Relevant bibliographies by topics / 5275r

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  2. Dissertations / Theses
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Academic literature on the topic '5275r'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "5275r"

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Singh, Sukhpal. "Book review: R. S. Ghuman and R. Sharma. 2018. Emerging Water Insecurity in India: Lessons from an Agriculturally Advanced State." Millennial Asia 10, no. 2 (July 29, 2019): 232–36. http://dx.doi.org/10.1177/0976399619853725.

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R. S. Ghuman and R. Sharma. 2018. Emerging Water Insecurity in India: Lessons from an Agriculturally Advanced State. New Castle Upon Tyne, UK: Cambridge Scholars Publishing, pp. xxvi+298, ISBN (10): 1-5275-1144-8, ISBN (13): 978-1-5275-1144-6.
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Rose, Ellen. "A Way Through the Global Techno-Scientific Culture, Sheldon Richmond (2020)." Explorations in Media Ecology 20, no. 3 (September 1, 2021): 361–63. http://dx.doi.org/10.1386/eme_00101_5.

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Review of: A Way Through the Global Techno-Scientific Culture, Sheldon Richmond (2020) Newcastle upon Tyne: Cambridge Scholars Publishing, 197 pp., ISBN13: 978-1-52754-626-4, h/bk, £61.99, Kindle, $9.99
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Mitra, Sandipan. "Book review: Social Justice and Legal Education. Edited by Chris Ashford and Paul Mckeown." Asian Journal of Legal Education 5, no. 2 (June 21, 2018): 186–89. http://dx.doi.org/10.1177/2322005818782563.

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Nagla, B. K. "Book review: Satish Sharma, Quakerism, Its Legacy, and Its Relevance for Gandhian Research." Sociological Bulletin 67, no. 2 (July 4, 2018): 239–41. http://dx.doi.org/10.1177/0038022918775447.

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Satish Sharma, Quakerism, Its Legacy, and Its Relevance for Gandhian Research. Newcastle upon Tyne, UK: Cambridge Scholars Publishing, 2017, xvi + 316 pp., £64.99 (hardback). ISBN (10): 1-5275-0010-1.
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Nick, I. M. "Naming, Identity, and Tourism." Names 69, no. 3 (August 16, 2021): 57–62. http://dx.doi.org/10.5195/names.2021.2312.

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Derham, Reem Ali Al. "The Role of the Social Media in Empowering Saudi Women’s Expression, Hend T. Alsudairy (2020)." Journal of Arab & Muslim Media Research 14, no. 1 (April 1, 2021): 160–62. http://dx.doi.org/10.1386/jammr_00030_5.

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PETERSEN, ALAN. "David Jackson , Exploring Aging Masculinities: The Body, Sexuality and Social Lives. Palgrave Macmillan, Basingstoke, UK, 2016, 201 pp., hbk £63, ISBN 13: 978-1-137-52756-1 (hbk), 978-1-137-52758-5 (e-book)." Ageing and Society 37, no. 7 (July 7, 2017): 1529–30. http://dx.doi.org/10.1017/s0144686x17000459.

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Cheng, Long, Cheng-Dong Wu, Yun-Zhou Zhang, and Yan Wang. "An Indoor Localization Strategy for a Mini-UAV in the Presence of Obstacles." International Journal of Advanced Robotic Systems 9, no. 4 (October 2012): 153. http://dx.doi.org/10.5772/52754.

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Lai, Jizhou, Pin Lv, Jianye Liu, and Bin Jiang. "Noncommutativity Error Analysis of Strapdown Inertial Navigation System under the Vibration in UAVs." International Journal of Advanced Robotic Systems 9, no. 4 (October 2012): 136. http://dx.doi.org/10.5772/52758.

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Stojcsics, Dániel, and András Molnár. "AirGuardian – UAV Hardware and Software System for Small Size UAVs." International Journal of Advanced Robotic Systems 9, no. 5 (November 2012): 174. http://dx.doi.org/10.5772/52759.

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Dissertations / Theses on the topic "5275r"

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Martin, Patrick. "Étude du transport et de la formation de particules pendant l'étape microélectronique de gravure assistée plasma." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10233.

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Dans l'industrie de la microelectronique, la contamination particulaire est responsable d'une reduction importante des performances des procedes de fabrication. Les procedes assistes plasma, et notamment les procedes de gravure seche sont une source particulierement nefaste de contamination particulaire. Nos travaux nous ont conduit, tout d'abord, a mettre au point et a evaluer des moyens in-situ (diffusion de la lumiere, mesure electriques) pour caracteriser la dimension et la densite des particules. Grace a ces dispositifs, nous avons etudie le transport des particules lors de l'etape critique pour la contamination des substrats en cours de traitement que constitue l'extinction du plasma. Nous avons ensuite analyse la formation des particules dans des plasmas d'argon (pulverisation) et des plasmas de trifluoromethane (gravure ionique reactive). La derniere partie de nos travaux est consacree a l'analyse de l'efficacite des procedes de nettoyage des reacteurs par des plasmas pulses
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Howard-Jones, Rachel Anne. "Oral progenitor cells as cell-based treatment for neural damage." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/52753/.

