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Journal articles on the topic '5-a]pyrimidine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur

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2

Ossipov, D., E. Zamaratski, and J. Chattopadhyaya. "The 5′-Purine-Pyrimidine-3′ Stacks are More Stabilizing in a Self-3′-Pyrinudine-Purine-5′ complementary DNA Duplex than the 5′-Purine-Purine-3′ 3′-Pyrimidine-Pyrimidine-5′ Stack." Nucleosides and Nucleotides 17, no. 9-11 (1998): 1613–16. http://dx.doi.org/10.1080/07328319808004693.

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3

Zerez, Charles R., and Kouichi R. Tanaka. "A continuous spectrophotometric assay for pyrimidine-5′-nucleotidase." Analytical Biochemistry 151, no. 2 (1985): 282–85. http://dx.doi.org/10.1016/0003-2697(85)90176-9.

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4

Shanmugasundaram, Muthian, Annamalai Senthilvelan, and Anilkumar R. Kore. "C-5 Substituted Pyrimidine Nucleotides/Nucleosides: Recent Progress in Synthesis, Functionalization, and Applications." Current Organic Chemistry 23, no. 13 (2019): 1439–68. http://dx.doi.org/10.2174/1385272823666190809124310.

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The chemistry of C5 substituted pyrimidine nucleotide serves as a versatile molecular biology probe for the incorporation of DNA/RNA that has been involved in various molecular biology applications such as gene expression, chromosome, and mRNA fluorescence in situ hybridization (FISH) experiment, mutation detection on arrays and microarrays, in situ RT-PCR, and PCR. In addition to C5 substituted pyrimidine nucleotide, C5 substituted pyrimidine nucleoside displays a broad spectrum of biological applications such as antibacterial, antiviral and anticancer activities. This review focusses on the

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5

Huppatz, JL. "Systemic Fungicides. The Synthesis of Pyrazolo[1,5-a]pyrimidine Analogues of Carboxin." Australian Journal of Chemistry 38, no. 1 (1985): 221. http://dx.doi.org/10.1071/ch9850221.

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The synthesis of a series of pyrazolo [1,5-a] pyrimidine derivatives, structural analogues of the systemic fungicide carboxin, is described. A common intermediate incorporating structural features desirable for fungicidal activity, N-phenyl-3(5)-amino-5(3)-methylpyrazole-4- carboxamide (6), was used to prepare pyrazolo [1,5-a] pyrimidines variously substituted in positions 5 and 7 of the ring system. Bromination of N-phenyl-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide (8) occurred preferentially in the phenyl ring and the 6-bromo derivative was prepared by bromination of the corresponding 3

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6

Yakovlev, Dmitry S., Pavel M. Vassiliev, Yana V. Agatsarskaya, et al. "Searching for novel antagonists of adenosine A1 receptors among azolo[1,5-a]pyrimidine nitro derivatives." Research Results in Pharmacology 8, no. (2) (2022): 69–75. https://doi.org/10.3897/rrpharmacology.8.77854.

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Introduction: Ligands of adenosine A<sub>1</sub>Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At the same time, there is a deficiency of drugs that can regulate the functions of A<sub>1</sub> receptors. A number of A<sub>1</sub>-antagonists are at the various stages of clinical trials; other drugs are not very selective or are characterized by an insufficient breadth of their therapeutic action. Therefore, the search for

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7

V. VOSTRIKOVA, Tatiana, Vladislav N. KALAEV, Andrey Yu POTAPOV, Dmitry Y. VANDYSHEV, and Khidmet S. SHIKHALIEV. "USING SYNTHESISED ORGANIC COMPOUNDS AS ENVIRONMENTALLY FRIENDLY RETARDANTS FOR ORNAMENTAL PLANTS." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 28, no. 28 (2020): 40–44. http://dx.doi.org/10.48141/sbjchem.v28.n28.2020.06_vostrikova_pgs_40_44.pdf.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2-piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gre

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8

Vostrikova, Tatiana, Vladislav Kalaev, Andrey Potapov, Dmitry Vandyshev, and Khidmet Shikhaliev. "Using Synthesised Organic Compounds as Environmentally Friendly Retardants for Ornamental Plants." Southern Brazilian Journal of Chemistry 28, no. 28 (2020): 40–44. http://dx.doi.org/10.37633/sbjc.28(28)2020.40-44.

