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1

RAGHAVENDRA, G. JOSHI, S. GADAGINAMATH GURU, and G. PUJAR BASAYYA. "Synthesis and Antimicrobial Activity of some New 4-Isogramines, 4-Arylthiomethyl and 4-Arylazo Derivatives of 5-Hydroxyindoles." Journal of Indian Chemical Society Vol. 71, April 1994 (1994): 175–78. https://doi.org/10.5281/zenodo.5894221.

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Department of Chemistry, Karnatak. University, Dharwad-580 003 <em>Manuscript received 22 March 1993. accepted 3 June 1993</em> Mannich reaction of 5-hydroxyindoles (1-10) .with formaldehyde and secondary amines produced the 4-isogramines (11-48). The nucleophilic displacement of dimethylamine from 4-dimethylaminomethyl-5-hydroxyindoles (11-15) was effected by heating them with thiophenols to get 4-arylthiomethyl-5-hydroxyindoles (49-58). The treatment of 5-hydroxyindoles (1-4 and 6-9) with aryldiazonium salt solution afforded exclusively 4-arylazo-5-hydroxyindoles (59-74). All the compounds w
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2

Yamazaki, Yoshimitsu, and Yasuhiro Kawano. "Inhibitory Effect of Hydroxyindoles and their Analogues on Human Melanoma Tyrosinase." Zeitschrift für Naturforschung C 65, no. 1-2 (2010): 49–54. http://dx.doi.org/10.1515/znc-2010-1-209.

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A recent study showed that N-acylserotonin derivatives have strong inhibitory activity against tyrosinase. To clarify the role of the 5-hydroxy group in the indole ring, 2-, 4-, 5-, 6-, and 7-hydroxyindole and 11 related compounds such as 5-hydroxyindan and 6-hydroxyquinoline were tested for their inhibition of catecholase activity of tyrosinase from human HMVII melanoma cells. 6-Hydroxyindole (5) and 7-hydroxyindole (6) were potent inhibitors, while 5-hydroxyindole (4) was a weaker inhibitor than the above-mentioned compounds (IC50 = 20, 79, 366, and 342 μM for 5, 6, 4, and kojic acid, respec
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3

Lee, Jintae, Tarun Bansal, Arul Jayaraman, William E. Bentley, and Thomas K. Wood. "Enterohemorrhagic Escherichia coli Biofilms Are Inhibited by 7-Hydroxyindole and Stimulated by Isatin." Applied and Environmental Microbiology 73, no. 13 (2007): 4100–4109. http://dx.doi.org/10.1128/aem.00360-07.

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ABSTRACT Since indole is present at up to 500 μM in the stationary phase and is an interspecies biofilm signal (J. Lee, A. Jayaraman, and T. K. Wood, BMC Microbiol. 7:42, 2007), we investigated hydroxyindoles as biofilm signals and found them also to be nontoxic interspecies biofilm signals for enterohemorrhagic Escherichia coli O157:H7 (EHEC), E. coli K-12, and Pseudomonas aeruginosa. The genetic basis of EHEC biofilm formation was also explored, and notably, virulence genes in biofilm cells were repressed compared to those in planktonic cells. In Luria-Bertani medium (LB) on polystyrene with
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4

Yokoyama, Masataka, Satoshi Watanabe, and Hidekatsu Hatanaka. "Synthesis ofN-Substituted 5-Hydroxyindoles." Synthesis 1987, no. 09 (1987): 846–48. http://dx.doi.org/10.1055/s-1987-28100.

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5

Chirkova, Zhanna V. "SYNTHESIS OF N-HYDROXYINDOLES." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 4 (2017): 4. http://dx.doi.org/10.6060/tcct.2017604.5560.

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The basic synthetic methods for obtaining N-hydroxyindoles were studied. The first method is intramolecular reductive cyclization of ortho-substituted nitroaromatic compounds by various reducing agents. Nitrophenyl acetaldehydes (synthesis by Acheson), N,N-disubstituted amino-2-nitrostyrenes (synthesis by Somei), ortho-nitroketoetheres of different structure or 1-(o-nitroarene)-1-cyanoalkylnitroketones, ortho-nitrophenylacetonitriles were used as substrates for the synthesis of N-hydroxyindoles. Titanium chloride (III), zinc in THF solution of ammonium chloride or in acetic acid, stannous chlo
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6

Hanuszewska, Maria, Magdalena Prusik, and Bogdan Lewczuk. "Embryonic Ontogeny of 5-Hydroxyindoles and 5-Methoxyindoles Synthesis Pathways in the Goose Pineal Organ." International Journal of Molecular Sciences 20, no. 16 (2019): 3948. http://dx.doi.org/10.3390/ijms20163948.

