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Relevant bibliographies by topics / 4-aminoquinoline

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Academic literature on the topic '4-aminoquinoline'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "4-aminoquinoline"

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Nqoro, Xhamla, and Blessing A. Aderibigbe. "4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials." Recent Patents on Anti-Infective Drug Discovery 15, no. 2 (2020): 157–72. http://dx.doi.org/10.2174/1574891x15666200804160322.

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Background: Malaria is a deadly disease. It is mostly treated using 4- aminoquinoline derivatives such as chloroquine etc. because it is well-tolerated, displays low toxicity, and after administration, it is rapidly absorbed. The combination of 4-aminoquinoline with other classes of antimalarial drugs has been reported to be an effective approach for the treatment of malaria. Furthermore, some patents reported hybrids 4-aminoquinolines containing ferrocene moiety with potent antimalarial activity. Objective: The objective of the current study is to prepare 4-aminoquinoline-ferrocene hybrids vi

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Lokaj, Jan, Viktor Kettmann, Petra Černuchová, Viktor Milata, and Marek Fronc. "3-Acetyl-4-aminoquinoline." Acta Crystallographica Section E Structure Reports Online 63, no. 3 (2007): o1164—o1166. http://dx.doi.org/10.1107/s1600536807004746.

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The title compound, C11H10N2O, a potential antitumour drug, crystallizes with two molecules in the asymmetric unit. The 4-amino N atom is strongly conjugated with the quinoline ring involving the 3-carbonyl group. As a result, the molecule is almost planar. The amino group is involved in both intramolecular N—H...O and intermolecular N—H...N hydrogen bonds.

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Sáenz, Fabián E., Tina Mutka, Kenneth Udenze, Ayoade M. J. Oduola, and Dennis E. Kyle. "Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of PlasmodiumIn VivoandIn Vitro." Antimicrobial Agents and Chemotherapy 56, no. 9 (2012): 4685–92. http://dx.doi.org/10.1128/aac.01061-12.

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ABSTRACTNew drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity. This was the case with chloroquine (CQ), a 4-aminoquinoline drug used for the prevention and treatment of malaria. However, since the 1960s,Plasmodium falciparumresistance to this drug has spread globally, and more recently, emerging resistance to CQ byPlasmodium vivaxthreatens the health of 70 to 320 million people annually. Despite the emergence of CQ resistance, synthetic quinoline derivatives remain validated leads for

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Dolengovski, Egor L., Tatyana V. Gryaznova, Oleg G. Sinyashin, Elena L. Gavrilova, Kirill V. Kholin, and Yulia H. Budnikova. "Morpholine Radical in the Electrochemical Reaction with Quinoline N-Oxide." Catalysts 13, no. 9 (2023): 1279. http://dx.doi.org/10.3390/catal13091279.

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An electrochemical reaction between quinoline N-oxides and morpholine was developed by using Cu(OAc)2 as a catalyst, generating products of 4-aminoquinoline N-oxides in CH2Cl2 or 2-aminoquinoline N-oxides in CH3CN in good yields. With an increase in the amount of electricity passed, the product deoxygenates with the formation of aminoquinolines. The advantages of the reaction are mild conditions, room temperature, the use of morpholine rather than its derivatives, and the ability to control the process when the electrolysis conditions change. Bisubstituted quinoline has also been obtained. The

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Opsenica, Igor, Kirsten Smith, Lucia Gerena, Sandra Gaica, and Bogdan Solaja. "Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores." Journal of the Serbian Chemical Society 73, no. 11 (2008): 1021–25. http://dx.doi.org/10.2298/jsc0811021o.

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Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).

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Hadanu, Ruslin, Chairil Anwar, Jumina Jumina, Iqmal Tahir, and Mustofa Mustofa. "SYNTHESIS OF ANTIMALARIAL 3-(2-HYDROXYETHYL)-2-METHYL-1,10-PHENANTHROLINE-4-OL FROM 8-AMINOQUINOLINE." Indonesian Journal of Chemistry 4, no. 2 (2010): 82–87. http://dx.doi.org/10.22146/ijc.21858.

