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Journal articles on the topic '4-methoxycinnamic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Tasha, Rossa Auli, Juni Ekowati, Suzana, and Saipul Maulana. "Docking study and molecular dynamic approach to predicting the activity of 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid against COX-1 enzyme." Pharmacy Education 23, no. 4 (2023): 173–79. http://dx.doi.org/10.46542/pe.2023.234.173179.

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Background: Ferulic acid is a phenolic acid compound that has anti-inflammatory and anti-thrombosis activity. However, ferulic acid has the disadvantage of poor absorption. Structural modifications can be made to increase the biological activity of the compound. In this research, the structure of ferulic acid was modified into 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid. Objective: The purpose of this research is to predict the activity of 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid. Method: It was carried out using the Pass Online Prediction, Autodock 1.5.7, Discovery Studio and Maestro

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2

Lee, D. Y., S. Tachibana, M. Sumimoto, and H. Ohe. "Structure of 4'-acetoxy-3'-methoxycinnamic acid." Acta Crystallographica Section C Crystal Structure Communications 44, no. 7 (1988): 1240–42. http://dx.doi.org/10.1107/s0108270188002513.

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3

Marentek, Erika Christy, Tutuk Budiati, and Juni Ekowati. "Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 9, no. 1 (2022): 32–38. http://dx.doi.org/10.20473/jfiki.v9i12022.32-38.

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Background: Cinnamic acid and its derivatives have been widely studied for their efficacy because of the pharmacological effect on good health and well being. Microwave irradiation is more time effective to synthesize than conventional heating method because it conducts heat faster and shortens the reaction time. Objective: This study aimed to synthesize 4-hydroxy-3-methoxycinnamic acid using microwave irradiation and its antiplatelet activity by blood clotting time method. Methods: Synthesis of 4-hydroxy-3-methoxycinamic acid with malonic acid and 4-hydroxy-3-methoxybenzalehyde as a starting

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4

Wang, Xiaozhen, Xican Li, and Dongfeng Chen. "Evaluation of Antioxidant Activity of Isoferulic Acid in vitro." Natural Product Communications 6, no. 9 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600919.

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Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity of IFA has not been measured. In this study, IFA was systematically evaluated for its in vitro antioxidant activity for the first time. IC50 values were calculated of 7.30±0.57, 4.58±0.17, 1.08±0.01, 8.84±0.43, 7.69±0.39, 1.57±0.2, 13.33±0.49 μg/mL, respectively, for lipid peroxidation, DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS

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5

Schrader, A., J. Jakupovic, and W. Baltes. "Photochemical reaction products of 4-methoxycinnamic acid-3′-methylbutyl ester." Tetrahedron Letters 35, no. 8 (1994): 1169–72. http://dx.doi.org/10.1016/0040-4039(94)88015-8.

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6

Yang, Shu-Ping, Li-Jun Han, Hai-Tao Xia, and Da-Qi Wang. "Hydrogen-bonded chains of rings in (E)-4-methoxycinnamic acid." Acta Crystallographica Section E Structure Reports Online 62, no. 11 (2006): o5141—o5143. http://dx.doi.org/10.1107/s1600536806042735.

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7

Hidalgo, William, Marco Kai, and Bernd Schneider. "4-Methoxycinnamic acid - An unusual phenylpropanoid involved in phenylphenalenone biosynthesis in Anigozanthos preissii." Phytochemistry 117 (July 25, 2015): 476–81. https://doi.org/10.1016/j.phytochem.2015.05.017.

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Hidalgo, William, Kai, Marco, Schneider, Bernd (2015): 4-Methoxycinnamic acid - An unusual phenylpropanoid involved in phenylphenalenone biosynthesis in Anigozanthos preissii. Phytochemistry 117: 476-481, DOI: 10.1016/j.phytochem.2015.05.017, URL: https://www.mendeley.com/catalogue/bca9dfba-e693-3bf4-ac9e-4aef0fef0fc8/

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8

Ferenc, Wiesława, Beata Cristóvão, Jan Sarzyński, and Paweł Sadowski. "Complexes of the selected transition metal ions with 4-methoxycinnamic acid." Journal of Thermal Analysis and Calorimetry 110, no. 2 (2011): 739–48. http://dx.doi.org/10.1007/s10973-011-1935-5.

