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Dissertations / Theses on the topic '4EBP'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

NAPOLI, ILARIA. "How the fragile X mental retardation protein represses protein synthesis: a mechanism of translational control in dendrites." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/765.

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La Sindrome dell'X Fragile è la forma di ritardo mentale ereditario più frequente nella popolazione con un'incidenza 1/4000 nei maschi e 1/6000 nelle femmine. La patologia è causata da mutazioni nel gene FMR1 il cui prodotto proteico, FMRP, è altamente espresso nei neuroni. FMRP è una proteina che lega gli RNA messaggeri neuronali e si localizza lungo i dendriti e gli assoni dei neuroni dove controlla il trasporto e la sintesi proteica dei messaggeri associati. Nel presente progetto abbiamo analizzato il meccanismo attraverso il quale FMRP regola la sintesi proteica alle sinapsi, caratteri

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Henderson, Valerie. "Alterations in translational control by eIF4E-Homologous Protein (4EHP)." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107637.

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Tight, yet dynamic, control of translation is critical in order for the cell to respond appropriately to intracellular and extracellular cues. This translational control is achieved by modulating the rate of translation in an mRNA-specific or global manner, often by targeting the protein factors that constitute the translational machinery itself. The function of one such translation initiation factor in mammals, eIF4E Homologous Protein (4EHP), has remained elusive. This is despite evidence from 4EHP's homolog in Drosophila (d4EHP) showing it to act as a translational repressor during embryoni

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Chen, Jun-Duo. "Identification of a novel putative interaction between elF4H and 4EBP1." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66823.

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In general, translation Initiation is considered the rate-limiting step of protein synthesis for most mRNAs. Therefore, great interest and effort has been directed at defining protein factors involved in the regulation of initiation. The role of one particular initiation factor, eIF4H, has yet to be conclusively defined. Therefore, we utilized a protein fragment complementation assay (PCA) method to detect possible interacting partners of eIF4H. We identified a novel interaction between eIF4H and 4E-BP1. In vitro we were able to confirm their interaction. However, we failed t

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Ler, Lian Wee. "Identification and characterization of novel mammalian eIF4E-Homologous Protein (4EHP) interacting proteins." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66760.

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Translation of an mRNA begins with the recruitment of the eIF4F complex to the 5' cap of the mRNA and is completed upon start codon recognition by the preinitiation complex. Regulation of translation initiation is a major mechanism for the control of gene expression. The focus of this thesis is human 4EHP (h4EHP), a homolog of the cap-binding translation initiation factor eIF4E. 4EHP can bind to the cap structure but cannot initiate cap-dependent translation. Drosophila 4EHP functions as a translational repressor of specific mRNAs by forming a "closed loop", in which the bind

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Karlsson, Elin. "Clinical potential of the mTOR effectors S6K1, S6K2 and 4EBP1 in breast cancer." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104180.

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The prognosis of patients diagnosed with breast cancer has been considerably improved in the latest 25 years, as a result of continuous development of diagnostics and treatment regimens. Though, tumour diseases, for woman mainly lung cancer and breast cancer, still constitute of the most common causes of death in developed countries, following heart diseases. A future utopia is to develop more individualised therapy strategies, to further increase breast cancer survival, but also to decrease the risk of severe side-effects of unnecessary treatments. Normal mammary gland development is regulat

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Brueschke, Andrea. "Regulation of translation initiation by phosphorylation of eIF4E and the eIF4E-binding proteins (4EBPs)." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78333.

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eIF4F is a complex of three polypeptides: eIF4E, the cap binding protein, eIF4A, an RNA helicase and eIF4G, a large polypeptide which serves as a molecular bridge between the mRNA and the ribosome. eIF4E is the least abundant of the initiation factors in most cell types making it a crucial target for translational control. Two important mechanisms involved in regulating eIF4E activity are its phosphorylation at serine 209 and the binding of the inhibitory 4E binding proteins (4EBPs).<br>eIF4E becomes phosphorylated in response to extracellular stimuli such as growth factors, mitogens an

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Rivera, Calderón Luis Gabriel. "Avaliação da expressão gênica e protéica da via mTOR/4EBP1/eIF4E nos carcinomas prostáticos caninos." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153863.