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The pre-sowing treatment of scarlet sage (Salvia splendens Ker Gawl.) seeds with 4-methyl-2-piperidin1-yl-pyrimidine-5-carboxylic acid at concentrations of 0.01, 0.05, and 0.1% proved to have an obvious inhibiting effect. Prior to sowing, the seeds of Salvia splendens were soaked in a water suspension of 4-methyl-2- piperidin-1-yl-pyrimidine-5-carboxylic acid and 4-methyl-2-morpholin-4-pyrimidine-5-carboxylic acid with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. On the 42nd day of the experiment, the seedlings, having been preliminarily hardened for 12 days, were removed from the gr

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9

Dorn, Helmut, and Alfred Zubek. "Pyrazolo [1, 5-a]pyrimidine aus 3 (5)-Amino-pyrazol und Acetessigester." Zeitschrift für Chemie 7, no. 9 (2010): 343. http://dx.doi.org/10.1002/zfch.19670070908.

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10

Dragon, Stefanie, Rainer Hille, Robert Götz, and Rosemarie Baumann. "Adenosine 3′:5′-Cyclic Monophosphate (cAMP)-Inducible Pyrimidine 5′-Nucleotidase and Pyrimidine Nucleotide Metabolism of Chick Embryonic Erythrocytes." Blood 91, no. 8 (1998): 3052–58. http://dx.doi.org/10.1182/blood.v91.8.3052.3052_3052_3058.

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Terminally differentiating erythrocytes degrade most of their RNA with subsequent release of mononucleotides. Pyrimidine mononucleotides are preferentially cleaved by an erythrocyte-specific pyrimidine 5′-nucleotidase; deficiency of this enzyme causes hemolytic anemia in humans. Details of the regulation of its activity during erythroid differentiation are unknown. The present study arose from the observation that the immature red blood cells (RBCs) of mid-term chick embryos contain high concentrations of uridine 5′-triphosphate (UTP) (5 to 6 mmol/L), which decline rapidly from days 13 to 14 o

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11

Altounian, Lucille, Julien Perrin, Fanny Fouyssac, et al. "Pyrimidine 5’-nucleotidase deficiency associated to a polymalformative syndrome." Annales de biologie clinique 73, no. 5 (2015): 587–90. http://dx.doi.org/10.1684/abc.2015.1078.

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12

Gimadieva, A. R., V. A. Myshkin, A. G. Mustafin, et al. "5-amino-6-methyluracil is a promising pyrimidine antioxidant." Doklady Biological Sciences 448, no. 1 (2013): 7–9. http://dx.doi.org/10.1134/s0012496613010110.

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13

Bassoude, Ibtissam, Sabine Berteina-Raboin, El Mokhtar Essassi, Gérald Guillaumet, and Lahcen El Ammari. "7-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine." Acta Crystallographica Section E Structure Reports Online 69, no. 5 (2013): o749. http://dx.doi.org/10.1107/s1600536813009896.

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14

Fettouhi, M., A. Boukhari, B. El Otmani, and E. M. Essassi. "7-Ethoxycarbonylmethyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine." Acta Crystallographica Section C Crystal Structure Communications 52, no. 4 (1996): 1031–32. http://dx.doi.org/10.1107/s0108270195013680.

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15

Samanta, Anirban, Swagata Dasgupta, and Tanmaya Pathak. "5′-Modified pyrimidine nucleosides as inhibitors of ribonuclease A." Bioorganic & Medicinal Chemistry 19, no. 7 (2011): 2478–84. http://dx.doi.org/10.1016/j.bmc.2010.08.059.

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16

Lokaj, Jan, Viktor Kettmann, Svetozár Katuščák, Petra Černuchová, Viktor Milata, and Fridrich Gregáň. "5-Methyl-1,2,4-triazolo[1,5-a]pyrimidine-6-carbonitrile." Acta Crystallographica Section E Structure Reports Online 62, no. 4 (2006): o1252—o1253. http://dx.doi.org/10.1107/s1600536806007240.

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The title compound, C7H5N5, was designed and synthesized as a potential antitumour agent. The molecules are located on crystallographic mirror planes. The electron-accepting 6-cyano group has no effect on the π-electron cloud of the heterocyclic system. The molecular packing is governed by C—H...N intermolecular hydrogen bonds, which link the molecules into chains running along the c axis.

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17

Vicentes, Daniel E., Ricaurte Rodríguez, Patricia Ochoa, Justo Cobo, and Christopher Glidewell. "A concise and efficient synthesis of amino-substituted (1H-benzo[d]imidazol-1-yl)pyrimidine hybrids: synthetic sequence and the molecular and supramolecular structures of six examples." Acta Crystallographica Section C Structural Chemistry 75, no. 10 (2019): 1405–16. http://dx.doi.org/10.1107/s2053229619012087.

