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Journal articles on the topic '4-Thiadiazoles[3'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Zakaria, Medhat Mahamed. "Important of Azoles." American International Journal of Biology and Life Sciences 1, no. 1 (2019): 6–14. http://dx.doi.org/10.46545/aijbls.v1i1.30.

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Azoles are one of a cyclic derivatives of chemical heterocyclic chemical and organic compounds including g a five member di unsaturated ring structure composed of bi nitrogen atoms at position (3 and 4) and one sulfur atom at position (1).            Most of prepared work on the four thiadiazoles has been on the 1, 3, 4-thiadiazoles. Physical, theoretical, and spectroscopic properties have been reviewed .

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2

Kong, Yung Cheol, and Kyongtae Kim. "Exploratory chemistry of 3-aroylformamido-4-aryl-1,2,5-thiadiazoles." Journal of Heterocyclic Chemistry 36, no. 2 (1999): 515–23. http://dx.doi.org/10.1002/jhet.5570360231.

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3

Cowden, WB, SJ Sullivan, and DJ Brown. "Unfused Heterobicycles as Amplifiers of Phleomycin. VII> Some Bithiazoles; Thienyl-, Furanyl- and Thiazolyl-thiadiazoles and Related Oxadiazoles." Australian Journal of Chemistry 38, no. 8 (1985): 1257. http://dx.doi.org/10.1071/ch9851257.

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Syntheses are described for several unfused heterobicycles including 4,5′- and 2,4′-bithiazoles, 5-(thiazol-4′ and 5′-yl)-1,3,4- thiadiazoles , 5-(thien-2′-yl)-, 5-(furan-2′ and 3′-yl)-, thiadiazoles and related oxadiazoles, all with side chains containing dialkylamine terminal groups. The activities of these compounds as amplifiers of phleomycin -G are reported.

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4

Abu-Hashem, Ameen Ali, and Rasha A. M. Faty. "Synthesis, Antimicrobial Evaluation of Some New 1, 3, 4-Thiadiazoles and 1, 3, 4- Thiadiazines." Current Organic Synthesis 15, no. 8 (2018): 1161–70. http://dx.doi.org/10.2174/1570179415666180720114547.

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Background: 1, 3, 4-thiadiazoles, 1, 3, 4-thiadiazines and thienopyrimidines have newly attracted attention due to their forceful pharmacological activities. They showed antimicrobial, antiviral, analgesic and anti-inflammatory properties. Objective: The aim of this research is to synthesize new thiadiazolothienopyrimidines (2-10), thienopyrimidothiadiazines (11-15), quinoxaline-thienopyrimidinones (16) and thienopyrimido- thiadiazinoquinoxalinones (17) via effectual high yield procedure for assessing their antimicrobial activity. Method: A series of new 1, 3, 4-thiadiazolothienopyrimidines, t

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5

Ergena, Asrat, Yerra Rajeshwar, and Gebremedhin Solomon. "Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles." Scientifica 2022 (April 8, 2022): 1–9. http://dx.doi.org/10.1155/2022/3011531.

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1,3,4-Thiadiazole nuclease, a 5-membered heterocyclic ring system containing two nitrogen and one sulfur atoms in addition to carbon atoms, is compound that showed promising results in the process of searching new diuretic agents. In this study, seven 5- and 2-thioate derivatives of 1, 3, 4-thiadiazoles were synthesized by substitution reaction using acetone as solvent and K2CO3 as a base. The compounds ware then characterized by using IR and NMR spectroscopy. The diuretic activity of the compounds was evaluated on Swiss albino mice by measuring urine volume, urinary pH, and urinary Na+, K+, a

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6

Мирко, І. І., Ю. І. Горак, Т. І. Чабан, І. В. Драпак, and В. С. Матійчук. "Synthesis and antitumor properties of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles." Farmatsevtychnyi zhurnal, no. 5 (October 22, 2021): 37–49. http://dx.doi.org/10.32352/0367-3057.5.21.04.

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One of the promising methods of creating antitumor drugs is the screening of potential antitumor agents among synthesized compounds. Nitrogen-based heterocycle analogues are an extremely important class of organic substances that are widely used in medical chemistry. [1,2,4]Triazolo[3,4-b][1,3,4] thiadiazoles are among the little-studied and hard-to-reach members of this class of compounds. The aim of our work was to synthesize some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, as well as the study of their antitumor activity. The objects of study were 3-R-

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7

JAG, MOHAN, S. R. ANJANBYULU G., and KIRAN. "Heterocyclic Systems containing Bridgehead Nitrogen Atom. Synthesis of Thiadiazolo[2',3', : 2,1 )imidazo[ 4,5-b)quinoxaline, Jmidazo[2,1-b ]-1,3,4-thiadiazoles and their Brominated Products." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 118–19. https://doi.org/10.5281/zenodo.6303535.