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The aim of this study was to characterize the embryonic ontogeny of 5-hydroxyindoles and 5-methoxyindoles synthesis pathways in the goose pineal organ. The study was performed on embryos aged 14–28 days, which have been incubated under a 12L:12D cycle. The pineal organs were collected for measurements of indole content by HPLC every 6 h on embryonic day (ED) 14, ED 16, ED 18 and ED 22 or every 2 h on ED 24, ED 26 and ED 28. The level of tryptophan showed no significant changes during development and no day-night variations. The content of 5-hydroxytryptophan increased between ED 14 and ED 26.
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7

Ozaki, Yutaka, Kyouko Okamura, Ayako Hosoya, and Sang-Won Kim. "A New Approach to 5-Hydroxyindoles from 1,4-Cyclohexanedione." Chemistry Letters 26, no. 7 (1997): 679–80. http://dx.doi.org/10.1246/cl.1997.679.

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8

LaPorte, Matthew, Ki Bum Hong, Jie Xu, and Peter Wipf. "5-Hydroxyindoles by Intramolecular Alkynol–Furan Diels–Alder Cycloaddition." Journal of Organic Chemistry 78, no. 1 (2012): 167–74. http://dx.doi.org/10.1021/jo3022605.

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9

Panisheva, E. K., �. S. Krichevskii, I. S. Nikolaeva, et al. "Aminoalkyl-5- and -6-hydroxyindoles and their antiviral activity." Pharmaceutical Chemistry Journal 23, no. 2 (1989): 153–55. http://dx.doi.org/10.1007/bf00764467.

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10

Sharapov, Ainur D., Ramil F. Fatykhov, Igor A. Khalymbadzha, et al. "Fluorescent Pyranoindole Congeners: Synthesis and Photophysical Properties of Pyrano[3,2-f], [2,3-g], [2,3-f], and [2,3-e]Indoles." Molecules 27, no. 24 (2022): 8867. http://dx.doi.org/10.3390/molecules27248867.

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This paper reports the synthesis of four types of annulated pyranoindole congeners: pyrano[3,2-f]indole, pyrano[2,3-g]indole, pyrano[2,3-f]indole, and pyrano[2,3-e]indole and photophysical studies in this series. The synthesis of pyrano[3,2-f], [2,3-g], and [2,3-e]indoles involve a tandem of Bischler–Möhlau reaction of 3-aminophenol with benzoin to form 6-hydroxy- or 4-hydroxyindole followed by Pechmann condensation of these hydroxyindoles with β-ketoesters. Pyrano[2,3-f]indoles were synthesized through the Nenitzescu reaction of p-benzoquinone and ethyl aminocrotonates and subsequent Pechmann
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11

Hermans, Rebecca, Max Van Hoof, Luc Van Meervelt, and Wim Dehaen. "Exploration of the Divergent Outcomes for the Nenitzescu Reaction of Piperazinone Enaminoesters." Organics 4, no. 2 (2023): 146–63. http://dx.doi.org/10.3390/org4020012.

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The Nenitzescu reaction is a condensation reaction between an enamine and a quinone, which can give rise to a wide variety of reaction products depending on the nature of the starting material and the reaction conditions. The most commonly observed products are 5-hydroxyindoles and 5-hydroxybenzofurans. Both classes are of interest since they are known to possess a variety of promising bioactivities. Despite the high chemodivergency for this reaction, it remains an interesting synthetic strategy thanks to the mild reaction conditions, easily accessible starting materials and simple reaction pr
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12

Oura, Hiromu, Yosuke Tashiro, Masanori Toyofuku, et al. "Inhibition of Pseudomonas aeruginosa Swarming Motility by 1-Naphthol and Other Bicyclic Compounds Bearing Hydroxyl Groups." Applied and Environmental Microbiology 81, no. 8 (2015): 2808–18. http://dx.doi.org/10.1128/aem.04220-14.