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It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2) cyclization of the resulted 3-[1-(quinolin-8-ylamino)-ethylidene]-4,5-dihydro-furan-2-one. The reaction of 8-aminoquinoline with 2-acetyl-butyrolactone was performed in toluene at reflux for 6 hours in the presence of p-toluensulfonic acid as catalyst. This reaction gave 3-[1-(quinolin-8-ilamino)-

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Médebielle, Maurice, Stéphane Hohn, Etsuji Okada, Hidehiko Myoken, and Dai Shibata. "Synthesis of novel fluorinated 4-aminoquinoline derivatives." Tetrahedron Letters 46, no. 45 (2005): 7817–21. http://dx.doi.org/10.1016/j.tetlet.2005.09.018.

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Vaiana, Nadia, Melissa Marzahn, Silvia Parapini, et al. "Antiplasmodial activities of 4-aminoquinoline–statine compounds." Bioorganic & Medicinal Chemistry Letters 22, no. 18 (2012): 5915–18. http://dx.doi.org/10.1016/j.bmcl.2012.07.069.

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Antinarelli, Luciana M. R., Rafael M. P. Dias, Isabela O. Souza, et al. "4-Aminoquinoline Derivatives as Potential Antileishmanial Agents." Chemical Biology & Drug Design 86, no. 4 (2015): 704–14. http://dx.doi.org/10.1111/cbdd.12540.

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Yunnikova, L. P., Yu E. Likhareva, and V. V. Esenbaeva. "Electrophilic Tropylation of Aminopyridines and 4-Aminoquinoline." Russian Journal of General Chemistry 89, no. 9 (2019): 1927–30. http://dx.doi.org/10.1134/s1070363219090305.

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Dissertations / Theses on the topic "4-aminoquinoline"

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Shone, Alison Emily. "The synthesis and metabolism of novel 4-aminoquinoline antimalarials." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443926.

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Fortuin, Elton E. "Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents." University of the Western Cape, 2014. http://hdl.handle.net/11394/4463.

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Magister Pharmaceuticae - MPharm<br>Plasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was the mainstay aminoquinoline derived chemotherapeutic agent that has been used for many years against blood-stage malaria. However, today the control of malaria has been complicated by increased resistance of the malaria parasite to existing antimalarial agents such as CQ. The primary cause of resistance is mutation in a putative ATP-powered

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Melo, Candice Soares de. "Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/6334.

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Includes bibliographical references.<br>The work presented in this thesis is two-fold: (i) development of single agents that provide inhibition of both the growth of malaria parasites and of tumour cells in vitro, and (ii) inclusion of these potential novel inhibitors in cyclodextrin host molecules in an attempt to render these dual drugs water-soluble. Of all the current clinically established antimalarials, the 4-aminoquinolines haveproven to be the most significant and efficacious for the treatment and prophylaxis of malaria. However, their efficacy has decreased by the spread of drug resis

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Hawley, Shaun Richard. "Studies on the chemical and physicochemical basis of 4-aminoquinoline accumulation, activity and resistance in Plasmodium falciparum malaria." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309903.

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Andayi, Warren Andrew. "Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/14824.

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Includes abstract.<br>With the aim of designing appropriate hybrid molecules as a strategy to fight drug resistant malaria parasites, 4-aminoquinoline-3,4-hydroxypyridinone hybrids were designed and synthesized. Their hypothesized mode of action was studied with respect to inhibition of hemozoin formation.

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Liebman, Katherine May. "New 4-Aminoquinoline Compounds to Reverse Drug Resistance in P. falciparum Malaria, and a Survey of Early European Antimalarial Treatments." PDXScholar, 2014. http://pdxscholar.library.pdx.edu/open_access_etds/2114.

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Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity agains

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Mabotha, Tebogo E. "Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/6326.

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Includes bibliographical references (leaves 178-191).<br>An interfacial method was developed in order to investigate the role lipids might play in haemozoin biosynthesis. Infrared and X-ray diffraction measurements demonstrated that β-haematin, a synthetic counterpart of haemozoin, forms efficiently at pentanol/water, octanol/water and lipid/water interfaces, but to a lesser extent at toluene/water interface under physiological conditions of pH and temperature and does not form at all in the absence of the interface.

