Relevant bibliographies by topics / 4-dihydropyrimidines

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '4-dihydropyrimidines'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "4-dihydropyrimidines"

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C. Heda, L. C., Rashmi Sharma, C. Pareek, and P. B. Chaudhari. "Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines." E-Journal of Chemistry 6, no. 3 (2009): 770–74. http://dx.doi.org/10.1155/2009/893812.

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P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These resu
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Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines." Tetrahedron 67, no. 14 (2011): 2661–69. http://dx.doi.org/10.1016/j.tet.2011.01.092.

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Povstyanoy, V. M., T. A. Yuyrova, A. N. Retchitskiy, and A. A. Krysko. "ALTERNATIVE METHODS OF SYNTHESIS OF NOVEL HETEROSYNTHONES – FUNCTIONALIZED HYPOXANTHINE PYRIMIDINES." Odesa National University Herald. Chemistry 26, no. 2(78) (2021): 32–39. http://dx.doi.org/10.18524/2304-0947.2021.2(78).233823.

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It has been known that derivatives of dihydropyrimidine and xanthine possess the physiological activity of the wide spectrum of action. The combination of the specified heterocyclic fragments within one molecule can lead to the increase of its known types of biological activity as well as to the discovery of novel types of activity. We have previously reported the synthesis of intermediates, which consist of functionalized dihydropyrimidines, connected via a methylene bridge with the halogen substituted derivatives of the ophylline, 3-methylxanthine and imidazole. It was also observed that the
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Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "Synthesis of 4-oxopyrimidinium and 4-oxo-1,4-dihydropyrimidines." Journal of Heterocyclic Chemistry 36, no. 1 (1999): 97–104. http://dx.doi.org/10.1002/jhet.5570360115.

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Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "ChemInform Abstract: Synthesis of 4-Unsubstituted Dihydropyrimidines. Nucleophilic Substitution at Position-2 of Dihydropyrimidines." ChemInform 42, no. 33 (2011): no. http://dx.doi.org/10.1002/chin.201133157.

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Lin, Yun, Jin-Tao Liu, and Xian-Jin Yang. "One-pot Synthesis of 4-Trifluoromethyl-1,2-dihydropyrimidines." Chinese Journal of Chemistry 25, no. 1 (2007): 113–15. http://dx.doi.org/10.1002/cjoc.200790003.

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Khan, M. Wahab, and Nitya G. Kundu. "An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines." Journal of Chemical Research 23, no. 1 (1999): 20–21. http://dx.doi.org/10.1177/174751989902300116.

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A facile synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines is described where the Friedel–Crafts reaction on 2,6-dichloropyrimidine-4-carbonyl chloride plays a crucial role.
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Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "ChemInform Abstract: Synthesis of 4-Oxopyrimidinium and 4-Oxo-1,4-dihydropyrimidines." ChemInform 30, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199932155.

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Yavari, Issa, Asiyeh Amirahmadi, and Mohammad Halvagar. "A Synthesis of Functionalized Thiazoles and Pyrimidine-4(3H)-thiones from 1,1,3,3-Tetramethylguanidine, Acetylenic Esters, and Aryl Isothiocyanates." Synlett 28, no. 19 (2017): 2629–32. http://dx.doi.org/10.1055/s-0036-1590862.

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Aryl isothiocyanates react with dialkyl 2-{[bis(dimethylamino)methylene]amino}maleates, generated from 1,1,3,3-tetramethylguanidine and acetylenic esters, to afford 2-(dimethylamino)-1,3-thiazole derivatives, functionalized 2-(dimethylamino)-6-thioxo-1,6-dihydropyrimidines, and ethyl 2-(dimethylamino)-6-[(4-nitrophenyl)im­ino]-4-phenyl-6H-1,3-thiazine-5-carboxylate, in moderate to good yields.
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Mehrabi, Hossein, Tayebeh Yarahmadi, and Farzaneh Alizadeh Bami. "Synthesis of 4-aryl-2-Thioxo-3,4-Dihydropyrimidines Using a Three-Component Reaction of Meldrum's Acid with Arylaldehydes and Acetylthiourea." Journal of Chemical Research 42, no. 6 (2018): 326–28. http://dx.doi.org/10.3184/174751918x15293155829494.

