Log in

Relevant bibliographies by topics / 4-oxo-quinazolin / Journal articles

To see the other types of publications on this topic, follow the link: 4-oxo-quinazolin.

Journal articles on the topic '4-oxo-quinazolin'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic '4-oxo-quinazolin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Appani, Ramgopal, Baburao Bhukya, and Kiran Gangarapu. "Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one." Scientifica 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/1249201.

Full text

Abstract:

A series of novel 3-(substituted)-2-(substituted quinazolinylamino)quinazolin-4(3H)-ones were synthesized by the reaction of 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting materials 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines by a multistep synthesis. All the title compounds were tested for their antibacterial activity using ciprofloxacin as reference standard. Compounds 3-(4-fluorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9a) and 3-(4-chlorophenyl)-2-(4-oxo-2-p

APA, Harvard, Vancouver, ISO, and other styles

2

H., D. Navadiya, K. Undavia N., and S. Patwa B. "Studies on synthesis of 2-methyl-3,1-benzoxazine-4(4H)-one dyes and their application on nylon and polyester fibres." Journal of Indian Chemical Society Vol. 86, Oct 2009 (2009): 1118–20. https://doi.org/10.5281/zenodo.5820642.

Full text

Abstract:

Department of Chemistry, Department of Industrial Chemistry, Sir P. P. Institute of Science, Bhavnagar University, Bhavnagar-364 002, Gujarat, India <em>E-mail </em>: dr.navadiya@yahoo.com <em>Manuscript received 15 December 2008, accepted 3 July 2009</em> A series of 3-{4-[4-(4-arylazo)-benzenesulfonyl]phenyl}-2-methyl-3H-quinazolin-4-one derivatives (3) have been obtained by a reaction of a various coupling agent (a-g) with diazonium salt containing 4-oxo-quinazolin moiety (2). The diazonium salt 2 is obtained by the reaction of 4-(2-methyl-4-oxo-3-quinazolinyl)-4<em>'</em>-aminodiphenyl

APA, Harvard, Vancouver, ISO, and other styles

3

Nancy, Sakshi Chaudhary, and Archana. "SYNTHESIS OF SOME NEWER THIAZOLIDINONYL QUINAZOLINONES AND AZETIDINONYL QUINAZOLINONES AS POTENT ANTI-INFLAMMATORY AGENTS." Indian Drugs 59, no. 08 (2022): 21–30. http://dx.doi.org/10.53879/id.59.08.13098.

Full text

Abstract:

3-Substitutedphenyl-2-bromomethyl-6-substituted quinazolin-4(3H)-ones (7-10) were treated with hydrazine hydrate to give 3-substitutedphenyl-2-hydrazinomethyl-6-substituted quinazolin-4(3H)-ones (11-14). Compounds 11-14 were condensed with various aldehydes to afford 2-substitutedbenzylidene hydrazinomethyl-3-substitutedphenyl-6-substituted quinazolin-4(3H)-ones (15-22). Cycloaddition of compounds 15-22 with thioglycolic acid and triethylamine / chloroacetyl chloride yielded 2-[(4’-oxo-2’ -substitutedphenyl-thiazolidin-3’-yl)-aminomethyl]-3-substitutedphenyl-6-substituted quinazolin-4(3H)- one

APA, Harvard, Vancouver, ISO, and other styles

4

Raghavendra, N. M., P. P. Thampi, and P. M. Gurubasavarajaswamy. "Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones." E-Journal of Chemistry 5, no. 1 (2008): 23–33. http://dx.doi.org/10.1155/2008/410157.

Full text

Abstract:

Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities.

APA, Harvard, Vancouver, ISO, and other styles

5

Havaldar, Freddy H., and Abhay R. Patil. "Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity." E-Journal of Chemistry 5, no. 2 (2008): 347–54. http://dx.doi.org/10.1155/2008/394737.

Full text

Abstract:

Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR,1H NMR and Mass spectra. The compounds have also been screened for their biological activity.

APA, Harvard, Vancouver, ISO, and other styles

6

Sulthana, M. T., K. Chitra, and V. Alagarsamy. "Anti-HIV, Antitubercular and Antibacterial Activities of Novel 3-(Substituted Quinazolinylamino)-2-phenyl quinazolin-4(3H)ones." Asian Journal of Chemistry 32, no. 2 (2019): 281–86. http://dx.doi.org/10.14233/ajchem.2020.22280.

