Relevant bibliographies by topics / 4-triazin

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Academic literature on the topic '4-triazin'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "4-triazin"

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Al-Romaizan, Abeer N. "Behavior of 3-hydrazino-6-aryl-1,2,4-triazin-5-one as a strong nucleophile towards active electrophilic compounds and their antibacterial evaluation." Mediterranean Journal of Chemistry 9, no. 3 (October 17, 2019): 279–57. http://dx.doi.org/10.13171/mjc93191014920aar.

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The behavior of 3-hydrazino-6-aryl-1,2,4-triazin-5-one towards the active electrophilic compounds in polar and/ or non-polar solvents and various times and temperatures, has been studied. N-[2-(3-(3/5-(4-Nitrophenyl)-5/3-thioxo-1H-1,2,4-triazol-1-yl)-5-oxo-1,2,4-triazin-6-yl)phenyl]pivalamides were obtained from the reaction of N-(2-(3-hydrazineyl-5-oxo-1,2,4-triazin-6-yl)phenyl)-pivalamide with 4-nitrobenzoyl isothiocyanate in THF and/ or EtOH-piperidine respectively. Also, N-(2-(3-hydrazineyl-5-oxo-1,2,4-triazin-6-yl)phenyl)-pivalamide was shown a strong nucleophilic behavior by reaction with N-phenyl-thiourea to produce N-[2-(5-oxo-3-(2-(phenylcarbamothioyl)-hydrazineyl)-1,2,4-triazin-6-yl)phenyl]pivalamide, which upon cyclization with diethyl carbonate produced N-(2-(5-oxo-3-(5-oxo-4-phenyl-3-thioxo-1,2,4-triazolidin-1-yl)- 1,2,4-triazin-6-yl)phenyl)pivalamide. Moreover, N-(2-(3-hydrazineyl-5-oxo-1,2,4-triazin-6-yl)phenyl)pivalamide studied its behavior by reaction with cyanoacetic acid, chloroacetonitrile, and/ or benzoyl carbonitrile to produce N-(2-(3-amino-4,8-dioxo-4H-[1,2,4]triazino[4,3-b][1,2,4]triazin-7-yl)phenyl)pivalamide,N-(2-(4-amino-8-oxo-2H-[1,2,4]triazino[4,3-b][1,2,4]triazin-7-yl)phenyl)pivalamide and N-(2-(4-imino-8-oxo-3-phenyl-4H-[1,2,4] triazino [4,3-b][1,2,4]triazin-7-yl)phenyl)pivalamide. Structure of the products was established upon their elemental analysis and FT-IR, 1H/ 13C NMR, and MS. The new compounds were evaluated as antibacterial agents some Gram-positive and negative bacteria. Some compounds were showed the highest inhibition activity towards Pseudomonas aeruginosa, Bacillus subtilis, Bacillus cereus, and Sarcina lutea bacteria and lowest inhibitory activity against Escherichia coli bacteria.
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Fuerst, E. Patrick, Michael Barrett, and Donald Penner. "Control of Triazine-Resistant Common Lambsquarters (Chenopodium album) and Two Pigweed Species (Amaranthusspp.) in Corn (Zea mays)." Weed Science 34, no. 3 (May 1986): 440–43. http://dx.doi.org/10.1017/s0043174500067151.

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Various chemical treatments were evaluated over two growing seasons for control of triazine-resistant common lambsquarters (Chenopodium albumL. # CHEAL) and for control of a triazine-resistant infestation containing both redroot pigweed (Amaranthus retroflexusL. # AMARE) and Powell amaranth (A. powelliiS. Wats. # AMAPO). Atrazine [6-chloro-N-ethyl-N′-(1-methylethyl)-1,3,5-triazine-2,4-diamine], cyanazine {2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl] amino]-2-methylpropanenitrile}, and metribuzin [4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one] provided unsatisfactory control of these biotypes. Satisfactory control of common lambsquarters was obtained with preemergence applications of pendimethalin [N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzenamine] or dicamba (3,6-dichloro-2-methoxybenzoic acid), or postemergence applications of dicamba, bromoxynil (3,5-dibromo-4-hydroxybenzonitrile), or bentazon [3-(1-methylethyl)-(1H)-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide]. Satisfactory control of pigweed was obtained with preemergence applications of alachlor [2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide] or postemergence treatments of dicamba, bromoxynil, or 2,4-D [(2,4-dichlorophenoxy) acetic acid].
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Deohate, Pradip P., and Roshani S. Mulani. "Microwave Irradiative Synthesis of Triazine Substituted Pyrazoles and Study of Antitubercular and Antimicrobial Activities." Asian Journal of Chemistry 31, no. 5 (March 28, 2019): 1087–90. http://dx.doi.org/10.14233/ajchem.2019.21826.