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Department of Chemistry, Maharshi Dayanand University, Rohtak-124 001 <em>Manuscript received 25 March 1988, accepted 2 November 1988</em> 2-Amino-5-alkylthiadiazoles (1) condense with \(\propto\)-haloketones and 2,3-dichloroquinoxalene to furnish respectively the cyclised products, 2,6-disubstituted imidazo [2,1-b]-1,3,4-thiadiazoles (2) and 2-substituted-thiadiazolo(2<em>',</em>3<em>'</em>: 2,1] imidazo[4,5-b]- quinoxaline (4). Bromination of 2 furnishes 5-bromo-2,6-disubstituted-imidazo[2,1-b]- thiadiazoles (3). The antimicrobial activities of some of the compounds have be

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8

Joshi, K. A., J. M. Dhalani, H. B. Bhatt, and K. M. Kapadiya. "Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study." Current Chemistry Letters 10, no. 4 (2021): 479–88. http://dx.doi.org/10.5267/j.ccl.2021.4.003.

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New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in

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9

Smicius, Romualdas, Virginija Jakubkiene, Milda M. Burbuliene, Aiste Mikalainyte, and Povilas Vainilavicius. "Synthesis of 1-(6-Methyl-2,4-Dioxo-1,2,3,4-Tetrahydro-3-Pyrimidinyl)Acetyl-4-Alkyl(Aryl)Thiosemicarbazides and their Heterocyclisation to 1,2,4-Triazoles and 1,3,4-Thiadiazoles." Journal of Chemical Research 2002, no. 4 (2002): 170–72. http://dx.doi.org/10.3184/030823402103171555.

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5-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)methyl-1,3,4-oxadiazole-2-thione reacts with amines to give 1-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetyl-4-alkyl(aryl)thiosemicarbazides, which on treatment with base or acid undergo cyclisation to 4-alkyl-1,2,4-triazole-2-thiones or 4-amino-1,3,4-thiadiazoles, respectively.

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10

Lelyukh, Maryan I., Ivan O. Krukovskiy, Zoryana M. Komarenska, Nataliia V. Yelahina, Taras I. Chaban, and Ihor G. Chaban. "Appliance Features of 4-Amino-1,2,4-triazole-3-thiols in the Synthesis of 3,6-Disubstituted [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles." Acta Chimica Slovenica 72, no. 2 (2025): 238–59. https://doi.org/10.17344/acsi.2025.9169.

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4-Amino-5-substituted-4H-1,2,4-triazole-3-thiols are versatile synthons for the construction of various biologically active heterocycles. This is provided by the close proximity of the amino and mercapto groups, which serve as readily accessible nucleophilic centers for the preparation of N-bridged heterosystems. One of the possible and convenient directions of using 4-amino-4H-1,2,4-triazole-3-thiols in heterocyclic synthesis is based on their utilization in reaction with various carboxylic acids in the presence of dehydrating reagents, most often phosphorus oxychloride. Synthesized as follow

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11

Mekheimer, Ramadan A., and Rafat M. Shaker. "Synthesis and Reactivity of 3-Alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles." Journal of Chemical Research 23, no. 2 (1999): 76–77. http://dx.doi.org/10.1177/174751989902300205.

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Phenyl isothiocyanate reacts with 2-cyanoacetohydrazide (1) to yield the corresponding 1-cyanoacetyl-4-phenylthiosemicarbazide (3), via acid hydrolysis of the intermediate 2 whereas cyclization of 3 gave the 1,2,4-triazoles 4, 1,3,4-thiadiazoles 7 and 1,3,4-thiadiazine-5-ones 9; compound 4a was reacted with phenyl isothiocyanate, dicyandiamide, sulfanylacetic acid and benzaldehyde to afford 11, 13, 14 and 15, respectively.

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12

Kryshenko, F. I., E. A. Knyazeva, L. S. Konstantinova, and O. A. Rakitin. "Synthesis of 4-substituted 3-chloro-1,2,5-thiadiazoles from monosubstituted glyoximes." Russian Chemical Bulletin 65, no. 11 (2016): 2678–81. http://dx.doi.org/10.1007/s11172-016-1635-1.

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13

Kong, Yung Cheol, and Kyongtae Kim. "ChemInform Abstract: Exploratory Chemistry of 3-Aroylformamido-4-aryl-1,2,5-thiadiazoles." ChemInform 30, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199937133.

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14

(Miss), NIRUPAMA TIWARI, and NIZAMUDDIN. "Synthesis of some 2-Aryl-3-(2-imino-4-thiazolidinon-3-yl)-thiazolidin-4-ones, 2-Aryl-3-(2-thiohydantoin-3-yl)- thiazolidin-4-ones and 2-Amino-4-arylthiazolo- [ 4,3-b ]-1, 3,4-thiadiazoles as Possible Bactericides." Journal of Indian Chemical Society Vol. 68, Mar 1991 (1991): 144–46. https://doi.org/10.5281/zenodo.5955479.

