571–75. https://doi.org/10.5281/zenodo.5638395.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : nagar_meena@yahoo.com <em>Manuscript received online 15 December 2015, accepted 30 January 2016</em> Some novel organophosphorus compounds of the type [(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(O)Cl<sub>3-n</sub>]/[(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(S)Cl<sub>3-n</sub>] {where n=1–3} have been easily synthesized by the reaction of 2-(4'-aminophenyl)-6-methyl benzothiazole (C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S) with phosphorus oxychloride

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2

Gineinah, Magdy. "6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS." Scientia Pharmaceutica 69, no. 1 (2001): 53–61. http://dx.doi.org/10.3797/scipharm.aut-01-06.

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Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazoline were prepared by cyclization with phenylhydrazine of the appropriate 1,3-diphenyl-2-propen-1-one derivatives obtained from arninoacetophenone and differently substituted aldehydes. However, the newly synthesized 2-aminobenzothiazole derivatives of pyrazoline were subjected to cyclization with ethyl brornopyruvate to afford the formation of 6-

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3

Phillips, Lawrence R., Chris Bramhall, John Buckley, Tracy W. Daw, and Sherman F. Stinson. "Analysis of 2-(3-methyl-4-aminophenyl)-benzothiazole (NSC 674495) in plasma by gas chromatography with mass-selective detection." Journal of Chromatography B: Biomedical Sciences and Applications 732, no. 2 (1999): 315–21. http://dx.doi.org/10.1016/s0378-4347(99)00295-9.

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4

Al-Amiery, A. A., A. A. Al-Temimi, A. A. H. Kadhum, et al. "Co-crystal structure of mixed molecules of methyl 2-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yloxy)acetate and 2-(2-aminophenyl)benzothiazole." Journal of Structural Chemistry 54, no. 3 (2013): 648–49. http://dx.doi.org/10.1134/s002247661303030x.

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5

Meng, Hangyu, Hongxia Li, Wei Xu, Sujin Zhang, and Siyuan Wu. "Synthesis and Application of Novel Benzothiazole Fluorescent Probes." Journal of Life Sciences and Agriculture 1, no. 3 (2024): 74–78. https://doi.org/10.62517/jlsa.202407311.

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As a new detection method, fluorescent probe plays a very important role in many fields. The variety of probe is more and more, the specificity of detection is more and more strong, the range is more and more wide, the detection sensitivity is more and more good. Compared with the traditional detection method, the fluorescence probe has higher selectivity and no obvious toxic and negative effect, and has good sensitivity and simple and convenient operation, can be very good for living cells or living animals, plants and other advantages of tracking imaging, Therefore, the development of new fl

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6

Hong, Yan-Ping, Bao-An Song, and Xin-Chen Shangguan. "Dimethyl [(4-fluorophenyl)(6-methoxybenzothiazol-2-ylamino)methyl]phosphonate." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1199—o1200. http://dx.doi.org/10.1107/s1600536809015384.

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In the molecule of title compound, C17H18FN2O4PS, both the benzene ring with its conjunction C atom and the benzothiazole ring with its conjunction N atom are close to planar (the maximum deviations are 0.0267 and 0.0427 Å for the benzene and benzothiazole rings, respectively), the dihedral angle between the planes of the benzothiazole and benzene rings is 119.05 (3)°. The molecular packing is stabilized by intermolecular N—H...O, C—H...N and C—H...F hydrogen bonding, and by C—H...π and π–π stacking interactions [centroid–centroid distances = 2.99 (2), 2.96 (3), 2.88 (2) and 3.773 (4) Å].

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7

Carmona-Negrón, José A., Mayra E. Cádiz, Curtis E. Moore, Arnold L. Rheingold, and Enrique Meléndez. "New platinum(II) complexes with benzothiazole ligands." Acta Crystallographica Section E Crystallographic Communications 72, no. 3 (2016): 412–16. http://dx.doi.org/10.1107/s2056989016002826.

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Four new platinum(II) complexes, namely tetraethylammonium tribromido(2-methyl-1,3-benzothiazole-κN)platinate(II), [NEt4][PtBr3(C8H7NS)] (1), tetraethylammonium tribromido(6-methoxy-2-methyl-1,3-benzothiazole-κN)platinate(II), [NEt4][PtBr3(C9H9NOS)] (2), tetraethylammonium tribromido(2,5,6-trimethyl-1,3-benzothiazole-κN)platinate(II), [NEt4][PtBr3(C10H11NS)] (3), and tetraethylammonium tribromido(2-methyl-5-nitro-1,3-benzothiazole-κN)platinate(II), [NEt4][PtBr3(C8H6N2O2S)] (4), have been synthesized and structurally characterized by single-crystal X-ray diffraction techniques. These species ar

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8

Srivastav, Manish, MD Salahuddin, and S. M. Shantakumar. "Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4 (3H)-ones." E-Journal of Chemistry 6, no. 4 (2009): 1055–62. http://dx.doi.org/10.1155/2009/507052.