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ABSTRACTMany bacteria convert bicyclic compounds, such as indole and naphthalene, to oxidized compounds, including hydroxyindoles and naphthols.Pseudomonas aeruginosa, a ubiquitous bacterium that inhabits diverse environments, shows pathogenicity against animals, plants, and other microorganisms, and increasing evidence has shown that several bicyclic compounds alter the virulence-related phenotypes ofP. aeruginosa. Here, we revealed that hydroxyindoles (4- and 5-hydroxyindoles) and naphthalene derivatives bearing hydroxyl groups specifically inhibit swarming motility but have minor effects on
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13

Patil, Shivaputra, Renukadevi Patil, and Duane Miller. "Synthetic Applications of the Nenitzescu Reaction to Biologically Active 5-Hydroxyindoles." Current Organic Chemistry 12, no. 9 (2008): 691–717. http://dx.doi.org/10.2174/138527208784567223.

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14

Player, Mark R., and J. Walter Sowell. "Synthesis of 1,3-disubstituted-2-amino-5-hydroxyindoles by reductive aromatization." Journal of Heterocyclic Chemistry 30, no. 1 (1993): 125–28. http://dx.doi.org/10.1002/jhet.5570300122.

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15

OZAKI, Y., K. OKAMURA, A. HOSOYA, and S. W. KIM. "ChemInform Abstract: A New Approach to 5-Hydroxyindoles from 1,4-Cyclohexanedione." ChemInform 28, no. 47 (2010): no. http://dx.doi.org/10.1002/chin.199747138.

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16

LaPorte, Matthew, Ki Bum Hong, Jie Xu, and Peter Wipf. "ChemInform Abstract: 5-Hydroxyindoles by Intramolecular Alkynol-Furan Diels-Alder Cycloaddition." ChemInform 44, no. 20 (2013): no. http://dx.doi.org/10.1002/chin.201320129.

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17

Wiseman-Distler, M. H., and T. L. Sourkes. "THE EFFECT OF 4-HYDROXYINDOLES ON THE METABOLISM OF 5-HYDROXYTRYPTAMINE (SEROTONIN) *." Annals of the New York Academy of Sciences 96, no. 1 (2006): 142–51. http://dx.doi.org/10.1111/j.1749-6632.1962.tb50109.x.

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18

Yokogoshi, Hidehiko, and Yukiko Kato. "Dose-dependent Changes in Brain 5-Hydroxyindoles Caused by Caffeine in Rats." Bioscience, Biotechnology, and Biochemistry 56, no. 12 (1992): 2083–84. http://dx.doi.org/10.1271/bbb.56.2083.

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19

Troschütz, Reinhard, and Jens Landwehr. "Synthesis of 3-EWG-Substituted 2-Amino-5-hydroxyindoles via Nenitzescu Reaction." Synthesis, no. 14 (2005): 2414–20. http://dx.doi.org/10.1055/s-2005-872074.

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20

Rogers, K. J., and V. Dubowitz. "5-Hydroxyindoles in Hydrocephalus. A Comparative Study of Cerebrospinal Fluid and Blood Levels." Developmental Medicine & Child Neurology 12, no. 4 (2008): 461–66. http://dx.doi.org/10.1111/j.1469-8749.1970.tb01940.x.

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21

Ishida, Junichi, Ryuji Iizuka, and Masatoshi Yamaguchi. "High-performance liquid chromatographic determination of 5-hydroxyindoles by post-column fluorescence derivatization." Analyst 118, no. 2 (1993): 165. http://dx.doi.org/10.1039/an9931800165.

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22

PLAYER, M. R., and J. W. SEN SOWELL. "ChemInform Abstract: Synthesis of 1,3-Disubstituted-2-amino-5-hydroxyindoles by Reductive Aromatization." ChemInform 24, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199336170.

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23

Finocchiaro, L. M. E., V. E. Nahmod, and J. M. Launay. "Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes." Biochemical Journal 280, no. 3 (1991): 727–31. http://dx.doi.org/10.1042/bj2800727.