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9

Ainurrizma, Dhea Ananda, Juni Ekowati, Denayu Pebrianti, et al. "Molecular docking of ferulic acid analogue compounds against epidermal growth factor receptor as a potential therapy for breast cancer." Pharmacy Education 24, no. 3 (2024): 185–90. http://dx.doi.org/10.46542/pe.2024.243.185190.

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Background: Triple-negative breast cancer (TNBC) accounted for 18.1% of the breast cancer cases that occurred in Indonesia until 2020. Epidermal growth factor receptor (EGFR) overexpression is found in at least 50% of TNBC cases. So far, it is necessary to find an anti-cancer compound that has the potential against TNBC-type breast cancer to achieve good health and well-being. Objective: Ferulic acid derivatives were designed to be active on EGFR in silico study. Methods: Molecular docking was performed using Auto Dock 1.5.7 and PyRx 0.8 software, and visualisation was observed using Discovery

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10

Suhaili, Refilda, Lucy Prima Ardi, Emil Salim, and Mai Efdi. "Analisis GC-MS ekstrak tanaman terfermentasi (ETT) dari kulit buah jengkol (Pithecellobium jiringa Prain)." CHEMPUBLISH JOURNAL 5, no. 1 (2020): 36–45. http://dx.doi.org/10.22437/chp.v5i1.7957.

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Analysis of active compounds in fermented plant extract (FPE) from the ngapi nut peel using Effective Microorganism-4 (EM-4) has been done by Gas Chromatography-Mass Spectroscopy (GC-MS). There were 88 compounds found in fermented plant extract, the major content with the area above 1% were 7 compounds such as succinic acid; ethyl hydrogen succinate; 1,2,3-benzetriol; 3,3-dimethylhexanal; L-proline, 1-methyl-5-oxo-methyl ester; 3-methoxycinnamic acid and hexadecanoic acid. Based GC-MS analysis, fermented plant extract indicated that several compounds that have potential as biopesticides.

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11

Wang, Yuwei, Min Yin, Lingwen Gu, et al. "The therapeutic role and mechanism of 4-Methoxycinnamic acid in fungal keratitis." International Immunopharmacology 116 (March 2023): 109782. http://dx.doi.org/10.1016/j.intimp.2023.109782.

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12

SCHRADER, A., J. JAKUPOVIC, and W. BALTES. "ChemInform Abstract: Photochemical Reaction Products of 4-Methoxycinnamic Acid 3- Methylbutyl Ester." ChemInform 25, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.199428093.

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13

A., S. Kulkarni, K. Bongan B., G. Gavali P., and N. T. Patel (Mrs.). "Kinetics and mechanism of oxidation of syringic acid and 4-methoxycinnamic acid by dichromate in presence and absence of succinic acid." Journal of Indian Chemical Society Vol. 89, Oct 2012 (2012): 1347–50. https://doi.org/10.5281/zenodo.5770418.

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Department of Chemistry and Physics, B. S. College, Basmath-431 512, Dist. Hingoli, Maharashtra, India <em>E-mail</em> : as_kulkarni123@rediffmail.com Department of Chemistry, Yeshwant College, Nanded-431 602, Maharashtra, India <em>Manuscript received 27 January 2011, accepted 09 January 2012</em> The effect of varying concentration of [substrate], [oxidant], [H<sup>+</sup>], added neutral salt have been studied. It has been found that, the order of reaction with respect to [oxidant] and [substrate] found to be unity from the slope of plots log <em>k</em> vs log [sub]. The rate of reaction in

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14

Jeong, Yongwoo, Ho Jung Bae, Keontae Park, et al. "4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice." Journal of Ethnopharmacology 285 (March 2022): 114864. http://dx.doi.org/10.1016/j.jep.2021.114864.

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15

Hidalgo, William, Marco Kai, and Bernd Schneider. "4-Methoxycinnamic acid – An unusual phenylpropanoid involved in phenylphenalenone biosynthesis in Anigozanthos preissii." Phytochemistry 117 (September 2015): 476–81. http://dx.doi.org/10.1016/j.phytochem.2015.07.017.

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16

K., D. BANERJI, R. CHATTERJI (Miss), RANGACHARI K., C. DAS S., and K. D. MAZUMDAR A. "Syntheses of some Cinnamoylcoumaran-3-ones." Journal of Indian Chemical Society Vol.66, Nov 1989 (1989): 800–801. https://doi.org/10.5281/zenodo.6076309.

