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Journal articles on the topic '4-thiouracile'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Hützler, Wilhelm Maximilian, Ernst Egert, and Michael Bolte. "6-Propyl-2-thiouracilversus6-methoxymethyl-2-thiouracil: enhancing the hydrogen-bonded synthon motif by replacement of a methylene group with an O atom." Acta Crystallographica Section C Structural Chemistry 72, no. 8 (2016): 634–46. http://dx.doi.org/10.1107/s2053229616011281.

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The understanding of intermolecular interactions is a key objective of crystal engineering in order to exploit the derived knowledge for the rational design of new molecular solids with tailored physical and chemical properties. The tools and theories of crystal engineering are indispensable for the rational design of (pharmaceutical) cocrystals. The results of cocrystallization experiments of the antithyroid drug 6-propyl-2-thiouracil (PTU) with 2,4-diaminopyrimidine (DAPY), and of 6-methoxymethyl-2-thiouracil (MOMTU) with DAPY and 2,4,6-triaminopyrimidine (TAPY), respectively, are reported.

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2

Hützler, Wilhelm Maximilian, and Ernst Egert. "Cocrystals of 6-methyl-2-thiouracil: presence of the acceptor–donor–acceptor/donor–acceptor–donor synthon." Acta Crystallographica Section C Structural Chemistry 71, no. 3 (2015): 229–38. http://dx.doi.org/10.1107/s2053229615002867.

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The results of seven cocrystallization experiments of the antithyroid drug 6-methyl-2-thiouracil (MTU), C5H6N2OS, with 2,4-diaminopyrimidine, 2,4,6-triaminopyrimidine and 6-amino-3H-isocytosine (viz.2,6-diamino-3H-pyrimidin-4-one) are reported. MTU features anADA(A= acceptor andD= donor) hydrogen-bonding site, while the three coformers show complementaryDADhydrogen-bonding sites and therefore should be capable of forming anADA/DADN—H...O/N—H...N/N—H...S synthon with MTU. The experiments yielded one cocrystal and six cocrystal solvates, namely 6-methyl-2-thiouracil–2,4-diaminopyrimidine–1-methy

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3

Khvorostov, Artem, Leszek Lapinski, Hanna Rostkowska, and Maciej J. Nowak. "Unimolecular Photochemistry of 4-Thiouracils." Photochemistry and Photobiology 81, no. 5 (2005): 1205. http://dx.doi.org/10.1562/2005-05-19-ra-534.

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4

Ruckenbauer, Matthias, Sebastian Mai, Philipp Marquetand, and Leticia González. "Photoelectron spectra of 2-thiouracil, 4-thiouracil, and 2,4-dithiouracil." Journal of Chemical Physics 144, no. 7 (2016): 074303. http://dx.doi.org/10.1063/1.4941948.

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5

Giuliano, Barbara M., Vitaliy Feyer, Kevin C. Prince, et al. "Tautomerism in 4-Hydroxypyrimidine,S-Methyl-2-thiouracil, and 2-Thiouracil." Journal of Physical Chemistry A 114, no. 48 (2010): 12725–30. http://dx.doi.org/10.1021/jp106883s.

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6

Mohamed, Mosaad, Samir Awad, and Naglaa Ahmed. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica 61, no. 2 (2011): 171–85. http://dx.doi.org/10.2478/v10007-011-0019-1.

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Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivativesA series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-dto10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropy

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7

Giuliano, Barbara M., Vitaliy Feyer, Kevin C. Prince, et al. "Correction to “Tautomerism in 4-Hydroxypyrimidine,S-Methyl-2-thiouracil, and 2-Thiouracil”." Journal of Physical Chemistry A 115, no. 28 (2011): 8178–79. http://dx.doi.org/10.1021/jp204996u.

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8

Šála, Michal, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Pyrimidine C-Nucleoside Analogues." Collection of Czechoslovak Chemical Communications 69, no. 4 (2004): 918–32. http://dx.doi.org/10.1135/cccc20040918.

