Relevant bibliographies by topics / 5-Nitro indazole

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Academic literature on the topic '5-Nitro indazole'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "5-Nitro indazole"

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Pozo-Martínez, Josué, Vicente J. Arán, Matías Zúñiga-Bustos, et al. "In Vitro Evaluation of New 5-Nitroindazolin-3-one Derivatives as Promising Agents against Trypanosoma cruzi." International Journal of Molecular Sciences 25, no. 20 (2024): 11107. http://dx.doi.org/10.3390/ijms252011107.

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Chagas disease is a prevalent health problem in Latin America which has received insufficient attention worldwide. Current treatments for this disease, benznidazole and nifurtimox, have limited efficacy and may cause side effects. A recent study proposed investigating a wide range of nitroindazole and indazolone derivatives as feasible treatments. Therefore, it is proposed that adding a nitro group at the 5-position of the indazole and indazolone structure could enhance trypanocidal activity by inducing oxidative stress through activation of the nitro group by NTRs (nitroreductases). The study
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Saghdani, Nassima, Abdelali Chihab, Nabil El Brahmi, and Saïd El Kazzouli. "Synthesis and Characterization of Novel Indazole–Sulfonamide Compounds with Potential MAPK1 Inhibitory Activity for Cancer Treatment." Molbank 2024, no. 3 (2024): M1858. http://dx.doi.org/10.3390/m1858.

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Indazoles are a very important group of nitrogen-containing heterocycles with a wide range of biological and medicinal applications. These properties make them highly attractive for drug development, particularly when combined with sulfonamides to enhance their medicinal potential. In this work, we synthesized an indazole-based sulfonamide, namely the 1-((2-chloro-5-methoxyphenyl)sulfonyl)-5-nitro-1H-indazole (3). The reduction of the nitro group of 5-nitroindazole (1) to its corresponding amine was also performed to yield compound (4). Both compounds’ structures were elucidated using various
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3

Chen, Dong-Mei, Jia-Yan Liu, Ming Wei, Bing-Wei Wang, Ruo-Han Chu, and Dong-Sheng Chen. "Synthesis of indazolo[5,4-b][1,6]naphthyridine and indazolo[6,7-b][1,6]naphthyridine derivatives." Heterocyclic Communications 25, no. 1 (2019): 15–21. http://dx.doi.org/10.1515/hc-2019-0006.

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AbstractA simple method for the synthesis of the title compounds by an efficient in-situ reduction and cyclization reactions of aromatic aldehydes, tert-butyl 2,4-dioxopiperidine-1-carboxylate and 5-nitro-1H-indazole or 6-nitro-1H-indazole was developed.
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Chicha, Hakima, El Mostapha Rakib, Domenico Spinelli, Mohamed Saadi, and Lahcen El Ammari. "1-Allyl-3-chloro-5-nitro-1H-indazole." Acta Crystallographica Section E Structure Reports Online 69, no. 9 (2013): o1410. http://dx.doi.org/10.1107/s1600536813021995.

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5

Bui, Thi Thanh Cham, Hue Linh Luu, Thi Thanh Luong, et al. "An Alternative Method for Synthesizing N,2,3-Trimethyl-2H-indazol-6-amine as a Key Component in the Preparation of Pazopanib." Chemistry 6, no. 5 (2024): 1089–98. http://dx.doi.org/10.3390/chemistry6050063.

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Due to its application as an anti-cancer drug, pazopanib (1) has attracted the interest of many researchers, and several studies on pazopanib synthesis have been reported over the years. This paper provides a novel route for synthesizing N,2,3-trimethyl-2H-indazol-6-amine (5), which is a crucial building block in the synthesis of pazopanib from 3-methyl-6-nitro-1H-indazole (6). By alternating between the reduction and two methylation steps, compound 5 was obtained in a yield comparable (55%) to what has been reported (54%). It is noteworthy that the last step of N2-methylation also yielded N,N
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6

Boulhaoua, Mohammed, Sevgi Kansiz, Mohamed El Hafi, et al. "Crystal structure and Hirshfeld surface analysis of 5-[(5-nitro-1H-indazol-1-yl)methyl]-3-phenyl-4,5-dihydroisoxazole." Acta Crystallographica Section E Crystallographic Communications 75, no. 1 (2019): 71–74. http://dx.doi.org/10.1107/s2056989018017590.