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Over the past few decades stem cells have been extensively investigated due to their potentially invaluable therapeutic use. Embryonic stem cells (ESCs) have wide-ranging therapeutic applications in tissue repair and regeneration due to their pluripotent properties and their ability to self-renew indefinitely. However, ethical concerns surround their use and hence alternatives are sought. Adult stem cells (ASCs) have been isolated from various adult tissues including the oral mucosa lamina propria (OMLP). This study aims to isolate ASCs from the OMLP, reprogram these cells to induced pluripotent stem cells (iPSCs) and determine the potential for both to differentiate into functional neurons due to the limited regeneration of neurons in the central nervous system. Such investigations into strategies for the treatment of neural damage are invaluable and timely due to current limitations in the availability of human-derived cells for potential autologous or allogeneic tissue repair. OMLP-PCs represent an ideal cell source for use in regenerative medicine given their ease of isolation, proliferative potential, multipotent properties and immunosuppressive activities. Work in this Thesis has now demonstrated that these oral progenitors expressed numerous pluripotency markers and for the first time, that they could be reprogrammed to iPSCs utilising safer, non-integrating plasmids, thus increasing their potential for use in clinical applications. OMLP-iPSCs were positive for a number of pluripotent stem cell markers including SSEA-4, SSEA-5, TRA-1-60, TRA-1-81, Oct-4 and Sox-2. Moreover, their expression of early stage germ layer markers indicated their potential to differentiate into cell types of the mesoderm, endoderm and ectoderm. OMLP-PCs were also demonstrated within this Thesis to differentiate down an early neural lineage as evidenced by the presence of typical neural markers (Nestin, βIII tubulin, MAP-2 and NF-M). The presence of both ligand-gated and voltage-sensitive calcium channels indicated some limited potential functional phenotype. Unfortunately, utilising the same neural differentiation methodology, OMLP-iPSCs were not able to be similarly driven down a neural pathway. None-the-less this data suggests that OMLP-PCs and OMLP-iPSCs may hold great promise for a wide range of regenerative medicine applications
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Almahasneh, Fatimah. "Effects of VEGF-A165b and SRPK1 inhibition on pain behaviour, cyclooxygenase expression and glial activation in the CNS in a model of osteoarthritis." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52753/.

