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Relevant bibliographies by topics / 5-substituted-amino derivatives

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Academic literature on the topic '5-substituted-amino derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "5-substituted-amino derivatives"

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Yang, Minmin, and Stewart W. Schneller. "Amino substituted derivatives of 5′-amino-5′-deoxy-5′-noraristeromycin." Bioorganic & Medicinal Chemistry 13, no. 3 (February 2005): 877–82. http://dx.doi.org/10.1016/j.bmc.2004.10.031.

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Konečný, Václav, Jozefína Žúžiová, Štefan Kováč, and Tibor Liptaj. "Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 800–808. http://dx.doi.org/10.1135/cccc19970800.

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Substituted 4-amino-2-phenyl-2H-pyridazin-3-ones 5a-5j have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one 1 which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative 2 or 4-diacetylamino derivative 3, respectively. Derivatives 2 and 3 with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones 4a-4j. Subsequent alkaline hydrolysis of the acetylamino derivatives 4a-4j let to the title compounds 5a-5j, which were screened for pesticidal activity, but none of them reached activity of the used standards.

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Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 42–51. http://dx.doi.org/10.1155/2005/542938.

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p- Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j)]. Further, these derivatives [1(a-j)] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j)], on condensation with 4 , 4’ - diamino diphenyl methane gives corresponding substituted imidazolinone - dibenzmethane derivatives [3(a-j)], on condensation with 4,4’- diamino benzanilide gives corresponding substituted imidazolinone - benzanilide derivatives [4(a-j)] and on condensation with 2 - amino pyridine gives corresponding substituted imidazolinone - pyridine derivatives [5(a-j)] respectively. Structure elucidation of synthesised compounds has been made on the basis of elemental analysis, I.R. spectral studies and1H N.M.R. spectral studies. The antimicrobial activity of the synthesised compounds has been studied against the cultures “Staphylococcus aureus”, “Escherichia coli” and “Candela albicans”.

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Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.

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1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation withp–amino acetophenone gives 1-[acetyl] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative. This derivative undergo condensation with 2,4- dichloro benzaldehyde gives 1- [3” - (sub. phenyl) - 2” - propene - 1” - one] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative which on reaction with 99% hydrazine hydrate and glacial acetic acid gives 1-[acetyl]-3- [1’ , 2’ - (dichloro) - dibenz sulphonamide] -5 - [2” , 4” - dichloro phenyl] - 2 - pyrazoline derivative. This derivative reacts with various substituted aldehydes to give corresponding substituted chalcone derivatives [1(a-j)]. Now, these chalcone derivatives [1(a-j)] on condensation with urea gives corresponding substituted pyrimidine - 2 - one derivatives [2(a-j)] and on condensation with thio-urea gives corresponding substituted pyrimidine- 2 -thione derivatives [3(a-j)]. Further, these chalcone derivatives [1(a-j)] on reaction with 99% hydrazine hydrate gives 1 - [1’ - (H) - 5’ - (sub. phenyl) - 2’ - pyrazoline]- 3 - [1” , 2” - (dichloro) - dibenz sulphonamide] - 5 - [2’’’ , 4’’’ - dichloro phenyl]-2- pyrazoline derivatives [4(a-j)] as an intermediate compounds, which on condensation with p-acetanilide sulphonyl chloride gives corresponding substituted p - acetanilide sulphonyl derivatives [5(a-j)] and on condensation with benzoyl chloride gives corresponding substituted benzoyl derivatives [6(a-j)]. Structure elucidation of synthesised compounds has been made on the basis of elemental analysis, I.R. spectral studies and 1H N.M.R. spectral studies. The antimicrobial activity of the synthesised compounds has been studied against the cultures “Staphylococcus aureus”, “Escherichia coli” and “Candela albicans”.

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El-Naggar, Mohamed, Abdel-Nasser El-Shorbagi, Dina H. Elnaggar, Abd El-Galil E. Amr, Mohamed A. Al-Omar, and Elsayed A. Elsayed. "Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates." Journal of Chemistry 2018 (November 1, 2018): 1–9. http://dx.doi.org/10.1155/2018/3626824.

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A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives 6a–h, 7a,b, and 8a,b. All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence.

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Lahsasni, Siham, Dunya A. M. Al-Hemyari, Hazem A. Ghabbour, Yahia Nasser Mabkhoot, Fadilah S. Aleanizy, Asma A. Alothman, and Zainab M. Almarhoon. "Synthesis, Characterization, and Antibacterial and Anti-Inflammatory Activities of New Pyrimidine and Thiophene Derivatives." Journal of Chemistry 2018 (August 1, 2018): 1–11. http://dx.doi.org/10.1155/2018/8536063.

