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Journal articles on the topic '4-dihydropyrimidines'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

C. Heda, L. C., Rashmi Sharma, C. Pareek, and P. B. Chaudhari. "Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines." E-Journal of Chemistry 6, no. 3 (2009): 770–74. http://dx.doi.org/10.1155/2009/893812.

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P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These resu

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2

Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines." Tetrahedron 67, no. 14 (2011): 2661–69. http://dx.doi.org/10.1016/j.tet.2011.01.092.

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3

Povstyanoy, V. M., T. A. Yuyrova, A. N. Retchitskiy, and A. A. Krysko. "ALTERNATIVE METHODS OF SYNTHESIS OF NOVEL HETEROSYNTHONES – FUNCTIONALIZED HYPOXANTHINE PYRIMIDINES." Odesa National University Herald. Chemistry 26, no. 2(78) (2021): 32–39. http://dx.doi.org/10.18524/2304-0947.2021.2(78).233823.

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It has been known that derivatives of dihydropyrimidine and xanthine possess the physiological activity of the wide spectrum of action. The combination of the specified heterocyclic fragments within one molecule can lead to the increase of its known types of biological activity as well as to the discovery of novel types of activity. We have previously reported the synthesis of intermediates, which consist of functionalized dihydropyrimidines, connected via a methylene bridge with the halogen substituted derivatives of the ophylline, 3-methylxanthine and imidazole. It was also observed that the

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4

Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "Synthesis of 4-oxopyrimidinium and 4-oxo-1,4-dihydropyrimidines." Journal of Heterocyclic Chemistry 36, no. 1 (1999): 97–104. http://dx.doi.org/10.1002/jhet.5570360115.

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5

Cho, Hidetsura, Yoshio Nishimura, Yoshizumi Yasui, et al. "ChemInform Abstract: Synthesis of 4-Unsubstituted Dihydropyrimidines. Nucleophilic Substitution at Position-2 of Dihydropyrimidines." ChemInform 42, no. 33 (2011): no. http://dx.doi.org/10.1002/chin.201133157.

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6

Lin, Yun, Jin-Tao Liu, and Xian-Jin Yang. "One-pot Synthesis of 4-Trifluoromethyl-1,2-dihydropyrimidines." Chinese Journal of Chemistry 25, no. 1 (2007): 113–15. http://dx.doi.org/10.1002/cjoc.200790003.

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7

Khan, M. Wahab, and Nitya G. Kundu. "An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines." Journal of Chemical Research 23, no. 1 (1999): 20–21. http://dx.doi.org/10.1177/174751989902300116.

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A facile synthesis of 4-acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-acyl-6-aryl-2-oxo-2,3-dihydropyrimidines is described where the Friedel–Crafts reaction on 2,6-dichloropyrimidine-4-carbonyl chloride plays a crucial role.

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8

Vedernikova, Irina V., Achiel Haemers, and Yuryi I. Ryabukhin. "ChemInform Abstract: Synthesis of 4-Oxopyrimidinium and 4-Oxo-1,4-dihydropyrimidines." ChemInform 30, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199932155.

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9

Yavari, Issa, Asiyeh Amirahmadi, and Mohammad Halvagar. "A Synthesis of Functionalized Thiazoles and Pyrimidine-4(3H)-thiones from 1,1,3,3-Tetramethylguanidine, Acetylenic Esters, and Aryl Isothiocyanates." Synlett 28, no. 19 (2017): 2629–32. http://dx.doi.org/10.1055/s-0036-1590862.

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Aryl isothiocyanates react with dialkyl 2-{[bis(dimethylamino)methylene]amino}maleates, generated from 1,1,3,3-tetramethylguanidine and acetylenic esters, to afford 2-(dimethylamino)-1,3-thiazole derivatives, functionalized 2-(dimethylamino)-6-thioxo-1,6-dihydropyrimidines, and ethyl 2-(dimethylamino)-6-[(4-nitrophenyl)imino]-4-phenyl-6H-1,3-thiazine-5-carboxylate, in moderate to good yields.

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10

Mehrabi, Hossein, Tayebeh Yarahmadi, and Farzaneh Alizadeh Bami. "Synthesis of 4-aryl-2-Thioxo-3,4-Dihydropyrimidines Using a Three-Component Reaction of Meldrum's Acid with Arylaldehydes and Acetylthiourea." Journal of Chemical Research 42, no. 6 (2018): 326–28. http://dx.doi.org/10.3184/174751918x15293155829494.