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A concise and efficient synthesis of a series of amino-substituted benzimidazole–pyrimidine hybrids has been developed, starting from the readily available N 4-(2-aminophenyl)-6-methoxy-5-nitrosopyrimidine-2,4-diamine. In each of N 5-benzyl-6-methoxy-4-(2-phenyl-1H-benzo[d]imidazol-1-yl)pyrimidine-2,5-diamine, C25H22N6O, (I), 6-methoxy-N 5-(4-methoxybenzyl)-4-[2-(4-methoxyphenyl)-1H-benzo[d]imidazol-1-yl]pyrimidine-2,5-diamine, C27H26N6O3, (III), 6-methoxy-N 5-(4-nitrobenzyl)-4-[2-(4-nitrophenyl)-1H-benzo[d]imidazol-1-yl]pyrimidine-2,5-diamine, C25H20N8O5, (IV), the molecules are linked into t

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18

Kalluraya, Balakrishna, Sharatha Kumar, and Priya. "Synthesis and SAR Studies of Some Novel Series of Pyrimidine Analogues." Asian Journal of Chemistry 36, no. 10 (2024): 2397–404. http://dx.doi.org/10.14233/ajchem.2024.32345.

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A series of novel ethyl-4-methyl-6-phenyl-2-(substituted thio)pyrimidine-5-carboxylate (4a-m), ethyl-4-methyl-phenyl-2-(substituted sulfinyl)pyrimidine-5-carboxylate (5a-m) and ethyl-4-methyl-phenyl-2-(substituted sulfonyl)pyrimidine-5-carboxylate (6a-m) were synthesized by multi-step organic synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, LCMS and elemental analysis. Most of the compounds showed significant antibacterial and anticancer activity comparable to or higher than the standard employed.

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19

McNeil, J. B. "Functional characterization of a pyrimidine-rich element in the 5'-noncoding region of the yeast iso-1-cytochrome c gene." Molecular and Cellular Biology 8, no. 3 (1988): 1045–54. http://dx.doi.org/10.1128/mcb.8.3.1045-1054.1988.

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A predominantly pyrimidine-rich sequence (purine in the template strand, 32 of 37 bases) is located between a functional TATA element and the corresponding transcription start site region of the Saccharomyces cerevisiae iso-1-cytochrome c (CYC1) gene. By using linker deletions and gene fusion techniques, the functional characteristics of this pyrimidine sequence were examined. Results indicate that the function of this element is to limit the accumulation of full-length mRNAs with 5' ends which map upstream of the pyrimidine-rich sequence. Data suggest that the 5'-noncoding region of the CYC1

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20

McNeil, J. B. "Functional characterization of a pyrimidine-rich element in the 5'-noncoding region of the yeast iso-1-cytochrome c gene." Molecular and Cellular Biology 8, no. 3 (1988): 1045–54. http://dx.doi.org/10.1128/mcb.8.3.1045.

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A predominantly pyrimidine-rich sequence (purine in the template strand, 32 of 37 bases) is located between a functional TATA element and the corresponding transcription start site region of the Saccharomyces cerevisiae iso-1-cytochrome c (CYC1) gene. By using linker deletions and gene fusion techniques, the functional characteristics of this pyrimidine sequence were examined. Results indicate that the function of this element is to limit the accumulation of full-length mRNAs with 5' ends which map upstream of the pyrimidine-rich sequence. Data suggest that the 5'-noncoding region of the CYC1

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21

Sharma, M. C. "QSAR STUDIES ON PYRAZOLO [1, 5-A] PYRIMIDINE-BASED PIM-1 KINASE INHIBITORS." INDIAN DRUGS 53, no. 11 (2016): 12–19. http://dx.doi.org/10.53879/id.53.11.10594.

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Quantitative structure-activity relationships (QSAR) have been applied in order to explain the structural requirements of Pim-1 kinase activity of pyrazolo [1, 5-a] pyrimidine derivatives. The QSAR model was an internal predictive power (q2 = 0.7866) of 78% and a predictivity for the external test set (pred_r2 = 0.7742) of about 77%. The developed significant QSAR model indicates that HUMO energy, SsOHcount, SsNH2Count and T_O_O_4 potential of whole molecule play an important role in Pim-1 kinase inhibitor of pyrimidine. Consequently, these results can be useful in identifying the structural r

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22

West, Thomas P. "Regulation of pyrimidine formation in Pseudomonas lundensis." Canadian Journal of Microbiology 55, no. 3 (2009): 261–68. http://dx.doi.org/10.1139/w08-137.

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The regulation of pyrimidine formation in the food spoilage agent Pseudomonas lundensis ATCC 49968 by pyrimidines was examined. In P. lundensis cells grown on glucose as a carbon source, the enzymes aspartate transcarbamoylase, dihydroorotase, and orotidine 5′-monophosphate decarboxylase were induced by orotic acid. Pyrimidine auxotrophs containing reduced transcarbamoylase or orotate phosphoribosyltransferase activity were isolated using chemical mutagenesis and selection procedures. Independent of carbon source, the maximum derepression of enzyme activity was observed for orotidine 5′-monoph

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23

M., Sudha Swaraga, Charitha L., and Adinarayana M. "Photooxidation of substituted pyrimidines in presence of peroxydisulphate in aqueous solution." Journal of India Chemical Society Vol 81, Jul 2004 (2004): 579–83. https://doi.org/10.5281/zenodo.5830747.

