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Journal articles on the topic '519.6: 519.23: 616.12'

Author: Grafiati
Published: 30 May 2022
Last updated: 31 July 2025

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1

Manyore, Melvin Salvatore. "INFLUENCE OF FOOD AVAILABILITY ON THE NUTRITIONAL STATUS OF CHILDREN OF 6 MONTHS TO 23 MONTHS." International Journal of Health Sciences 3, no. 1 (2021): 13–17. http://dx.doi.org/10.47941/ijhs.519.

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Purpose: The study, therefore, seeks to establish the relationship between the food availability and nutritional status of children of 6 months to 23 months. Specifically, the study will seek to determine the influence of food availability, food accessibility, food utilization and food safety on the nutritional status of children of 6 months to 23 months in Kenya.Methodology: The study will take a case study of Kenyan referral level 5 hospital. The hospital has approximately 600 mothers to children of 6 months to 23 months attending clinic in a month. This study will adopt descriptive cross se
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Favara, David M., Lavinia Spain, Lewis Au, et al. "Five-year review of corticosteroid duration and complications in the management of immune checkpoint inhibitor-related diarrhoea and colitis in advanced melanoma." ESMO Open 5, no. 4 (2020): e000585. http://dx.doi.org/10.1136/esmoopen-2019-000585.

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BackgroundImmune-related diarrhoea/colitis (ir-D/C) is a common adverse event of immune checkpoint inhibitor (ICI) therapy. Guidelines recommend corticosteroid (CS) treatment; however, the average treatment duration for ir-D/C remains poorly defined.MethodsAll advanced melanoma patients treated with ICI therapy at the Royal Marsden Hospital between 2011 and 2016 were reviewed to identify ir-D/C cases alongside clinical variables.Results117 any-grade ir-D/C episodes occurred in 109 (21%) patients out of a total of 519 patients treated (ipilimumab=77 episodes, anti-PD1=17 (nivolumab or pembroliz
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3

Särkijärvi, Susanna, Riitta Sormunen-Cristian, Terttu Heikkilä, et al. "Hevosten Nurmirehut –hanke. Nurmikasvilajin ja korjuuajan vaikutus sulavuuteen hevosilla." Suomen Maataloustieteellisen Seuran Tiedote, no. 23 (January 31, 2008): 1–4. http://dx.doi.org/10.33354/smst.76932.

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Tutkimuksessa käytettiin viikon välein korjattuja säilörehuja, joiden sulavuus määritettiin sonnankokonaiskeruumenetelmällä hevosilla ja pässeillä. Hevosilla sulavuus määritettiin myös merkkiaineilla,joita olivat sulamaton kuitu (iNDF) ja kromioksidi (Cr2O3). Lisäksi rehujen orgaanisen aineen sulavuusmääritettiin in vitro -sellulaasimenetelmällä laboratoriossa. Tarkoituksena oli verrata eri menetelmiensopivuutta hevosten nurmirehujen sulavuuden määritykseen sekä selvittää, millä tarkkuudella hevosilletarkoitettujen rehujen sulavuus voidaan määrittää pässeillä. Kasvilajivertailussa olevista reh
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Calais, Jeremie, Wolfgang P. Fendler, Matthias Eiber, et al. "RESIST-PC phase 2 trial: 177Lu-PSMA-617 radionuclide therapy for metastatic castrate-resistant prostate cancer." Journal of Clinical Oncology 37, no. 15_suppl (2019): 5028. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.5028.

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5028 Background: This is an investigator-initiated open-label prospective bi-centric single-arm phase 2 clinical trial (NCT03042312) of 177Lu-PSMA-617 radionuclide therapy in patients with progressive metastatic castrate-resistant prostate cancer (mCRPC). Methods: Patients with progressive mCRPC (biochemical, radiographic or clinical) after ≥1 novel androgen axis drug (NAAD), either chemotherapy (CTX) naïve or post-CTX, with sufficient bone marrow reserve and normal kidney function were eligible. All patients underwent a screening PSMA PET/CT to confirm target expression. Patients received up
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Mellor, Adrian, Christopher Boos, Mike Stacey, et al. "Neutrophil Gelatinase-Associated Lipocalin: Its Response to Hypoxia and Association with Acute Mountain Sickness." Disease Markers 35 (2013): 537–42. http://dx.doi.org/10.1155/2013/601214.

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Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n=22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n=14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n=52) to over 5000 m. NGAL did no
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An, Y. K., N. Lindsay, N. Allan, et al. "P663 Post-ustekinumab induction IL12, IL23, and ustekinumab levels are associated with clinical response in a multi-centre prospective cohort study of Crohn’s disease patients: results from the AURORA Study including ANZIBDC Cohort." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i793—i794. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0793.

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Abstract Background Ustekinumab (UST) is a monoclonal antibody targeting IL-12 and IL-23 through their shared p40 subunit. This study aimed to determine the clinical outcomes after UST treatment in Crohn’s disease (CD) patients in a real-world setting, and to investigate the association of clinical outcomes with IL-12, IL-23 and UST levels. Methods A multi-centre prospective observational cohort study of UST for moderate to severe CD was conducted. Patients were recruited from 19 Australian centres between Sep 2019 and Apr 2022. Clinical assessments were performed at baseline study visit (SV)
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Vuckovic, C., A. Cremer, C. Minsart, J. Bottieau, D. Franchimont, and C. Liefferinckx. "P0488 The course of Crohn’s Disease in the Biologics Era: an in depth Single-Center Tertiary Cohort Study in Belgium." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i1023—i1024. https://doi.org/10.1093/ecco-jcc/jjae190.0662.

