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Journal articles on the topic '4-thiadiazole derivatives'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

A. Ameen, Husam, and Ahlam J. Qasir. "Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 98–104. http://dx.doi.org/10.31351/vol21iss1pp98-104.

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Nitrogen heterocycles are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities.Among these nitrogen heterocycles are 1, 3, 4-thiadiazole containing compounds. The therapeutic effects of these derivatives have been well studied for a number of pathological conditions including inflammation, pain, or hypertension. Moreover, synthesis of thiadiazoles has attracted wide-spread attention due to their diverse applications as antibacterial, anticancer, antifungal anti-inflammatory and antidepressant ag

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2

Singh, S., and Amandeep Kaur. "SYNTHESIS AND ANTICANCER ACTIVITY OF NOVEL 2-BENZYL-6- (SUBSTITUTED PHENYL)-IMIDAZO[2,1-B] [1,3,4] THIADIAZOLE DERIVATIVES." INDIAN DRUGS 56, no. 04 (2019): 13–20. http://dx.doi.org/10.53879/id.56.04.11454.

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A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds were evaluated for their anticancer activity against various cancer cell lines. The anticancer activity data reveals that the compounds S1 (2-benzyl- 6-phenylimidazo[2,1-b][1,3,4]thiadiazole) showed maximum growth inhibition against CNS cancer cell lines while the compounds S2 (2-benzyl-6-(4-chlorophenyl) imidazo[2,1-b][1,3,4] thiadiazole) and S3 (2-benzyl-6-(2,4-dichlorophenyl)imidazo[2,1-b][1,3,4] thiadiazole) showed maximum inhibition ag

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3

Rakhmonov, R., Sh Sharipov, M. Odilzoda, B. Safarov, A. Kobilzoda, and A. Abdurakhmonov. "SYNTHESIS AND FUNCTIONALIZATION OF SOME PARA-R-PHENYLIMIDAZO[2,1-B][1,3,4]- THIADIAZOLE DERIVATIVES." East European Scientific Journal 1, no. 4(68) (2021): 54–61. http://dx.doi.org/10.31618/essa.2782-1994.2021.1.68.15.

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The article describes the synthesis of new modifications of derivatives of 6-phenyl-, 6-piodophenyl- and 6-p-bromophenylimidazo[2,1-b][1,3,4]-thiadiazoles - N -((6-(4-iodophenyl)-2-R-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methyl)-alkyl/ heterylamine based on the Mannich reaction, bromination 2((ethylsulfonyl)methyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole and the structure of the resulting compounds was established on the basis of IR spectroscopy. It was shown that the presence of substituents at the 2-nd position of the thiadiazole fragment and substituents at the 5th and 6th positions of th

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4

Zain Alabdeen, Khalid. "The Activity of 1,3,4 Thiadiazole Derivatives on the Soluble Oils." Journal of Petroleum Research and Studies 2, no. 1 (2021): 59–88. http://dx.doi.org/10.52716/jprs.v2i1.34.

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That Thiadiazoles derivative is biologically active as antimicrobial agents in cooling fluids. Derivatives of 1, 3, 4- thiadiazole have prepared:  2-amino-3-[(2-amino-1, 3, 4-thiadiazol-5-yl) dithio] propanoic acid. 2-(2-Carbethoxyamino-1, 3, 4-thiadiazol-5-yl)-thio acetic acid. [(5-amino-1,3,4-thiadiazol-2-yl) dithio] acetic acid  The synthesized compounds have been used as antimicrobial against the microorganisms which have been found in the cooling fluid of industrial purposes by using media culture the results showed that the compounds 1 and

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5

Zhao, Yuxiang, Peter J. McCarthy, and Cyril Párkányi. "Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring." ISRN Organic Chemistry 2013 (March 5, 2013): 1–10. http://dx.doi.org/10.1155/2013/159164.

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The synthesis of six thiadiazole nucleoside analogs is reported: 5-diacetylamino-1,2,4-thiadiazol-3-one (1), 5-amino-2- (tetrahydrofuran-2-yl)-1,2,4-thiadiazol-3-one (2), 5-amino-3-[(2′-hydroxyethoxy)methyl]-1,3,4-thiadiazol-2-one (3), 5-amino-3-(4′-hydroxy-2′-hydroxymethyl-butyl)-1,3,4-thiadiazole-2-thione (4), (R)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5), and (S)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (6). The synthesis, characterization, and properties of these new synthesized thiadiazole derivatives are discussed. A dimerization of 5-amino-3H-1

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6

Yu, Lu, Lingling Xiao, Pei Li, Jiyan Chi, Jie Li, and Shuming Tan. "Synthesis and Bioactivity Evaluation of Novel Thiochroman-4-One Derivatives Incorporating Carboxamide and 1, 3, 4-Thiadiazole Thioether Moieties." Journal of Chemistry 2022 (February 26, 2022): 1–7. http://dx.doi.org/10.1155/2022/5354088.

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A series of novel thiochroman-4-one derivatives incorporating carboxamide and 1, 3, 4-thiadiazole thioether moieties were synthesized. Bioassay results indicated that the EC50 values of compound 6-chloro-N-(5-(methylthio)-1, 3, 4-thiadiazol-2-yl)-4-oxothiochromane-2-carboxamide (5a) against Xanthomonas oryzae pv. Oryzae (Xoo) and Xanthomonas axonopodis pv. Citri (Xac) were 24 and 30 μg/mL, respectively, which were even better than those of bismerthiazol and thiadiazole copper. Meanwhile, compound 6-methyl-4-oxo-N-(5-(propylthio)-1, 3, 4-thiadiazol-2-yl)thiochromane-2-carboxamide (5m) showed a

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7

Ergena, Asrat, Yerra Rajeshwar, and Gebremedhin Solomon. "Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles." Scientifica 2022 (April 8, 2022): 1–9. http://dx.doi.org/10.1155/2022/3011531.