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Microwave irradiative synthesis of triazine substituted pyrazoles i.e. (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines have been achieved by the cyclocondensation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted acid hydrazides. Synthesis of required butyramide was done by reacting 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde and then condensing the product with ethyl acetoacetate. Structural investigation of synthesized compounds has been done by chemical transformation, elemental analysis and IR, 1H NMR, mass spectral studies. Study of antitubercular and antimicrobial activity of title compounds against some selected Gram-positive and Gram-negative microorganisms was performed to establish the relationship between structure and activity of compound.
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Collins, David J., Timothy C. Hughes, and Wynona M. Johnson. "Dihydro-1,2,4-triazin-6(1H)-ones. III. Oxidation Products of 1-Methyl-3-phenyl- 4,5-dihydro-1,2,4-triazin-6(1H)-one." Australian Journal of Chemistry 52, no. 10 (1999): 971. http://dx.doi.org/10.1071/ch99047.

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1-Methyl-3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one (1) undergoes aerial oxidation to give a mixture of 1- methyl-3-phenyl-1,2,4-triazin-6(1H)-one (2) and 1-methyl-3-phenyl-1,4-dihydro-1,2,4-triazine-5,6-dione (3). The dehydro derivative (2) was cleanly prepared by the oxidation of (1) with 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (ddq). The dehydro derivative (2) underwent a surprising rearrangement to the triazole (12) upon oxidation with OxoneR. Several attempts at unambiguous synthesis of the α-dicarbonyl derivative (3) were unsuccessful; it was obtained, together with the 1,4-dimethyl derivative (13) by methylation of 3-phenyl-1,4- dihydro-1,2,4-triazine-5,6-dione (4) with sodium hydride and methyl iodide.
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Alharbi, Abdulrahman Salim, and Nawaa Ali Alshammari. "Synthesis of some new 5-amino-3-(substituted-amino)-6-(fluoro/ nitro)aryl-1,2,4-triazine derivatives as lamotrigine analogs and their evaluation in vitro as antibacterial agents." Mediterranean Journal of Chemistry 8, no. 6 (July 28, 2019): 486–93. http://dx.doi.org/10.13171/mjc861907296asa.

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Some new fluorine-substituted 3,5-disubstituted amino-1,2,4-triazines have been obtained from aryl-amination of 2,2,2-trifluoro-N-[2-(5-hydroxy-3-thioxo-2,3-dihydro-1,2,4-triazin-6-yl)-4-nitrophenyl] acetamide followed by ammonolysis to produce N-(2-(5-amino-3-(arylamino)-1,2,4-triazin-6-yl)-4-nitrophenyl)-2,2,2-trifluoroacetamides which reacted with N-phenylthiourea. The structures of products were deduced from their elemental analysis and spectral measurements. The new lamotrigine analogs were evaluated in vitro as antibacterial. Interestingly, some compounds showed interesting activity against the Bacillus subtilis, Streptococcus faecalis, Micrococcus luteus, and Staphylococcus aureus bacteria.
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Ali, Ola Ahmad Abu. "Synthesis and Characterization Antifungal Fluorine Substituted Fused Heterobicyclic Nitrogen Systems Containing 1,2,4-triazine Moiety." Journal of Molecular Biology Research 8, no. 1 (May 2, 2018): 41. http://dx.doi.org/10.5539/jmbr.v8n1p41.

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Synthesis of some new full fluorinated heterobicyclic nitrogen systems containing 1,2,4-triazine moiety (4-10) have been deduced from heterocyclization of 6-(2'-trifluoroacetylamino)phenyl-3-(4'-fluorophenyl-1,2,4-triazin-5-one (3) with active oxo / halo-compounds. Structure of the products have been established upon their elemental and spectral date. Most of these systems exhibited a good to moderate antifungal activities.
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Latacz, Gniewomir, Annamaria Lubelska, Magdalena Jastrzębska-Więsek, Anna Partyka, Małgorzata Anna Marć, Grzegorz Satała, Daria Wilczyńska, et al. "The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment." International Journal of Molecular Sciences 20, no. 14 (July 12, 2019): 3420. http://dx.doi.org/10.3390/ijms20143420.

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Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT6R ligands can be pivotal for innovative treatment of cognitive impairment, but none has reached pharmacological market, predominantly, due to insufficient “druglikeness” properties. Recently, 1,3,5-triazine-piperazine derivatives were identified as a new chemical family of potent 5-HT6R ligands. For the most active triazine 5-HT6R agents found (1–4), a wider binding profile and comprehensive in vitro evaluation of their drug-like parameters as well as behavioral studies and an influence on body mass in vivo were investigated within this work. Results indicated the most promising pharmacological/druglikeness profiles for 4-((1H-indol-3-yl)methyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (3) and 4-((2-isopropyl-5-methylphenoxy)methyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (4), which displayed a significant procognitive action and specific anxiolytic-like effects in the behavioral tests in vivo together with satisfied pharmaceutical and safety profiles in vitro. The thymol derivative (4) seems to be of higher importance as a new lead candidate, due to the innovative, non-indole and non-sulfone structure with the best 5-HT6R binding properties.
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Kunishima, Munetaka, Daiki Kato, Nobu Kimura, Masanori Kitamura, Kohei Yamada, and Kazuhito Hioki. "Potent triazine-based dehydrocondensing reagents substituted by an amido group." Beilstein Journal of Organic Chemistry 12 (August 24, 2016): 1897–903. http://dx.doi.org/10.3762/bjoc.12.179.