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Abstract Background Since 1999, Biologics have become a cornerstone in the management of Crohn’s Disease (CD), enabling complete mucosal healing in a significant proportion of patients, with measurable changes in major outcomes in large phase III/IV clinical trials. This holds true particularly when patients were exposed early at diagnosis to biologics, as reported in the recent PROFILE study. However, their real-world impact on the long-term course of the disease remains uncertain. This retrospective study aims to characterize the natural history of CD before and during the biologic era, in a
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Garip, Sevinç, Sibel Çetinalp, and Elife Aşut. "THE ROLE OF COLONOSCOPY IN PEDIATRIC DIAGNOSIS AND TREATMENT: A 6-YEAR SINGLE-CENTER EXPERIENCE." Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 26, no. 3 (2024): 276–83. https://doi.org/10.24938/kutfd.1460671.

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Objective: In pediatrics, colonoscopy is routinely used safely and effectively for the diagnosis and treatment of gastrointestinal system diseases. The most common colonoscopy indications in childhood are; lower gastrointestinal bleeding, chronic diarrhea and chronic abdominal pain. We aimed to contribute to the literature by retrospectively examining the characteristics of pediatric patients who underwent colonoscopy in our clinic. Material and Methods: Pediatric patients who underwent colonoscopy by a single pediatric gastroenterologist during the 6-year period between August 2017 and August
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9

Heald, A., S. Anderson, A. Khan, et al. "Success Rates in a Diabetes Specialist Nurse-Led Education Programme: Re-setting the Glucostat." Experimental and Clinical Endocrinology & Diabetes 125, no. 05 (2016): 297–300. http://dx.doi.org/10.1055/s-0042-108055.

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Abstract Analysis of National Diabetes Audit data from 2011–2012 of newly diagnosed people with type 1 diabetes mellitus (DM) found low initial success rates in much of the UK at 20% on initial training, while an unusually high success rate of 75% achieving target HbA1C<58 mmol/mol (< 7.5%) was found in Cheshire (England average=40.8%). We present a review of the approach taken by the Cheshire Diabetes team in the 12 months following diagnosis. Between 2012 and 2013, 15 consecutive newly diagnosed people with type 1 DM were followed up for 18 months. All received support and advice by co
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Gagnon, Daniel, and Glen P. Kenny. "Exercise-rest cycles do not alter local and whole body heat loss responses." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 4 (2011): R958—R968. http://dx.doi.org/10.1152/ajpregu.00642.2010.

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Previous studies have suggested that greater core temperatures during intermittent exercise (Ex) are due to attenuated sweating [upper back sweat rate (SR)] and skin blood flow (SkBF) responses. We evaluated the hypothesis that heat loss is not altered during exercise-rest cycles (ER). Ten male participants randomly performed four 120-min trials: 1) 60-min Ex and 60-min recovery (60ER); 2) 3 × 20-min Ex separated by 20-min recoveries (20ER); 3) 6 × 10-min Ex separated by 10-min recoveries (10ER), or 4) 12 × 5-min Ex separated by 5-min recoveries (5ER). Exercise was performed at a workload of 1
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Lupu, Olguța. "Accessibility and Avantgarde in Tiberiu Olah’s Music for Osânda." Musicology Today: Journal of the National University of Music Bucharest, no. 60 (June 4, 2025): 307–26. https://doi.org/10.69608/mt.60.03.

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1. Buzoianu, Dumitru 1971 “Tiberiu Olah: ‘Arta nu se face după rețete’” [Tiberiu Olah: Art is Not Made by Following Recipes], România Literară [Literary Romania], 4/21, May 20, 27. 2. Caranfil, Tudor 2008 Dicționar universal de filme [Universal Film Dictionary] (Bucharest: Litera Internațional). 3. Căliman, Călin 2000 Istoria filmului românesc (1897-2000) [The History of Romanian Film (1897-2000)] (Bucharest: Editura Fundației Culturale Române). 4. Ioan, Mariana 1982a “Ce vă spune muzica de film? Cornelia Tăutu: Fiecare film, o explorare artistică” [What Does Film Music Tell You? Cornelia Tăutu: Ev
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Costa, Luciano J., Geoffrey L. Uy, Parameswaran N. Hari, et al. "Contribution of Chemotherapy Mobilization to Disease Control in Multiple Myeloma Treated with Autologous Transplantation." Blood 124, no. 21 (2014): 2447. http://dx.doi.org/10.1182/blood.v124.21.2447.2447.

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Abstract Background: Autologous hematopoietic progenitor cells (auto-HC) can be mobilized either by hematopoietic growth factors (GF) alone or cytotoxic chemotherapy + GF (CC+GF). The latter is associated with higher CD34+ yields, but is associated with increased costs and risks of infection and hospitalization. In patients with multiple myeloma (MM) undergoing Auto-HCT, it is uncertain whether mobilization with CC+GF affects post transplant outcomes. Methods: We conducted a retrospective analysis of patients with MM undergoing their first AHPCT following high dose melphalan (≥140 mg/m2) betwe
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Neuzillet, Cindy, Corinne Emery, Clément Teissier, Stéphane Bouée, and Astrid Lièvre. "Epidemiology and patterns of care of intrahepatic cholangiocarcinoma (iCCA) in France: Real-life data from the French National Hospital‐Discharge Summaries Database System (PMSI)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16624-e16624. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16624.

