Relevant bibliographies by topics / 4-Dihydropyrimidins

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Academic literature on the topic '4-Dihydropyrimidins'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "4-Dihydropyrimidins"

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Moradi, Farzaneh, Masumeh Abdoli-Senejani, and Majid Ramezani. "Isoniazid-functionalized Fe3O4 Magnetic Nanoparticles as a Green and Efficient Catalyst for the Synthesis of 3, 4-dihydropyrimidin-2(1H)-ones and their Sulfur Derivatives." Current Organic Synthesis 17, no. 1 (2020): 46–54. http://dx.doi.org/10.2174/1570179416666191118110316.

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Background: A wide variety of dihydropyrimidins (DHPMs) exhibit pharmacological and biological activities. Herein, an efficient one-pot synthesis of some 3, 4-dihydropyrimidin-2(1H)-one derivatives is reported using Fe3O4 @SiO2–Pr-INH. Objective: Recently, several catalysts have been used to improve the Biginellis-reaction. However, some of these catalysts have imperfections. Herein, a convenient method for the synthesis of 3, 4-dihydropyrimidin- 2(1H)-ones and their sulfur derivatives using Fe3O4 @SiO2–Pr-INH is reported. Materials and Methods: Firstly, the catalyst was synthesized through a
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Kolosov, Maksim A., Olesia G. Kulyk, Muataz Al-Ogaili, and Valeriy D. Orlov. "Synthesis and Acylation of 4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)- ones." Zeitschrift für Naturforschung B 67, no. 9 (2012): 921–24. http://dx.doi.org/10.5560/znb.2012-0182.

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4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)-ones are useful multifunctional 3,4-dihydropyrimidine building blocks with low molecular weight and sufficient solubility, which may be modified selectively by substituents in different positions. Here we propose a simple one-pot protocol for the synthesis of these compounds, which is based on the use of common reagents viz. urea, chloroaliphatic aldehydes and 3-ketoesters. Acylation of 4-chloroalkyl-3,4-dihydropyrimidin-2(1H)-ones by carboxylic acid anhydrides leads to 3-acyl derivatives
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C. Heda, L. C., Rashmi Sharma, C. Pareek, and P. B. Chaudhari. "Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines." E-Journal of Chemistry 6, no. 3 (2009): 770–74. http://dx.doi.org/10.1155/2009/893812.

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P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These resu
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Wanare, Rajendra K. "Design, Synthesis and Evaluation of Novel Thiopyrimidine-Glucuronide Compounds with Promising Biological Activities." Asian Journal of Organic & Medicinal Chemistry 7, no. 3 (2022): 239–44. http://dx.doi.org/10.14233/ajomc.2022.

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3-Methyl-5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2-dihydropyrimidin-4-yl)amino]-1,2-benzisoxazoles (2a-n) were obtained from N-(5-acetyl-3-methyl-1,2-benzoxazol-7-yl)-3-arylprop-2-enamides (1a-n) and thiourea. Products (2a-n) oxidized with KMnO4 to afford 5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2- dihydropyrimidin-4-yl)amino]-1,2-benzisoxazole-3-carboxylic acids (3a-n). Reaction of 3a-n with D-gluconic acid and pyridine yielded β-D-glucuronosyl-5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2- dihydropyrimidin-4-yl)amino]-1,2-benzisoxazol-3-carboxylates (4a-n). The present synthesis featured the formation
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K. Wanare, Rajendra. "Design, Synthesis and Evaluation of Novel Thiopyrimidine-Glucuronide Compounds with Promising Biological Activities." Asian Journal of Organic & Medicinal Chemistry 7, no. 3 (2022): 239–44. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p397.

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3-Methyl-5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2-dihydropyrimidin-4-yl)amino]-1,2-benzisoxazoles (2a-n) were obtained from N-(5-acetyl-3-methyl-1,2-benzoxazol-7-yl)-3-arylprop-2-enamides (1a-n) and thiourea. Products (2a-n) oxidized with KMnO4 to afford 5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2-dihydropyrimidin-4-yl)amino]-1,2-benzisoxazole-3-carboxylic acids (3a-n). Reaction of 3a-n with D-gluconic acid and pyridine yielded β-D-glucuronosyl-5-acetyl-7-[(2-sulfanylidene-6-aryl-1,2-dihydropyrimidin-4-yl)amino]-1,2-benzisoxazol-3-carboxylates (4a-n). The present synthesis featured the formation of
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Suwito, Hery, Noorma Kurnyawaty, Ellyca Susetyo, et al. "(E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxy-phenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one and (E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one." Molbank 2019, no. 2 (2019): M1063. http://dx.doi.org/10.3390/m1063.