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Department of Chemistry, University of Gorakhpur, Gorakhpur-273 009 <em>Manuscript received 13 February 1990, revised 19 October 1990, accepted 7 March 1991</em> 2 Aryl-3-(2-imino-4 thiazolidinon-3-yl)thiazolidin 4 ones (2a —g), 2 aryl-3-(2- thiohydantoin 3-yl)thiazolidin-4-ones (3a — g) and 2-amino 4- arylthiazolo [4,3-<em> b</em>]-1 3,4- thiadiazoles (4a —g) have been obtained by cyclisation of 2-aryl 3 thiocarbanilido-4- thiazolidinones (I) with chloroacetic acid in methanol, pyridine and concentrated sulphuric acid respectively All the compounds have been assayed for thei

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15

JAG, MOHAN, S. R. ANJANEYULU G., and V. S. YAMINI K. "Heterocyclic Systems containing Bridgehead Nitrogen Atom : Synthesis and Antimicrobial Activity of s-Triazolo[3,4-b][1,3,4]thiadiazoles, s-Triazolo[3',4'-b] [1,3.4]thiadiazines and s-Triazolo[3',4' : 2,3][1,3,4]thiadiazino[5,6-b]quinoxaline." Journal of Indian Chemical Society Vol. 68, Aug 1991 (1991): 474–76. https://doi.org/10.5281/zenodo.6197084.

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Department of Chemistry, Mabarshi Dayanand University, Rohtak-124 001 <em>Manuscript received 11 June 1990, revised 12 December 1990, accepted 5 August 1991</em> Heterocyclic Systems containing Bridgehead Nitrogen Atom : Synthesis and Antimicrobial Activity of s-Triazolo[3,4-b][1,3,4]thiadiazoles, s-Triazolo[3',4'-b] [1,3.4]thiadiazines and s-Triazolo[3',4' : 2,3][1,3,4]thiadiazino[5,6-b]quinoxaline.

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16

S., D. Srivastava, and Guru Niharika. "Synthesis and antimicrobial activities of some new pyrazolothiadiazoles and their azetidinones." Journal of Indian Chemical Society Vol. 77, Aug 2000 (2000): 400–401. https://doi.org/10.5281/zenodo.5869215.

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Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, India <em>Manuscript received 4 November 1999, revised 27 March 2000, accepted 17 April 2000</em> Several 2-arylideneamino-5-(<em>N<sup>1</sup></em>-pyrazolomethyl)-1,3,4-thiadiazoles (4) and 1-[5' -(N1-pyrazolomethyl)-1' ,3',4' -thiadiazol-2'-yl]-4-substituted-3-chloro-2-azetidinones (5) have been synthesised and tested for their antibacterial and antifungal activities.

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17

Shailendra, Tiwari, and Nizamuddin. "Synthesis and fungicidal activities of some 2-substituted arylamino-5-(2' -furyl)- 1,3,4-thiadiazolo[3,2-c]thiazoles and 5-substituted aryl-2-substituted arylamino-1 ,3 ,4-thiadiazolo [3 ,2-c ]thiazoles." Journal of Indian Chemical Society Vol. 90, May 2013 (2013): 679–83. https://doi.org/10.5281/zenodo.5772308.

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Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India <em>E-mail</em> : drshailendratiwariau@gmail. com Department of Chemistry, DDU Gorakhpur University, Gorakhpur-273 009, Uttar Pradesh, India <em>E-mail</em> : prnukhan@gmail.com <em>Manuscript received 13 December 2011, revised 14 May 2012, accepted 11 July 2012</em> Several 2-substituted arylamino-5-(2<em>'</em>-furyl)-1,3,4-thiadiazolo[3,2-c]thiazoles have been synthesised by cyclisation of 3-substituted aryl thiocarbanilido-2-(2<em>'</em> -furyl)thiazolidin-4-ones with conc. H<sub>2</sub>SO<sub

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18

Srivastava, Kamna, and S. N. Pandeya. "Synthesis and anticonvulsant activity of 3-arylamino-4-aryl-5-(N-4-chlorophenylthiocarbamido)-1,2,4-thiadiazoles." Bioorganic & Medicinal Chemistry Letters 3, no. 4 (1993): 547–52. http://dx.doi.org/10.1016/s0960-894x(01)81225-7.

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19

Pradeep, Mishra, Jatav Varsha, and K. Kashaw S. "Some novel 2-methyl-3-(1'3' 4' -thiadiazoyl)-4-(3H)quinazolinones with anticonvulsant and CNS depressant activity." Journal of Indian Chemical Society Vol. 83, Nov 2006 (2006): 1165–70. https://doi.org/10.5281/zenodo.5832993.

