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Journal articles on the topic '4-d]pyridazine'

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Published: 4 June 2021

Last updated: 8 February 2022

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1

Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, form

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2

Chmovzh, Knyazeva, mlv@ioc ac ru Tanaka та ін. "[1,2,5]Thiadiazolo[3,4-d]Pyridazine as an Internal Acceptor in the D-A-π-A Organic Sensitizers for Dye-Sensitized Solar Cells". Molecules 24, № 8 (2019): 1588. http://dx.doi.org/10.3390/molecules24081588.

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Four new D-A-π-A metal-free organic sensitizers for dye-sensitized solar cells (DSSCs), with [1,2,5]thiadiazolo[3 ,4-d]pyridazine as internal acceptor, thiophene unit as π-spacer and cyanoacrylate as anchoring electron acceptor, have been synthesized. The donor moiety was introduced into [1,2,5]thiadiazolo[3,4-d]pyridazine by nucleophilic aromatic substitution and Suzuki cross-coupling reactions, allowing design of D-A-π-A sensitizers with the donor attached to the internal heterocyclic acceptor not only by the carbon atom, as it is in a majority of DSSCs, but by the nitrogen atom also. Althou

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3

Richter, Marianne, та Gunther Seitz. "4-(β-D-Ribofuranosyl)pyridazine: Neue C-Nukleoside durch [4+2]-Cycloaddition mit inversem Elektronenbedarf". Archiv der Pharmazie 327, № 6 (1994): 365–70. http://dx.doi.org/10.1002/ardp.19943270604.

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4

Bussolari, Jacqueline C., Johanna D. Stoeckler, and Raymond P. Panzica. "The synthesis and biological evaluation of 4-p-nitrobenzylthio-v-triazolo [4,5-d]pyridazine and imidazo[4,5-d]pyridazine ribosides as potential nucleoside transport inhibitors." Bioorganic & Medicinal Chemistry 4, no. 10 (1996): 1725–31. http://dx.doi.org/10.1016/0968-0896(96)00188-5.

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5

Ramesh, Kakarla, and Raymond Panzica. "Synthesis and Biological Activity of Certain 4-Substituted Imidazo[4,5-d]Pyridazine Nucleosides." Nucleosides, Nucleotides and Nucleic Acids 8, no. 5 (1989): 1141–42. http://dx.doi.org/10.1080/07328318908054311.

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6

Filali, Mouad, Nada Kheira Sebbar, Tuncer Hökelek, et al. "Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of 4-[(prop-2-en-1-yloxy)methyl]-3,6-bis(pyridin-2-yl)pyridazine." Acta Crystallographica Section E Crystallographic Communications 75, no. 9 (2019): 1321–26. http://dx.doi.org/10.1107/s2056989019011186.

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The title compound, C18H16N4O, consists of a 3,6-bis(pyridin-2-yl)pyridazine moiety linked to a 4-[(prop-2-en-1-yloxy)methyl] group. The pyridine-2-yl rings are oriented at a dihedral angle of 17.34 (4)° and are rotated slightly out of the plane of the pyridazine ring. In the crystal, C—HPyrd...NPyrdz (Pyrd = pyridine and Pyrdz = pyridazine) hydrogen bonds and C—HPrpoxy...π (Prpoxy = prop-2-en-1-yloxy) interactions link the molecules, forming deeply corrugated layers approximately parallel to the bc plane and stacked along the a-axis direction. Hirshfeld surface analysis indicates that the mos

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7

Chmovzh, Timofey N., and Oleg A. Rakitin. "7-Bromo-[1,2,5]selenadiazolo[3,4-d]pyridazin-4(5H)-one." Molbank 2021, no. 2 (2021): M1229. http://dx.doi.org/10.3390/m1229.

