Academic literature on the topic '4-oxo-quinazolin'

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Journal articles on the topic "4-oxo-quinazolin"

1

Appani, Ramgopal, Baburao Bhukya, and Kiran Gangarapu. "Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one." Scientifica 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/1249201.

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A series of novel 3-(substituted)-2-(substituted quinazolinylamino)quinazolin-4(3H)-ones were synthesized by the reaction of 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting materials 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines by a multistep synthesis. All the title compounds were tested for their antibacterial activity using ciprofloxacin as reference standard. Compounds 3-(4-fluorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9a) and 3-(4-chlorophenyl)-2-(4-oxo-2-p
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2

H., D. Navadiya, K. Undavia N., and S. Patwa B. "Studies on synthesis of 2-methyl-3,1-benzoxazine-4(4H)-one dyes and their application on nylon and polyester fibres." Journal of Indian Chemical Society Vol. 86, Oct 2009 (2009): 1118–20. https://doi.org/10.5281/zenodo.5820642.

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Department of Chemistry, Department of Industrial Chemistry, Sir P. P. Institute of Science, Bhavnagar University, Bhavnagar-364 002, Gujarat, India <em>E-mail </em>: dr.navadiya@yahoo.com <em>Manuscript received 15 December 2008, accepted 3 July 2009</em> A series of 3-{4-[4-(4-arylazo)-benzenesulfonyl]phenyl}-2-methyl-3H-quinazolin-4-one derivatives (3) have been obtained by a reaction of a various coupling agent (a-g) with diazonium salt containing 4-oxo-quinazolin moiety (2). The diazonium salt 2 is obtained by the reaction of 4-(2-methyl-4-oxo-3-quinazolinyl)-4<em>&#39;</em>-aminodiphenyl
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3

Nancy, Sakshi Chaudhary, and Archana. "SYNTHESIS OF SOME NEWER THIAZOLIDINONYL QUINAZOLINONES AND AZETIDINONYL QUINAZOLINONES AS POTENT ANTI-INFLAMMATORY AGENTS." Indian Drugs 59, no. 08 (2022): 21–30. http://dx.doi.org/10.53879/id.59.08.13098.

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3-Substitutedphenyl-2-bromomethyl-6-substituted quinazolin-4(3H)-ones (7-10) were treated with hydrazine hydrate to give 3-substitutedphenyl-2-hydrazinomethyl-6-substituted quinazolin-4(3H)-ones (11-14). Compounds 11-14 were condensed with various aldehydes to afford 2-substitutedbenzylidene hydrazinomethyl-3-substitutedphenyl-6-substituted quinazolin-4(3H)-ones (15-22). Cycloaddition of compounds 15-22 with thioglycolic acid and triethylamine / chloroacetyl chloride yielded 2-[(4’-oxo-2’ -substitutedphenyl-thiazolidin-3’-yl)-aminomethyl]-3-substitutedphenyl-6-substituted quinazolin-4(3H)- one
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4

Raghavendra, N. M., P. P. Thampi, and P. M. Gurubasavarajaswamy. "Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones." E-Journal of Chemistry 5, no. 1 (2008): 23–33. http://dx.doi.org/10.1155/2008/410157.

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Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities.
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5

Havaldar, Freddy H., and Abhay R. Patil. "Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity." E-Journal of Chemistry 5, no. 2 (2008): 347–54. http://dx.doi.org/10.1155/2008/394737.

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Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR,1H NMR and Mass spectra. The compounds have also been screened for their biological activity.
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6

Sulthana, M. T., K. Chitra, and V. Alagarsamy. "Anti-HIV, Antitubercular and Antibacterial Activities of Novel 3-(Substituted Quinazolinylamino)-2-phenyl quinazolin-4(3H)ones." Asian Journal of Chemistry 32, no. 2 (2019): 281–86. http://dx.doi.org/10.14233/ajchem.2020.22280.

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In the present study, we have synthesized a series of novel 2-phenyl-3-(substituted quinazolinylamino)quinazolin-4(3H)-ones by the reaction of 3-(substituted)-2-hydrazinoquinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting material 3-(substituted)-2-hydrazinoquinazolin-4(3H)-ones were synthesized from various primary amines. All the synthesized compounds were screened for their antitubercular, anti-HIV and antibacterial activity against different Grampositive and Gram-negative strains by agar dilution method. Among the test compounds, 3-(4-nitrophenyl)-2-(4-oxo-2-phenylquina
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7

Molnar, Maja, Mario Komar, and Igor Jerković. "Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate." Molbank 2022, no. 3 (2022): M1434. http://dx.doi.org/10.3390/m1434.

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A green synthetic procedure was developed for the two-step synthesis of methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate from anthranilic acid, using two green chemistry approaches: utilization of the DES and microwave-induced synthesis. The first step includes a synthesis of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one which was performed in choline chloride:urea DES. In the second step S-alkylation of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one was performed in a microwave-induced reaction. The desired compound was successfully obtained in a yield of
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8

Sabo, T., D. Kut, M. Kut, M. Onysko, and V. Lendel. "TELLURO-INDUCED CYCLISATION 2-(BUT-2-ENYLTHIO)QUINOLINECARBALDEHYDE AND QUINOLINE-4-ONE." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 73–78. http://dx.doi.org/10.24144/2414-0260.2022.2.73-78.

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Aryltellurium trichlorides have proven themselves as good cyclizing reagents in electrophilic intramolecular cyclization reactions, mainly of propenyl derivatives of heterocycles. On the other hand, information on the use of butenyl derivatives in reactions with p-alkoxyphenyltellurtrichlorides is limited. In this work, the regioselectivity of the process of electrophilic intramolecular cyclization of but-2-enyl thioethers of quinoline-3carbaldehyde and quinazolin-4-one with p-methoxyphenyltellurium trichloride was investigated.&#x0D; It was established that, as a result of the tellurium-induc
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9

Alagarsamy, Veerachamy, Viswas Solomon, G. Krishnamoorthy, M. T. Sulthana, and B. Narendar. "Synthesis and antimicrobial activities of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted)thiosemicarbazide derivatives." Journal of the Serbian Chemical Society 80, no. 12 (2015): 1471–79. http://dx.doi.org/10.2298/jsc150103053a.

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A series of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides (AS1-AS10) were obtained by the reaction of 2-hydrazino- 3-benzyl quinazolin-4(3H)-one (6) with different dithiocarbamic acid methyl ester derivatives. The key intermediate 3-benzyl-2-thioxo-2,3-dihydro-1Hquinazolin-4-one (4) was obtained by reacting benzyl amine (1) with carbon disulphide and sodium hydroxide in dimethyl sulphoxide to give sodium dithiocarbamate, which was methylated with dimethyl sulfate to yield the dithiocarbamic acid methyl ester (2) and condensed with methyl anthranilate (3) in ethanol y
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10

Rajput, Chatrasal Singh, and Shiwani Singhal. "Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs." Journal of Pharmaceutics 2013 (January 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/907525.

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A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3″-chloro-2″-oxo-4″-substitutedphenylazetidin-1″-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2″-substitutedphenyl-4″-oxo-1″,3″-thiazolidin-3″-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic a
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