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1

Lou, Ben Lin, Yuan Yuan Li, and Ru Xiao. "Preparation and Characterization of Polyacrylonitrile in Aqueous Slurry Polymerization." Materials Science Forum 789 (April 2014): 215–17. http://dx.doi.org/10.4028/www.scientific.net/msf.789.215.

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Polyacrylonitrile (PAN) is widely used for its superior properties, and comonomers are usually introduced to improve its properties. In this paper, 2-acrylamide-2-methylpropanesulfonic acid (AMPS) and acrylamide (AM) were used as comonomers to prepare polyacrylonitrile by aqueous slurry polymerization. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) was used to characterize the chemical structures, the thermal properties, degree of crystallinity of polyacrylonitrile copolymer. The results show that the best thermal property of
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2

Bajetta, Emilio, Laura Catena, Sara Pusceddu, et al. "Everolimus in Combination with Octreotide Long-Acting Repeatable in a First-Line Setting for Patients with Neuroendocrine Tumors: A 5-Year Update." Neuroendocrinology 106, no. 4 (2017): 307–11. http://dx.doi.org/10.1159/000479587.

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Background: We previously presented data of this multicentric, phase II study showing that everolimus plus octreotide long-acting repeatable (LAR) for advanced neuroendocrine neoplasms (NENs), in the first line setting, is an active and safe treatment. We now present updated data at 5 years. Methods: Patients with advanced well-differentiated, previously untreated neuroendocrine tumors of the gastroenteropancreatic tract and of the lung received octreotide LAR 30 mg plus everolimus 10 mg/day. The primary endpoint was the objective response rate (ORR). We performed an analysis of “long responde
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3

Pertseva, N. O., and K. I. Moshenets. "Definition of the dependence of QTc interval prolongation on glycemic control in patients with type 2 diabetes mellitus." Medicni perspektivi 27, no. 1 (2022): 58–64. http://dx.doi.org/10.26641/2307-0404.2022.1.254326.

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The aim of the study: to assess the impact of glycemic variability on the duration of QTc interval in patients with diabetes mellitus type 2. 68 patients with type 2 diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c) level ≤10% were examined. Of them – 37 (54.4%) men and 31 (45.6%) women. The average age – 46.0 (43.0; 54.0) years, the duration of DM type 2 – 7.0 (5.0; 9.0) years. Patients were divided into 2 groups according to HbA1c level: group 1 (n=31) with HbA1c <7% and group 2 (n=37) with HbA1c ≥7%. The control group consisted of 10 practically healthy people, compared by gende
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Pertseva, N.O., and K.I. Moshenets. "Definition of the dependence of QTc interval prolongation on glycemic control in patients with type 2 diabetes mellitus." Medicni perspektivi 27, no. 1 (2022): 58–64. https://doi.org/10.26641/2307-0404.2022.1.254326.

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The aim of the study: to assess the impact of glycemic variability on the duration of QTc interval in patients with diabetes mellitus type 2. 68 patients with type 2 diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c) level ≤10% were examined. Of them – 37 (54.4%) men and 31 (45.6%) women. The average age – 46.0 (43.0; 54.0) years, the duration of DM type 2 – 7.0 (5.0; 9.0) years. Patients were divided into 2 groups according to HbA1c level: group 1 (n=31) with HbA1c <7% and group 2 (n=37) with HbA1c ≥7%. The control group consisted of 10 practically heal
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5

Wang, Siyue, Yang Hu, Binkai Liu, Yanping Li, Molin Wang, and Qi Sun. "Lignan Intake and Type 2 Diabetes Incidence Among US Men and Women." JAMA Network Open 7, no. 8 (2024): e2426367. http://dx.doi.org/10.1001/jamanetworkopen.2024.26367.

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ImportanceLignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.ObjectiveTo prospectively investigate associations between lignan intake and T2D incidence.Design, Setting, and ParticipantsPopulation-based cohort study of US men and women enrolled in the Nurses’ Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well as 496 participants from the Men’s Lifestyle Validation Study (MLVS). Participants were free of T2D, cardiovascular disease, and cancer at baseline. Data were analyzed
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Travnicek, J., V. Kroupova, I. Herzig, and J. Kursa. "Iodine content in consumer hen eggs." Veterinární Medicína 51, No. 3 (2012): 93–100. http://dx.doi.org/10.17221/5526-vetmed.

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This paper presents the latest information about the supply of iodine to meet its requirements in hens of laying type, on the basis of iodine content in egg yolk and about the importance of eggs as an iodine source in human nutrition. The Sandell-Kolthoff method was applied to determine iodine content in the yolk of eggs from 9 large flocks (54 eggs) and 16 small flocks (96 eggs) in 2004, and from 10 large flocks (135 eggs) and 15 small flocks (114 eggs) in 2005. Iodine content was also determined in the albumen of 70 eggs. In 2004, the iodine content in the yolk of eggs from large fl
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7

ZIEGLER, THOMAS, TRUONG QUANG NGUYEN, CUONG THE PHAM, et al. "Three new species of the snake genus Achalinus from Vietnam (Squamata: Xenodermatidae)." Zootaxa 4590, no. 2 (2019): 249. http://dx.doi.org/10.11646/zootaxa.4590.2.3.