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Background: Osteoarthritis (OA) is the most common musculoskeletal disease worldwide and a major cause of chronic pain. Treatment of OA pain is still suboptimal due to limited efficacy and considerable side effects of available analgesics. Pain in OA has a significant central component. Cyclooxygenases (COXs) and glial cells in the spinal cord and the periaqueductal gray (PAG) play a significant role in central sensitisation and pain modulation. Vascular endothelial growth factor-A (VEGF-A) is a key molecule in normal and pathological angiogenesis. Serine arginine protein kinase 1 (SRPK1), which phosphorylates serine arginine splice factor 1 (SRSP1), controls VEGF gene alternative splicing. This results in two splice variants; VEGF-A165a, which is pro-angiogenic and pro-nociceptive, and anti-angiogenic VEGF-A165b, which showed anti-nociceptive effects in models of neuropathic and inflammatory pain. Objective: This thesis investigated changes in COX expression and glial activation in the spinal cord and the PAG in the monosodium iodoacetate (MIA) model of OA. It also addressed the effects of VEGF-A165b and SRPK1 inhibitor SPHINX-31 on pain behaviour and joint pathology, as well as COX expression and glial activation in the spinal cord and the PAG in the same model. Hypothesis: VEGF-A165b and SPHINX-31 can prevent and/or reverse enhanced pain behaviour in the MIA model of OA, through involvement of spinal glial cells and COXs in the PAG and spinal cord. Vascular-astrocyte association in the PAG is enhanced in the MIA model of OA, and this effect is reversed by administration of SPHINX-31. Methods: Rats received an intra-articular injection of MIA (1 mg) in the knee. In one study, animals were treated with VEGF-A165b (i.p. 20 ng/g body weight twice weekly) on days 0-13 (VEGF(d0-13) group) or days 14-28 (VEGF(d14-28) group) after MIA injection; in another study, rats received SPHINX-31 (i.p. 0.8 µg/g body weight twice weekly; (MIA/SPHINX group)) for 19 days after induction of the model. Pain behaviour was monitored throughout the studies, at the end of which (day 28) tissues were collected for the assessment of joint histopathology and the evaluation of spinal COX-2 mRNA expression by PCR. In addition, immunofluorescence (IF) was used to assess COX-2 expression and glial activation in the spinal cord, as well as astrocyte activation and vascular-astrocyte association in the PAG. Results: VEGF-A165b significantly attenuated weight bearing asymmetry (%) in MIA rats on day 28 (29.58 ± 1.803 in MIA/VEGF(d0-13) group vs. 22.95 ± 2.088 in MIA/PBS group, p < 0.01; 29.23 ± 1.49 in VEGF(d14-28) vs. 22.95 ± 2.088 in MIA/PBS, p < 0.05). VEGF-A165b reversed mechanical withdrawal thresholds to the naïve level, but without reaching statistical significance. No significant changes in knee joint pathology were observed in VEGF-A165b treated MIA rats compared to the MIA/PBS counterparts. In the MIA/VEGF(d0-13) group, contralateral deep laminae of the dorsal horn had a higher percentage (%) of non-neuronal cells expressing COX-2 than the corresponding superficial laminae (3.26 ±1.16 vs 1.12 ± 0.43, p < 0.05), while no difference was observed in the MIA/PBS group. Administration of VEGF-A165b did not significantly affect spinal microglia and astrocyte activation, nor COX-2 expression in the PAG. SPHINX-31 had no significant effects on pain behaviour, joint pathology or spinal COX-2 expression in the MIA model of OA. On the other hand, MIA/SPHINX group exhibited a higher activation of spinal microglia than MIA controls (% of CD11b +ve cells in MIA/SPHINX-31 vs MIA/vehicle groups: 6.36 ± 0.89 vs 1.72 ± 0.38, p < 0.01). In addition, SPHINX-31 significantly increased astrocyte activation in the ipsilateral dorsolateral (DL) PAG relative to corresponding ventrolateral (VL) PAG (GFAP IF intensity: 12.89 ± 1.52 vs 8.46 ± 0.84, p < 0.05), and it increased vascular-astrocyte association (%) in the contralateral DL PAG relative to corresponding VL PAG (70.35 ± 7.68 vs 38.92 ± 8.19, p < 0.05). Interestingly, naïve rats had a significantly higher astrocyte activation and vascular-astrocyte association in the VL PAG than in DL PAG. Conclusions: VEGF-A165b exerted a significant antinociceptive effect in the MIA model of OA without affecting joint pathology, spinal glial cell activation or COX-2 expression in the PAG. SPHINX-31 did not reverse pain behaviour, but showed a potential effect on astrocyte activation and vascular-astrocyte association in the DL PAG relative VL PAG in the MIA model of OA.
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Clark, Ian. "Continuous synthesis and characterisation of layered double hydroxide nanomaterials for their application for dye wastewater remediation." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52758/.