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Chemical Laboratory, P. G. Department of Chemistry, Bhagalpur University, Bhagalpur-812 007  <em>Manuscript received 3 March 1989, accepted 18 June 1989</em> <strong>Five 4'-methoxypheny1-2-cinnanioyloxyacetophenones have been obtained by reaction </strong><strong>of the related hydroxyacetophenones with <em>p</em>-methoxycinnamic acid using pyridine as a solvent and POCl<sub>3</sub>. Bromination with CuBr<sub>2</sub> yielded the </strong><strong>ω</strong><strong>-bromo-ester, which on </strong><strong>Baker-Venkataraman rearrangement gave the title compounds, the structures of

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17

Jiang, Zhi Hong, Shao Kui Zeng, Chao Hua Zhang, and Wen Long Wu. "Effect of Transglutaminase and 4-hydroxy-3-methoxycinnamic Acid on the Properties of Film from Tilapia Skin Gelatin." Advanced Materials Research 781-784 (September 2013): 623–27. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.623.

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The effect of modification with transglutaminase (TGase) and 4-hydroxy-3-methoxycinnamic acid (ferulic acid) on properties of tilapia skin gelatin film (TSGF) was researched. The results showed that the peroxide inhibition of modified TSGF increased from 14.7% to 62.0% and 52.1%, when concentrations of TGase and ferulic acid were 0.20 or 1.0 mg·mL-1. At the same time, the WVP coefficients were lower about 24.2% and 20.6%, respectively. The solubility of TSGF decreased with the increase in concentration of TGase and ferulic acid. As the formation of hydrogen bonds in the structure of the film,

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18

Kinart, Zdzisław, та Renato Tomaš. "Studies of the Formation of Inclusion Complexes Derivatives of Cinnamon Acid with α-Cyclodextrin in a Wide Range of Temperatures Using Conductometric Methods". Molecules 27, № 14 (2022): 4420. http://dx.doi.org/10.3390/molecules27144420.

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The electrical conductivities of aqueous solutions of sodium salts of trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid) with α-cyclodextrin were measured in the temperature range of 288.15 K–318.15 K. For the first time in the literature, using the limiting molar conductivity (Λmo) obtained from conductivity measurements, the values of the complexation constants (Kf) of the salts of phenolic acid derivatives with α-cyclodex

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19

Kinart, Zdzisław. "Conductometric Studies of Formation the Inclusion Complexes of Phenolic Acids with β-Cyclodextrin and 2-HP-β-Cyclodextrin in Aqueous Solutions". Molecules 28, № 1 (2022): 292. http://dx.doi.org/10.3390/molecules28010292.

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An attempt was made to evaluate the possibility of creating and assessing the stability of inclusion complexes of selected phenolic acids [trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid)] with β-cyclodextrin and 2-HP-β-cyclodextrin in aqueous solutions in a wide temperature range 283.15 K–313.15 K. On the basis of the values of the limiting molar conductivity (LCDNaDod), calculated from the experimental data, the values o

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20

He, Qing-Lin, Shu Yin, and Tsugio Sato. "Synthesis and Photochemical Properties of Layered Double Hydroxide Intercalating 4-Hydroxy-3-Methoxycinnamic Acid." Solid State Phenomena 90-91 (April 2003): 51–56. http://dx.doi.org/10.4028/www.scientific.net/ssp.90-91.51.

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21

Mishra, Sunil Kumar. "Electro-Chemical and Spectroscopic Properties of Trans-4-Methoxycinnamic Molecule: A DFT Study." International Journal of Research and Scientific Innovation XII, no. VI (2025): 862–68. https://doi.org/10.51244/ijrsi.2025.12060069.

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This study investigates the structural, electronic, and vibrational properties of trans-4-methoxycinnamic acid using Density Functional Theory (DFT). The molecule’s optimized geometry, analyzed with the B3LYP functional and 6-311G(d,p) basis set, reveals a planar, conjugated structure with significant stability and delocalized π-electrons. Key electronic properties, including the HOMO-LUMO energy gap (4.2885 eV), chemical descriptors, and frontier molecular orbitals, highlight its suitability for optoelectronic and UV-absorbing applications. Vibrational analysis through IR and Raman spectra co

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22

K., D. BANERJI, R. CHATTERJI (Miss), RANGACHARI K., C. DAS S., and K. D. MAZUMDAR A. "Syntheses of some Cinnamoylcoumaran-3-ones." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 800–801. https://doi.org/10.5281/zenodo.5996332.