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Submitted by LUIS GABRIEL RIVERA CALDERON (lgriveramvz@gmail.com) on 2018-05-02T17:50:21Z No. of bitstreams: 1 Tese_Luis_Gabriel_Rivera_Calderon.pdf: 12272198 bytes, checksum: 78d4519bb4d6661c6d6284b28f290374 (MD5)<br>Rejected by Alexandra Maria Donadon Lusser Segali null (alexmar@fcav.unesp.br), reason: Solicitamos que sejam feitas as correções listadas abaixo: O arquivo PDF submetido no repositório deve conter ficha catalográfica e certificado de aprovação (documentos obrigatórios). Favor inserir os mesmos no arquivo PDF e fazer novamente a submissão. Agradecemos a compreensão. o

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8

Mastrandrea, Nicholas Joseph. "Pentoxifylline As An Adjuvant Treatment In Renal Cell Carcinoma." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337293.

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Cyclin D1, a proto-oncogene, is required for progression from the G1 phase into the S phase of the cell cycle. Over-expression of cyclin D1 causes an increase in cell cycle progression and cell proliferation, implicating it in a variety of cancers including renal cell carcinoma (RCC). The rodent RCC cell model, QTRRE, and human RCC cell models, ACHN, 786-O and Caki-2, exhibit elevated levels of cyclin D1. Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, is an FDA-approved hemorheologic agent used to treat intermittent claudication, stemming from peripheral vascular diseases, a

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Marucha, Kevin [Verfasser], and Christine [Akademischer Betreuer] Clayton. "The suppressive role of 4EIP and PUF3 in gene expression during differentiation of Trypanosoma brucei / Kevin Marucha ; Betreuer: Christine Clayton." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1177045559/34.

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Tang, Yubo. "Traditional Chinese Medicine extracts exert angiogenic and protective effects towards human endothelial progenitor cells: from cellular function to molecular pathway." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144400.

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Despite intense research efforts, the repair of large bone defects is still not satisfactory and remains a major challenge in Orthopaedic Surgery. In this context bone tissue engineering has emerged as a promising strategy. However, one of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Thus an active blood vessel network is an essential pre-requisite for scaffold constructs to integrate within existing host tissue. Currently, great efforts are made to address this problem employing

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Espinoza, Madrid Paul Augusto. "Valoración de la expresión inmunohistoquímica en microarrays tisulares de RACK1, 4ebp1, p53 y Ki-67 en tumores colorrectales con correlación clínico patológica." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/385731.

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El estudio histopatológico del carcinoma colorectal tiene dos funciones: el diagnóstico y la búsqueda de parámetros morfológicos y biológicos que permitan presagiar la evolución clínica y/o la respuesta al tratamiento, en un enfermo particular, es decir, los llamados factores pronósticos y predictivos. Las características clínico patológicas clásicas siguen siendo los mejores factores pronósticos en el comportamiento de la neoplasia colorrectal, sin embargo, es fundamental la incorporación de nuevos biomarcadores en el análisis rutinario una vez comprobada su utilidad clínicopatológica. El gra

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Jenkins, Paul A. "Importance sampling on the coalescent with recombination." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:de04e3ae-d3be-4eb3-9045-2387d872283d.

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Performing inference on contemporary samples of homologous DNA sequence data is an important task. By assuming a stochastic model for ancestry, one can make full use of observed data by sampling from the distribution of genealogies conditional upon the sample configuration. A natural such model is Kingman's coalescent, with numerous extensions to account for additional biological phenomena. However, in this model the distribution of interest cannot be written down analytically, and so one solution is to utilize importance sampling. In this context, importance sampling (IS) simulates genealogie

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Sampson, Margaret Joan. "Updating searches for systematic reviews." Thesis, Aberystwyth University, 2009. http://hdl.handle.net/2160/c64afc7e-bf86-4eba-a421-9188804870c8.

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Introduction: This thesis examines methods for updating searches for systematic reviews of healthcare interventions. Systematic reviews endeavour to find and synthesize all relevant research as a basis for the practice of evidence-based medicine. They are more useful if they are complete and up-to-date. Materials and Methods: The sample was 93 meta-analyses in allopathic medicine. Newer randomized controlled trials (RCTs) were sought through MEDLINE searches, and were assessed for relevance by physicians. Two Boolean searches, two similarity searches and one non-database search approach were t

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Tiddeman, Megan. "Money talks : Anglo-Norman, Italian and English language contact in medieval merchant documents, c1200-c1450." Thesis, Aberystwyth University, 2017. http://hdl.handle.net/2160/6a2ed39e-68e7-4eb6-bdb5-c08658ee4a92.

