Relevant bibliographies by topics / 4-oxo-quinoline

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Academic literature on the topic '4-oxo-quinoline'

Author: Grafiati
Published: 10 September 2021
Last updated: 29 July 2025

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Journal articles on the topic "4-oxo-quinoline"

1

Horta, Pedro, Marta S. C. Henriques, Elisa M. Brás, et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate." Pure and Applied Chemistry 89, no. 6 (2017): 765–80. http://dx.doi.org/10.1515/pac-2016-1119.

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AbstractRecent studies directed to the design of compounds targeting the bc1 protein complex of Plasmodium falciparum, the parasite responsible for most lethal cases of malaria, identified quinolones (4-oxo-quinolines) with low nanomolar inhibitory activity against both the enzyme and infected erythrocytes. The 4-oxo-quinoline 3-ester chemotype emerged as a possible source of potent bc1 inhibitors, prompting us to expand the library of available analogs for SAR studies and subsequent lead optimization. We now report the synthesis and structural characterization of unexpected ethyl 6-methyl-7-i
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2

Rádl, Stanislav, Viktor Zikán, and František Šmejkal. "Syntheses of some N-carboxymethyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H-(2H)-pyrazolo[3,4-b]quinoline with antiviral effects." Collection of Czechoslovak Chemical Communications 50, no. 9 (1985): 2010–14. http://dx.doi.org/10.1135/cccc19852010.

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The paper describes the syntheses of 4,9-dihydro-9-carboxymethyl-1,3-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ic), 4,9-dihydro-9-carboxymethyl-2,3-dimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (IIc), 4,9-dihydro-1-carboxymethyl-3-methyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Id), 4,9-dihydro-1-carboxymethyl-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (If) and 4,9-dihydro-2-carboxymethyl-3,9-dimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (IIf). The compounds were tested in vivo in mice for their efficacy against the virus A2-Hongkong and the encephalomyocarditis virus.
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Rádl, Stanislav, and Viktor Zikán. "Synthesis and biological activity of some basic-substituted 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinolines." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1812–19. http://dx.doi.org/10.1135/cccc19881812.

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Compounds Ia, Ib were obtained by an alkylation of 4,9-dihydro-6-hydroxy-1,3,9-trimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (VIIb) with the respective dialkylaminoalkyl chloride. The same alkylation of 4,9-dihydro-6-hydroxy-2,3,9-trimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (VIIIb) yielded compounds IIa and IIb. Similar alkylation of 4,9-dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (IXa) and its 6-methoxy derivative (IXb) afforded IIIa-IIId. Compound IV was prepared from 4-chloro-3-methyl-1H-pyrazolo[3,4-b]quinoline (Xa) via its 1-(3-dimethylaminopropyl)derivative (Xb). Compo
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4

Heleyová, Katarína, Dušan Ilavský, Vladimír Bobošík, and Naďa Prónayová. "Gould-Jacobs Reaction of 5- and 6-Amino-2-substituted Benzoxazoles. II. Reaction with 3-Ethoxymethylene-2,4-pentanedione and Ethyl 2-Ethoxymethylene-3-oxobutanoate." Collection of Czechoslovak Chemical Communications 61, no. 3 (1996): 371–80. http://dx.doi.org/10.1135/cccc19960371.

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Nucleophilic reaction of 5-amino- and 6-amino-2-substituted benzoxazoles 1 and 2 with 3-ethoxymethylene-2,4-pentanedione (3) gave compounds 5 and 6. Compounds 1 and 2 reacted with ethyl ethoxymethylene-3-oxobutanoate (4) under formation of compounds 7and 8. The substitution products 7 and 8 underwent thermal cyclization at high temperature (boiling mixture of diphenyl ether and biphenyl) to give angularly and linearly annelated derivatives of 5-acetyl-4-oxo-oxazolo[4,5-f]quinoline 9 and 7-acetyl-8-oxo-oxazolo[5,4-g]quinoline 10 (from 7), and derivatives of 8-acetyl-9-oxo-oxazolo[5,4-f]quinolin
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5

Rádl, Stanislav, and Viktor Zikán. "Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity." Collection of Czechoslovak Chemical Communications 52, no. 3 (1987): 788–92. http://dx.doi.org/10.1135/cccc19870788.

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The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demeth
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6

Radini, Ibrahim Ali, Sameh Ramadan El-Gogary, Mohamed Sabri Mostafa, Bander Alnagei, Mohammed Mudarbish, and Shadad Dash. "Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction." European Journal of Chemistry 9, no. 1 (2018): 44–48. http://dx.doi.org/10.5155/eurjchem.9.1.44-48.1679.