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A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.

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11

Kumar, R., V. K. Sehgal, B. Kaur, and R. Kaur. "Cardiodepressant Activity of Newer Dihydropyrimidine Derivative in Comparison to Nifedipine on Perfused Rabbits Heart." International Journal of Medical and Dental Sciences 1, no. 2 (2012): 6. http://dx.doi.org/10.18311/ijmds/2012/18695.

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<p><strong>Background</strong>: Substituted dihydropyridine calcium channel blockers are used in the treatment of cardiovascular diseases. Dihydropyridines are considered as analogue of dihydropyrimidines.</p><p><strong>Objectives</strong>: In present study newly synthesized test compound 5- Acyl-6-methyl-4(2',3'-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4- dihydropyrimidine, a dihydropyrimidine derivative was investigated with an aim to get valuable substitute for the well known dihydropyridine, Nifedipine.</p><p><strong>Material &

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12

Kadysh, V., J. Stradins, H. Khanina, and G. Duburs. "Electrochemical oxidation of 4-aryl-1,4-dihydropyrimidines on a carbon electrode." Electrochimica Acta 34, no. 7 (1989): 899–904. http://dx.doi.org/10.1016/0013-4686(89)80014-3.

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13

Sarode, Varsha I., and Ritesh P. Bhole. "Synthesis, Characterization of 2-Methylthio-1, 4-dihydropyrimidines for its Antibacterial potential." Research Journal of Pharmacy and Technology 12, no. 4 (2019): 1585. http://dx.doi.org/10.5958/0974-360x.2019.00263.4.

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14

Guo, Yongbiao, Chuanpin Zou, Zhenhua Gao, et al. "Highly Enantioselective Biginelli Reaction of Aliphatic Aldehydes Catalyzed by Chiral Phosphoric Acids." Synlett 28, no. 15 (2017): 2041–45. http://dx.doi.org/10.1055/s-0036-1588853.

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Several chiral phosphoric acids were evaluated as organocatalysts for the enantioselective Biginelli reaction of aliphatic aldehydes. With a chiral phosphoric acid derived from 3,3′-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1,1′-binaphthalene-2,2′-diol, and after extensive optimization of the reaction conditions, the corresponding dihydropyrimidines were obtained in moderate to high yields with 73–87% ee by a three-component reaction of an aliphatic aldehyde, urea, and a β-keto ester.

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15

Kim, Yong Hae, and Byoung Uk Lim. "A novel tautomerism in alkyl dihydropyrimidines : observation of tautomerism by H-D exchange of 2- and/or 4-methyl protons of dihydropyrimidines in CD3OD." Tetrahedron Letters 32, no. 18 (1991): 2057–60. http://dx.doi.org/10.1016/s0040-4039(00)78907-6.

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16

Nivedita, Srivastava, Mehrotra Arti, and Kumar Anil. "Synthesis of dihydropyrimidinones derivatives by Biginelli reaction in basic medium." Journal of Indian Chemical Society Vol. 92, Oct 2015 (2015): 1553–56. https://doi.org/10.5281/zenodo.5700985.

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Bioorganic & Heterocyclic Research Laboratory, Department of Applied Chemistry, Faculty of Engineering & Technology, M. J. P. Rohilkhand University, Bareilly-243 006, Uttar Pradesh, India <em>E-mail </em>: drnimjpru@rediffmail.com, niveditacdri2000@yahoo.com <em>Manuscript received online 12 December 2014, accepted 04 March 2015</em> A simple, clean and convenient one-pot method has been developed for the synthesis of 4-substituted-3,4- dihydropyrimidinone by multicomponent condensation of ethyl acetoacetate, aromatic aldehydes and urea in basic medium in the presence of ethanol under

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17

Zhdanov, Yu A., I. V. Vedernikova, Yu N. Simkina, et al. "Synthesis and psychotropic activity of 4-oxo-1-[hydroxy(acetoxy)phenyl]-1,4-dihydropyrimidines." Pharmaceutical Chemistry Journal 23, no. 5 (1989): 378–83. http://dx.doi.org/10.1007/bf00758288.

