Relevant bibliographies by topics / 4EBP

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '4EBP'

Author: Grafiati
Published: 4 June 2021
Last updated: 21 February 2023

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Journal articles on the topic "4EBP"

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Carroll, Matthew, John Dyer, and Wayne S. Sossin. "Serotonin Increases Phosphorylation of Synaptic 4EBP through TOR, but Eukaryotic Initiation Factor 4E Levels Do Not Limit Somatic Cap-Dependent Translation in Aplysia Neurons." Molecular and Cellular Biology 26, no. 22 (2006): 8586–98. http://dx.doi.org/10.1128/mcb.00955-06.

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ABSTRACT The target of rapamycin (TOR) plays an important role in memory formation in Aplysia californica. Here, we characterize one of the downstream targets of TOR, the eukaryotic initiation factor 4E (eIF4E) binding protein (4EBP) from Aplysia. Aplysia 4EBP contains the four critical phosphorylation sites regulated by TOR as well as an N-terminal RAIP motif and a C-terminal TOS site. Aplysia 4EBP was hypophosphorylated in synaptosomes, and serotonin addition caused a rapamycin-sensitive increase in 4EBP phosphorylation both in synaptosomes and in isolated neurites. Aplysia 4EBP was regulate
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Bi, Chengfeng, Xiaoyan Zhang, Zhang Xuan, Wing C. Chan, Timothy McKeithan, and Kai Fu. "Prediction and Optimization of the Therapeutic Effect of mTOR Inhibitors in Aggressive B-Cell Lymphomas." Blood 126, no. 23 (2015): 4441. http://dx.doi.org/10.1182/blood.v126.23.4441.4441.

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Abstract Mechanistic target of rapamycin complex 1 (mTORC1) is a central integrator of nutrient and growth factor inputs that controls cell growth in all eukaryotes. Rapamycin and its analogs (rapalogs) have been approved for the treatment of relapsed mantle cell lymphoma. A large proportion of aggressive B-cell lymphoma patients, however, respond poorly to rapalogs. The second generation of mTOR inhibitors function as ATP-competitive inhibitors (TORi), directly targeting the mTOR catalytic site. TORis have been proven to be more effective than rapalogs in cancer treatment. However, the mechan
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Shives, Katherine, Aaron Massey, Nicholas May, Thomas Morrison, and J. Beckham. "4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression." Viruses 8, no. 10 (2016): 287. http://dx.doi.org/10.3390/v8100287.

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Rivera-Calderón, Luis G., Carlos E. Fonseca-Alves, Priscila E. Kobayashi, Márcio Carvalho, Rosemeri O. Vasconcelos, and Renée Laufer-Amorim. "p-mTOR, p-4EBP-1 and eIF4E expression in canine prostatic carcinoma." Research in Veterinary Science 122 (February 2019): 86–92. http://dx.doi.org/10.1016/j.rvsc.2018.11.006.

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Grech, Godfrey, Montserrat Blázquez-Domingo, Andrea Kolbus, et al. "Igbp1 is part of a positive feedback loop in stem cell factor–dependent, selective mRNA translation initiation inhibiting erythroid differentiation." Blood 112, no. 7 (2008): 2750–60. http://dx.doi.org/10.1182/blood-2008-01-133140.

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Abstract Stem cell factor (SCF)–induced activation of phosphoinositide-3-kinase (PI3K) is required for transient amplification of the erythroblast compartment. PI3K stimulates the activation of mTOR (target of rapamycin) and subsequent release of the cap-binding translation initiation factor 4E (eIF4E) from the 4E-binding protein 4EBP, which controls the recruitment of structured mRNAs to polysomes. Enhanced expression of eIF4E renders proliferation of erythroblasts independent of PI3K. To investigate which mRNAs are selectively recruited to polysomes, we compared SCF-dependent gene expression
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Toshniwal, Ashish G., Sakshi Gupta, Lolitika Mandal, and Sudip Mandal. "ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development." Developmental Cell 49, no. 3 (2019): 473–89. http://dx.doi.org/10.1016/j.devcel.2019.04.008.