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This study describes the synthesis of triazine-based dehydrocondensing reagents substituted by amido substituents and demonstrates their efficiency for dehydrocondensing reactions in MeOH and THF. N-Phenylbenzamido-substituted chlorotriazine is readily converted to a stable, non-hygroscopic triazinylammonium-based dehydrocondensing reagent that is superior to 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) in terms of its reactivity in dehydrocondensing reactions.
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Verma, Tarawanti, Manish Sinha, and Nitin Bansal. "Synthesis of Novel 1,2-Dihydro-1,2,4-Triazin-6(5H)-one Derivatives as Anticancer Agents." Current Bioactive Compounds 16, no. 7 (October 28, 2020): 1116–31. http://dx.doi.org/10.2174/1573407215666191022123310.

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Introduction: Cancer is still an untreatable disease and the second leading cause of death globally. The heterocyclic compounds have always played a major role in the anticancer drug discovery program. 1,2,4-Triazine-6-ones is a heterocyclic privileged structure with diversified activities. In the presented study, 21 novel 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6 (5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b)) have been synthesized and tested for their anticancer activity. Methods: The 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b) were synthesized by refluxing substituted-2-phenyloxazol-5(4H)-one and hydrazine derivatives. Substituted aldehydes were synthesized via Vilsmeier-Haack reaction, while substituted- 2-phenyloxazol-5(4H)-one derivatives were synthesized by Erlenmeyer Plochl azlactone synthesis. Twenty-one compounds were selected and screened at the National Cancer Institute (NCI), USA, for anticancer activity at a single high dose (10-5M) in full NCI 60 cell panel assay. Results and Conclusion: The selected compounds (13a, 13b, 13c, 13f, 13h, 13i, 13j, 18h, 18i, 21a4) were found to be active against different cancer cell lines. The compound, 5-((5-chloro-3-methyl-1- phenyl-1H-pyrazol-4-yl)methylene)-2-(4-nitrobenzoyl)-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one (13a) was found to be a potent anti-cancer agent as electron-rich moiety on phenyl at position 2 of triazine nucleus, having a great impact on anticancer activity.
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Mokhonova, Inna D., Evgenij A. Maksimov, Irina V. Ledenyona, Alevtina Y. Yegorova, and Khidmet S. Shikhaliev. "Reactions of 3H-furan-2-ones and 2H-chromen-2-ones with pyrazole-3(5)-diazonium salts." Heterocyclic Communications 24, no. 4 (August 28, 2018): 183–85. http://dx.doi.org/10.1515/hc-2017-0192.

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AbstractDerivatives of the new heterocyclic system, 6H-chromeno[4,3-e]pyrazolo[5,1-c][1,2,4]triazin-6-one, were obtained by the reaction of pyrazole-3(5)-diazonium salts with 4-hydroxy-2H-chromen-2-one. Similar reactions with 5-phenyl-3H-furan-2-one followed by intramolecular heterocyclization furnished 6-(4-halophenyl)-7-alkyl-2-phenylfuro[2,3-e]pyrazolo[5,1-c][1,2,4]triazines.
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Dissertations / Theses on the topic "4-triazin"

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Woodland, Elaine Denise. "Investigations of fused 1,2,3-triazin-4-ones and related systems." Thesis, Nottingham Trent University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304105.

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This thesis describes work carried out on several chemical aspects of fused 1,2,3-triazin-4-ones. In the first section several sUbstituted l,2,3-benzotriazinones were prepared with a view to observing their rate of deazoniation. It ,was envisaged that a kinetic analysis of this reaction would aid the elucidation of the nature of a hitherto controversial reaction intermediate. The rate constants obtained were used to construct Hammett plots and hence calculate the reaction constants. Several pieces of evidence were obtained that suggested the intermediate was of a diradical nature. Unfortunately, this could not be substantiated by Chemically Induced Dynamic Nuclear Polarisation spectroscopy. The second section involved devising a new synthetic route for the preparation of l,2,3-thieno[ 3,4-d]triazinones since the one existing preparation gave polysubstituted products. A simple thienotriazinone was obtained which was used to study the reaction conditions required to cause its deazoniation. It was envisaged that for this reaction to occur, a potentially undesirable sulphurE[intermediate must be surmounted. As anticipated the thieno[3,4-d]triazinone did not deazoniate under the normal conditions.The synthetic route used to prepare the thieno[3,4-d]triazinone also afforded an intermediate aminonitrile. An investigation into the versatility of this compound as a potential precursor to other fused heterocycles was undertaken. Several fused thienopyrimidines were obtained. The final section of this work was dedicated to devising a synthetic route for the preparation of pyrroloand furanotriazinones. Unfortunately these compounds were not obtained due to difficulties of instability and excessive water solubility encountered in the synthesis, several useful intermediates were, however, successfully prepared.
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Dupont, Carine. "Conception, synthèse et caractérisation de molécules polyhétérocycliques azotées pour la complexation spécifique de cations métalliques." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00590462.