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Chemical Laboratory, P. G. Department of Chemistry, Bhagalpur University, Bhagalpur-812 007 <em>Manuscript received 3 March 1989, accepted 18 June 1989</em> <strong>Five 4'-methoxypheny1-2-cinnanioyloxyacetophenones have been obtained by reaction of the related bydroxyacetophenones with <em>p</em>-methoxycinnamic acid using pyridine as a solvent and POC1<sub>3</sub>. Bromination with CuBr, yielded the ω-bromo-ester, which on Baker-Venkataraman rearrangement gave the title compounds, the structures of which were confirmed by analysis and spectral data</strong>

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23

Faulds, C. B., and G. Williamson. "The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes." Journal of General Microbiology 137, no. 10 (1991): 2339–45. http://dx.doi.org/10.1099/00221287-137-10-2339.

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24

Watanabe, Satoru, Shoichi Sato, Sumika Nagase, Kazuaki Shimosato, and Taiichi Saito. "Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid." Anti-Cancer Drugs 7, no. 8 (1996): 866–72. http://dx.doi.org/10.1097/00001813-199611000-00008.

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25

K., D. BANERJI, R. CHATTERJI (Miss), RANGACHARI K., DAS S.C., and K. D. MAZUMDAR A. "Syntheses of some Cinnamoylcoumaran-3-ones." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 800–801. https://doi.org/10.5281/zenodo.6090820.

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Chemical Laboratory. P. G. Department of Chemistry, Bhagalpur University, Bhagalpur-812 007 <em>Manuscript received 3 March 1989, accepted 18 June 1989</em> Five 4'-methoxyphenyl-2-cinnamoyloxyacetophenones have been obtained by reaction of the related hydroxyacetophenones with <em>p</em>-methoxycinnamic acid using pyridine as a solvent and POCI<sub>3</sub>. Bromination with CuBr<sub>1  </sub>yielded the <em>\(\mathfrak{w}\)</em>·bromo-ester, which on Baker-Venkataraman rearrangement gave the title compounds, the structures of which were confirmed by analysis and spectral

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26

Szwajgier, Dominik. "Anticholinesterase Activity of Phenolic Acids and their Derivatives." Zeitschrift für Naturforschung C 68, no. 3-4 (2013): 125–32. http://dx.doi.org/10.1515/znc-2013-3-408.

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The ability of 36 phenolic acids and their derivatives to inhibit acetyl- and butyrylcholinesterase was studied. The most efficient acetylcholine inhibitors were: carnosic acid = gentisic acid > 3-hydroxy-4-methoxycinnamic acid = ethyl ferulate = ethyl vanillate = nordihydroguaiaretic acid > ethyl 4-hydroxybenzoate = methyl ferulate. The order of effectiveness towards butyrylcholinesterase was: carnosic acid > nordihydroguaiaretic acid = ethyl ferulate > salicylic acid > gentisic acid > rosmarinic acid = caftaric acid > homogentisic acid. The inhibitory activity was depend

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27

AVIJIT, BANERJl, JANA SUKLA, and RANABIR SUR KUMAR. "Reaction of Cinnamic Acid Derivatives with Sodium Naphthalenide, A Single-electron Transfer Reagent." Journal Of Indian Chemical Society Vol. 66, Aug-Oct 1989 (1989): 664–72. https://doi.org/10.5281/zenodo.6023992.

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Centre of Advanced Studies on Natural Products, Department of Chemistry University of Calcutta 92 Acharya Prafulla Chandra Road, Calcutta- 700 009 The reactions of the piperidides of cinnamic acid, <em>p</em>-methoxycinnamic acid and 3,4-dimethoxycinnamic acid with the single-electron transfer reagent sodium naphthalenide was investigated. Three products were obtained in each case-the corresponding dihydro- erivative and two diastereoisomeric piperidides of 3,4-diaryl- 1,6-hexanedioic acid resulting from reductive dimerisation. The <em>ß,ß'</em>- rather than  \(\

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28

Md Moniruzzaman, Md Ruhul Kuddus, Md Al Amin Sikder, AM Sarwaruddin Chowdhury, and Mohammad A. Rashid. "Steroid, Triterpenoid and Phenylpropanoid From Stereospermum Suaveolens (Roxb.) DC Growing in Bangladesh." Bangladesh Journal of Botany 50, no. 4 (2021): 1191–94. http://dx.doi.org/10.3329/bjb.v50i4.57088.