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e16624 Background: Little is known about epidemiology and patterns of care of iCCA in daily clinical practice. The aims of this study were to estimate from real-life data the incidence of iCCA in France and to describe the healthcare pathways of these patients (pts). Methods: A retrospective analysis was carried out using the nationwide prospective French PMSI database. All pts with a new diagnosis of "carcinoma of the intrahepatic bile duct" who had a 1st hospital stay in Medicine, Surgery and Obstetrics departments (MSO) between 2014 and 2015 with a 2-year follow-up were included. Data relat
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Gangadhar, Tara C., Bryan J. Schneider, Todd Michael Bauer, et al. "Efficacy and safety of epacadostat plus pembrolizumab treatment of NSCLC: Preliminary phase I/II results of ECHO-202/KEYNOTE-037." Journal of Clinical Oncology 35, no. 15_suppl (2017): 9014. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.9014.

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9014 Background: ECHO-202/KEYNOTE-037 is an open-label, phase 1/2 study of epacadostat (a potent and selective oral inhibitor of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1) plus pembrolizumab (E + P) in patients (pts) with advanced tumors. We report preliminary efficacy and safety outcomes for the phase 1/2 NSCLC cohort. Methods: Adult pts with prior platinum-based therapy (tx) and no prior checkpoint inhibitor tx were eligible. Phase 1 dose-escalation tx was E (25, 50, 100, 300 mg PO BID) + P (2 mg/kg or 200 mg IV Q3W); MTD was not exceeded. E (100 mg BID) + P (200 mg Q3W) tx
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Rosen, Ezra, Timothy A. Yap, Elisa Fontana, et al. "Abstract B045: Ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in combination with low dose gemcitabine in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B045. http://dx.doi.org/10.1158/1535-7163.targ-23-b045.

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Abstract Background: Antitumor activity and good tolerability of camonsertib (cam) monotherapy in patients (pts) with recurrent solid tumors was previously reported. Preclinical data showed that cam-related tumor cell death is potentiated by the replication stress-inducing agent gemcitabine (gem) even at low doses, resulting in synergistic combination activity. We evaluated safety/tolerability and efficacy of cam+gem in this Ph1b trial (TRESR; NCT04497116). Methods: A tumor xenograft (Granta-519; ATM loss of function) was tested with a range of cam+gem doses. Pts >18yr, ECOG 0-1, with a
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Ni, Xiaofei, Rongli Zhang, and Erlie Jiang. "Selinexor Combined with Reduce Intensity Conditioning of BU/CY for Allogeneic HSCT in Elderly Patients with Relapsed/Refractory AML/MDS." Blood 144, Supplement 1 (2024): 7310. https://doi.org/10.1182/blood-2024-203374.

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Objective: To investigate the safety and efficacy of a modified busulfan (Bu)/cyclophosphamide (Cy) conditioning regimen incorporating Selinexor for allogeneic hematopoietic stem cell transplantation in elderly patients with relapsed/refractory hematologic malignancies. Methods: We retrospectively evaluated the clinical outcomes of patients aged 50 and above with hematologic malignancies who had received allo-HSCT with conditioning incorporating Selinexor at the Institute of Hematology and Blood Disease Hospital. Results: Between September 2022 and March 2024, 25 elderly patients with high-ris
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Skou, Søren Thorgaard, Ewa Roos, Mogens Laursen, et al. "Cost-effectiveness of total knee replacement in addition to non-surgical treatment: a 2-year outcome from a randomised trial in secondary care in Denmark." BMJ Open 10, no. 1 (2020): e033495. http://dx.doi.org/10.1136/bmjopen-2019-033495.

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ObjectiveTo assess the 24-month cost-effectiveness of total knee replacement (TKR) plus non-surgical treatment compared with non-surgical treatment with the option of later TKR if needed.Methods100 adults with moderate-to-severe knee osteoarthritis found eligible for TKR by an orthopaedic surgeon in secondary care were randomised to TKR plus 12 weeks of supervised non-surgical treatment (exercise, education, diet, insoles and pain medication) or to supervised non-surgical treatment alone. Including quality-adjusted life years (QALYs) data from baseline, 3, 6, 12 and 24 months, effectiveness wa
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Abdulaziz, S., H. Halabi, S. Bahlas, et al. "AB0366 DIFFUSE ALVEOLAR HEMORRHAGE IN LUPUS NEPHRITIS PATIENTS: MULTICENTER RECTROSPECTIVE STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1483.1–1484. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2953.

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Background:Diffuse alveolar hemorrhage (DAH) is a rare and potentially lethal complication of systemic lupus erythematosus (SLE) with a high mortality rate. It occurs more frequently in patients with lupus nephritis (LN).Objectives:The aim of our study is to explore the characteristics of patients that develop DAH with lupus nephritis, risk factors that predispose DAH, treatment response and outcomes.Methods:Multicenter retrospective cohort study was undertaken including 6 centers in Saudi Arabia from 2002 to 2018. Systemic lupus erythematosus patients meeting the SLICC criteria with lupus nep
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Farmer, Kristine, Jeff Allen, Malak Khader, Tara Zimmerman, and Peter Johnstone. "Paralegal Students’ and Paralegal Instructors’ Perceptions of Synchronous and Asynchronous Online Paralegal Course Effectiveness: A Comparative Study." International Journal for Educational and Vocational Studies 3, no. 1 (2021): 1. http://dx.doi.org/10.29103/ijevs.v3i1.3550.