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Current evidence for Anglo-Italian contact prior to 1500 is very rare and the major historical dictionaries contain only a handful of borrowings in either direction. This is in stark contrast to the huge amounts of evidence gathered for language contact between Continental French and Italian prior to 1500 and between English and Italian from 1500 onwards. However, Italians permeated many levels of English medieval society, including the top echelons of the royal Wardrobe and government Mints, London livery companies, wool-producing estate from the Cotswolds to Yorkshire and communities in majo

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Vellender, Adam. "Mathematical modelling of crack problems in bi-material structures containing imperfect interfaces using the weight function technique." Thesis, Aberystwyth University, 2013. http://hdl.handle.net/2160/84f836a0-8654-4ebf-a956-c28509aad4a9.

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The main aim of this thesis is to generalise weight function techniques to tackle crack problems in bi-material linearly elastic and isotropic solids with imperfect interfaces. Our approach makes extensive use of weight functions which are special solutions to homogeneous boundary value problems that aid in the evaluation of constants in asymptotic expressions describing the behaviour of physical fields near crack tips. We use newly derived weight functions and respective techniques to tackle various aspects of a number of problems. The first major application is the use of the new weight func

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Wilkinson, Toby. "Diversity of microsporidia infecting gammarid amphipods." Thesis, Aberystwyth University, 2010. http://hdl.handle.net/2160/128ade99-3a3b-4ebf-bef9-f46a2936d384.

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Perry, Sarah Louise. "Developing productive habitat models of megafauna distribution in the Irish Sea using multiple source sightings data." Thesis, Aberystwyth University, 2017. http://hdl.handle.net/2160/d7d3da18-3d46-4eb7-813f-83aa750c4963.

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Until recently monitoring of the marine environment and its megafauna population relied on field observations and catch or strandings information. However, new approaches are being developed which take into consideration the need for information over whole sea areas over wide spatial and temporal scales for the purposes of marine spatial planning and ecological research. This thesis investigates the use of wide scale predictive species distribution modelling using multiple source sightings information combined with environmental variable data for monitoring marine megafauna. The development of

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18

Daffern, Megan I. J. "Prayers for remembering in the Psalms." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b9f845c8-c271-4eb6-8a3c-e9acf75929f1.

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The Hebrew language of remembering is complex and theologically interesting. The effective, relational, actualising aspects of zkr are particularly evident in language of prayer, especially in Psalm texts. Prayer is a remembering of God, a reminding of God, and a call to remember the pray-er herself, and such performative illocutions are addressed to both human and divine audience alike. The texts become not only present acts of remembering, but also means by which future acts of remembering are to be performed. Questions in Psalms criticism, of public or private Sitz-im-Leben, of form classif

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Viriyasitavat, Wattana. "A framework of trust in service workflows." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:a894bd9c-eaf2-4ebd-91c1-35012cd0a527.

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The everything as a service concept enables dynamic resource provisions to be seen and delivered as services. Their proliferation nowadays leads to the creation of new value-added services composed of several sub-services in a pre-specified manner, known as service workflows. The use of service workflow appears in various domains, ranging from the basic interactions found in several e-commerce and several online interactions to the complex ones such as Virtual Organizations, Grids, and Cloud Computing. However, the dynamic nature in open environments makes a workflow constantly changing, to be

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Power, Lucy A. "e-Research in the life sciences : from invisible to virtual colleges." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:de32d659-8908-4ebe-ab50-3ba6330f456a.

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e-Research in the Life Sciences examines the use of online tools in the life sciences and finds that their use has significant impact, namely the formation of a Scientific/Intellectual Movement (SIM) (Frickel & Gross, 2005) complemented by a Computerisation Movement (CM) (Kling & Iacono, 1994) which is mobilising global electronic resources to form visible colleges of life science researchers, who are enrolling others and successfully promoting their open science goals via mainstream scientific literature. Those within this movement are also using these online tools to change their work practi

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Nasilowska, Agata. "The role of the CtIP gene as a genetic susceptibility factor for radiation leukaemogenesis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b8cc6940-e780-4ebd-8bf5-a655a52570d2.