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18

van der Stoel, R. E., H. C. van der Plas, and H. Jongejan. "Photochemical ring contraction of 4-heteroaryl-substituted 1,4(or 3,4)-dihydropyrimidines into imidazoles." Recueil des Travaux Chimiques des Pays-Bas 102, no. 7-8 (2010): 364–67. http://dx.doi.org/10.1002/recl.19831020706.

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19

Védernikova, I. V., Yu I. Ryabukhin, M. I. Haitin, and Yu N. Simkina. "Synthèse et Identification des 4-OXO-1,4-Dihydropyrimidines en vue des Applications Pharmacologiques." Bulletin des Sociétés Chimiques Belges 100, no. 6 (2010): 487–92. http://dx.doi.org/10.1002/bscb.19911000608.

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20

Mahran, Asma Mohamed, Nasser Abdelhamid Hassan, Dalia Ahmed A. Osman, Sherif Shaban Ragab, and Allam Abdelhamid Hassan. "Synthesis and biological evaluation of novel pyrimidines derived from 6-aryl-5-cyano-2-thiouracil." Zeitschrift für Naturforschung C 71, no. 5-6 (2016): 133–40. http://dx.doi.org/10.1515/znc-2015-0265.

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Abstract Starting from 6-aryl-5-cyano-2-thiouracil derivative 1a–f, a series of novel thiazolo[3,2-a]pyrimidines 4a–f were synthesized. The mechanism and the regioselectivity of the studied reactions are discussed. In addition, a series of tetrahydro-4-H-pyrimido[2,1-b][1,3]thiazines 7a–e and 2-((ethoxymethyl)thio)-4-aryl-1,6-dihydropyrimidines 9b,c,e were synthesized. The anti-microbial activities of some of the prepared compounds were screened, and the results revealed that compounds 3c and 4c were more active than the standard (Ampicillin) against gram positive bacteria (Pseudomonas aerugin

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21

Ajumeera, Rajanna, Ganapathi Thipparapu, Shireesha Boyapati, Bharath Singh Padya, and Vijayalaxmi Venkatesan. "Synthesis and Evaluation of Triazolyl Dihydropyrimidines as Potential Anticancer Agents." International Journal of Chemistry 10, no. 4 (2018): 18. http://dx.doi.org/10.5539/ijc.v10n4p18.

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Novel N &ndash; triazolyl 3(a-f) and O-triazolyl (4a-f) derivatives of 4, 6-diaryl-1, 4-dihydropyrimidines were synthesized through mannich reaction. All compounds were characterized by physical and spectral data. These compounds were screened for in vitro efficiency in human breast cancer cell (MCF-7&amp;MDA-MB-231) lines and found to have very good anti-proliferative activity.&nbsp; Among all compounds of 4b, 3e, 4e endowed with lesser respective IC50 values of 31.94, 55.73, 55.03 &micro;M in MCF-7 cells and 41.50, 35.28, 32.06 &micro;M in MDA-MB 231 cells by MTT assay. I

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22

Memarian, H. R., and S. Amini. "Computational Studies on the Rotamers of 4-Aryl-2-Oxo-1,2,3,4-Tetrahydropyrimidines and 4-Aryl-2-Oxo-1,2-Dihydropyrimidines." Journal of Structural Chemistry 60, no. 3 (2019): 377–93. http://dx.doi.org/10.1134/s0022476619030053.

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23

Karade, Nandkishor N., Sumit V. Gampawar, Nilesh P. Tale, and Sanjay B. Kedar. "ChemInform Abstract: Mild and Efficient Oxidative Aromatization of 4-Substituted-1,4-dihydropyrimidines Using (Diacetoxyiodo)benzene." ChemInform 41, no. 44 (2010): no. http://dx.doi.org/10.1002/chin.201044164.

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24

Lorente, A., J. L. García Navío, J. J. Vaquero, and J. L. Soto. "Synthesis of heterocyclic compounds. XXXIX. Synthesis of 5-cyano-2-phenyl-4-thioxo-3,4-dihydropyrimidines." Journal of Heterocyclic Chemistry 22, no. 1 (1985): 49–51. http://dx.doi.org/10.1002/jhet.5570220113.