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Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.
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7

Rádl, Stanislav, and Viktor Zikán. "Syntheses of some 4-dialkylaminoalkylamino derivatives of 2,3-dimethyl-2H- and 3,9-dimethyl-9H-pyrazolo[3,4-b]quinoline." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1692–97. http://dx.doi.org/10.1135/cccc19861692.

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Reactions of 4-chloro-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline and 4-chloro-6-methoxy-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline with 3-dimethylaminopropylamine and/or 2-dimethylaminoethylamine afforded 4-(3-dimethylaminopropylamino)-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline (IIa), its 6-methoxy derivative (IIc), 4-(2-diethylaminoethylamino)-2,3-dimethyl-2H-pyrazolo[3,4-b]quinoline (IIb) and its 6-methoxy derivative (IId). Reaction of 4,9-dihydro-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline with thionyl chloride gave an intermediate, whose reaction with 3-dimethylaminopropylamine afforded 4-(3-
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8

V, Sangeetha. "SYNTHESIS OF ISOXAZOLO AND PYRAZOLINO ANNELATED CARBAZOLES FROM 2-(3'-(2'-CHLORO) QUINOLIDINE)-1-OXO-1, 2, 3, 4-TETRAHYDROCARBAZOLE AND 2-CHLORO-3-FORMYLQUINOLINE." Kongunadu Research Journal 2, no. 1 (2015): 29–31. http://dx.doi.org/10.26524/krj61.

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1-Oxo-1,2,3,4-tetrahydrocarbazole (1) on mixed aldol condensation with 2-chloro-3-formylquinoline (2) ielded 2-(3'-(2'-chloro)quinolidine)-1-oxo-1,2,3,4-tetrahydrocarbazole (3), which was further treated with hydroxylamine hydrochloride and hydrazine hydrate in separate reactions to afford 4,5-dihydro-3-3'-(2'-chloro) quinoline -isoxazolo [3,4-a]carbazole (4) and 3'-(2'-chloro)- quinoline- 3,3a,4,5- tetrahydro- 2Hpyrazolino [3,4-a]carbazole (5). The prepared compounds were elaluated for their invitro antibacterial and antifungal activities against certain pathogenic fungal and bacterial strain
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9

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were
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10

Zhang, Jinpeng, Jie Ding, Shu Yan, Liangce Rong, and Lichun Xu. "4-(4-Fluorophenyl)-2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1354. http://dx.doi.org/10.1107/s1600536809017991.

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In the molecule of the title compound, C20H13FN2O, the fluorophenyl ring is oriented at a dihedral angle of 72.76 (3)° with respect to the fused benzene ring. In the crystal structure, intermolecular N—H...O, C—H...O and C—H...F interactions link the molecules into chains. π–π contacts between the quinoline and benzene rings [centroid–centroid distance = 3.918 (3) Å] may further stabilize the structure. A weak C—H...π interaction is also present. The O atom and two of the CH2groups of the quinoline ring system are disordered over two positions. The O atom was refined with occupancies of 0.489
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Dissertations / Theses on the topic "4-oxo-quinoline"

1

Horta, Pedro Filipe Castela. "Design and synthesis of novel quinolones directed to the Plasmodium falciparum bc1 protein complex." Doctoral thesis, 2016. http://hdl.handle.net/10400.1/8685.

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Tese de Doutoramento, Química, Especialização em Química Orgânica, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016<br>Apesar dos intensos esforços para controlo da malária, esta doença parasítica milenar permanece como uma das doenças infeciosas conducentes a maiores taxas de mortalidade no mundo. É transmitida pela picada de um mosquito infectado do género Anopheles (apenas a fémea transmite a doença) e causada por um parasita do género Plasmodium. P. falciparum é a mais prevalente de entre as cinco estirpes de Plasmodium que afectam o homem e é também a mais mortal, sendo r
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Conference papers on the topic "4-oxo-quinoline"

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Matiková Maľarová, Miroslava, Alexandra Bilá, Mária Vilková, Erika Samoľová, Zuzana Jendželovská, and Viktória Buľková. "New vanadium complexes with potential biological activity." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.431mm.

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Two slightly different manner of syntheses lead to the formation of four molecular complexes with two type of coordination arrangement; brown complexes VO(iPrO)(dBrQ)2 (1), VO(iPrO)(5I7BrQ)2 (2) and dark green VO(Cl)(dBrQ)2 (3), VO(iPrO)(5I7BrQ)2 (4). The presence of water and isopropanol in synthesis plays a crucial role in the formation of these two types of complexes. Otherwise also some dinuclear oxo-bridged complexes with four quinoline-8-ol derivatives coordinated to vanadium (V) were obtained in this reactions scheme. The mononuclear complexes were characterized by elemental analysis, i
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