Full text

Abstract:

In the present study, we have synthesized a series of novel 2-phenyl-3-(substituted quinazolinylamino)quinazolin-4(3H)-ones by the reaction of 3-(substituted)-2-hydrazinoquinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting material 3-(substituted)-2-hydrazinoquinazolin-4(3H)-ones were synthesized from various primary amines. All the synthesized compounds were screened for their antitubercular, anti-HIV and antibacterial activity against different Grampositive and Gram-negative strains by agar dilution method. Among the test compounds, 3-(4-nitrophenyl)-2-(4-oxo-2-phenylquina

APA, Harvard, Vancouver, ISO, and other styles

7

Molnar, Maja, Mario Komar, and Igor Jerković. "Methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate." Molbank 2022, no. 3 (2022): M1434. http://dx.doi.org/10.3390/m1434.

Full text

Abstract:

A green synthetic procedure was developed for the two-step synthesis of methyl 2-((3-(3-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate from anthranilic acid, using two green chemistry approaches: utilization of the DES and microwave-induced synthesis. The first step includes a synthesis of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one which was performed in choline chloride:urea DES. In the second step S-alkylation of 2-mercapto-3-(3-methoxyphenyl)quinazolin-4(3H)-one was performed in a microwave-induced reaction. The desired compound was successfully obtained in a yield of

APA, Harvard, Vancouver, ISO, and other styles

8

Sabo, T., D. Kut, M. Kut, M. Onysko, and V. Lendel. "TELLURO-INDUCED CYCLISATION 2-(BUT-2-ENYLTHIO)QUINOLINECARBALDEHYDE AND QUINOLINE-4-ONE." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 73–78. http://dx.doi.org/10.24144/2414-0260.2022.2.73-78.

Full text

Abstract:

Aryltellurium trichlorides have proven themselves as good cyclizing reagents in electrophilic intramolecular cyclization reactions, mainly of propenyl derivatives of heterocycles. On the other hand, information on the use of butenyl derivatives in reactions with p-alkoxyphenyltellurtrichlorides is limited. In this work, the regioselectivity of the process of electrophilic intramolecular cyclization of but-2-enyl thioethers of quinoline-3carbaldehyde and quinazolin-4-one with p-methoxyphenyltellurium trichloride was investigated. It was established that, as a result of the tellurium-induc

APA, Harvard, Vancouver, ISO, and other styles

9

Alagarsamy, Veerachamy, Viswas Solomon, G. Krishnamoorthy, M. T. Sulthana, and B. Narendar. "Synthesis and antimicrobial activities of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted)thiosemicarbazide derivatives." Journal of the Serbian Chemical Society 80, no. 12 (2015): 1471–79. http://dx.doi.org/10.2298/jsc150103053a.

Full text

Abstract:

A series of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides (AS1-AS10) were obtained by the reaction of 2-hydrazino- 3-benzyl quinazolin-4(3H)-one (6) with different dithiocarbamic acid methyl ester derivatives. The key intermediate 3-benzyl-2-thioxo-2,3-dihydro-1Hquinazolin-4-one (4) was obtained by reacting benzyl amine (1) with carbon disulphide and sodium hydroxide in dimethyl sulphoxide to give sodium dithiocarbamate, which was methylated with dimethyl sulfate to yield the dithiocarbamic acid methyl ester (2) and condensed with methyl anthranilate (3) in ethanol y

APA, Harvard, Vancouver, ISO, and other styles

10

Rajput, Chatrasal Singh, and Shiwani Singhal. "Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs." Journal of Pharmaceutics 2013 (January 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/907525.

Full text

Abstract:

A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3″-chloro-2″-oxo-4″-substitutedphenylazetidin-1″-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2″-substitutedphenyl-4″-oxo-1″,3″-thiazolidin-3″-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic a

APA, Harvard, Vancouver, ISO, and other styles

11

Sulthana M.T, Chitra K, and Alagarsamy V. "Synthesis of novel 4-oxo-N-(4-oxo-3-substituted-3,4-dihydroquinazolin-2-yl amino)-2-phenylquinazoline-3(4H)-carboxamidines as AntiHIV, antitubercular and antibacterial agents." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 2186–92. http://dx.doi.org/10.26452/ijrps.v10i3.1449.