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25

Remennikov, G. Ya, I. V. Boldyrev, S. A. Kravchenko, and V. V. Pirozhenko. "Synthesis and some conversions of 4-aryl-6-methyl-2-methoxy(phenyl)-5-nitro-1,4-dihydropyrimidines." Chemistry of Heterocyclic Compounds 29, no. 10 (1993): 1200–1205. http://dx.doi.org/10.1007/bf00538068.

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26

Ivanov, A. S., N. Z. Tugusheva, L. M. Alekseeva, and V. G. Granik. "Synthesis and hydrolytic cleavage of 1-aryl-5-cyano-6-(2-dimethylaminovinyl)-4-oxo(thioxo)-1,4-dihydropyrimidines." Russian Chemical Bulletin 53, no. 4 (2004): 873–81. http://dx.doi.org/10.1023/b:rucb.0000037857.07190.75.

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27

Ahmad, Muhammad Jawad, Syed Fahad Hassan, Riffat Un Nisa, et al. "Synthesis, in vitro potential and computational studies on 2-amino-1, 4-dihydropyrimidines as multitarget antibacterial ligands." Medicinal Chemistry Research 25, no. 9 (2016): 1877–94. http://dx.doi.org/10.1007/s00044-016-1613-z.

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28

Zhu, Jie, Mingjie Zhang, Bo Liu, and Xiaojuan Li. "New Ytterbium Complex-catalyzed Multicomponent Reactions for Synthesis of Dihydropyrimidines: [4+2] Cycloaddition vs. Biginelli Type Reaction." Chemistry Letters 38, no. 1 (2009): 56–57. http://dx.doi.org/10.1246/cl.2009.56.

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29

Khan, M. Wahab, and Nitya G. Kundu. "An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines." Journal of Chemical Research, no. 1 (1999): 20–21. http://dx.doi.org/10.1039/a806787b.

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30

Dobosz, Robert, and Ryszard Gawinecki. "Quantum chemical prediction of structure and stability of the benzodihydropyrimidine tautomers." Journal of Theoretical and Computational Chemistry 13, no. 07 (2014): 1450056. http://dx.doi.org/10.1142/s0219633614500564.

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B3LYP/maug-cc-pVTZ and MP2/maug-cc-pVTZ calculations show that 3,4-dihydro-quinazoline and its 2- and/or 4-methyl and -phenyl substituted derivatives in solution (chloroform, DMSO, methanol) are only by 0.3 kcal/mol–2.2 kcal/mol more stable than the respective tautomeric 1,4-dihydroquinazolines (the available literature experimental stability data are not coherent). In the gas phase, 2- and/or 4-substituted tautomers of 3,4-dihydroquinazoline are also energetically preferred (B3LYP/maug-cc-pVTZ, MP2/maug-cc-pVTZ and CCSD/cc-pVDZ calculations lead to the same conclusion). In vacuum, 1,4-dihydro

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31

Lorente, Antonio, José L. Garcia Navio, Luis Fuentes, and José L. Soto. "Synthesis of 6-Aryl-5-isopropoxycarbonyl-4-thioxo-3,4-dihydropyrimidines from 3-Substituted Alkyl 2-Cyano-3-thiocarboxamidopropenoates." Synthesis 1985, no. 01 (1985): 86–89. http://dx.doi.org/10.1055/s-1985-31120.

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32

Elumalai, Karthikeyan, Mohammed Ashraf Ali, Manogaran Elumalai, Kalpana Eluri, and Sivaneswari Srinivasan. "Design, synthesis and antimycobacterial activity of some novel 3,5-dichloro-2-ethoxy-6-fluoropyridin-4 amine cyclocondensed dihydropyrimidines." Journal of Pharmacy Research 7, no. 3 (2013): 241–45. http://dx.doi.org/10.1016/j.jopr.2013.03.016.

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33

Khan, M. Wahab, and Nitya G. Kundu. "ChemInform Abstract: An Expeditious Synthesis of 4-Acyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidines (6-Acyl uracils) and 4-Acyl-6-aryl-2-oxo-2,3-dihydropyrimidines." ChemInform 30, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199925146.

