Academic literature on the topic '4-triazole derivatives'

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Journal articles on the topic "4-triazole derivatives"

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Karpun, Yevhen, and Nataliia Polishchuk. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. http://dx.doi.org/10.15587/2519-4852.2021.235976.

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The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)t
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Yevhen, Karpun, and Polishchuk Nataliia. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. https://doi.org/10.15587/2519-4852.2021.235976.

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<strong>The aim of the work.</strong>&nbsp;1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1
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Syrota, Natalia O., Sergiy V. Kemskiy, Lesya M. Saliyeva, and Mykhailo V. Vovk. "1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles." Journal of Organic and Pharmaceutical Chemistry 20, no. 2 (2022): 27–51. http://dx.doi.org/10.24959/ophcj.22.258512.

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Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems.Results and discussion. Original literature sources revealing the synthetic potential of 4(5)-amino functionalized 1,2,3-triazoles as convenient and available building blocks for the preparation of triazolo-annulated pyridines, azines and azepines were analyzed and systematized. Condensation of 1,2,3-triazole-4(5)-amines with methylene active compounds was shown to be a powerful tool for the synthesis of vers
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GAMAL, A. AHMED. "Studies on 3-Amino-I ,2,4-triazole." Journal of Indian Chemical Society Vol. 74, Aug 1997 (1997): 624–25. https://doi.org/10.5281/zenodo.5891468.

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Department of Chemistry , Faculty of Science, Zagazig University, Zagazig, Egypt <em>Manuscript received 16 October 1995, revised 18 June 1996, accepted 24 July 1996</em> 1,2,4-Triazolo[2,3-a]-1,3,5-triazine-4-aryl-4-thiones (3a,b) and 5-(aroylamino)-1,2,4-triazoles (5a,b) have been synthesised by the reaction of 3-amino-1,2,4-triazole (1) with aroyl isothiocyanates. Also, 1 when reacted with cinnamonitrile derivatives yields the trlazolopyrimldine derivatives (6, 7a,b and 8). Treatment of 8 with carbon disulphide and formaide gives 9 and 10 respectively. Some of the compounds possess antimicr
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Murthy Appala, Venkata Ramana, Kanaka Durga Bhavani Anagani, and Aparna Pasula. "Synthesis of New Piperidine based N(2)-Alkylated 1,2,3-Triazole Hybrids in Basic Medium." Asian Journal of Chemistry 35, no. 1 (2022): 212–16. http://dx.doi.org/10.14233/ajchem.2023.26906.

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The nucleophilic reaction of 1H-triazole derivatives with piperidines under basic conditions is the essential step in the synthesis of a new series of dibenzyl N(2)-C-linked triazolyl piperidines. The triazole derivative was synthesized via the CuAAc reaction of 1-phenylprop-2-yn-1-ol (1a-b) with azidomethyl pivalate. Compound 3a-b underwent dehydroxylation and deprotection reactions using TFA, triethyl silane and 1 M NaOH respectively, yielding monobenzyl 1H-1,2,3-triazole (4a-b). The N(2)-piperidinyltriazoles (6a-j) were synthesized in significant amounts by nucleophilically reacting 1H-tria
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Gotsulya, A. S., A. I. Panasenko, E. G. Knysh, and A. O. Pryimenko. "UV-spectrophotometric study of the 7-((3-thio-4-R-1,2,4-triazole-3-yl)methyl)-theophyllines." Farmatsevtychnyi zhurnal, no. 4 (September 4, 2018): 65–70. http://dx.doi.org/10.32352/0367-3057.4.15.03.

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Chemistry of the 1,2,4-triazole derivatives recently attracts the attention of many scientists, mainly due to the presence of the number of the valuable pharmacological properties. In modern medical practice, there are many examples of successful heterocyclic systems derivatives usage. First of all, it is a group of drugs with antifungal activity (fluconazole, itraconazole, voriconazole, pozakonazol), antidepressant activity (alprazolam, triazolam), anticancer activity (anastrozole, letrozole). But despite the great practical importance of works in this area, the structure of 1,2,4-triazoles-3
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Frolova, Yu S., A. H. Kaplaushenko, T. V. Ihnatova, and T. M. Kaplaushenko. "Synthesis methods of 1,2,4-triazole-3-thiones: review." Current issues in pharmacy and medicine: science and practice 17, no. 2 (2024): 187–96. http://dx.doi.org/10.14739/2409-2932.2024.2.302616.