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1,3,4-Thiadiazole nuclease, a 5-membered heterocyclic ring system containing two nitrogen and one sulfur atoms in addition to carbon atoms, is compound that showed promising results in the process of searching new diuretic agents. In this study, seven 5- and 2-thioate derivatives of 1, 3, 4-thiadiazoles were synthesized by substitution reaction using acetone as solvent and K2CO3 as a base. The compounds ware then characterized by using IR and NMR spectroscopy. The diuretic activity of the compounds was evaluated on Swiss albino mice by measuring urine volume, urinary pH, and urinary Na+, K+, a

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8

Ammar Ferman Abbood. "Synthesis, Characterization and Molecular Docking Study of New 1,3,4-Thiadiazole Derivatives." Journal of Wasit for Science and Medicine 17, no. 3 (2024): 26–38. http://dx.doi.org/10.31185/jwsm.503.

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In this study, a series of 5-(5-{(Z)-[(4-R1)methylidene]amino}-1,3,4-thiadiazol-2-yl)benzene-1,2,3-triol (L1-3), and 4-(5-{(Z)-[(4-R1)methylidene]amino}-1,3,4-thiadiazol-2-yl)benzene-1,2-diol (L4-6) compounds were synthesized, where R1 = 4-Nitro, 4-bromo, 4-chloro. The reaction between benzoic acid derivatives and hydrazinecarbothioamide in the basic medium gave the intended products with high yield and purity. The preparation of the compounds was confirmed by spectroscopic measurements in addition to physical properties. The biological properties of the prepared compounds were studied by mole

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9

JOHNSON, REEJA, JOBY THOMAS KAKKASSERY, Vinod Raphael Palayoor, Ragi Kooliyat, and Vidhya Thomas Kannanaikkal. "Experimental and Theoretical Investigations on the Corrosion Inhibition action of Thiadiazole Derivatives on Carbon Steel in 1M HCl medium." Oriental Journal Of Chemistry 36, no. 6 (2020): 1179–88. http://dx.doi.org/10.13005/ojc/360624.

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Novel thiadiazole derivatives of Schiff bases namely (E)-N-(anthracen-9-ylmethylene)-5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (A9CNPTDA) and N-(anthracen-9(10H)-ylidene)-5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (ANNPTDA) were synthesized, characterized and corrosion inhibition behaviour, as well as the mechanism of inhibition were investigated by different monitoring techniques like gravimetric measurements, electrochemical impedance spectroscopy, potentiodynamic polarization, quantum chemical and SEM studies. Both of the thiadiazole derivatives showed excellent corrosion inhibitor action

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10

Shein, Anatoliy B., Mariya D. Plotnikova, and Alexander E. Rubtsov. "PROTECTIVE PROPERTIES OF SOME THIADIAZOLE DERIVATIVES IN SULFURIC ACID SOLUTIONS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 62, no. 7 (2019): 123–29. http://dx.doi.org/10.6060/ivkkt.20196207.5968.

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The work presents the results of the study of some thiadiazole derivatives as corrosion inhibitors for mild steel in 5-20% H2SO4. Gravimetric tests and electrochemical studies were performed on low-carbon steel St3 at ambient temperature. The exposure time of the samples was 24 h. Polarization curves were obtained by potentiodynamic method (v = 1 mV/s) in a three-electrode cell, using the SOLARTRON 1280 C electrochemical measuring complex. The following thiadiazole derivatives were studied: (E)-N,N-dimethyl-4-{[(5-phenyl-1,3,4-thiadiazol-2-yl)imino]methyl}aniline, (E)-5-{[4-(dimethylamino)benz

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11

Chmovzh, Timofey N., Timofey A. Kudryashev, Daria A. Alekhina, and Oleg A. Rakitin. "Palladium-Catalyzed Direct (Het)arylation Reactions of Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole and 4,8-Dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)." Molecules 28, no. 9 (2023): 3977. http://dx.doi.org/10.3390/molecules28093977.

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Palladium-catalyzed direct (het)arylation reactions of strongly electron-withdrawing tricyclic benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) and its 4,8-dibromo derivative were studied; the conditions for the selective formation of mono- and bis-aryl derivatives were found. The reaction of 4,8-dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) with thiophenes in the presence of palladium acetate as a catalyst and potassium pivalate as a base, depending on the conditions used, selectively gave both mono- and bis-thienylated benzo-bis-thiadiazoles in low to moderate yields; arenes were found to be i

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12

Pavlova, V. V., P. V. Zadorozhnii, V. V. Kiselev, A. V. Kharchenko, and O. V. Okhtina. "Modeling of new potential inhibitors of dihydrofolate reductase based on 1,3,4-thiadiazole amidoalkyl derivatives." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 5 (October 2023): 91–97. http://dx.doi.org/10.32434/0321-4095-2023-150-5-91-97.

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Derivatives of 1,3,4-thiadiazole are very important for medical chemistry and pharmacy as potential drug substances. In this work, we carried out molecular docking studies of amidoalkyl derivatives of 1,3,4-thiadiazole: N-(2,2,2-trichloro-1-((5-aryl-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides and N-(2,2,2-trichloro-1-((5-(arylamino)-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides with dihydrofolate reductase (DHFR). The AutoDock Vina program based on the PyRx 0.8 platform was used for docking. Before docking, the enzyme structure (PDB ID: 1DLS) was prepared using the Chimera 1.14 program, an

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13

Chmovzh, Timofey N., Timofey A. Kudryashev, Karim S. Gaisin, and Oleg A. Rakitin. "Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)-4-carbonitrile." Molbank 2023, no. 3 (2023): M1683. http://dx.doi.org/10.3390/m1683.