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The first part of this research was aimed to improve continuous synthesis of LDHs through a matrix of experiments that investigated the influence of key factors affecting synthesis. These factors; temperature, pressure and reactant concentration were investigated for Ca2Al-NO3 LDHs. Alteration of reaction temperature and pressure caused changes to crystal domain length (CDL). As temperature was increased, tune-ability through pressure manipulation was lessened. The effect of the NaOH concentration in the precipitation reaction was found to have an impact on CDL. The highest NaOH concentration was found to produce smaller domain lengths. The initial excess of OH- causes nucleation of crystals to occur preferentially over sustained growth. High NaOH content caused Ca(OH)2 and Ca2Al-CO3 contamination, due to an excess of Ca2+ in the precursors and excess NaOH in the reaction. The presence of the impurities alter the chemical makeup of the compounds and the thermal properties. The effect of the changes to CDL was not realised in the other physical characteristics of the LDH, as platelet size remained at an average 2-5μm with no trend corresponding to CDL variations. Specific surface area (SBET) also showed no change in relation to CDL variation or the modification of reaction temperature, pressure or precursor NaOH. Scale up synthesis of LDHs focused on Zn2Al-CO3. Reactions to produce Zn2Al-CO3 were carried out at bench, pilot and industrial scale. All variables were kept constant, bar the reactor size and the flow rate. The pilot scale reactor operated at 20-30 times greater than bench scale. The pilot scale LDH exhibited greater CDL, this was attributed primarily to a settling period post-reaction, where the suspension was allowed to settle in the reaction liquor. Platelet diameter increased from 120nm at bench to 177nm at pilot scale and 165nm at industrial scale. The changes to particle size do not correspond with changes to SBET. Surface area decreased from 58m2 g-1 to 50m2 g-1 between bench and pilot synthesis but the surface area was recorded at 64,1m2 g-1 for the industrial Zn2Al-CO3 Industrial synthesis produced a Zn2Al-CO3 LDH with CDL (19nm) comparable to the bench scale sample (18nm) but smaller than the pilot scale sample (26nm). Zn2Al-CO3 LDHs for remediation of a synthetic dye was carried out on two types of reactive dye. The LDH was calcined and the resulting mixed metal oxide (MMO) was characterised. Calcination caused an increase in SBET from 50m2 g-1 to 57m2 g-1. Wet storage of the MMO reformed the LDH crystal phase, partly after 2 weeks and completely after 6 weeks. Adsorption of dye was best modelled by the Langmuir isotherm. The fit of the isotherm model was reduced as adsorption temperature was increased, due to inhibited uptake of dye at low initial concentration (C0). The maximum uptake capacity (qm) at 293K, was 589mg g-1 and 895mg g-1 for Reactive Black 5 and Reactive Orange 16, respectively. Adsorption was also modelled kinetically by a pseudo 2nd order model. Investigation of the impact of competing anions found that, Cl- had no effect on adsorption of either dye molecule, however addition of Na2CO3 and Na2SO4 inhibited adsorption. Thermal regeneration of the adsorbent significantly reduced the adsorption capacity in subsequent cycles. Washing with Na2CO3 prior to re-calcination mitigated the effect of regeneration. Breakthrough curves were fit with the Yoon-Nelson and Thomas models best, while the Adams-Bohart model was not appropriate. The adsorption capacity (qe) from the Thomas model was between 7.2mg g-1 and 7.6mg g-1, which is considerably lower compared with the batch scale Langmuir qm value. The reduction is attributed to a number of factors. The empty bed contact time was not enough to allow the adsorption to occur completely and breakthrough occurred after the first, timed sample. The presence of the PMMA in the granules may block adsorption sites also bind the particles, inhibiting the ability to expand and reform LDH layers with the dye molecules in the interlayer gallery. PMMA is also a hydrophobic which will contribute to a reduced interface between the MMO surface and the adsorbate solution. Continuous synthesis of LDH composites was carried out in a two-stage reactor system. The core@shell composites were designed to combine properties of the core with the adsorptive capacity of LDHs. For this research ZnO was chosen as the core material due to its photocatalytic capabilities, and Mg2Al-CO3 was chosen for the shell, due to the large Ca2Al-NO3 particles. Zn2Al-CO3 would be difficult to distinguish from the ZnO in chemical analysis. The composite exhibited reflections relating to both ZnO and the Mg2Al-CO3 in the diffractogram. The SBET of the composite (75m2 g-1) was greater than each of the individual materials and a dry mixture of LDH and ZnO powders. There is a reduction in Mg/Al ratio of the LDH from 2:1 to closer to 1:1. This was first attributed to the potential for Zn2Al-CO3 LDH production in the second reactor from residual Zn2+ ions or dissolution of ZnO. However, further examination of synthesis in the second reactor indicated that NaOH concentration has a dramatic effect on Mg(OH)2 precipitation. Low NaOH caused Al(OH)3 to be prevalent in the brucite-like sheets. This may phenomenon may occur in composite synthesis. Increased Al(OH)3 distorts the layers and caused an increase in SBET to 250m2 g-1. The synthesis of ZnO@LDH composite materials was partially successful as there appears to be some degree of bonding between ZnO cores and Mg2Al-Co3 LDH shells. However, more work to fine tune continuous composite synthesis is required, as there is in some instances a mixture of LDH and ZnO nanoparticles that are not part of a composite material.
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Fox, Nathan Josephe. "The intuition of knowing : its biological function and natural triggering-conditions." Thesis, Open University, 2017. http://oro.open.ac.uk/52753/.

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Over the last hundred years, competing and incompatible positions in relation to basic problems of knowledge and the use of the verb ‘to know’ have multiplied; and the prospect of a consensus solution emerging with respect to any of the problems has not seemed particularly good. We have a Gordian knot. Even so, I suggest that we also have a way to cut it. This will involve identifying why the cognitive mechanism that produces our intuitions of knowing evolved and was maintained (by natural selection), i.e., identifying the ‘teleonomic function’ of that cognitive mechanism. Also, it will involve predicting, on the basis of this teleonomic function, the triggering-conditions of these natural knowledge intuitions. In this thesis, I develop a general theory of the origin, function and triggering-conditions of knowledge intuitions that will allow us to cut that knot. That theory follows basic biological theory (including that which pertains to natural altruism) and also signal detection theory. My theory identifies a number of different circumstances under which the triggering-conditions of knowledge intuitions are different. Strikingly, these different circumstances (and their associated triggering-conditions) map onto the different competing and incompatible epistemological positions to which I referred. This suggests that these positions are all correct within the boundaries of one of the circumstances that my theory identifies; and that the Gordian knot is largely the result of epistemologists claiming universal applicability of a theory that in fact only applies under particular circumstances. We cut the knot by specifying the different circumstances under which each of the different epistemological positions will hold, and the reason we should expect it to hold in just these circumstances, in light of the teleonomic function of knowledge intuitions.
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Touchais, Emmanuelle. "Étude et développement d'une source de plasma micro-onde pour déposer des revetements par pulvérisation sur des grandes surfaces." Grenoble INPG, 1996. http://www.theses.fr/1996INPG0106.