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A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4(3H)-ones were synthesized by treating 2-(chloromethyl)-3-(6-substituted-1, 3-benzothiazole-2-yl) quinazoline-4-(3H)-one (IIa-d) with various substituted amine. The compounds (IIa-d) prepared by treating 2-[(chloroacetyl) amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inf

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9

Patel, Sachin V., Manish Patel, and Rangan Patel. "Synthesis and characterization of novel substituted spiro[isobenzofuran-1(3H), 9’-xanthene]-3-ones." Journal of the Serbian Chemical Society 70, no. 7 (2005): 931–36. http://dx.doi.org/10.2298/jsc0507931p.

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The ketoacid, 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid, prepared from N,N-diethyl-m-aminophenol and phthalic anhydride, was reacted with various substituted 3-[6-methoxybenzothiazol-2-yl]-4(3H)-quinazolinones in the presence of a dehydration condensing agent to afford novel spiro[isobenzofuran-1(3H),9?-xanthene]-3-ones. The benzothiazolyl quinazolinones were synthesized by reacting 2-amino-6-methoxybenzothiazole with various substituted benzoxazinones. All compounds were characterized by melting point determination, elemental analysis, infra- red spectroscopy NMR-spectroscopy and UV-vis

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10

Zhang, Chun-Tao, Jie-Hua Wu, Li-Na Zhou, Yong-Li Wang, and Jing-Kang Wang. "(R)-(–)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one." Acta Crystallographica Section E Structure Reports Online 62, no. 7 (2006): o2999—o3000. http://dx.doi.org/10.1107/s1600536806022409.

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The title compound, C11H13N3O, is a key intermediate in the synthesis of cardiotonic agents. The asymmetric unit consists of two molecules of the same enantiomer and the crystal packing is stabilized by intermolecular N—H...O hydrogen bonds.

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11

Rajeev, Jain, Shrivastava Sadhana, and Bhadauria Akhilesh. "Synthesis of some pyrazole and pyrimidine derivatives of sulfonamides." Journal of India Chemical Society Vol 81, Aug 2004 (2004): 692–93. https://doi.org/10.5281/zenodo.5830189.

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School of Studies in Chemistry, Jiwaji University. Gwalior-474 011, India <em>E-mail</em>: gwlsosmica@sancharnet.in<em>       Fax </em>: 91-751-2346209 <em>Manuscript received 9 January' 2003, revised 12 January 2004 accepted 6 April 2004</em> 1- Carboxymethylpyridinium-3-aminophenyl-5-methyl-4-(4'-sustituted)sulfonamoy lazopyrazoles (2a-f) and 2-amino-4-methyl- 6-(4' -aminotoIudyl)-5-( 4'-sulfonamoyl)azopyrimidines (3a- f) were synthesized by condensation of 1-aminophenlyl-2-( 4'substituted) sulfonamoylhydrazonohutane-1 ,3-dione

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12

Abdel-Azzem, M., S. H. El-Hamouly, and A. A. Hathoot. "Electrochemical copolymerization of 2-(4-amino phenyl)-6-methyl benzothiazole and aniline." European Polymer Journal 31, no. 12 (1995): 1207–13. http://dx.doi.org/10.1016/0014-3057(95)00073-9.

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13

Toiserkani, Hojjat. "Synthesis and evaluation of properties of novel aromatic poly(ether-imide) with benzazole pendent groups and flexible ether linkages." High Performance Polymers 23, no. 7 (2011): 542–54. http://dx.doi.org/10.1177/0954008311421988.

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Three types of new bis(ether-amine) monomers such as 5-(2-benzimidazole)-1,3-bis(4-aminophenoxy)benzene (3), 5-(2-benzoxazole)-1,3-bis(4-aminophenoxy)benzene (4), and 5-(2-benzothiazole)-1,3-bis(4-aminophenoxy)benzene (5) were prepared in three steps, starting from the reaction of 3,5-dihydroxybenzioc acid with 4-fluronitrobenzene in N, N-dimethylformamide (DMF) solution in the presence of potassium carbonate, followed by catalytic reduction of the intermediate dinitro-carboxylic acids, and subsequent condensation of the resulting diamino-carboxylic acids and 1,2-phenylenediamine, 2-aminopheno

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14

Zeng, Qing, Demin Ren, Xingliang Fu, and Xiaofang Li. "Synthesis of Spiro[Pyrrolo[2,1-b][1,3]Benzothiazole-3,2′-[1,3]Thiazolo[3,2-a] Pyrimidine] via Cycloaddition Reactions." Journal of Chemical Research 42, no. 5 (2018): 260–63. http://dx.doi.org/10.3184/174751918x15260567362969.

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The 1,3-dipolar cycloaddition reaction of ethyl-5-aryl-2-[( Z)-2-methoxy-2-oxoethylidene]-7-methyl-3-oxo-3,5-dihydro-2 H-thiazolo[3,2- a] pyrimidine-6-carboxylates and azomethine ylide, which was generated in situ by the reaction of N-4-methoxyphenacylbenzothiazolium bromides and triethylamine, yielded novel 6′-ethyl-2-methyl-5′-aryl-1-(4-methoxybenzoyl)-7-methyl-3′-oxo-1,2-dihydro-5 H-spiro[pyrrolo[2,1- b][1,3]benzothiazole-3,2′-[1,3]thiazolo[3,2- a]pyrimidine]-2,6′-dicarboxylates in moderate yields. The structures of all of the products were characterised by NMR, IR, HRMS spectrometry, toget

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15

Gerelt-Od, Ya, A. Solongo, S. Javzan, S. Philipov, and D. Selenge. "Alkaloids from Sedum telephium L." Mongolian Journal of Chemistry 16 (March 22, 2016): 44–47. http://dx.doi.org/10.5564/mjc.v16i0.670.