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Cultured human peripheral blood mononuclear leucocytes (PBML) were able to synthesize indoleamines, including melatonin, and were also able to convert melatonin taken up from the incubation medium into N-acetyl-5-hydroxytryptamine (NAHT) and 5-hydroxytryptamine (5-HT). These compounds were analysed by h.p.l.c., and melatonin was additionally characterized by two-dimensional t.l.c., mass spectrometry and radioimmunoassay. Only hydroxyindoles were detected by h.p.l.c. in unstimulated PBML culture. Sustained stimulation by melatonin or interferon-gamma (IFN-gamma) increased markedly the basal pro
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24

TODOROKI, Kenichiro, Masae ARISAKA, Yoshihiko NAKASHIMA, Hideyuki YOSHIDA, Hitoshi NOHTA, and Masatoshi YAMAGUCHI. "Liquid Chromatography of 5-hydroxyindoles Based on Pre-Column Fluorescence Derivatization by Photocatalytic Oxidation." BUNSEKI KAGAKU 54, no. 12 (2005): 1211–14. http://dx.doi.org/10.2116/bunsekikagaku.54.1211.

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25

Stoffman, Elia J. L., and Derrick L. J. Clive. "The coumarin→indole transformation—a method for preparing 4-halo-5-hydroxyindoles from coumarins." Organic & Biomolecular Chemistry 7, no. 23 (2009): 4862. http://dx.doi.org/10.1039/b914580j.

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26

Dubowitz, Victor, and K. J. Rogers. "5-Hydroxyindoles in the Cerebrospinal Fluid of Infants with Down's Syndrome and Muscle Hypotonia." Developmental Medicine & Child Neurology 11, no. 6 (2008): 730–34. http://dx.doi.org/10.1111/j.1469-8749.1969.tb01516.x.

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27

Ivan, Beatrice Cristina, Mino Rodolfo Caira, and Florea Dumitrascu. "Nenitzescu Indole Synthesis: 1929-2019 Unexpected Formation of a Pyrrole-Azepine Hybrid in the Nenitzescu Indole Synthesis: A Reinvestigation." Revista de Chimie 71, no. 5 (2020): 51–57. http://dx.doi.org/10.37358/rc.20.5.8112.

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The condensation of 1,4-benzoquinones with enamines reported ninety years ago is a name reaction known as the Nenitzescu indole synthesis which has proved to be a very useful method for obtaining both 5-hydroxyindoles and nonindole derivatives. An unexpected compound containing two condensed azepine rings was isolated in 1988 from the reaction between 1,4-benzoquinone and ethyl 3-aminocinnamate performed in 1-butanol. The reinvestigation of the proposed bisazepine structure by X-ray analysis revealed instead a pyrrole-azepine hybrid having the two heterocycles rings connected by a double bond.
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28

TODOROKI, Kenichiro, Masaki NAKANO, Hideyuki YOSHIDA, Hitoshi NOHTA, and Masatoshi YAMAGUCHI. "Sensitive and Selective LC Determination of 5-Hydroxyindoles Through Online Electrochemical Fluorescence Derivatization Using Benzylamine." CHROMATOGRAPHY 42, no. 1 (2021): 55–60. http://dx.doi.org/10.15583/jpchrom.2020.022.

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29

Satta, Giuseppe, Elena Usala, Angelo Solinas, et al. "Nenitzescu Synthesis of 5‐Hydroxyindoles with Zinc, Iron and Magnesium Salts in Cyclopentyl Methyl Ether." European Journal of Organic Chemistry 2021, no. 42 (2021): 5835–42. http://dx.doi.org/10.1002/ejoc.202101045.

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30

Yokogoshi, Hidehiko, Yukiko Kato, Yuko M. Sagesaka, Takanobu Takihara-Matsuura, Takami Kakuda, and Naokazu Takeuchi. "Reduction Effect of Theanine on Blood Pressure and Brain 5-Hydroxyindoles in Spontaneously Hypertensive Rats." Bioscience, Biotechnology, and Biochemistry 59, no. 4 (1995): 615–18. http://dx.doi.org/10.1271/bbb.59.615.

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31

Ishida, Junichi, Masatoshi Yamaguchi, and Masaru Nakamura. "Spectrofluorimetric determination of 5-hydroxyindoles with benzylamine or 3,4-dimethoxybenzylamine as a selective fluorogenic reagent." Analyst 116, no. 3 (1991): 301. http://dx.doi.org/10.1039/an9911600301.