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Electron-withdrawing heterocyclic units are found in most organic optoelectronic materials. Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) is an interesting new heterocyclic system, the chemical properties of which are much less studied than other fused thiadiazoles. Cyano derivatives of electron-accepting heterocycles are known as potential components of photoluminescent materials. In this communication, benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)-4-carbonitrile was successfully obtained via the cyanation of 4-bromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) with copper(I) cyanide in DMF. The struc

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14

Kumar, Davinder, Navidha Aggarwal, Virender Kumar, et al. "Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives." Pharmaceuticals 16, no. 4 (2023): 517. http://dx.doi.org/10.3390/ph16040517.

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By exploiting the ample biological potential of 1,3,4-oxadiazole/thiadiazole ring, 4-substitutedphenyl-1,3,4-oxadiazol/Thiadiazol-2-yl)-4-(4-substitutedphenyl) azetidin-2-one derivatives were prepared. Various substituted azetidin-2-one derivatives have been identified as immunostimulating and antimicrobial, as well as their antioxidant activity. 2-amino 1,3,4 oxadiazole/thiadiazole conjugates were synthesized by mixing semi/thio carbazides and sodium acetate with water and stirring well, followed by adding aldehydes in methanol at room temperature. Acetate (glacial) was used as the catalyst t

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15

Chmovzh, Timofey N., Daria A. Alekhina, Timofey A. Kudryashev, Rinat R. Aysin, Alexander A. Korlyukov, and Oleg A. Rakitin. "Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) and Its Bromo Derivatives: Molecular Structure and Reactivity." International Journal of Molecular Sciences 24, no. 10 (2023): 8835. http://dx.doi.org/10.3390/ijms24108835.

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Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) (isoBBT) is a new electron-withdrawing building block that can be used to obtain potentially interesting compounds for the synthesis of OLEDs and organic solar cells components. The electronic structure and delocalization in benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole), 4-bromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole), and 4,8-dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) were studied using X-ray diffraction analysis and ab initio calculations by EDDB and GIMIC methods and were compared to the corresponding properties of benzo[1,2-c:4,5-c′]bis[1,2,

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16

Alazawi, Shaymaa K., and Mohammed Hadi Ali Al-Jumaili. "Novel spiroheterocycles containing a 1,3,4-thiadiazole unit: Synthesis and spectroscopic characterization." Journal of Chemical Research 46, no. 4 (2022): 174751982211095. http://dx.doi.org/10.1177/17475198221109503.

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We describe the preparation of a series of novel spiroheterocycles, namely 1,3,4-thiadiazole derivatives possessing an indane unit. These active heterocyclic compounds are prepared starting from thiocarbohydrazide and 2-indanone via an intermediate indan-2-thiocarbohydrazone which is used to afford the corresponding 2-(1-acetylhydrazino)-4 H-acetyl-5-spiro(indano-2-yl)-1,3,4-thiadiazoline in an acidic medium. The 1,3,4-thiadiazole derivatives are obtained in good yields by reaction with aromatic carboxylic acids at reflux temperature in the presence of POCl3 as a catalyst, their structure–acti

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17

Journal, Baghdad Science. "Synthesis of some Schiff's bases derivatives from aminoazo compounds." Baghdad Science Journal 4, no. 3 (2007): 416–19. http://dx.doi.org/10.21123/bsj.4.3.416-419.

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Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol (S2),5-[{ 4-[(3,4- dimethoxybenzyldene )amino phenyl ] diazenyl)-1,3,4- thiadiazole-2-thiol,(S3) and -5- [4-(1,H – pyrrol -2- yl- methylene)amino phenyl] diazenyl)-1,3,4- thiadiazole-2- thiol (S4) respectively as schiff's bases compounds. On the same route-2-[(4-amino-1- naphthyl ) diazenyl] -1,3,4- thiadiazole -5- thiol (S5) reacts with –p- chlo

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18

K, Vandana, Anoob Kumar K. I, Jisha Prems, Vidhya K. M, and Lal Prasanth M. L. "Characterization & Invitro Antioxidant Activity of 1, 3, 4 Thiadiazole Derivatives of Thiazolidinone." Saudi Journal of Medical and Pharmaceutical Sciences 11, no. 06 (2025): 452–61. https://doi.org/10.36348/sjmps.2025.v11i06.002.

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In view of the considerable importance of thiadiazoles and thiazolidinones, which are the core structures in a variety of pharmaceuticals with a broad spectrum of biological activity. Synthesis of series of potential biological active 1, 3, 4 thiadiazole linked 4 thiazolidinone derivatives were obtained via a multistep synthesis sequence with a simple and convenient approach by using substituted benzoic acids, which are expected to possess enhanced antioxidant activity based on the literature survey reports. In the present study the initial compound, 5-phenyl-1, 3, 4-thiadiazol-2-amine was tre

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19

Journal, Baghdad Science. "Synthesis and Characterization of New Heterocyclic Compounds from 2, 5- dimercapto -1, 3, 4-Thiadiazole and Their Resins." Baghdad Science Journal 13, no. 2 (2016): 275–88. http://dx.doi.org/10.21123/bsj.13.2.275-288.