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To improve online learning pedagogy within the field of paralegal education, this study investigated how paralegal students and paralegal instructors perceived the effectiveness of synchronous and asynchronous online paralegal courses. This study intended to inform paralegal instructors and course developers how to better design, deliver, and evaluate effective online course instruction in the field of paralegal studies.Survey results were analyzed using independent samples t-test and correlational analysis, and indicated that overall, paralegal students and paralegal instructors positively pe
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Veronikis, Irini E., Sharon Alex, Shih-Lieh Fang, et al. "Serum iodothyronine concentrations in intestinally decontaminated rats treated with a 5′-deiodinase type I inhibitor 6-anilino-2-thiouracil." European Journal of Endocrinology 134, no. 4 (1996): 519–23. http://dx.doi.org/10.1530/eje.0.1340519.

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Veronikis IE, Alex S, Fang S-L, Wright G, Wu S-Y, Chanoine JP, Emerson CH, Braverman LE. Serum iodothyronine concentrations in intestinally decontaminated rats treated with a 5′-deiodinase type I inhibitor 6-anilino-2-thiouracil. Eur J Endocrinol 1996;134:519–23. ISSN 0804–4643 Enteric bacteria have been postulated to have a role in thyroid economy by promoting the hydrolysis of thyroid hormone conjugates of biliary origin, thus permitting the absorption and recycling of thyroxine (T4) and triiodothyronine (T3). An enterohepatic circulation of T3 might be more pronounced under conditions in wh
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Leclair, V., A. S. Galindo-Feria, S. Rothwell, et al. "OP0160 HLA-DRB1 ASSOCIATIONS WITH AUTOANTIBODY-DEFINED SUBGROUPS IN IDIOPATHIC INFLAMMATORY MYOPATHIES (IIM)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 104.1–105. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1695.

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BackgroundThere is a gap between how IIM patients are classified in practice and current validated classification criteria1. Also, different associations with genetic variations in HLA can inform about different T-cell mechanisms involved in disease pathogenesis.ObjectivesWe aimed to systematically study associations between HLA-DRB1 alleles, clinical manifestations, and autoantibody-defined IIM subgroups.MethodsWe included 1348 IIM patients from five European countries. An unsupervised cluster analysis was performed using 14 autoantibodies: anti-Jo1, -PL7, -PL12, -EJ, -OJ, -SRP, -U1RNP, -Ro52
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22

Garibaldi, A., G. Gilardi, G. Ortu, and M. L. Gullino. "First Report of Plectosphaerella cucumerina on Greenhouse Cultured Wild Rocket (Diplotaxis tenuifolia) in Italy." Plant Disease 96, no. 12 (2012): 1825. http://dx.doi.org/10.1094/pdis-06-12-0583-pdn.

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During spring 2012, symptoms of an unusual leaf spot disease were observed in several commercial greenhouses near Salerno (southern Italy) on plants of Diplotaxis tenuifolia (cv Selvatica). The first symptoms on leaves of affected plants consisted of small (1 mm) black-brown spots of irregular shape, later coalescing into larger spots, 1 cm in diameter. Spots were surrounded by a yellow halo, and were mostly located on the foliar limb, rib, and petiole. Affected leaves were often distorted, appearing hook-like. The disease was severe under 75 to 90% RH, at air temperature of 20 to 26°C, and ca
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23

Abdul Razzaq, Bashar A., and Tuka Y. Hassan. "Scabies outbreaks during 2019 in Al- Daseem, Al-Rusafa-Baghdad: A retrospective study." Journal of the Faculty of Medicine Baghdad 63, no. 2 (2021): 65–69. http://dx.doi.org/10.32007/jfacmedbagdad.6321833.

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Abstract
 Background: Scabies is a skin infestation by the Sarcoptes scabiei mite. Scabies is transmitted through close personal contact. Settings like hospitals, prisons and childcare centers are at greater risk of outbreaks. Both male and female may be infected with scabies in any age groups. It is common in tropical climate countries poor people who live in rural areas and among displaced patients. It rises significantly among low economic status because skin diseases are significantly associated with a higher crowding index.
 Objectives: To estimate the prevalence of scabies in A
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Chung, Heekyung, Emily Creger, Lauren Sitts, et al. "SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models." Blood 134, Supplement_1 (2019): 4059. http://dx.doi.org/10.1182/blood-2019-124812.

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Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) that accounts for ~7% of all NHL in the U.S. MCL is associated with aberrant activation of the Wnt signaling pathway, which plays a key role in the survival and maintenance of MCL-initiating cells. Many MCL patients experience relapse and subsequent disease progression due to chemoresistance following initial therapy; hence, novel therapies are needed. CLKs regulate the activity of serine/arginine-rich splicing factors (SRSFs) that modulate spliceosome assembly, mRNA splicing, and gene expression. SM09419 is a novel, oral, small
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Domínguez-Casas, L. C., P. Rodriguez Cundin, T. Dierssen-Sotos, et al. "AB0279 HERPES ZOSTER IN RHEUMATOID ARTHRITIS. PROSPECTIVE SINGLE UNIVERSITY CENTER STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1265.2–1266. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3057.

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BackgroundPatients with Rheumatoid arthritis (RA) have an increased risk of infections due to the disease itself, and/or immunosuppressive therapy. The risk of herpes zoster (HZ) including disseminated HZ is also increased(1)ObjectivesIn an unselected series of RA patientswe assessa)prevalence, b)general features and c) predictive factors of HZ.MethodsStudy of 393 RA patients included in the prospective vaccination program of the Preventive Medicine and Rheumatology department of a University hospital, from October 2011 to October 2016. The minimum follow-up was of 12 months; therefore, it was
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Zabotti, A., M. M. Luchetti, C. Selmi, et al. "POS1061 THE ITALIAN PROSPECTIVE SIRENA STUDY: FOCUS ON EARLY PSORIATIC ARTHRITIS COHORT AND GENDER DIFFERENCES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 809. http://dx.doi.org/10.1136/annrheumdis-2021-eular.607.