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The study was carried out to investigate the composition of natural compounds of methanol extract of leaf and stem bark of Stereospermum suaveolens (Roxb.) DC by repeated chromatographic separation and purification processes over silica gel. The phytochemical investigation resulted in the isolation of a total of three compounds, which were identified as stigmasterol (1), β-amyrin (2) and 4-methoxycinnamic acid (3). The chemical structures of the isolated compounds were elucidated by analyses of their physical properties, acquired 1H NMR data and comparison with published reports. Among these,

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Zeringue Jr., H. J., E. J. Conkerton, and D. C. Chapital. "Specific cotton leaf responses to wounding and treatment with cell-free extracts of Aspergillus flavus." Canadian Journal of Botany 63, no. 12 (1985): 2470–72. http://dx.doi.org/10.1139/b85-354.

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When initial true leaves of 1-month postemergence Acala SJ-2 cotton plants were wounded by gentle abrasion, accumulations of ferulic acid (4-hydroxy-3-methoxycinnamic acid) were detected on the 3rd and 4th days after treatment. When similar wounds were immediately treated with cell-free extracts of Aspergillus flavus mycelia, elevated levels of scopoletin (6-methoxy-7-hydroxycoumarin) were produced, beginning 1 day after treatment and continuing for 7 days. Elevated levels of scopoletin were not detected in leaves that were only wounded, and enhanced quantities of ferulic acid were not observe

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30

Sone, Atsushi, Taiichi Saito, Tsutomu Nohno, and Satoru Watanabe. "Effect of trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) on the polyamines level in the rat ventral prostate." Japanese Journal of Pharmacology 40 (1986): 220. http://dx.doi.org/10.1016/s0021-5198(19)59407-0.

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31

SONE, Atsushi. "Effect of trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) on the polyamines level in the rat ventral prostate." Folia Pharmacologica Japonica 89, no. 4 (1987): 169–73. http://dx.doi.org/10.1254/fpj.89.169.

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32

Kinyua, Ann W., Chang Mann Ko, Khanh V. Doan, et al. "4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1." Experimental & Molecular Medicine 50, no. 2 (2018): e437-e437. http://dx.doi.org/10.1038/emm.2017.253.

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Pebrianti, Denayu, Juni Ekowati та Dhea Ananda Ainurrizma. "Molecular Docking Study of Ferulic Acid Analog Compounds as Lung Antifibrotic at TGF-β1 Receptors". Berkala Ilmiah Kimia Farmasi 10, № 1 (2023): 7–12. http://dx.doi.org/10.20473/bikfar.v10i1.45430.

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Pulmonary fibrosis is one of the conditions that occur in Post-COVID Syndrome patients. Development of specific treatment as an agent to treat pulmonary fibrosis is still ongoing. Ferulic acid is a compound that has a potential lung antifibrotic agent through inhibition of TGF-β1-mediated signaling. Molecular docking studies using the AutoDock Tools program version 1.5.7 were conducted on ferulic acid and its analogs to determine the activity of compounds as antifibrotic. Furthermore, the interaction of the compound with the receptor was visualized using the Discovery Studio 2021 program. The

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Helilusiatiningsih, Nunuk. "IDENTIFIKASI SENYAWA KIMIA PADA BUAH SEGAR TERUNG POKAK (Solanum torvum) DENGAN METODE LCMS." Journal of Food Technology and Agroindustry 3, no. 1 (2021): 1–12. http://dx.doi.org/10.24929/jfta.v3i1.1179.

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The content of antioxidant compounds in pokak eggplant (Solanum torvum) had the potential as an herbal medicine and was consumed by the world population. The research objective was to study the chemical compound content of the LCMS method. Experimental design with fresh fruit extraction of pokak eggplant using 95% ethanol solvent. The parameters measured were the chemical components found in fresh fruit. The results of analysis of chemical compounds include Choline, Proline, Bis (2-ethylhexyl) phthalate, BMK ethyl glycidate, 4- Methoxycinnamic acid, chlorogenic acid, 7- Hydroxycoumarine, Trigo

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Ranušová, Petra, Ildikó Matušíková, and Peter Nemeček. "Optimization of Plant Extract Purification Procedure for Rapid Screening Analysis of Sixteen Phenolics by Liquid Chromatography." Separations 8, no. 2 (2021): 13. http://dx.doi.org/10.3390/separations8020013.