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32

Sakaguchi, Yohei, Jun Ikenaga, Hideyuki Yoshida, et al. "Selective and sensitive liquid chromatographic determination method of 5-hydroxyindoles with fluorous and fluorogenic derivatization." Journal of Pharmaceutical and Biomedical Analysis 114 (October 2015): 348–54. http://dx.doi.org/10.1016/j.jpba.2015.06.003.

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33

Ishida, Junichi, Tomohiro Yakabe, Hitoshi Nohta, and Masatoshi Yamaguchi. "6-Aminomethylphthalhydrazide as a highly sensitive chemiluminescence derivatization reagent for 5-hydroxyindoles in liquid chromatography." Analytica Chimica Acta 346, no. 2 (1997): 175–81. http://dx.doi.org/10.1016/s0003-2670(97)00122-0.

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34

Todoroki, Kenichiro, Yoshihiko Nakashima, Hideyuki Yoshida, Hitoshi Nohta, and Masatoshi Yamaguchi. "Online photocatalytic device for highly selective pre-column fluorescence derivatization of 5-hydroxyindoles with benzylamine." Analytica Chimica Acta 555, no. 1 (2006): 14–19. http://dx.doi.org/10.1016/j.aca.2005.08.076.

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35

Baker, Peter C., and Kenneth M. Hoff. "The effects of acute and extended monoamine oxidase inhibition upon 5-hydroxyindoles in maturing mouse brain." General Pharmacology: The Vascular System 22, no. 2 (1991): 347–52. http://dx.doi.org/10.1016/0306-3623(91)90462-f.

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36

Mukhanova, T. I., L. M. Alekseeva, E. F. Kuleshova, Yu N. Sheinker, and V. G. Granik. "Synthesis of 3-acyl-5-hydroxyindoles and 3-acyl-5-hydroxybenzofurans. Influence of solvent on the course of the Nenitzescu reaction." Pharmaceutical Chemistry Journal 27, no. 2 (1993): 136–42. http://dx.doi.org/10.1007/bf00781075.

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37

Loots, W., and F. De Clerck. "5-Hydroxytryptamine dominates over thromboxane A2 in reducing collateral blood flow by activated platelets." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 1 (1993): H158—H164. http://dx.doi.org/10.1152/ajpheart.1993.265.1.h158.

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Intra-aortic infusion of collagen (100 micrograms/kg in 1 min) elicited an extensive platelet activation and transient but marked reductions of blood flow and increases of peripheral vascular resistance, both responses being more pronounced in collaterals than in normal arterial beds in feline hind legs. Blockade of 5-hydroxytryptamine (5-HT) subtype 2 (5-HT2) receptors for 5-HT (ketanserin or ritanserin, 0.63 mg/kg iv, -10 min) or amine depletion (reserpine, 0.1 mg/kg im, -10 days, + parachlorophenylalanine 100 mg/kg sc daily for 3 days), but not cyclooxygenase inhibition (indomethacin, 5 mg/
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38

Nagai, Yasuo, Shigehiko Narumi, Akinobu Nagaoka, and Yuji Nagawa. "In vivo electrochemical detection of 5-hydroxyindoles in the dorsal hippocampus of anesthetized rats treated with idebenone (CV-2619)." Japanese Journal of Pharmacology 39 (1985): 374. http://dx.doi.org/10.1016/s0021-5198(19)63911-9.

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39

NAGAI, Yasuo, Shigehiko NARUMI, Akinobu NAGAOKA, and Yuji NAGAWA. "In Vivo Electrochemical Detection of 5-Hydroxyindoles in the Dorsal Hippocampus of Anesthetized Rats Treated with Idebenone (CV-2619)." Japanese Journal of Pharmacology 37, no. 2 (1985): 222–25. http://dx.doi.org/10.1254/jjp.37.222.

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40

Cespuglio, R., S. Burlet, and H. Faradji-Prevautel. "5-Hydroxyindoles compounds and nitric oxide voltammetric detection in the rat brain: changes occurring throughout the sleep-wake cycle." Journal of Neural Transmission 105, no. 2-3 (1998): 205–15. http://dx.doi.org/10.1007/s007020050049.