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Background:Limited data on early Psoriatic Arthritis (PsA) are available1,2.Objectives:To describe baseline data of PsA patients naive to any DMARDs.Methods:SIRENA study is an Italian, prospective Registry of Spondyloarthritis patients diagnosed according to ASAS criteria and naïve to any DMARDs. Data on demographic and clinical characteristics of PsA cohort were collected and analysed, also by gender.Results:203/350 (58%) subjects included in SIRENA Registry had PsA (mean age 51.9 years) and in 190/203 (94%) CASPAR classification criteria were fulfilled. In 70% of patients the diagnosis was p
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Samburskaya, O. V., S. Yu Kalinchenko, and L. O. Vorslov. "Evaluation of the clinical efficacy of the drug NFO lipid balance in the treatment of dyslipidemia." Voprosy dietologii 14, no. 1 (2024): 18–24. http://dx.doi.org/10.20953/2224-5448-2024-1-18-24.

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Objective. To evaluate the possibility of treating dyslipidemia with a medication containing red fermented rice, vitamins B3, B12, B6, B9, and coenzyme Q10. Patients and methods. The study included 24 male and female patients with dyslipidemia, the laboratory-confirmed changes in the lipid profile, which was assessed by the levels of total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triglycerides in blood tests. The treatment did not include dietary correction. All patients received a medication containing red fermented rice, vitamins B3, B12, B6, B9, and
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LaGoy, Alice, Joseph Cuellar, Max Smith, et al. "0333 Sleep Patterns Throughout Mountain Warfare Training in U.S. Marines Measured Using a Consumer Wearable." SLEEP 47, Supplement_1 (2024): A143. http://dx.doi.org/10.1093/sleep/zsae067.0333.

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Abstract Introduction Poor acclimatization, high training demands, and sleeping conditions in the field can compromise the sleep of military personnel completing mountain warfare training. As chronic poor sleep can impact performance and recovery, individual differences in sleep may relate to differences in resilience during prolonged training. We characterized sleep patterns of Marines completing a mountain warfare training exercise (MTX) using a consumer wearable and explored relationships between sleep patterns and stress during training. Methods Marines (n = 59, aged 22±4 years [mean ± SD]
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Li, Xiao-yang, Yan Li, Bing Yan, and Dong Qian. "Hypofraction radiotherapy followed by immune checkpoint inhibitors for locally advanced non-small cell lung cancer: A phase I/II trial." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8058. https://doi.org/10.1200/jco.2025.43.16_suppl.8058.

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8058 Background: To explore the safety and primary efficacy of hypofraction radiotherapy followed by immune checkpoint inhibitors (ICI) for stage III locally advanced non-small cell lung cancer patients. Methods: Patients with stage III non-small cell lung cancer were enrolled to receive hypofraction radiotherapy (48-64Gy/12-16f) followed by ICI maintenance treatment. After the completion of radiotherapy, one-year maintenance ICI treatment was encouraged. The primary objective was to explore the toxicity of hypofractionated radiotherapy with immunotherapy. The secondary objective was survival
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Guilhot, Francois, Hagop Kantarjian, Neil P. Shah, et al. "Dasatinib (Versus Imatinib) In Patients (Pts) with Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP): Analysis of Safety and Efficacy by Use of Baseline Medications In the DASISION Trial." Blood 116, no. 21 (2010): 2295. http://dx.doi.org/10.1182/blood.v116.21.2295.2295.

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Abstract Abstract 2295 Background: During first-line BCR-ABL inhibitor therapy for CML-CP, concomitant medication use is associated with worse adherence to CML therapy, which may detrimentally affect efficacy (St Charles, ASH 2009; Marin, J Clin Oncol 2010). Medications may include adjuvants to anti-CML therapy or treatments for comorbid conditions. Depending on posology, the number of medications may affect BCR-ABL inhibitor efficacy and safety. Dasatinib is a BCR-ABL inhibitor 325-fold more potent than imatinib at inhibiting BCR-ABL in vitro and is taken once daily (QD) at any time of day wi
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Craddock, Charles, Myriam Labopin, Gerard Socie, et al. "Contrasting Factors Determine the Kinetics of Disease Relapse after Allogeneic Stem Cell Transplantation (allo-SCT) for Acute Myeloid Leukaemia (AML): a Survey from the Acute Leukaemia Working Party of the EBMT." Blood 124, no. 21 (2014): 3945. http://dx.doi.org/10.1182/blood.v124.21.3945.3945.

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Abstract Disease relapse remains the major cause of treatment failure in patients allografted for AML. Post transplant interventions, such as donor lymphocyte infusion or adjunctive targeted therapies, represent novel strategies with the potential to reduce the risk of disease recurrence. Such approaches are however critically dependent on timely intervention prior to disease relapse. Whilst the factors predicting the overall risk of relapse have been well characterized determinants of the kinetics of disease relapse have not been extensively studied. We therefore performed a systematic analys
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Andreoli, L., M. C. Gerardi, F. Crisafulli, et al. "OP0125 THE MANAGEMENT OF PREGNANCY IN AUTOIMMUNE RHEUMATIC DISEASES: ANALYSIS OF 758 PREGNANCIES FROM THE PROSPECTIVE NATIONWIDE P-RHEUM.IT STUDY (THE ITALIAN REGISTRY OF PREGNANCY IN THE RHEUMATIC DISEASES)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 81.1–81. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1431.