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34

E. Ali, Tarik, Mohammed A. Assiri, Mamdouh M. Ali, Abeer E. M. Ali, Ibrahim S. Yahia, and Heba Y. Zahran. "Efficient Synthesis and Anticancer Activities of Some Novel Functionalized (4-Oxo-4H-chromen-3-yl)-2-selenoxo-1,2-dihydropyrimidines." HETEROCYCLES 100, no. 11 (2020): 1831. http://dx.doi.org/10.3987/com-20-14324.

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35

Yu, Han, Peng Xu, Huihong He, Jun Zhu, Hualin Lin, and Sheng Han. "Highly enantioselective Biginelli reactions using methanopyroline/thiourea – based dual organocatalyst systems: asymmetric synthesis of 4-substituted unsaturated aryl dihydropyrimidines." Tetrahedron: Asymmetry 28, no. 2 (2017): 257–65. http://dx.doi.org/10.1016/j.tetasy.2016.11.015.

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36

Kappe, C. Oliver. "Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage." Bioorganic & Medicinal Chemistry Letters 10, no. 1 (2000): 49–51. http://dx.doi.org/10.1016/s0960-894x(99)00572-7.

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37

MA, Zhengyue, Guoying YAN, Shiguo ZHU, Gengliang YANG, and Duqiang LUO. "Cyclocondensation Reations of 3-Amino-1,2,4-triazole with 3-(Benzylidene)-6-fluoro-thiochroman-4-ones to Tetracyclically Fused Dihydropyrimidines and Pyrimidines." Chinese Journal of Chemistry 27, no. 5 (2009): 987–92. http://dx.doi.org/10.1002/cjoc.200990168.

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38

Tong, Shuo, Qian Wang, Mei-Xiang Wang, and Jieping Zhu. "Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence." Chemistry - A European Journal 22, no. 24 (2016): 8332–38. http://dx.doi.org/10.1002/chem.201601560.

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39

Nishimura, Yoshio, and Hidetsura Cho. "Synthesis of 4-unsubstituted dihydropyrimidines having acyl and alkoxycarbonyl groups at 5- and 6-positions by cyclization–elimination reactions using 1,3-diaza-1,3-butadienes." Tetrahedron Letters 55, no. 2 (2014): 411–14. http://dx.doi.org/10.1016/j.tetlet.2013.11.038.

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40

Nishimura, Yoshio, and Hidetsura Cho. "ChemInform Abstract: Synthesis of 4-Unsubstituted Dihydropyrimidines Having Acyl and Alkoxycarbonyl Groups at 5- and 6-Positions by Cyclization-Elimination Reactions Using 1,3-Diaza-1,3-butadienes." ChemInform 45, no. 25 (2014): no. http://dx.doi.org/10.1002/chin.201425177.

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41

Al-Wahaibi, Lamya H., Althaf Shaik, Mohammed A. Elmorsy, et al. "Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors." Molecules 26, no. 11 (2021): 3286. http://dx.doi.org/10.3390/molecules26113286.

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In this report, we describe the structural characterization of three 2,4-disubstituted-dihydropyrimidine-5-carbonitrile derivatives, namely 2-{[(4-nitrophenyl)methyl]sulfanyl}-6-oxo-4-propyl-1,6-dihydropyrimidine-5-carbonitrile 1, 4-(2-methylpropyl)-2-{[(4-nitrophenyl)methyl]sulfanyl}-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2, and 2-[(2-ethoxyethyl)sulfanyl]-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile monohydrate 3. An X-ray diffraction analysis revealed that these compounds were crystallized in the centrosymmetric space groups and adopt an L-shaped conformation. One of the compound

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42

Fathima, Nikhath, H. Nagarajaiah, and Noor Shahina Begum. "Methyl 4-(4-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate." Acta Crystallographica Section E Structure Reports Online 70, no. 3 (2014): o306. http://dx.doi.org/10.1107/s1600536814002888.

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In the title molecule, C13H14N2O3S, the dihydropyrimidine ring is in a flattened sofa conformation, with the methine C atom forming the flap. The dihedral angle between the mean plane of the five essentially planar atoms of the dihydropyrimidine ring [maximum deviation = 0.056 (4) Å] and the benzene ring is 89.4 (2)°. The O atom of the carbonyl group is in atransconformation with respect to the C=C bond of the dihydropyrimidine ring. In the crystal, N—H...O and O—H...S hydrogen bonds connect molecules, forming a two-dimensional network parallel to (001).