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In this research, a new 1, 3, 4-Thiadiazole derivatives have been synthesized by many heterocyclic reactions. Starting from (2, 5 – dimercapto -1, 3, 4-Thiadiazole) a variety of derivatives have been synthesis. Compound (1) was synthesized by the reaction of hydrazine hydrate with carbon disulphide in absolute ethanol. The compound (1) was reacted with 1, 2-dibromoethane in presence of alkali ethanol to give the compound (2). The compound (3) was formed from the reaction of compound (2) with hydrazine hydrate. Schiff base (4) was obtained by reacting of compound (3) with the compound (p-hydrox

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20

Shi, Da-Hua, Hui-Long Zhu, Yu-Wei Liu, et al. "Synthesis and Evaluation of 5-Benzyl-1,3,4-Thiadiazole Derivatives as Acetylcholinesterase Inhibitors." Journal of Chemical Research 41, no. 11 (2017): 664–67. http://dx.doi.org/10.3184/174751917x15094552081242.

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Three novel 5-benzyl-1,3,4-thiadiazole derivatives were synthesised starting from phenylacetic acid derivatives. These compounds were characterised by NMR, HRMS and single-crystal X-ray diffraction analysis. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl]-1,3,4-thiadiazole showed moderate acetylcholinesterase-inhibition activity with a 50% inhibitory concentration value of 33.16 μM. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl]-1,3,4-thiadiazole and acetylcholinesterase docking was demonstrated using the Molecular Operating Environment program.

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21

Joseph, Alex, Chaitanyakumar S. Shah, Suthar Sharad Kumar, et al. "Synthesis, in vitro anticancer and antioxidant activity of thiadiazole substituted thiazolidin-4-ones." Acta Pharmaceutica 63, no. 3 (2013): 397–408. http://dx.doi.org/10.2478/acph-2013-0028.

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Abstract A series of novel 5-alkyl/aryl thiadiazole substituted thiazolidin-4-ones were synthesized by a two-step process. In the first step, 5-alkyl/aryl substituted 2-aminothiadiazoles were synthesized, which on reaction with substituted aromatic aldehydes and thioglycolic acid in the presence of dicyclohexylcarbodiimide afforded thiazolidin- 4-ones. All the compounds were synthesized in fairly good yields and their structures were confirmed by spectral and physical data. The title compounds were screened for in vitro anti-proliferative activity on human breast adenocarcinoma cells (MCF-7) b

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22

KOKILA, DESAI, and J. BAXI A. "Studies on 4-Thiazolidinone. Part-VI. Synthesis and Antimicrobial Activity of 5-(2'4'-Dichlorophenoxymethyl)- 2-(2'-aryl-5'(H)-4'-thiazolidinone)-1,3,4-thiadiazole." Journal of Indian Chemical Society Vol. 69, Apr 1992 (1992): 212–14. https://doi.org/10.5281/zenodo.6003245.

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Department o !Chemistry, Saurashtra University, Rajkot-360 005 <em>Manuscript received 11 June 1991, revised 17 March 1992, accepted 23 March 1993</em> Some new 4-thiazolidinone derivatives bearing 1,3,4-thiadiazole moiety have been synthesised by treating thiosemicarbazide with 2 4 dichlorophenoxyacetic acid in presence of phosphorous oxychloride. This on treatment with aromatic aldehydes gave Schiff bases of thiadiazoles which on further reaction with thioglycolic, thiolactic and thiomalic acids yielded the desired products The structures of the compounds have been established by elemental a

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23

Vedika Dadlani, Pushpendra Tripathi, and Rakesh Somani. "Design, Molecular Docking and In-Silico Analysis of Novel thiadiazole-azetidinone hybrids as Potential Antitubercular Agents." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3694–703. http://dx.doi.org/10.26452/ijrps.v10i4.1756.

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The recent emergence of extensively drug-resistant tuberculosis has become a cause of concern for the management of tuberculosis globally. Shikimic acid pathway seems to be a potential and favorable target for the drug design of new anti-infective agents. This work aims to change the focus from traditional cell approaches to the target-based design of novel thiadiazolyl-azetidinone derivatives with Shikimate kinase as the drug target for anti-tubercular activity. Thiadiazole and azetidinone derivatives were methodically reprised to design a series of 3-chloro-4-(aryl)-1-(5-sulfanyl-1,3,4-thiad

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24

Abouzied, Amr S., Jehan Y. Al-Humaidi, Abdulrahman S. Bazaid, et al. "Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety." Molecules 27, no. 19 (2022): 6368. http://dx.doi.org/10.3390/molecules27196368.

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Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea (2) was prepared and reacted with various hydrazonoyl halides 3a–h, α-haloketones 5a–d, 3-chloropentane-2,4-dione 7a and ethyl 2-chloro-3-oxobutanoate 7b, which afforded the 3-aryl-5-substituted 1,3,4-thiadiazoles 4a–h, 3-phenyl-4-arylthiazoles 6a–d and the 4-methyl-3- phenyl

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25

Dróżdż, Agnieszka, Adrianna Sławińska-Brych, Dominika Kubera, et al. "Effect of Antibiotic Amphotericin B Combinations with Selected 1,3,4-Thiadiazole Derivatives on RPTECs in an In Vitro Model." International Journal of Molecular Sciences 23, no. 23 (2022): 15260. http://dx.doi.org/10.3390/ijms232315260.

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4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol (C1) and 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl] benzene1,3-diol (NTBD) are representative derivatives of the thiadiazole group, with a high antimycotic potential and minimal toxicity against normal human fibroblast cells. The present study has proved its ability to synergize with the antifungal activity of AmB. The aim of this work was to evaluate the cytotoxic effects of C1 or NTBD, alone or in combination with AmB, on human renal proximal tubule epithelial cells (RPTECs) in vitro. Cell viability was assessed with the MTT assay

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26

Yadav, M., Sumit Kumar, and Debasis Behera. "Inhibition Effect of Substituted Thiadiazoles on Corrosion Activity of N80 Steel in HCl Solution." Journal of Metallurgy 2013 (April 18, 2013): 1–14. http://dx.doi.org/10.1155/2013/256403.

