Relevant bibliographies by topics / 4AC 1 CELL TINE

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Academic literature on the topic '4AC 1 CELL TINE'

Author: Grafiati
Published: 11 September 2023
Last updated: 19 July 2025

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Journal articles on the topic "4AC 1 CELL TINE"

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Sakao, Kozue, Hanako Saruwatari, Shohei Minami, and De-Xing Hou. "Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells." International Journal of Molecular Sciences 24, no. 23 (2023): 16652. http://dx.doi.org/10.3390/ijms242316652.

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Quercetin, a flavonoid compound widely distributed in many plants, is known to have potent antitumor effects on several cancer cells. Our previous study revealed that the acetylation of quercetin enhanced its antitumor effect. However, the mechanisms remain unknown. This study aimed to elucidate the bioavailability of acylated quercetin in the HepG2 cell model based on its antitumor effect. The positions of quercetin 3,7,3′,4′-OH were acetylated as 3,7,3′,4′-O-tetraacetylquercetin (4Ac-Q). The inhibitory effect of 4Ac-Q on HepG2 cell proliferation was assessed by measuring cell viability. The
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Roth, Z., and P. J. Hansen. "324SPHINGOSINE-1-PHOSPHATE PROTECTS CULTURED BOVINE OOCYTES FROM PHYSIOLOGICALLY RELEVANT THERMAL STRESS." Reproduction, Fertility and Development 16, no. 2 (2004): 282. http://dx.doi.org/10.1071/rdv16n1ab324.

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Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that can block the sphingomyelin cell-death pathway by suppressing ceramide-induced apoptosis. The present study was performed to test whether S1P protects oocytes from heat shock during in vitro maturation. Cumulus-oocyte complexes obtained by slicing follicles were placed in maturation medium with or without 50nM S1P and cultured at 38.5°C (CON) or 41°C (41C) for the first 12h of maturation. Incubation during the last 10h of maturation (22-h total maturation time), fertilization, and embryonic development were performed at 38.5°C and
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Mohankumar, Kumaravel, Gus Wright, Subhashree Kumaravel, et al. "Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 236. http://dx.doi.org/10.1158/1538-7445.am2022-236.

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Abstract Colorectal cancer (CRC) is a highly complex disease with multiple risk factors. The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in several cancers and is a negative prognostic factor for cancer patient survival. Previous reports indicate a potential role for overexpression of NR4A1 in T-cell exhaustion and in this study, we aim to investigate the antitumorigenic activity of two bis-indole derived ligands (DIMs) that act as receptor antagonists. Immune competent C57BL/6 mice and mouse MC-38 colon cancer cells were used and tumor Infiltrating Lymphocytes (TILs) were isolated fr
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Mohankumar, Kumaravel, Gus Wright, Subhashree Kumaravel, et al. "732 A novel nuclear receptor 4A1 (NR4A1) antagonists attenuates T-cell exhaustion in colorectal cancer." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A761—A762. http://dx.doi.org/10.1136/jitc-2021-sitc2021.732.

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BackgroundColorectal cancer (CRC) is a highly complex disease with multiple risk factors and both genetic and environmental components contribute to disease incidence.1 2 Cancer immunotherapy using immune-checkpoint blockades represents a major advance in treatment strategy.3 4 The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in lung, colon, liver and breast cancers and in Rhabdomyosarcoma and is a negative prognostic factor for cancer patient survival.5–8 Previous studies in breast cancer cells showed that PD-L1 was regulated by NR4A1 which activates transcription factor Sp1 bound to
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D'Angelo, Sandra P., Steven Attia, Jean-Yves Blay, et al. "Identification of response stratification factors from pooled efficacy analyses of afamitresgene autoleucel (“Afami-cel” [Formerly ADP-A2M4]) in metastatic synovial sarcoma and myxoid/round cell liposarcoma phase 1 and phase 2 trials." Journal of Clinical Oncology 40, no. 16_suppl (2022): 11562. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.11562.

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11562 Background: Afami-cel is an autologous, HLA-A*02-restricted, specific peptide enhanced affinity receptor, T-cell therapy engineered to target MAGE-A4+ solid tumors. The pivotal, 2-cohort, single-arm, Phase 2, SPEARHEAD-1 trial (NCT04044768) with afami-cel met its primary endpoint based on Cohort 1 data. As of September 1, 2021, in 47 patients (pts) with metastatic synovial sarcoma (SyS) or myxoid/round cell liposarcoma (MRCLS), the overall response rate (ORR) per independent review was 34% with encouraging durability (Van Tine, et al. Paper 30: CTOS 2021; Virtual). To identify potential
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D'Angelo, Sandra P., Steven Attia, Jean-Yves Blay, et al. "Identification of response stratification factors from pooled efficacy analyses of afamitresgene autoleucel (“Afami-cel” [Formerly ADP-A2M4]) in metastatic synovial sarcoma and myxoid/round cell liposarcoma phase 1 and phase 2 trials." Journal of Clinical Oncology 40, no. 16_suppl (2022): 11562. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.11562.