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Les caracteristiques d'une nouvelle source de plasma pour le depot de revetements par pulverisation sur des grandes surfaces ont ete etudiees. Cette source utilise une onde electromagnetique de frequence 2. 45 ghz pour accelerer les electrons qui ionisent les atomes d'argon par impact electronique. Un champ magnetique permet de confiner les electrons pour d'une part optimiser le couplage avec l'onde en tout lieu ou il est egal a 875 gauss et d'autre part transporter le plasma vers une cible de pulverisation polarisee negativement. Une source produisant une nappe de plasma de section rectangulaire de 75 cm2 a ete realisee. La caracterisation du plasma a ete effectuee en termes de densite electronique par interforemetrie, de temperature electronique par mesure de sonde et de courant d'ions recueillis sur la cible en fonction des parametres puissance micro-onde, pression d'argon, champ magnetique. Les valeurs obtenues ont montre que ce plasma est dense, avec une independance entre les parametres de creation du plasma et ceux de la pulverisation. L'usure des cibles de pulverisation est uniforme et correspond a l'intersection entre les lignes de champ magnetique et la surface de la cible. L'etude des couches de chrome deposees par ce procede a montre que la diminution de la pression permet d'obtenir des couches de densite proche de celle du chrome massique, avec des vitesses de depot elevees, et des contraintes residuelles faibles. Sous pression reduite constante, l'incorporation de carbone dans les couches de chrome par pulverisation reactive a permis d'augmenter la durete de ces couches. La morphologie devient plus dense, avec des contraintes residuelles faibles et une resistivite electrique faible. D'autres revetements (fer, oxyde de chrome, oxyde d'aluminium) ont ete realises pour demontrer la potentialite de ce nouveau dispositif a deposer en tension de polarisation negative continue de la cible des materiaux magnetiques et des oxydes
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D’Alessandro, Teresa <1982&gt. "Development of newly conceived biomimetic nano-structured biomaterials as scaffolds for bone and osteochondral regeneration." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5275/.

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The present research thesis was focused on the development of new biomaterials and devices for application in regenerative medicine, particularly in the repair/regeneration of bone and osteochondral regions affected by degenerative diseases such as Osteoarthritis and Osteoporosis or serious traumas. More specifically, the work was focused on the synthesis and physico-chemical-morphological characterization of: i) a new superparamagnetic apatite phase; ii) new biomimetic superparamagnetic bone and osteochondral scaffolds; iii) new bioactive bone cements for regenerative vertebroplasty. The new bio-devices were designed to exhibit high biomimicry with hard human tissues and with functionality promoting faster tissue repair and improved texturing. In particular, recent trends in tissue regeneration indicate magnetism as a new tool to stimulate cells towards tissue formation and organization; in this perspective a new superparamagnetic apatite was synthesized by doping apatite lattice with di-and trivalent iron ions during synthesis. This finding was the pin to synthesize newly conceived superparamagnetic bone and osteochondral scaffolds by reproducing in laboratory the biological processes yielding the formation of new bone, i.e. the self-assembly/organization of collagen fibrils and heterogeneous nucleation of nanosized, ionically substituted apatite mimicking the mineral part of bone. The new scaffolds can be magnetically switched on/off and function as workstations guiding fast tissue regeneration by minimally invasive and more efficient approaches. Moreover, in the view of specific treatments for patients affected by osteoporosis or traumas involving vertebrae weakening or fracture, the present work was also dedicated to the development of new self-setting injectable pastes based on strontium-substituted calcium phosphates, able to harden in vivo and transform into strontium-substituted hydroxyapatite. The addition of strontium may provide an anti-osteoporotic effect, aiding to restore the physiologic bone turnover. The ceramic-based paste was also added with bio-polymers, able to be progressively resorbed thus creating additional porosity in the cement body that favour cell colonization and osseointegration.
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Odularu, Gbadebo Olusegun Abidemi. "An economic development strategy for West Africa : lessons and policy directions." Thesis, University of Sunderland, 2013. http://sure.sunderland.ac.uk/5275/.