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Three new species of the xenodermatid genus Achalinus are described from northern Vietnam based on morphological and molecular evidence: Achalinus juliani sp. nov. is characterized by a combination of the following characters: 1) maxillary teeth 28; 2) suture between the internasals distinctly longer than that between the prefrontals; 3) internasal not fused to prefrontal; 4) loreal not fused with prefrontal; 5) infralabials 6; 6) mental separated from anterior chin shields; 7) two elongated anterior temporals, in contact with the eye, and two posterior temporals; 8) dorsal scales in 25–23–23
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8

John, J., and M. S. Malchijah Raj. "Graphs with large Steiner number." Ukrains’kyi Matematychnyi Zhurnal 76, no. 5 (2024): 719–27. http://dx.doi.org/10.3842/umzh.v76i5.7409.

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UDC 519.1 In 2002, Gary Chartrand and Ping Zhang [<em>The Steiner number of a graph,</em> Discrete Math., <strong>242</strong>, 41--54 (2002)] characterized the connected graphs G of order p ≥ 3 with Steiner number p , p - 1 , or 2. In our paper, we characterize all connected graphs G of order p ≥ 4 with Steiner number s ( G ) = p - 2 . In addition, we obtain some sharp Nordhaus–Gaddum bounds for the Steiner number of connected graphs whose complement is also connected.
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9

O'Bryant, Kevin. "On the size of finite Sidon sets." Ukrains’kyi Matematychnyi Zhurnal 76, no. 8 (2024): 1192–206. http://dx.doi.org/10.3842/umzh.v76i8.7858.

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UDC 519.1 A Sidon set (also called a Golomb ruler) is a B 2 sequence and a 1 -thin set is a set of integers containing no nontrivial solutions to the equation a + b = c + d . We improve the lower bound for the diameter of a Sidon set with k elements, namely, if k is sufficiently large and 𝒜 is a Sidon set with k elements, then ⅆ i a m ( 𝒜 ) ≥ k 2 - 1.99405 k 3 / 2 . Alternatively, if n is sufficiently large, then the cardinality of the largest subset of { 1,2 , … , n } , which is a Sidon set, does not exceed n 1 / 2 + 0.99703 n 1 / 4 .
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10

Makarov, V. L., N. V. Mayko та V. L. Ryabichev. "Реалізація точних триточкових різницевих схем для системи звичайних диференціальних рівнянь 2-го порядку". Ukrains’kyi Matematychnyi Zhurnal 75, № 1 (2023): 72–95. http://dx.doi.org/10.37863/umzh.v75i1.7373.

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УДК 517.9 + 519.6 Досліджено точну триточкову різницеву схему (ТТРС) для системи звичайних диференціальних рівнянь 2-го порядку з крайовими умовами першого роду. Знайдено послаблені умови (порівняно з відомими), за яких можливе перетворення ТТРС до однорідного дивергентного вигляду. Доведено теореми про коефіцієнтну стійкість і точність. Показано, що коефіцієнти ТТРС можна подати через розв'язки чотирьох задач Коші на проміжках довжини кроку сіт\-ки. Розв'язки цих задач можна одержати за допомогою будь-якого однокрокового методу, що приводить до усіченої різницевої схеми відповідного рангу.
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11

Rahman, Md Mahfuzur, and Md Abid Hasan. "Screening of carrot lines for quality roots and higher yield for commercial cultivation." Research in Agriculture Livestock and Fisheries 2, no. 1 (2015): 75–77. http://dx.doi.org/10.3329/ralf.v2i1.23031.

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The experiment was conducted at Research and Development (R&D) farm of Ispahani Agro LTD., Rangpur in order to screen suitable carrot lines for commercial cultivation in Bangladesh. Two hybrid lines (02001 and 02002) and four open pollinated lines (01001, 01002, 01003 and 01004) were used in this screening program. The experiment was carried out following randomized complete block design with three replications. Results showed that root length and diameter of line 01004 were 14.66 and 3.580 cm, respectively. The standard weight of 5 roots was 519.3 g. Moreover, the line 01004 showed maximu
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12

Zulkurnai, N. Z., U. F. Md. Ali, N. Ibrahim, and N. S. Abdul Manan. "Carbon Dioxide Capture by Deep Eutectic Solvent Impregnated Sea Mango Activated Carbon." E3S Web of Conferences 34 (2018): 02030. http://dx.doi.org/10.1051/e3sconf/20183402030.

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The increment amount of the CO2 emission by years has become a major concern worldwide due to the global warming issue. However, the influence modification of activated carbon (AC) has given a huge revolution in CO2 adsorption capture compare to the unmodified AC. In the present study, the Deep Eutectic Solvent (DES) modified surface AC was used for Carbon Dioxide (CO2) capture in the fixed-bed column. The AC underwent pre-carbonization and carbonization processes at 519.8 °C, respectively, with flowing of CO2 gas and then followed by impregnation with 53.75% phosphoric acid (H3PO4) at 1:2 pre
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13

Salik, M., M. Hanif, J. Wang, and X. Q. Zhang. "Spectroscopic characterization of laser-ablated manganese sulfate plasma." Laser and Particle Beams 32, no. 1 (2014): 137–44. http://dx.doi.org/10.1017/s0263034614000020.

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AbstractIn this work, we present the spectroscopic studies of the plasma generated at the surface of manganese sulfate by the fundamental (1064 nm) and second harmonic (532 nm) of a Q-switched Nd:YAG laser. The 4s4p 4F7/2→ 4s 2H9/2 at 438.80 nm, 4p 2I11/2 → 4s22I11/2 at 440.80 nm, 4p 4G11/2 → 4s 2H9/2 at 464.27 nm, 4p 4F5/2→ 4s 4D7/2 at 467.16, 4p 4F5/2 → 4s24G 7/2 at 515.08 nm, and 4p 4F7/2 → 4s2 4G 9/2 at 519.65 nm transitions have been used to estimate the electron temperature through the Boltzmann plot method. The number density has been estimated from the Stark broadened profiles of the s
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14

Starkova, A. V., Yu N. Karpenko, B. Ya Syropyatov, F. V. Sobin, and N. A. Pulina. "STUDY OF INFLUENCE OF BLOOD THIAZOLINE AMMONIUM 4-CHLOROPHENYL-2-HYDROXY-4-OXO-2-BUTENOATE CONCENTRATION ON ANTICOAGULANT EFFECT UPON SUBCUTANEOUS ADMINISTRATION." Perm Medical Journal 35, no. 1 (2018): 88–94. http://dx.doi.org/10.17816/pmj35188-94.