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Yadav, Anil, Vinoth Kumar, David Bailey, and Byeong-Churl Jang. "AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK." International Journal of Molecular Sciences 20, no. 2 (2019): 363. http://dx.doi.org/10.3390/ijms20020363.

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Overexpression of Pim kinases has an oncogenic/pro-survival role in many hematological and solid cancers. AZD1208 is a pan-Pim kinase inhibitor that has anti-cancer and anti-adipogenic actions. Here, we investigated the effects of AZD1208 on the growth of 93T449 cells, a differentiated human liposarcoma cell line. At 20 µM, AZD1208 was cytotoxic (cytostatic) but not apoptotic, reducing cell survival without DNA fragmentation, caspase activation or increasing cells in the sub G1 phase; known apoptotic parameters. Notably, AZD1208 reduced phosphorylation of signal transducer and activator of tra
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Zhou, Yonglan, Hongyi Fang, Shenghui Lin, et al. "Qiliqiangxin Protects Against Cardiac Ischemia-Reperfusion Injury via Activation of the mTOR Pathway." Cellular Physiology and Biochemistry 37, no. 2 (2015): 454–64. http://dx.doi.org/10.1159/000430368.

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Background/Aims: Qiliqiangxin (QL) has been used for the treatment of chronic heart failure in China. Accumulating evidence suggests QL's cardio-protective effects on continuous myocardial ischemia. However, it is unclear whether QL has beneficial effects on cardiac ischemia-reperfusion (I/R) injury. Methods: A mouse model of cardiac I/R was established by ligation of the left anterior descending coronary artery for 45 minutes followed by reperfusion. The mice were treated with QL for three days before surgery and continually after I/R. Triphenyltetrazolium chloride staining, echocardiography
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Ananieva-Stoyanova, Elitsa A., Christie Adam, Rebekah Betar, Alexander Martin, Susan Hutson, and Michael Boyer. "Emerging role of the mitochondrial branched-chain aminotransferase (BCATm) as an immunosuppressive enzyme during CD4+ T cell activation." Journal of Immunology 206, no. 1_Supplement (2021): 53.04. http://dx.doi.org/10.4049/jimmunol.206.supp.53.04.

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Abstract The mitochondrial branched-chain aminotransferase (BCATm) catalyzes the transamination of leucine, an amino acid that is essential for the upregulation of complex 1 of the mammalian target of rapamycin (mTORC1) during T cell activation. Because BCATm is responsible for the mitochondrial degradation of leucine, we hypothesized that BCATm limits leucine availability for mTORC1 signaling and subsequently suppresses T cell activation. To test the hypothesis, we isolated CD4+T cells from the global BCATmKO mouse and measured the rates of leucine transamination/oxidation, the activity of th
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Hsieh, Andrew C., Maria Costa, Ornella Zollo, et al. "Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E." Cancer Cell 17, no. 3 (2010): 249–61. http://dx.doi.org/10.1016/j.ccr.2010.01.021.

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Dissertations / Theses on the topic "4EBP"

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NAPOLI, ILARIA. "How the fragile X mental retardation protein represses protein synthesis: a mechanism of translational control in dendrites." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/765.

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La Sindrome dell'X Fragile è la forma di ritardo mentale ereditario più frequente nella popolazione con un'incidenza 1/4000 nei maschi e 1/6000 nelle femmine. La patologia è causata da mutazioni nel gene FMR1 il cui prodotto proteico, FMRP, è altamente espresso nei neuroni. FMRP è una proteina che lega gli RNA messaggeri neuronali e si localizza lungo i dendriti e gli assoni dei neuroni dove controlla il trasporto e la sintesi proteica dei messaggeri associati. Nel presente progetto abbiamo analizzato il meccanismo attraverso il quale FMRP regola la sintesi proteica alle sinapsi, caratteri
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Henderson, Valerie. "Alterations in translational control by eIF4E-Homologous Protein (4EHP)." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107637.

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Tight, yet dynamic, control of translation is critical in order for the cell to respond appropriately to intracellular and extracellular cues. This translational control is achieved by modulating the rate of translation in an mRNA-specific or global manner, often by targeting the protein factors that constitute the translational machinery itself. The function of one such translation initiation factor in mammals, eIF4E Homologous Protein (4EHP), has remained elusive. This is despite evidence from 4EHP's homolog in Drosophila (d4EHP) showing it to act as a translational repressor during embryoni
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Chen, Jun-Duo. "Identification of a novel putative interaction between elF4H and 4EBP1." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66823.