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41

Xiao, Mengjie, Dengfeng Xu, Weihong Liang, Wenyu Wu, Albert S. C. Chan, and Junling Zhao. "Front Cover Picture: Organocatalytic Enantioselective Friedel-Crafts Alkylation/Lactonization Reaction of Hydroxyindoles with Methyleneoxindoles (Adv. Synth. Catal. 5/2018)." Advanced Synthesis & Catalysis 360, no. 5 (2018): 815. http://dx.doi.org/10.1002/adsc.201800010.

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42

Al-Kazwini, Akeel T., Peter O'Neill, Gerald E. Adams, Robert B. Cundall, Alex Junino, and Jean Maignan. "Characterisation of the intermediates produced upon one-electron oxidation of 4-, 5-, 6- and 7-hydroxyindoles by the azide radical." Journal of the Chemical Society, Perkin Transactions 2, no. 4 (1992): 657. http://dx.doi.org/10.1039/p29920000657.

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43

Wolf, William A., and Donald M. Kuhn. "Uptake and Release of Tryptophan and Serotonin: An HPLC Method to Study the Flux of Endogenous 5-Hydroxyindoles Through Synaptosomes." Journal of Neurochemistry 46, no. 1 (1986): 61–67. http://dx.doi.org/10.1111/j.1471-4159.1986.tb12925.x.

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44

Hayama, Tadashi, Yurika Yabuuchi, Tomomi Iwamatsu, et al. "Concerted derivatization and concentration method with dispersive liquid–liquid microextraction for liquid chromatographic analysis of 5-hydroxyindoles in human serum." Talanta 117 (December 2013): 27–31. http://dx.doi.org/10.1016/j.talanta.2013.08.035.

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45

JOSHI, R. G., G. S. GADAGINAMATH, and B. G. PUJAR. "ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New 4-Isogramines, 4- Arylthiomethyl and 4-Arylazo Derivatives of 5-Hydroxyindoles." ChemInform 26, no. 21 (2010): no. http://dx.doi.org/10.1002/chin.199521132.

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46

Ishida, Junichi, Maki Takada, Nohta Hitoshi, Ryuji Iizuka, and Masatoshi Yamaguchi. "4-Dimethylaminobenzylamine as a sensitive chemiluminescence derivatization reagent for 5-hydroxyindoles and its application to their quantification in human platelet-poor plasma." Journal of Chromatography B: Biomedical Sciences and Applications 738, no. 2 (2000): 199–206. http://dx.doi.org/10.1016/s0378-4347(99)00503-4.

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47

Wu, Yu-Bo, Jian-Hong Wu, Zhi-Guo Shi, and Yu-Qi Feng. "Simultaneous determination of 5-hydroxyindoles and catechols from urine using polymer monolith microextraction coupled to high-performance liquid chromatography with fluorescence detection." Journal of Chromatography B 877, no. 20-21 (2009): 1847–55. http://dx.doi.org/10.1016/j.jchromb.2009.05.006.

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48

Fujino, Kaoru, Takashi Yoshitake, Jan Kehr, Hitoshi Nohta, and Masatoshi Yamaguchi. "Simultaneous determination of 5-hydroxyindoles and catechols by high-performance liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine." Journal of Chromatography A 1012, no. 2 (2003): 169–77. http://dx.doi.org/10.1016/s0021-9673(03)01180-4.

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49

Yokogoshi, Hidehiko, Tomoko Iwata, Kyoji Ishida, and Akira Yoshida. "Effect of Amino Acid Supplementation to Low Protein Diet on Brain and Plasma Levels of Tryptophan and Brain 5-Hydroxyindoles in Rats." Journal of Nutrition 117, no. 1 (1987): 42–47. http://dx.doi.org/10.1093/jn/117.1.42.

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50

AL-KAZWINI, A. T., P. O'NEILL, G. E. ADAMS, R. B. CUNDALL, A. JUNINO, and J. MAIGNAN. "ChemInform Abstract: Characterization of the Intermediates Produced Upon One-Electron Oxidation of 4-, 5-, 6- and 7-Hydroxyindoles by the Azide Radical." ChemInform 23, no. 33 (2010): no. http://dx.doi.org/10.1002/chin.199233103.

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