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BackgroundPregnancy is a topic of fundamental importance for women living with autoimmune rheumatic diseases (ARD). Efforts at national and international levels have been put in the collection and harmonization of data in order to implement an evidence-based management of pregnant patients.ObjectivesThe P-RHEUM.it study was designed as a nationwide, web-based longitudinal observational cohort study to collect data about pregnancy in ARD in 26 centers in Italy. The study started in May 2018 and has been supported by the Italian Society for Rheumatology.MethodsPregnant patients with a definite r
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Vandecasteele, E., K. Melsens, D. Blockmans, et al. "THU0367 INCIDENCE AND PREVALENCE OF SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE IN FLANDERS: A 12-YEARS COLLABORATIVE MULTICENTER PROSPECTIVE COHORT STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 415.1–416. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1182.

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Background:Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the main cause of death in SSc and accounts for up to 30-35% of SSc-mortality (1-2). All SSc cases, irrespective of the extent of the skin disease, should be evaluated for ILD (3). The epidemiology of SSc-ILD in Belgium is unknown. In literature, the prevalence of ILD in SSc varies between 19% and 52%. However, different criteria were used to diagnose ILD (4). In 2008, Goh et al. proposed a flow diagram to diagnose SSc-ILD based on chest high-resolution CT-scan (HRCT) and pulmonary function tests (PFTs). Their cate
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Yee, Marianne E., Peter A. Lane, James R. Eckman, and Antonio Guasch. "Angiotensin Blockage with Losartan Is Associated with Decreased Albuminuria and Stable Renal Function in Adults and Children with HbSS on Hydroxyurea." Blood 126, no. 23 (2015): 2183. http://dx.doi.org/10.1182/blood.v126.23.2183.2183.

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Abstract Introduction: Sickle cell nephropathy (SCN) is a progressive complication of sickle cell disease (SCD) that begins in childhood and may result in renal failure and early mortality; yet the potential for prevention and reversal of SCN is not known. Urinary albumin/creatinine ratio (ACR) is a biomarker of glomerular damage but may not correlate with renal hemodynamic abnormalities that are indicative of early renal failure, e.g. glomerular filtration rate (GFR), renal plasma flow (RPF), and glomerular membrane permeability. We hypothesized that the angiotensin receptor blocker losartan
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Smolen, J. S., T. Korotaeva, M. Nurmohamed, et al. "AB0530 EFFECT OF SKIN SYMPTOMS ON DISEASE IMPACT IN PATIENTS WITH PSORIATIC ARTHRITIS RECEIVING THE IL-12/23 INHIBITOR USTEKINUMAB OR TNF INHIBITORS IN THE REAL-WORLD PSABIO STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1295–96. http://dx.doi.org/10.1136/annrheumdis-2021-eular.767.

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Background:Psoriatic arthritis (PsA) is characterised by musculoskeletal symptoms, and patients (pts) with PsA usually experience psoriasis concurrently. Real-world data reflecting impact of skin symptoms on PsA disease burden are limited.Objectives:Analyse effectiveness of ustekinumab (UST) and tumour necrosis factor inhibitor (TNFi) therapy on extent of skin involvement, and the impact this has on PsA disease burden and drug persistence.Methods:PsABio (NCT02627768) is a prospective, observational study of 1st/2nd/3rd-line UST or TNFi treatment in PsA in 8 European countries. Extent of skin i
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Koca, S. S., Y. Pehlivan, S. Akar, et al. "AB0561 DISEASE DURATION AND HLA-B27 POSITIVITY ALTER LONGTERM RETENTION RATE OF CERTOLIZUMAB PEGOL IN PATIENTS WITH PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1317.1–1317. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2832.

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Background:Several factors such as effectiveness, safety and compliance affect the drug survival in chronic disorders. Physicians take care of long-term retention rate and responses for discontinuation of candidate drug. Identification of predictors of clinical response to certolizumab-pegol (CZP) may aid the decision-making process for treating patients psoriatic arthritis (PsA).Objectives:The purpose of this study to assess the drug survival of certolizumab pegol (CZP) in patients with PsA and to identify the predictors and reasons for discontinuation.Methods:Data on patient characteristics,
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Phillips, Gordon L., Camille N. Abboud, Steven H. Bernstein, et al. "Phase I Study for Poor Prognosis Lymphoma: Modification of the “BEAM” (BCNU +Etoposide+ARA-C+Melphalan) Regimen with Escalating-Dose Melphalan (MEL) Using Amifostine (AF) Cytoprotection and Autologous Hematopoietic Stem Cell Transplantation (AHSCT)." Blood 108, no. 11 (2006): 3076. http://dx.doi.org/10.1182/blood.v108.11.3076.3076.

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Abstract Background: AHSCT is standard therapy for recurrent or progressive, yet chemosensitive lymphoma, both non-Hodgkin’s (NHL) and Hodgkin’s (HL). However, relapse is frequent, and augmentation of existing conditioning regimens (e.g. BEAM) is one approach to reducing these relapses. Since BEAM has considerable regimen related toxicity (RRT), methods to allow safe dose augmentation are needed. Prior experience (BBMT2004;10(7): 473–83) indicates that AF may be useful in protecting vs RRT produced by high-dose MEL used alone; thus, we postulated a cytoprotective effect in this situation as we
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Porkka, Kimmo, Michele Baccarani, Andreas Hochhaus, et al. "Occurrence, Management, and Outcomes In Patients with Pleural Effusion During Dasatinib Treatment for Chronic-Phase Chronic Myeloid Leukemia (CML-CP) In the First-Line Setting: Analysis of the DASISION Trial." Blood 116, no. 21 (2010): 2282. http://dx.doi.org/10.1182/blood.v116.21.2282.2282.