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Antinarelli, Luciana Maria Ribeiro. "Atividade leishmanicida de derivados de quinolinas: 4-aminoquinolinas complexadas a esteroide e amodiaquina." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5289.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-06-21T15:25:14Z No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b172b6f3cf (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-07T19:10:52Z (GMT) No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b172b6f3cf (MD5)<br>Made available in DSpace on 2017-08-07T19:10:52Z (GMT). No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b

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Souza, Isabela de Oliveira. "Síntese de derivados aminoquinolínicos e avaliação do efeito em protozoários." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/4655.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-05-25T14:41:06Z No. of bitstreams: 1 isabeladeoliveirasouza.pdf: 8840752 bytes, checksum: de1f7daf9c0f6025ccc57475de168c79 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-25T14:48:39Z (GMT) No. of bitstreams: 1 isabeladeoliveirasouza.pdf: 8840752 bytes, checksum: de1f7daf9c0f6025ccc57475de168c79 (MD5)<br>Made available in DSpace on 2017-05-25T14:48:39Z (GMT). No. of bitstreams: 1 isabeladeoliveirasouza.pdf: 8840752 bytes, checksum: de1f7daf9c0f6025ccc57475de168c79 (MD5) Previ

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Antinarelli, Luciana Maria Ribeiro. "Estudos in vitro, in vivo e in silico da atividade de derivados aminoquinolínicos em espécies de Leishmania relacionadas à Leishmaniose tegumentar americana." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5599.

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Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-08-17T11:16:52Z No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 16756474 bytes, checksum: 2304892df326fd4997c78bc7f0870bae (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-17T11:34:54Z (GMT) No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 16756474 bytes, checksum: 2304892df326fd4997c78bc7f0870bae (MD5)<br>Made available in DSpace on 2017-08-17T11:34:54Z (GMT). No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 16756474 bytes, checksum: 230

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Book chapters on the topic "4-aminoquinoline"

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Cutler, D. J., A. C. MacIntyre, and S. E. Tett. "Pharmacokinetics and Cellular Uptake of 4-Aminoquinoline Antimalarials." In Basis for Variability of Response to Anti-Rheumatic Drugs. Birkhäuser Basel, 1988. http://dx.doi.org/10.1007/978-3-0348-9160-8_13.

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Kumar, Deepak, Beena Negi, and Diwan S. Rawat. "Diverse Pharmacological Activities of 4-Aminoquinoline and its Derivatives." In Recent Advances in Pharmaceutical Innovation and Research. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2302-1_10.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex of Schiff base derived from 8-aminoquinoline and 2, 4-dihydroxybenzaldehyde." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_230.

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Bentley, P. D., F. Earley, R. J. Fletcher, et al. "4-Aminoquinolines as AChE Inhibitors." In Structure and Function of Cholinesterases and Related Proteins. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-1540-5_65.

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Browning, David J. "Clinical Examples in Managing Patients Taking 4-Aminoquinolines." In Hydroxychloroquine and Chloroquine Retinopathy. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_10.

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O’Neill, Paul M., Victoria E. Barton, Stephen A. Ward, and James Chadwick. "4-Aminoquinolines: Chloroquine, Amodiaquine and Next-Generation Analogues." In Treatment and Prevention of Malaria. Springer Basel, 2011. http://dx.doi.org/10.1007/978-3-0346-0480-2_2.

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Allen, Stephen, and Divya Tiwari. "Determination of a Possible Benefit of 4-Aminoquinoline Drugs to Reset Post-Acute Inflammation in Old Age." In Recent Developments in Medicine and Medical Research Vol. 7. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/rdmmr/v7/4559f.

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Tijjani, Habibu, Ahmed Olatunde, Adegbenro Peter Adegunloye, and Ahmed Adebayo Ishola. "In silico insight into the interaction of 4-aminoquinolines with selected SARS-CoV-2 structural and nonstructural proteins." In Coronavirus Drug Discovery. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-95578-2.00001-7.

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Conference papers on the topic "4-aminoquinoline"

1

Ikhmais, Balqis A., Buthaina Hussein, Ian Stratford, Sally Freeman, and Joaana Neill. "Abstract 3007: Evaluating novel 4-aminoquinoline inhibitors of NQO2 in ovarian cancer." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3007.

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Reports on the topic "4-aminoquinoline"

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Liebman, Katherine. New 4-Aminoquinoline Compounds to Reverse Drug Resistance in P. falciparum Malaria, and a Survey of Early European Antimalarial Treatments. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2112.

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