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The inhibition effect of some prepared compounds, namely, thiadiazole derivatives, on N80 steel corrosion in 15% HCl solutions has been studied by using the weight loss, electrochemical polarization, and electrochemical impedance spectroscopy techniques. It was found that the inhibition efficiency of the thiadiazole derivatives, namely, 2-amino-5-(4-methoxyphenyl)-1,3,4-thiazole (AMPT), 2-amino-5-phenyl-1,3,4-thiazole (APT), and 2-amino-5-(4-chlorophenyl)-1,3,4-thiazole (ACPT), increases with the increase in concentration. Inhibition efficiency follows the order AMPT > APT > ACPT. The ef

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Naik, Ravi S. "Synthesis and Spectral Studies of Hydantoin Derivativatives of Imidazo [2,1-b][1,3,4] Thiadiazoles." International Journal for Research in Applied Science and Engineering Technology 10, no. 2 (2022): 1270–71. http://dx.doi.org/10.22214/ijraset.2022.40510.

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Abstract: The present article describes the synthesis of Imidazo[2,1-b][1,3,4]thiadiazoles bearing pharmacologically important hydantoin molecules. To synthesize the targeted molecules several imidazothiadiazoles were prepared by condensation of 2- Amino-5-(4-fluorobenzyl)-1,3,4thiadiazole with phenacyl bromides. Which were subsequently subjected to Knoevenagel condensation to afford the hydantoin derivatives. Structures of newly synthesized molecules were confirmed by IR, NMR and Mass spectral studies. Keywords: Thiadiazole, Imidazothiadiazole, hydantoin, Vilsmeier Haack reaction

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Shulgau, Zarina, Irina V. Palamarchuk, Shynggys Sergazy, Assel Urazbayeva, Yerlan Ramankulov та Ivan V. Kulakov. "Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of 1,3,4-Thiadiazole Derivatives of 3-Aminopyridin-2(1H)-ones". Pharmaceuticals 17, № 3 (2024): 377. http://dx.doi.org/10.3390/ph17030377.

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This article reports on the synthesis of nine promising new 1,3,4-thiadiazole derivatives based on 3-aminopyridones, containing various acidic linkers. The synthesis was carried out by cyclizing the corresponding thiohydrazides 4a–c and anhydrides of glutaric, maleic, and phthalic acids upon heating in acetic acid solution. The conducted bio-screening of the synthesized new 1,3,4-thiadiazole derivatives containing different acidic linkers (butanoic, acrylic, and benzoic acids) showed that they have significant inhibitory activity against α-glucosidase (up to 95.0%), which is 1.9 times higher t

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Mishra, AD. "A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives." BIBECHANA 8 (January 15, 2012): 17–22. http://dx.doi.org/10.3126/bibechana.v8i0.4766.

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Thiosemicarbazide of 6-chloro-2- aminobenzothiazole on cyclization with different aromatic carboxylic acids in Phosphorus oxychloride provided the corresponding 2-aryl-5-(6’-chloro-1’,3’-benzothiazole-2-yl-amino)-1,3,4-thiadiazoles 4a-j. The compounds are characterized by elemental analysis, IR and 1H NMR spectral data. All the compounds are evaluated in vitro for their antimicrobial activities against several fungal and bacterial strains and showed significant activities.Keywords: Aminobenzothiazole; 1, 3, 4- thiadiazole; antimicrobial; cyclizationDOI: http://dx.doi.org/10.3126/bibechana.v8i0

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NizamMohideen, M., S. Syed Abuthahir, V. Viswanathan, D. Velmurugan, and M. Karthik Ananth. "The crystal structures and Hirshfeld surface analyses of four 3,5-diacetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl derivatives." Acta Crystallographica Section E Crystallographic Communications 75, no. 10 (2019): 1436–44. http://dx.doi.org/10.1107/s2056989019011915.

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The title compounds, 4-(5-acetamido-3-acetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate, C20H19N3O4S (I), 4-(5-acetamido-3-acetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)phenyl isobutyrate 0.25-hydrate, C17H21N3O4S·0.25H2O (II), 4-(5-acetamido-3-acetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)phenyl propionate, C16H19N3O4S (III) and 4-(5-acetamido-3-acetyl-2-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)phenyl cinnamate chloroform hemisolvate, C22H21N3O4S·0.5CHCl3 (IV), all crystallize with two independent molecules (A and B) in the asymmetric unit in the triclinic P\overline{1

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31

Ardan, Bohdan, Vasyl Kinzhybalo, Yurii Slyvka, et al. "Ligand-forced dimerization of copper(I)–olefin complexes bearing a 1,3,4-thiadiazole core." Acta Crystallographica Section C Structural Chemistry 73, no. 1 (2017): 36–46. http://dx.doi.org/10.1107/s2053229616018751.

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As an important class of heterocyclic compounds, 1,3,4-thiadiazoles have a broad range of potential applications in medicine, agriculture and materials chemistry, and were found to be excellent precursors for the crystal engineering of organometallic materials. The coordinating behaviour of allyl derivatives of 1,3,4-thiadiazoles with respect to transition metal ions has been little studied. Five new crystalline copper(I) π-complexes have been obtained by means of an alternating current electrochemical technique and have been characterized by single-crystal X-ray diffraction and IR spectroscop

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32

Rusul Mohammed Hasan Ali and Ayad Al-Hamashi. "Design, Synthesis, and Preliminary Antiproliferative Evaluation of 1,2,4-Thiadiazole Derivatives as Possible Histone Deacetylase Inhibitors." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 57–66. https://doi.org/10.31351/vol33iss(4si)pp57-66.