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Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India E-mail : pmishra51 @rediffmail.com Fax : 91-07582-264236 <em>Manuscript received 4 January 2006, revised 19 June 2006, accepted 23 August 2006</em> A series comprising six novel 2-methyl-3-(1'3'4'-thiadiazoyi)-4(3<em>H</em>)quinazolinones have been synthesized by conden sing different 2-amino-1,3,4-thiadiazoles with 2-methyl benzoxazin-2-one and evaluated for anticonvulsant and CNS depressant activity. Compound Sf exhibited both anticonvulsant an

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20

Kholodniak, О. V., Yu V. Shubina, and S. I. Kovalenko. "Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity." Current issues in pharmacy and medicine: science and practice 15, no. 1 (2022): 5–12. http://dx.doi.org/10.14739/2409-2932.2022.1.252037.

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Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity. Among the significant number of azoles, 1,3,4-thiadiazoles and 1,2,4-triazoles attract special attention, among which are known drugs, larvicides, insecticides, growth regulators, etc. Even though heterocyclizations of functionally substituted hydrazines for their synthesis are well studied, N-(R-hydrazine-1-carbonothioyl)cycloalkanecarboxamides, and nowadays, remain reagents with undiscovered potential. Moreover, the introd

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21

Fizer, Maksym, Mikhailo Slivka, Vjacheslav Baumer, and Vasil Lendel. "Synthesis of 3-alkyl-5-allylamino-2-benzoylimino-1,3,4-thiadiazoles via Dimroth rearrangement." Heterocyclic Communications 22, no. 2 (2016): 79–83. http://dx.doi.org/10.1515/hc-2015-0279.

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AbstractA facile access to 3-alkyl-5-N-allylamino-2-N′-benzoylimino-1,3,4-thiadiazoles via Dimroth rearrangement is reported. Alkylation of 5-allylamino-4-benzoyl-1,2,4-triazole-3-thione with alkyl halides in basic alcohol solution is regioselective. A mechanism for the formation of a 1,3,4-thiadiazole ring by 1,2,4-triazole recyclization is proposed. The obtained compounds were characterized by NMR, elemental analysis and X-ray diffraction analysis.

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22

Fares, Fares A., Damon D. Ridley, and Ping Yin. "Sulfonamide Analogues of Creatinine. The Synthesis of 3-Amino-4,5-dihydro-1,2,4-thiadiazole 1,1-Dioxides from Base-Induced Cyclization Reactions." Australian Journal of Chemistry 50, no. 10 (1997): 1027. http://dx.doi.org/10.1071/c97159.

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We report the preparation of 3-amino-4,5-dihydro-1,2,4-thiadiazole 1,1-dioxide and of its 4-methyl derivative which are of interest as potential analogues of creatinine. The thiadiazoles are obtained from chloromethylsulfonylation ofS-benzylisothiourea, followed by cyclization of the chloromethanesulfonamide under basic conditions in the presence of 2-(t-butoxycarbonyloxyimino)-2-phenylacetonitrile or of methyl iodide.

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23

Merschaert, Alain, and Hugo J. Gorissen. "The Palladium-catalyzed Cross-Coupling Reactions of 3-Chloro-4-halogeno-1,2,5-thiadiazoles." HETEROCYCLES 60, no. 1 (2003): 29. http://dx.doi.org/10.3987/com-02-9550.

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24

Andosova, G. V., V. N. Konyukhov, N. I. Andronova, V. I. Il'enko, L. V. Korobchenko, and E. I. Boreko. "Synthesis of 2,5-substituted 1,3,4-thiadiazoles from 3-phenyl-5-methyl-4-isoxazolylhydrazide." Pharmaceutical Chemistry Journal 21, no. 2 (1987): 124–25. http://dx.doi.org/10.1007/bf00765111.

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25

Mishra, AD. "A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives." BIBECHANA 8 (January 15, 2012): 17–22. http://dx.doi.org/10.3126/bibechana.v8i0.4766.

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Thiosemicarbazide of 6-chloro-2- aminobenzothiazole on cyclization with different aromatic carboxylic acids in Phosphorus oxychloride provided the corresponding 2-aryl-5-(6’-chloro-1’,3’-benzothiazole-2-yl-amino)-1,3,4-thiadiazoles 4a-j. The compounds are characterized by elemental analysis, IR and 1H NMR spectral data. All the compounds are evaluated in vitro for their antimicrobial activities against several fungal and bacterial strains and showed significant activities.Keywords: Aminobenzothiazole; 1, 3, 4- thiadiazole; antimicrobial; cyclizationDOI: http://dx.doi.org/10.3126/bibechana.v8i0

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26

Krishnapriya, K. G., and K. N. Rajasekharan. "Solid state synthesis of 5-anilino-3-(3, 5-dimethylpyrazol-1-yl)-1, 2, 4-thiadiazoles." Bulletin of Pure & Applied Sciences- Chemistry 37c, no. 1 (2018): 12. http://dx.doi.org/10.5958/2320-320x.2018.00003.1.