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Substituted[4,5]thieno[2,3-d]thiazolo[3,2-a]pyrimidin-5-one (3a–b) and pyrimidin-5(6H)-imine (3c–e) were synthesized via reaction of the starting compounds, ethyl 2-amino-substituted[b]thiophene-3-carboxylate (2a–c) and 2-amino-substituted [b]thiophene-3-carbonitrile (2d–f), respectively, with 2-bromothiazole. Synthesis of (bromo-substituted[b]thiophen-2-yl)alkanamide derivatives (4a–e) and thieno[2,3-d][1,3]oxazin-4-imine derivative (5) was accomplished via reaction of the starting compounds with bromoalkyl chloride through nucleophilic substitution; however, for the synthesis of compound 5, nucleophilic substitution was followed by nucleophilic addition to a nitrile group to form the oxazinimine ring. 1-(3-cyano-substituted[b]thiophen-2-yl)-3-(4-(trifluoromethyl)phenyl)thiourea derivatives (6a–c) were obtained via reaction of the starting compounds (2d–f) and 4-(trifluoromethyl phenyl)isothiocyanate. The lead compounds (2d–f) rapidly reacted with 4-(trifluoromethyl)benzaldehyde or 4-(2-pyridyl)benzaldehyde in acidic medium to yield compounds (7a–f) in large quantities. X-ray crystallography of compounds 4c and 7e confirmed their structures. Antimicrobial studies revealed that compound 6a was equally potent to ampicillin against Bacillus strains. Moreover, compounds 3e, 4d, and 6a possessed greater anti-inflammatory potency than that of the standard drug.

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Hussain, Sabir, Jyoti Sharma, and Mohd Amir. "Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid." E-Journal of Chemistry 5, no. 4 (2008): 963–68. http://dx.doi.org/10.1155/2008/924734.

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Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity againstS. aureus(gram-positive) andE.coli(gram-negative) bacteria and antifungal activity againstA. nigerfungi using cup plate technique

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Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

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The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4-arenecarbonylmethylthio derivatives were recovered unchanged from such hydrolysis reactions.

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9

Janeba, Zlatko, Antonín Holý, and Milena Masojídková. "Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purine-8(9H)-thione and 8-(Methylsulfanyl)adenine." Collection of Czechoslovak Chemical Communications 65, no. 11 (2000): 1698–712. http://dx.doi.org/10.1135/cccc20001698.

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Reaction of 8-bromoadenine derivatives 1 with thiourea in ethanol or butanol was used for the synthesis of the corresponding N9-substituted 6-amino-7H-purine-8(9H)-thiones 2. 8-(Methylsulfanyl)adenine derivatives 3 were prepared by reaction of thiones 2 with iodomethane in 1 M sodium methoxide or in aqueous 1.5 M potassium hydroxide. Alkylation of 6-amino-7H-purine-8(9H)-thione (2a) proceeds preferentially on the sulfur atom. Under similar conditions, alkylation of 8-(methylsulfanyl)adenine (3a) with diverse alkylation agents afforded N9-substituted adenine derivatives 3 and 6, and N3-substituted adenine derivatives 5 and 7. 8,3'-S-Anhydro derivatives 9 were prepared in good yields by cyclization of 6-amino-7H-purine-8(9H)-thiones 2d and 2f under the Mitsunobu reaction conditions.

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10

Prokopenko, V. M., S. G. Pil’o, and V. S. Brovarets. "Synthesis of 4-hetaryl-substituted 5-amino- and 5-sulfanyl-1,3-oxazole derivatives." Russian Journal of General Chemistry 81, no. 2 (February 2011): 405–10. http://dx.doi.org/10.1134/s1070363211020204.

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Book chapters on the topic "5-substituted-amino derivatives"

1

Mmonwa, Mmakwena M., and Malose J. Mphahlele. "2-Amino-5-Bromo-3-Iodoacetophenone and 2-Amino-5-Bromo-3-Iodobenzamide as Synthons for Novel Polycarbo-Substituted Indoles and Their Annulated Derivatives." In Emerging Trends in Chemical Sciences, 391–404. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60408-4_23.

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2

Angulwar, Jaman A. "Multicomponent Synthesis of 2-Substituted Derivatives of 6-Amino-5-Cyano-1,4-Dihydro-3-Methyl-1,4-Diphenylpyrano-[2,3-C]-Pyrazole Using Knoevenagel and Michael Addition." In Modern Green Chemistry and Heterocyclic Compounds, 113–36. Series statement: Innovations in physical chemistry: monographic series: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-4.

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3

Harris, P. A. "10.24.4 Product Subclass 4: Pyrazino[1,2-a]indoles and Related Benzo-Fused Ring Systems." In Science of Synthesis: Knowledge Updates 2021/3. Stuttgart: Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/sos-sd-110-02056.

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AbstractThe synthesis of pyrazino[1,2-a]indoles and related indolo[1,2-a]quinoxalines and pyrido[2′,1′:3,4]pyrazino[1,2-a]indol-5-ium salts are reviewed in this chapter. The most common routes to pyrazino[1,2-a]indoles involve cyclization of indole derivatives containing a formyl, keto, ester, or nitrile function at the 2-position. Indolo[1,2-a]quinoxalines are most readily accessed via cyclization of 1-(aryl)-1H-indoles, where the aryl group is substituted at the 2-position by either amino, iodo, or nitro functionality.

