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Relevant bibliographies by topics / 5-nitroimidazoles

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Academic literature on the topic '5-nitroimidazoles'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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Journal articles on the topic "5-nitroimidazoles"

1

Kanda, Maki, Takeo Sasamoto, Kazue Takeba, et al. "Rapid Determination of Nitroimidazole Residues in Honey by Liquid Chromatography/Tandem Mass Spectrometry." Journal of AOAC INTERNATIONAL 95, no. 3 (2012): 923–31. http://dx.doi.org/10.5740/jaoacint.11-362.

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Abstract We developed a rapid and efficient means of determining residues of four nitroimidazoles—i.e., dimetridazole, ipronidazole, metronidazole, and ronidazole—and three hydrophilic metabolites—i.e., 2-hydroxymethyl-1-methyl-5-nitroimidazole, 1-methyl-2-(2′-hydroxyisopropyl)-5-nitroimidazole, and 1-(2-hydroxyethyl)-2-hydroxymethyl-nitroimidazole—in honey. We applied a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) procedure improved to suit a nitroimidazole analysis, which is fast (approximately 30 min) and uses less organic solvent. The procedure involves initial single-phase e

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2

Vichi-Ramírez, Micheel M., Edgar López-López, Catalina Soriano-Correa, and Carolina Barrientos-Salcedo. "Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review." Future Pharmacology 4, no. 1 (2024): 222–55. http://dx.doi.org/10.3390/futurepharmacol4010015.

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Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs. Additionally, multi-resistant protozoan strains represent an important global emergency that must be addressed. For these reasons, global efforts are being made to identify new drug candidates that are capable of combating these kinds of diseases. This systematic review shows that 5-nitroimidazole derivatives have been successfully used against neglected tropical prot

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3

Panicucci, Rick, and Robert A. McClelland. "4,5-Dihydro-4,5-dihydroxyimidazoles as products of the reduction of 2-nitroimidazoles. HPLC assay and demonstration of equilibrium transfer of glyoxal to guanine." Canadian Journal of Chemistry 67, no. 12 (1989): 2128–35. http://dx.doi.org/10.1139/v89-331.

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An HPLC method has been employed to study the electrochemical reduction (mercury cathode at −800 mV with respect to calomel electrode) of the 2-nitroimidazole benznidazole (N′-benzyl-(2′-nitro-1′-imidazoyl)acetamide). The principal product of this reduction is the cyclic guanidinium ion 3c (protonated N′-benzyl-(2′-amino-4′,5′-dihydro-4′,5′-dihydroxy-1-imidazoyl)acetamide), which forms in a linear fashion as the nitroimidazole is reduced and accounts for 75% of the product upon completion of the reduction. To perform the HPLC analysis quantitatively an authentic sample of this product (isolate

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4

Gupta, Ria, Sumit Sharma, Rohit Singh, Ram A. Vishwakarma, Serge Mignani, and Parvinder Pal Singh. "Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview." Pharmaceuticals 15, no. 5 (2022): 561. http://dx.doi.org/10.3390/ph15050561.

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Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with antibacterial activity, which was later identified as Azomycin 1 (2-nitroimidazole) and remained in focus until now. This natural antibiotic was the starting point for synthesizing numerous analogs and regio-isomers, leading to several life-saving drugs and clinical candidates against a number of diseases, including infections (bacterial, viral, para

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Tamošiūnas, Vytautas, and Audrius Padarauskas. "Ultra performance liquid chromatography-tandem mass spectrometry for the determination of 5-nitroimidazoles and their metabolites in egg." Open Chemistry 7, no. 3 (2009): 267–73. http://dx.doi.org/10.2478/s11532-009-0008-0.

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AbstractAn ultra performance liquid chromatography (UPLC) coupled to tandem mass spectrometry (MS/MS) procedure was developed for the determination of five 5-nitroimidazoles (dimetridazole, ipronidazole, metronidazole, ronidazole and ternidazole) and three of their metabolites (1-methyl-2-hydroxymethyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole and 1-methyl-2-(2′-hydroxyisopropyl)-5-nitroimidazole) in egg matrices. Conditions for UPLC separation and electrospray ionization MS/MS in the positive ion mode were optimized. Samples were prepared by liquid-liquid extractio

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Baird, Ian R., Brian O. Patrick, Kirsten A. Skov, and Brian R. James. "Nitroimidazoles with a halogen-containing side-chain." Canadian Journal of Chemistry 96, no. 3 (2018): 299–310. http://dx.doi.org/10.1139/cjc-2017-0604.