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Histone deacetylases (HDACs) are a class of proteins that responsible of the hydrolysis of N-acetyl lysine residues in histones as well as non-histone protein substrates. This phenomenon may provide an explanation for the involvement of these enzymes in a wide range of clinical situations, encompassing cancer, metabolic, cardiovascular problems, and neurological diseases. Most of HDAC inhibitors are often used in clinical settings consist of a hydroxamate group (ZBG) that binds to zinc ion inside the active site. The poor selectivity and pharmacokinetic characteristics of numerous medicines be

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Almasirad, Ali, Loghman Firoozpour, Maliheh Nejati, et al. "Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents." Zeitschrift für Naturforschung B 71, no. 3 (2016): 205–10. http://dx.doi.org/10.1515/znb-2015-0138.

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AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

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Hassaneen, Huwaida M. E., and Richard M. Pagni. "Synthesis of New 3-Substituted Indole Derivatives." Zeitschrift für Naturforschung B 65, no. 12 (2010): 1491–97. http://dx.doi.org/10.1515/znb-2010-1213.

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Treatment of 3-cyanoacetyl-2-methylindole (1) with phenyl isothiocyanate gave the corresponding thioacetanilide derivative 3. The thioacetanilide 3 was utilized as the key intermediate for the synthesis of some new 1,3,4-thiadiazole (6a, b and 9a - e), thiophene (11a, b), thiazolidin-4-one (4), thiazole (12 and 13), and benzothiazole (15) derivatives. The structures of the new compounds were elucidated on the basis of elemental analyses and spectral data.

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35

Khan, Yousaf, Aneela Maalik, Wajid Rehman, et al. "Synthesis, in vitro bio-evaluation and in silico molecular docking studies of thiadiazole-based Schiff base derivatives." Future Medicinal Chemistry 16, no. 4 (2024): 335–48. http://dx.doi.org/10.4155/fmc-2023-0276.

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Aim: Recently, thiadiazole-containing drugs have gained greater clinical relevance and are being explored for the development of new antidiabetic, antiurease and antimicrobial agents that target drug resistance. Methods & results: The authors disclose the synthesis of N-(5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl)methanimine derivatives starting from 4-(trifluoromethyl)benzoic acid. All of the synthesized derivatives were evaluated for their biological potential in order to investigate the inhibitory activity against antidiabetic, antiurease and antibacterial profiles. Compounds 1

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36

Kumar, Aadesh, N. A. Farooqui, Nidhi Dhama, and Vikrant Verma. "NOVEL THIADIAZOLE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ITS ANTIBACTERIAL ACTIVITY." Rasayan Journal of Chemistry, Special (2021): 143–49. http://dx.doi.org/10.31788/rjc.2021.1456524.

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A variety of thiadiazole derivatives were synthesized in the laboratory with the aim of new antibacterial drugs development. There is a mounting requirement to manufacture novel antimicrobial drugs attributable to the increasing resistance towards traditional antibiotic drugs. In specific, compounds embodying 1, 3, 4-thiadiazole moiety are acknowledged to possess exceptional antibacterial activities. All the twelve novel thiadiazole synthesized derivatives are tested for their physiochemical properties. They were obtained in good yields and are characterized by different I.R, N.M.R, and Mass t

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Lelyukh, Maryan, Halyna Halevych, Maria Zhukrovska, Olga n. Semiion-Luchyshyn, and Myroslava Kalytovska. "Synthesis of 5-aryl/heterylidene substituted 2-imino-4-thiazolidinones possessing 1,3,4-thiadiazole moiety and their antitrypanosomal activity." Current Chemistry Letters 12, no. 2 (2023): 413–20. http://dx.doi.org/10.5267/j.ccl.2022.11.005.

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A novel 1,3,4-thiadiazole containing 2-iminothiazolidine-4-ones 4a-b were synthesized through the reaction of 2-chloro-N-(5-ethyl/allylsulfanyl-[1,3,4]thiadiazol-2-yl)-acetamides 1a-b with ammonium thiocyanate in dry acetone. Condensation of 4a-b with various carbonyl compounds according to the standard Knoevenagel procedure yielded the corresponding 5-arylidene- (5a-d), 5-heterylidene- (6a-c), 5-isatinylidene- (7a-b) and 5-(3-phenyl-2-propene-1-ylidene)- (8a-b) derivatives. All the newly synthesized compounds were confirmed by their elemental analysis and spectral data. Synthesized compounds

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38

Daniel, K., and V. Daniel. "IN SILICO DOCKING STUDIES, SYNTHESIS AND CHACTERIZATION OF SOME NOVEL 1,3,4 THIADIAZOLE ANALOGUES OF 4-AMINO HIPPURIC ACID AS POTENT ANTIMICROBIAL AGENTS." INDIAN DRUGS 55, no. 12 (2018): 7–17. http://dx.doi.org/10.53879/id.55.12.11551.

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The chemistry of heterocyclic compounds has been an interesting field of study for a long time. The heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behaviour have gained more importance in recent decades. Molecular docking is a key tool in structural molecular biology and CADD. The goal of the ligand protein is to predict the predominant binding model(s) of ligand with a protein of known 3D structure. In the present work, the motto was t

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39

Abu-Hashem, Ameen Ali, and Rasha A. M. Faty. "Synthesis, Antimicrobial Evaluation of Some New 1, 3, 4-Thiadiazoles and 1, 3, 4- Thiadiazines." Current Organic Synthesis 15, no. 8 (2018): 1161–70. http://dx.doi.org/10.2174/1570179415666180720114547.