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La loi du 6 juin 2006 sur la gestion des déchets radioactifs de haute activité et à vie longue prévoit la recherche de solutions permettant la séparation et la transmutation des radioéléments à vie longue, pour réduire les quantités et la nocivité des déchets radioactifs ultimes. Ces déchets issus du retraitement du combustible nucléaire usé sont actuellement vitrifiés à La Hague. Ainsi, le projet " séparation poussée " vise à compléter le procédé industriel PUREX par le développement de procédés permettant d'extraire les actinides mineurs des raffinats PUREX où se trouvent également des produits de fission constitués principalement de lanthanides, neutrophages. Pour réaliser la séparation poussée, les actinides mineurs des raffinats PUREX doivent être séparés par des molécules spécifiques. Les BTP ou bis-triazinyl-pyridines ont été largement étudiées au CEA pour la séparation actinides(III)/lanthanides(III). Elles complexent sélectivement les actinides, mais l'origine de cette sélectivité n'est pas complètement expliquée : notamment l'influence des groupements (attachés à leur structure) sur la complexation ou la sélectivité reste à démontrer. En outre, elles sont sensibles à l'hydrolyse et à la radiolyse. La première partie du travail présente la synthèse de BTP ou de BTBP, différemment substituées pour améliorer leur résistance face à l'hydrolyse ou à la radiolyse, et une nouvelle famille de ligands polyaromatiques azotés : les BPBT, présentant un enchaînement original de cycles pyridine et triazine, différent de toutes les structures décrites jusqu'à présent dans la littérature. La seconde partie de ce travail est consacrée à l'étude physico-chimique de nouvelles molécules obtenues, en déterminant leurs constantes de protonation et de complexation, pour connaître l'influence des différents groupements sur la complexation et la sélectivité. Enfin, le troisième volet concerne l'étude des propriétés de ces ligands en extraction liquide-liquide, utilisés soit comme extractants lipophiles, soit comme complexants hydrophiles.
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FIOROT, R. G. "Síntese e Estudo de Ancoragem Molecular de Novos Híbridos Contendo Os Núcleos 1,4-naftoquinônico, Quinolínico e 1,3,5-triazínico Com Potencial Atividade Antineoplásica." Universidade Federal do Espírito Santo, 2015. http://repositorio.ufes.br/handle/10/4744.

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Made available in DSpace on 2016-08-29T15:35:41Z (GMT). No. of bitstreams: 1 tese_9160_Rodolfo Goetze Fiorot.pdf: 12436359 bytes, checksum: f6d3dc79a76780f5d4d2ad8a84ce69cc (MD5) Previous issue date: 2015-09-04
O câncer é uma das doenças mais temidas pela sociedade, sendo uma das principais causas de morte em todo o mundo. Desta maneira, estudos contínuos buscando compreender seus mecanismos de evolução são imprescindíveis para que se possa erradica-lo do organismo. Embora a quimioterapia seja amplamente empregada em praticamente todos os casos de câncer, a resistência a múltiplas drogas tende a diminuir a eficiência deste tratamento. Para contornar esta problemática, o conceito de hibridação molecular vem sendo explorado entre os químicos orgânicos sintéticos, a fim obter fármacos variados que explorem diferentes mecanismos de ação. Nas últimas décadas, a descoberta de vias de sinalização superexpressas em células cancerosas permitiu uma nova abordagem na terapêutica com efeitos colaterais diminuídos nos pacientes e eficiência elevada. Dentre elas, as enzimas PI3K e AMPK merecem destaque por constituírem vias de sinalização que desencadeiam uma grande quantidade de outras enzimas envolvidas no progresso do câncer, como Akt, mTOR e ERK 1/2. Neste contexto, o presente trabalho está baseado na síntese e estudo de ancoragem molecular utilizando as enzimas PI3K e AMPK como proteínas- alvo de híbridos contendo os núcleos naftoquinonas, quinolinas e triazinas - com reconhecida atividade antitumoral. Os resultados de ancoragem mostraram que a maioria dos híbridos propostos possui energia de interação receptor/ligante superiores aos fármacos controle para suas respectivas enzimas, sugerindo a inibição dessas vias de sinalização como possível forma de ataque ao câncer. Além disso, a natureza das interações e os resíduos de aminoácidos envolvidos na formação do complexo receptor/ligante são semelhantes para os fármacos controle e os candidatos propostos, corroborando com a assertiva feita acerca do mecanismo de ação baseada na análise da magnitude da energia de interação. Resultados satisfatórios também foram alcançados na síntese dos candidatos a fármaco: um híbrido quinolínico-naftoquinônico 120, um triazino- naftoquinônico 125 (ambos inéditos) e um triazino-quinolínico 127 foram sintetizados.
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Le, Falher Laetitia. "Préparation et dérivatisation de 4H-pyrido[e][1,3]oxazinones : une contribution à la diversité chimique." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066344.