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The oxirane ring opening of 3-[(benzyloxy)methyl]-7-oxabicyclo[4.1.0]heptane with sodium salt of diethyl malonate followed by treatment with TsOH gave (3aR*,6R*,7aS*)-6-[(benzyloxy)methyl]hexahydro-1-benzofuran-2(3H)-one (3a) and (3aR*,5R*,7aS*)-5-[(benzyloxy)methyl]hexahydro-1-benzofuran-2(3H)-one (3b). Lactones 3a and 3b were formylated and then treated with thiourea or guanidine to give, after deprotection, racemic 5-[2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexyl]-2-thiouracil (5a and 5b) or -isocytosine (12a and 12b). Simple transformations of the 2-thiouracil derivative led to ur

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9

Sarzyńska, J., and T. Kuliński. "Parametrization of 2-thiouracil and 4-thiouracil in CHARMM all-atom empirical force field." Computational Methods in Science and Technology 11, no. 1 (2005): 49–55. http://dx.doi.org/10.12921/cmst.2005.11.01.49-55.

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10

Youssif, Shaker, and Fatmah Agili. "One-pot Synthesis of Fused 2-Thiouracils: Pyrimidopyrimidines, Pyridopyrimidines and Imidazolopyrimidines." Zeitschrift für Naturforschung B 63, no. 7 (2008): 860–64. http://dx.doi.org/10.1515/znb-2008-0709.

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Several 6-substitued-1-methyl-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidine-4-ones and ethyl 7-amino-5-aryl-1-methyl-4-oxo-1,2,3,4-tetrahydro-2-thiopyrido[2,3-d]pyrimidines-6-carboxylates were synthesized by treatment of 6-amino-1-methyl-2-thiouracil with primary amines and formalin (40%), and with ethyl 3-aryl-2-cyanoacrylate respectively. 8-Substituted-7-hydroxy-3- methyl-2-thioxanthines were synthesized by the treatment of 6-amino-1-methyl-5-nitroso-2-thiouracil with benzylidene-anilines. Elemental and spectral analyses were performed for the new compounds.

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11

Hronowski, Lucjan J. J., and Walter A. Szarek. "Synthesis of cyclopentane analogs of (2′- and 3′-deoxy-erythro-pentofuranosyl and ribofuranosyl)-2-thiouracil nucleosides." Canadian Journal of Chemistry 64, no. 8 (1986): 1620–29. http://dx.doi.org/10.1139/v86-268.

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Three new carbocyclic analogs of nucleosides having the 2-thiouracil base have been synthesized. The cyclopentyl groups in these nucleosides are (±)-{(1β,3α,4β)-3-hydroxy-4-(hydroxyrnethyl)cyclopentyl} (see 31), (±)-{(1β,2α,4β)-2-hydroxy-4-(hydroxymethyl)cyclopentyl} (see 32), and (±)-{(1β,2α,3α,4β)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl} (see 33). The nucleosides were prepared by coupling the appropriate hydroxy derivatives of cis-3-aminocyclopentanemethanol with 3-ethoxypropenoyl isothiocyanate (21) followed by cyclization in 15 N aqueous ammonia to give the 2-thiouracil nucleosides. In

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12

Hřebabecký, Hubert, та Antonín Holý. "Synthesis of 1-(3-Azido-2,3-dideoxy-β-D-ribo-hexofuranosyl)-, 1-(2,3-Dideoxy-β-D-erythro-hexofuranosyl)- and 1-(2,3-Dideoxy-β-D-erythro-hex-2-enofuranosyl)pyrimidine Nucleosides". Collection of Czechoslovak Chemical Communications 59, № 2 (1994): 412–20. http://dx.doi.org/10.1135/cccc19940412.

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1-(3-Azido-2,3-dideoxy-β-D-ribo-hexofuranosyl)uracil (XXII) and 1-(2,3-dideoxy-β-D-erythro-hex-2-enofuranosyl)uracil (VIII) were prepared starting from 1-(2-O-acetyl-3,5,6-tri-O-benzoyl-β-D-glucofuranosyl)uracil (I) by a procedure described previously for thymine analogs. 1-(2,3-Dideoxy-β-D-erythro-hexofuranosyl)uracil (XIII) was obtained by catalytic hydrogenation of 1-(5,6-di-O-benzoyl-2,3-dideoxy-β-D-erythro-hex-2-enofuranosyl)uracil (VII) and subsequent methanolysis. Reaction of dibenzoyl derivative VII, 1-(5,6-di-O-benzoyl-2,3-dideoxy-β-D-erythro-hexofuranosyl)uracil (XII) and the diaceta

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13

Qi, Qige, Chunfan Yang, Ye Xia, Kunhui Liu, and Hongmei Su. "Photo-induced Electron Transfer between 4-Thiouracil and Tryptophan." Acta Chimica Sinica 77, no. 6 (2019): 515. http://dx.doi.org/10.6023/a19040149.