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Aim. To study the effect of blood thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate content on the manifestation of anticoagulant effect upon subcutaneous administration to rabbits. Materials and methods. The studies were fulfilled on outbred rabbits. The substance was administered subcutaneously in the dose of 35 mg/kg. The time of blood coagulation was determined using coagulometer “Minilab 701”, and blood concentration - by means of liquid micro-column chromatograph “Milichrom A-02”. Results. The obtained results prove that maximum concentration of the compound in blood and max
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Oh, Tak, Jung-Won Hwang, Young-Tae Jeon, and Sang-Hwan Do. "Perioperative Cumulative Fluid Balance and Its Association with an Increase in Costs after Major Surgery." Journal of Clinical Medicine 7, no. 9 (2018): 227. http://dx.doi.org/10.3390/jcm7090227.

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Positive fluid balance (FB) during the perioperative period may increase the incidence of postoperative complications, which may lead to longer hospitalization and higher hospital costs. However, a definitive association between positive FB and hospital costs has not yet been established. This retrospective observational study examined the association between perioperative FB and hospital costs of patients who underwent major surgical procedures. Medical records of patients who underwent major surgery (surgery time >2 h, estimated blood loss >500 mL) from January 2010 to December 2017 we
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Hamilton, Michael A., J. Javier Álvaro, Sandra M. Barr, et al. "U–Pb zircon ages from tuffaceous beds in the Terreneuvian to Cambrian Series 2 sections of Avalonian southern New Brunswick, Canada: new constraints on chronostratigraphic correlations and the Cambrian time scale." Geological Society, London, Special Publications 542, no. 1 (2023): 217–32. http://dx.doi.org/10.1144/sp542-2023-11.

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Abstract Avalonian sections in the Saint John area, southern New Brunswick, have long contributed to global understanding of Cambrian chronostratigraphy. A tuffaceous bed in the Ratcliffe Brook Formation (RBF) in the Somerset Street section dated at c. 531 Ma has traditionally been considered to post-date small shelly fossils attributed to the Watsonella crosbyi Zone in the Hanford Brook section. A fine-grained tuffaceous bed approximately 8 m stratigraphically lower in the Somerset Street section yields a chemical abrasion isotope dilution–thermal ionization mass spectrometry zircon age of 53
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Dedy Pratama, Hendro Sudjono Yuwono, Rudi Supriyadi, Herry Herman, Fachreza Aryo Damara, and Avicenna Akbar. "Antioxidant Properties of Curcumin and Its Impact on Arteriovenous Fistula Maturation in End-Stage Kidney Disease Patient with Diabetes Mellitus Type 2." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 7624–29. http://dx.doi.org/10.26452/ijrps.v11i4.4107.

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The risk of maturation failure in arteriovenous fistula (AVF) remains high. Curcumin poses antioxidant effects may enhance AVF maturation. This study evaluates the antioxidant effect of Curcumin on AVF maturation among type 2 diabetic patients (T2DM) with end-stage renal disease (ESRD). This was a single-blinded, randomized controlled trial conducted in three tertiary hospitals in Jakarta, Indonesia. Patients underwent the first hemodialysis. A total of 67 patients divided into groups of Curcumin, acetylsalicylic acid, and placebo. After 4 weeks, TAC level among the curcumin group was signific
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Zeng, Baimei, Ling Yuan, Jun Chu, Yanqing Yang, and Shide Lin. "Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review." Journal of International Medical Research 48, no. 3 (2019): 030006051989101. http://dx.doi.org/10.1177/0300060519891018.

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Early identification of the causes of cholestasis is important for appropriate management of patients with hyperthyroidism. We report a patient who had hyperthyroidism and severe cholestasis after methimazole (MMI) treatment. The patient was diagnosed as having MMI-induced cholestatic hepatitis. Treatment with MMI was stopped at admission to hospital. However, his serum total bilirubin (TBil) level rose from 410.5 µmol/L to 519.9 µmol/L and prothrombin time activity (PTA) dropped from 81.0% to 52.2% in 10 days. To prevent further deterioration of his liver function, plasma exchange was perform
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Colak, Yasar, Ebubekir Senates, Ender Coskunpinar, et al. "Concentrations of Connective Tissue Growth Factor in Patients with Nonalcoholic Fatty Liver Disease: Association with Liver Fibrosis." Disease Markers 33, no. 2 (2012): 77–83. http://dx.doi.org/10.1155/2012/283726.

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Aim:In this study, we aimed to investigate the relationship between the histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) to determine the usefulness of this relationship in clinical practice.Methods:Serum samples were collected from 51 patients with biopsy-proven NAFLD and 28 healthy controls, and serum levels of CTGF were assayed by ELISA.Results:Levels of CTGF were significantly higher in patients with NAFLD compared with controls (P= 0.001). The serum CTGF levels were significantly increased, that correlated with histol
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Kim, Young-Kyun, Yeun-Ah Joo, Tae-Shik Yoon, and Kee-Ahn Lee. "Effect of Fe-Cr-B on the Microstructure and Mechanical Properties of a Powder Injection Molding Processed Fe-Cr-B/316L Stainless Steel Matrix Composite." Korean Journal of Metals and Materials 61, no. 1 (2023): 9–17. http://dx.doi.org/10.3365/kjmm.2023.61.1.9.