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The crude alkaloid mixtures from the aerial parts S.telephium was analyzed by GC-MS method. As a result 14 compounds, including 6 alkaloids were characterized. 3-methyl-2-carbethoxyindole (4.730%), 2-(2-hydroxyphenyl) benzothiazole (1.576%) and N,4, 5-trimethyl phenyl-1,2-diamine, (1.217%) were in higher contents. One sulfur-containing alkaloid 2-(2-hydroxyphenyl) benzothiazole has been identified. These six alkaloids are described for the first time from this plant.Mongolian Journal of Chemistry 16 (42), 2015, 44-47

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16

Hafez, Hend N., and Abdel-Rhman B. A. El-Gazzar. "Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives." Acta Pharmaceutica 67, no. 4 (2017): 527–42. http://dx.doi.org/10.1515/acph-2017-0039.

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Abstract 3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3

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17

Rajeev, Jain, and Shrivastava Sadhana. "Electrochemical investigations on some 1-carboxymethylpyridinium-3-aminophenyl-5-methyl-4-[ 4' -sulfonamoyl]azopyrazoles." Journal of Indian Chemical Society Vol. 80, Jan 2003 (2003): 30–32. https://doi.org/10.5281/zenodo.5835516.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 Oil, India <em>E-mail :</em> gwlsosmica@sancharnet.in         Fax : 91-0751-2346209 <em>Manuscript received 31 March 2000, revised 26 April 2002, accepted 6 September 2002</em> The electrochemical behavior of 1-carboxymethylpyridinium-3-aminophenyl-5-methyl-4-[ 4' -sulfonamoyl]azopyrazoles has been studied on the basis of d.c. polarography, cyclic voltammetry and coulometry in Britton-Robinson buffers in the pH range 2.5-12.0. The electroreduction occurs in a single, well defined, 2<em>e</em> step at dr

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18

Shetty, Chaithra R., Ishwar K. Bhat, Abhishek Kumar, Vijay Kumar Merugumolu, Revanasidappa BC, and Banylla Felicity Dkhar Gatphoh. "CONVENTIONAL AND MICROWAVE SYNTHESIS AND ANTIOXIDANT EVALUATION OF BENZOTHIAZOLE SUBSTITUTED 4-THIAZOLIDINONES." INDIAN DRUGS 57, no. 10 (2021): 17–22. http://dx.doi.org/10.53879/id.57.10.12175.

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Antioxidants exert their action chiefly in controlling and preventing the free-radicals and their reactions and thus it has a vital role as health protecting factor. There are many scientific data proposing that antioxidants lower the threats of some chronic diseases including cancer and heart disease. In the present work, the hybrid molecule i.e benzothiazole substituted 4-thiazolidinone, has been taken for the study and different novel benzothiazole substituted 4-thiazolidinone derivatives were synthesized by reacting 2-amino-6-methyl benzothiazole with aromatic aldehydes in alcohol media. T

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19

Sun, Xue-Tong, Xiu-Guang Wang та Xiao-Jun Zhao. "Bis(2-amino-6-methyl-1,3-benzothiazole-κN3)bis(4-nitrobenzoato-κO1)zinc". Acta Crystallographica Section E Structure Reports Online 67, № 7 (2011): m933. http://dx.doi.org/10.1107/s1600536811022331.

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20

Haroun, Michelyne. "In Silico Design, Synthesis and Evaluation of Novel Series of Benzothiazole- Based Pyrazolidinediones as Potent Hypoglycemic Agents." Medicinal Chemistry 16, no. 6 (2020): 812–25. http://dx.doi.org/10.2174/1573406416666191227113716.

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Background: The discovery of novel ligand binding domain (LBD) of peroxisome proliferator- activated receptor γ (PPARγ) has recently attracted attention to few research groups in order to develop more potent and safer antidiabetic agents. Objective: This study is focused on docking-based design and synthesis of novel compounds combining benzothiazole and pyrazolidinedione scaffold as potential antidiabetic agents. Methods: Several benzothiazole-pyrazolidinedione hybrids were synthesized and tested for their in vivo anti-hyperglycemic activity. Interactions profile of title compounds against PP

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21

Siluvairaj, Richard Rajkumar, Vallal Perumal Govindasamy, Rajarajan Govindasamy, Periyanayagasamy Vanathu Chinnappan, and Thanikachalam Venugopal. "Comparative study of 4-((4-aminophenyl)diazenyl)-2-((2-phenylhydrazono)methyl)phenol and N-(4-((4-hydroxy-3-((2-phenylhydrazono)methyl)phenyl)diazenyl)phenyl)acetamide - DFT method." European Journal of Chemistry 15, no. 1 (2024): 50–70. http://dx.doi.org/10.5155/eurjchem.15.1.50-70.2498.