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Syntheses are reported for: nine 2-nitroimidazoles, the abbreviated names all beginning with E, based on derivation from Etanidazole); five 2-methyl-5-nitroimidazoles (M compounds, derived from Metronidazole); and five 2-methyl-4-nitroimidazoles (labelled 2M4N compounds). The nitroimidazoles all have an amide side-chain at the N1 atom of the imidazole, with 17 of them containing one to five halogen atoms. The aim is to study compounds for comparison with EF5 (the number showing the presence of five F-atoms), a previously reported, pentafluoropropylacetamide derivative of 2-nitroimidazole that

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7

Farah, Salim F., Robert A. McClelland, Michael R. Peterson, and Imre G. Csizmadia. "Molecular structure and relative proton and electron affinities of isomeric nitroimidazoles." Canadian Journal of Chemistry 67, no. 10 (1989): 1666–71. http://dx.doi.org/10.1139/v89-255.

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The isomeric 2-nitro, 4-nitro, and 5-nitroimidazoles have been studied in their planar ground state, C—NO2 rotational transition state, 3-H protonated conjugate acid and radical anion forms, with abinitio computations at the split-valence 3-21G basis set level. The stabilities of the parent compounds follow the order 5-NO2 ~ 4-NO2 > 2-NO2. In solution 4-nitro is more stable than 5-nitro; the calculations suggest that this is a solvation effect, since the 4-nitro isomer has a considerably higher dipole moment. Barriers for nitro group rotation range from 10 to 16 kcal/mol. However, the relat

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Kulkarni, S., MR Grimmett, LR Hanton, and J. Simpson. "Nucleophilic Displacements of Imidazoles. I. Oxygen, Nitrogen and Carbon Nucleophiles." Australian Journal of Chemistry 40, no. 8 (1987): 1399. http://dx.doi.org/10.1071/ch9871399.

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4(5)- Bromo - and - iodo-imidazoles, activated by an adjacent nitro substituent, undergo nucleophilic displacement with methoxide, phenoxide , cyclic secondary chines and cyanide. The regiochemistry of the reactions of 5-iodo-4-nitroimidazole with methoxide has been confirmed by spectroscopic and X-ray methods, and a number of erroneous structures from the literature have been revised. Some apparently anomalous reactions of methoxide with 5-halo-1,2-dimethyl-4- nitroimidazoles, and of cyanide with 4-halo-1-methyl-5-nitroimidazole have been noted. The crystal and molecular structure of 5-methox

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Pyka-Pająk, Alina. "TLC–Densitometric Analysis of Selected 5-Nitroimidazoles." Processes 11, no. 1 (2023): 170. http://dx.doi.org/10.3390/pr11010170.

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Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method to evaluate the chemical stability of metronidazole, secnidazole, ornidazole, and tinidazole under stress conditions. A forced degradation study was performed on silica gel and aqueous solutions at various pH values; the metronidazole, secnidazole, ornidazole, and tinidazole solutions were prepared in saline and in hydrogen peroxide, respectively. The samples of the 5-nitroimidazoles were heated. TLC analyses were performed on silica ge

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SALAMANCA M., Constain, William TIZNADO V., and Paula JARAMILLO G. "EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES." Vitae 17, no. 2 (2010): 199–208. http://dx.doi.org/10.17533/udea.vitae.6345.

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In this work we realized and experimental and theoretical study of the N-alkylation of nitroimidazoles.The N-alkyl-2-methyl-nitroimidazoles correspond to biologically active molecules, obtained by reactionof 2-methyl-5-nitroimidazole and different alkyl halides. This reaction showed the formation of a mixtureof isomeric products in different proportions, denominated like N-alkyl-2-methyl-4-nitroimidazole andN-alkyl-2-methyl-5-nitroimidazole, respectively. The reaction suggestes the formation of a tautomericequilibrium, which generates two nucleophilic sites susceptible to electrophilic attack

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Dissertations / Theses on the topic "5-nitroimidazoles"

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Zink, Laura. "Synthèse de dérivés 5-nitroimidazoles à potentialités anti-infectieuses." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5506/document.

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L'objectif de ce travail consiste en la synthèse de nouveaux 5-nitroimidazoles fonctionnalisés à visée thérapeutique. Dans un premier temps, l'étude de la réactivité du 4-bromo-1,2-diméthyl-5-nitro-1H-imidazole vis-à-vis du couplage de Suzuki-Miyaura sous irradiation micro-ondes a permis la synthèse de nouveaux produits substitués en position 4 par différents groupements aryle ou styryle. Dans un second temps, la réactivité LD-SRN1 a été étudiée entre le 4-[4-(chlorométhyl)phényl]-1,2-diméthyl-5-nitro-1H-imidazole et différents nucléophiles centrés sur l'atome de carbone ou de soufre. Cette ét

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Zink, Laura. "Synthèse de dérivés 5-nitroimidazoles à potentialités anti-infectieuses." Electronic Thesis or Diss., Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5506.