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Ce manuscrit porte sur la synthèse et les applications d'une nouvelle série de composés hétéroaromatiques : les 4H-pyrido[e][1,3]oxazin-4-ones. La première partie de ce manuscrit présente la préparation de ces squelettes via une réaction d'O-arylation intramoléculaire. La seconde partie du manuscrit repose sur la réactivité de ces entités chimiques et de leur utilisation en tant qu'intermédiaires de synthèse. La fonctionnalisation des 4H-pyrido[e][1,3]oxazin-4-ones, via des réactions de couplage pallado-catalysées, a permis d'obtenir des systèmes polyfonctionnalisés plus complexes. Les pyrido-oxazinones ont également été transformées, en une étape, en divers petits hétérocycles d'intérêt : les 1,3,5-triazines, les 1,2,4-triazoles et les 1,2,4-oxadiazoles. La dernière partie du manuscrit est consacrée à l'utilisation des molécules synthétisées comme potentielles sondes fluorescentes pour la détection de protéines oxydées
This work focused on the synthesis and applications of a novel series of heteroaromaticcompounds: the 4H-pyrido[e][1,3]oxazin-4-ones. The first part of this thesis presents thepreparation of these pyrido-oxazinones via an intramolecular O-arylation reaction. The secondpart of this work relies on the reactivity of these chemical entities and their use as buildingblocks. The functionalization of the 4H-pyrido[e][1,3]oxazin-4-ones has been studied viacross-coupling reactions to obtain more elaborated structures. The pyrido-oxazinones werealso converted, in one step, into other diverse small molecules of interest: 1,3,5-triazines,1,2,4-triazoles and 1,2,4-oxadiazoles. The last part of this thesis was devoted to the use of theobtained heterocycles as potential fluorescent probes for the detection of carbonylatedproteins
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Edmont, Blotière Dolores. "Synthèse et réactivité de la 6-fluoro-4-oxo-1, 4-dihydro-2-quinoléinecarboxylate de méthyle : Elaboration de novuelles molécules tricycliques à structure 1,2,4-triazino. Evaluation biologique dans le domaine hypoglycémiant." Orléans, 1999. http://www.theses.fr/1999ORLE2009.

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Le diabete mellitus, maladie metabolique, est un syndrome de plus en plus frequent, qui se rencontre a tous les ages de la vie. Des donnees recentes revelent l'existence d'environ 130 millions de diabetiques dans le monde et leur nombre pourrait bien doubler d'ici 2025. Dans le cadre d'une recherche de nouveaux agents hypoglycemiants permettant de traiter les causes et les consequences du diabete non insulino-dependant, nous avons prepare, a partir d'un synthon de base de 6-fluoro-4-oxo-1,4-dihydro-2-quinoleinecarboxylate de methyle, des composes du type 4-oxo-1,4-dihydroquinoleinique diversement substitues en position 2, ainsi que des nouveaux composes tricycliques a structure 1h-1,2,4triazino1,6-a ou 4,5-aquinoleinique. Ainsi, dans un premier temps, le choix de methodes de guanylation, l'utilisation de semicarbazide ou d'aminotetrazole, ont permis de realiser la synthese de diverses (2-quinoleinyl)carbonylguanidines, de (2-quinoleinyl)carbonyl-1-hydrazinecarboximidamide, de (2-quinoleinyl)carbonyl-1-hydrazinecarboxamide ou encore de n-(1h-1,2,3,4-tetraazol-5-yl)-2-quinoleinecarboxamide. Dans un second temps, la synthese de deux nouvelles familles de molecules tricycliques que sont les derives de la 8-fluoro-1h-1,2,4triazino4,5-aquinoleine-1,6(2h)-dione et la 8-fluoro-1h-1,2,4triazino1,6-aquinoleine-2,4,6(3h)-trione a permis d'acceder a des composes potentiellement actifs par introduction de pharmacophores de type acetique, propanoique, methyltetrazole ou ethyltetrazole. Les resultats des tests pharmacologiques, effectues sur des rats wistar par la societe lipha-merck, sur certaines des molecules synthetisees, permettent de conclure quant a l'importance de divers pharmacophores sur l'activite hypoglycemiante et sont particulierement encourageants pour les deux nouvelles familles de molecules tricycliques.
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Badarau, Eduard. "Conception, synthèse et évaluation biologique de nouvelles classes de ligands sérotoninergiques 5-HT7." Phd thesis, Université d'Orléans, 2009. http://tel.archives-ouvertes.fr/tel-00480279.