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Theoretical calculation of 4-((4-aminophenyl)diazenyl)-2-((2-phenylhydrazono)methyl) phenol (1) and N-(4-((4-hydroxy-3-((2-phenylhydrazono)methyl)phenyl)diazenyl)phenyl) acetamide (2) was studied by DFT/B3LYP/6-311+G(d,p) basis set. The calculated values of geometric structural parameters, Fourier transform infrared spectral data, highest occupied molecular orbital and lowest unoccupied molecular orbital, natural bond orbital, nucleus-independent chemical shifts, Fukui function, polarizability, hyperpolarizability, and UV data of compounds 1 and 2 clearly indicate that substitution of the amin

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22

M. Patel, Sejalkumari, Paresh S. Patel, and Keshav C. Patel. "SYNTHESIS AND APPLICATIONS OF SOME REACTIVE DYES HAVING QUINAZOLIN-4(3H)-ONE MOIETY." International Journal of Advanced Research 10, no. 03 (2022): 506–19. http://dx.doi.org/10.21474/ijar01/14412.

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Some reactive dyes (6a-6l) having Quinazolin-4(3H)-one reactive system have been synthesized by coupling of diazotized 3-(4-(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl) phenyl)-4-oxo-2-phenyl-3,4-dihydroquinazoline-6-sulphonic acid with cyanurated coupling components such as H-acid, J-acid, N-methyl J-acid, Gamma acid, Peri acid, Sulpho Tobias acid, Koch acid, Bronners acid, Chicago acid, K-acid, N-Phenyl J-acid and M-acid. The synthesized dyes were characterized by nitrogen elemental analysis, IR, and 1H-NMR spectra. They were applied on wool, silk, and cotton fibres. Their dyeing properties, fas

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23

Lungu, Lidia, Caleria Cucicova, Svetlana Blaja, et al. "Synthesis of Homodrimane Sesquiterpenoids Bearing 1,3-Benzothiazole Unit and Their Antimicrobial Activity Evaluation." Molecules 27, no. 16 (2022): 5082. http://dx.doi.org/10.3390/molecules27165082.

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Based on some homodrimane carboxylic acids and their acyl chlorides, a series of fourteen 2-homodrimenyl-1,3-benzothiazoles, N-homodrimenoyl-2-amino-1,3-benzothiazoles, 4′-methyl-homodrimenoyl anilides and 4′-methyl-homodrimenthioyl anilides were synthesized and their biological activities were evaluated on five species of fungi (Aspergillus niger, Fusarium solani, Penicillium chrysogenum, P. frequentans, and Alternaria alternata) and two strains of bacteria (Bacillus sp. and Pseudomonas aeruginosa). The synthesis involved the decarboxylative cyclization, condensation and thionation of the sai

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24

Fun, Hoong-Kun, Suhana Arshad, M. Himaja, D. Munirajasekhar, and B. K. Sarojini. "2-[5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-6-methyl-1,3-benzothiazole." Acta Crystallographica Section E Structure Reports Online 67, no. 9 (2011): o2412. http://dx.doi.org/10.1107/s1600536811033666.

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Alhuwaymil, Zamzam, Zuhair M. Mohammedsaleh, Mamdoh S. Moawadh, et al. "Empirical and molecular docking-based screening of heterocyclic compounds to identify potential acetylcholinesterase inhibitors to treat Alzheimer’s disease and its histology." Egyptian Pharmaceutical Journal 22, no. 4 (2023): 659–75. http://dx.doi.org/10.4103/epj.epj_155_23.

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Background Alzheimer’s disease (AD) is characterized by neuropathological symptoms, there has been no proper cure in recent era. It was linked to a deficiency in the brain neurotransmitter acetylcholine. Acetylcholinesterase is an enzyme that breaks down acetylcholine to an inactive form and the death of cholinergic neurons. Objective Therefore, there is a crucial need to identify alternative compounds with potential anti-cholinesterase agents and minimal undesirable effects. Fluoroquinolones and benzimidazole-benzothiazole derivatives offer antimicrobial, anti-inflammatory, anti-oxidant, anti

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Nguyen, Thi Thu Huong, Jiří Urban, Eva Klinotová, et al. "Synthesis of Several Hydroxylated 23-(Benzimidazol-2-yl-, Benzoxazol-2-yl and Benzothiazol-2-yl)norcholanes and Some Related Compounds." Collection of Czechoslovak Chemical Communications 60, no. 2 (1995): 257–75. http://dx.doi.org/10.1135/cccc19950257.

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The bile acids Ia - Id (lithocholic, chenodeoxycholic, deoxycholic, cholic) and their derivatives (O-acetylated acids and O-acetylated acid chlorides) reacted under various conditions with 1,2-diaminobenzene, 2-aminophenol and 2-aminothiophenol and afforded the title benzimidazoles II and VII, benzoxazoles V and benzothiazoles VI. Alkylation of the benzimidazole derivative IIa with 2-dimethylaminoethyl chloride resulted in 3α-hydroxy-23-[1-(2-dimethylaminoethyl)ben zimidazol-2-yl]- norcholane (IVa). The use of 1,2-diamino-4-methylbenzene enabled the preparation of 3α-acetoxy-23-[5(6)-methylben

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Rodríguez, Diego, Sergio Andrés Guerrero, Alirio Palma, Justo Cobo, and Christopher Glidewell. "4-Styrylquinolines from cyclocondensation reactions between (2-aminophenyl)chalcones and 1,3-diketones: crystal structures and regiochemistry." Acta Crystallographica Section C Structural Chemistry 76, no. 9 (2020): 883–90. http://dx.doi.org/10.1107/s2053229620010803.