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Dihydropyrimidine derivatives possess great potential to be used as a precursor for the synthesis of wide diverse dihydropyrimidine-like derivatives. In this research, the title compounds were synthesized through the reaction between 5-acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione and 2,5-dimethoxybenzladehyde under aldol condensation condition. The title compound, (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)]}prop-2-en-1-one (yield 15%), was obtained as major product, whereas (E)-3-(
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Kolosov, Maksim A., Valeriy D. Orlov, Valeriy V. Vashchenko, Svetlana V. Shishkina, and Oleg V. Shishkin. "5-Cinnamoyl- and 5-(Ethoxycarbonyl)-6-styryl Derivatives of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones." Collection of Czechoslovak Chemical Communications 72, no. 9 (2007): 1219–28. http://dx.doi.org/10.1135/cccc20071219.

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Several 5-cinnamoyl- and 5-(ethoxycarbonyl)-6-styryl derivatives of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones were obtained and their physicochemical properties were investigated. The introduction of alkyl substituent in position 1 of dihydropyrimidine ring was shown to promote the Claisen-Schmidt reaction on acetyl group only; without the alkyl both acetyl and 6-methyl groups participate in the reaction.
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Harutyunyan, A. A., A. S. Sumbatyan, A. A. Hambardzumyan, et al. "Synthesis, docking and biological activity of antimetabolites based on uraciles and 5-substituted 2,6-dimethylpyrimidin-4(3<i>h</i>)-ones." Журнал органической химии 59, no. 9 (2023): 1179–92. http://dx.doi.org/10.31857/s0514749223090082.

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5-Substituted 2,4-dimethyl-1,6-dihydropyrimidin-6-ones reacted with aromatic aldehydes to form 5-substituted (Z)-2-(2-aryl)-1-ethenylpyrimidin-6-ones, and in the reaction of 5-(4-fluorobenzyl)-2,6-dimethylpyrimidin-4(3 H )-one with 4-fluorobenzaldehyde, 5-(4-fluorobenzyl)-2,6-bis[( E )-4-fluorostyryl]pyrimidin-4(3 H )-one. Uracil and 5-fluorouracil were alkylated with 4-methoxy-2-chloromethylbenzaldehyde to give 2-[2,4-dioxoand 5-fluoro-2,4-dioxo-3,4-dihydropyrimidine-1(2 H )methyl]-4-methoxybenzaldehydes and are condensed with 5-substituted 2,4-dimethyl-1,6-dihydropyrimidin-6-ones to form 1-{
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Garg, Vishal, Dinesh Jindal, and Rambir Singh. "SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF 4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES." Tropical Journal of Pharmaceutical and Life Sciences 7, no. 6 (2020): 08–12. https://doi.org/10.61280/tjpls.v7i6.45.

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In the present work was designed to synthesize and evaluate the antifungal activity of 4, 6-diphenyl-3, 4- dihydropyrimidine-2-(1H)-one derivatives. The 3, 4- dihydropyrimidin 2 (1H)-one was used as nucleus for the synthesis of N-mannich bases of pyrimidine derivatives. All synthesized intermediates and products were identified on the basis of melting point range, Rf value, Elemental analysis, and IR spectral analysis. The synthesized compounds were screened for their antifungal activity against Candida albicans (MTCC 227) and Aspergillus niger (MTCC 282) in Sabouraud’s dextrose agar medium us
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Povstyanoy, V. M., T. A. Yuyrova, A. N. Retchitskiy, and A. A. Krysko. "ALTERNATIVE METHODS OF SYNTHESIS OF NOVEL HETEROSYNTHONES – FUNCTIONALIZED HYPOXANTHINE PYRIMIDINES." Odesa National University Herald. Chemistry 26, no. 2(78) (2021): 32–39. http://dx.doi.org/10.18524/2304-0947.2021.2(78).233823.

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It has been known that derivatives of dihydropyrimidine and xanthine possess the physiological activity of the wide spectrum of action. The combination of the specified heterocyclic fragments within one molecule can lead to the increase of its known types of biological activity as well as to the discovery of novel types of activity. We have previously reported the synthesis of intermediates, which consist of functionalized dihydropyrimidines, connected via a methylene bridge with the halogen substituted derivatives of the ophylline, 3-methylxanthine and imidazole. It was also observed that the
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Dissertations / Theses on the topic "4-Dihydropyrimidins"

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Sullivan, Shannon M. "Synthesis of 2,4-disubstituted pyrimidine derivatives as potential 5-HT7 receptor antagonist." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05052008-153400/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Gabor Patonay, Doyle Barrow , committee members. Electronic text (68 p. : ill.) : digital, PDF file. Description based on contents viewed June 23, 2008. Includes bibliographical references (p. 42-430.
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Govender, Reshme. "Pharmacological Screening of Substituted 1, 4 Dihydropyrimidines." Thesis, 2016. http://hdl.handle.net/10321/1712.