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A solid-phase extraction (SPE) procedure was developed for simultaneous monitoring of sixteen different phenolics of various polarity, quantified by high-performance liquid chromatography (HPLC). The procedure allowed screening the accumulation of intermediates in different metabolic pathways that play a crucial role in plant physiology and/or are beneficial for human health. Metabolites mostly involved in phenylpropanoid, shikimate, and polyketide pathways comprise chlorogenic acid, gentisic acid, vanillic acid, caffeic acid, protocatechuic acid, ferulic acid, rutin, quercetin, epicatechin, g

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Gackowska, Alicja, Maciej Przybyłek, Waldemar Studziński, and Jerzy Gaca. "Experimental and theoretical studies on the photodegradation of 2-ethylhexyl 4-methoxycinnamate in the presence of reactive oxygen and chlorine species." Open Chemistry 12, no. 5 (2014): 612–23. http://dx.doi.org/10.2478/s11532-014-0522-6.

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Abstract2-Ethylhexyl 4-methoxycinnamate (EHMC) is one of the most commonly used sunscreen ingredient. In this study we investigated photodegradation of EHMC in the presence of such common oxidizing and chlorinating systems as H2O2, H2O2/HCl, H2O2/UV, and H2O2/HCl/UV. Reaction products were detected by gas chromatography with a mass spectrometric detector (GC-MS). As a result of experimental studies chloro-substituted 4-methoxycinnamic acid (4-MCA), 4-methoxybenzaldehyde (4-MBA) and 4-methoxyphenol (4-MP) were identified. Experimental studies were enriched with DFT and MP2 calculations. We foun

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Hamdan, Lamia, Zoheir Arrar, Yacoub Al Muataz, et al. "Alpha Cyano-4-Hydroxy-3-Methoxycinnamic Acid Inhibits Proliferation and Induces Apoptosis in Human Breast Cancer Cells." PLoS ONE 8, no. 9 (2013): e72953. http://dx.doi.org/10.1371/journal.pone.0072953.

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38

Ohue-Kitano, Ryuji, Satsuki Taira, Keita Watanabe, et al. "3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice." Nutrients 11, no. 5 (2019): 1036. http://dx.doi.org/10.3390/nu11051036.

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4-Hydroxy-3-methoxycinnamic acid (HMCA), a hydroxycinnamic acid derivative, is abundant in fruits and vegetables, including oranges, carrots, rice bran, and coffee beans. Several beneficial effects of HMCA have been reported, including improvement of metabolic abnormalities in animal models and human studies. However, its mitigating effects on high-fat diet (HFD)-induced obesity, and the mechanism underlying these effects, remain to be elucidated. In this study, we demonstrated that dietary HMCA was efficacious against HFD-induced weight gain and hepatic steatosis, and that it improved insulin

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Komala, Ismiarni, Muhamad Beny Setiawan, and Yardi Yardi. "Optimization of Reaction Condition for Synthesis of 4-Methoxychalcone from Ethyl p-methoxycinnamate." Pharmaceutical and Biomedical Sciences Journal (PBSJ) 4, no. 2 (2023): 85–90. http://dx.doi.org/10.15408/pbsj.v4i2.30028.

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Ethyl p-methoxycinnamate (1) is the main secondary metabolite found in Kaempferia galanga Linn and has various interesting pharmacological activities, including anti-inflammatory, sedative, vasorelaxant, and antiangiogenic activities. This study aimed to optimize the conditions for the conversion of 1 to 4-methoxychalcone (2) using a conventional synthetic reaction. The conversion was initiated by the hydrolysis of 1 to p-methoxycinnamic acid (3) and 3 to 4-methoxybenzaldehyde (4), and continued with the Claisen-Schmidt reaction of 4 with acetophenone (5). The temperature (room temperature and

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Sıdır, İsa, and Yadigar Gülseven Sıdır. "Investigation on the interactions of E -4-methoxycinnamic acid with solvent: Solvatochromism, electric dipole moment and pH effect." Journal of Molecular Liquids 249 (January 2018): 1161–71. http://dx.doi.org/10.1016/j.molliq.2017.11.136.