Full text

Abstract:

A series of novel 4-oxo-N-(4-oxo-3-substituted-3,4-dihydroquinazolin-2-yl amino)-2-phenylquinazoline-3(4H)-carboxamidines are prepared from methyl 4-oxo-2-phenylquinazoline-3(4H)-carbthioimidate & 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones. The starting material 4-oxo-2-phenylquinazoline-3(4H)-carbthioimidates were prepared from anthranilic acid while the 3-(substituted)-2-hydrazino-quinazolin-4(3H)-one was prepared from a range of 1° amines using multistep preparation. Entire synthesized analogues were screened for their antitubercular, anti-HIV and antibacterial activity. Among t

APA, Harvard, Vancouver, ISO, and other styles

12

A., M. Sanghani, B. Sanja D., R. Rajani V., and R. Godhani D. "Synthesis and biological activities of 4-oxo thiazolidine derivatives." Journal of Indian Chemical Society Vol. 85, May 2008 (2008): 557–60. https://doi.org/10.5281/zenodo.5816527.

Full text

Abstract:

Department of Chemistry, Bhavnagar University, Bhavnagar-364 002, Gujarat, India <em>E-mail :</em> drgodhani@yahoo.com <em>Manuscript received 8 February 2007, revised 1 January 2008, accepted 21 February 2008</em> A series of 4-oxo-2-phenyl-thiazolidin-3-yl derivatives 5a-1 have been obtained by cyclisation of various Schiff's base 4 with thioglycolic acid. The Schiff's base 4 are obtained by the reaction of appropriate carbonyl compound with (4-oxo-3-<em>p</em>-tolyl-3,4-dihydro-quinazolin-2-yl-sulfanyl)-acetic acid hydrazide 3. The product is characterized by spectral and analytical

APA, Harvard, Vancouver, ISO, and other styles

13

V., K. Pandey, Kumar Jitendra, K. Saxena S., Mukesh, N. Joshi M., and K. Bajpai S. "Synthesis, characterization and antiviral activity of 2,3-disubstituted quinazolones." Journal of Indian Chemical Society Vol. 84, Jun 2007 (2007): 593–97. https://doi.org/10.5281/zenodo.5820764.

Full text

Abstract:

Department of Chemistry, University of Lucknow, Lucknow-226 007, Uttar Pradesh, India <em>E-mail</em> : vinodkumarpandey@rediffmail.com Department of Chemistry, D.N.P.G. College, Gulaothi, Bu!andshahr-245 008, Uttar Pradesh, India Central Drug Research Institute, Lucknow-226 001, Uttar Pradesh, India <em>Manuscript received 10 August 2006, revised 10 April 2007, accepted 18 April 2007</em> Anthranilic acid on reaction with excess equivalent of an aromatic acid chloride in pyridine yields 2-aryl-4-oxo-3,1-benzoxazines (1). Reaction of 1 with <em>p</em>-aminophenol in pyridine furnishes 2-aryl-3

APA, Harvard, Vancouver, ISO, and other styles

14

S., G. ABDEL-HAMIDE. "Synthesis and Chemistry of some Novel 3-Heteroaryl-quinazolin-4-one Derivatives and their Antimicrobial Effects." Journal of Indian Chemical Society Vol. 74, Aug 1997 (1997): 619–23. https://doi.org/10.5281/zenodo.5891384.

Full text

Abstract:

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt <em>Manuscript received 6 March 1995, revised 18 March 1996, accepted 24 July 1996</em> Some new heteroaryl-quinazolin-4-ones have been synthesised via the interaction of 3-amino-2-phenyl-6-iodoquinazolin-4-one with some oxo-compounds. Significant <em>in vitro</em> antimicrobial activities have been observed for some members of the series.

APA, Harvard, Vancouver, ISO, and other styles

15

Debnath, Subal, and S. Y. Manjunath. "Conventional and Microwave Assisted Synthesis of 3-(Substituted)-2-phenyl quinazolin-4(3H)-one and their Antibacterial and Anthelmintic Activity." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 2 (2011): 1408–11. http://dx.doi.org/10.37285/ijpsn.2011.4.2.6.

Full text

Abstract:

The present research work was aimed to synthesize a series of various substituted quinazolinone containing 3-(substituted)-2-phenylquinazolin-4(3H)-one. The compound 3-[(2-oxo-4-phenylazetidin-1-yl)-carbonyl]-2-phenylquinazolin-4(3H)-one, II was prepared by treating 4-oxo-2-phenyl-N-[(E)-phenylmethylidene]quinazoline-3(4H)-carboxamide, I with acetyl chloride and triethylamine (TEA) in benzene by conventional and microwave irradiation method. Synthesis of 3-[{2-oxo-3-(2,4-dichlorophenoxy)-4-phenylazetidin-carbonyl]-2-phenylquinazolin-4(3H)-one, III was carried out by reacting, I with 2,4-dichlo

APA, Harvard, Vancouver, ISO, and other styles

16

Tiwari, Ram Prakash, Krishna Srivastava, Abhishek Srivastava, Shailesh Kumar Mishra, and Amit Tripathi. "Synthesis and Biological evalution of heterocyclic oxazine-2-carbonothioyl)quinazolin-4(3H)-one and oxazine-2(3H)-carbothioamide derivatives." Research Journal of Chemistry and Environment 27, no. 11 (2023): 60–71. http://dx.doi.org/10.25303/2711rjce060071.