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27

C., P. JOSHUA, and ANNIE VARGHESE. "Reaction of 1-Aryl- , 1,3 -Diaryl- and 1-Alkyl-3-aryl -S-alkyl- isothioureas with 4-Alkyl/Aryl Thiosemicarbazides : Formation of 4-Alkyl/Aryl-3-arylamino - 5 - mercapto-1,2,4-triazoles and 2, 5-Diarylamino - 1,3,4-thiadiazoles." Journal of Indian Chemical Society Vol. 67, Sep 1990 (1990): 759–63. https://doi.org/10.5281/zenodo.6244765.

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Department of Chemistry, University of Kerala, Trivandrum-695 034 <em>Manuscript received 6 February 1990, revised 30 April 1990, accepted 19 June 1990</em> The interaction of 1-aryl-, 1,3-diaryl- and 1-alkyl-3-aryil-<em>S</em>-alkylisothioureas (1) with 4-alkyl/aryl thiosemicarbazides (2) has been found to afford 4-alkyl/aryl-3- arylamino-5-mercapto-1,2,4-triazoles (5) in good yield. 2,5-Diarylamino-1,3,4-thiadiazoles (6) is also formed as a minor product. A probable mechanism is suggested for the formation of these products.

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28

Rajeswar Rao, V., M. S. Rao, and T. V. Padmanabha Rao. "A novel synthesis of thiazolyl, imidazothiadiazolyl, and thiadiazinyl-2H-1-benzopyran-2-ones." Collection of Czechoslovak Chemical Communications 51, no. 10 (1986): 2214–21. http://dx.doi.org/10.1135/cccc19862214.

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3-Acetylcoumarins I with arylthiourea in the presence of iodine gave substituted 3-(2-arylamino-4-thiazolyl)-2H-1-benzopyran-2-ones (IIa-IIc). The structures of these products have been confirmed and they were converted into acetyl derivatives (IId-IIf). Condensation of various 3-(2-bromoacetyl)-2H-1-benzopyran-2-ones (III) with 2-amino-6-substituted thiadiazoles IV in the presence of ethanol and dimethylformamide yielded substituted 3-(2-substituted imidazo[2,1-b]thiadiazol-6-yl)-2H-1-benzopyran-2-ones (VI). Reaction of III with 3-substituted 4-amino-5-mercapto-S-triazole VII resulted in the

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29

Hovsepyan, T. R., S. V. Dilanyan, N. S. Minasyan, and R. G. Melik-Ohanjanyan. "Synthesis and reactions of new 4-methoxybenzyland 3-chloro-4-methoxybenzyl-substituted 1,2,4-triazoles and 1,3,4-thiadiazoles." Russian Journal of Organic Chemistry 50, no. 5 (2014): 736–41. http://dx.doi.org/10.1134/s1070428014050194.

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30

B., SHIVARAMA HOLLA, K. SHIVANANDA M., and M. AKBERALI P. "Mass Spectral Fragmentation Patterns of Some 4-[5-Aryl-2-furfurylidene]-3- mercapto-5-substituted-1,2,4-triazoles and 6-(5-Aryl-2-furyl)-1 ,2,4-triazolo[3,4-b ]- 1 ,3,4-thiadiazoles." Journal of Indian Chemical Society Vol. 75, Aug 1998 (1998): 465–66. https://doi.org/10.5281/zenodo.5927655.

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Department of Chemistry, Mangalore University, Mangalagangothri-574 199 plama Laboratories Ltd., 120 A/B Industrial Area, Baikampady, New Mangalore-575 011 <em>Manuscript received 4 March 1997, revised 21 November 1997, accepted 24 February 1998</em> Several4-(5-aryl-2-furfurylidene)amino-3-mercapto-5-substituted-1,2,4-triazoles (I) have been synthesized and converted into 6-(5- aryl-2-furyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (2).

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31

Hanold, Norbert, Helga Kalbitz, Mousa Al-Smadi, and Herbert Meier. "1,2,3-Thiadiazole mit ungesättigten Seitenketten - Monomerbausteine für Photoresist-Materialien / 1,2,3-Thiadiazoles with Unsaturated Side Chains - Monomeric Building Blocks for Photoresists." Zeitschrift für Naturforschung B 50, no. 7 (1995): 1121–26. http://dx.doi.org/10.1515/znb-1995-0725.

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The phosphonium salts 4 are versatile reagents for the synthesis of 1,2,3-thiadiazoles 6 with unsaturated side chains. The preparation starts with the α-chloroketones 1 which are transformed in a stepwise process to the phosphonium salts 2 and 3. The reaction with SOCl2 leads to a regioselective ring closure 3 → 4 . Subsequent Wittig reactions yield the monomers 6, which exhibit with the exception of 6ac a high tendency for a thermal polymerization. Cleavage of the ester groups in 6ca and 6 cd generates the carboxylic acids 7ca and 7 cd which possess a higher stability.