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Shi, Jie, Qiang Wu, Jiliang Deng, et al. "Metabolic Profiling and Antioxidant Analysis for the Juvenile Red Fading Leaves of Sweetpotato." Plants 11, no. 22 (2022): 3014. http://dx.doi.org/10.3390/plants11223014.

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Leaves of sweetpotato (Ipomoea batatas L.) are promising healthy leafy vegetable. Juvenile red fading (JRF) leaves of sweetpotato, with anthocyanins in young leaves, are good candidates for developing functional vegetables. Here, metabolic profiling and possible antioxidants were analyzed for five leaf stages of the sweetpotato cultivar “Chuanshan Zi”. The contents of anthocyanins, total phenolics, and flavonoids all declined during leaf maturation, corresponding to declining antioxidant activities. By widely targeted metabolomics, we characterized 449 metabolites belonging to 23 classes. A to

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Eliašová, Adriana, Miroslav Repčák, and Andrea Pastírová. "Quantitative Changes of Secondary Metabolites of Matricaria chamomilla by Abiotic Stress." Zeitschrift für Naturforschung C 59, no. 7-8 (2004): 543–48. http://dx.doi.org/10.1515/znc-2004-7-817.

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AbstractThe responses of young plants of diploid and tetraploid Matricaria chamomilla cultivars to abiotic stress were studied. The course of quantitative changes of main leaf secondary metabolites was evaluated within an interval from 6 h before to 54 h after spraying the leaf rosettes with aqueous CuCl2 solution. The content of herniarin in the treated plants rose approximately 3 times, simultaneously with a decline of its precursor (Z)- and (E)-2-β-ᴅ-glucopyranosyloxy- 4-methoxycinnamic acid. The highest amounts of umbelliferone in stressed plants exceeded 9 times and 20 times those observe

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Sundaram S, Vasanthi T, Jayaprakash T, Balasubramanian V, and Vijayakumar V N. "Optical and thermal studies on binary liquid crystal mixture." Nanoscale Reports 4, no. 1 (2021): 40–51. http://dx.doi.org/10.26524/nr.4.7.

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The novel binaryliquid crystal mixture is designed and synthesized from 4-methoxycinnamic acid (MCA) and 4-ethoxycinnamic acid (ECA). Quantum chemical (DFT) calculation for MCA+ECA geometry is optimized by DFT/B3LYP with 6-311G (d, p) basis set and its results are good agreement with experimental data. Fourier-transform infrared spectroscopic(FT-IR) study confirm the presence of intermolecular hydrogen bond in the liquid crystal mixture .The paramorphic changes in nematic phase and thermo-optic properties of binary liquid crystal mixture isanalyzed using polarizing opti

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Ekowati, Juni, Marcellino Rudyanto, Shigeru Sasaki, et al. "Structure Modification of Ethyl p-methoxycinnamate Isolated from Kaempferia galanga Linn. and Citotoxicity Assay of The Products on WiDr Cells." Indonesian Journal of Cancer Chemoprevention 1, no. 1 (2010): 12. http://dx.doi.org/10.14499/indonesianjcanchemoprev1iss1pp12-18.

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Ethyl p-methoxycinnamate, major ingredient of Kaempferia galanga rhizome, have been reported not only has analgesic – anti inflammatory activities like NSAIDs which inhibited cyclooxygenase, but also inhibit tumor cell proliferation in specimen of mouse epidermis. Therefore, it will be interesting to carry out synthetic studies on the derivates of ethyl p-methoxycinnamate and searching their citotoxic activity on WiDr cell. We wish to report of structure modification on carboxyl moiety of ethyl p-methoxycinnamate and evaluation on their citotoxic activity on WiDr cell. Isolation of ethyl p-met

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Anzano, Attilio, Laura Grauso, Bruna de Falco, and Virginia Lanzotti. "Untargeted LC-HRMS Metabolomics and Chemometrics of Aloe vera Across Diverse Geographical Origins and Cultivation Practices." Plants 14, no. 11 (2025): 1685. https://doi.org/10.3390/plants14111685.