Full text

Abstract:

An efficient route for the preparation of novel heterocyclic oxazine-carbonothioyl-quinazolin-(3H)-one and oxazine-(3H)-carbothioamide derivatives is through synthesis of 2-phenyl-4H-benzo[d][1,3] oxazin-4-one(anthranilic acid and benzoyl chlordide) which further reacts with thiourea and thiosemicarbazide to give substituted amines, which formed oxo-2-phenylquinazoline-3(4H)-carbothioa mide and oxo-2-phenylquinazolin-3(4H)-yl)thiourea (β-naphthol,substituted aromatic formedehyde). The structures of all the prepared derivatives were elucidated by using UV-Vis IR, 1HNMR and Mass spectral studies

APA, Harvard, Vancouver, ISO, and other styles

17

Aly, A. A. "Synthesis And Antimicrobial Activity Of Some Annelated Quinazoline Derivatives." Zeitschrift für Naturforschung B 61, no. 8 (2006): 1012–20. http://dx.doi.org/10.1515/znb-2006-0814.

Full text

Abstract:

A highly efficient and versatile synthetic approach to the synthesis of annelated quinazoline derivatives viz. 3,4,9,10a-tetraazaphenanthrenes 5 - 7, thiazolidinylquinazoline 9, 2,4,9,10a-tetraazaphenanthrene 11, quinazolino[4,3-b]quinazolin-8-one 12 and imidazoquinazolines 14a,b, 15. Also, a variety of pyrazolylquinazolines 19 - 21, pyrimidinylquinazolines 22a,b were obtained via a sequence of heterocyclization reactions of 4-methyl-N-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]benzenesulfonamide (2) with different reagents. The new compounds were synthesized with the objective of study their

APA, Harvard, Vancouver, ISO, and other styles

18

Kut, D. Zh, M. M. Kut, M. Yг Onysko, and V. G. Lendel. "Electrophilic cyclization of propargyl thioethers of 3-methyl(phenyl)-2-(prop-2-yn-1-ylthio)-7-(trifluoromethyl)quinazolin-4(3H)-ones by tellurium tetrahalides." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 6 (December 2021): 40–44. http://dx.doi.org/10.32434/0321-4095-2021-139-6-40-44.

Full text

Abstract:

The paper presents the results of the study of the process of electrophilic intramolecular cyclization of 3-methyl(phenyl)-2-(prop-2-yn-1-ylthio)-7-(trifluoromethyl)quinazolin-4(3H)-ones by tellurium tetrahalides. 3-Methyl(phenyl)-2-(prop-2-yn-1-ylthio)-7-(trifluoromethyl)quinazolin-4(3H)-ones were prepared by the alkylation of the corresponding thions with propargyl bromide in an alkaline alcohol medium. It is found that the interaction of propargyl thioethers of 3-substituted 2-thioxo-7-(trifluoromethyl)-2,3-dihydroquinazolin-4(1H)-ones with tellurium tetrahalides, which were obtained in sit

APA, Harvard, Vancouver, ISO, and other styles

19

Reddy, B. Srinivasa, A. Naidu, and P. K. Dubey. "Synthesis of Novel 2-(4-Oxo-3,4- Dihydroquinazolin-2-Ylsulfinylmethyl)-3H-Quinazolin-4-One." Phosphorus, Sulfur, and Silicon and the Related Elements 187, no. 5 (2012): 598–605. http://dx.doi.org/10.1080/10426507.2011.634466.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

El-Badry, Yaser A., Mahr A. El-Hashash, and Khalil Al-Ali. "Synthesis of bioactive quinazolin-4(3H)-one derivatives via microwave activation tailored by phase-transfer catalysis." Acta Pharmaceutica 70, no. 2 (2020): 161–78. http://dx.doi.org/10.2478/acph-2020-0001.

Full text

Abstract:

AbstractA series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated usin

APA, Harvard, Vancouver, ISO, and other styles

21

Rimaz, Mehdi, Jabbar Khalafy, Khadijeh Tavana, et al. "Synthesis and Single Crystal X-Ray Structure of Bis[4-oxo-3- (2-ethoxycarbonylphenyl)-3,4-dihydroquinazolin-2-yl]disulfide." Zeitschrift für Naturforschung B 64, no. 9 (2009): 1065–69. http://dx.doi.org/10.1515/znb-2009-0912.