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In general, translation Initiation is considered the rate-limiting step of protein synthesis for most mRNAs. Therefore, great interest and effort has been directed at defining protein factors involved in the regulation of initiation. The role of one particular initiation factor, eIF4H, has yet to be conclusively defined. Therefore, we utilized a protein fragment complementation assay (PCA) method to detect possible interacting partners of eIF4H. We identified a novel interaction between eIF4H and 4E-BP1. In vitro we were able to confirm their interaction. However, we failed t
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Ler, Lian Wee. "Identification and characterization of novel mammalian eIF4E-Homologous Protein (4EHP) interacting proteins." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66760.

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Translation of an mRNA begins with the recruitment of the eIF4F complex to the 5' cap of the mRNA and is completed upon start codon recognition by the preinitiation complex. Regulation of translation initiation is a major mechanism for the control of gene expression. The focus of this thesis is human 4EHP (h4EHP), a homolog of the cap-binding translation initiation factor eIF4E. 4EHP can bind to the cap structure but cannot initiate cap-dependent translation. Drosophila 4EHP functions as a translational repressor of specific mRNAs by forming a "closed loop", in which the bind
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Karlsson, Elin. "Clinical potential of the mTOR effectors S6K1, S6K2 and 4EBP1 in breast cancer." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104180.

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The prognosis of patients diagnosed with breast cancer has been considerably improved in the latest 25 years, as a result of continuous development of diagnostics and treatment regimens. Though, tumour diseases, for woman mainly lung cancer and breast cancer, still constitute of the most common causes of death in developed countries, following heart diseases. A future utopia is to develop more individualised therapy strategies, to further increase breast cancer survival, but also to decrease  the risk of severe side-effects of unnecessary treatments. Normal mammary gland development is regulat
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Brueschke, Andrea. "Regulation of translation initiation by phosphorylation of eIF4E and the eIF4E-binding proteins (4EBPs)." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78333.

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eIF4F is a complex of three polypeptides: eIF4E, the cap binding protein, eIF4A, an RNA helicase and eIF4G, a large polypeptide which serves as a molecular bridge between the mRNA and the ribosome. eIF4E is the least abundant of the initiation factors in most cell types making it a crucial target for translational control. Two important mechanisms involved in regulating eIF4E activity are its phosphorylation at serine 209 and the binding of the inhibitory 4E binding proteins (4EBPs).<br>eIF4E becomes phosphorylated in response to extracellular stimuli such as growth factors, mitogens an
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Rivera, Calderón Luis Gabriel. "Avaliação da expressão gênica e protéica da via mTOR/4EBP1/eIF4E nos carcinomas prostáticos caninos." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153863.

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Submitted by LUIS GABRIEL RIVERA CALDERON (lgriveramvz@gmail.com) on 2018-05-02T17:50:21Z No. of bitstreams: 1 Tese_Luis_Gabriel_Rivera_Calderon.pdf: 12272198 bytes, checksum: 78d4519bb4d6661c6d6284b28f290374 (MD5)<br>Rejected by Alexandra Maria Donadon Lusser Segali null (alexmar@fcav.unesp.br), reason: Solicitamos que sejam feitas as correções listadas abaixo: O arquivo PDF submetido no repositório deve conter ficha catalográfica e certificado de aprovação (documentos obrigatórios). Favor inserir os mesmos no arquivo PDF e fazer novamente a submissão. Agradecemos a compreensão. o
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Mastrandrea, Nicholas Joseph. "Pentoxifylline As An Adjuvant Treatment In Renal Cell Carcinoma." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337293.

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Cyclin D1, a proto-oncogene, is required for progression from the G1 phase into the S phase of the cell cycle. Over-expression of cyclin D1 causes an increase in cell cycle progression and cell proliferation, implicating it in a variety of cancers including renal cell carcinoma (RCC). The rodent RCC cell model, QTRRE, and human RCC cell models, ACHN, 786-O and Caki-2, exhibit elevated levels of cyclin D1. Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, is an FDA-approved hemorheologic agent used to treat intermittent claudication, stemming from peripheral vascular diseases, a
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Marucha, Kevin [Verfasser], and Christine [Akademischer Betreuer] Clayton. "The suppressive role of 4EIP and PUF3 in gene expression during differentiation of Trypanosoma brucei / Kevin Marucha ; Betreuer: Christine Clayton." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1177045559/34.