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Department of Chemistry. Osmania University. Hyderabad-500 007, India <em>E-mail </em>: mundra_adinarayana@hotmail.com <em>Manuscript received 4 July 2003.accepted 5 February 2004</em> Photooxidation of pyrimidine bases viz. thymine, uracil, cytosine, 5-bromouracil and 6-methyluracil in presence of peroxydisulphate (PDS) in aqueous solution at natural pH (7.5) has been carried out in a quantum yield reactor using a high-pressure mercury lamp. The reaction between pyrimidine and \(SO_4^{\cdot-}\) is followed by mcasurin!( the absorbance of pyrimidine at its λ<sub>max<

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24

Nwachukwu, Chideraa I., Leanna J. Patton, Nathan P. Bowling, and Eric Bosch. "Ditopic halogen bonding with bipyrimidines and activated pyrimidines." Acta Crystallographica Section C Structural Chemistry 76, no. 5 (2020): 458–67. http://dx.doi.org/10.1107/s2053229620005082.

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The potential of pyrimidines to serve as ditopic halogen-bond acceptors is explored. The halogen-bonded cocrystals formed from solutions of either 5,5′-bipyrimidine (C8H6N4) or 1,2-bis(pyrimidin-5-yl)ethyne (C10H6N4) and 2 molar equivalents of 1,3-diiodotetrafluorobenzene (C6F4I2) have a 1:1 composition. Each pyrimidine moiety acts as a single halogen-bond acceptor and the bipyrimidines act as ditopic halogen-bond acceptors. In contrast, the activated pyrimidines 2- and 5-{[4-(dimethylamino)phenyl]ethynyl}pyrimidine (C14H13N3) are ditopic halogen-bond acceptors, and 1:1 halogen-bonded cocrysta

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25

Quesada, Antonio, Antonio Marchal, Manuel Melguizo, John N. Low, and Christopher Glidewell. "Symmetrically 4,6-disubstituted 2-aminopyrimidines and 2-amino-5-nitrosopyrimidines: interplay of molecular, molecular–electronic and supramolecular structures." Acta Crystallographica Section B Structural Science 60, no. 1 (2004): 76–89. http://dx.doi.org/10.1107/s0108768103024856.

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The structures of six symmetrically 4,6-disubstituted 2-aminopyrimidines, four of them containing a 5-nitroso substituent, have been determined. The nitroso compounds, in particular, exhibit polarized molecular–electronic structures leading to extensive charge-assisted hydrogen bonding. The intermolecular interactions observed include hard hydrogen bonds of N—H...N and N—H...O types together with O—H...O and O—H...N types in 2-amino-4,6-bis(2-hydroxyethylamino)-5-nitrosopyrimidine; soft hydrogen bonds of the C—H...O type in both 2-amino-4,6-bis(morpholino)-5-nitrosopyrimidine (3) and 2-amino-4

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26

Wolska, Irena, and Franciszek Herold. "Structural Investigation of Two 4-AryIhexahydro-1H,3H-pyrido[1,2-c]pyrimidine-1,3-diones." Zeitschrift für Naturforschung B 55, no. 11 (2000): 1089–94. http://dx.doi.org/10.1515/znb-2000-1116.

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The X-ray crystal structure determination of 4-(4'-fluorophenyl)hexahydro-1H,3H-pyrido[ 1,2-c]pyrimidine-1,3-dione (5) and 4-(4'-chlorophenyl)hexahydro-1H,3H-pyrido [1,2-c]- pyrimidine-1,3-dione (8) is reported. The crystal structures show the formation of centrosymmetric dimers via intermolecular N-H···O hydrogen bonds. The saturated ring adopts a slightly distorted sofa conformation both in 5 and in 8. In either compound the planar phenyl ring is twisted with respect to the pyrimidine-1,3-dione fragment.

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27

Kim, Juhyeon, Yoon Jung Kim, Ashwini M. Londhe, et al. "Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists." Molecules 24, no. 18 (2019): 3234. http://dx.doi.org/10.3390/molecules24183234.

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Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. To improve selectivity for 5-HT2C over other subtypes, we synthesized two series of disubstituted pyrimidines with fluorophenylalkoxy groups at either the 5-position or 4-position and varying cyclic amines at the 2-position. The in vitro cell-based assay and binding assay identified compounds 10a and 10f as potent 5-HT2C agonists. Further studies on selectivity to 5-HT subtypes and drug-like properties indicated that 2,4-disubstituted pyrimidine 10a showed a hig

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28

Jiang, Duo Hua, and Gang Liu. "Synthesis and Properties Study of 1-(2,4-Dimethoxyl-5-Pyrimidinyl)-2-[2-Methyl-5-(3-Cyano)-3-Thienyl]Perfluorocyclopentene." Applied Mechanics and Materials 662 (October 2014): 91–94. http://dx.doi.org/10.4028/www.scientific.net/amm.662.91.