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The chemical composition of Aloe vera leaves was investigated by using liquid chromatography–high-resolution tandem mass spectrometry (LC-HRMS/MS). Five A. vera samples were collected across diverse geographical origins and cultivation practices: PO (Botanical Garden of Portici, Italy), CAN (Gran Canaria, Canary Islands), CA, E, and MM (Marine Reserve of Torre Guaceto, Brindisi, Italy). Analysis of hydroalcoholic organic extracts revealed 77 organic compounds, including ubiquitous primary metabolites (i.e., sugars, amino acids, and fatty acids) and natural products (i.e., phenols and aromatics

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Herdiansyah, Mochammad A., Rafli Rizaldy, Mochamad RT Alifiansyah, et al. "Molecular interaction analysis of ferulic acid (4-hydroxy-3-methoxycinnamic acid) as main bioactive compound from palm oil waste against MCF-7 receptors: An in silico study." Narra J 4, no. 2 (2024): e775. http://dx.doi.org/10.52225/narra.v4i2.775.

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Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical compound that is commonly found in conjugated forms within mono-, di-, polysaccharides and other organic compounds in cell walls of grain, fruits, and vegetables. This compound is highly abundant in the palm oil waste. The aim of the study was to predict the anticancer activity of ferulic acid against the breast cancer cell lines (MCF-7) receptors through a computational analysis. MCF-7 receptors with PDB IDs of 1R5K, 2IOG, 4IV2, 4IW6, 5DUE, 5T92, and 5U2B were selected based on the SMILE similarity of the native ligand. Therea

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Peng, Chiung-Chi, Charng-Cherng Chyau, Hui-Er Wang, et al. "Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/579859.

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Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures. To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems,

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Yu, P., J. J. McKinnon, D. D. Maenz, V. J. Racz, and D. A. Christensen. "The interactive effects of enriched sources of Aspergillus ferulic acid esterase and Trichoderma xylanase on the quantitative release of hydroxycinnamic acids from oat hulls." Canadian Journal of Animal Science 82, no. 2 (2002): 251–57. http://dx.doi.org/10.4141/a01-035.

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Oat hulls contain relatively high amounts of hydroxycinnamic acids, mainly ferulic (4-hydroxy-3-methoxycinnamic) and p-coumaric acids (4-hydroxy-cinnamic), which are inhibitory to cell wall biodegradability by rumen microorganisms. In this paper, a study of the interactive effects of enriched sources of Aspergillus ferulic acid esterase (A-FAE) and Trichoderma xylanase (T-XYL) at different levels on the quantitative release of ferulic acid and p-coumaric acid from oat hulls was carried out. The results show that relative to A-FAE alone, the combined action of A-FAE and T-XYL was superior in ca

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Suhendy, Hendy, Muhamad Insanu, and Irda Fidrianny. "Extracts, Fractions, and Subfractions from Purple-Orange Sweet Potato (Ipomoea batatas L.): Xanthine Oxidase Inhibitory Potential and Antioxidant Properties." Molecules 30, no. 11 (2025): 2442. https://doi.org/10.3390/molecules30112442.

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Previous research has shown that fractions outperformed extracts in pharmacological activity and safety. This study assessed the total phenol and flavonoid content, as well as antioxidant and xanthine oxidase inhibitory (XOI) activities, of purple-orange sweet potato extracts, fractions, and subfractions. Using UV-visible spectrophotometry, the leaves showed the highest values for total phenol, flavonoid, 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Power (FRAP), Cupric Ion Reducing Antioxidant Capacity (CUPRAC) assays, and XOI activity. The sequential extraction of the le

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Nuzul, Mohd Izuddin, Vivien Yi Mian Jong, Lee Feng Koo, et al. "Effects of Extraction Methods on Phenolic Content in the Young Bamboo Culm Extracts of Bambusa beecheyana Munro." Molecules 27, no. 7 (2022): 2359. http://dx.doi.org/10.3390/molecules27072359.

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Nowadays, many studies focus on the potential of bamboo as a source of bioactive compounds and natural antioxidants for nutraceutical, pharmaceutical, and food sources. This study is a pioneering effort to determine the total phenolic content, total flavonoid content and free radical scavenging activity, as well as the phenolic identification and quantification of Bambusa beecheyana. The study was conducted by using ethanol, methanol, and water for solvent extraction by applying cold maceration, Soxhlet, and ultrasonic-assisted extraction techniques. The results showed that Soxhlet and ultraso

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