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1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human body. The aim of the study was to analyze in detail and combine the available literature materials to study the reactions associated with the formation of different classes of derivatives of 1,2,4-triazole-3-thione and to study their physical-chemical properties. Various innovative methods have been proposed and explored for synthesizing differen
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Shakeel Ahmed, Shiza Murad, Iqra Munir, et al. "Spectroscopic Investigation and Synthesis of N-Ethyl-5-Tolyloxymethyl Triazole Derivatives." Indus Journal of Bioscience Research 3, no. 5 (2025): 288–96. https://doi.org/10.70749/ijbr.v3i5.1234.

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High-nitrogen heterocycles' synthesis has attracted much interest because of their wide applicability in many different sectors. As a significant class of organic compounds, triazoles and their fused derivatives have emerged among these. A new triazole derivative, 4-ethyl-3-ethylthio-5-(p-tolyloxymethyl)-4H-1, 2, 4-triazole, is the subject of this work on synthesis and spectrum characterization. Ethyl 2-p-tolyloxy acetate is synthesized by reacting 3, 4-dimethoxyphenylacetic acid with ethanol under concentrated H2SO4, starting the process. The ester product is subsequently transformed into 2-p
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Hryhorka, H. V., М. М. Fizer, О. І. Fizer, A. O. Kryvoviaz, and M. V. Slivka. "SYNTHESIS AND CHEMICAL PROPERTIES OF 2-HEPTADECYL-[1,3]THIAZOLO[3,2-b][1,2,4]TRIAZOL-7-IUM CATION." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 67–72. http://dx.doi.org/10.24144/2414-0260.2022.2.67-72.

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Functional and condensed derivatives of 1,2,4-triazoles are mostly used as biologically active compounds, and modern studies increasingly report their successful use as surfactants, stabilizers for the formation of nanoparticles, components of hybrid perovskites, which are promising materials for opto-electronics.&#x0D; Synthesis of new [1,3]thiazolo[3,2-b][1,2,4]triazol-7-ium salts containing a long-chain heptadecyl substituent was proposed within our research. The production of the starting compounds (2-heptadecyl-4-methyl-1,2,4-triazole-3-thione and methallyl thioether of 2-heptadecyl-3-mer
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Md, Akram* Abdul Sayeed Mohd Waseem Akram MD Ather Ali Soherwardi. "STUDIES ON THE SYNTHESIS OF SOME NEW 1,2,4- TRIAZOLES DERIVATIVES AND EVALUATION FOR THEIR ANTI-FUNGAL ACTIVITY PROFILES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2234–48. https://doi.org/10.5281/zenodo.839545.

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The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3- hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a- 6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4- yl)isonicotinamide (5) and aliphatic dica
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Dissertations / Theses on the topic "4-triazole derivatives"

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Qi, Chunyan. "Evaluation of the Effects of a Series of 1,2,3-Triazole Derivatives on LipopolysaccharideInduction of Interleukin 6 in a Human Macrophage Cell Line." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1389020204.

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Ni, Xiang-Ru, and 倪湘茹. "Triazole Functionalized Calix[4]quinone Derivatives as Highly Selective Ion Sensor." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/86db3z.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>104<br>In this study, we modified the lowerrim of the calix[4]arene by attaching distal pyrene unit as the fluorophore through the click chemistry of pyrene azides with 25, 27bispropargyl calix[4]arene. Based on the methods developed by Ms. YingJung Chen, we successfully synthesized the unique skeleton of calix[4]quinone and its derivatives 3336. Based on the results from UVVis spectroscopy and fluorescence spectrometry, we found that fluorescence emission intensity decreased, because more flexible structure will cause energy lost in the cases of 33; 34 posses
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Chang, Sheng-Yu, and 張勝育. "Syntheses of Anthryl and Pyrenyl Triazole Substituted Calix[4]thiacrown Derivatives as Fluorogenic Sensors in Ionic Recognition." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/11246132082132498407.

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碩士<br>國立交通大學<br>應用化學系所<br>97<br>In this work, a series of novel fluoroionophores 20-24 were synthesized. The structure of 20-22 featured anthrance moiety and 24 featured pyrene moiety as the fluorophore. The thiacrown and triazole groups as metal ion recongnition sites were modyfied and incorporated into the cone and 1,3-alternate conformations of calix[4]arene. The photo-physical properties of compounds 20-24 in acetonitrile were measured which provided evidence for the allosteric effect of compounds. The binding ability of compounds 20-23 toward Ag+ and Pb2+ were studied first. Stern-Volme
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Li, Nola Hua. "X-ray crystallographic studies of a 4-demethoxythiodaunomycinone derivative and 1,2,4-triazole." 1988. http://hdl.handle.net/1993/16753.

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Gau, Ai Hua, and 高愛華. "1,3-diastereoselective ene reaction of 4-phenyl-1,2,4- triazoline -3,5-dione with allylic alcohol derivatives." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/73826081912148967746.