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A novel photochromic diarylethene bearing a pyrimidine moiety, 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(3-cyano)-3-thieny-l] perfluorocyclopentene has been synthesized. Its properties, including photochromic behavior and fluorescent properties, have been investigated. The compound exhibited remarkable photochromism, changing from colorless to blue after irradiation with UV light. The results indicated that the pyrimidine moiety played a very important role during the process of photoisomerization reactions.

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29

Olaru, Alexandra M., Alister Burt, Peter J. Rayner, et al. "Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei." Chemical Communications 52, no. 100 (2016): 14482–85. http://dx.doi.org/10.1039/c6cc07109k.

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The hyperpolarisation of the <sup>119</sup>Sn and <sup>29</sup>Si nuclei in 5-(tributylstannyl)pyrimidine (A<sub>Sn</sub>) and 5-(trimethylsilyl)pyrimidine (B<sub>Si</sub>) is achieved through their reaction with [IrCl(COD)(IMes)] (1a) or [IrCl(COD)(SIMes)] (1b) and parahydrogen via the SABRE process.

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30

Xu, Jingli, Hang Liu, Guixia Li, and Chuanmin Qi. "7-Chloro-5-(chloromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1161. http://dx.doi.org/10.1107/s160053681201166x.

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All non-H atoms of the title compound, C8H4Cl2N4, are essentially coplanar, with an r.m.s. deviation of 0.011 Å. In the crystal, weak C—H...N hydrogen bonds link the molecules into infinite sheets parallel to thebcplane.

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31

Bassoude, Ibtissam, Sabine Berteina-Raboin, El Mokhtar Essassi, Gérald Guillaumet, and Lahcen El Ammari. "Ethyl 7-methyl-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate." Acta Crystallographica Section E Structure Reports Online 69, no. 5 (2013): o740. http://dx.doi.org/10.1107/s1600536813009902.

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32

Remennikov, Grigoriy Ya, Bernhard Kempf, Armin R. Ofial, Kurt Polborn, and Herbert Mayr. "5-Methoxyfuroxano[3,4-d]pyrimidine: a highly reactive neutral electrophile." Journal of Physical Organic Chemistry 16, no. 8 (2003): 431–37. http://dx.doi.org/10.1002/poc.606.

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33

Ren, Demin, Ye Tang, Xianyong Yu, Yulin Huang, and Xiaofang Li. "Synthesis of spiro[cyclopent-2/3-ene-1,2′-[1,3]thiazolo[3,2-a] pyrimidine] derivatives via 1,3-dipolar cycloaddition reaction of ethyl buta-2,3-dienoate." Journal of Chemical Research 42, no. 12 (2018): 631–35. http://dx.doi.org/10.3184/174751918x15426290490753.

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The 1,3-dipolar cycloaddition reaction of ethyl (2Z)-5-aryl-2-(2-methoxy-2-oxoethylidene)-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a] pyrimidine-6-carboxylate and ethyl buta-2,3-dienoate catalysed by triphenylphosphine afforded novel spiro[cyclopent-2-ene-1,2′-[1,3] thiazolo[3,2-a]pyrimidine] and spiro[cyclopent-3-ene-1,2′-[1,3]thiazolo[3,2-a]pyrimidine] derivatives in moderate yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS together with X-ray crystallographic analysis.

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34

Brzechwa-Chodzyńska, Anna, Mateusz Gołdyn, Anna Walczak, Jack M. Harrowfield, and Artur R. Stefankiewicz. "Hydrogen Bonding Directed Self-Assembly of a Binuclear Ag(I) Metallacycle into a 1D Supramolecular Polymer." Molecules 26, no. 18 (2021): 5719. http://dx.doi.org/10.3390/molecules26185719.

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An Ag(I) metallacycle obtained unexpectedly during the preparation of Pd(II) complexes of the bifunctional ligand 5-([2,2′-bipyridin]-5-yl)pyrimidine-2-amine (L) has been characterized using X-ray structure determination as a binuclear, metallacyclic species [Ag2L2](SbF6)2, where both the bipyridine and pyrimidine-N donors of L are involved in coordination to the metal. The full coordination environment of the Ag(I) defines a case of highly irregular 4-coordination. In the crystal, the Ag-metallacycles assemble into one-dimensional supramolecular metalladynamers linked together by hydrogen-bon

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35

Hashmi, Imran Ali, Holger Feist, Manfred Michalik, Helmut Reinke та Klaus Peseke. "Dimethylaminomethylene-α-D-xylo-hept-5-ulofuranurononitrile as Building Block in the Synthesis of ‘Reversed’ C-Nucleoside Analogues". Zeitschrift für Naturforschung B 61, № 3 (2006): 292–300. http://dx.doi.org/10.1515/znb-2006-0309.

