Academic literature on the topic '4-naphthoquinone derivatives'

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Journal articles on the topic "4-naphthoquinone derivatives"

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Ma, Qinge, Rongrui Wei, and Zhipei Sang. "Structural Characterization and Hepatoprotective Activity of Naphthoquinone From Cucumis bisexualis." Natural Product Communications 15, no. 1 (2020): 1934578X2090289. http://dx.doi.org/10.1177/1934578x20902898.

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Three new naphthoquinones, namely 5,8-dihydroxy-7′-isopropyl-furan ring-1″-prenyl-naphthoquinone (1), 5,8-dihydroxy-7′-propenyl-furan ring-1″-isopropanol-naphthoquinone (2), and 5,8-dihydroxy-7′-isopropanol-furan ring-1″-(5″-hydroxyphenyl)-naphthoquinone (3), along with 10 known naphthoquinone derivatives (4-13) were isolated from Cucumis bisexualis for the first time. All the compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Compounds (1-13) were evaluated for their hepatoprotective activites on human L-O2 cells. Among them, compounds 1, 4, and 8 exh
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Rakesh, Kumar Sahu, Kumari Khushbu, Kumari Pooja, et al. "A Review on Properties and Pharmacological Activity of Naphthoquinone and its Derivatives." Chemistry Research Journal 10, no. 2 (2025): 87–94. https://doi.org/10.5281/zenodo.15606076.

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Naphthoquinone forms the central chemical structure of many natural compounds, most notably the K Vitamins. 2-Methylnaphthoquinone is a more effective coagulant than vitamin K. Naphthoquinone derivatives are cytotoxic, they have significant antibacterial, antifungal, antiviral, insecticidal, anti-inflammatory, and antipyretic properties. Quinone derivatives may be toxic to cells by a number of mechanisms including redox cycling, arylation, intercalation, induction of DNA strands breaks, generation of free radicals and alkylation via quinone methide formation. 5-Hydroxy-1, 4-naphthoquinone, jug
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Aseeva, Natalia V., Nadezhda V. Danilenko, Evgenii V. Plotnikov, et al. "Synthesis of New 1,4-Naphthoquinone Fluorosulfate Derivatives and the Study of Their Biological and Electrochemical Properties." International Journal of Molecular Sciences 25, no. 22 (2024): 12245. http://dx.doi.org/10.3390/ijms252212245.

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This study presents the synthesis of new fluorosulfate derivatives of 1,4-naphthoquinone by the SuFEx reaction. Anticancer properties of obtained compounds were studied on PC-3 (prostate adenocarcinoma), SKOV-3 (ovarian cancer), MCF-7 (breast cancer), and Jurkat cell lines. All the studied compounds showed higher cytotoxic effects than Cisplatin. The DFT method was applied to determine the electronic structure characteristics of 1,4-naphthoquinone derivatives associated with cytotoxicity. A method of determination of 2,3-dichloro-1,4-naphthoquinone (NQ), 3-chloro-2-((4-hydroxyphenylamino)-1,4-
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Ourhzif, El-Mahdi, Caroline Decombat, Isabelle Abrunhosa-Thomas, et al. "Synthesis and Biological Evaluation of New Naphthoquinones Derivatives." Current Organic Synthesis 17, no. 3 (2020): 224–29. http://dx.doi.org/10.2174/1570179417666200212111956.

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: New substituted 1,4-naphthoquinones have been prepared in good overall yields through the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast tumor cells. The most active compound 14 displayed an IC50 of 15μM. Objective: To investigate the cytotoxicity of new naphthoquinones derivatives on MCF-7 cells. Methods: Synthesis of new naphtoquinones derivatives and in vitro evaluation of their cytotoxicity on MCF-7 cells (rezasurin cell-based assay). Results: Starting from Ethyl 4-hydroxy-6,7-dimethoxy-2-naphthoate, four naphthoquinones were prepared and exhibite
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Durán, Alexandra G., Nuria Chinchilla, Ana M. Simonet, et al. "Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds." Toxins 15, no. 5 (2023): 348. http://dx.doi.org/10.3390/toxins15050348.

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Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of researchers in recent years. In addition, it is also worth mentioning that many anticancer drugs possess a naphthoquinone backbone in their structure. Considering this background, the work described herein reports the evaluation of the cytotoxicity of different acyl and alkyl derivatives from juglone and lawsone that showed the best activity resul
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Kacmaz, Aysecik, Nahide Gulsah Deniz, Serdar Goksin Aydinli, et al. "Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells." Open Chemistry 17, no. 1 (2019): 337–45. http://dx.doi.org/10.1515/chem-2019-0030.

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AbstractIn the course of biological properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-butyl 4-aminobenzoate, 4-tert-butylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N'-diphenyl-p-phenylenediamine) and thiolat (sodium 2-methyl-2-propanethiolate). All new products were characterized by MS-ESI, UV-Vis, FT-IR, 1H NMR, 13C NMR. The antiproliferative activities of these compounds on human cervical cancer (HeLa)
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Kurka, M. S., I. R. Buchkevych, A. S. Krvavych, et al. "The study of the interaction of 1,2- and 1,4-naphthoquinones with aminophosphonic esters." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 2 (April 2024): 39–46. http://dx.doi.org/10.32434/0321-4095-2024-153-2-39-46.