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Stainless steel-based composites (SMCs) mixed with 316L stainless steel powder and Fe-Cr-B based M alloys powder ed M) powder were manufactured using the powder injection molding (PIM) process, and their microstructure and mechanical properties were investigated. To examine the effect of M content on the properties of SMCs, the M fraction was controlled to 30 vol.%, 50 vol.%, and 70 vol.%. It was observed that PIM-processed Fe-Cr-B/316L SMCs (30 vol.%, 50 vol.%, 70 vol.%) had γ-austenite and minor α-ferrite as a matrix, and (Cr, Fe)<sub>2</sub>B was formed as a reinforced phase. In
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Zurnadzhyants, V. A., E. A. Kchibekov, K. G. Gasanov, and A. A. Kchibekov. "Modern view in diagnosis of uremic pseudoperitonitis and peritonitis in patients on renal replacement therapy (programmed hemodialysis)." Perm Medical Journal 38, no. 4 (2021): 104–11. http://dx.doi.org/10.17816/pmj384104-111.

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Objective. Determination of blood serum 2-microglobulin and lactoferrin concentration in patients on renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pseudoperitonitis and peritonitis.
 Materials and methods. We examined 56 patients admitted to the Surgical Department of Astrakhan Clinical Hospital RZhD-Medicine and City Clinical Hospital № 3, and studied the concentration of blood serum 2-microglobulin and lactoferrin in patients urgently hospitalized with suspicion of uremic pseudoperitonitis or peritonitis, who receive renal replacement therapy (programme
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Bunder, S. J. "Growth and Yield of Wheat (Triticum aestivum L.) Affected by Yeast Extract and Ascorbic Acid." IOP Conference Series: Earth and Environmental Science 1449, no. 1 (2025): 012059. https://doi.org/10.1088/1755-1315/1449/1/012059.

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Abstract Field experiment was carried out at the Research Station of College of Agriculture Engineering Sciences, Baghdad University, during the 2022-2023 and 2023-2024 seasons, to study the effect of spraying yeast extract and ascorbic acid on the growth, grain yield, concentration ascorbic acid in leaves and seeds of bread wheat var. Rasheed to determine the most appropriate treatment to increase production efficiency. Factorial experiment was conducted in RCBD design with three replications were used with two factors, the first was yeast extract concentrations (0, 2, 4, 6, 8 g L−1), while t
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Belobrovaya, Olga Ya, Victor V. Galushka, Victoria S. Ismailova, et al. "Effect of Small Doses of Gamma Radiation on the Optical Properties of Nanostructured Silicon Obtained by Metal-Stimulated Chemical Etching in situ." Izvestiya of Saratov University. New series. Series: Physics 20, no. 4 (2020): 288–98. http://dx.doi.org/10.18500/1817-3020-2020-20-4-288-298.

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Background and Objectives: Porous silicon nanowires (SiNP) obtained by the method of metal stimulated chemical etching (EE method) are of great interest. The physical properties of this material depend significantly on the morphology of the nanostructures and their sizes. Given in the literature data on the effect of small doses of ionizing radiation on metals and alloys and the effect of irradiation on the properties of porous silicon and SiNP, makes sense to modify not only the substrate, but also the SiNP layer during its formation by irradiation. A change in the morphology of the formed la
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Daniels, Evan, Nur Wulandari, and Didah Nur Faridah. "Glycemic Index of Sweet Corn and the Characteristics of their Flakes by Adding the Red Bean." Jurnal Teknologi dan Industri Pangan 34, no. 2 (2023): 233–41. http://dx.doi.org/10.6066/jtip.2023.34.2.233.

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Consuming foods with a low glycemic index, such as sweet corn (Zea mays Saccharata), which has a high fiber content, can help lower the risk of diabetes. According to previous research, sweet corn is predicted to have a low glycemic index (GI). The study's goals were to determine the value of the glycemic index of corn and to produce low glycemic index instant flake products made from sweet corn and red beans. The glycemic index value of sweet corn was determined using a glycemic index test technique based on ISO 26642:2010E. The flakes was made with the addition of red beans reported to have
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Dorji, Jigme, Dhendup, and Iona M. MacLeod. "Phenotypic and genetic parameters for milk yield in traditional Nublang cattle (Bos indicus) of Bhutan." Animal Genetic Resources/Ressources génétiques animales/Recursos genéticos animales 57 (July 20, 2015): 25–30. http://dx.doi.org/10.1017/s2078633615000223.

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SummaryThe Nublang is a unique dual-purpose breed ofBos indicuscattle found in Bhutan. They have been crossed with Mithun (Bos frontalis) andBos taurusbreeds in an effort to improve milk production leading to a decline in the population of purebred Nublang. An alternative to crossbreeding would be the genetic improvement of milk yield within purebred Nublang, thus allowing conservation and sustainable utilization of the pure breed. It is important to measure the genetic variability (heritability) of milk yield to assess the potential for genetic improvement within Nublang. Therefore this study
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KILINÇ, Çetin, Melike YAŞAR DUMAN, Büşra ÇALIŞIR, et al. "Evaluation of anti-spike IgG response after inactivated COVID-19 vaccine in healthcare workers." Kastamonu Medical Journal 2, no. 4 (2022): 123–26. http://dx.doi.org/10.51271/kmj-0085.