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New heterocyclic systems containing 1,2,5-chalcogenadiazoles are of great interest for the creation of organic photovoltaic materials and biologically active compounds. In this communication, 3,6-dibromopyridazine-4,5-diamine was investigated in reaction with selenium dioxide in order to obtain 4,7-dibromo-[1,2,5]selenadiazolo[3,4-d]pyridazine. We found that 7-bromo-[1,2,5]selenadiazolo[3,4-d]pyridazin-4(5H)-one, the first representative of the new heterocyclic system, was isolated as a hydrolysis product of the corresponding 4,7-dibromoderivative. The structure of the newly synthesized compou

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8

Patra, Gopal Chandra, Sankar Chandra Bhunia, Monoj Kumar Roy, and Sudhir Chandra Pal. "Synthesis of 4-Aryl-4,6-dihydropyrimido[4,5-d]pyridazine-2,5(1H,3H)-diones fromBiginelliCompounds." Helvetica Chimica Acta 96, no. 1 (2013): 130–34. http://dx.doi.org/10.1002/hlca.201200109.

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9

Chen, Shi-Quan, Kai Jiang, and Shi-Fan Wang. "Ethyl 3-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[2,3-d]pyridazine-2-carboxylate." Acta Crystallographica Section E Structure Reports Online 66, no. 2 (2010): o259. http://dx.doi.org/10.1107/s1600536809055081.

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10

OISHI, ETSUO, HIDEKI MATSUBARA, and EISAKU HAYASHI. "Condensed Pyridazines. III. Reaction of 4, 7-Dichloro-1-phenyl-1H-pyrazolo [3, 4-d] pyridazine with Carbanions." YAKUGAKU ZASSHI 105, no. 2 (1985): 119–28. http://dx.doi.org/10.1248/yakushi1947.105.2_119.

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11

Abdelhamid, Abdou O., Zeineb H. Ismail, and Anhar Abdel-Aziem. "Reactions with Hydrazonoyl Halides 601: Synthesis of Thieno[2′,3′:4,5] Pyrimidino[1,2-b][1,2,4,5]tetrazines, [1]benzothieno[2′,3′:4,5]pyrimidino [1,2-b][1,2,4,5]tetrazines, Pyrazolo[3′,4′:4,5]pyrimidino[1,2-b] [1,2,4,5]tetrazines and Pyrazolo[3,4-d]pyridazines." Journal of Chemical Research 2007, no. 10 (2007): 609–16. http://dx.doi.org/10.3184/030823407x256118.

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Thieno[2′,3′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, [1]benzothieno-[2′,3′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, pyrazolo [3′,4′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, triazolo[4,3- a]pyrimidin-5(1 H)-one, 1-{[2-(1-benzofuran-2-yl)-5-phenyl-4,5-dihydro-1 H-pyrazol-1-yl]-4-substituted-1,3-thiazol-5-yl}-2-phenyldiazene, 3-acyl-4-(1-benzofuran-2-ylcarbonyl) pyrazole and pyrazolo[3,4- d]pyridazine derivatives could be obtained via reactions of hydrazonoyl halides with the appropriate pyrimidine-2-thione, 3-amino-5,6-dimethyl-2-sulfanylthieno[2,3- d]pyrimidin-4(3 H)-one, 5-amino-6-mercapto

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12

Daoui, Said, Cemile Baydere, Fouad El Kalai, et al. "Crystal structure, Hirshfeld surface analysis and DFT studies of 2-[5-(4-methylbenzyl)-6-oxo-3-phenyl-1,6-dihydropyridazin-1-yl]acetic acid." Acta Crystallographica Section E Crystallographic Communications 75, no. 12 (2019): 1925–29. http://dx.doi.org/10.1107/s2056989019015317.

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The title pyridazinone derivative, C20H18N2O3, is not planar. The phenyl ring and the pyridazine ring are inclined to each other by 10.55 (12)°, whereas the 4-methylbenzyl ring is nearly orthogonal to the pyridazine ring, with a dihedral angle of 72.97 (10)°. In the crystal, molecules are linked by pairs of O—H...O hydrogen bonds, forming inversion dimers with an R 2 2(14) ring motif. The dimers are linked by C—H...O hydrogen bonds, generating ribbons propagating along the c-axis direction. The intermolecular interactions were additionally investigated using Hirshfeld surface analysis and two-

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13

Annam, Sri Charitha, K. V. Padmavathi, N. Murali Krishna, and Mannam Subbarao. "Computational Designing of Low Energy Band Gap of New Donor-Acceptor (D-A) Copolymer Monomers for Organic Solar Cells: DFT and TD-DFT Study." Science & Technology Journal 8, no. 2 (2020): 44–54. http://dx.doi.org/10.22232/stj.2020.08.02.08.