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Exposure to ionising radiation increases the risk of cancer, including acute myeloid leukemia (AML), which is the most common myeloid leukaemia. The C-terminal binding protein (CtBP)-interacting protein (CtIP), which is essential for embryonic development and possibly functions as a tumour suppressor, has been identified as a strong candidate for susceptibility to radiation-induced AML (rAML).

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Lee, David Tsu-Long. "Behaviour of corrosion-protection coatings in light alloys." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:bfbcec97-5f42-4eb3-aaec-ba5443e953ba.

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Anionic chromate (VI) compounds are inhibitive pigments and have been effectively incorporated into organic coatings to protect metal surfaces from aggressive ions, but their risk as a human carcinogen and being harmful to the environment has led to the search of suitable alternatives. Aluminium alloy, AA2024-T3, is the substrate metal alloy used in the experiments and can be found in aircraft fuselage structures due to their high strength-to-weight ratio. However, the presence of intermetallic particles increases susceptibility to localised corrosion. To investigate the protection mechanisms

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Derry, Philip. "Quasiparticle interference in strongly correlated electronic systems." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:f487c821-dbbb-4ebe-8b05-c13807379c2c.

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We investigate the manifestation of strong electronic correlations in the quasiparticle interference (QPI), arising from the scattering of conduction electrons from defects and impurities in an otherwise translationally-invariant host. The QPI may be measured experimentally as the Fourier transform of the spatial modulations in the host surface density of states that result, which are mapped using a scanning tunnelling microscope. We calculate the QPI for a range of physically relevant models, demonstrating the effect of strong local electronic correlations arising in systems of magnetic impur

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Aird, Christopher John. "The influence of long-range residual stress on the cleavage fracture of ferritic steel." Thesis, University of Bristol, 2010. http://hdl.handle.net/1983/518cc704-b7bd-4ebf-a063-6cdcede108b9.

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This dissertation considers the influence of long-range residual stress on the cleavagefracture of ferritic steel. The existing body of work related to the influence ofmacro scale residual stress on fracture is reviewed. It is shown that although long-rangeresidual stress, resulting from misfits between components of an engineeringstructure, was discussed by a number of researchers in the late 1970s, it wasneither treated comprehensively nor developed by more recent researchers. Consequently, the design of a test rig capable of generating long-range residual stressin a laboratory compact-tensi

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Jokela, Juha. "The Europeanisation of foreign and security policy and the re-production of state identities in Finland and Britain." Thesis, University of Bristol, 2005. http://hdl.handle.net/1983/21d3af52-bd0d-4eb8-87e2-51f74ff89e43.

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Hillard, Peter John. "Aspects of the biomechanics of Ilizarov external fixation." Thesis, University of Bristol, 1999. http://hdl.handle.net/1983/9934ff7c-a0fc-4eb4-a2ab-323c07024660.

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The original Ilizarov frame is a form of circular external fixation in which bone fragments are supported by tensioned fine wires; the wires give the frame a nonlinear axial stiffness which is one of its key qualities. However, as the wires deform plastically in response to loads imposed by functional weight bearing, the stiffness of frame gradually decreases with time. To circumvent this problem the modified Ilizarov frame was conceived in which half pins rather than wires are used for bone support. As fractures managed with Ilizarov fixation tend to unite with little radiographic evidence, m

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27

Palti, Gilda. "A study of the socio-emotional aspects of educationally resilient dyslexic pupils." Thesis, University of Bristol, 1998. http://hdl.handle.net/1983/c298c4c9-4d9c-4eb5-9865-5de823eb3aa2.

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Razali, Siti Katizah. "Women in educational management in Sarawak : a study of traditional and professional challenges." Thesis, University of Bristol, 1998. http://hdl.handle.net/1983/07df9f34-8dbb-4eb1-8e71-12c865c14a68.