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Aim: This study purposed to determine anti-spike IgG levels at the fourth week after the second dose in healthcare workers (HCWs) who had two doses of the CoronaVac vaccine (Sinovac Life Sciences, Beijing, China). The second purpose of the study was to evaluate several factors that may affect antibody levels.
 Material and Method: The study was performed at Kastamonu Training and Research Hospital. A total of 197 HCWs of both genders aged 20-63 were included in this study. Antibody levels that neutralize the SARS-CoV-2 spike protein S1 subunit were determined using the SARS-CoV-2 IgG II Q
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Joshi, J. R., S. Dhakal, and S. Kafle. "Performance of Wheat Genotypes Under Different Dates of Sowing in Southern Part of Kailali District, Nepal." American Journal of Life Science and Innovation 1, no. 1 (2022): 1–5. http://dx.doi.org/10.54536/ajlsi.v1i1.212.

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An experiment was conducted in the Kailali district to study the performance of wheat genotypes under different sowing from December, 2017 to April, 2018. The field experiment was conducted in Randomized Complete Block Design with a total of 18 treatments consisting of 2 dates of sowing (November 4 and November 20 ) and 9 wheat genotypes(WH1105, HD2733, HD2824, HD2967, Borlaug100, HD3086, PBW550, NL971 and PBW373). Grain yield (5.802 ton/ha),spike length(17.94 cm) and biomass yield(13.16 ton/ha) of NL 971 was highest. HD 2733 had highest number of effective tillers (519.1/ m2) while number of
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Cortés, Ariel Emilio, Oscar Realpe, María Isabel Fuerte, Paula Andrea Tello, and Carmen Elisa Becerra. "Contraceptives, chronic illness, pregnancy and health care costs in one health insurance in Colombia." Revista de Salud Pública 24, no. 2 (2022): 1–7. http://dx.doi.org/10.15446/rsap.v24n2.89316.

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Objetive Evaluation of the impact of pregnancy on women with a high disease burden, especially with Chronic Non-Communicable Diseases (CNCD) in the costs of a health insurer. Materials and Methods Retrospective costing study conducted at Famisanar EPS between 2016 and 2018. We used multiple linear regression models to evaluate; the overall costs were calculated for each patient. The insurer's perspective was taken into account for the analysis. Results The study universe was made up of 458 249 women of childbearing age affiliated to Famisanar EPS between 15 and 49 years, of which 24 030 (5.2%)
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Koguchi, Yoshinobu, Noriko Iwamoto, Takashi Shimada, et al. "760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A808. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0760.

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BackgroundImmune checkpoint blockade (ICB) using anti-CTLA-4 and anti-PD-1/PD-L1 has revolutionized the treatment of advanced cancer. However, ICB cures only a fraction of patients, and biomarkers such as PD-L1 expression or CXCL11 have suboptimal sensitivity and specificity. Exposure-response (E-R) relationships have been observed in other therapeutic mAbs. There are many factors that can influence E-R,1 yet several studies have shown that trough levels of anti-PD-1/PD-L1 correlated with clinical outcomes. Little is known about the potential utility of anti-CTLA-4 levels as a predictive bioma
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O’Toole, Dermot, Alexandru Saveanu, Anne Couvelard, et al. "The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies." European Journal of Endocrinology 155, no. 6 (2006): 849–57. http://dx.doi.org/10.1530/eje.1.02307.

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Objective: Somatostatin (sst) are present in the majority of gastro-entero-pancreatic (GEP) tumours. Effects of somatostatin receptor (sst) analogues are partial and of limited duration. Cell lines derived from GEP express dopaminergic receptors D2. New chimeric analogues simultaneously recognising sst2 and sst5 or sst2 and D2 have additive effects in inhibition of GH and prolactin secretion in pituitary adenomas. Our aim was to quantify the expression of sst and D2 mRNA in human GEP tumours. Design and methods: mRNA expression of sst1, sst2, sst3 and sst5 as well as D2, was analysed using rea
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PALACIOS, ADRIAN G., RANJANA SRIVASTAVA, and TIMOTHY H. GOLDSMITH. "Spectral and polarization sensitivity of photocurrents of amphibian rods in the visible and ultraviolet." Visual Neuroscience 15, no. 2 (1998): 319–31. http://dx.doi.org/10.1017/s0952523898152136.

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Photocurrents from isolated rods of adults and sub-adults of three species of amphibians, Rana pipiens, Ambystoma tigrinum, and Xenopus laevis, were measured with suction pipette electrodes. The intensity for a half-maximal response was 0.91 ± 0.48 photons μm−2 flash−1 (mean ± s.d., 10-ms flashes) for Rana, 0.92 ± 0.44 for Ambystoma, and 6.14 ± 1.33 for Xenopus. The mean number of photoisomerizations at half-saturation was 22 ± 12 for Rana, 50 ± 24 for Ambystoma, and 221 ± 48 for Xenopus. The photocurrent per photoisomerization is several times smaller in Xenopus rods than in the other two spe
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Huang, Ying, Nima S. Hejazi, Bryan Blette, et al. "Stochastic Interventional Vaccine Efficacy and Principal Surrogate Analyses of Antibody Markers as Correlates of Protection against Symptomatic COVID-19 in the COVE mRNA-1273 Trial." Viruses 15, no. 10 (2023): 2029. http://dx.doi.org/10.3390/v15102029.