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Via this look at efforts have been made to increase a chain of latest donor-acceptor (D-A) systems through the usage of 4-methoxy-2,7,nine-trimethyl-9H-carbazole (2,7-MMCB) as a electron donor and benzo[c][1,2,5] oxadiazole (BCO); benzo[c] [1,2,5] thiadiazole (BCT); benzo[c][1,2,5]selenadiazole (BCS); [1,2,5]oxadiazolo[3,4-c]pyridine (OCP); [1,2,5] thiadiazolo [3,4-c]pyridine (TCP); [1,2,5] selenadiazolo [3,4-c]pyridine (SCP); [1,2,5] oxadiazolo[3,4-d]pyridazine (ODP); [1,2,5] thiadiazolo[3,4-d]pyridazine (TDP) as electron acceptors. In this work, we executed calculations of DFT and TD-DFT/B3L

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14

Renoud-Grappin, M., C. Fossey, G. Fontaine, D. Ladurée, AM Aubertin, and A. Kirn. "Imidazo[1,5-b]Pyridazine-D4T Conjugates: Synthesis and Anti-Human Immunodeficiency Virus Evaluation." Antiviral Chemistry and Chemotherapy 9, no. 3 (1998): 205–23. http://dx.doi.org/10.1177/095632029800900302.

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In an attempt to combine the human immunodeficiency virus type 1 (HIV-D-inhibitory capacity of 2′,3 -dideoxy-2,3 -didehydronucleoside analogues [nucleoside reverse transcriptase (RT) inhibitors; NRTI] and non-nucleoside RT inhibitors (NNRTI), we have designed, synthesized and evaluated for their anti-HIV activity several heterodimers of the general formula [d4T]-NH-(CH2)n-NH-[imidazo[1,5–b]pyridazine]. The synthesis of these heterodimers was conducted in three parts. The first part focused on the synthesis of the NRTI. The second part was devoted to the NNRTI and the NNRTI linked to appropriat

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15

Tominaga, Yoshinori, Noriko Yoshioka, Hiroki Minematsu, and Seigo Kataoka. "Synthesis and Chemiluminescence of 1,3-Disubstituted 4-Hydroxypyrazolo[4',3':5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-diones." HETEROCYCLES 44, no. 1 (1997): 85. http://dx.doi.org/10.3987/com-96-s17.

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16

Haider, Norbert, Kurt Mereiter, and Richard Wanko. "[4+2]Cycloaddition Reactions of 1,4-Bis(trifluoromethyl)pyrido[3,4-d]pyridazine with Indole-Type Dienophiles." HETEROCYCLES 41, no. 7 (1995): 1445. http://dx.doi.org/10.3987/com-95-7063.

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17

OISHI, ETSUO, TAKESHI ENDO, YOSHIKAZU ASAHINA, and EISAKU HAYASHI. "Condensed Pyridazines. IV. Chemical Properties of 7-Methoxy-1-phenyl-1H-pyrazolo [3, 4-d] pyridazine 5-Oxide." YAKUGAKU ZASSHI 105, no. 2 (1985): 129–41. http://dx.doi.org/10.1248/yakushi1947.105.2_129.

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18

Meade, Eric A., та Leroy B. Townsend. "Synthesis of 4-Amino-1-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyridazine; an entry into a novel series of adenosine analogs". Bioorganic & Medicinal Chemistry Letters 1, № 2 (1991): 111–14. http://dx.doi.org/10.1016/s0960-894x(00)80242-5.