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Structures are reported for two matched sets of substituted 4-styrylquinolines which were prepared by the formation of the heterocyclic ring in cyclocondensation reactions between 1-(2-aminophenyl)-3-arylprop-2-en-1-ones with 1,3-dicarbonyl compounds. (E)-3-Acetyl-4-[2-(4-methoxyphenyl)ethenyl]-2-methylquinoline, C21H19NO2, (I), (E)-3-acetyl-4-[2-(4-bromophenyl)ethenyl]-2-methylquinoline, C20H16BrNO, (II), and (E)-3-acetyl-2-methyl-4-{2-[4-(trifluoromethyl)phenyl]ethenyl}quinoline, C21H16F3NO, (III), are isomorphous and in each structure the molecules are linked by a single C—H...O hydrogen bo

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28

Araki, Tsutomu, Yasuko Muramatsu, Katsuyuki Tanaka, Mitsunobu Matsubara, and Yutaka Imai. "Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice." Neuroscience Letters 312, no. 1 (2001): 50–54. http://dx.doi.org/10.1016/s0304-3940(01)02176-0.

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Helilusiatiningsih, Nunuk. "IDENTIFIKASI SENYAWA KIMIA PADA BUAH SEGAR TERUNG POKAK (Solanum torvum) DENGAN METODE LCMS." Journal of Food Technology and Agroindustry 3, no. 1 (2021): 1–12. http://dx.doi.org/10.24929/jfta.v3i1.1179.

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The content of antioxidant compounds in pokak eggplant (Solanum torvum) had the potential as an herbal medicine and was consumed by the world population. The research objective was to study the chemical compound content of the LCMS method. Experimental design with fresh fruit extraction of pokak eggplant using 95% ethanol solvent. The parameters measured were the chemical components found in fresh fruit. The results of analysis of chemical compounds include Choline, Proline, Bis (2-ethylhexyl) phthalate, BMK ethyl glycidate, 4- Methoxycinnamic acid, chlorogenic acid, 7- Hydroxycoumarine, Trigo

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Rodríguez, Ricaurte, Manuel Nogueras, Justo Cobo, and Christopher Glidewell. "Different hydrogen-bonded structures in the isomeric solvates 2-amino-6-anilino-4-methoxy-5-[(E)-4-nitrobenzylideneamino]pyrimidine dimethyl sulfoxide solvate and 2-amino-6-[methyl(phenyl)amino]-5-[(E)-4-nitrobenzylideneamino]pyrimidin-4(3H)-one dimethyl sulfoxide solvate." Acta Crystallographica Section C Crystal Structure Communications 65, no. 3 (2009): o111—o114. http://dx.doi.org/10.1107/s0108270109004181.

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The title solvates, (I) and (II), both C18H16N6O3·C2H6OS, are isomeric. The conformations adopted by the 6-substituent are significantly different, with the 6-aminophenyl unit remote from the nitrophenyl ring in methoxypyrimidine (I) but adjacent to it in pyrimidinone (II). Pairs of pyrimidine molecules in (I) are linked by N—H...N hydrogen bonds to form cyclic centrosymmetric dimers from which the dimethyl sulfoxide molecules are pendent, while in (II) a combination of three independent N—H...O hydrogen bonds links the components into a chain containing bothR22(8) andR42(8) rings, in which th

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Kaya, Betül, Weiam Hussin, Leyla Yurttaş, et al. "Design and Synthesis of New 1,3,4-Oxadiazole – Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents." Drug Research 67, no. 05 (2017): 275–82. http://dx.doi.org/10.1055/s-0042-119070.

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AbstractLooking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel N’-(arylidene)-2-(3-methoxyphenoxy)acetohydrazide derivatives (4a–f)/1-(4-substitutedphenyl)-2-[(5-[(3-methoxyphenoxy)methyl]-1,3,4-oxadiazol-2-yl)thio]ethan-1-one derivatives (6a–f)/N-(6-substitutedbenzothiazol-2-yl)-2-[(5-[(3-methoxyphenoxy)methyl]-1,3,4-oxadiazol-2-yl)thio]acetamide derivatives (7a–e) were obtained and evaluated for their in vitro antimicrobial activity a

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Sumrra, Sajjad Hussain, Wardha Zafar, Sabaahatul Ain Malik, Khalid Mahmood, Syed Salman Shafqat, and Saira Arif. "Metal Based Bioactive Nitrogen and Oxygen Donor Mono and Bis Schiff Bases: Design, Synthesis, Spectral Characterization, Computational Analysis and Antibacterial Screening." Acta Chimica Slovenica 69, no. 1 (2022): 200–216. https://doi.org/10.17344/acsi.2021.7182.