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14

Youssif, Shaker, Said El-Bahaie, and Esam Nabih. "A Facile One-pot Synthesis of Pyrido[2,3-d]-pyrimidines and Pyrido[2,3-d:6,5-d‘]dipyrimidines." Journal of Chemical Research 23, no. 2 (1999): 112–13. http://dx.doi.org/10.1177/174751989902300223.

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The reactions of enaminones (6-aminouracils) 1a–c and 4 with cyano olefins 2a–b and 5a–f led to the formation of pyrido[2,3- d]pyrimidines. 3a–f and 6a–f in good yield, while the treatment of 4-amino-2-thiouracil 4 with aromatic aldehydes afforded pyridodipyrimidines 7a–c.

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15

Les, Andrzej, and Ludwik Adamowicz. "Tautomerism of 2- and 4-thiouracil. Ab initio theoretical study." Journal of the American Chemical Society 112, no. 4 (1990): 1504–9. http://dx.doi.org/10.1021/ja00160a032.

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16

Sidhoum, Madjid Ait, Laurent El Kaïm, and Laurence Grimaud. "4-Aminopyrimidine libraries from the Ugi-Smiles reaction of thiouracil." Tetrahedron 74, no. 38 (2018): 5222–31. http://dx.doi.org/10.1016/j.tet.2018.04.058.

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17

Fourrey, Jean-Louis, Jeannette Gasche, Catherine Fontaine, Eric Guittet, and Alain Favre. "Sequence dependent photochemistry of di(deoxynucleoside) phosphates containing 4-thiouracil." Journal of the Chemical Society, Chemical Communications, no. 18 (1989): 1334. http://dx.doi.org/10.1039/c39890001334.

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18

Dzurilla, Milan, Peter Kutschy, and Dušan Koščík. "A new method for preparation of 1-(4-substituted phenyl)-6-phenyl-2-thiouracils via cyclization of N-(4-substituted phenyl)-N'-3-phenylpropenoylthioureas and Dimroth rearrangement of 2-(4-substituted phenylimino)-6-phenyl-5,6-dihydro-4H-1,3-thiazin-4-ones." Collection of Czechoslovak Chemical Communications 52, no. 9 (1987): 2260–65. http://dx.doi.org/10.1135/cccc19872260.

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N-(4-Substituted phenyl)-N'-3-phenylpropenoylthioureas treated with lithium hydride afforded 1-(4-substituted phenyl)-6-phenyl-2-thiouracils; these could also be obtained by Dimroth rearrangement of 2-(4-substituted phenylimino)-6-phenyl-5,6-dihydro-4H-1,3-thiazin-4-ones under the same reaction conditions. 2-(4-Substituted phenylimino)-6-phenyl-5,6-dihydro-4H-1,3-thiazin-4-ones were synthesized from the corresponding thioureas under catalysis of boron trifluoride in chloroform.

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19

Teles-Ferreira, Danielle Cristina, Rocio Borrego-Varillas, Lucia Ganzer, et al. "Intersystem crossing in thiobases proceeds by a dark intermediate state." EPJ Web of Conferences 205 (2019): 10005. http://dx.doi.org/10.1051/epjconf/201920510005.

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4-thiouracil (4TU) is studied by transient absorption spectroscopy employing sub-20 fs UV-pulses and hybrid QM(CASPT2) / MM(AMBER) computations (static and dynamic), evidencing that, along the photoexcited relaxation pathway, intersystem crossing originates from a dark intermediate state.

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20

Alcolea Palafox, M., A. Milton Franklin Benial, and V. K. Rastogi. "Biomolecules of 2-Thiouracil, 4-Thiouracil and 2,4-Dithiouracil: A DFT Study of the Hydration, Molecular Docking and Effect in DNA:RNAMicrohelixes." International Journal of Molecular Sciences 20, no. 14 (2019): 3477. http://dx.doi.org/10.3390/ijms20143477.