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19

Al-Mehizia, Abdulrahman A., Ahmed H. Bakheit, Seema Zargar, Mashooq A. Bhat, Majid Mohammed Asmari, and Tanveer A. Wani. "Evaluation of Biophysical Interaction between Newly Synthesized Pyrazoline Pyridazine Derivative and Bovine Serum Albumin by Spectroscopic and Molecular Docking Studies." Journal of Spectroscopy 2019 (June 16, 2019): 1–12. http://dx.doi.org/10.1155/2019/3848670.

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In this research, the pyrazoline pyridazine derivative 7-methyl-2-phenyl-4-(3,4,5-trimethoxyphenyl)-2H-pyrazolo[3,4-d]pyridazine (5d) was studied for its interaction with bovine serum albumin (BSA). Various spectroscopic techniques along with molecular docking analysis were utilized to understand the mechanism of interaction. The quenching of BSA fluorescence by using investigational drug 5d was the basic principle for the methodology. Spectrofluorometric methods and UV-absorption studies were conducted for exploration of the 5d and BSA binding mechanism. The fluorescence quenching mechanism i

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20

TOMINAGA, Y., N. YOSHIOKA, H. MINEMATSU, and S. KATAOKA. "ChemInform Abstract: Synthesis and Chemiluminescence of 1,3-Disubstituted 4-Hydroxypyrazolo( 4′,3′:5,6)pyrido(2,3-d)pyridazine-5,8(6H,7H)diones." ChemInform 28, no. 21 (2010): no. http://dx.doi.org/10.1002/chin.199721163.

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21

THEOCHARIS, A. B., N. E. ALEXANDROU, and A. TERZIS. "ChemInform Abstract: Generation and Dienophilic Properties of 1-Benzyl-1H-1,2,3-triazolo(4, 5-d)pyridazine-4,7-dione." ChemInform 22, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199111204.

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22

Patra, Gopal Chandra, Sankar Chandra Bhunia, Monoj Kumar Roy, and Sudhir Chandra Pal. "ChemInform Abstract: Synthesis of 4-Aryl-4,6-dihydropyrimido[4,5-d]pyridazine-2,5(1H,3H)-diones from Biginelli Compounds." ChemInform 44, no. 22 (2013): no. http://dx.doi.org/10.1002/chin.201322183.

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23

Quintela, J. M., M. C. Veiga, R. Alvarez-Sarand�s, L. Gonz�lez, and C. Peinador. "Synthesis of new pyridazino[4?,3?:4,5]-thieno[3,2-d]-1,2,3-triazine and pyrimido[4?,5?:4,5]thieno[2,3-c]pyridazine derivatives." Monatshefte f�r Chemie Chemical Monthly 127, no. 10 (1996): 1037–43. http://dx.doi.org/10.1007/bf00807576.

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24

MEADE, E. A., та L. B. TOWNSEND. "ChemInform Abstract: Synthesis of 4-Amino-1-(β-D-ribofuranosyl)pyrrolo(2,3-d)pyridazine. An Entry into a Novel Series of Adenosine Analogs." ChemInform 22, № 35 (2010): no. http://dx.doi.org/10.1002/chin.199135262.

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25

Pita, Beatriz, Eddy Sotelo, Margarita Suárez, et al. "Pyridazine Derivatives. Part 21: Synthesis and Structural Study of Novel 4-Aryl-2,5-dioxo-8-phenylpyrido[2,3-d]pyridazines." Tetrahedron 56, no. 16 (2000): 2473–79. http://dx.doi.org/10.1016/s0040-4020(00)00082-x.

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26

Deeb, Ali, Mahmoud Kotb, and Mohamed El-Abbasy. "Pyridazine Derivatives and Related Compounds, Part 12: Synthesis of Some Pyridazino [4′,3′:4,5]thieno[3,2-d]1,2,3-triazines." Phosphorus, Sulfur, and Silicon and the Related Elements 180, no. 2 (2005): 591–99. http://dx.doi.org/10.1080/104265090517398.