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Wang, Yu-Yun, and 王雨筠. "The Synthesis of Calix[4]arenes with (1) Distal Anthryl-triazoles and Acid Derivatives (2) Distal Bis-Pyrenyl-ester-triazoles for Metal Ion Sensing Studies." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/18427518349799494126.

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碩士<br>國立交通大學<br>應用化學系所<br>97<br>(1) The Synthesis of calix[4]arenes with Distal Anthryl-triazoles and Acid Derivatives for Metal ion Sensing Studies. We used the Click Chemistry to modify the lower rim of calix[4]arenes with a triazole cationic binding site, and an anthracene as a fluorophore. After we incorporating a second acid derivatives group into 5a, compounds 6a�{9a were obtained as fluoroionophores for metal ions. Compounds 5a�{9a and control compound 10a showed fluorescence quenching toward Cu2+, Hg2+, and Cr3+ ions. Besides that, 6a also showed a slight fluorescence quenching towa
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Chen, Tyng-Rong, and 陳庭蓉. "(I)Hydrogen, Halogen Bonding and Metal Ion-Induced Two Component Gel Formation of Triazolyl-pyridyl Substituted Calix[4]arene Derivatives (II)Syntheses of bis-Isoxazolyl-aryl Substituted Biscalix[4]arene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/jvy7sf.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>102<br>In recent years, calix[4]arene derivatives have been extensively studied in supramolecular gel formation. Although they can be used in ions recognition and oil spill recovery, they usually form one component gels. Two component gel formation of calix[4]arene was not known until Prof. Zheng’s work published in 2007. It worth noting that there have been few reports on using halogen bonding as intermolecular forces for gel formation. In this thesis, we used click chemistry reaction to synthesize triazolyl-pyridyl substituted calix[4]arene derivatives 33 , whic
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Chen, Yu-Jen, and 陳俞臻. "(1) Temperature and Matrix Effects Dependence on the Triplet Radical Pairs Generated from Photolysis of N-Tosylpyrrole Derivatives, (2) Photochemistry of Heteroaromatic Fused ??-1,2,3-Triazoline Derivatives, (3) Application of Tetrazole Modified Calix[4]a." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/54411936287525538177.

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博士<br>國立交通大學<br>應用化學研究所<br>98<br>In part 1, the photolysis (230-325 nm) of N-tosyl pyrrole 37, 2-phenyl-N-tosyl pyrrole 72, 2,5-diphenyl-N-tosyl pyrrole 73, and N-(2-naphthyl)-sulfonyl pyrrole 75 in a 2-methyltetrahydrofuran glassy matrix at 4 K gives electron paramagnetic resonance (EPR) spectra with triplet characteristics; the zero-field-splitting (zfs) parameters D' for the corresponding radical pairs (RPs) 93, 94, 95, and 96 are 0.0239, 0.0190, 0.0174, and 0.0241 cm-1, respectively. Irradiation of 37 at RT allows the isolation of two rearranged products 38 and 39 and a polymeric material
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Book chapters on the topic "4-triazole derivatives"

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Theodoridis, George, Kathleen M. Poss, and Frederick W. Hotzman. "Herbicidal 1-(2,4-Dihalo-5-phenoxyphenyl)-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazolin-5(1H)-one Derivatives." In ACS Symposium Series. American Chemical Society, 1995. http://dx.doi.org/10.1021/bk-1995-0584.ch008.

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Deshmukh, M. B., S. R. Yankanchi, S. M. Deshmukh, and Bhagawan Patil. "SYNTHESIS AND BIOLOGICAL INVESTIGATIONS OF NEWLY SYNTHESIZED SUBSTITUTED IMIDAZOLE [2, 1-C] [1, 2, 4] TRIAZOLE DERIVATIVES FROM IMIDACLOPRID." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 1. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdcs1ch7.

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New molecules with promising insecticidal properties like imidazo[2,1-c][124] triazole analogs were synthesized, starting with imidacloprid and bio-assayed. The structures of synthesized molecules were confirmed with diverse modern methods like FT-IR, 1H NMR, 13C NMR, and Mass spectrometry. The synthesized molecules are screened to investigate their insecticidal and anti-bacterial activity. The bioassay screening showed that synthesized compounds chloro (3-(4-chlorophenyl)-7-[(6-chloropyridin-3-yl)methyl]-2,5,6,7-tetrahydro-3H-imidazo [2,1-c] [1,2,4] triazole (4b), the 3-(2-chlorophenyl)-7-[(6
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Ostrowska, K., and A. Kolasa. "Synthesis from 4-Phenyl-1,2,4-triazole-3,5-dione or Dialkyl ­Azodicarboxylate." In Three Carbon-Heteroatom Bonds: Amides and Derivatives; Peptides; Lactams. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-022-00608.