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This exploratory study examined how women managers in education in Sarawak combine their traditional and professional roles and deal with potential role conflict. The study is set in the context of an increasing number of women managers in education in Sarawak and the issues this raises for their support, if they are to harmonise their roles and advance professionally. The aim of the study is to furnish policy makers at the national and state level with information to formulate a policy document which could be adopted in preparing a strategy for the advancement of women managers, taking into a

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Anastasatou, Marianthi. "Essays on growth, financial markets, competition and inequality." Thesis, University of Bristol, 2009. http://hdl.handle.net/1983/f7b9526f-4900-4eb1-a7bd-fd718daa06e8.

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This thesis is broadly involved with growth economics. It starts with a theoretical analysis of the relation between credit markets and economic growth. It considers an exogenous production function model with risky investment projects in which a borrower's (an investor's) risk type is private information. This asymmetry induces lenders to offer loan contracts which separate borrowers as to type. Self-selection can be induced by credit rationing or a screening mechanism which allows lenders to acquire information about a borrower's type. Screening is assumed to be imperfect in the sense that l

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O'Sullivan, Dominic. "The effect of implant geometry upon the primary stability of dental implants." Thesis, University of Bristol, 2001. http://hdl.handle.net/1983/339010c1-63ee-4eb9-b03c-b3a2b9b89dbf.

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Nagashima, Jundo. "A study of the late Madhyamaka doxography." Thesis, University of Bristol, 2002. http://hdl.handle.net/1983/bdbe0308-340b-4ebc-9a5b-73c360818fb0.

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Brooks, Christopher John. "The foraging behaviour of Burchell's zebra (Equus burchelli antiquorum)." Thesis, University of Bristol, 2005. http://hdl.handle.net/1983/9dac90e0-80f4-4ebf-91d3-a43befc3255b.

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Casey, Briege. "Making an exhibition of ourselves : using narrative and arts-based inquiry with student nurses." Thesis, University of Bristol, 2010. http://hdl.handle.net/1983/e0235c18-2782-4ebf-b762-450551267125.

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Drong, Alexander Werner. "Comprehensive assessment of the role of DNA methylation in obesity and type 2 diabetes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c2df87d9-9929-4eb1-8c44-61452b88ea3c.

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Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular and other diseases and are currently undergoing an increase in global prevalence. The work presented in my thesis addresses the role epigenetics, specifically DNA methylation, plays in the susceptibility to obesity and T2D and deals with methodological issues in the analysis of DNA methylation data. I first combined epigenome-wide DNA methylation data across 38 adipose tissue samples with corresponding SNP and mRNA data for the same subjects. At 5&percnt; false discovery rate (FDR), methylation of 149 regions associate

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Boukouvala, Sotiria. "Expression of the genes for arylamine N-acetyltransferases in mice." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:ed864a10-2cb9-4ebe-8a2c-934d707c5a0d.

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Kapitan, Daniel. "Laser ablation with copper vapour lasers." Thesis, University of Oxford, 1999. https://ora.ox.ac.uk/objects/uuid:a1dc1a3b-602a-4ebb-abe2-734e8e11f15a.

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The use of copper vapour lasers for laser ablation in laser materials processing applications is studied. To this purpose, the generation of near diffraction-limited beam quality output from a single medium-scale oscillator is demonstrated via matching the total buffer gas pressure to the specific electrical input power loading and the degree of insulation of the plasma tube. The design and characterisation of a Master-Oscillator Power-Amplifier system based on a smallbore oscillator is also described, focusing on pulse stretching techniques to provide efficient seeding required for producing

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Martin, Itziar Serna. "Study of the structure and function of the influenza virus RNA-dependent RNA polymerase." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b1f808d4-4ad4-4eb4-bbe8-c2019263d45a.

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Influenza viruses are segmented, negative-sense RNA viruses responsible for influenza disease. Unlike other negative-sense RNA viruses, influenza virus genome replication occurs in the nucleus of infected cells. The virus encodes a heterotrimeric RNA-dependent RNA polymerase (FluPol) that is responsible for transcribing and replicating the viral genome. In order to transcribe, the FluPol generates capped RNA primers by a process termed 'cap-snatching'. In it, the polymerase binds host capped RNAs and cleaves them 10-13 nucleotides downstream of the cap structure. The catalytic core of FluPol i

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Hronesova, Jessie. "Salience, authority, and resources : explaining victims' compensation in postwar Bosnia and Herzegovina." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:dd26cfd4-9887-4ebf-9831-98c0fdd324d5.