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Abstract Abstract 2282 Background: The Phase 3 DASISION trial comparing dasatinib 100 mg once daily with imatinib 400 mg once daily as initial treatment in patients (pts) with newly diagnosed CML-CP has demonstrated superior efficacy and favorable safety of dasatinib after a minimum of 12 months of follow-up (Kantarjian, H, et al. N Engl J Med 2010;362:2260). While fluid retention was more frequent with imatinib than with dasatinib, pleural effusion was seen only with dasatinib. Here, we provide a detailed analysis of pts experiencing pleural effusion, a clinically relevant adverse drug reacti
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Bigot, Ludovic, Nobre Nobre, Alice Da silva, et al. "Abstract 1276: UNLOCK, a preclinical platform of PDX models resistant to innovative therapies." Cancer Research 85, no. 8_Supplement_1 (2025): 1276. https://doi.org/10.1158/1538-7445.am2025-1276.

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Abstract Introduction: Over the past 20 years, advances in precision oncology and cancer genetics have identified numerous actionable oncogenic drivers, leading to new drug development and clinical application. However, tumor cells can adapt and develop resistance mechanisms (MoR), and the mechanisms of action (MoA) of these drugs are only partially understood, highlighting the need for research focused on both MoR and MoA. Following the success of the MATCH-R clinical trial (NCT02517892, 2015-2022), the UNLOCK program was launched in 2022 to better understand the MoA and MoR of innovative dru
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Picozzi, Vincent J., Anna M. Varghese, Paul Eliezer Oberstein, et al. "Pamrevlumab plus nab-paclitaxel/gemcitabine (Pam + GA) as first- and second-line therapy in metastatic pancreatic cancer (mPDAC): Results from Precision Promise (PrP) Bayesian platform trial." Journal of Clinical Oncology 43, no. 4_suppl (2025): 673. https://doi.org/10.1200/jco.2025.43.4_suppl.673.

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673 Background: Pamrevlumab (Pam) is a fully human recombinant monoclonal antibody against connective tissue growth factor. Early clinical data with Pam plus chemotherapy showed a favorable safety profile and potential efficacy in PDAC. In PrP, Pam + GA was tested as first line (Line 1) and second line (Line 2) therapy for mPDAC vs GA. PrP is a phase 2/3, innovative Bayesian adaptive platform trial sponsored by the Pancreatic Cancer Action Network testing multiple experimental arms efficiently against common controls (1). Methods: Randomization is 70% (adaptive amongst experimental arms in sta
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Chakraborty, Rajshekhar, Lisa Rybicki, Jason Valent, et al. "Abnormal Metaphase Cytogenetics Adds to Currently Known Risk-Factors for Venous Thromboembolism in Multiple Myeloma: Derivation of the PRISM score." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-137525.

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Background: Prevention and management of venous thromboembolic events [VTE] is an important component of supportive care in newly diagnosed multiple myeloma [MM], especially in the era of immunomodulatory drugs [IMiDs]. Recently, two validated risk assessment models [RAMs], SAVED and IMPEDE-VTE, were developed to identify patients at high risk of VTE. However, these models have following limitations: (1) Patients were not uniformly treated in the era of contemporary MM therapy (2) Disease-specific variables were not available in the databases from which these scores were derived. Our primary a
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Sanz, M., C. M. Oñoro López, G. Bonilla, et al. "AB0376 DIFFERENCES IN IMMUNOGLOBULIN LEVELS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS AND RHEUMATOID ARTHRITIS TREATED WITH RITUXIMAB." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1315.1–1315. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4941.

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BackgroundHypogammaglobulinemia (HGGS) is one of the adverse effects of Rituximab (RTX), a chimeric monoclonal antibody directed against the CD20 receptor, frequently observed in ANCA-associated vasculitis (AAV) patients.ObjectivesTo study the characteristics of patients with AAV on RTX treatment and to analyze the factors associated with HGGS, as well as to compare them with patients with rheumatoid arthritis (RA) on the same treatment.MethodsRetrospective descriptive study of patients with a diagnosis of AAV or RA treated with RTX who had immunoglobulin levels prior to treatment and after ea
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43

Shah, Neil, Hagop Kantarjian, Andreas Hochhaus, et al. "Dasatinib Versus Imatinib In Patients with Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP) In the DASISION Trial: 18-Month Follow-up." Blood 116, no. 21 (2010): 206. http://dx.doi.org/10.1182/blood.v116.21.206.206.

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Abstract Abstract 206 Background: Dasatinib is 325-fold more potent than imatinib in vitro against unmutated BCR-ABL, and is an established second-line treatment for patients (pts) with CML-CP who are resistant, intolerant or have a suboptimal response to imatinib. The Phase 3 DASISION study compares dasatinib with imatinib as initial treatment for pts with newly diagnosed CML-CP. After a minimum of 12 months (mos) of follow-up, dasatinib 100 mg once daily demonstrated significantly higher and faster rates of complete cytogenetic response (CCyR) and major molecular response (MMR) compared to i
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44

Zhu, H., X. Q. Niu, W. W. Song, et al. "First Report of Leaf Spot of Tea Oil Camellia (Camellia oleifera) Caused by Lasiodiplodia theobromae in China." Plant Disease 98, no. 10 (2014): 1427. http://dx.doi.org/10.1094/pdis-11-13-1166-pdn.