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The COVE trial randomized participants to receive two doses of mRNA-1273 vaccine or placebo on Days 1 and 29 (D1, D29). Anti-SARS-CoV-2 Spike IgG binding antibodies (bAbs), anti-receptor binding domain IgG bAbs, 50% inhibitory dilution neutralizing antibody (nAb) titers, and 80% inhibitory dilution nAb titers were measured at D29 and D57. We assessed these markers as correlates of protection (CoPs) against COVID-19 using stochastic interventional vaccine efficacy (SVE) analysis and principal surrogate (PS) analysis, frameworks not used in our previous COVE immune correlates analyses. By SVE an
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Jarvis, Nicholas, Amaal J. Starling, and Todd J. Schwedt. "Photophobia symptoms and visual pain thresholds in posttraumatic headache after mild traumatic brain injury." Neurology 91, no. 23 Supplement 1 (2018): S11.2—S11. http://dx.doi.org/10.1212/01.wnl.0000550668.55103.10.

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BackgroundLight sensitivity can be a disabling symptom in posttraumatic headache (PTH). The objective of this pilot study was to characterize photophobia symptoms and visual pain thresholds in PTH compared to healthy controls (HC).MethodsIndividuals with PTH attributed to mild traumatic brain injury (mTBI) (N = 18) and HC (N = 20), aged 18–65, were prospectively assessed using the Photosensitivity Assessment Questionnaire (PAQ), State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). A progressive light stimulation device was used to quantify visual pain thresholds. Visual p
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Al-Gharawi, Firas Abdul Karim Makki, Hamza Nouri Al-Dulaimi, and Naim Shteiwi Matar. "Effect of Adding Different Levels of Potassium on Some Vegetative Growth Characteristics of Maize Under Water Stress Conditions." IOP Conference Series: Earth and Environmental Science 1262, no. 5 (2023): 052054. http://dx.doi.org/10.1088/1755-1315/1262/5/052054.

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Abstract A field experiment was conducted for the autumn season in 2022 in an agricultural land in the province of Raranjia (Hamzawiyah), 10 km south of Babylon Governorate, the center of Hilla, in soil with sandy clay mixed texture to improve the growth efficiency of the Maize plants (Zea mays L.) Fajr 1 cultivar under water stress conditions by the effect of irrigation durations and the addition of different amounts of potassium sulfate. The experiment was designed in randomized complete block design (R.C.B.D) with three replicates. in a split - plots arrangement, as the irrigation periods i
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Sansur, Charles A., Nicholas M. Caffes, David M. Ibrahimi, et al. "Biomechanical fixation properties of cortical versus transpedicular screws in the osteoporotic lumbar spine: an in vitro human cadaveric model." Journal of Neurosurgery: Spine 25, no. 4 (2016): 467–76. http://dx.doi.org/10.3171/2016.2.spine151046.

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OBJECTIVE Optimal strategies for fixation in the osteoporotic lumbar spine remain a clinical issue. Classic transpedicular fixation in the osteoporotic spine is frequently plagued with construct instability, often due to inadequate cortical screw–bone purchase. A cortical bone trajectory maximizes bony purchase and has been reported to provide increased screw pullout strength. The aim of the current investigation was to evaluate the biomechanical efficacy of cortical spinal fixation as a surgical alternative to transpedicular fixation in the osteoporotic lumbar spine under physiological loadin
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Malyugin, B. E., A. M. Gelyastanov, O. P. Antonova, A. V. Belodedova, and A. A. Khaletskaya. "Comparative Analysis of Clinical and Functional Results of Standard and Modified Endothelial and Descemet Membrane Transplantation Techniques." Ophthalmology in Russia 20, no. 1 (2023): 95–104. http://dx.doi.org/10.18008/1816-5095-2023-1-95-104.

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Purpose: to evaluate the clinical and functional results of two methods of Descemet’s membrane endothelial keratoplasty using a full and half graft.Patients and methods. This study is based on surgical treatment of 54 patients (54 eyes) with cataracts and Fuchs endothelial corneal dystrophy were divided into two groups. In the first one, phacoemulsification of cataract with implantation of a hydrophobic IOL and standard «classical» technique of Descemet’s membrane endothelial keratoplasty were performed, it included 30 patients (30 eyes). The second group underwent cataract phacoemulsification
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Moore, Margaret M., David W. Huffman, Peter Z. Fulé, W. Wallace Covington, and Joseph E. Crouse. "Comparison of Historical and Contemporary Forest Structure and Composition on Permanent Plots in Southwestern Ponderosa Pine Forests." Forest Science 50, no. 2 (2004): 162–76. http://dx.doi.org/10.1093/forestscience/50.2.162.

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Abstract We compared historical (1909–1913) and contemporary (1997–1999) forest structure and composition on 15 permanent plots in ponderosa pine (Pinus ponderosa Dougl. ex Laws.) forests of Arizona and New Mexico. We used the same sampling methods as in the early 1900s and compared stand density, diameter distributions, species composition, and broad age classes from the two periods. Stand density (trees ≥9.14 cm dbh) significantly (P < 0.001) increased on plots from an average of 77.4 trees per plot (s = 49.9) at plot establishment in 1909–1913 to 519.1 trees per plot (s = 252.3) at r
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Hernández-Fernández, Francisco, Hernán Sandoval Valencia, Rosa Angélica Barbella-Aponte, et al. "Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description." Brain 143, no. 10 (2020): 3089–103. http://dx.doi.org/10.1093/brain/awaa239.