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The molecular structure of 2-thiouracil, 4-thiouracil and 2,4-dithiouracil was analyzed under the effect of the first and second hydration shell by using the B3LYP density functional (DFT) method, and the results were compared to those obtained for the uracil molecule. A slight difference in the water distribution appears in these molecules. On the hydration of these molecules several trends in bond lengths and atomic charges were established. The ring in uracil molecule appears easier to be deformed and adapted to different environments as compared to that when it is thio-substituted. Molecul

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21

Yamanari, Kazuaki, Makiko Kida, Akira Fuyuhiro, Masakazu Kita, and Sumio Kaizaki. "Cobalt(III) promoted ligand fusion reactions of thiobarbituric acid and 4,6-diamino-2-thiouracil (or 4-amino-2-thiouracil)." Inorganica Chimica Acta 332, no. 1 (2002): 115–22. http://dx.doi.org/10.1016/s0020-1693(02)00696-5.

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22

Lamsabhi, Al Mokhtar, Manuel Alcamí, Otilia Mó, and Manuel Yáñez. "Gas-Phase Reactivity of Uracil, 2-Thiouracil, 4-Thiouracil, and 2,4-Dithiouracil towards the Cu+ Cation: A DFT Study." ChemPhysChem 4, no. 9 (2003): 1011–16. http://dx.doi.org/10.1002/cphc.200300704.

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23

Tohei, A., M. Akai, T. Tomabechi, M. Mamada, and K. Taya. "Adrenal and gonadal function in hypothyroid adult male rats." Journal of Endocrinology 152, no. 1 (1997): 147–54. http://dx.doi.org/10.1677/joe.0.1520147.

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Abstract The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats. Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH. The pituitary responsiveness to CRH for ACTH release markedly increased, whereas t

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24

Awad, Samir, Yasser Zohny, Sahar Ali, Shahenda Mahgoub, and Ahmed Said. "Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents." Molecules 23, no. 11 (2018): 2913. http://dx.doi.org/10.3390/molecules23112913.

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Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel. There are two hydrophobic side chains directed towards the oxygen atom in the C-4 position of the thiouracil ring. In the current study, the structural activity relationship (SAR) was performed on the thiouracil nucleus of PTU to target these hydrophobic side chains

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25

Pires, Viviane Silva, Sophie da Nascimento, and Pascal Sonnet. "Synthesis of 4-Thiouracil KPGEPGPK Analogues as Potential TIIICBP Identification Tools." International Journal of Peptide Research and Therapeutics 16, no. 4 (2010): 257–66. http://dx.doi.org/10.1007/s10989-010-9227-7.

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26

Kraszewska, Karina, Iwona Kaczyńska, Stefan Jankowski, Janina Karolak-Wojciechowska, and Elzbieta Sochacka. "Desulfurization of 2-thiouracil nucleosides: Conformational studies of 4-pyrimidinone nucleosides." Bioorganic & Medicinal Chemistry 19, no. 7 (2011): 2443–49. http://dx.doi.org/10.1016/j.bmc.2011.02.008.

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27

Clivio, Pascale, Jean Louis Fourrey, Jeannette Gasche, and Alain Favre. "Synthesis of dinucleoside phosphates containing sulfur substituted nucleobases : 4-thiouracil, 4- thiothymine and 6-mercaptopurine." Tetrahedron Letters 33, no. 1 (1992): 69–72. http://dx.doi.org/10.1016/s0040-4039(00)77675-1.

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28

Clivio, Pascale, Jean Louis Fourrey, Jeannette Gasche, et al. "Synthesis and purification of oligonucleotides containing sulfur substituted nucleobases : 4- thiouracil, 4-thiothymine and 6-mercaptopurine." Tetrahedron Letters 33, no. 1 (1992): 65–68. http://dx.doi.org/10.1016/s0040-4039(00)77674-x.

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29

AHMED, Z., M. AHMED, M. IBRAHIM, M. KAMAL, and Y. TEMERK. "Chelate adsorption for trace voltammetric measurements of 2-thiouracil and 4-thiouridine." Talanta 41, no. 5 (1994): 659–62. http://dx.doi.org/10.1016/0039-9140(94)80045-6.

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30

Prasanthkumar, K. P., Cherumuttathu H. Suresh, and C. T. Aravindakumar. "Dimer radical cation of 4-thiouracil: a pulse radiolysis and theoretical study." Journal of Physical Organic Chemistry 26, no. 6 (2013): 510–16. http://dx.doi.org/10.1002/poc.3116.

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31

Tohei, A., G. Watanabe, and K. Taya. "Hypersecretion of corticotrophin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion." Journal of Endocrinology 156, no. 2 (1998): 395–400. http://dx.doi.org/10.1677/joe.0.1560395.