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L'objectif de ce travail consiste en la synthèse de nouveaux 5-nitroimidazoles fonctionnalisés à visée thérapeutique. Dans un premier temps, l'étude de la réactivité du 4-bromo-1,2-diméthyl-5-nitro-1H-imidazole vis-à-vis du couplage de Suzuki-Miyaura sous irradiation micro-ondes a permis la synthèse de nouveaux produits substitués en position 4 par différents groupements aryle ou styryle. Dans un second temps, la réactivité LD-SRN1 a été étudiée entre le 4-[4-(chlorométhyl)phényl]-1,2-diméthyl-5-nitro-1H-imidazole et différents nucléophiles centrés sur l'atome de carbone ou de soufre. Cette ét

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3

TRINH, STEPHANIE. "Etude genetique de la resistance aux 5-nitroimidazoles chez les bacteroides spp." Paris 6, 1996. http://www.theses.fr/1996PA066715.

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Des souches de bacteroides spp. Presentant une resistance moderee aux 5-nitroimidazoles ont recemment ete isolees en clinique. La majorite d'entre elles possedent des genes de resistance specifiques (designes nim) qui sont portes soit par de petits plasmides, soit par le chromosome. L'analyse de quatre de ces genes ayant revele une forte homologie nucleotidique, suggere qu'ils appartiennent a une meme famille. L'activation de ces genes est sous le controle de promoteurs internes a des sequences d'insertion specifiques des bacteroides, localisees en amont des genes. Un test de detection des gen

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4

Metayer, Olivier. "Analyse du mécanisme biochimique de la résistance des Bactéroides aux 5-Nitroimidazoles." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2P070.

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5

Pasupuleti, Vinay, Angel Arturo Escobedo, Abhishek Deshpande, Priyaleela Thota, Yuani Roman, and Adrian V. Hernández. "Efficacy of 5-Nitroimidazoles for the Treatment of Giardiasis: A Systematic Review of Randomized Controlled Trials." Public Library of Science (PLoS), 2014. http://hdl.handle.net/10757/316481.

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Background: Giardiasis is one of the most common causes of diarrheal disease worldwide and 5-nitroimidazoles (5-NI) are the most commonly prescribed drugs for the treatment of giardiasis. We evaluated the efficacy of 5-nitroimidazoles (5-NI) in the treatment of giardiasis in a systematic review of randomized controlled trials (RCTs). Methodology/Principal Findings: We conducted a comprehensive literature search in PubMed-Medline, Scopus, Web of Science and Cochrane Library for RCTs evaluating the efficacy of 5-NI vs. control (placebo or active treatment) on parasitological cure in patient

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6

Benakli, Kamel. "Synthèse de nouveaux agents pharmacologiques par réactions de transfert monoélectronique en série 5-nitroimidazole et quinoxaline." Aix-Marseille 3, 1999. http://www.theses.fr/1999AIX30043.

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Ce travail est consacre a la synthese par reactions de transfert monoelectronique de nouveaux agents pharmacologiques. La premiere partie decrit la preparation de nouveaux derives bis-alkylants nitroaromatiques et heterocycliques et l'etude de leur reactivite dans des reactions de c-alkylation avec l'anion du 2-nitropropane. La sensibilite de ces reactions aux inhibiteurs des reactions de substitution par transfert monoelectronique a permis de definir un mecanisme radicalaire en chaine bis-s#r#n1 en series 5-nitroimidazole, p-nitrobenzyle et quinoxaline. L'extension a divers anions nitronates,

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7

Haggoud, Abdellatif. "Aspects épidémiologique génétique et moléculaire de la résistance aux 5-nitroimidazoles chez les bactéroi͏̈des du groupe Fragilis." Paris 11, 1993. http://www.theses.fr/1993PA114841.

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8

Mathias, Fanny. "Synthèse et évaluation biologique de nouveaux nitroimidazoles : challenges et recherche de nouvelles relations structure-activité." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0591/document.

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Ce travail de thèse est consacré à la synthèse et l’évaluation biologique de nouveaux nitromidazoles à potentialités anti-infectieuses. Dans les trois premiers chapitres, nous avons abordé les propriétés biologiques des 5-nitroimidazoles, et la synthèse de nouveaux composés fonctionnalisés en positions 2 et 4 dans le but d'améliorer l'activité sur les souches résistantes au métronidazole, le 5-nitroimidazole de référence, tout en contrôlant au mieux la mutagénicité. Nous avons développé une méthode de couplage régiosélectif de Suzuki-Miyaura en position 4 du 2,4-dibromo-1-méthyl-5-nitro-1H-imi

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9

Hart, Christopher J. "Identifying new compounds active against Giardia duodenalis." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/391055.