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This thesis presents existing published work examining the coherent theme of the pertinent issues on economic development in West Africa. The seven distinct and thematically related papers span over six years of study into the issues relating to the socio-economic context of development in West Africa. Each of the papers discusses salient aspects of regional development in selected West African economies. This thesis has contributed to knowledge in the academic literature on: • The importance of health-responsive development policies in enhancing agricultural transformation. • The role of crude oil in augmenting economic performance. • The importance of export diversification in fostering intra-trade expansion and economic growth. • The role of agricultural trade policy options in facilitating economic expansion: the case of rice. • The contribution of standards to enhancing market access and economic development: the cocoa case study. • The importance of the African Growth Opportunity Act (AGOA) in promoting market access and economic performance. • The contribution of Saemaul Undong Model to enhancing rural development policy space. The thesis has attempted to provide an answer to the question: How can regional economic development be achieved in West Africa? The critical review and analyses of the issues examined in each of the papers provide deep insights into the drivers of economic transformation in West Africa. In an attempt to respond to this research question, this thesis proposes a workable strategy for fostering economic development, but cautions that the success of the strategy is contingent on a strong political will, coupled with an effective coordination and cooperation at national and regional levels. The thesis concludes that the proposed transformation plan must be innovation led by strategically reconstructing the rural communities where economic potentials are yet to be exploited.
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Waring, Sara. "An examination of the impact of accountability and blame culture on police judgments and decisions in critical incident contexts." Thesis, University of Liverpool, 2011. http://livrepository.liverpool.ac.uk/5275/.

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The following thesis examines the impact of accountability on police judgments and decisions within critical incident contexts. Previous accountability research has often failed to balance experimental control with naturalistic context, thereby preventing the development of an integrated socio-cognitive model. Despite the increase in police accountability over the last few decades (Punch, 2009), there has also been a lack of systematic focus on the influence this evaluation mechanism has on policing. Level of risk posed to public safety in critical incidents and the potential for police actions to increase as well as decrease this risk heightens the importance of identifying and understanding factors that influence police judgments and decisions (Ask & Granhag, 2005). Overall, the thesis seeks to both advance theoretic development and highlight practical implications for policing using a combination of experimental and naturalistic methods and theories from traditional, organisational and naturalistic decision paradigms. Research conducted therefore acknowledges the complexity of policing contexts whilst distinguishing the influence of accountability from other factors. In total, five data chapters are presented that comprise of both qualitative and quantitative data. Qualitative data consists of transcripts from electronic focus groups, debriefs and questionnaires that are analysed using thematic analysis. Quantitative data consists of police responses to a vignette and a simulation. Findings indicate that accountability may influence police judgments and decisions by altering emotions, motivational goals and attention focus. The influence of this social mechanism may depend on police perceptions of the organisational culture driving the form accountability takes. This thesis will highlight that accountability is most likely to encourage optimal performance when police view the organisation to provide a supportive environment with legitimate and fair appraisal mechanisms. This is in contrast to an unfair, illegitimate environment driven by a culture of blame. Within a supportive environment, police are more likely to be motivated by accuracy than self-preservation. A supportive environment also encourages attention to remain focussed on providing judgments and decisions suitable for the situation rather than becoming distracted by anxiety over the potential to be blamed and punished.
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Byrne, Ashleigh Maria. "Functional characterisation of phosphodiesterase 4D7 in prostate cancer." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5275/.