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11562 Background: Afami-cel is an autologous, HLA-A*02-restricted, specific peptide enhanced affinity receptor, T-cell therapy engineered to target MAGE-A4+ solid tumors. The pivotal, 2-cohort, single-arm, Phase 2, SPEARHEAD-1 trial (NCT04044768) with afami-cel met its primary endpoint based on Cohort 1 data. As of September 1, 2021, in 47 patients (pts) with metastatic synovial sarcoma (SyS) or myxoid/round cell liposarcoma (MRCLS), the overall response rate (ORR) per independent review was 34% with encouraging durability (Van Tine, et al. Paper 30: CTOS 2021; Virtual). To identify potential
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Lunt, Colin, Sandra P. D’Angelo, Albiruni Ryan Abdul Razak, et al. "Abstract A038: Enrollment of pediatric and adolescent patients with MAGE-A4+ advanced synovial sarcoma into cohort 2 of SPEARHEAD-1: a phase 2 trial of afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4])." Clinical Cancer Research 28, no. 18_Supplement (2022): A038. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a038.

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Abstract Background: Afami-cel is an autologous, specific peptide enhanced affinity receptor T-cell therapy genetically engineered to target MAGE-A4+ solid tumors in HLA-A*02+ patients. SPEARHEAD-1 (NCT04044768) is a Phase 2, two-cohort, single-arm, open-label trial evaluating afami-cel in patients with advanced/metastatic synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) and is the largest trial in metastatic synovial sarcoma to date. Preliminary data from Cohort 1 in 47 heavily pre-treated patients aged 16–75 years from 22 centers in North America and Europe, showed an overall respon
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Labonte, Melissa Janae, Pierre Oliver Bohanes, Dongyun Yang та ін. "Novel colon cancer tumor suppressor gene, β-defensin 1, to predict recurrence in patients with stage II and III colon cancer." Journal of Clinical Oncology 30, № 15_suppl (2012): 3622. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3622.

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3622 Background: Human β-defensin 1 (hBD-1) encoded by the DEFB1 gene is an antimicrobial peptide involved in the innate immune response and is expressed in epithelial cells, including the colon. hBD-1 has been shown to have tumor suppressor functions in urothelial cancer models. We tested whether 4 germline single nucleotide polymorphisms (SNPs) in DEFB1 could predict time to tumor recurrence (TTR) in stage II and III colon cancer (CC) patients. We then sought to demonstrate if hBD-1 has tumor suppressor functions in CC models. Methods: A total of 234 patients, 105 stage II and 129 stage III,
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Welsh, James, Danxia Ke, Nahum Puebla Osorio, et al. "376 Radiation sub-study to characterize safety and tolerability of low-dose radiation in combination with afami-cel in patients with advanced cancers (NCT03132922)." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A407. http://dx.doi.org/10.1136/jitc-2021-sitc2021.376.

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BackgroundAutologous cell therapies with an engineered T-cell receptor targeting MAGE-A4 have shown responses in patients with synovial sarcoma1 with additional responses in myxoid/round cell liposarcoma (MRCLS), head and neck, lung, esophagogastric junction, and melanoma cancers.2 3 Low-dose radiation may control tumor growth locally and modulate stroma of solid tumors,4 potentially facilitating T-cell infiltration into tumors and antitumor activity.MethodsSub-study designed to assess safety, tolerability, and efficacy in up to 10 patients with low-dose radiation in combination with lymphodep
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Giles, David, Timothy Woodiwiss, Rowland Han, et al. "SURG-48. LASER INTERSTITIAL THERMAL THERAPY REMODELS THE TUMOR IMMUNE LANDSCAPE IN A MOUSE GLIOMA MODEL." Neuro-Oncology 26, Supplement_8 (2024): viii284—viii285. http://dx.doi.org/10.1093/neuonc/noae165.1127.

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Abstract BACKGROUND Laser interstitial thermal therapy (LITT), a minimally invasive surgical technique for tumor ablation, is increasingly being used to treat primary and recurrent glioma. While the primary goal of using LITT has been to destroy tumor tissue, little is known about the impact of LITT on the overall immune response. To investigate changes in the tumor immune landscape, we utilized a mouse model of LITT and applied it to a poorly immunogenic mouse model of glioma. METHODS SB28 glioma cells were implanted in the right frontal lobe of C57BL/6 mice, and on day 7, an optical fiber is
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Dissertations / Theses on the topic "4AC 1 CELL TINE"

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SHRENI, SAKSHI DWADASH. "IDENTIFICATION OF ACTIVE COMPONENTS DERIVED FROM NK RESISTANT CELL LINE RESPONSIBLE FOR NK CELL MODULATION." Thesis, 2016. http://dspace.dtu.ac.in:8080/jspui/handle/repository/14794.

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1. ABSTRACT There are various mechanism by which, tumors are able to escape from the immune attack of NK cells. The various mechanisms are related to the NK cell adhesion or activation interventions, triggered inhibition and NK cell modulation of effector functions through the interplay of huge pool of receptors on NK cell surface. NK cells are blessed with the innate ability to kill target cell. Thus, they have a major role to defend tumors as well as cells infected by viruses. The sensitivity of infected cell to NK cell lysis may open new prospectives for NK cell-based immunotherapy. Natura
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Conference papers on the topic "4AC 1 CELL TINE"

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Baker, Brendon M., Amy M. Silverstein, Roshan P. Shah, and Robert L. Mauck. "Engineering the Functional Maturation of Nanofiber-Based Human Meniscus Tissue." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19685.

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The meniscus is a fibrous tissue essential to healthy knee mechanics. It functions to redirect vertical forces laterally, converting compressive into tensile loads which are taken up by an array of highly organized collagen fibers. Load transmission is not only the operative mode of the meniscus, but is also required for normal development and homeostatic maintenance [1]. With injury, disruption of the aligned collagen fiber architecture impairs function, altering joint loading and initiating osteoarthritis. Toward engineering replacement meniscus tissue, we have investigated scaffolds of alig
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