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Relevant bibliographies by topics / 5-HIAA/Cr

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Journal articles

Academic literature on the topic '5-HIAA/Cr'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "5-HIAA/Cr"

1

Gerald, M. Higa, Cumpston Aaron, L. Auber Miklos, and Hobbs Gerry. "Further Evidence of an Association Between the Ratio of Substance P to 5-HIAA/Cr and Delayed Chemotherapy-induced Vomiting." Biohelikon 2, no. 1 (2014): 1–5. https://doi.org/10.5281/zenodo.814319.

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Substantial evidence support the role of serotonin and substance P as mediators of chemotherapy-induced vomiting. Preliminary data suggested that the numerical ratio of the two neurotransmitters could be a novel marker associated with delayed emesis. However, because of the small number of subjects and variable treatment regimens in the early report, additional patients were enrolled into the clinical study to determine whether the association persisted in a more homogeneous group of subjects.

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2

Chojnacki, Jan, Paulina Konrad, Marta Mędrek-Socha, et al. "The Variability of Tryptophan Metabolism in Patients with Mixed Type of Irritable Bowel Syndrome." International Journal of Molecular Sciences 25, no. 5 (2024): 2550. http://dx.doi.org/10.3390/ijms25052550.

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Patients with a mixed type of irritable bowel syndrome (IBS-M) experience constipation and diarrhea, which alternate between weeks or months. The pathogenesis of this syndrome is still little understood. The aim of the study was mainly to evaluate the urinary excretion of selected tryptophan (TRP) metabolites during the constipation and diarrhea periods of this syndrome. In 36 patients with IBS-M and 36 healthy people, serum serotonin level was measured by ELISA and urinary levels of 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN) and indican (3-IS) were determined using the LC-MS/MS met

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3

Kvols, L., B. Wiedenmann, K. Oberg, et al. "Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4082. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4082.

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4082 Background: Pasireotide is a novel multiligand somatostatin analogue that exhibits high binding affinity to 4 of 5 somatostatin receptor subtypes: sst1,2,3 and sst5. Compared with octreotide, pasireotide has 30, 5 and 40 times greater affinity for sst1,3 and sst5 receptors respectively and a comparable affinity for sst2. Methods: This was a Phase II, open-label, multicenter study in patients with metastatic carcinoid tumors whose symptoms (diarrhea and flushing) were inadequately controlled by octreotide LAR. Patients had histopathologically confirmed disease, elevated 5-HIAA and/or CgA l

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4

Higa, GM, ML Auber, and G. Hobbs. "Validation Trial of a Novel Marker of Delayed Chemotherapy-induced Emesis." October 19, 2016. https://doi.org/10.19070/2167-9118-1600020.

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Post hoc analyses of study data suggested that the ratio of substance P to 5-HIAA/creatinine was a novel marker associated with risk of developing delayed chemotherapy-induced emesis. In order to verify this finding, a new clinical trial was conducted to prospectively evaluate the marker in patients receiving chemotherapy of high emetic risk level. Treatment in this study was restricted to two doxorubicin and cyclophosphamide-containing regimens. Prior to chemotherapy, blood and urine samples were collected. Serum substance P and urine 5-HIAA and creatinine (Cr) were measured to calculate pati

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5

Burks, Margaret L., and Shichun Bao. "THE 24-HOUR URINARY 5-HIAA: A SIMPLE TEST WITH A COMMON PITFALL." AACE Clinical Case Reports, December 2015. http://dx.doi.org/10.4158/ep15794.cr.

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