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Tea oil camellia (Camellia oleifera Abel.), one of the most famous woody oil plants, is distributed and cultivated widely in central and southern China for its strong adaptability. In September 2013, tea oil camellia plants with severe leaf spots were observed in commercial production fields located in Wenchang, Hainan Province. Spots were initially chlorotic, became necrotic and black with a chlorotic halo, developing to cover the entire width of the leaves, and leading to leaf death. Isolations were performed by excising pieces of symptomatic leaves from the lesion margin, surface sterilized
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45

Swiecki, T. J., E. A. Bernhardt, and M. Garbelotto. "First Report of Root and Crown Rot Caused by Phytophthora cinnamomi Affecting Native Stands of Arctostaphylos myrtifolia and A. viscida in California." Plant Disease 87, no. 11 (2003): 1395. http://dx.doi.org/10.1094/pdis.2003.87.11.1395b.

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Ione manzanita (Arctostaphylos myrtifolia) is a rare, endemic, evergreen shrub restricted to Ione formation soils (infertile, acidic, sedimentary oxisols) in the foothills of the Sierra Nevada. The widely distributed A. viscida (whiteleaf manzanita) intermixes with A. myrtifolia at the margins of Ione formation soils. In 2002, we observed extensive mortality within two mixed stands of A. myrtifolia and A. viscida near Ione, CA. At one site, nearly all plants of both species in a 0.25-ha area had died recently. At a second site, most of the A. myrtifolia and A. viscida plants on several hectare
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46

Ceballos Bejarano, Ferdinand, Rosa Maria Vela Aquize, and Teresa Yanez Fernandez. "Analysis of Sexism in University Students." Universidad Ciencia y Tecnología 26, no. 112 (2022): 26–33. http://dx.doi.org/10.47460/uct.v26i112.542.

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A study is presented that analyzed the characteristics of sexism; a descriptive, non-experimental cross-sectional methodology was used. The sample consisted of 3004 randomly chosen university students. A measurement scale with 12 items was used that allowed us to understand the current situation of the students in relation to sexism. The results indicate that sexism in university students is low, statistically significant differences were found between men and women, however, both groups present low scores. Likewise, there are differences in sexism by professional career, where engineering stu
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Peters, Anthea C., Segun M. Akinwumi, Marco Iafolla, Curtis Mabilangan, Karen Doucette, and Jutta Preiksaitis. "Epidemiology Of Post-Transplant Lymphoproliferative Disorders Following Solid Organ Transplant In a Major Canadian Transplant Centre." Blood 122, no. 21 (2013): 4281. http://dx.doi.org/10.1182/blood.v122.21.4281.4281.

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Abstract Post-transplant lymphoproliferative disorder (PTLD) is a consequence of organ transplantation with a high risk of mortality. We analyzed records of all patients who received a solid organ transplant at the University of Alberta between 1984 and 2011 (n=4525). 133 patients developed PTLD over the follow up period of January 1984 to November 2012, including 61 cases that occurred less than 2 years after transplant ( early), 33 cases between 2 and 7 years after transplant (late), and 39 cases more than 7 years after transplant (very late). We calculated the cumulative incidence rate for
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48

Dhanawat, Aditya, Bhagyashri Jadhav, Atul Tiwari, et al. "BEP in intermediate- and poor-risk advanced non-seminomatous germ cell tumor (NSGCT): Standing the test of time." Journal of Clinical Oncology 43, no. 16_suppl (2025): 5026. https://doi.org/10.1200/jco.2025.43.16_suppl.5026.

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5026 Background: Bleomycin, etoposide, and cisplatin (BEP) has been the cornerstone of treatment for advanced NSGCT for decades. With the advent of newer regimens such as VIP (Etoposide, ifosfamide and cisplatin) and improved outcomes over the years, it is imperative to assess whether BEP has truly stood the test of time, especially for those in the intermediate and poor risk. Methods: This was a retrospective analysis of a prospectively collected dataset of NSGCT patients treated at a comprehensive cancer care centre in India. Adolescent and adult males with intermediate or poor-risk as per I
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Chen, Y. F., and Y. F. Fang. "AB0131 ASSOCIATION OF CYTOKINE AND CLINICAL EVALUATION BASED ON ULTRASOUND OF SALIVARY GLAND GRADE CLASSIFICATION IN PATIENTS WITH EARLY PRIMARY SJÖGREN’S SYNDROME." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1245.1–1245. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2174.

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BackgroundPrimary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, the presence of anti-SSA/Ro, anti-SSB/La antibody and hypergammaglobulinemia.ObjectivesTo investigate the clinical manifestations in patients with early primary Sjögren’s syndrome (pSS), and cytokine difference based on the severity score under salivary gland ultrasonography.MethodsForty-six newly diagnosed patients with early pSS were enrolled and divided into mild (score 0-1) and severe (score 2-3) groups according to the salivary gland ultrasonography
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Tymms, K., B. Butcher, T. Sletten, et al. "POS0906 PREVALENCE OF SLEEP DISTURBANCE IN PATIENTS WITH ANKYLOSING SPONDYLITIS WITHIN THE AUSTRALIAN CLINICAL SETTING (ASLEEP STUDY): A REAL-WORLD OBSERVATIONAL STUDY USING THE OPAL DATASET." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 711–12. http://dx.doi.org/10.1136/annrheumdis-2021-eular.578.

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Background:Sleep disorders are more prevalent in patients with ankylosing spondylitis (AS) compared to the general population. Sleep disturbance in AS, in addition to pain and fatigue, can lead to impaired physical function and reduced quality of life.Objectives:The primary objective was to determine the prevalence of sleep disturbance in patients with AS in a real-world Australian cohort using the Insomnia Severity Index (ISI) and Multivariate Apnoea Prediction Index (MAPI). ISI score of ≥ 15 is considered clinical insomnia. MAPI values below 0.05 are suggestive of clinical apnoea.Methods:Rou
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