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The scientific interest in developing the advanced metal based compounds to inhibit and control bacterial infections is continuously rising. Keeping in view their pharmacological significance, two new bioactive symmetrical phenylenediamine mono- and bis-Schiff bases, 2-{[(4-aminophenyl)imino]methyl}-6-methoxyphenol (L1) and 2,2’-{benzene-1,2-diylbis[nitrilomethylylidene]}bis(6-methoxyphenol) (L2) have been synthesized and characterized by using physical techniques, spectral methods, elemental and DFT based computational analysis with B3LYP/6-311++G(d, p) basis set. Furthermore, the synthesized

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Sharma, Diksha, Archana Sharma, Rakesh Pahwa, Avtar Chand Rana, and Prabodh Chander Sharma. "Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4622–28. http://dx.doi.org/10.55522/jmpas.v11i2.2470.

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A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL

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El-Shamy, I. E., E. Hleli, M. A. El-Hashash, I. Kelnar, and A. M. Abdel-Mohsen. "2-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone Synthon for Some New Annelated 1,2,3-Selena/Thiadiazoles and 2H-Diazaphospholes with Anticipated Biological Activity and Quantum Chemical Calculations." Molecules 28, no. 3 (2023): 1280. http://dx.doi.org/10.3390/molecules28031280.

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A convenient and efficient synthetic protocol for the new selenadiazole. Thiadiazole and diazaphosphole derivatives incorporating a pyridazine moiety originating from 4-(4-aminophenyl)-4-oxobutanoic acid (1) were described. All newly synthesized compounds were evaluated for their antimicrobial activity using the disk diffusion method, and their cytotoxicity was evaluated against brine shrimp lethality bioassay. Using density functional theory (DFT), the frontier molecular orbital (FMO) and molecular electrostatic potential (MEPS) were studied to estimate the chemical reactivity and kinetic sta

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Mehmet, Ferdi Fellah, Gulhan Bakirdere Emine, Canpolat Erdal, and Kaya Mehmet. "A density functional theory study of [(4-aminophenyl)imino]methyl-6-methoxy4-nitrophenol complexes with Co, Ni, Cu and Zn metals." Journal of Indian Chemical Society Vol. 91, Jul 2014 (2014): 1321–26. https://doi.org/10.5281/zenodo.5726323.

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Chemical Engineering Department, Bursa Technical University, 16190, Bursa, Turkey <em>E-mail</em> : mffellah@gmail.com, mferdi.fellah@btu.edu.tr<em> Fax</em> : 90-224-3141650 Department of Science Education, Ylldlz Technical University, 34220, Istanbul, Turkey <em>E-mail</em> : bgulhan@yildiz.edu.tr <em>Fax</em> : 90-212-3834808 Department of Elementary Science Education, Flrat University, 23119, Elazlg, Turkey Department of Chemistry, Flrat University, 23119, Elazlg, Turkey <em>Manuscript received online 10 September 2013, revised 05 February 2014, accepted 06 February 2014</em> The optimizat

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Ajmal, M., A. S. Mideen, and M. A. Quraishi. "2-hydrazino-6-methyl-benzothiazole as an effective inhibitor for the corrosion of mild steel in acidic solutions." Corrosion Science 36, no. 1 (1994): 79–84. http://dx.doi.org/10.1016/0010-938x(94)90110-4.

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Millhollon, Rex W., and Hideo Koike. "Combined Effect of Disease and Herbicide Treatment on Yield of Sugarcane (Saccharum officinarum)." Weed Science 34, no. 1 (1986): 137–42. http://dx.doi.org/10.1017/s0043174500026606.

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Sugarcane (Saccharum officinarumL.) was planted in the fall; the seed cane was healthy or infected either with sugarcane mosaic virus (strain H) or with ratoon stunting disease (RSD) (Clavibacter xyli). Herbicide treatments were applied the following spring and each subsequent spring during the 3-yr crop cycle. Hexazinone [3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione] at 1.1 kg ai/ha was applied as a soil foliage treatment when sugarcane was about 30 cm tall. The methyl ester of diclofop {(±)-2-[4-(2,4-dichlorophenoxy)phenoxy] propanoic acid} at 1.1 kg ai/ha and the

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38

Ajay, M. Chaturvedi &. Vikas Vijayvargiya. "SYNTHESIZED AND GEOMETRY OPTIMIZATION OF DIFFERENT SUBSTITUTED NITROGEN AND SULPHUR CONTAINING HETEROCYCLES." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES [FRTSSDS- June 2018] (June 22, 2018): 330–35. https://doi.org/10.5281/zenodo.1296246.

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A series of some novel 2-(5-methyl-1, 3, 4-thiadiazole-2-yl)-1H-Benzimidazole and 2-(1H-benzimidazol-2-yl)-1,3-benzothiazole derivatives were designed and synthesized under microwave irradiation via multistep reaction. The structures of substituted nitrogen and suphur containing heterocycles were confirmed by 1H NMR, MS, IR. The antibacterial activities of substituted nitrogen and suphur containing heterocycles were determined. The antibacterial activity results indicated that the compounds Ib, Ie, and Jd exhibited good activity against Staphylococcus aureus, and the compounds Ic and If displa

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Thees, S., B. Neumaier, S. Deisenhofer, et al. "Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans." Nuklearmedizin 46, no. 05 (2007): 175–80. http://dx.doi.org/10.1160/nukmed-0077.