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Submitted in partial fulfillment for the Degree of Master of Applied Sciences in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.<br>Pharmacological research is essential for the advancement of treatment therapies to combat diseases that plague mankind. Pyrimidines have been a subject under investigation by medicinal chemists for many years due to their interesting pharmacological properties. In previous studies, pyrimidines and their derivatives have been reported to have antimicrobial, anti-inflammatory, antimalarial, analgesic, and antitumour activities amongst o
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Book chapters on the topic "4-Dihydropyrimidins"

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Weitzdoerfer, R., M. Fountoulakis, and G. Lubec. "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain." In Protein Expression in Down Syndrome Brain. Springer Vienna, 2001. http://dx.doi.org/10.1007/978-3-7091-6262-0_8.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of iron(II) complex with N-(6-amino-3-methyl-5-nitroso-4-oxo-3,4-dihydropyrimidin-2yl)glycine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_223.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) complex with N-(6-amino-3-methyl-5-nitroso-4-oxo-3,4-dihydropyrimidin-2yl)glycine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_501.

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Curtis, A. D. M. "From 4-Imino-3,4-dihydropyrimidines." In Five-Membered Hetarenes with Three or More Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-013-00895.

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Kikelj, D. "From 4-Methyl-6-thioxo-1,6-dihydropyrimidine-5-carbonitriles and 2-Ylidenemalononitriles." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00851.

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Solanki, Manish J., and V. H. Shah. "Synthesis, Characterization of Some Novel Derivatives of Thiazolo[2,3-b]dihydropyrimidine Possessing 4-Pyrazolyl Moiety and Evaluation of Their Biological Activities." In Novel Aspects on Chemistry and Biochemistry Vol. 9. B P International, 2024. http://dx.doi.org/10.9734/bpi/nacb/v9/2823g.

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Conference papers on the topic "4-Dihydropyrimidins"

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Chinmayi, N., Y. C. Sunil Kumar, and Manikanta Murahari. "Synthesis of 3, 4-dihydropyrimidin-2(1H)-one derivatives and evaluation of their antibacterial activity." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS RESEARCH (ICAMR - 2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0022452.

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Gama, Fernando H. de Souza, and Simon J. Garden. "The use of 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD) in multicomponent reactions. Synthesis of acetoacetanilides, pyridones and dihydropyrimidines." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0273-1.

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Соломийчук, М., О. Панимарчук, В. Кушнир та М. Никорюк. "Сочетание биологического препарата на основе бактерий Pseudomonas Fluorescens и стимулирующих веществ". У International Scientific Symposium "Plant Protection – Achievements and Prospects". Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2020. http://dx.doi.org/10.53040/9789975347204.34.

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Derivatives of ammonium salts of dihydropyrimidine did not show a toxic effect on reducing the concentration of viable cells of the bacterium strain AR-33 Pseudomonas fluorescens. The best indicators of the weight of 100 seeds and the number of formed beans in soybeans were shown by the combination Planriz - 5 l / ha + 0.1% solution of xymedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The use of all combinations of biocomplexes showed the effectiveness of drugs against diseases in the range of 59.31-69.63%. As a result of the use of biocomplexes, their fungicidal, immunop
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Sachdeva, Nikhil, Anton Dolzhenko, and Wai Chui. "Reaction of N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)guanidine with benzaldehyde: experimental and theoretical investigation of the product." In The 12th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2008. http://dx.doi.org/10.3390/ecsoc-12-01224.

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Naikoo, Rawoof Ahmad, Muzzaffar Ahmad Mir, Sami Ullah Bhat, Radha Tomar, and S. S. Tomar. "Nanoporous Zeolite H-A material: An efficient, reusable and benign catalyst for the synthesis of 3, 4-Dihydropyrimidin-2(1H )-ones under solvent free conditions." In Proceedings of the International Conference on Nanotechnology for Better Living. Research Publishing Services, 2016. http://dx.doi.org/10.3850/978-981-09-7519-7nbl16-rps-193.

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Perera, Nirmalee, Manura Weerasinghe, Jagath Kasturiarachchi, and Priyanga Ranasinghe. "In Silico Analysis of the Diversity of DPYD Gene Variants Affecting Fluoropyrimidine Toxicity: A Comparison of South Asians with Other World Populations." In SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES. Faculty of Humanities & Sciences, SLIIT, 2024. https://doi.org/10.54389/ehcv8962.

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Fluoropyrimidine (FP) chemotherapy drug is utilized to treat colon, head, neck and breast cancers. Apart from its effectiveness, toxicity is a limitation. DPD (dihydropyrimidine dehydrogenase) enzyme, which aids in the FP metabolism is produced by the highly polymorphic DPYD gene. Mutations in the DPYD gene cause the deficiency or non-functionality of the DPD enzyme which varies among different populations. This research aimed to compare allele frequencies of common DPYD gene variants of South Asians (SAS) such as DPYD*2A(rs3918290), DPYD*9(rs1801265), DPYD*5, rs2297595, DPYD*6, rs17376848, rs
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