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Giardia are a genus of enteric pathogens consisting of at least six species (Monis et al. 2009), of which one, Giardia duodenalis, infects humans (Heyworth 2016). In addition to humans, G. duodenalis parasites infect other mammals, which may act as reservoirs for human infection (Traub et al. 2004; Yaoyu and Xiao 2011; Abeywardena et al. 2015; Sroka et al. 2015; Štrkolcová et al. 2015; Heyworth 2016). In humans Giardia infection can be asymptomatic, however all infected hosts shed cysts and can transmit parasites (Oliveira-Arbex et al. 2016; Figgatt et al. 2017). Giardia infection can cause gi

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10

Mathias, Fanny. "Synthèse et évaluation biologique de nouveaux nitroimidazoles : challenges et recherche de nouvelles relations structure-activité." Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0591.

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Ce travail de thèse est consacré à la synthèse et l’évaluation biologique de nouveaux nitromidazoles à potentialités anti-infectieuses. Dans les trois premiers chapitres, nous avons abordé les propriétés biologiques des 5-nitroimidazoles, et la synthèse de nouveaux composés fonctionnalisés en positions 2 et 4 dans le but d'améliorer l'activité sur les souches résistantes au métronidazole, le 5-nitroimidazole de référence, tout en contrôlant au mieux la mutagénicité. Nous avons développé une méthode de couplage régiosélectif de Suzuki-Miyaura en position 4 du 2,4-dibromo-1-méthyl-5-nitro-1H-imi

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Book chapters on the topic "5-nitroimidazoles"

1

Dubreuil, L. "5-Nitroimidazoles." In Antimicrobial Agents. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815929.ch34.

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2

Moreno, Silvia N. J., and Roberto Docampo. "Reduction of 5-Nitroimidazoles, Nitrofurazone, and 2,4-Dinitrophenol to their Free Radical Metabolites by Tritrichomonas Foetus Hydrogenosomes." In Oxygen Radicals in Biology and Medicine. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5568-7_120.

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Crozet, M. P., O. Jentzer, and P. Vanelle. "Synthesis of New 5-Nitroimidazoles Highly Active Against Anaerobes by Substitution Reactions which Proceed via Radical and Radical-Anion Intermediates." In Free Radicals in Synthesis and Biology. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0897-0_25.

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4

Reysset, Gilles, Wen-Jin Su, and Madeleine Sebald. "Genetics of 5-Nitroimidazole Resistance in Bacteroides." In Brock/Springer Series in Contemporary Bioscience. Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4615-7087-5_37.

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Miwa, Gerald T., Peter Wislocki, Edward Bagan, Regina Wang, John S. Walsh, and Anthony Y. H. Lu. "Studies on the Mechanism of Activation and the Mutagenicity of Ronidazole, a 5-Nitroimidazole." In Biological Reactive Intermediates III. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5134-4_50.

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Wiebe, L. I., D. C. Jette, J. D. Chapman, R. J. Flanagan, and B. E. Meeker. "Iodoazomycin Riboside [l-(5′-iodo-5′- deoxyribofuranosyl)-2-nitroimidazolel, a Hypoxic Cell Marker In Vivo Evaluation in Experimental Tumors." In Nuclear Medicine in Clinical Oncology. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70947-0_59.

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"Antibacterial Agents That Cause DNA Damage in Obligate Anaerobic Organisms 5-Nitroimidazoles." In Bacteria versus Antibacterial Agents. ASM Press, 2014. http://dx.doi.org/10.1128/9781555817794.ch24.

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Jenks, Peter J. "Nitroimidazoles." In Antibiotic and Chemotherapy. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-7020-4064-1.00024-5.

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MIWA, GERALD T., REGINA WANG, RAUL ALVARO, JOHN S. WALSH, and ANTHONY Y. H. LU. "THE METABOLIC ACTIVATION OF RONIDAZOLE [(1-METHYL-5-NITROIMIDAZOLE-2-YL)-METHYL CARBAMATE] TO REACTIVE METABOLITES BY MAMMALIAN, CECAL BACTERIAL AND T. FOETUS ENZYMES." In Bioreduction in the Activation of Drugs. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-032030-4.50012-6.

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Conference papers on the topic "5-nitroimidazoles"

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Graves, K., J. Sharma, C. Reily, W. Secor, J. Novak, and C. Muzny. "P213 Identification of Trichomonas vaginalis 5-nitroimidazole resistance targets to inform future drug development." In Abstracts for the STI & HIV World Congress, July 14–17 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/sextrans-2021-sti.301.

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Hosmane, Ramachandra, Saika Siddiqui, and Bruce Gustafson. "A New Synthetic Approach toward Ring-Expanded ("Fat") Purine Nucleobases: Synthesis and Use of 5-Dichloromethyl-1-p-methoxybenzyl-4-nitroimidazole as a Versatile Intermediate." In The 3rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1999. http://dx.doi.org/10.3390/ecsoc-3-01740.

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