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Tang, Yubo. "Traditional Chinese Medicine extracts exert angiogenic and protective effects towards human endothelial progenitor cells: from cellular function to molecular pathway." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144400.

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Despite intense research efforts, the repair of large bone defects is still not satisfactory and remains a major challenge in Orthopaedic Surgery. In this context bone tissue engineering has emerged as a promising strategy. However, one of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Thus an active blood vessel network is an essential pre-requisite for scaffold constructs to integrate within existing host tissue. Currently, great efforts are made to address this problem employing
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Book chapters on the topic "4EBP"

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Appuhamy, J. A. D. R. N., and M. D. Hanigan. "Modeling the effects of insulin and amino acids on the phosphorylation of mTOR, Akt, and 4EBP1 in mammary cells." In Modelling nutrient digestion and utilisation in farm animals. Wageningen Academic Publishers, 2011. http://dx.doi.org/10.3920/978-90-8686-712-7_25.

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Conference papers on the topic "4EBP"

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Vergez, Sébastien, Christelle Tavergnier, Philippe Rochaix, et al. "Abstract 725: eIF4E/4eBP-1 as predictive factor(s) of response to EGFR targeted drug in head and neck cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-725.

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Tibrewal, Nidhi, James B. Aggen, Abraham I. Bassan, et al. "Abstract PR04: 4EBP1 reactivation by potent and selective bi-steric inhibitors of mTORC1." In Abstracts: AACR Special Conference on Targeting PI3K/mTOR Signaling; November 30-December 8, 2018; Boston, MA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3125.pi3k-mtor18-pr04.

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Earwaker, Philip, Frances Willenbrock, Andrew Protheroe, and Valentine Macaulay. "Abstract 3593: Raptor upregulation contributes to maintenance of 4EBP1 phosphorylation and TORC kinase resistance in renal cancer cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3593.

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Wang, Chunmei, Lijie Jiang, Biao Fan, et al. "Abstract 2248: Both rpS6 and 4EBP1 are required for the carcinogenesis induced by coactivation of AKT and Ras." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2248.

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Mahauad-Fernandez, Wadie D., Yu C. Yang, Ian Lai, et al. "Abstract 1002: A bi-steric mTORC1 inhibitor that selectively reactivates 4EBP1 and induces regression of MYC-driven hepatocellular carcinoma." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1002.

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Mühlenberg, Thomas, Julia Ketzer, Jonathan A. Fletcher, and Sebastian Bauer. "Abstract 377: Novel mTOR inhibitor MLN0128 inhibits imatinib-resistant GIST more potently than rapalogues by abrogating AKT and 4EBP1 activation." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-377.

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Wen, Yun-Fei, Ying Wang, Shaolin Ma, Anca Chelari Raicu, Keith A. Baggerly, and Anil K. Sood. "Abstract 3720: Blockade of the short-form of prolactin receptor induces FOXO3a/EIF-4EBP1-mediated cell death in uterine cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3720.

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Wen, Yun-Fei, Ying Wang, Shaolin Ma, Anca Chelari Raicu, Keith A. Baggerly, and Anil K. Sood. "Abstract 3720: Blockade of the short-form of prolactin receptor induces FOXO3a/EIF-4EBP1-mediated cell death in uterine cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3720.

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Ito, Hiromi, Sei Naito, Osamu Ichiyanagi та ін. "Abstract 4120: Acquisition of chemoresistance to mTORC1 inhibition due to activation of the GSK-3 β/4EBP1 pathway might predict poor prognosis of mRCC patients". У Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4120.

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Dalenc, F., S. Le Guellec, L. Arnould, et al. "Abstract P3-14-13: eIF4E/4EBP1 axis and response to neoadjuvant trastuzumab-based treatment in HER2+ breast cancer – Results of a multicentre French retrospective cohort." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p3-14-13.

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