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27

Amer, F. A., M. Hammouda, A. A. S. El-Ahl, and B. F. Abdel-Wahab. "Synthesis of new pyrrolo-[3,4-c]isoxazole, pyrrolo[2,3-d]-[1,2,3]triazole, triazolo[4,5-c]-pyridazine, and dipyrrolo-[3,2-b:3′,4′-d]pyran derivatives." Chemistry of Heterocyclic Compounds 43, no. 12 (2007): 1559–66. http://dx.doi.org/10.1007/s10593-007-0241-4.

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28

QUINTELA, J. M., M. C. VEIGA, R. ALVAREZ-SARANDES, L. GONZALEZ, and C. PEINADOR. "ChemInform Abstract: Synthesis of New Pyridazino(4′,3′:4,5)thieno(3,2-d)-1,2,3-triazine and Pyrimido(4′,5′:4,5)thieno(2,3-c)pyridazine Derivatives." ChemInform 28, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199712151.

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29

Tominaga, Yoshinori, Noriko Yoshioka, Seigo Kataoka, Norihito Aoyama, Toshiyuki Masunari, and Akira Miike. "Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyridazine-5,8(6h,7h)-diones and related compounds." Tetrahedron Letters 36, no. 47 (1995): 8641–44. http://dx.doi.org/10.1016/0040-4039(95)01862-c.

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30

Pita, Beatriz, Eddy Sotelo, Margarita Suarez, et al. "ChemInform Abstract: Pyridazine Derivatives. Part 21. Synthesis and Structural Study of Novel 4-Aryl-2,5-dioxo-8-phenylpyrido[2,3-d]pyridazines." ChemInform 31, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.200030131.

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31

Haider, Norbert, Kurt Mereiter, and Richard Wanko. "Inverse-Electron-Demand Diels-Alder Reactions of Condensed Pyridazines, 4. Synthesis and Cycloaddition Reactions of 1,4-Bis(trifluoromethyl)pyrido[3,4-d]pyridazine." HETEROCYCLES 38, no. 8 (1994): 1845. http://dx.doi.org/10.3987/com-94-6753.

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32

Abdel-Rehem, Esam, and Norbert Haider. "Unsubstituted pyrido[3,4-d]pyridazine as an electron-deficient azadiene in [4+2] cycloaddition reactions: a short route to g-fused isoquinolines." Arkivoc 2001, no. 2 (2001): 21–27. http://dx.doi.org/10.3998/ark.5550190.0002.203.

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33

Meade, Eric A., Linda L. Wotring, John C. Drach, and Leroy B. Townsend. "Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogs." Journal of Medicinal Chemistry 35, no. 3 (1992): 526–33. http://dx.doi.org/10.1021/jm00081a014.

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34

Deeb, Ali, and Mohamed El-Abbasy. "Pyridazine Derivatives and Related Compounds, Part 21:1 Synthesis of Different Heterocycles from 2-Methyl-4H- pyridazino[4′,3′:4,5]thieno[3,2-d]-1,3-oxazin-4-one." Phosphorus, Sulfur, and Silicon and the Related Elements 181, no. 1 (2006): 15–23. http://dx.doi.org/10.1080/104265090968451.

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35

Wang, Ke, Xiao-long Fu, Qiu-fan Tang, et al. "Theoretical investigations on novel energetic salts composed of 4-nitro-7-(4-nitro-1,2,3-triazol-1-olate)-furazano[3,4-d]pyridazine-based anions and ammonium-based cations." Computational Materials Science 146 (April 2018): 230–39. http://dx.doi.org/10.1016/j.commatsci.2018.01.016.

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36

Merslavič, Marjo, Andrej Petrič, Branko Stanovnik, and Miha Tišler. "1, 3-dipolar cycloaddition of diazomethane to azolopyridazines. The synthesis of 8-methyl-8H- and 9-methyl-9H-pyrazolo[3, 4-d]-s-triazolo[4, 3-b]pyridazine and 1-methyl-1H- and 2-methyl-2H-imidazo[1, 2-b]pyrazolo[3, 4-b]pyridazine derivatives." Journal of Heterocyclic Chemistry 26, no. 3 (1989): 581–83. http://dx.doi.org/10.1002/jhet.5570260311.