Full text

Abstract:

Diethyl 2,2´-thiocarbonyl-bis(azanediyl)dibenzoate was synthesized from the reaction of ethyl anthranilate with thiophosgene. Its treatment with sodium ethoxide in ethanol at room temperature gave ethyl 2-(4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl) benzoate, whereas in the presence of ethyl nitroacetate and under the same reaction conditions, the corresponding bis(quinazolin)disulfide was formed. Its structure was confirmed by IR, 1H and 13C NMR spectroscopy elemental analysis and single crystal X-ray structure determination.

APA, Harvard, Vancouver, ISO, and other styles

22

Bireddy, Srinivasa Reddy, Mohammad Rafeeq, and Venkata Ramana Reddy Chittireddy. "Synthesis of 2‐(3‐methyl‐5‐oxo‐4,5‐dihydro‐1H‐pyrazol‐1‐yl) quinazolin‐4(3H)‐one derivatives." Vietnam Journal of Chemistry 59, no. 1 (2021): 73–78. http://dx.doi.org/10.1002/vjch.202000122.

Full text

Abstract:

AbstractA simple, synthesis of 2‐(3‐methyl‐5‐oxo‐4, 5‐dihydro‐1h‐pyrazol‐1‐yl) quinazolin‐4(3H)‐one 6(a‐d) derivatives, an easy, clean, and economical methodology has been defined. The development of a new pathway for the preparation of substituted derivatives of Quinazoline Pyrazole is highlighted in this report. The mild, inexpensive polyphosphoric acid has proven to be an effective catalyst for excellent yields in the above multi‐component reaction. Widely available and mostly benign catalyst and easy purification are among the several attractive features.

APA, Harvard, Vancouver, ISO, and other styles

23

Selvam, Periyasamy, Paulchamy Vijayalakshimi, Donald F. Smee, et al. "Novel 3-sulphonamido-quinazolin-4(3H)-One Derivatives: Microwave-Assisted Synthesis and Evaluation of Antiviral Activities against Respiratory and Biodefense Viruses." Antiviral Chemistry and Chemotherapy 18, no. 5 (2007): 301–5. http://dx.doi.org/10.1177/095632020701800506.

Full text

Abstract:

We designed and synthesized novel 2,3-disubstituted quinazolin-4(3 H)-ones by microwave technique and characterized them by spectral analysis. Synthesized compounds were screened for cytotoxicity and for antiviral activity against influenza A (H1N1, H3N2 and H5N1), severe acute respiratory syndrome corona, dengue, yellow fever, Venezuelan equine encephalitis (VEE), Rift Valley fever, and Tacaribe viruses in cell culture. A neutral red uptake assay was used to determine 50% virus-inhibitory concentrations (EC50) of test compounds and their 50% cytotoxicity concentration (CC50) in uninfected Mad

APA, Harvard, Vancouver, ISO, and other styles

24

M. Patel, Sejalkumari, Paresh S. Patel, and Keshav C. Patel. "SYNTHESIS AND APPLICATIONS OF SOME REACTIVE DYES HAVING QUINAZOLIN-4(3H)-ONE MOIETY." International Journal of Advanced Research 10, no. 03 (2022): 506–19. http://dx.doi.org/10.21474/ijar01/14412.

Full text

Abstract:

Some reactive dyes (6a-6l) having Quinazolin-4(3H)-one reactive system have been synthesized by coupling of diazotized 3-(4-(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl) phenyl)-4-oxo-2-phenyl-3,4-dihydroquinazoline-6-sulphonic acid with cyanurated coupling components such as H-acid, J-acid, N-methyl J-acid, Gamma acid, Peri acid, Sulpho Tobias acid, Koch acid, Bronners acid, Chicago acid, K-acid, N-Phenyl J-acid and M-acid. The synthesized dyes were characterized by nitrogen elemental analysis, IR, and 1H-NMR spectra. They were applied on wool, silk, and cotton fibres. Their dyeing properties, fas

APA, Harvard, Vancouver, ISO, and other styles

25

Dahikar, Girish D., and Rajendra O. Ganjiwale. "Synthesis and molecular docking of some new quinazoline analogues as anticonvulsants." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 487. https://doi.org/10.59467/ijhc.2025.35.487.