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Abstract 3-O-Benzyl-6-deoxy-1,2-O-isopropylidene-6-(dimethylaminomethylene)-α-D-xylo-hept-5-ulofuranurononitrile (1) was reacted with amidinium salts, S-methylisothiouronium sulfate, and guanidinium chloride, respectively, in the presence of bases to furnish the 4-(3-O-benzyl-1,2-O-isopropylidene- α-D-xylo-tetrofuranos-4-yl)pyrimidine-5-carbonitriles 2 and the 4-(1,2-O-isopropylidene- α-D-glycero-tetr-3-enofuranos-4-yl)pyrimidine-5-carbonitriles 3, respectively. Treatment of 1 with ethyl 5-aminopyrazole-4-carboxylates yielded the ethyl 7-(3-O-benzyl-1,2-O-isopropylidene- α-D-xylo-tetrofuranos-

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36

Jakubowski, Mateusz, Iwona Łakomska, Adriana Kaszuba, Andrzej Wojtczak, Jerzy Sitkowski, and Andrzej A. Jarzęcki. "Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-a]pyrimidine Derivatives and Tetrahydrothiophene-1-Oxide or Diphenyl Sulfoxide." International Journal of Molecular Sciences 23, no. 7 (2022): 3656. http://dx.doi.org/10.3390/ijms23073656.

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The platinum(II) complexes of general formula [PtCl2(dstp)(S-donor)] were dstp 5,7-dimethyl-1,2,4-triazolo[1,5-a]-pyrimidine (dmtp), 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp), 5-methyl-7-isobutyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) or 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), whereas S-tetrahydrothio-phene-1-oxide (TMSO) or diphenyl sulfoxide (DPSO) were synthesized in a one-pot reaction. Here, we present experimental data (1H, 13C, 15N, 195Pt NMR, IR, X-ray) combined with density functional theory (DFT) computations to support and characterize structure–spectra rel

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Zeng, Qing, Demin Ren, Xingliang Fu, and Xiaofang Li. "Synthesis of Spiro[Pyrrolo[2,1-b][1,3]Benzothiazole-3,2′-[1,3]Thiazolo[3,2-a] Pyrimidine] via Cycloaddition Reactions." Journal of Chemical Research 42, no. 5 (2018): 260–63. http://dx.doi.org/10.3184/174751918x15260567362969.

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The 1,3-dipolar cycloaddition reaction of ethyl-5-aryl-2-[( Z)-2-methoxy-2-oxoethylidene]-7-methyl-3-oxo-3,5-dihydro-2 H-thiazolo[3,2- a] pyrimidine-6-carboxylates and azomethine ylide, which was generated in situ by the reaction of N-4-methoxyphenacylbenzothiazolium bromides and triethylamine, yielded novel 6′-ethyl-2-methyl-5′-aryl-1-(4-methoxybenzoyl)-7-methyl-3′-oxo-1,2-dihydro-5 H-spiro[pyrrolo[2,1- b][1,3]benzothiazole-3,2′-[1,3]thiazolo[3,2- a]pyrimidine]-2,6′-dicarboxylates in moderate yields. The structures of all of the products were characterised by NMR, IR, HRMS spectrometry, toget

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38

Chunduru, Jayendra, and Thomas P. West. "Pyrimidine nucleotide synthesis in the emerging pathogen Pseudomonas monteilii." Canadian Journal of Microbiology 64, no. 6 (2018): 432–38. http://dx.doi.org/10.1139/cjm-2018-0015.

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Regulation of pyrimidine biosynthesis by pyrimidines in the emerging, opportunistic human pathogen Pseudomonas monteilii ATCC 700476 was evident. When wild-type cells were grown on succinate in the presence of uracil or orotic acid, the activities of all 5 pyrimidine biosynthetic enzymes were depressed while the activities of 3 of the enzymes decreased in glucose-grown cells supplemented with uracil or orotic acid compared with unsupplemented cells. Pyrimidine limitation of succinate- or glucose-grown pyrimidine auxotrophic cells lacking orotate phosphoribosyltransferase activity resulted in m

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39

Holman, Michelle A., Natalie M. Williamson, and A. David Ward. "Preparation and Cyclization of Some N-(2,2-Dimethylpropargyl) Homo- and Heteroaromatic Amines and the Synthesis of Some Pyrido[2,3-d]pyrimidines." Australian Journal of Chemistry 58, no. 5 (2005): 368. http://dx.doi.org/10.1071/ch04260.