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Parmi tous les neurotransmetteurs identifiés à ce jour, la sérotonine (5-hydroxytryptamine, 5-HT) est impliquée dans le système le plus complexe de récepteurs. Parmi eux, les récepteurs 5-HT7 qui sont les derniers découverts (1993) semblent avoir des implications multiples tant au niveau central que périphérique. Le potentiel thérapeutique représenté par la découverte de ligands 5-HT7 sélectifs vis-à-vis d'autres RCPGs a motivé notre projet de recherche. Nos études sont orientées vers la conception de trois classes distinctes de ligands. Une première famille à été conçue sur une charpente benzimidazolone. Diverses pharmacomodulations ont permis un changement du profil d'activité de 5-HT1A vers 5-HT7. Une deuxième famille de composés à structure furo- ou pyrano[2,3-b] pyridinique constitue des analogues azotés d'un des plus intéressants agonistes sélectifs 5-HT7 actuels. La synthèse de ces dérivés a été conduite via la mise en oeuvre d'une étape clé de cycloaddition intramoléculaire de Diels-Alder à partir de 1,2,4-triazines judicieusement fonctionnalisées en 3 par une chaine aminoalkynol. Cette méthodologie nous a permis de faire varier les substituants alkyle de l'amine, la nature et la position du motif aryle sur le noyau pyridinique, ainsi que la taille du cycle non-aromatique. La synthèse d'une dernière famille de dérivés bisaryliques a enrichi les études de relation structure-activité, connues dans la littérature, associées à ce type de ligands 5-HT7. La variation du cycle aromatique central (phényle, 1,3-diazine et 1,2,4- triazine) a révélé d'importantes conséquences sur l'affinité des molécules.
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Leconte, Nicolas. "Synthèse et caractérisation de molécules polyhétérocycliques azotées pour la complexation de cations metalliques polluants." Phd thesis, Université d'Orléans, 2007. http://tel.archives-ouvertes.fr/tel-00465122.

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La séparation des actinides(III) du mélange actinides(III)/lanthanides(III) constitue un problème crucial dans le retraitement du combustible nucléaire usé. Il a été montré expérimentalement que les dérivés de la 2,6-bis(1,2,4-triazin-3-yl)pyridine (BTP) sont capables d'extraire sélectivement les actinides(III) par rapport aux lanthanides(III). Cependant, les propriétés de ces molécules doivent être améliorées pour afficher de meilleures performances d'extraction et pour résister aux conditions dures du milieu à extraire. Des ligands fonctionnalisés de manière originale ont été synthétisés puis testés en milieu actif. Par ailleurs, le contrôle et la détection des actinides(III) en phase aqueuse pourraient être réalisés à l'aide d'un capteur chimique tel que la micro-balance à quartz. L'étude de faisabilité de ce dispositif a nécessité la conception préalable de structures complexantes originales dérivées de la BTP. Le dernier volet de ce travail repose sur l'étude de nouvelles voies d'accès au motif BTP. La réaction de couplage croisé catalysé au palladium entre la 3-méthylsulfanyl-1,2,4- triazine et diverses pyridines stannylées a été explorée. Les recherches ont également permis de développer une méthode de synthèse de 1,2,4,5-tétrazines non symmétriques à partir de la 3-méthylsulfanyl-6-(morpholin-N-yl)-1,2,4,5-tétrazine et des dérivés d'acides boroniques et organostanniques.
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DU, MOULIN DE LA BRETECHE MARIE-LAURE. "Modification de composes aromatiques en conditions douces : bioconversion de la 2-chloro 4-ethylamino 6-isopropylamino 1,3,5-triazine ou atrazine ; etude de la nitrosation de phenols substitues et des catecholamines." Paris 11, 1994. http://www.theses.fr/1994PA112320.