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SummaryAim: [N-methyl-11C]2-(4'-(methylaminophenyl)-benzothiazole (11C-BTA-1) is a thioflavin-T derivative that has been one of the promising PET tracers for imaging of amyloid plaque distribution in the Alzheimer patients brain in vivo. The biodistribution and dosimetry of this tracer in humans is presented and compared to the results of a previous dosimetry and biodistribution study of another thioflavin-T derivative [N-methyl-11C]2-hydroxy-(4'-(methylaminophenyl)- benzothiazole (11C-OH-BTA-1) in baboons. Methods: Five subjects underwent 2D dynamic PET imaging. Source organs were segmented u

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Nalewaja, John D., and Zenon Woznica. "Effect of Environment and Adjuvants on Asulam Phytotoxicity." Weed Science 36, no. 3 (1988): 367–72. http://dx.doi.org/10.1017/s0043174500075032.

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Experiments were conducted to determine the influence of various factors on asulam {methyl[(4-aminophenyl)sulfonyl] carbamate} toxicity to flax (Linum usitatissimumL.) and wild oats (Avena fatuaL. # AVEFA). Asulam toxicity to both flax and wild oats generally increased as temperature, humidity, and soil moisture increased after treatment. Octoxynol {α-[p-1,1,3,3-tetramethyl butyl phenyl]-ω-hydroxypoly(oxyethylene)} in the spray solution increased asulam toxicity to both species in all environments. Octoxynol and trimethylenonypolyethoxyethanol (WK) enhanced asulam toxicity more than other adju

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Adinehnia, Morteza, Jeremy R. Eskelsen, K. W. Hipps, and Ursula Mazur. "Mechanical behavior of crystalline ionic porphyrins." Journal of Porphyrins and Phthalocyanines 23, no. 01n02 (2019): 154–65. http://dx.doi.org/10.1142/s1088424619500147.

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Mechanical properties of six different binary ionic porphyrin crystals with variable morphologies were measured and correlated with their structural properties. These solids were formed from stoichiometric combinations of negatively charged tectons, meso-tetra(4-sulfonatophenyl)porphyrin (TSPP), Cu(II) meso-tetra(4-sulfonatophenyl)porphyrin (CuTSPP), Ni(II) meso-tetra (4-sulfonatophenyl)porphyrin (NiTSPP), and four different cationic tectons, namely, meso-tetra (4-pyridyl)porphyrin (TPyP), tetra([Formula: see text]-methyl-4-pyridyl)porphyrin (TMPyP), Cu(II) meso-tetra([Formula: see text]-methy

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42

Pallai, Debraj, Melwin Diego Dsouza, Kalimoddin I. Momin, et al. "Synthesis, Spectroscopic Characterization, and Biological Assessment of Novel Benzothiazole Derivatives Bound to Transition Metal Complexes." Oriental Journal Of Chemistry 40, no. 3 (2024): 806–14. http://dx.doi.org/10.13005/ojc/400324.

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A range of metal complexes derived from the HBTADH ligand (4-{[(6-chloro-1,3-benzothiazol-2-yl)imino]methyl}benzene-1,4-diol) have been synthesized, and their structural characterization has been conducted, yielding compounds of the type [M(BTADH)2]. Electron spin resonance (ESR), electronic absorption, mass, electromagnetic moments, NMR, infrared, and C, H, N, and S analysis spectroscopy were some of the methods used for characterization. A tetrahedral geometry has been projected for the complexes containing Hg(II), Zn(II), and Cd (II), but a high spin octahedral geometry is anticipated for t

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Richard, Edward P. "Influence of Surfactants on the Toxicity of Asulam to Johnsongrass (Sorghum halepense) and Sugarcane (Saccharumsp.)." Weed Science 34, no. 2 (1986): 299–303. http://dx.doi.org/10.1017/s0043174500066856.

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The influence of surfactant type and concentration on the efficacy of asulam {methyl [(4-aminophenyl) sulfonyl] carbamate} for controlling rhizomatous johnsongrass [Sorghum halepense(L.) Pers. # SORHA] was evaluated in field and greenhouse studies. Under field conditions, nonoxynol (9 to 10 POE) [α-lp-nonylphenyl)-w-hydroxypoly (oxyethylene)] applied at concentrations of 6% (v/v) with asulam at 2.8 kg ai/ha reduced rhizomatous johnsongrass biomass by 35%, with no consistently significant difference in asulam's performance between surfactant concentrations of 0 and 3% (v/v) being observed. Asul

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44

Sokolenko, Liubov V., Taras M. Sokolenko, Andrey A. Filatov, Oleksandr D. Shchehlov, Vitalii V. Rudiuk, and Yurii L. Yagupolskii. "Development of a Multistage Technology for the Industrial Synthesis of the Levosimendan API and Enantiomeric Separation of Intermediates." Journal of Organic and Pharmaceutical Chemistry 23, no. 2 (2025): 35–47. https://doi.org/10.24959/ophcj.25.322447.