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Sarafroz, Mohammad, Yasmin Khatoon, Niyaz Ahmad, Mohammad Amir, Salahuddin Salahuddin, and Faheem Hyder Pottoo. "Synthesis, Characterization and Anticonvulsant Activity of Novel Fused 1,2,4-Triazolo-1,3,4-Thiadiazoles." Oriental Journal of Chemistry 35, no. 1 (2019): 64–70. http://dx.doi.org/10.13005/ojc/350107.

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A novel category of 1,2,4-triazolo-1,3,4-thiadiazoles were ready by the utilization of 3-amino-4-hydroxybenzoate as the beginning material. Spectral information results were used for the establishing of prepared compounds. Compounds were screened anticonvulsant activity for obtaining better results by MES test and scPTZ methods. The rotarod method was used for neurotoxicity analysis. Majority of the compounds displayed distinguished anticonvulsant impact practically identical to standard drugs (phenytoin and carbamazepine) with slight neurotoxicity.

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B., SHIVARAMA HOLLA, and MOHAMMED AKBERALI P. "Studies on Arylfuran Heterocycles. Part-I. Synthesis of 6-( 5-Aryl-2-furyl)-1 ,2,4-triazolo[3,4-b]-1 ,3,4-thiadiazoles." Journal of Indian Chemical Society Vol. 68, Jun 1991 (1991): 341–43. https://doi.org/10.5281/zenodo.5993309.

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Department of Post-Graduate Studies and Research in Chemistry, Mangalore University. Mangalagangothri-574 199 <em>Manuscript received 5 October 1990, revised 5 February 1991, accepted 31 May 1991</em> Several 4-(5-aryl-1-furfurylidene )amino 3-mercapto-5-substituted-1,2, 4-triazoles have been synthesised and converted into 1,24-triazolo[3,4-<em>b</em>]-1,3,4-thiadiazoles. These triazolothiadiazoles are also synthuised by an alternative method in better yields employing arylfuroic acids and <em>s</em>-triazoles in the presence of phosphorus Oxychloride. The compounds are also tested for their a

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34

Bhandari, Namratha, and Santosh L. Gaonkar. "Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones." International Scholarly Research Notices 2014 (November 20, 2014): 1–7. http://dx.doi.org/10.1155/2014/439243.

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The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1H NMR, 13C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by 1H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral

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Sarragiotto, Maria, George Brand, Carla Gomes, Willian Costa, Mary Foglio та Ana Ruiz. "Synthesis and Antitumor Activity of Novel 1-Substituted 3-(4,5-Substituted 1,2,4-Triazol-3-yl)-β-carboline Derivatives". Synthesis 51, № 02 (2018): 573–77. http://dx.doi.org/10.1055/s-0037-1610291.

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Schiff bases, 1,2,4-triazolo[4,3-d][1,2,3,4]thiatriazoles, and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles carrying the β-carboline nucleus were synthesized from 3-(4-amino-5-mercapto-1,2,4-triazol-3-yl)-β-carbolines. The compounds were evaluated for their in vitro antitumor activity against eight human cancer cell lines. The 1,2,4-triazolo[4,3-d][1,2,3,4]thiatriazole derivatives showed a broad spectrum of antitumor activity, with GI50 values lower than 13 μM for all cell lines tested. In general, all tested compounds showed potent activity against the breast (MCF-7) cancer cell line, with GI50 v

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Mobinikhaledi, Akbar, Naser Foroughifar, and Mahsa Bayat. "Synthesis of Some Novel 3-(4-Pyridinyl)-6-aryl- 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles." Organic Preparations and Procedures International 43, no. 4 (2011): 368–71. http://dx.doi.org/10.1080/00304948.2011.582011.

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37

Ivashchenko, A. V., O. S. Petrova, and V. V. Titov. "5-Arylazoimidazo[2, I-b]-1, 3, 4-Thiadiazoles—New Dichroic T-Dyes For LCD." Molecular Crystals and Liquid Crystals 145, no. 1 (1987): 25–29. http://dx.doi.org/10.1080/00268948708080211.

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CHARANJIT, SINGH ANDOTRA, C. LANGER T., and KUMAR SHARMA SHIV. "Synthesis of some Nitro-substituted 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and I ,2,4-Triazoles as Antiamebic Agents." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 122–23. https://doi.org/10.5281/zenodo.5995426.

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Post-Graduate Department of Chemistry, University of Jammu, Jammu-180 004 <em>Manuscript received 20 May 1987, revised 15 November 1988, accepted 14 December 1988</em> <strong>Some 2-(β-arylethyl)-5-phenyiamino-1,3,4-oxadiazoles, 2-(β-arylethyl)-5-phenyiamino-1,3,4-thiadiazoles and 3-(β-arylethyl)-4-phenyl-5-mercapto-1,2,4-triazoles have been synthesised through thiosemicarbazides. All these compounds have been tested in vitro for their amoebicidal activity against <em>E. histolytica</em></strong>

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39

CHARANJIT, SINGH ANDOTRA, C. LANGER T., and KUMAR SHARMA SHIV. "Synthesis of some Nitro-substituted 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles as Antiamebic Agents." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 122–23. https://doi.org/10.5281/zenodo.6303597.