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La chimie en conditions douces s'avere une alternative de choix, a la fois lors de l'etude de molecules sensibles aux conditions de ph et d'oxydo-reduction, et lors de l'etude des processus physiologiques. L'illustration de ces methodes a ete realisee dans le cas de la biodegradation de l'atrazine, herbicide qui s'accumule dans les sols et dans l'eau et de la reactivite des nitrites sur les phenols. La bioconversion de l'atrazine a ete effectuee par des microorganismes issus du milieu naturel. Les champignons filamenteux rhizopus arrhizus, curvularia lunata et beauveria bassiana transforment l'atrazine en plusieurs metabolites dont le desethylatrazine et le 5-n-oxyde atrazine. Une souche microbienne degrade l'atrazine via l'hydroxyatrazine. L'accumulation de ces composes permet de souligner l'inadequation des normes de qualite des eaux qui ne tiennent pas compte de la presence des metabolites qui se forment a partir de l'atrazine par des microorganismes issus du milieu naturel. La nitrosation de phenols substitues tels le 2-chloro phenol, le 4-terbutyl phenol et le resorcinol a ete realisee en presence de nitrite de sodium a des ph de 2,6 a 7. Le mecanisme reactionnel compose d'une premiere etape de nitrosation suivie de l'oxydation en compose nitre est discute. Cette methode de nitrosation en conditions douces a ete appliquee a des composes biologiquement actifs: l'adrenaline, la noradrenaline et la dopamine. Nous avons etudie la reactivite des catecholamines vis a vis du monoxyde d'azote et des ions nitrites, issus de la reaction d'autoxydation de no dans l'eau. Les catecholamines par reaction avec no en presence d'oxygene ou avec le nitrite a ph inferieur a 6 conduisent aux derives nitres en position 6. Ces composes pourraient se former lors de l'administration de no par inhalation chez des malades en detresse respiratoire. La nitro-6 adrenaline ne presente plus les proprietes de l'adrenaline dans l'aggregation plaquettaire et la reponse pressive
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Pochet, Sylvie. "Synthèse d'oligodésoxynucléotides comportant des sites ambigus ou apuriniques et de sondes ancrées à un support solide." Paris 6, 1986. http://www.theses.fr/1986PA066065.

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Synthèse et étude par spectroscopies RMN, IR et DC d'oligodésoxyribonucléotides contenant un résidu sans base: coexistence des conformations b et z sur un même duplex. Elaboration d'une base universelle dans la série des nucléosides pyrimidiques. Synthèse d'oligodésoxynucléotides ancrés à un support solide; applications.
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Hajbi, Youssef. "Application de la réaction de Diels-Alder à demande électronique inverse à la synthèse de nouveaux composés oxygénés et azotés à visée thérapeutique." Phd thesis, Université d'Orléans, 2007. http://tel.archives-ouvertes.fr/tel-00151105.

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Cette thèse s'inscrit dans une volonté de développer de nouvelles architectures hétéroaromatiques susceptible de montrer un potentiel thérapeutique. Pour cela la synthèse de dihydrofuro[2,3-b]pyridines et dihydropyrano[2,3-b]pyridines hautement et diversement fonctionnalisées est apparue particulièrement intéressante notamment en vue de l'obtention de nouveaux analogues sérotoninergiques. L'accès à ces nouveaux squelettes a été réalisé via une réaction intramoléculaire de Diels-Alder à demande électronique inverse avec des 1,2,4-triazines.

Pour ce faire, des 3-méthylsulfanyl-1,2,4-triazines ont été mis à réagir avec différents nucléophiles permettant l'introduction d'alcynes convenablement substitués. La réactivité de ces alcynes selon une réaction de Diels-Alder à demande électronique inverse a été explorée. L'activation par micro-ondes de la réaction de cycloaddition s'est avérée très efficace. Des dihydrofuro[2,3-b]pyridines diversement substituées en position 2, 3, 4, et/ou 6 et des dihydropyrano[2,3-b]pyridines substituées en position 3, 4, 5 et/ou 7 ont été synthétisées avec de bons rendements.
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Books on the topic "4-triazin"

1

Neunhoeffer, Hans, and Paul F. Wiley. Chemistry of 1 2 3-Triazines and 1 2 4-Triazines, Tetrazines, and Pentazin. Wiley & Sons, Incorporated, John, 2009.

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Book chapters on the topic "4-triazin"

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van Lierop, Ben, Laurence Castle, Alexandre Feigenbaum, and Achim Boenke. "2,4-Bis(octylmercapto)-6-(4-hydroxy-3,5-di-tert-butylanilino)-1,3,5-triazine." In Spectra for the Identification of Additives in Food Packaging, 85–89. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5222-8_17.

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van Lierop, Ben, Laurence Castle, Alexandre Feigenbaum, and Achim Boenke. "Poly[6-[(1,1,3,3-tetramethylbutyl)amino]-1,3,5-triazine-2,4-diyl]-[(2,2,6,6-tetramethyl-4-piperidyl)-imino]hexamethylene[(2,2,6,6-tetramethyl-4-piperidyl)imino]." In Spectra for the Identification of Additives in Food Packaging, 416–20. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5222-8_82.