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Abstract Since the appearance of the first case of coronavirus disease 2019 (COVID-19) a pandemic has emerged affecting millions of individuals worldwide. Although the main clinical manifestations are respiratory, an increase in neurological conditions, specifically acute cerebrovascular disease, has been detected. We present cerebrovascular disease case incidence in hospitalized patients with SARS-CoV-2 infection. Patients were confirmed by microbiological/serological testing, or on chest CT semiology. Available data on co-morbidity, laboratory parameters, treatment administered, neuroimaging
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Aleksova, A., A. Fluca, B. Pani, et al. "POOR GLYCEMIC CONTROL IS ASSOCIATED WITH ELEVATED LEVELS OF CIRCULATING AMYLOID BETA 1–40 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION." European Heart Journal Supplements 26, Supplement_2 (2024): ii21. http://dx.doi.org/10.1093/eurheartjsupp/suae036.043.

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Abstract Background Recent evidence correlates Alzheimer‘s disease (AD) and diabetes mellitus (DM), through the involvement of reduced insulin–like growth factor (IGF–1). In acute myocardial infarction (AMI), low IGF–1 levels are correlated with a high risk of mortality and re–infarction. However, the DM–amyloid 1–40 (Aβ1–40) association in patients with coronary artery disease (CAD) remains unexplored. Aim and Methods To study Aβ1–40 concentrations based on glycaemic status, identify predictors of its levels, and assess the relationship between this peptide and IGF–1, we collected blood sampl
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Rojo-Tolosa, Susana, José Antonio Sánchez-Martínez, Laura Elena Pineda-Lancheros, et al. "Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype." International Journal of Molecular Sciences 24, no. 8 (2023): 7029. http://dx.doi.org/10.3390/ijms24087029.

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Omalizumab is a monoclonal antibody indicated for the treatment of severe uncontrolled asthma with an allergic phenotype. Its effectiveness could be influenced by clinical variables and single nucleotide polymorphisms (SNPs) in one or more of the genes involved in the mechanism of action and process of response to omalizumab, and these could be used as predictive biomarkers of response. We conducted an observational retrospective cohort study that included patients with severe uncontrolled allergic asthma treated with omalizumab in a tertiary hospital. Satisfactory response after 12 months of
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Murakami, Haruka, Ryoko Kawakami, Satoshi Nakae, et al. "Accuracy of 12 Wearable Devices for Estimating Physical Activity Energy Expenditure Using a Metabolic Chamber and the Doubly Labeled Water Method: Validation Study." JMIR mHealth and uHealth 7, no. 8 (2019): e13938. http://dx.doi.org/10.2196/13938.

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Background Self-monitoring using certain types of pedometers and accelerometers has been reported to be effective for promoting and maintaining physical activity (PA). However, the validity of estimating the level of PA or PA energy expenditure (PAEE) for general consumers using wearable devices has not been sufficiently established. Objective We examined the validity of 12 wearable devices for determining PAEE during 1 standardized day in a metabolic chamber and 15 free-living days using the doubly labeled water (DLW) method. Methods A total of 19 healthy adults aged 21 to 50 years (9 men and
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Câmara, Antônio Carlos Lopes, Robério Gomes Olinda, Luciana Dalcin, Ivana Cristina Nunes Gadelha, Jael Soares Batista, and Benito Soto-Blanco. "Accumulative Copper Poisoning in Sheep in Northeastern Brazil." Acta Scientiae Veterinariae 44, no. 1 (2016): 6. http://dx.doi.org/10.22456/1679-9216.84521.

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Background: Despite the proven copper deficiency in several parts of Brazil, reports of acute and accumulative copper poisoning are increasing in ruminants. Sheep are known to be far more sensible to copper toxicity than cattle, but the sensibility of goats is not quite known. The present paper aimed to describe the epidemiological, clinical, laboratorial and pathological findings of two outbreaks of accumulative copper poisoning in sheep fed poultry litter in Ceará and Rio Grande do Norte, Northeastern Brazil, and to compare these findings with national outbreaks.Cases: Two outbreaks of coppe
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Kuei, Nina, Niren Patel, Hongyan Xu, et al. "Characteristics and Potential Biomarkers for Chronic Pain in Patients with Sickle Cell Disease." Blood 126, no. 23 (2015): 986. http://dx.doi.org/10.1182/blood.v126.23.986.986.

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Abstract Vaso-occlusive episodes (VOE) or pain crises are a hallmark of sickle cell disease (SCD), with increasing recognition that a significant portion of SCD patients develop chronic pain. In the landmark PiSCES study (Smith et al), patients reported pain on 55% days, with ~30% reporting pain on >90% days. Thus, the episodic, nociceptive pain (VOE) in younger patients, evolves into a chronic pain syndrome, with neuropathic and centralized components in some adults. Kutlar et al (Blood, 2014), reported on the association of different pain related phenotypes (pain diaries, frequency of hos
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Harfouche, Manale, Sawsan AlMukdad, Asalah Alareeki, et al. "Estimated global and regional incidence and prevalence of herpes simplex virus infections and genital ulcer disease in 2020: mathematical modelling analyses." Sexually Transmitted Infections, December 10, 2024, sextrans—2024–056307. https://doi.org/10.1136/sextrans-2024-056307.

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ObjectivesGenital herpes simplex virus (HSV) type 1 and 2 infections are lifelong and can cause symptomatic genital ulcer disease (GUD). HSV-2 almost always causes sexually transmitted genital infection, while HSV-1 mainly causes oral infection but can be sexually transmitted to cause genital infection. This study estimated genital infection with both HSV types and associated GUD globally in 2020, breaking down the data by WHO region and sex for females and males.MethodsA calibrated mathematical model was employed to generate estimates for the incidence and prevalence of HSV-2 infection, genit
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Bathla, Girish, Sarv Priya, Neetu Soni, and Colin Derdeyn. "Abstract WP72: Low kV Computed Tomography Cerebral Angiogram Using Third-Generation Reconstruction Algorithm Provides Significantly Improved Image Quality With Lower Contrast and Radiation Exposure." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.wp72.