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A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.
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Dissertations / Theses on the topic "4-dihydropyrimidines"

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Sullivan, Shannon M. "Synthesis of 2,4-disubstituted pyrimidine derivatives as potential 5-HT7 receptor antagonist." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05052008-153400/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Gabor Patonay, Doyle Barrow , committee members. Electronic text (68 p. : ill.) : digital, PDF file. Description based on contents viewed June 23, 2008. Includes bibliographical references (p. 42-430.
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Govender, Reshme. "Pharmacological Screening of Substituted 1, 4 Dihydropyrimidines." Thesis, 2016. http://hdl.handle.net/10321/1712.

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Submitted in partial fulfillment for the Degree of Master of Applied Sciences in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.<br>Pharmacological research is essential for the advancement of treatment therapies to combat diseases that plague mankind. Pyrimidines have been a subject under investigation by medicinal chemists for many years due to their interesting pharmacological properties. In previous studies, pyrimidines and their derivatives have been reported to have antimicrobial, anti-inflammatory, antimalarial, analgesic, and antitumour activities amongst o
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Book chapters on the topic "4-dihydropyrimidines"

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Curtis, A. D. M. "From 4-Imino-3,4-dihydropyrimidines." In Five-Membered Hetarenes with Three or More Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-013-00895.

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Kikelj, D. "From 4-Methyl-6-thioxo-1,6-dihydropyrimidine-5-carbonitriles and 2-Ylidenemalononitriles." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00851.

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Solanki, Manish J., and V. H. Shah. "Synthesis, Characterization of Some Novel Derivatives of Thiazolo[2,3-b]dihydropyrimidine Possessing 4-Pyrazolyl Moiety and Evaluation of Their Biological Activities." In Novel Aspects on Chemistry and Biochemistry Vol. 9. B P International, 2024. http://dx.doi.org/10.9734/bpi/nacb/v9/2823g.

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Conference papers on the topic "4-dihydropyrimidines"

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Gama, Fernando H. de Souza, and Simon J. Garden. "The use of 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD) in multicomponent reactions. Synthesis of acetoacetanilides, pyridones and dihydropyrimidines." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0273-1.

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Duburs, Gunars, Brigita Vigante, Egils Bisenieks, et al. "Pleiotropic focused anticancer approach by dihydropyridines, dihydropyrimidines and heteroaromatic compounds." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05778.

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Соломийчук, М., О. Панимарчук, В. Кушнир та М. Никорюк. "Сочетание биологического препарата на основе бактерий Pseudomonas Fluorescens и стимулирующих веществ". У International Scientific Symposium "Plant Protection – Achievements and Prospects". Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2020. http://dx.doi.org/10.53040/9789975347204.34.

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Derivatives of ammonium salts of dihydropyrimidine did not show a toxic effect on reducing the concentration of viable cells of the bacterium strain AR-33 Pseudomonas fluorescens. The best indicators of the weight of 100 seeds and the number of formed beans in soybeans were shown by the combination Planriz - 5 l / ha + 0.1% solution of xymedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The use of all combinations of biocomplexes showed the effectiveness of drugs against diseases in the range of 59.31-69.63%. As a result of the use of biocomplexes, their fungicidal, immunop
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Perera, Nirmalee, Manura Weerasinghe, Jagath Kasturiarachchi, and Priyanga Ranasinghe. "In Silico Analysis of the Diversity of DPYD Gene Variants Affecting Fluoropyrimidine Toxicity: A Comparison of South Asians with Other World Populations." In SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES. Faculty of Humanities & Sciences, SLIIT, 2024. https://doi.org/10.54389/ehcv8962.

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Fluoropyrimidine (FP) chemotherapy drug is utilized to treat colon, head, neck and breast cancers. Apart from its effectiveness, toxicity is a limitation. DPD (dihydropyrimidine dehydrogenase) enzyme, which aids in the FP metabolism is produced by the highly polymorphic DPYD gene. Mutations in the DPYD gene cause the deficiency or non-functionality of the DPD enzyme which varies among different populations. This research aimed to compare allele frequencies of common DPYD gene variants of South Asians (SAS) such as DPYD*2A(rs3918290), DPYD*9(rs1801265), DPYD*5, rs2297595, DPYD*6, rs17376848, rs
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Journal articles
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