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In the title compound, C17H14N4O3, the indazole unit is planar to within 0.0171 (10) Å and makes dihedral angles of 6.50 (6) and 6.79 (4)°, respectively, with the nitro and pendant phenyl groups. The conformation of the oxazole ring is best described as an envelope. In the crystal, oblique stacks along the a-axis direction are formed by π–π stacking interactions between the indazole unit and the pendant phenyl rings of adjacent molecules. The stacks are linked into pairs through C—H...O hydrogen bonds. Hirshfeld surface analysis and two-dimensional fingerprint plots indicate that the most impo
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Kouakou, Assoman, El Mostapha Rakib, Mohamed Chigr, Mohamed Saadi, and Lahcen El Ammari. "Crystal structure of 3-chloro-1-methyl-5-nitro-1H-indazole." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): o834—o835. http://dx.doi.org/10.1107/s2056989015018411.

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The molecule of the title compound, C8H6ClN3O2, is built up from fused five- and six-membered rings connected to a chlorine atom and to nitro and methyl groups. The indazole system is essentially planar with the largest deviation from the mean plane being 0.007 (2) Å. No classical hydrogen bonds are observed in the structure. Two molecules form a dimer organised by a symmetry centreviaa close contact between a nitro-O atom and the chlorine atom [at 3.066 (2) Å this is shorter than the sum of their van der Waals radii].
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8

Pakjoo, Vahid, Mina Roshani, Mehdi Pordel, and Toktam Hoseini. "Synthesis of new fluorescent compounds from 5-nitro-1H-indazole." Arkivoc 2012, no. 9 (2012): 195–203. http://dx.doi.org/10.3998/ark.5550190.0013.917.

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Pinard, Elisabeth, Nicolas Engrand, and Jacques Seylaz. "Dynamic Cerebral Microcirculatory Changes in Transient Forebrain Ischemia in Rats: Involvement of Type I Nitric Oxide Synthase." Journal of Cerebral Blood Flow & Metabolism 20, no. 12 (2000): 1648–58. http://dx.doi.org/10.1097/00004647-200012000-00004.

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The diameter of surface microvessels and the erythrocyte velocity and flux through intraparenchymal capillaries in the parietal cortex were measured during transient global cerebral ischemia and reperfusion using laser-scanning confocal fluorescence microscopy in anesthetized rats. The role of nitric oxide (NO) from neurons in the microcirculatory changes was also investigated using 7-nitro-indazole (7-NI, 25 mg/kg, IP). Wistar rats (4 per group) equipped with a closed cranial window were given fluorescein isothiocyanate (FITC)-Dextran and FITC-labeled erythrocytes intravenously to respectivel
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Cuartas, Crespo, Priego, et al. "Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity." Molecules 24, no. 23 (2019): 4236. http://dx.doi.org/10.3390/molecules24234236.

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New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid. The resulting conformationally-constrained compounds were evaluated for their antiproliferative activity against selected cancer cell lines. The nitro-based indazoles 11a, 11b, 12a and 12b have shown IC50 values between 5–15 μM against the lung carcinoma cell line NCI-H460. Moreover, the nitro compounds were tested for antibacterial activity where compounds 12a and 13b have shown MIC values of 250 and 62.5 μg/mL agains
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Book chapters on the topic "5-Nitro indazole"

1

Yang, Z. W., Y. Shen, and F. S. Mi. "THE STUDY ON THE MECHANISM OF 6-NITRO-INDAZOLE AS A RADIOSENSITIZER." In Radiation Research: A Twentieth-century Perspective. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-12-168561-4.50308-5.

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