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A number of new biologically active phosphorus-containing quinones were prepared by the reaction of 2,3-dichloro-1,4-naphthoquinone and sodium 1,2-naphthoquinone-4-sulfonate with phosphonate nucleophilic reagents, aminophosphonic acid esters. The structures of the synthesized compoumds were confirmed by ESI-MS, 1H NMR, IR-spectroscopies and elemental analysis. It was shown that aminophosphonic esters form products of nucleophilic substitution of a chlorine atom of 1,4-naphthoquinone or a sulfonyl group of 1,2-naphthoquinone on an aminophosphonic fragment. The products of the interaction of sod
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Ratti, Pichayaporn, Jutharat Manuschai, Jiraporn Kara, Luelak Lomlim, and Supawadee Naorungroj. "In Vitro Antimicrobial, Antiglycolytic, and Antibiofilm Activities of Synthetic 1,4-Naphthoquinone Derivatives against Cariogenic Bacteria." Sains Malaysiana 52, no. 1 (2023): 199–210. http://dx.doi.org/10.17576/jsm-2023-5201-16.

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This study investigated the potential anticaries properties of synthetic 1,4-naphthoquinone derivatives. Synthetic 1,4-naphthoquinone derivatives (2-4) were designed and synthesized by employing lawsone methyl ether (LME, 1), a plant-derived 1,4-naphthoquinone, as a lead compound. The synthetic compounds were characterized by infrared spectroscopy, 1H-nuclear magnetic spectroscopy, 13C- nuclear magnetic spectroscopy, and high-resolution mass spectrometry. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and growth curves were determined to assess their antibact
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Kim, Kyeongha, Hun Young Kim, and Kyungsoo Oh. "ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil." RSC Advances 10, no. 52 (2020): 31101–5. http://dx.doi.org/10.1039/d0ra06820a.

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Nataliia, Polish, Voitsakhivska Olha, Marintsova Nataliia, Zhurakhivska Lesya, Novikov Volodymyr, and Bohza Serhii. "Primary screening of the biological activity of heterocyclic aminoderivatives of 2,3-dichloro-1,4-naphtoquinone." ScienceRise: Pharmaceutical Science, no. 6(22) (December 30, 2019): 37–42. https://doi.org/10.15587/2519-4852.2019.188127.

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<strong>The aim.</strong>&nbsp;Check the antimicrobial and fungicidal activity of 2,3-dichloro-1,4-naphthoquinone aminopyrazole derivatives and predict their severity of toxicity to rats. <strong>Materials and methods of the research.</strong>&nbsp;The antimicrobial activity of heterocyclic amino derivatives of naphthoquinone 3a-d was studied by diffusion of the substance into agar on solid nutrient medium and by serial dilution. Acute rodent toxicity was determined by the QSAR simulation method implemented in GUSAR software. <strong>Results.</strong>&nbsp;In the work, the antimicrobial and fu
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Dissertations / Theses on the topic "4-naphthoquinone derivatives"

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Lin, Jiun-Han, and 林君翰. "Part I : One-pot Tandem Synthesis of a Coumarin / Naphthoquinone Monoimine-based Oxazabicycle and Its Fluorescence Redox-switching PropertiesPart II : Synthesis of 4-Hydroxy-7-dimethylamino-3-pyrazolinylcoumarin Derivatives and Their Solvatochromic an." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/01516014209402314283.

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碩士<br>東海大學<br>化學系<br>98<br>Part I : One-pot Tandem Synthesis of a Coumarin / Naphthoquinone Monoimine-based Oxazabicycle and Its Fluorescence Redox-switching Properties A coumarin/naphthoquinone monoimine-fused oxazabicyclic derivative was designed, synthesized, and characterized in a one-pot tandem reaction and its fluorescence redox switch properties were investigated. The coumarin emission of the synthesized oxazabicycle is completely quenched by the naphthoquinone monoimine moiety, the corresponding reduced aminonaphthalenol resulted in a moderate increase of the emission intensity. T
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Shie, Tien-Lan, and 謝天嵐. "PartⅠ、Mechanistic Studies of Isomerization of Enol Esters Derived from Triketone and Rational Design of Novel Naphthoquinone-based Derivatives as a Potential Redox Switch.PartⅡ、Efforts to Acquire the Co-crystal Structures of 4-HPPD in Complex with." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/56976275532345619819.

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碩士<br>東海大學<br>化學系<br>94<br>PartⅠ、Mechanistic Studies of Isomerization of Enol Esters Derived from Triketone and Rational Design of Novel Naphthoquinone-based Derivatives as a Potential Redox Switch. ( A ) The fluorescence-sensitive property of 3-acetyl-7-dimethylamino- 4-hydroxy-2H-chrome-2-one and its derivatives has been designed, synthesized and used to differentiate the two possible mechanisms of enol ester isomerization derived from 2-acyl-1,3-cyclohexanediones. The results suggested that the mechanism involving first 1,5-acyl transfer and following by 1,5-hydrogen shift is unlikely
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Book chapters on the topic "4-naphthoquinone derivatives"

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"Study of light-induced interaction of quinone derivatives with guanosine and guanosine-rich oligonucleotides." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.6.3.

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Quinones are a broad class of compounds of both synthetic and natural origin that are actively used in medicine, particularly in anticancer therapy. Their main mechanism of cytotoxicity is associated with interaction with DNA. This type of interaction is possible due to the flat aromatic system of quinones. Model processes of interaction of the naphthoquinone derivative N-(2-chloro-1,4- naphthoquinonyl)-b-alanine (Nap) as well as the anthraquinone 2-phenyl-4-(butylamino)- naphtholquinoline-7,12-dione (Q1) with 5'-guanidylic acid (GMP) and oligonucleotide sequences of different lengths (2G, 3G,
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