Full text

Abstract:

Two series of new compounds, namely, 6-substituted-2-ethyl-3-(6-substituted-benzothiazol-2-yl)-3H-quinazolin-4-ones (De1-De10) and 6-substituted-2-ethyl-3-(pyridin-4-yl-formamide)-3H-quinazolin-4-ones (Ee1-Ee2) were prepared by condensing 6-substituted-2-ethyl-4-oxo-4H-3,1-benzoxazines (A1-2) with 6-substituted-2-aminobenzothiazoles (B1-5) and hydrazide of isonicotinic acid (C), respectively. The anticonvulsant activity of six derivatives was assessed against the Maximal Electroshock induced convulsions model in albino mice. All compounds were administered by the intraperitoneal route at a dos

APA, Harvard, Vancouver, ISO, and other styles

26

Ukrainets, I. V., S. G. Taran, P. A. Bezuglyi, S. N. Kovalenko, A. V. Turov, and N. A. Marusenko. "4-hydroxy-2-quinolones. 18. Synthesis and antithyroid activity of 1-R-2-oxo-3-(4-oxo-3H-quinazolin-2-yl)-4-hydroxyquinolines." Chemistry of Heterocyclic Compounds 29, no. 9 (1993): 1044–47. http://dx.doi.org/10.1007/bf00534390.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Patel, N. B., F. M. Shaikh, V. N. Patel, H. R. Patel, A. R. Shaikh, and J. N. Patel. "Synthesis and antimicrobial activity of new disubstituted 4-thiazolidinones of diclofenac analogue." International Journal of Drug Design and Discovery 3, no. 4 (2025): 921–29. https://doi.org/10.37285/ijddd.3.4.6.

Full text

Abstract:

In continuation of our work on diclofenac analogues, a new series of (4-oxo-thiazolidinyl) sulphonamides of quinazolin 6a-l was prepared from Schiff bases 5a-l. All the synthesized compounds have been examined by elemental analyses, IR, 1H NMR and 13C NMR spectra and tested for in vitro antibacterial activity against four bacterial and in vitro antifungal activities against three fungal species by broth dilution method. Some of the compounds demonstrated good to remarkable antibacterial as well as antifungal activities. It can be observed that antimicrobial activity gets changed dramatically o

APA, Harvard, Vancouver, ISO, and other styles

28

Sayapin, Yu A., E. A. Gusakov, A. A. Kolodina, et al. "Synthesis and structure of 2-(4′-oxo-3H-quinazolin-2′-yl)-1,3-tropolone." Russian Chemical Bulletin 63, no. 6 (2014): 1364–72. http://dx.doi.org/10.1007/s11172-014-0604-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Amir, Mohammad, and Israr Ali. "Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides." Synthetic Communications 41, no. 14 (2011): 2086–95. http://dx.doi.org/10.1080/00397911.2010.497594.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Zhou, Yuefen, Douglas E. Murphy, Zhongxiang Sun, and Vlad E. Gregor. "Novel parallel synthesis of N-(4-oxo-2-substituted-4H-quinazolin-3-yl)-substituted sulfonamides." Tetrahedron Letters 45, no. 43 (2004): 8049–51. http://dx.doi.org/10.1016/j.tetlet.2004.08.183.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Raval, Jignesh Priyakant, Akhaja T N, Myangar K N, and D. R. Naik. "Synthesis of Novel Azetidinyl-3-(isonicotinamide-yl)-6-iodoquinazolin- 4-ones as Antimicrobial and Antitubercular Agents." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 2 (2012): 1735–44. http://dx.doi.org/10.37285/ijpsn.2012.5.2.9.

Full text

Abstract:

A novel new series of 2-[(4'-oxo-3'-chloro-2'-phenylazetidin-1'-yl)-aminomethyl]-3-[N-isonicotinamide-yl]-6-iodo-quinazolin-4-ones were synthesized using the reaction of chloroacetylchloride and appropriate Schiff base. The synthesized compounds were characterized on the basis of their elemental and spectral analysis (IR, 1H-NMR, 13C-NMR and mass spectrometry). All newly synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv. They were also tested in vitro for antibacterial activity against selected human pathogens such as E. c

APA, Harvard, Vancouver, ISO, and other styles

32

ALAGARSAMY, V., RAMGOPAL APPANI, M. T. SULTHANA, B. NARENDAR, and V. RAJA SOLOMON. "DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF 1-(4-OXO-3-(4-FLUOROPHENYL)-3H-QUINAZOLIN- 2-YL)-4-(SUBSTITUTED) THIOSEMICARBAZIDE DERIVATIVES." Journal of the Chilean Chemical Society 61, no. 2 (2016): 2856–60. http://dx.doi.org/10.4067/s0717-97072016000200002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Lee, Ji Yun, Huarong Yang, Donghwa Kim, et al. "Antiproliferative Activity of a New Quinazolin-4(3H)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer." Pharmaceuticals 15, no. 6 (2022): 698. http://dx.doi.org/10.3390/ph15060698.