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The Cu(i) catalyzed cyclization of o-substituted N-(2,2-dimethylpropargyl)anilines yields 8-substituted 2,2-dimethyl-1,2-dihydroquinolines, while m-substituted analogues provide a mixture of 5- and 7-substituted dihydroquinoline systems. This reaction can be extended to 2-amino-N-(2,2-dimethylpropargyl)anthracene, yielding a dihydronaphtho[2,3-f]quinoline product, and to aminoquinoline derivatives, which yield substituted phenanthroline products. Pyridine analogues did not cyclize, apparently because of complexation with the copper reagent. An alternative synthetic approach to these cyclized p

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Zhang, Jieping, Shaomin Zou, Yijing Zhang, et al. "3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer." Metabolites 12, no. 5 (2022): 410. http://dx.doi.org/10.3390/metabo12050410.

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Chemoresistance limits treatment outcomes in colorectal cancer (CRC) patients. A dimeric metabolite of indole-3-carbinol, 3,3′-diindolylmethane (DIM) is abundant in cruciferous vegetables and has shown anticancer efficacy. The role of DIM in regulating chemosensitivity in CRC remains unknown. In this study, we demonstrated that DIM treatment inhibits the malignant progression of CRC. RNA sequencing indicated that pyrimidine synthesis genes are attenuated by DIM treatment. Stable 13C-labeled glucose tracing revealed that DIM inhibits de novo pyrimidine biosynthesis in CRC. DIM increases 5-FU cy

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41

Jeon, Hyejin, Yong-Guy Kim, Jin-Hyung Lee, and Jintae Lee. "Antibiofilm Activities of Halogenated Pyrimidines Against Enterohemorrhagic Escherichia coli O157:H7." International Journal of Molecular Sciences 26, no. 3 (2025): 1386. https://doi.org/10.3390/ijms26031386.

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Enterohemorrhagic Escherichia coli (EHEC) is a significant public health concern due to its ability to form biofilms, enhancing its resistance to antimicrobials and contributing to its persistence in food processing environments. Traditional antibiotics often fail to target these biofilms effectively, leading to increased bacterial resistance. This study aims to explore the efficacy of novel antibiofilm agents, specifically halogenated pyrimidine derivatives, against EHEC. We screened pyrimidine and 31 halogenated pyrimidine derivatives for their antimicrobial and antibiofilm activities agains

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42

Ren, Demin, Xiaolian Hu, Yulin Huang, and Xiaofang Li. "Synthesis of Dispiro[Indeno[1,2-b]Quinoxaline-11,3′-Pyrrolizine-2′,2″-[1,3] Thiazolo[3,2-a]Pyrimidine Via Cycloaddition Reactions." Journal of Chemical Research 42, no. 9 (2018): 453–55. http://dx.doi.org/10.3184/174751918x15349264445767.

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The 1,3-dipolar cycloaddition reaction of ethyl 5-aryl-2-(2-methoxy-2-oxoethylidene)-7-methyl-3-oxo-2,3-dihydro-5 H-[1,3]thiazolo[3,2- a] pyrimidine-6-carboxylate and azomethine ylide, which was generated in situ by the reaction of 11 H-indeno[1,2- b]quinoxalin-11-one and L-proline, afforded novel 6″ethyl 1′-methyl 5″aryl-7″methyl-3″oxo-5’,6’,7’,7a′-tetrahydro-1' H,3″ H,5″ H-dispiro[indeno[1,2- b]quinoxaline-11, 3 ‘-pyrrolizine-2’,2″-[1,3]thiazolo[3,2- a]pyrimidine-1’,6″-dicarboxylates in good yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS together

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43

Jakubiec, Dominika, and Krzysztof Z. Walczak. "A convenient synthesis of 5-(1,2,4-oxadiazol-5-yl)pyrimidine-2,4(1H,3H)-diones." Tetrahedron Letters 52, no. 51 (2011): 6890–91. http://dx.doi.org/10.1016/j.tetlet.2011.10.033.

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44

West, Thomas P. "Pyrimidine nucleotide synthesis inPseudomonascitronellolis." Canadian Journal of Microbiology 50, no. 6 (2004): 455–59. http://dx.doi.org/10.1139/w04-028.

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Pyrimidine biosynthesis was active in Pseudomonas citronellolis ATCC 13674 and appeared to be regulated by pyrimidines. When wild-type cells were grown on succinate in the presence of uracil, the de novo enzyme activities were depressed while only four enzyme activities were depressed in the glucose-grown cells. On either carbon source, orotic acid-grown cells had diminished aspartate transcarbamoylase, dihydroorotase or OMP decarboxylase activity. Pyrimidine limitation of glucose-grown pyrimidine auxotrophic cells resulted in de novo enzyme activities, except for transcarbamoyolase activity,

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45

Sim, MinHwi, Yong-Guy Kim, Jin-Hyung Lee, and Jintae Lee. "Antibiofilm Activities of Multiple Halogenated Pyrimidines Against Staphylococcus aureus." International Journal of Molecular Sciences 25, no. 23 (2024): 12830. http://dx.doi.org/10.3390/ijms252312830.