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3’,5’-cyclic adenosine monophosphate (cAMP) is the best studied intracellular second messenger. Adenylyl cyclase (AC) catalyses the synthesis of cAMP from ATP following the stimulation of a G protein coupled receptor (GPCR), and its degradation is catalysed by cAMP phosphodiesterases (PDEs) to allow cessation of signal. cAMP can act to bring about a multitude of varying and often opposing cellular responses, which depend on the stimulus received by the GPCR, the cell type, the cell cycle stage, and the complement of downstream effector molecules within that cell. The cAMP PDE subfamilies express multiple splice variants, which possess unique N-termini and non-redundant functional roles. By virtue of this, they are targeted to specific and discrete subcellular locations, where they may form highly specific interactions with scaffold proteins and other enzymes. Here, in these discrete locales, PDEs act to hydrolyse local cAMP, thereby underpinning the spatial and temporal compartmentalisation of cAMP gradients. This fine-tuned balance of synthesis and degradation is paramount for the dynamic cellular responses to extracellular stimuli, allowing differing signal transduction cascades to occur simultaneously in the crowded macromolecular environment of the cell. The compartmentalisation of cAMP signalling is, thus, essential for maintaining cellular homeostasis, and is subject to perturbation in various diseases, including prostate cancer (PC). Despite the wealth of literature implicating cAMP signalling in the progression of PC, little work has been done on the expression or function of PDE splice variant in this disease. Our group, in collaboration with Philips Research and the Prostate Cancer and Molecular Medicine (PCMM) group in the Netherlands, set out to investigate the changes in cAMP signalling during PC progression by studying the expression of cAMP PDE isoforms, with the aim of identifying a novel PC biomarker, as the current standard biomarker (PSA) is not disease-specific and leads to much over-diagnosis and over-treatment of otherwise non-life threatening prostate tumours. Interestingly, we found PDE4D7 to be dramatically downregulated as PC progresses from an androgen sensitive (AS) to an androgen insensitive (AI) state, and, indeed, this enzyme is showing promise as a novel, disease-specific PC biomarker. In this thesis, I report my efforts to characterise a function of PDE4D7 within prostate cancer. Firstly, I report the raising of a novel highly specific PDE4D7 antibody and describe the differential expression of this isoform, at the protein level, between AS and AI PC cell models. I present evidence to suggest that PDE4D7 mediates PC cell growth and migration, and that its loss may play a role in PC progression. I propose that an altered epigenome plays a role in the downregulation of PDE4D7 expression. I then report on the raising of a novel phospho-specific antibody and present evidence to show that PDE4D7 is regulated by PKA phosphorylation within its unique N-terminal region, and that this event confers negative regulation on enzyme activity. Finally, I describe my endeavours to elucidate a PDE4D7 protein-protein interaction that may help transduce PDE4D7-specific signals and maintain the enzymes cellular location.
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Books on the topic "5275r"

1

Börger, Egon, Hans Kleine Büning, and Michael M. Richter, eds. CSL '89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2.

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United States. Congress. House. Committee on Education and Labor. Congressional Award Amendments of 1990: Report (to accompany H.R. 5275) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1990.

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United States. Congress. House. Committee on Education and Labor. Congressional Award Amendments of 1990: Report (to accompany H.R. 5275) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1990.

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United States. Congress. House. Committee on Education and Labor. Congressional Award Amendments of 1990: Report (to accompany H.R. 5275) (including cost estimate of the Congressional Budget Office). [Washington, D.C.?: U.S. G.P.O., 1990.

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Berti, Riccardo. Victim-Offender Reconciliation in the People’s Republic of China and Taiwan. London: Palgrave Macmillan UK, 2016. http://dx.doi.org/10.1007/978-1-137-52754-7.

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Seifert, Irmgard, Thomas Schnellbacher, and Johannes Buchmann. Praxis der Manuellen Medizin bei Säuglingen und Kindern. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-52750-4.

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Delorme, Stefan, Peter Reimer, Wolfgang Reith, Cornelia Schäfer-Prokop, Claudia Schüller-Weidekamm, and Markus Uhl, eds. Weiterbildung Radiologie. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-52752-8.

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Taghizadeh, Hadi. Pocket Guide Anästhesie. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-52754-2.

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Wunn, Ina, and Davina Grojnowski. Ancestors, Territoriality, and Gods. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-52757-3.

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Mareczek, Jörg. Grundlagen der Roboter-Manipulatoren – Band 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-52759-7.

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Book chapters on the topic "5275r"

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Ambos-Spies, Klaus, and Dongping Yang. "Honest polynomial-time degrees of elementary recursive sets." In Lecture Notes in Computer Science, 1–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_29.

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Antoniou, G., and V. Sperschneider. "On the verification of modules." In Lecture Notes in Computer Science, 16–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_30.

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Börger, Egon. "A logical operational semantics of full Prolog." In Lecture Notes in Computer Science, 36–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_31.

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Cantone, D., V. Cutello, and A. Policriti. "Set-theoretic reductions of Hilbert's tenth problem." In Lecture Notes in Computer Science, 65–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_32.

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Dahlhaus, Elias. "The complexity of subtheories of the existential linear theory of reals." In Lecture Notes in Computer Science, 76–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_33.

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Dahn, Bernd I. "On test classes for universal theories." In Lecture Notes in Computer Science, 90–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_34.

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Decker, Hendrik, and Lawrence Cavedon. "Generalizing allowedness while retaining completeness of SLDNF-resolution." In Lecture Notes in Computer Science, 98–115. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_35.

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Droste, Manfred, and Rüdiger Göbel. "Effectively given information systems and domains." In Lecture Notes in Computer Science, 116–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_36.