Full text

Abstract:

Non-small cell lung cancer (NSCLC) is the most common lung cancer subtype. Although chemotherapy and targeted therapy are used for the treatment of patients with NSCLC, the survival rate remains very low. Recent findings suggested that aurora kinase A (AKA), a cell cycle regulator, is a potential target for NSCLC therapy. Previously, we reported that a chemical entity of quinazolin-4(3H)-one represents a new template for AKA inhibitors, with antiproliferative activity against cancer cells. A quinazolin-4(3H)-one derivative was further designed and synthesized in order to improve the pharmacoki

APA, Harvard, Vancouver, ISO, and other styles

34

Jagani, Chandresh L., Natvar A. Sojitra, Satish F. Vanparia, Tarosh S. Patel, Ritu B. Dixit, and Bharat C. Dixit. "A convergent microwave assisted synthesis of 4-amino-N-(4-oxo-2-substituted-4H-quinazolin-3-yl)benzenesulfonamide derivatives." Arkivoc 2011, no. 9 (2011): 221–37. http://dx.doi.org/10.3998/ark.5550190.0012.916.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Alagarsamy, V., G. V. Anjana, M. T. Sulthana, P. Parthiban, and V. Raja Solomon. "Antimicrobial Activities of Some Synthesized 1-(3-(2-Methylphenyl)-4-Oxo-3H-quinazolin-2-yl-4-(Substituted)thiosemicarbazide Derivatives." Биоорганическая химия 42, no. 3 (2016): 367–74. http://dx.doi.org/10.7868/s0132342316030027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Alagarsamy, V., G. V. Anjana, M. T. Sulthana, P. Parthiban, and V. Raja Solomon. "Antimicrobial activities of some synthesized 1-(3-(2-methylphenyl)-4-Oxo-3H-quinazolin-2-yl-4-(substituted)thiosemicarbazide derivatives." Russian Journal of Bioorganic Chemistry 42, no. 3 (2016): 332–39. http://dx.doi.org/10.1134/s106816201603002x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Alagarsamy, V., B. Arun kumar, P. Parthiban, R. V. Sheorey, and V. Raja Solomon. "Synthesis and Antibacterial Activity of Some Novel 1-(4-Oxo-3-(3- methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides." Anti-Infective Agents 10, no. 2 (2012): 105–10. http://dx.doi.org/10.2174/2211362611208020105.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Amir, Mohammad, and Israr Ali. "ChemInform Abstract: Novel Approach for the Synthesis of N-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides." ChemInform 43, no. 2 (2011): no. http://dx.doi.org/10.1002/chin.201202170.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Parmar, Dharmishtha R., and B. N. Suhagia. "QSAR Study of N-((3-Benzamido-4-oxo-3,4-Dihydroquinazolin 2-yl)methyl)-N-(Substituted) Phenyl Benzamide as Antiulcer Agents." International Journal of Quantitative Structure-Property Relationships 8, no. 1 (2023): 1–14. http://dx.doi.org/10.4018/ijqspr.320179.

Full text

Abstract:

Suppression of gastric acid secretion by use of proton pump inhibitors is an efficient way to control hyperacidity complications. An inhibitory activity of N-((3-Benzamido-4-oxo-3, 4 dihydro quinazolin -2-yl) methyl)-N-(substituted phenyl) benzamides on H+/K+-ATPase was established and reported earlier. Thus, it is significant to develop more promising agents by quantitative structure-activity relationship (QSAR) study of 37 ligands by multi-linear regression method to link the structures of molecules with inhibitory activity on H+/K+-ATPase (pIc50). QSAR model was built using genetic function