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37

Zohdi, Hussein F., Tabia A. Osman, and Abdou O. Abdelhamid. "Heterocycles from Pyrazoloylhydroximoyl Chloride: Synthesis of Certain Quinoxaline, Benzothiadiazine, Benzoxadiazine, Quinazolinone, Imidazo[1,2-a]pyridine, Imidazo[1,2-a]pyrimidine, Isoxazole, Pyrazolo[3,4-d]pyridazine and Pyrrolidino[3,4-d]isoxazolin-4,." Journal of the Chinese Chemical Society 44, no. 6 (1997): 617–23. http://dx.doi.org/10.1002/jccs.199700095.

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38

MEADE, E. A., L. L. WOTRING, J. C. DRACH, and L. B. TOWNSEND. "ChemInform Abstract: Synthesis, Antiproliferative, and Antiviral Activity of Certain 4-Aminopyrrolo(2,3-d)pyridazine Nucleosides: An Entry into a Novel Series of Adenosine Analogues." ChemInform 23, no. 23 (2010): no. http://dx.doi.org/10.1002/chin.199223266.

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39

TOMINAGA, Y., N. YOSHIOKA, S. KATAOKA, N. AOYAMA, T. MASUNARI, and A. MIIKE. "ChemInform Abstract: Synthesis and Chemiluminescence of 1,3-Disubstituted Pyrazolo(4′,3′:5, 6)pyrido(2,3-d)pyridazine-5,8(6H,7H)-diones and Related Compounds." ChemInform 27, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199612172.

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40

Zohdi, Hussein F., Rafat M. Mohareb, and Wagnat W. Wardakhan. "HETEROCYCLIC SYNTHESIS WITH ISOTHIOCYANATE AND SULFUR: A NOVEL ROUTE FOR THE SYNTHESIS OF PYRIDINO[2,3-d]THIAZOLE, THIAZOLO[4′,5′:2,3] PYRIDINO[4,3-d]PYRIDAZINE AND THIAZOLO[4,5-b]ISOQUINOLINE DERIVATIVES." Phosphorus, Sulfur, and Silicon and the Related Elements 101, no. 1-4 (1995): 179–87. http://dx.doi.org/10.1080/10426509508042515.

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41

HAIDER, N., K. MEREITER, and R. WANKO. "ChemInform Abstract: Inverse-Electron-Demand Diels-Alder Reactions of Condensed Pyridazines, Part 4. Synthesis and Cycloaddition Reactions of 1,4-Bis( Trifluoromethyl)pyrido(3,4-d)pyridazine." ChemInform 25, no. 46 (2010): no. http://dx.doi.org/10.1002/chin.199446175.

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42

Boraei, Ahmed T. A., Ahmed A. M. Sarhan, Sammer Yousuf, and Assem Barakat. "Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline." Molecules 25, no. 3 (2020): 450. http://dx.doi.org/10.3390/molecules25030450.

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A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(1H-indol-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 1 with aromatic aldehydes controlled the final product. Reflux in glacial acetic acid yielded Schiff bases 2–6, whereas concentrated HCl in ethanol resulted in a cyclization product at C-3 of the indole ring to create indolo-triazolo-pyridazinethiones 7–16. This fascinating cyclization appr

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KOERMENDY, K., and F. RUFF. "ChemInform Abstract: Pyridazines Condensed with a Hetero Ring. Part 4. Formation of Pyrazino(2,3-d(c))pyridazine Skeletons by Cyclocondensation of 4,5- Diamino- and 3,4,5-Triaminopyridazinones." ChemInform 22, no. 15 (2010): no. http://dx.doi.org/10.1002/chin.199115196.

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Ito, Keiichi, Kazuya Kinoshita, Atsuyuki Tomizawa, et al. "Pharmacological Profile of Novel Acid Pump Antagonist 7-(4-Fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526)." Journal of Pharmacology and Experimental Therapeutics 323, no. 1 (2007): 308–17. http://dx.doi.org/10.1124/jpet.107.121350.