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43

Thanki, Pragna H., Dhaval V. Hingrajiya, Jayesh J. Modha, and Jalpa H. Vadgama. "Synthesis, characterization and antibiotic evaluation of various biologically active derivatives of 4-Alkylpyrimidine-5-carbonitrile." Current Chemistry Letters 12, no. 3 (2023): 537–44. http://dx.doi.org/10.5267/j.ccl.2023.3.002.

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Extensive research work has been published on Tetrahydro and Dihydropyrimidine derivatives. Pyrimidine-5-Carbonitrile and its analogs have demonstrated a large number of activities. Some 6-Halogenosubstituted pyrimidine analogs have also been reported to be biologically active to a certain extent, but the literature survey reveals not much report on 6-alkylated pyrimidine derivatives. Targeting enhancement in biologically useful properties of a lead molecule through the association of it with active pharmacophoric groups or molecules is a conventional method in pharmaceutical research. With an

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44

Begum, Noor Shahina, and D. E. Vasundhara. "Synthesis, Spectroscopic and Crystal Structure Analysis of Two Dihydropyrimidines." Journal of Chemical Research 2009, no. 4 (2009): 201–4. http://dx.doi.org/10.3184/030823409x425064.

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The preparation of two reduced pyrimidine derivatives, ethyl 3-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and ethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate, is described, along with details of their crystal structure analysis.

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45

Rovnyak, George C., Karnail S. Atwal, Anders Hedberg, et al. "Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents." Journal of Medicinal Chemistry 35, no. 17 (1992): 3254–63. http://dx.doi.org/10.1021/jm00095a023.

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Mohamed, Mosaad, Samir Awad, and Naglaa Ahmed. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica 61, no. 2 (2011): 171–85. http://dx.doi.org/10.2478/v10007-011-0019-1.

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Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivativesA series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-dto10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropy

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Patel1, Ankita S., Ujashkumar A. Shah2, Hirak V. Joshi, et al. "Design, synthesis and biological screening of novel heterocyclic ring derivatives as antibacterial agents." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4650–56. http://dx.doi.org/10.55522/jmpas.v11i2.2623.

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For a long time, numerous attempts are being made by researchers to discover and develop new antimicrobial agents based on synthetic compounds and medicinal plants. These attempts were forced due to increasing rate of microbial resistance. In the present study, it has been discussed that the synthesis of various dihydropyrimidine fused with benzimidazole moiety. In which o-phenylenediamine and chloroacetic acid react in acidic medium by nucleophilic addition reaction to form 2-chloro methyl Benzimidazole. (1). The substituted Chalcone (2) was synthesized by a claisan-schmidt condensation react

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Suwito, Hery, Noorma Kurnyawaty, Ellyca Susetyo, et al. "(E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxy-phenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one and (E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one." Molbank 2019, no. 2 (2019): M1063. http://dx.doi.org/10.3390/m1063.

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Dihydropyrimidine derivatives possess great potential to be used as a precursor for the synthesis of wide diverse dihydropyrimidine-like derivatives. In this research, the title compounds were synthesized through the reaction between 5-acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione and 2,5-dimethoxybenzladehyde under aldol condensation condition. The title compound, (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)]}prop-2-en-1-one (yield 15%), was obtained as major product, whereas (E)-3-(

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Nishimura, Yoshio, Takanori Kubo, Saho Takayama, Hanako Yoshida, and Hidetsura Cho. "Palladium-catalyzed/copper-mediated carbon–carbon cross-coupling reaction for synthesis of 6-unsubstituted 2-aryldihydropyrimidines." RSC Advances 12, no. 43 (2022): 28113–22. http://dx.doi.org/10.1039/d2ra05155a.

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This protocol enables the synthesis of 6-unsubstituted 2-aryldihydropyrimidines using various substituents at the 2- and 4-positions, which would impact dihydropyrimidine-based biological and pharmacological studies.

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Anuradha, N., A. Thiruvalluvar, K. Pandiarajan, S. Chitra, and R. J. Butcher. "5-Acetyl-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-thione." Acta Crystallographica Section E Structure Reports Online 65, no. 3 (2009): o564—o565. http://dx.doi.org/10.1107/s1600536809005029.

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