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van Lierop, Ben, Laurence Castle, Alexandre Feigenbaum, and Achim Boenke. "1,3,5-Tris(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3,5-triazine-2,4,6(1H,3H,5H)trione." In Spectra for the Identification of Additives in Food Packaging, 515–19. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5222-8_102.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with 3-hydrazino-5, 6-diphenyl-1, 2, 4-triazine." In Magnetic Properties of Paramagnetic Compounds, 338. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53974-3_175.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) complex with 3-hydrazino-5, 6-diphenyl-1, 2, 4-triazine." In Magnetic Properties of Paramagnetic Compounds, 674–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_347.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of chromium(III) complex with 3-hydrazino-5, 6-diphenyl-1, 2, 4-triazine." In Magnetic Properties of Paramagnetic Compounds, 934–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_458.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(II) complex with 3-hydrazino-5, 6-diphenyl-1, 2, 4-triazine." In Magnetic Properties of Paramagnetic Compounds, 1296–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_635.

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Sartori, G., and R. Maggi. "1,3,5-Oxadiazin-4-ones, 1,3,5-Thiadiazin-4-ones, 1,3,5-Triazin-2-ones, and 1,2,4-Triazin-3-ones." In Four Carbon-Heteroatom Bonds, 1. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-018-00903.

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Döpp, H., and D. Döpp. "Rearrangement of Annulated 3-Substituted 1,2,3-Triazin-4(3)-imines." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-00484.

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Aggarwal, P., and M. W. P. Bebbington. "Cyclization of 3-Amino-1,2,4-triazin-5(4)-ones with Glyoxal." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles, 1. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-117-00251.

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Conference papers on the topic "4-triazin"

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Xiang, Haoyue, Xiang Wang, Yanhong Chen, Xi Zhang, Yi Chen, Cun Tan, Yi Wang, Jian Ding, Ling-Hua Meng, and Chunhao Yang. "Abstract LB-268: Discovery of clinical candidate methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) : A highly potent and selective PI3K alpha inhibitor for the treatment of advanced solid tumors." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-lb-268.

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Anichina, K. "SYNTHESIS AND ANTINEMATODAL ACTIVITY STUDIES OF SOME FUSED TRIAZINOBENZIMIDAZOLES." In International Trends in Science and Technology. RS Global Sp. z O.O., 2020. http://dx.doi.org/10.31435/rsglobal_conf/30122020/7351.

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4-Aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines 3a-f were synthesized in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatilebenzaldehydes. Structures of all prepared compounds were confirmed by IR, 1H NMR spectroscopyand elemental analysis.Antinematodal activity in vitro of the substances was investigated using isolated Trichinella spiralis muscle larvae. The tested triazonobenzimidazoles showed different activity depending on the substituent R in their moleculeas the derivatives substituted with a hydroxyl group demonstrated the best anti-Trichinella spiralis activity in the series.
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Dolzhenko, Anton, Anna Dolzhenko, and Wai-Keung Chui. "Reaction of 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]-benzimidazoles with diethyl ethoxymethylenemalonate." In The 10th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01381.

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Dolzhenko, Anton, Anna Dolzhenko, and Wai-Keung Chui. "Synthesis of Fused 2-amino-4-oxo-1,3,5-triazines via Microwave-Assisted Ring Closure Carbonylation of Azahetarylguanidines." In The 9th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01635.

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Reports on the topic "4-triazin"

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Stromer, Bobbi, Rebecca Crouch, Katrinka Wayne, Ashley Kimble, Jared Smith, and Anthony Bednar. Methods for simultaneous determination of 29 legacy and insensitive munition (IM) constituents in aqueous, soil-sediment, and tissue matrices by high-performance liquid chromatography (HPLC). Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/1168142105.

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Standard methods are in place for analysis of 17 legacy munitions compounds and one surrogate in water and soil matrices; however, several insensitive munition (IM) and degradation products are not part of these analytical procedures. This lack could lead to inaccurate determinations of munitions in environmental samples by either not measuring for IM compounds or using methods not designed for IM and other legacy compounds. This work seeks to continue expanding the list of target analytes currently included in the US Environmental Protection Agency (EPA) Method 8330B. This technical report presents three methods capable of detecting 29 legacy, IM, and degradation products in a single High Performance Liquid Chromatography (HPLC) method with either ultraviolet (UV)-visible absorbance detection or mass spectrometric detection. Procedures were developed from previously published works and include the addition of hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX); hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine (DNX); hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX); 2,4-diamino-6-nitrotoluene (2,4-DANT); and 2,6-diamino-4-nitrotoluene (2,6-DANT). One primary analytical method and two secondary (confirmation) methods were developed capable of detecting 29 analytes and two surrogates. Methods for high water concentrations (direct injection), low-level water concentrations (solid phase extraction), soil (solvent extraction), and tissue (solvent extraction) were tested for analyte recovery of the new compounds.
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