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The relationship between hypothyroidism and disturbance of the hypothalamo-hypophysial-adrenal axis was investigated using adult male rats. Hypothyroidism was produced by administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Hypothyroidism decreased adrenal weights to 57% of controls and plasma concentrations of corticosterone to 48% of controls. The changes in the weight of adrenals recovered to control levels by administration of thyroxine. The pituitary responsiveness to corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) for ACTH release

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32

Ibrahim, Mohamed Sayed. "Structural and Adsorption Effects of Some Thiopurine and Thiopyrimidine Derivatives on their Catalytic Activity at the Mercury Electrode." Collection of Czechoslovak Chemical Communications 59, no. 7 (1994): 1472–82. http://dx.doi.org/10.1135/cccc19941472.

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6-Thiopurine, 6-thiopurine riboside, 6-thioguanine, 6-thioguanosine, 8-thioguanosine, 2-thiouracil, 4-thiouridine, 2-thiocytosine and 2-thiocytidine are investigated by means of DC polarography and coulometry. In acid medium they give a typical catalytic hydrogen discharge wave, as shown by its parameters and the regeneration of the depolarizer during the electrode process. At pH values above 4.2 a second catalytic wave appears. Both catalytic waves possess pronounced surface characteristics, most likely due to adsorption of the molecules with differing orientations on the electrode surface. T

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33

Jalander, Lars F., and Jan-Erik Lönnqvist. "Synthesis of Alkyl- and Phenyl-2-thiouracils and 1,3-Thiazin-4-ones by Nucleophilic Substitution of Unsymmetrical Thioureas with 3-Chloropropenoates." Collection of Czechoslovak Chemical Communications 64, no. 8 (1999): 1307–15. http://dx.doi.org/10.1135/cccc19991307.

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Unsymmetrically substituted thioureas and ethyl (E)- and (Z)-3-aryl-3-chloro-2-cyano- propenoates (1a) and (1b) gave after nucleophilic vinylic substitution and cyclisation two isomers of 1,3-disubstituted 6-aryl-5-cyano-2-thiouracil derivatives, 3a-3i and 4a-4i. Substituted 1,3-thiazin-4-ones 5a-5d were formed in moderate to good yields when monosubstituted thioureas were allowed to react under similar conditions.

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34

Chaudhary, Arpana S., Jinshan Jin, Weixuan Chen, Phang C. Tai, and Binghe Wang. "Design, syntheses and evaluation of 4-oxo-5-cyano thiouracils as SecA inhibitors." Bioorganic & Medicinal Chemistry 23, no. 1 (2015): 105–17. http://dx.doi.org/10.1016/j.bmc.2014.11.017.

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35

Kajiwara, Takashi, and Tasuku Ito. "Design of complex–ligand systems based on thiouracil. A novel cyclic tetramer of cobalt(III) with 1-(2-thiouracil-4-methylene)-3,6-diazahexane." J. Chem. Soc., Chem. Commun., no. 15 (1994): 1773–74. http://dx.doi.org/10.1039/c39940001773.

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36

Krečmerová, Marcela, Hubert Hřebabecký, and Antonín Holý. "Preparation of 5-Benzyluracil and 5-Benzylcytosine Nucleosides as Potential Inhibitors of Uridine Phosphorylase." Collection of Czechoslovak Chemical Communications 61, no. 4 (1996): 627–44. http://dx.doi.org/10.1135/cccc19960627.

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Reaction of 3,4,6-tri-O-acetyl-2-deoxyglucopyranosyl bromide (1) with silylated 5-benzyluracil and subsequent ammonolysis afforded α- and β-anomers of 5-benzyl-1-(2-deoxy-D-glucopyranosyl)uracil (2 and 3). Under catalysis with tin tetrachloride, silylated 5-benzyluracil reacted with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose to give 2',3',5'-tri-O-benzoyl-5-benzyluridine (10), which was converted into the 4-thio derivative 11 by reaction with Lawesson reagent. Debenzoylation of compound 11 afforded 5-benzyl-4-thiouridine (12), whereas its reaction with methyl iodide and deblocking gave 4-me

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37

WYRZYKIEWICZ, E., Z. NOWAKOWSKA, G. BARTKOWIAK, and B. KEDZIA. "ChemInform Abstract: Synthesis and Antimicrobial Properties of S-Substituted Derivatives of 4-Thiouracil." ChemInform 28, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.199720135.