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Introduction/Aim: We aimed to determine if CTA imaging using third generation reconstruction algorithm and lower contrast dose-low kVp technique (LD-CTA) was comparable to regular contrast dose CTA at 120 kVp using a sinogram affirmed iterative reconstruction algorithm (ND-CTA). Methods: Retrospective imaging review of 100 consecutive patients (50 each in LD- and ND-CTA groups). Two readers independently assessed the subjective image quality across multiple vascular segments on a Likert-like scale. Contrast- and signal-to-noise ratios (CNR/ SNR) were compared for the mid-M1-MCA vessels bilater
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Korostyshevskyi, Oleksandr, Cameron Wetzel, Ivan V. Borzenets, David M. Lee, and Vladimir V. Khmelenko. "Luminescence of Nitrogen–Neon Nanoclusters." Journal of Low Temperature Physics, May 23, 2025. https://doi.org/10.1007/s10909-025-03304-4.

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Abstract The decay dynamics of the $$\alpha$$ α -group ( $$^2$$ 2 D $$\rightarrow ^4$$ → 4 S transition) of N atoms stabilized in the collection of $$\hbox {N}_2$$ N 2 –Ne nanoclusters were studied at a temperature of 1.3 K. The variation of the $$\hbox {N}_2$$ N 2 /Ne ratio in nanoclusters results in substantial changes in the luminescence spectra of the $$\alpha$$ α -group and in the characteristic decay times for the components of these spectra. In all obtained $$\alpha$$ α -group spectra, the narrow component at $$\lambda$$ λ = 519.9 nm was observed. The spectroscopic results provide infor
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Yue, Xiaoping, Yitong Li, Lin Yang, Di Sang, Zedu Huang, and Fener Chen. "Sustainable Asymmetric Synthesis of Diltiazem Precursor Enabled by Recombinant Escherichia coli Whole Cells Co‐Expressing an Engineered Ketoreductase and Glucose Dehydrogenase." Biotechnology Journal, December 4, 2023. http://dx.doi.org/10.1002/biot.202300250.

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AbstractAs a key synthetic intermediate of the cardiovascular drug diltiazem, methyl (2R,3S)‐3‐(4‐methoxyphenyl) glycidate ((2R,3S)‐MPGM) (1) is accessible via the ring closure of chlorohydrin (3S)‐methyl 2‐chloro‐3‐hydroxy‐3‐(4‐methoxyphenyl)propanoate ((3S)‐2). We report the efficient reduction of methyl 2‐chloro‐3‐(4‐methoxyphenyl)‐3‐oxo‐propanoate (3) to (3S)‐2 using an engineered enzyme SSCRM2 possessing 4.5‐fold improved specific activity, which was obtained through the structure‐guided site‐saturation mutagenesis of the ketoreductase SSCR by reliving steric hindrance and undesired inter
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Hamilton, Michael A., J. Javier Álvaro, Sandra M. Barr, et al. "U-Pb zircon ages from tuffaceous beds in the Terreneuvian to Cambrian Series 2 sections of Avalonian southern New Brunswick, Canada: New constraints on chronostratigraphic correlations and the Cambrian time scale." Geological Society, London, Special Publications 542, no. 1 (2023). http://dx.doi.org/10.1144/sp542-2022-11.

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Abstract Avalonian sections in the Saint John area, southern New Brunswick, have long contributed to global understanding of Cambrian chronostratigraphy. A tuffaceous bed in the Ratcliffe Brook Formation (RBF) in the Somerset Street section dated at ca. 531 Ma has traditionally been considered to postdate small shelly fossils attributed to the Watsonella crosbyi Zone in the Hanford Brook section. A fine-grained tuffaceous bed approximately 10 m stratigraphically lower in the Somerset Street section yields a CA-IDTIMS zircon age of 532.3 ± 0.3 Ma; a tuffaceous carbonate unit in the lower RBF in
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Rasonabe, Zinna Marie P., Charlene G. Tiausas, Jannelle D. Cruz, and Francheska Areza. "Chemical Composition, Anti-Inflammatory and Analgesic Activities of Extracts and Fractions of Vitex negundo." Journal of Pharmaceutical Research International, December 20, 2022, 1–14. http://dx.doi.org/10.9734/jpri/2022/v34i587259.

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This study aims to determine chemical components and demonstrate the anti-inflammatory and analgesic activities of Vitex negundo species native to the Philippines. Using high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), eleven compounds were tentatively identified from the iridoids, flavonoids, and phenolics group. The anti-inflammatory activity was determined by measuring the inhibition of proinflammatory enzymes, lipoxygenase (LOX), and cyclooxygenase (COX-2). For LOX inhibitory effect, crude methanol extract has an IC50 value of 440
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Ogunfolaji, Oloruntoba, Adrien Tangmi, Olaoluwa Ezekiel Dada, et al. "Profiling African Health Journals: A Bibliometric Study." International Journal of Public Health 67 (November 10, 2022). http://dx.doi.org/10.3389/ijph.2022.1604932.

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Objectives: This study aimed to map out African health journals using publicly-available information on major databases.Methods: The authors searched the African Journals Online Library (AJOL) and Scientific Journal Rankings (SJR) databases from their inception in 1998 and 1996 respectively to 17 October 2020, and identified African health journals. The authors extracted data on journal scope, PubMed indexation, open-access status, publishing fees, Journal Publishing Practices and Standards rating and bibliometrics. The data were compared with health journals from other regions using the Chi-s
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