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The aim of this thesis is to probe subnational varieties in compensation enacted for war victims in post-war Bosnia and Herzegovina. The current literature in transitional justice posits that mainly the nature of previous conflicts, democratic and economic development, international normative pressures, and the regional clustering of justice explain why only some post-war countries award material assistance to victims (Olsen et al. 2010; Kim 2012; Risse and Sikkink 2013; Powers and Proctor 2015). While these explanations provide critical insights into the processes behind compensation adoption

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Kearney, Jillian. "Donne's Devotions in the context of his early sermons : a revelation of St. John the Divine." Thesis, University of Oxford, 1995. https://ora.ox.ac.uk/objects/uuid:1c24978b-40cc-4eb1-a009-0ca0201b7d9c.

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This thesis explores the relationship between Donne's Devotions Upon Emergent Occasions (1623) and his early sermons. Its underlying contention is the existence in the Devotions of a highly organized, thematic structure, which not only focusses major concerns scattered through the sermons, but places them in typological relation. Chapters 1-4 concentrate on Donne's discussion of these concerns in the sermons; Chapter 5 then demonstrates their recognizable convergence in the Devotions to trace an evolving narrative. Chapter 1 begins with beginnings, and Donne's obsessive pursuit of the origin t

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Chung, Jennifer. "An investigation of reasons for Finland's success in PISA." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:62b7a22f-d930-4eb0-893d-d703fd9d182d.

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The Programme for International Student Assessment, or PISA, administered by the Organisation for Economic Cooperation and Development, surveyed fifteen-year-olds for the first time in 2000. PISA focuses on mathematics, science, and reading literacy, and intends to undertake a new study every three years. The administration in 2003 added a section that measured problem-solving skills. The results from all three surveys thus far have placed Finland as the highest achieving country in PISA. Finland’s top performances in PISA astonished the educational world. More so than previous cross-national

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Brehony, Carina. "The temporal and geographical distribution and diversity of disease-associated Neisseria meningitidis genetic types in Europe." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:78a6afcc-4eb4-49fc-9d06-4cb36ddb8156.

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Meningococcal disease, caused by the bacterium Neisseria meningitidis, is an important cause of morbidity and mortality in young children and adolescents worldwide. There are 12 serogroups with most disease due to meningococci expressing one of five capsular polysaccharide antigens corresponding to serogroups A, B, C, Y and W135. In Europe, the majority of disease-causing strains are of serogroups B and C. No comprehensive vaccine is available against the bacterium due to the difficulty in producing serogroup B vaccines. A number of countries, e.g. UK and the Republic of Ireland have implement

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Yee, Margaret May. "The validity of theology as an academic discipline : a study in the light of the history and philosophy of science and with special reference to relevant aspects of the thought of Austin Farrer." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:2045ddd1-056a-4eb9-830c-cd26f51fbb00.

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An analysis of relevant aspects of the history of science shows that theology's loss of credibility in an increasingly science-oriented age can be attributed to unresolved disputes from the past over metaphysical, epistemological and methodological issues. In Chapters 1 and 2, an attempt is made to show that the basic disagreements between science and theology can be traced to the ongoing quest for the principles of knowing shared by all disciplines. In Chapters 3 to 6, an attempt is made to identify these principles. Firstly, the processes and principles by which science acquires its knowledg

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Wade, R. C. "Ligand-macromolecule interactions." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:576ce119-6a93-4eb0-a7e4-1f2513736dbd.

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The optimisation of ligand-macromolecule interactions is fundamental to the design of therapeutic agents. The GRID method is a procedure for determining energetically favourable ligand binding sites on molecules of known structure using an empirical energy potential. In this thesis, it has been extended, tested, and then applied to the design of anti-influenza agents. In the GRID method, the energy of a hydrogen-bond is determined by a function which is dependent on the length of the hydrogen-bond, its orientation at the hydrogen-bond donor and acceptor atoms, and the chemical nature of these

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Camfield, Laura. "Measuring quality of life in dystonia : an ethnography of contested representations." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:6ac544f6-41a9-4eb6-8dda-9b7325ec1611.