APA, Harvard, Vancouver, ISO, and other styles

40

Raghavendra, Nulgulmnalli Manjunathiah, Parameshwaran Thampi, Purvarga Mattada Gurubasavarajaswamy, and Dharmarajan Sriram. "Synthesis and Antimicrobial Activities of Some Novel Substituted 2-Imidazolyl-N-(4-oxo-quinazolin-3(4H)-yl)-acetamides." CHEMICAL & PHARMACEUTICAL BULLETIN 55, no. 11 (2007): 1615–19. http://dx.doi.org/10.1248/cpb.55.1615.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Priteshkumar, Patel, Joshi Hirak, Patel Bhagirath, and Bapna Mayank. "In Silico Study of N-(4-oxo-2-(4-(4-(2-(substituted phenyl amino) acetyl) piperazin-1-yl) phenyl) quinazolin-3(4 H )-yl) Benzamide Derivativ." Pharmacophore 14, no. 2 (2023): 65–70. http://dx.doi.org/10.51847/fjs1ptrlex.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Krolenko, K. Yu, S. V. Vlasov, I. O. Zhuravel, and T. P. Osolodchenko. "The search for new antimicrobial agents from the substituted arylamides of 4-(4-oxo-4H-quinazolin-3-yl)-piperidine-1-carboxylic acids." Journal of Organic and Pharmaceutical Chemistry 14, no. 1(53) (2016): 17–23. http://dx.doi.org/10.24959/ophcj.16.877.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Bozdag, Murat, Ahmed M. Alafeefy, Fabrizio Carta, et al. "Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties." Bioorganic & Medicinal Chemistry 24, no. 18 (2016): 4100–4107. http://dx.doi.org/10.1016/j.bmc.2016.06.052.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Pramilla, Sab, Kachhawaha Vanita, and M. Singhvi P. "1-Aryl substituted-3-(2' -chlorophenyl)-5-(3''-phenyl-4" -oxo-(3" H)-quinazolin-2" -mercaptoacetyl)formazans as insecticidal agents." Journal of Indian Chemical Society Vol. 87, Apr 2010 (2010): 431–35. https://doi.org/10.5281/zenodo.5785202.

Full text

Abstract:

Department of Chemistry, hoepartment of Zoology, J. N. V. University, Jodhpur-342 005, Rajasthan, India <em>Manuscript received 5 September 2007, revised 16 January 2009, accepted 1 September 2009</em> Synthesis of some novel formazans have been carried out by the reaction of 2-mercapto-2-(methylamldo-2'-chloro-<em>N</em>-benzylidene)-3·phenyl-4-oxo·(3<em>H</em>)·quinazoline with diazotised solution of aromatic amines in pyridine and screened for their insecticidal activity against <em>Tribolium confusum</em>.

APA, Harvard, Vancouver, ISO, and other styles

45

Kashaw, Sushil K., Varsha Kashaw, Pradeep Mishra, and N. K. Jain. "Design, synthesis and potential CNS activity of some novel 1-(4-substituted-phenyl)-3-(4-oxo-2-propyl-4H-quinazolin-3-yl)-urea." Arkivoc 2008, no. 14 (2008): 17–26. http://dx.doi.org/10.3998/ark.5550190.0009.e03.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Letourneau, Jeffrey J., Christopher M. Riviello, Hong Li, et al. "Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists." Bioorganic & Medicinal Chemistry Letters 20, no. 18 (2010): 5394–97. http://dx.doi.org/10.1016/j.bmcl.2010.07.118.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Napier, Susan E., Jeffrey J. Letourneau, Nasrin Ansari, et al. "Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists." Bioorganic & Medicinal Chemistry Letters 21, no. 6 (2011): 1871–75. http://dx.doi.org/10.1016/j.bmcl.2010.12.081.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Jain, Rakesh Kumar, and Varsha Kashaw. "Design, synthesis and anticonvulsant activity of some new bioactive 1-(4-substituted-phenyl-3-(4-oxo-2-methyl/phenyl-4H-quinazolin-3-yl)-urea." Asian Journal of Pharmacy and Pharmacology 4, no. 5 (2018): 706–14. http://dx.doi.org/10.31024/ajpp.2018.4.5.25.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Kashaw, Sushil K., Varsha Kashaw, Pradeep Mishra, N. K. Jain, and J. P. Stables. "Design, synthesis, and potential CNS activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-methyl-4H-quinazolin-3-yl)-urea." Medicinal Chemistry Research 20, no. 6 (2010): 738–45. http://dx.doi.org/10.1007/s00044-010-9362-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Lutsenko, Daria N., Eugenia V. Kompantseva, Alexey S. Chiriapkin, et al. "Study of the stability of the biologically active compound N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidine using electrophoresis and mass spectrometry." Сорбционные и хроматографические процессы 24, no. 2 (2024): 257–67. http://dx.doi.org/10.17308/sorpchrom.2024.24/12128.

Full text

Abstract:

At the Scientific Centre of Innovative Medicines of Volgograd State Medical University, a number of pyrimidine derivatives of guanidine were designed and synthesised to study them as promising inhibitors of sodium-hydrogen exchanger isoform 1 (NHE-1), which can reduce tissue damage during ischemia. N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidine (VMA-13-15) proved to be the most pharmacologically valuable compound. When preparing regulatory documentation for a new medicine, one of the quality criteria is the amount of related impurities. They can be technological impurities and degradation

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!