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Background: 1, 3, 4-thiadiazoles, 1, 3, 4-thiadiazines and thienopyrimidines have newly attracted attention due to their forceful pharmacological activities. They showed antimicrobial, antiviral, analgesic and anti-inflammatory properties. Objective: The aim of this research is to synthesize new thiadiazolothienopyrimidines (2-10), thienopyrimidothiadiazines (11-15), quinoxaline-thienopyrimidinones (16) and thienopyrimido- thiadiazinoquinoxalinones (17) via effectual high yield procedure for assessing their antimicrobial activity. Method: A series of new 1, 3, 4-thiadiazolothienopyrimidines, t

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40

Aggarwal, Navidha, and Sandeep Jain. "A Synthetic Approach, Characterization and Biological Evaluation of Novel 5-(Arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one Derivatives." Asian Journal of Chemistry 33, no. 7 (2021): 1530–36. http://dx.doi.org/10.14233/ajchem.2021.23203.

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The extensive biological potential of thiazolidin-4-one and 1,3,4-thiadiazole moieties, the novel string of 5-(arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one has been synthesized and characterized. The synthesized derivatives were screened for antimicrobial potential using serial tube dilution method. The results showed that all the synthesized compounds have significant biological activity against the microorganisms being tested. The antimicrobial activity of the compounds TA2, TA3, TA4, TA9, TA10 and TA20 against the tested microbial strains was promising. Compound TA4 (

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41

Vedekhina, T. S., M. V. Chudinov, and A. Yu Lukin. "Design and synthesis of 4-nitroimidazole derivatives with potential antitubercular activity." Fine Chemical Technologies 18, no. 3 (2023): 219–29. http://dx.doi.org/10.32362/2410-6593-2023-18-3-219-229.

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Objectives. To develop the procedures for synthesis of hybrid molecules with potential anti-tubercular activity containing heterocyclic cores of 4-nitroimidazole and 1,3,4-thiadiazole within the framework of a double-drug strategy and predict bioactivity of target structures and drug-likeness physicochemical parameters.Methods. Target compounds were prepared by classical organic synthesis methods. The structure of the obtained compounds was characterized by melting points, 1H and 13C nuclear magnetic resonance spectroscopy, and high-resolution mass spectrometry. The calculation of the physicoc

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42

Moskvina, Viktoria, Olexander Turov, Tetyana Shokol, and Volodymyr Khilya. "Synthesis and NMR spectroscopy investigations of functionalized spiropyranochromenediones and their spirothiadiazole derivatives." Ukrainica Bioorganica Acta 16, no. 2 (2021): 18–22. http://dx.doi.org/10.15407/bioorganica2021.02.018.

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This investigation focuses on the synthesis of spiropyranoneoflavones and the modification of obtained compounds at the exocyclic oxygen atom. Kabbe cyclization of 6-acetyl-7‑hydroxy-8-methyl-4-phenyl-2H-chromene-2-one with cyclohexanone or cyclopentanone in the presence of pyrrolidine provided 10-methyl-4-phenyl-2H-spiro[cyclohexane(cyclopentane)-1’,8-pyrano[3,2-g]chromene]-2,6(7H)-diones. Their new functionalized derivatives with thiosemicarbazide residues were synthesized. Acetylation of obtained thiosemicarbazones with acetic anhydride proceeded via cyclization of thiosemicarbazide fragmen

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43

Susumu, Kimihiro, and Michael J. Therien. "Design of diethynyl porphyrin derivatives with high near infrared fluorescence quantum yields." Journal of Porphyrins and Phthalocyanines 19, no. 01-03 (2015): 205–18. http://dx.doi.org/10.1142/s1088424614501107.

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A design strategy for (porphinato)zinc-based fluorophores that possess large near infrared fluorescence quantum yields is described. These fluorophores are based on a (5,15-diethynylporphinato)zinc(II) framework and feature symmetric donor or acceptor units appended at the meso-ethynyl positions via benzo[c][1,2,5]thiadiazole moieties. These (5,15-bis(benzo[c][1′,2′,5′]thiadiazol-4′-ylethynyl)-10,20-bis[2′,6′-bis(3″,3″-dimethyl-1″-butyloxy)phenyl]porphinato)zinc(II) (4), (5,15-bis[4′-(N,N-dihexylamino) benzo[c][1′,2′,5′]thiadiazol-7′-ylethynyl]-10,20-bis[2′,6′-bis(3″,3″-dimethyl-1″-butyloxy)ph

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44

Marupati, Siddhartha, Susmitha Kasula, B. Satheesh, Srinivasa Reddy Bireddy, and Laxminarayana Eppakayala. "Development of an efficient protocol for the synthesis and molecular docking studies of Pyrimidine containing 1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazol‐3‐yl) thio)‐1‐phenylethanone derivatives as promising anticancer agents." Vietnam Journal of Chemistry 60, no. 2 (2022): 169–82. http://dx.doi.org/10.1002/vjch.202100102.

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AbstractPyrimidine containing 1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazol‐3‐yl)thio)‐1‐phenylethanone derivatives shows superior biological activity. In this view, we synthesized a combination of Pyrimidine and triazolo thiadiazole. The target compounds (4a‐o) were synthesized using 5‐methylpyrimidine‐2‐carboxylic acid (1), 4‐amino‐4H‐1,2,4‐triazole‐3,5‐dithiol (2) as starting materials. The prepared compounds were analyzed by spectral analysis and docking studies were carried out into the active site of enzyme dihydrofolate reductase (DHFR), [PDB ID: 3NU0]) using Flare GUI software. The docking ou

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45

Al-Smaisim, Rafah F., Redha E. Al-Bayati, and Abdul Hussain K. Sharba. "Synthesis of New Heterocyclic compounds derived from Pyrazoline-5-one compound." Al Mustansiriyah Journal of Pharmaceutical Sciences 9, no. 1 (2011): 123–31. http://dx.doi.org/10.32947/ajps.v9i1.278.