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Post-Graduate Department of Chemistry, University of Jammu, Jammu-180 004 <em>Manuscript received 20 May 1987, revised 15  November 1988, accepted 14 December 1988</em> Some 2-(\(\beta\)-arylethyl)-5-phenylamino-1,3,4-oxadiazoles, 2-(\(\beta\)-arylethyl)-5-phenylamino-1,3,4-thiadiazoles aad 3-(\(\beta\)-arylethyl)-4-phenyl-5-mercapto-1,2,4-triazoles have been synthesised through thiosemicarbazides. All these compounds have been tested in vitro for their amoebicidal activity against \(\mathit{E}\) <em>histolytica</em>.

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40

Khan, Mahmood-ul-Hassan, Tashfeen Akhtar, Khawaja A. Yasin, Najim A. Al-Masoudi, Peter G. G. Jones, and Shahid Hameed. "Synthesis, Crystal Structure and Antiproliferative Activity of 6-Adamantyl-3-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles." Zeitschrift für Naturforschung B 65, no. 2 (2010): 178–84. http://dx.doi.org/10.1515/znb-2010-0214.

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A series of 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a - l bearing an adamantyl moiety were synthesized by condensation of 4-amino-5-aryl-2H-1,2,4-triazole-3(4H)-thiones 4a -l with adamantyl-1-carboxylic acid in the presence of POCl3. The structures of the newly synthesized compounds were established using spectroanalytical techniques and verified further by the crystal structure determination of compounds 5a and 5j. The compounds were screened for their antiproliferative activity against a large panel of human cell lines.

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41

Fallon, Gary D., Craig L. Francis, Katarina Johansson, Andris J. Liepa, and Ruth C. J. Woodgate. "N,N-Dialkyl-N´-Chlorosulfonylchloroformamidines in Heterocyclic Synthesis. II. Thiazolo-, Thiadiazolo-, and Oxadiazolo-Fused [1,2,4,6]Thiatriazine Dioxides." Australian Journal of Chemistry 58, no. 12 (2005): 891. http://dx.doi.org/10.1071/ch05070.

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N,N-dialkyl-N′-chlorosulfonylchloroformamidines 1 were treated with 2-aminothiazoline, 2-aminothiazoles, 2-aminobenzothiazoles, 2-amino-1,3,4-thiadiazoles, and 2-amino-1,3,4-oxadiazoles to give a 6,7-dihydrothiazolo[3,2-b][1,2,4,6]thiatriazine dioxide 3, a 6,7-dihydrothiazolo[2,3-c][1,2,4,6]thiatriazine dioxide 4, thiazolo[3,2-b][1,2,4,6]thiatriazine dioxides 5, [1,2,4,6]thiatriazino[3,2-b]benzothiazole dioxides 7, a [1,2,4,6]thiatriazino[3,4-b]benzothiazole dioxide 8, [1,3,4]thiadiazolo[2,3-c][1,2,4,6]thiatriazine dioxides 10, [1,3,4]thiadiazolo[3,2-b][1,2,4,6]thiatriazine dioxides 11, [1,3,4

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42

C., S. ANDOTRA, C. LANGER T., and KOTHA AMRITA. "Synthesis and Antifungal Activity of some Substituted 1,3,4-Thiadiazolo[3,2-a]-s-triazin-5-phenyl-7-thiones and Imidazo-[2, 1-b ]-1,3,4-thiadiazol-5-ones." Journal of Indian Chemical Society Vol. 74, Feb 1997 (1997): 125–27. https://doi.org/10.5281/zenodo.5875250.

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Department of Chemistry. University of Jammu, Jammu-180 004 <em>Manuscript received 25 October !994. revised 4 July 1995, accepted 4 August 1995</em> 2-Amino-5-aryl-substituted-1,3,4-thiadiazoles (1) have been refluxed with benzoyllsothiocyanate to get N-[5-aryl-substituted-1,3,4- thiadiazol-2-yl)-<em>N</em>-benzoyl thlonreas (1a). These on refluxing with PCI<sub>5</sub> and POCI<sub>3</sub> give 2-aryl-substituted-1,3,4-thiadiazolo[3,2-<em>a</em>]-<em>s</em>- triazin-5-phenyl-7-thiones (3). Compound 1 on refluxing with chloroacetic acid and anhydrous sodium acetate gives 2-substitut

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43

Jadhav, SA, ST Dengle, SR Vaidya, and HB Nagre. "Microwave Assisted Anhydride Catalyzed by Synthesis of 2-Amino-5-Aryl-1,3,4-Thiadiazoles." Chemistry Research Journal 1, no. 4 (2016): 65–70. https://doi.org/10.5281/zenodo.13973168.