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Ashraf, Naira, and Moieza Ashraf. "Response of Growth Inhibitor Paclobutrazol in Fruit Crops." In Prunus. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92883.

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Paclobutrazol (PBZ; IUPAC name: (2RS, 3RS)-1-(4-chlorophenyl)-4, 4-dimethyl-2-(1H-1, 2, 4-triazol-1-yl) pentan-3-ol) is a triazol derivative and an antagonist of gibberellins. It has been shown to inhibit shoot growth in various perennial fruit trees. Paclobutrazol application reduced the number of shoots, transforming trees into a more desirable, spur-type growth habit as the vegetative sink was reduced. This compound induces an early and intense flowering, diminishing vegetative growth and reducing the extension of buds, allowing for ripening and the initiation of apical buds inflorescence.
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Kawka, Anna, Hanna Koenig, and Tomasz Pospieszny. "From squalamine to triazole ring derivatives: Exploring the versatility of steroidal bioconjugates." In Studies in Natural Products Chemistry. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-443-15756-1.00009-4.

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Conference papers on the topic "4-triazole derivatives"

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Holm, R., J. Over, M. Wittig, et al. "Surface Analytical Investigation of the Impact of Chlorine on Triazole Inhibitor Layers on Copper." In CORROSION 1993. NACE International, 1993. https://doi.org/10.5006/c1993-93354.

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ABSTRACT Benzotriazole and its derivatives, tolyltriazole and butylbenzotriazole, have proven themselves as excellent corrosion inhibitors for copper and copper alloys under a wide variety of conditions. Chlorine, a popular oxidizing biocide in the industrial water treatment industry, has been reported to affect the protective triazole inhibitor layer (film) formed on copper. In an attempt to expand further on the interaction between chlorine and the triazole inhibitor layer, surface analyses were employed on tolyl triazole and butyl benzotri azole and the results compared to previously report
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Mykhailiuk, Yevhenii, and Ivan Bilai. "ANALGESIC ACTIVITY OF 4-R-5-PYRIDINE-1,2,4-TRIAZOLE-3-THIOL DERIVATIVES IN THE EXPERIMENT." In Scientific research, findings, and developments in technology in modern science. Publishing House “Baltija Publishing”, 2022. http://dx.doi.org/10.30525/978-9934-26-204-3-17.

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Eliwi, Amjad Gali, Zainab Zuhair Mohammad Ali, Fouad A. AL-Saady, Shaemaa Hadi Abdulsada, and Abdul Jabar Khlaf Atia. "Synthesis and acetyl cholinesterase inhibitory activity of new oxazole, 1, 2, 4 - triazole derivatives bearing carbamazepine as nucleus." In 2ND INTERNATIONAL CONFERENCE ON MATERIALS ENGINEERING & SCIENCE (IConMEAS 2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0000455.

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Bilan, Dmitri, Sergiu Cojocari, Natalia Sucman, Eughenia Stingaci, and Fliur Macaev. "Transforming the five-membered ring d in a pregnenolone derivative into a six-membered ring through skeletal rearrangement." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab22.

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In pursuit of obtaining steroid derivatives containing a triazole moiety in their structure, a series of reactions was conducted (Figure 1). In these reactions, an intermediate compound was the corresponding azide 3, which was subsequently involved in a reaction with the required alkyne to form a 1,2,3-triazole. In click chemistry reactions, it is well-known that catalysts are one-valent copper salts, which can be generated in situ from copper(II) salts. However, the NMR spectra of the main product, isolated from the reaction mass, did not match the expected results.Figure 1. The procedure for
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Szafrański, Krzysztof, Jarosław Sławiński, and Anna Kawiak. "Synthesis of Novel N-{[4-(1,2,3-Triazol)pyridin-3-yl]sulfonyl}urea Derivatives With Potential Anticancer Activity." In 3rd International Electronic Conference on Medicinal Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04684.

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Gharib, Ali, Mina Roshani, and Manouchehr Jahangir. "Efficient Catalytic Synthesis of Pyrazolo[3,4-d]pyrimidine, Pyrazolo[4,3- e][1,2,4]triazolo[1,5-c]pyrimidine, Pyrazolo[4,3-e][1,2,4]triazolo[1,5- c]pyrimidine, Pyrazolo[3,4-d]pyrimidin-4-one derivatives using Heterogeneous Preyssler Heteropolyacid, H14[NaP5W30O110]/SiO2." In The 13th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00169.

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