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In this work new heterocyclic pyrazolin derivatives have been synthesized from diazonium chloride salt of 4-aminobenzoic acid: firstly, Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, (ethyl acetoacetate)obtain the corresponding hydrazono derivative (1). Secondly, Cyclocondensation reaction of compound (1) with hydrazine hydrate (2) in boiling ethanol affording the corresponding pyrazoline-5-one. Then compound (2) reacted with thionyl chloride to give the corresponding acid chloride derivative(3

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46

Kaya, Betül, Ulviye Acar Çevik, Bilge Çiftci, Mesut Isık, Zafer Asım Kaplancıklı, and Şükrü Beydemir. "Design, Synthesis and Cholinesterase Inhibitory Activity of Novel 1,3,4-Thiadiazole Derivatives." Cumhuriyet Science Journal 45, no. 3 (2024): 503–9. http://dx.doi.org/10.17776/csj.1449622.

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Inhibition of the cholinesterases (AChE and BChE) plays a pivotal role in the symptomatic treatment of Alzheimer’s disease. The present study reports the synthesis and anticholinesterase activity of five novel thiadiazole analogs in search of anti-Alzheimer agents. The structures of the newly synthesized compounds were characterized using 1H NMR, 13C NMR and HRMS. Tested compounds inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes with IC50 values in the range of 8.250-20.382 μM and 14.143-0.986 μM, respectively. N-(4-Chlorophenyl)-2-[(5-(allylamino)-1,3,4-thiadiazo

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47

Sivakumar, D., and G. Geetha. "MOLECULAR DOCKING STUDIES ON THIADIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 12 (2018): 70. http://dx.doi.org/10.22159/ijpps.2018v10i12.28948.

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Objective: In the present study, a novel series of 1, 3, 4-thiadiazole derivatives were docked against the mycobacterium tuberculosis protein kinase G. 1, 3, 4–thiadiazole derivatives with a modified primary amine group at 5th position were used for docking studies.Methods: The three-dimensional structure of the protein was obtained from PDB, and its active sites were predicted. The structures of all the compounds were drawn using chemdraw software version 8.0. The docking studies were done by using schrödinger software against the enzyme protein kinase G. Totally eighteen compounds was synthe

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48

Makwane, Sunil, SD Srivastava, Rajiv Dua, and SK Srivastava. "Synthesis and Antimicrobial Activity of 4-Oxo-Thiazolidines and 5-Arylidene Derivatives of 2-Amino-5-Ethyl-1,3,4-Thiadiazole." Journal of Bangladesh Academy of Sciences 42, no. 2 (2018): 155–70. http://dx.doi.org/10.3329/jbas.v42i2.40042.

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A new series of 5-benzylidene-3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-2-phenyl-thiazolidin-4-ones (3a-3m) were synthesized. The reaction of thioglycolic acid with benzylidene-(5-ethyl-[1,3,4] thiadiazol-2-yl)-amine 1a in the presence of anhydrous ZnCl2 afforded the new heterocyclic compounds 5-benzylidene-3-(5-ethyl-[1,3,4] thiadiazole-yl)-2-phenyl-thiazolidin-4-one, 2a. The latter product on treatment with several selected substituted aromatic aldehydes in the presence of sodium ethoxide underwent the Knoevenagel reaction to yield 5-benzylidene-3-(5-ethyl-[1,3,4] thiadiazol-2-yl)-2-phenyl-thiazoli

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49

Caram, José Alberto, María Virginia Mirífico, Silvia Lucía Aimone, and Enrique Julio Vasini. "3,4-Disubstituted derivatives of 1,2,5-thiadiazole 1,1-dioxide. Ethanol addition reactions and electroreduction of 3-methyl-4-phenyl and 3,4-dimethyl derivatives in acetonitrile and ethanol solvents." Canadian Journal of Chemistry 74, no. 8 (1996): 1564–71. http://dx.doi.org/10.1139/v96-173.

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3-Methyl-4-phenyl-1,2,5-thiadiazole 1,1-dioxide (TMP), as well as 3,4-dimethyl-1,2,5-thiadiazole 1,1-dioxide (TMM), react with ethanol (EtOH), which adds to one of their C = N double bonds. The equilibrium constants for the addition reaction are measured in mixed acetonitrile (ACN) – EtOH solvents by means of UV spectroscopy in the case of TMP, and by 13C NMR spectroscopy in the case of TMM, since TMM presents only terminal UV absorption. Both equilibrium constants are also estimated through cyclic voltammetry (CV) experiments. In the case of TMP, the ethanol molecule adds to the C = N bond lo

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Journal, Baghdad Science. "Synthesis, Characterization and Biological Activates Studies of some New Derivatives From 2-aminoo-5-mercapto-1, 3, 4-thiadiazole." Baghdad Science Journal 15, no. 1 (2018): 48–56. http://dx.doi.org/10.21123/bsj.15.1.48-56.

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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1, 3, 4-thiadiazole) as a starting material base. The main heterocyclic compounds (1, 3, 4-thiadiazole, oxazole) etc, 2-amino-5-mercapto-1,3,4-thiadiazole compound (1) was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of (1) via hydrogen peroxide, to have (2) which was treated with chloro acetyl chloride to get (3). Preparation of thiazole ring (4) was from reacting of (3) with thiourea. Synthesis of diazonium

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