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A method for obtaining Levosimendan suitable for industrial application has been developed. Two literature routes for the synthesis have been evaluated. It has been found that the use of enantiopure (R)-2-chloropropionyl chloride in the initial step is ineffective due to racemization at the stage of the synthesis based on the malonic ester. Instead, a reported method based on the synthesis of the Levosimendan precursor, 6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (1), from racemic 2-bromopropionyl bromide has been modified to allow for scale-up and adaptation to industrial proces

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Fernández, Héctor, and Marı́a Alicia Zón. "Novel studies on the electrochemical oxidation of 2-[4-(N,N-dimethylamino)phenyl]-6-methyl benzothiazole (DPMB) in acetonitrile at platinum electrodes." Journal of Electroanalytical Chemistry 572, no. 1 (2004): 129–43. http://dx.doi.org/10.1016/j.jelechem.2004.05.028.

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McCarty, Lambert B., and Daniel L. Colvin. "Buffalograss Tolerance to Postemergence Herbicides." HortScience 27, no. 8 (1992): 898–99. http://dx.doi.org/10.21273/hortsci.27.8.898.

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Buffalograss [Buchloe dactyloides (Nutt.) Engelm.] is a turfgrass species traditionally adapted to low-rainfall areas that may incur unacceptable weed encroachment when grown in higher rainfall areas such as Florida. An experiment was performed to evaluate the tolerance of two new buffalograss cultivars, `Oasis' and `Prairie', to postemergence herbicides commonly used for grass, broadleaf, and sedge weed control. Twenty to 40 days were required for each cultivar to recover from treatment with asulam, MSMA, and sethoxydim (2.24, 2.24, and 0.56 kg-ha-l, respectively). Other herbicides used for p

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47

Xue, Dong, Zhi-Gao Huang, Kimberley Barnes, Howard J. Lesiuk, Karen E. Smith, and Alastair M. Buchan. "Delayed Treatment with AMPA, but Not NMDA, Antagonists Reduces Neocortical Infarction." Journal of Cerebral Blood Flow & Metabolism 14, no. 2 (1994): 251–61. http://dx.doi.org/10.1038/jcbfm.1994.32.

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We tested the abilities of two potent non- N-methyl-d-aspartate (non-NMDA) glutamate antagonists [2,3-dihydroxy-6-nitro-7-sulfamoylbenzo( F)quinoxaline (NBQX)] and [1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5 H-2,3-benzodiazepine hydrochloride (GYKI 52466)] to reduce neocortical infarction following 2 h of transient middle cerebral artery occlusion in a hypertensive stroke model in the rat and compared these effects against, and in combination with, a potent NMDA antagonist [(+)-5-methyl-10,11-dihydro-5 H-dibenzo-[ a,d]cyclohepten-5,10-amine maleate (MK-801)]. In Expt. 1, an already estab

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48

Stella, Salvatore L., Eric J. Bryson, and Wallace B. Thoreson. "A2 Adenosine Receptors Inhibit Calcium Influx Through L-Type Calcium Channels in Rod Photoreceptors of the Salamander Retina." Journal of Neurophysiology 87, no. 1 (2002): 351–60. http://dx.doi.org/10.1152/jn.00010.2001.

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Presynaptic inhibition is a major mechanism for regulating synaptic transmission in the CNS and adenosine inhibits Ca2+ currents ( I Ca) to reduce transmitter release at several synapses. Rod photoreceptors possess L-type Ca2+ channels that regulate the release ofl-glutamate. In the retina, adenosine is released in the dark when l-glutamate release is maximal. We tested whether adenosine inhibits I Ca and intracellular Ca2+ increases in rod photoreceptors in retinal slice and isolated cell preparations. Adenosine inhibited both I Ca and the [Ca2+]i increase evoked by depolarization in a dose-d

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Todd, Keith J., Carrie A. B. Slatter, and Declan W. Ali. "Activation of Ionotropic Glutamate Receptors on Peripheral Axons of Primary Motoneurons Mediates Transmitter Release at the Zebrafish NMJ." Journal of Neurophysiology 91, no. 2 (2004): 828–40. http://dx.doi.org/10.1152/jn.00599.2003.

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The development and function of the vertebrate neuromuscular junction (NMJ) is continually being redefined. Previous studies have indicated that glutamate may play a role in the development or function of the NMJ by associating with presynaptic receptors. We have used larval zebrafish ( Danio rerio) to investigate the presence of presynaptic ionotropic glutamate receptors (iGluRs) at the NMJ in vivo. In whole-mount zebrafish larvae, antibody staining directed to NR2A subunits colocalized with specific staining of motoneuron axon tracts. Whole cell voltage-clamp recordings of miniature endplate

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50

Poolos, Nicholas P. "Hypoxia Results in GABAergic Channelopathy." Epilepsy Currents 5, no. 6 (2005): 234–35. http://dx.doi.org/10.1111/j.1535-7511.2005.00073.x.

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AMPA/Kainate Receptor–mediated Downregulation of GABAergic Synaptic Transmission by Calcineurin after Seizures in the Developing Rat Brain Sanchez RM, Dai W, Levada RE, Lippman JJ, Jensen FE J Neurosci 2005;25:3442–3451 Hypoxia is the most common cause of perinatal seizures and can be refractory to conventional anticonvulsant drugs, suggesting an age-specific form of epileptogenesis. A model of hypoxia-induced seizures in immature rats reveals that seizures result in immediate activation of the phosphatase calcineurin (CaN) in area CA1 of hippocampus. After seizures, CA1 pyramidal neurons exhi

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