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38

Li, Xiang, Jing Chen, and Kit H. Bowen. "Photoelectron spectroscopic study of the negative ions of 4-thiouracil and 2,4-dithiouracil." Journal of Chemical Physics 134, no. 7 (2011): 074304. http://dx.doi.org/10.1063/1.3555177.

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39

Lobana, Tarlok, and Amanpreet Kaur. "Coordination variability of Copper(I) in multidonor heterocyclic thioamides." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1244. http://dx.doi.org/10.1107/s2053273314087555.

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The chemistry of copper(I) with scarcely studied heterocyclic thioamides, namely, 2,4,6-trimercaptotriazine, purine-6-thione, 2,4-dithiouracil, 2-thiouracil and pyrimidine-2-thione is described. The interaction of 2,4,6-trimercaptotriazine (tmtH3) with [Cu(CH3COO)(PPh3)2] gave rise to a pair of bond isomers : [Cu(κ1N-tmtH2)(PPh3)2] (6a), [Cu(κ1N,κ1S-tmtH2)(PPh3)2] (6b) and with copper(I) bromide and PPh3, it has formed a trinuclear complex, [Cu3Br2(κ1N,κ1S,κ2S-tmtH2)(PPh3)6] (7) with anionic tmtH2- in these complexes. The 2,4-dithiouracil with copper halides (CuCl, CuBr) and PPh3 yielded dinuc

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40

Tripathi, G. "Thyroid Hormone-Induced Changes in Cytoplasmic and Mitochondrial Proteins of a Teleost." Zeitschrift für Naturforschung C 53, no. 1-2 (1998): 120–24. http://dx.doi.org/10.1515/znc-1998-1-221.

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AbstractThe effect of triiodothyronine (T3) on the cytoplasmic and mitochondrial protein contents were studied in the liver and skeletal muscle of a freshwater teleost. The fish exposed to thiouracil for 28 days showed 1.5-2 times reduction in the total protein contents of cytoplasmic and mitochondrial fractions. A single injection of T3 to thiouracil exposed fish caused the earliest induction in the liver and skeletal muscle mitochondrial protein and the skeletal muscle cytoplasmic protein at 12 hr of lapses. However, the initial induction in the cytoplasmic protein of the liver was observed

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41

Abdel-Rahman, Adel A. H., Abd-Allah SH El-Etrawy, Ahmed E. S. Abdel-Megied, Ibrahim F. Zeid, and El Sayed H. El Ashry. "Synthesis and Antiviral Evaluation of Novel 2,3-Dihydroxypropyl Nucleosides from 2- and 4-Thiouracils." Nucleosides, Nucleotides and Nucleic Acids 27, no. 12 (2008): 1257–71. http://dx.doi.org/10.1080/15257770802086898.

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42

Shukla, M. K., and Jerzy Leszczynski. "A theoretical study of hydration of 4-thiouracil in the electronic singlet excited state." Journal of Molecular Structure: THEOCHEM 771, no. 1-3 (2006): 149–55. http://dx.doi.org/10.1016/j.theochem.2006.03.031.

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43

Rubin, Yuri V., Yuri Morozov, Divi Venkateswarlu, and Jerzy Leszczynski. "Prototropic Equilibria in 4-Thiouracil: A Combined Spectroscopic and ab Initio SCF-MO Investigation." Journal of Physical Chemistry A 102, no. 12 (1998): 2194–200. http://dx.doi.org/10.1021/jp9726798.

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44

Khodair, A. I., E. E. Ibrahim, and E. S. H. El Ashry. "Glycosylation of 2-Thiouracil Derivatives. A Synthetic Approach to 3-Glycosyl-2, 4-dioxypyrimidines." Nucleosides and Nucleotides 16, no. 4 (1997): 433–44. http://dx.doi.org/10.1080/07328319708001360.

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45

Zou, Xiaoran, Xiaojuan Dai, Kunhui Liu, Hongmei Zhao, Di Song, and Hongmei Su. "Photophysical and Photochemical Properties of 4-Thiouracil: Time-Resolved IR Spectroscopy and DFT Studies." Journal of Physical Chemistry B 118, no. 22 (2014): 5864–72. http://dx.doi.org/10.1021/jp501658a.