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Cyclization of Thiosemicarbazide with substituted aromatic aldehyde over the hazardous reagent and catalyst for the synthesis of 2-amino, 5-aryl-1,3,4-thiadiazoles under microwave irradiation conditions. Screened a sample of a molecule under the conventional and microwave method. The expeditious reaction with good to excellent yield was obtained under the Microwave irradiation method. The synthesized compounds were characterized by IR, <sup>1</sup>H NMR and <sup>13</sup>C NMR analysis.

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44

P., S. FBRNANDBS, and M. SONAR T. "Synthesis and Biological Activity of Heterocyclic Derivatives derived from Ethyl-2-hydroxyquinoxaline-3-carboxylate." Journal of Indian Chemical Society Vol. 63, Apr 1986 (1986): 427–29. https://doi.org/10.5281/zenodo.6273852.

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Nadkarny-Sacasd Research Laboratories, St. Xavier's College, Mahapalika Marg, Bombay-400 001 <em>Manuscript received 15 July 1985, accepted 17 February 1986</em> Ethyl-2-chloroquinoxaline-3-carboxylate obtained from ethyl-2-hydroxyquinoxaline-3-carboxylate upon treatment with morpholine gave ethyl-2-morpholinoquinoxaline-3-carboxylate (1). This ester upon reaction with hydrazine hydrate (99%) gave respective carboxy hydrazide (2). This hydrazide on reaction with phenyl isothiocyanates gave thiosemicarbazides (3a-c). The thiosemicarbazides on reaction with concentrated sulphu

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45

M.D., JOSHI, K. JANI M., R. SHAH B., K. UNDAVIA N., and B. TRIVEDI P. "Synthesis of some Bis-thiosemicarbazones and their related 1,3,4-Thiadiazolines." Journal of Indian Chemical Society Vol. 68, Feb 1991 (1991): 107–8. https://doi.org/10.5281/zenodo.6134694.

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University Department of Chemistry. Bhavnagar University. Bhavnagar-364 002 <em>Manuscript received 3 Jul-y 1990, revised 31 December 1990, accepted 16 January 1991</em> THIOSEMICARBAZIDE detivatives are well-known for their biological activities<sup>1</sup>. Many thiadiazoles also possess antibacterial and antitubercular activities<sup>2</sup>. Some patented materials derive from methylenedianiline (MDA) are active insecticidal and fungicidal agents<sup>3</sup>. MDA ltself is also active antibacterial agents<sup>4</sup>. Keeping this in view, the titled comp

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46

Cho, Jaeeock, and Kyongtae Kim. "Reactions of tetrasulfur tetranitride with alkyl aryl ketoximes: synthesis of 3-aryl- and 3-alkyl-4-aryl-1,2,5-thiadiazoles." Journal of the Chemical Society, Perkin Transactions 1, no. 19 (1993): 2345. http://dx.doi.org/10.1039/p19930002345.

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47

Fedotov, S. O., A. S. Hotsulia, and O. I. Panasenko. "Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles." Current issues in pharmacy and medicine: science and practice 15, no. 2 (2022): 117–22. http://dx.doi.org/10.14739/2409-2932.2022.2.259227.

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Pyrazole and 1,2,4-triazole derivatives play an important strategic role in modern medicine and pharmacy. This fact is due to the significant possibilities of chemical modification and significant pharmacological potential among the derivatives of these heterocycles. The introduction of 1,2,4-triazole and pyrazole fragments into the structure of new substances allows to influence the formation of a certain type of activity. The structural combination of these heterocycles in one molecule increases the likelihood of interaction with various biological targets. At the same time, the creation of

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48

A. Ameen, Husam, and Ahlam J. Qasir. "Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 98–104. http://dx.doi.org/10.31351/vol21iss1pp98-104.

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Nitrogen heterocycles are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities.Among these nitrogen heterocycles are 1, 3, 4-thiadiazole containing compounds. The therapeutic effects of these derivatives have been well studied for a number of pathological conditions including inflammation, pain, or hypertension. Moreover, synthesis of thiadiazoles has attracted wide-spread attention due to their diverse applications as antibacterial, anticancer, antifungal anti-inflammatory and antidepressant ag

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Suresh, Ajay, Dhananjay Dey, Anila M Menon, and Deepak Chopra. "Structural investigation and Hirshfeld surface analysis of two polymorphs of 2-(4-Methylbenzamido)-5-(4-fluoro-3-phenoxyphenyl)-1,3,4-thiadiazoles." Journal of the Indian Chemical Society 99, no. 3 (2022): 100374. http://dx.doi.org/10.1016/j.jics.2022.100374.

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50

Dong, Heng-Shan, Kun Wei, Qing-Lian Wang, Bin Quan, and Zi-Yi Zhang. "Synthesis of 3-[5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-yl]-6-substituted-s-triazolo[3,4-b]-1,3,4-thiadiazoles." Journal of the Chinese Chemical Society 47, no. 2 (2000): 343–46. http://dx.doi.org/10.1002/jccs.200000044.

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