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TOMINAGA, Y., J. K. LUO, L. W. CASTLE, and R. N. CASTLE. "ChemInform Abstract: Polycyclic Pyridazines. Part 2. Synthesis of Pyrazolo(4′,3′:5,6)pyrido( 2,3-d)pyridazine Derivatives from Dimethyl Pyrazolo(3,4-b)pyridine-5,6- dicarboxylates as the Key Intermediates." ChemInform 24, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199338218.

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HAIDER, N., K. MEREITER, and R. WANKO. "ChemInform Abstract: Inverse-Electron-Demand Diels-Alder Reactions of Condensed Pyridazines. Part 7. (4 + 2) Cycloaddition Reactions of 1,4-Bis(trifluoromethyl) pyrido(3,4-d)pyridazine with Indole-Type Dienophiles." ChemInform 26, no. 43 (2010): no. http://dx.doi.org/10.1002/chin.199543170.

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Filali, Mouad, Hicham Elmsellem, Tuncer Hökelek, et al. "Crystal structure, Hirshfeld surface analysis and corrosion inhibition study of 3,6-bis(pyridin-2-yl)-4-{[(3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-5H-bis[1,3]dioxolo[4,5-b:4′,5′-d]pyran-5-yl)methoxy]methyl}pyridazine monohydrate." Acta Crystallographica Section E Crystallographic Communications 75, no. 8 (2019): 1169–74. http://dx.doi.org/10.1107/s2056989019009848.

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In the title compound, C27H30N4O6·H2O, the two dioxolo rings are in envelope conformations, while the pyran ring is in a twisted-boat conformation. The pyradizine ring is oriented at dihedral angles of 9.23 (6) and 12.98 (9)° with respect to the pyridine rings, while the dihedral angle between the two pyridine rings is 13.45 (10)°. In the crystal, O—Hwater...Opyran, O—Hwater...Omethoxymethyl and O—Hwater...Npyridazine hydrogen bonds link the molecules into chains along [010]. In addition, weak C—Hdioxolo...Odioxolo hydrogen bonds and a weak C—Hmethoxymethyl...π interaction complete the three-d

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Attaby, Fawzy A., Sanaa M. Eldin та Mohamed B. Abou-abdou. "REACTIONS OF α-THIOCARBOXAMIDOCINNA-MONITRILE DERIVATIVES WITH DIETHYL MALONATE: SYNTHESIS OF PYRAZOLO-[3,4-b]-α-PYRIDINONE, THIENO[2,3-b]-α-PYRIDINONE, PYRIDO[2,3:4′,5′]THIENO[2,3-c]PYRIDAZINE AND PYRIDO[2,3:4′,5′]-THIENO[2,3-d]PYRIMIDINONETHIONE DERIVATIVES". Phosphorus, Sulfur, and Silicon and the Related Elements 129, № 1 (1997): 121–33. http://dx.doi.org/10.1080/10426509708031587.

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Furlan, Borut, Branko Stanovnik, and Miha Tišler. "1,3-Dipolar Cycloadditions of 2-Diazopropane to 1-Phenyl-bis-s-triazolo[4,3-b:3′,4′-f]pyridazine. The Synthesis of 11,11-Dimethyl-11H-pyrazolo [3,4-d]bis-s-triazolo[4,3-b:3′,4′-f]pyridazines, Derivatives of a Novel Heterocyclic System." Synthesis 1986, no. 01 (1986): 78–80. http://dx.doi.org/10.1055/s-1986-31486.

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Ito, Keiichi, Kazuya Kinoshita, Atsuyuki Tomizawa, et al. "The Effect of Subchronic Administration of 7-(4-Fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526), a Novel Acid Pump Antagonist, on Gastric Acid Secretion and Gastrin Levels in Rats." Journal of Pharmacology and Experimental Therapeutics 326, no. 1 (2008): 163–70. http://dx.doi.org/10.1124/jpet.108.137299.

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