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Staphylococcus aureus, prevalent in hospital and community settings, forms biofilms that are highly resistant to antibiotics and immune responses, complicating treatment and contributing to chronic infections. These challenges underscore the need for novel treatments that target biofilm formation and effectively reduce bacterial virulence. This study investigates the antibiofilm and antimicrobial efficacy of novel halogenated pyrimidine derivatives against S. aureus, focusing on three compounds identified as potent biofilm inhibitors: 2,4-dichloro-5-fluoropyrimidine (24DC5FP), 5-bromo-2,4-dich

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46

Verma, Mohan, and Prabhakar Kumar Verma. "Synthesis, characterization, antimicrobial and anticancer evaluation of (E)-N'-benzylidene-6-methyl-4-(2-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide derivatives." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4498–502. http://dx.doi.org/10.55522/jmpas.v11i2.2190.

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The synthesis of a novel family of pyrimidine derivatives has been completed. Infrared–infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectrum data were used to describe these pyrimidine derivatives. All the compounds were evaluated for their in vitro antimicrobial activity against Gram negative strain (Escherichia coli) and Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger) and anticancer potential against Human breast cancer cell line (MCF-7). Results of antimicrobial and anticancer study revealed that

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47

Liu, Jing Jing, Hong Jing Jia, and Shou Zhi Pu. "Synthesis and Properties Study of 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(9-phenanthrene)-3-thienyl] perfluorocyclopentene." Advanced Materials Research 1003 (July 2014): 31–34. http://dx.doi.org/10.4028/www.scientific.net/amr.1003.31.

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A novel photochromic diarylethene bearing a pyrimidine moiety, 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(9-phenanthrene)-3-thienyl] perfluorocyclopentene has been synthesized. Its properties, including photochromic behavior and fluorescent properties, have been investigated. The compound exhibited remarkable photochromism, changing from colorless to red after irradiation with UV light in solution. The fluorescence had a remarkable initial increase with subsequent dramatic decrease with increasing concentration. The results indicated that the pyrimidine moiety played a very important role

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48

Rees, DC, J. Duley, HA Simmonds, et al. "Interaction of hemoglobin E and pyrimidine 5' nucleotidase deficiency." Blood 88, no. 7 (1996): 2761–67. http://dx.doi.org/10.1182/blood.v88.7.2761.bloodjournal8872761.

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A Bangladeshi family is described in which the genes for both hemoglobin E (Hb E) and pyrimidine 5′ nucleotidase deficiency are segregating. An individual homozygous for both these conditions has a severe hemolytic anemia, whereas family members who are homozygous for Hb E are asymptomatic and those homozygous for pyrimidine 5′ nucleotidase deficiency have the mild hemolytic anemia that is characteristic of this disorder. Globin-chain synthesis experiments have shown that the mechanism underlying the interaction between these two genotypes is a marked decrease in the stability of Hb E in pyrim

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Vlasov, Sergiy V., Hanna I. Severina, Oleksandr V. Borysov, et al. "Synthesis and Antimicrobial Evaluation of 2-(6-Imidazo[1,2-a]pyridin-2-yl-5-methyl-2,4-dioxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl)-N-arylacetamide Derivatives." Molbank 2022, no. 1 (2022): M1331. http://dx.doi.org/10.3390/m1331.

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6-Heteryl-5-methylthieno[2,3-d]pyrimidin-2,4(1H,3H)-diones are of great interest as the promising objects for the search of antibacterials. In this communication, we obtained 6-(imidazo[1,2-a]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione by interaction of 6-(bromoacetyl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione with 2-aminopyridine. The obtained heterocyclic hybrid was further modified by alkylation with 2-chloroarylacetamides. Antimicrobial activity studies for the synthesized compounds using the agar well diffusion method revealed their moderate act

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Liu, Jing Jing, Hong Jing Jia, and Shou Zhi Pu. "Synthesis and Properties Study of 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(4-n-pentylbenzene)-3-thienyl] Perfluorocyclopentene." Advanced Materials Research 952 (May 2014): 75–78. http://dx.doi.org/10.4028/www.scientific.net/amr.952.75.

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A novel photochromic diarylethene based on a six-membered pyrimidine moiety 1-(2,4-dimethoxyl-5-pyrimidinyl)-2-[2-methyl-5-(4-n-pentylbenzene)-3-thienyl] perfluorocyclopent-ene has been synthesized. Its properties, including photochromic behavior and fluorescent properties, have been investigated. The compounds exhibited remarkable photochromism, changing from colorless to red after irradiation with UV light both in solution and in PMMA film. The fluorescence had a remarkable initial increase with subsequent dramatic decrease with increasing concentration. The results indicated that the pyrimi

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