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4

Taber, Douglass F. "Carbocyclic Ring Construction: The Nicolaou Synthesis of Myceliothermophin E." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0082.

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Nan Zheng of the University of Arkansas developed (Adv. Synth. Catal. 2014, 356, 2831) a Ru catalyst for the addition of an amino cyclopropane 1 to an alkyne 2 to give 3. The reaction proceeded with high regiocontrol, but only modest stereocontrol. Alain De Mesmaeker of Syngenta Crop Protection, Switzerland found (Tetrahedron Lett. 2014, 55, 6577) that the β,γ-unsaturated amide 4 worked particularly well as a precursor to the keteniminium that cyclized to give, after hydrolysis, the cyclobutanone 5. Baeyer–Villiger oxidation of 5 led to 5-deoxystrigol 6. David Tymann and Martin Hiersemann of the Technische Universität Dortmund have been exploring (Org. Lett. 2014, 16, 4062; Synthesis 2014, 46, 3110) the intramolecular carbonyl ene reaction as a tool for the assembly of highly substituted cyclopentanes, as in the conversion of 7 to 8. On oxidation, 8 was readily carried on to the alkene 9. James L. Leighton of Columbia University conceived (J. Am. Chem. Soc. 2014, 136, 9878) the cascade transformation of 10 to 12. Deprotonation/silylation set the stage for Claisen rearrangement to give 11. The subsequent Cope rearrangement is an equilibrium process, driven by the ring strain of 11. K. C. Nicolaou of Rice University described (Angew. Chem. Int. Ed. 2014, 53, 10970) the total synthesis of the cytotoxic tetramic acid derivative myceliothermophin E 15. A key step in the synthesis was the intramolecular Michael addition/ aldol condensation that converted 13 to 14.

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Conference papers on the topic "5-substituted-amino derivatives"

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Nikalje, Anna Pratima, Shailee Tiwari, Sumaiya Siddiqui, and Julio Seijas Vázquez. "Microwave-assisted Facile Synthesis And Anticancer Evaluation Of N-((5-(substituted Methylene Amino)- 1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a010.

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Giannini, Giuseppe, Walter Cabri, Tiziana Brunetti, Andrea Ciacci, Daniele Simoni, Riccardo Baruchello, Giuseppina Grisolia, et al. "Abstract 731: 4-Amino-substituted 5-resorcinol-isoxazole derivatives, a novel class of Hsp90 inhibitor: Synthesis and evaluation of in vitro activity." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-731.

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Messaïkeh, H., N. Belattar, D. Gulino, J. Jozefonvicz, and Y. Sultan. "REMOVAL OF HUMAN ANTIBODIES TO FACTOR VIII :C FROM HEMOPHILIAC PLASMA USING NEW SYNTHETIC SORBENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644716.

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Human antibodies that neutralize factor VIII procoagulant activity (Anti VIII:C) detected in polytransfused patients with hemophilia A cause serious difficulties for the affected patients as they inactivate any injected FVIII preparations.We hypothesized that FVIII:C might possess active sequences composed of amino acids able to bind Anti VIII:C antibodies. Consequently, completely synthetic resins with suitable chemical substituents mimicking these sequences might interact with Anti VIII:C antibodies. Based upon this hypothesis, crosslinked polystyrene was substituted by various amino acids or their derivatives in order to obtain completely synthetic adsorbents able to remove Anti VIII:C antibodies from hemophiliac plasmas. To establish the relationship between chemical composition of the resins and their affinity towards Anti VIII:C antibodies, the "in vitro" removal of these inhibitors from hemophiliac1s immunoglobulins G was tested by measuring simultaneous adsorptions of either IgG or Anti VIII:C antibodies. Specific and accurate methods veil adapted for studying the adsorption of these two kinds of proteins were used for evaluating either the IgG concentrations (rocket iirrnunoelectrophoresis) or the Anti VIII:C concentrations (immunoradicmetric method). To determine the most suitable chemical groups able to develop a specific adsorption, a first screening on amino acid substituents was undertaken and allowed the selection of glutamic acid and hydro -xyproline. In fact, among the twenty resins tested, the most interesting one is obtained by linking glutamic dimethyl ester derivative onto the polystyrene matrix. This resin possesses a pseudo-specificity towards Anti VIII :C antibodies as it is possible to remove 12 % of Anti VIII :C antibodies and only 3 % of IgG on 5 mg of this resin. Furthermore, the hydrophobic sites on the surface seems to be involved in the Anti VIII :C adsorption as demonstrated by comparing selectivity obtained with mono and diester derivatives either in aspartic or glutamic series.

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Nikalje, Anna Pratima, Julio Seijas Vázquez, Shailee Tiwari, and Zahid Zaheer. "Ultrasound-promoted One-Pot, Three Component Synthesis Of Novel 5-Amino-2-(4-Chlorophenyl)-7- Substituted Phenyl-8,8a-Dihydro-7H-[1,3,4]Thiadiazolo[3,2-A]Pyrimidine-6-Carbonitrile Derivatives." In The 19th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a048.

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