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Relevant bibliographies by topics / 4-dihydropyrimidines

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Journal articles

Academic literature on the topic '4-dihydropyrimidines'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 June 2025

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Journal articles on the topic "4-dihydropyrimidines"

1

C. Heda, L. C., Rashmi Sharma, C. Pareek, and P. B. Chaudhari. "Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines." E-Journal of Chemistry 6, no. 3 (2009): 770–74. http://dx.doi.org/10.1155/2009/893812.

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P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These results are promising, showing these compounds are biologically active.

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2

Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines." Tetrahedron 67, no. 14 (2011): 2661–69. http://dx.doi.org/10.1016/j.tet.2011.01.092.

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3

Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "Synthesis of 4-oxopyrimidinium and 4-oxo-1,4-dihydropyrimidines." Journal of Heterocyclic Chemistry 36, no. 1 (1999): 97–104. http://dx.doi.org/10.1002/jhet.5570360115.

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4

Povstyanoy, V. M., T. A. Yuyrova, A. N. Retchitskiy, and A. A. Krysko. "ALTERNATIVE METHODS OF SYNTHESIS OF NOVEL HETEROSYNTHONES – FUNCTIONALIZED HYPOXANTHINE PYRIMIDINES." Odesa National University Herald. Chemistry 26, no. 2(78) (2021): 32–39. http://dx.doi.org/10.18524/2304-0947.2021.2(78).233823.

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It has been known that derivatives of dihydropyrimidine and xanthine possess the physiological activity of the wide spectrum of action. The combination of the specified heterocyclic fragments within one molecule can lead to the increase of its known types of biological activity as well as to the discovery of novel types of activity. We have previously reported the synthesis of intermediates, which consist of functionalized dihydropyrimidines, connected via a methylene bridge with the halogen substituted derivatives of the ophylline, 3-methylxanthine and imidazole. It was also observed that these compounds would react with N‑nucleophiles with the formation of various branched and cyclic products. The aim of this work was to determine the optimal conditions for obtaining heterocyclic products as a result of conjugation of bromomethyldihydropyrimidine and hypoxanthine at the positions C6 and C1 via a methylene bridge. It is important to note, that the latter can be widely modified by using structurally diverse aromatic aldehydes during the synthesis of dihydropyrimidine core by using Biginelli reaction, which explains structural diversity of the reaction products. After having tried various reaction conditions, we have concluded that the optimal method for obtaining the products entailed keeping equimolar ratios of bromomethyl substituted dihydropyrimidines and 1-potassium‑2-chloro‑7-methylhypoxanthine in dry ethanol for 4 hours. The ester group at the C5 of dihydropyrimidine ring and a chlorine leaving group at C2 of hypoxanthine fragments of the molecule allow to consider these structures as pro missing synthons for farther synthesis of condensed pyrimidine and xanthine systems. The structures of novel compounds have been confirmed with the methods such as HPLC/MS, 1H, and 13C NMR spectroscopy.

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5

Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "ChemInform Abstract: Synthesis of 4-Unsubstituted Dihydropyrimidines. Nucleophilic Substitution at Position-2 of Dihydropyrimidines." ChemInform 42, no. 33 (2011): no. http://dx.doi.org/10.1002/chin.201133157.

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6

Lin, Yun, Jin-Tao Liu, and Xian-Jin Yang. "One-pot Synthesis of 4-Trifluoromethyl-1,2-dihydropyrimidines." Chinese Journal of Chemistry 25, no. 1 (2007): 113–15. http://dx.doi.org/10.1002/cjoc.200790003.

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7

Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "ChemInform Abstract: Synthesis of 4-Oxopyrimidinium and 4-Oxo-1,4-dihydropyrimidines." ChemInform 30, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199932155.

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8

Khan, M. Wahab, and Nitya G. Kundu. "An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines." Journal of Chemical Research 23, no. 1 (1999): 20–21. http://dx.doi.org/10.1177/174751989902300116.

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A facile synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines is described where the Friedel–Crafts reaction on 2,6-dichloropyrimidine-4-carbonyl chloride plays a crucial role.

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9

Mehrabi, Hossein, Tayebeh Yarahmadi, and Farzaneh Alizadeh Bami. "Synthesis of 4-aryl-2-Thioxo-3,4-Dihydropyrimidines Using a Three-Component Reaction of Meldrum's Acid with Arylaldehydes and Acetylthiourea." Journal of Chemical Research 42, no. 6 (2018): 326–28. http://dx.doi.org/10.3184/174751918x15293155829494.

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A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.

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10

Yavari, Issa, Asiyeh Amirahmadi, and Mohammad Halvagar. "A Synthesis of Functionalized Thiazoles and Pyrimidine-4(3H)-thiones from 1,1,3,3-Tetramethylguanidine, Acetylenic Esters, and Aryl Isothiocyanates." Synlett 28, no. 19 (2017): 2629–32. http://dx.doi.org/10.1055/s-0036-1590862.

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Aryl isothiocyanates react with dialkyl 2-{[bis(dimethylamino)methylene]amino}maleates, generated from 1,1,3,3-tetramethylguanidine and acetylenic esters, to afford 2-(dimethylamino)-1,3-thiazole derivatives, functionalized 2-(dimethylamino)-6-thioxo-1,6-dihydropyrimidines, and ethyl 2-(dimethylamino)-6-[(4-nitrophenyl)imino]-4-phenyl-6H-1,3-thiazine-5-carboxylate, in moderate to good yields.

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