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46

Qiu, Zaiming, Yongmei Xia, Haijun Wang, and Kaisheng Diao. "MP2 study on the hydrogen-bonding interactions between 4-thiouracil and four RNA bases." Structural Chemistry 21, no. 1 (2009): 99–105. http://dx.doi.org/10.1007/s11224-009-9528-7.

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47

Hronowski, Lucjan J. J., та Walter A. Szarek. "Synthesis of cyclopentane analogs of 1-(2′,3′-dideoxy-β-glycero-pentofuranosyl)pyrimidine nucleosides". Canadian Journal of Chemistry 66, № 1 (1988): 61–70. http://dx.doi.org/10.1139/v88-009.

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Synthesis of new carbocyclic analogs of 1-(2′,3′-dideoxy-glycero-pentofuranosyl)pyrimidine nucleosides having the uracil (34), 2-thiouracil (33), 2-thiothymine (31), cytosine (44), and 5-methylcytosine (43) bases is described. The nucleoside analogs having the uracil, 2-thiouracil, and 2-thiothymine bases were prepared by coupling cis-3-aminocyclopentanemethanol (8) with 3-ethoxypropenoyl isocyanate (26), 3-ethoxypropenoyl isothiocyanate (25), and 3-methoxy-2-methylpropenoyl isothiocyanate (23), respectively, to give the corresponding acyl urea (30) and acyl thioureas (29 and 27). The acyl ure

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48

Fears, Thomas R., Robert M. Elashoff, and Marvin A. Schneiderman. "The Statistical Analysis of a Carcinogen Mixture Experiment. III. Carcinogens With Different Target Systems, Aflatoxin B1, N-Butyl-N-(4-Hydroxybutyl)Nitrosamine, Lead Acetate, and Thiouracil." Toxicology and Industrial Health 5, no. 1 (1989): 1–23. http://dx.doi.org/10.1177/074823378900500101.

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This paper describes factorial experiments designed to determine whether two carcinogens that lead to cancers in different organ systems act synergistically to produce cancers in Fischer 344 rats. Four carcinogens, aflatoxin B1 (AFLA), N-butyl-n-(4-hydroxybutyl)nitrosamine (NBBN), lead acetate (LA), and thiouracil (THIO) were studied in pairwise combinations. Each of the six possible pairs were studied by means of a 4 X 4 factorial experiment, each agent being fed at zero and at three non-zero doses. Methods of analysis designed explicitly for this study were derived to study interaction. Thes

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49

Mahran, Asma Mohamed, Nasser Abdelhamid Hassan, Dalia Ahmed A. Osman, Sherif Shaban Ragab, and Allam Abdelhamid Hassan. "Synthesis and biological evaluation of novel pyrimidines derived from 6-aryl-5-cyano-2-thiouracil." Zeitschrift für Naturforschung C 71, no. 5-6 (2016): 133–40. http://dx.doi.org/10.1515/znc-2015-0265.

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Abstract Starting from 6-aryl-5-cyano-2-thiouracil derivative 1a–f, a series of novel thiazolo[3,2-a]pyrimidines 4a–f were synthesized. The mechanism and the regioselectivity of the studied reactions are discussed. In addition, a series of tetrahydro-4-H-pyrimido[2,1-b][1,3]thiazines 7a–e and 2-((ethoxymethyl)thio)-4-aryl-1,6-dihydropyrimidines 9b,c,e were synthesized. The anti-microbial activities of some of the prepared compounds were screened, and the results revealed that compounds 3c and 4c were more active than the standard (Ampicillin) against gram positive bacteria (Pseudomonas aerugin

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50

Iglesias, Emilia. "Gold Nanoparticles as Colorimetric Sensors for the Detection of DNA Bases and Related Compounds." Molecules 25, no. 12 (2020): 2890. http://dx.doi.org/10.3390/molecules25122890.

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Results regarding interaction of colloidal gold solutions with nucleobases, including uracil (U), as well as its sulfur derivatives, 2-thiouracil (2TU) and 4-thiouracil (4TU), cytosine (C), adenine (A), and guanine (G), as well as urea and thiourea (TU), are reported. Anionic stabilized citrate gold nanoparticles (AuNPs) were synthesized by reducing the tetrachloroaurate (III) trihydrate with trisodium citrate. The surface plasmon resonance (SPR) band was used in the characterization of synthesized AuNPs, as well as transmission electron microscope (TEM) imaging, which was used in the characte

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