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This thesis examines the experiences of people living with dystonia1 and the ways these are represented by people living with dystonia, the Dystonia Society, neurologists, quality of life (QOL) researchers and pharmaceutical companies. Drawing on ethnographic fieldwork conducted within the Dystonia Society and on projects developing a disease-specific QOL measure, and investigating the impact of dystonia on people’s QOL, the thesis explores a series of questions about the conceptual and practical problems inherent in such measures. It asks: • How dystonia is defined and represented and its imp

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Hartwell, Marcia Byrom. "Perceptions of justice, identity, and political processes of forgiveness and revenge in early post-conflict transitions : case studies, Northern Ireland, Serbia, South Africa." Thesis, University of Oxford, 2005. http://ora.ox.ac.uk/objects/uuid:64cd9d6e-c557-4eb5-ac2e-cfaca04d7bf6.

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Genolini, Pietro Benetti. "Precision holography and supersymmetric theories on curved spaces." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:8526cac1-07a1-4ebc-bde0-f75debf58eda.

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The formulation of rigid supersymmetric field theories on curved space leads to a number of results on their strongly-interacting regime, crucial from both the mathematical and physical point of view, starting from Witten's topological twist of four-dimensional Yang-Mills theory. At the same time, strongly-coupled field theories may also be studied holographically via the AdS/CFT correspondence. The aim of this thesis is to study aspects of the holographic dictionary for supersymmetric theories on curved manifolds. A key aspect of the correspondence is the renormalization of gravity observable

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Taylor, Jamie M. "Mathematical models of liquid crystals and related materials." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:37bea5e7-889d-4eb1-986d-52f869d7f4b8.

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In the broadest sense, the focus of this thesis concerns the role of entropy in macroscopic systems related to liquid crystals in equilibrium. We be- gin by defining a broad generalisation of the Ball-Majumdar potential, applicable to a wide variety of order parameter models relevant to liquid crystals. First we provide a geometric characterisation of the set of ad- missible order parameters for general systems. We demonstrate the key properties of convexity, regularity, and blow up at the boundary of the singular potential. This is then followed by a discussion of applications to Onsager type

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Le, Ngoc Phuong Lan. "Roles of quaternary architectures in immunoglobulin glycosylation and antibody-based therapeutics." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:83c96b02-3372-4eb0-b02f-a31b3f425867.

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Immunoglobulins play a key role in humoral immunity and have emerged as an important class of biotherapeutics. While the IgG1 backbone tends to be the conventional choice in these recombinant therapies, several therapeutics that focus on other immunoglobulin isotypes are being developed. With the exception of IgA Fc, the conserved glycan of IgD, IgM, IgG and IgE projects across the surface of an immunoglobulin domain with the two opposing glycans packing within the homodimeric Fc structure. This apparent similarity in structure is largely reflected in shared glycosylation status with most clas

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Wood, Christopher. "Oxidative stress and seed survival." Thesis, Abertay University, 1998. https://rke.abertay.ac.uk/en/studentTheses/79d28b74-9210-4ebd-a3b8-66a610bd8c87.

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Free radical and aldehydic breakdown product content were determined, by EPR and UV / visible spectroscopy, primarily in intermediate (desiccation tolerant) seeds of <i>Carica papaya</i> L. (Papaya) and recalcitrant (desiccation intolerant) seeds of <i>Aesculus hippocastanum</i> L. (Horse chestnut), but also in other species covering a range of desiccation tolerances, with a view to determining the role of oxidative stress as a diagnostic marker for desiccation tolerance. Axes of non-senescent highly viable recalcitrant seeds of horse chestnut were metabolically active, contained products of l

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Cox, Peter John. "The effects of a novel substrate on exercise energetics in elite athletes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7aa52ece-42e1-4ebc-ba1c-727ba1f95cb8.

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The physiological ketosis of starvation makes sound evolutionary sense, as ketone bodies have several thermodynamic advantages over other nutritional substrates, in addition to their actions to conserve protein and glucose stores. Utilising the body’s metabolic responses to ketosis by delivering a novel nutritional source of ketone bodies, the work in this thesis explored the metabolic effects of ketosis on physical performance in humans. First, the pharmacokinetics and dosing requirements for ketone containing drink preparations were characterised in a population of athletes and healthy contr

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