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Goerdt, Andreas. "Davis-Putnam resolution versus unrestricted resolution." In Lecture Notes in Computer Science, 143–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_37.

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Grädel, Erich. "On logical descriptions of some concepts in structural complexity theory." In Lecture Notes in Computer Science, 163–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3-540-52753-2_38.

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Conference papers on the topic "5275r"

1

Laginestra, Maria Antonella, Fabio Fuligni, Maura Rossi, Davide Gibellini, Maria Rosaria Sapienza, Anna Gazzola, Claudia Mannu, et al. "Abstract 5275: miRNA profiling of peripheral T-cell lymphomas." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5275.

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Yu, Kaixian, Yun Xu, Ke Tang, Albert Steppi, Jun Zhou, Zheng Ouyang, and Jinfeng Zhang. "Abstract 5275: An integrated pipeline for TCGA data analysis." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-5275.

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Tamayo, Lizeth I., Tatiana Vidaurre, Jeannie N. Vásquez, Sandro Casavilca, Jessica I. Palomino, Monica Calderon, Garth H. Rauscher, and Laura Fejerman. "Abstract 5275: Breast cancer characteristics among Indigenous American women from Peru." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5275.

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Rabin, Karen M. "Producing Interactive Environmental Impact Assessments on CD-ROM." In SPE/EPA Exploration and Production Environmental Conference. Society of Petroleum Engineers, 1999. http://dx.doi.org/10.2118/52751-ms.

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Daddario, David J. "Transforming Environmentally-Impacted Sites into Optimum Returns." In SPE/EPA Exploration and Production Environmental Conference. Society of Petroleum Engineers, 1999. http://dx.doi.org/10.2118/52753-ms.

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Heintz, John V., Bernardita Calinao, and Ryme Katkhouda. "Creation of an Integrated Environmental Information Management System for the Environmental Impact Evaluation of Petroleum Activities." In SPE/EPA Exploration and Production Environmental Conference. Society of Petroleum Engineers, 1999. http://dx.doi.org/10.2118/52755-ms.

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Ripaldi, Carl Peter. "Impacts of the Alameda Corridor Transportation Project in Metropolitan Los Angeles." In SPE/EPA Exploration and Production Environmental Conference. Society of Petroleum Engineers, 1999. http://dx.doi.org/10.2118/52756-ms.

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Zhang, Haitao, Ke Li, Masaei Ito, and Tony Collins. "Modeling of Carbon Nanotube Reinforced Rubber Seals." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52750.

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The increasing demand for oil and gas has incited exploration and production of deeper wells that reach high pressure and high temperature (HPHT) reservoirs. One critical element that is required to this end is rubber seals that can withstand HPHT conditions while meeting the requirements of sealability and structural integrity. Novel nanocomposites that comprise of natural rubber (NR) reinforced by well dispersed, high-concentration carbon nanotubes (CNTs) were recently developed to achieve the desired performance and were experimentally shown to exhibit significantly higher storage modulus than the matrix material. Understanding of the underlying reinforcing mechanism of this class of nanocomposites subjected to large deformation, especially in the real application conditions, has been very limited. In this study, a multiscale modeling method is developed to understand the mechanical behavior of CNT-rubber seals installed in a groove and subjected to high pressure. A micromechanics model is first constructed to evaluate the effective stress-strain responses of a representative volume element under different loading conditions, including uniaxial tension, equal biaxial extension, and planar tension. The effective properties thus established are then inputted into an appropriate hyperelasticity model, which is then used to model a CNT-rubber O-ring installed and pressurized. Sealability and structural integrity are evaluated in terms of contact pressure and strain. The numerical results are compared with the available experimental data. A parametric study is then conducted to assess the effects of CNT concentrations.
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Lotfi, Kourosh, Mohamed Ali Mosrati, Kerstin Willander, Ingrid Jakobsen Falk, Monica Hermanson, Martin Höglund, Dick Stockelberg, Yuan Wei, and Peter Söderkvist. "Abstract 5275: Association of TERT polymorphism with acute myeloid leukemia risk and prognosis." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5275.

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Rhoads, D. C., E. C. Revelas, and J. D. Germano. "Development Of A UV Fluorescence Imaging System For In-Situ Detection Of Petroleum In Marine Sediments." In Offshore Technology Conference. Offshore Technology Conference, 1986. http://dx.doi.org/10.4043/5275-ms.

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Reports on the topic "5275r"

1

Schroeppel, Richard Crabtree, Normand Arthur Modine, Anand Ganti, Lyndon George Pierson, and Christopher P. Tigges. Quantum computing accelerator I/O : LDRD 52750 final report. Office of Scientific and Technical Information (OSTI), December 2003. http://dx.doi.org/10.2172/918282.

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