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Journal articles on the topic '532.001 51'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Marcucci, Guido, C. D. Baldus, A. S. Ruppert, et al. "Overexpression of the ERG Gene Is an Adverse Prognostic Factor in Acute Myeloid Leukemia (AML) with Normal Cytogenetics (NC): A Cancer and Leukemia Group B Study (CALGB)." Blood 106, no. 11 (2005): 335. http://dx.doi.org/10.1182/blood.v106.11.335.335.

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Abstract Around 45% of adults with AML have NC and are included in an intermediate-risk group. However, their 5-year (yr) overall survival (OS) rates vary between 24 and 42%, likely due to the prognostic impact of submicroscopic genetic alterations, e.g., mutations in FLT3, CEBPA, MLL and NPM genes and overexpression of BAALC. We recently showed that ERG, an ETS-Related Gene mapped to 21q22, is often overexpressed in AML with unfavorable complex karyotypes, and in a subset of NC AML (PNAS2004;101:3915), suggesting that ERG overexpression contributes to an aggressive phenotype in AML. Here we a

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Gunderson, Leonard L., Daniel J. Sargent, Joel E. Tepper, et al. "Impact of T and N Stage and Treatment on Survival and Relapse in Adjuvant Rectal Cancer." Journal of Clinical Oncology 22, no. 10 (2004): 1785–96. http://dx.doi.org/10.1200/jco.2004.08.173.

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Purpose To determine survival and relapse rates by T and N stage and treatment method in five randomized phase III North American rectal adjuvant studies. Patients and Methods Data were pooled from 3,791 eligible patients enrolled onto North Central Cancer Treatment Group (NCCTG) 79-47-51, NCCTG 86-47-51, US Gastrointestinal Intergroup 0114, National Surgical Adjuvant Breast and Bowel Project (NSABP) R01, and NSABP R02. Surgery alone (S) was the treatment arm in 179 patients. The remaining patients received adjuvant treatment as follows: irradiation (RT) alone (n = 281), RT + fluorouracil (FU)

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Neben, Kai, Christian Giesecke, Silja Schweizer, Anthony D. Ho, and Alwin Krämer. "Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile." Blood 101, no. 1 (2003): 289–91. http://dx.doi.org/10.1182/blood-2002-04-1188.

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Abstract Genetic instability is a common feature in acute myeloid leukemia (AML). Centrosome aberrations have been described as a possible cause of aneuploidy in many human tumors. To investigate whether centrosome aberrations correlate with cytogenetic findings in AML, we examined a set of 51 AML samples by using a centrosome-specific antibody to pericentrin. All 51 AML samples analyzed displayed numerical and structural centrosome aberrations (36.0% ± 16.6%) as compared with peripheral blood mononuclear cells from 21 healthy volunteers (5.2% ± 2.0%; P &lt; .0001). In comparison to AML sa

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Robertson, Sarah E., Nina R. Joyce, Jon A. Steingrimsson, et al. "Comparing Lung Cancer Screening Strategies in a Nationally Representative US Population Using Transportability Methods for the National Lung Cancer Screening Trial." JAMA Network Open 7, no. 1 (2024): e2346295. http://dx.doi.org/10.1001/jamanetworkopen.2023.46295.

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ImportanceThe National Lung Screening Trial (NLST) found that screening for lung cancer with low-dose computed tomography (CT) reduced lung cancer–specific and all-cause mortality compared with chest radiography. It is uncertain whether these results apply to a nationally representative target population.ObjectiveTo extend inferences about the effects of lung cancer screening strategies from the NLST to a nationally representative target population of NLST-eligible US adults.Design, Setting, and ParticipantsThis comparative effectiveness study included NLST data from US adults at 33 participat

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Satoko, Morishima, Koichi Kashiwase, Fumihiro Azuma, et al. "Impact Of HLA Allele and Haplotype On Acute Graft-Versus-Host Disease and Survival After Hematopoietic Stem Cell Transplantation From Unrelated Donor." Blood 122, no. 21 (2013): 708. http://dx.doi.org/10.1182/blood.v122.21.708.708.

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Abstract Background Although the effect of allele matching of each HLA locus on the clinical outcome of unrelated hematopoietic stem cell transplantation (UR-HSCT) has been characterized, the effect of HLA allele or haplotype (HP) itself has not been well elucidated. The HLA region is recognized as one of the most important genetic regions associated with human disease, especially autoimmune and infectious diseases. We therefore hypothesized that the immunological response and the clinical outcome following UR-HSCT depend not only on HLA allele matching but also on the HLA allele itself or HLA

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Prochaska, Judith J., Erin A. Vogel, Amy Chieng, et al. "A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study." Journal of Medical Internet Research 23, no. 3 (2021): e24850. http://dx.doi.org/10.2196/24850.

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Background Misuse of substances is common, can be serious and costly to society, and often goes untreated due to barriers to accessing care. Woebot is a mental health digital solution informed by cognitive behavioral therapy and built upon an artificial intelligence–driven platform to deliver tailored content to users. In a previous 2-week randomized controlled trial, Woebot alleviated depressive symptoms. Objective This study aims to adapt Woebot for the treatment of substance use disorders (W-SUDs) and examine its feasibility, acceptability, and preliminary efficacy. Methods American adults

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Vollbrecht, Hanna, Vineet Arora, Sebastian Otero, Kyle Carey, David Meltzer, and Valerie G. Press. "Evaluating the Need to Address Digital Literacy Among Hospitalized Patients: Cross-Sectional Observational Study." Journal of Medical Internet Research 22, no. 6 (2020): e17519. http://dx.doi.org/10.2196/17519.

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Background Technology is a potentially powerful tool to assist patients with transitions of care during and after hospitalization. Patients with low health literacy who are predisposed to poor health outcomes are particularly poised to benefit from such interventions. However, this population may lack the ability to effectively engage with technology. Although prior research studied the role of health literacy in technology access/use among outpatients, hospitalized patient populations have not been investigated in this context. Further, with the rapid uptake of technology, access may no longe

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Li, Shan, Xianglu Zhu, Lin Zhu, Xin Hu, and Shujuan Wen. "Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case–control study." British Journal of Nutrition 124, no. 12 (2020): 1311–19. http://dx.doi.org/10.1017/s000711452000152x.

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AbstractLimited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL), and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case–control study enrolled 512 newly diagnosed (within 1 month) NHL patients and 512 healthy controls who were matched by age (±5 years) and sex in Urumqi, China. Serum carotenoid levels were measured by HPLC. Conditional logistic regression showed that higher serum total carotenoid levels and their

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Liu, Bennett M., Kelley Paskov, Jack Kent, et al. "Racial and Ethnic Disparities in Geographic Access to Autism Resources Across the US." JAMA Network Open 6, no. 1 (2023): e2251182. http://dx.doi.org/10.1001/jamanetworkopen.2022.51182.

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ImportanceWhile research has identified racial and ethnic disparities in access to autism services, the size, extent, and specific locations of these access gaps have not yet been characterized on a national scale. Mapping comprehensive national listings of autism health care services together with the prevalence of autistic children of various races and ethnicities and evaluating geographic regions defined by localized commuting patterns may help to identify areas within the US where families who belong to minoritized racial and ethnic groups have disproportionally lower access to services.Ob

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Moravcová, Katarína, Martina Karbanová, Maxi Pia Bretschneider, Markéta Sovová, Jaromír Ožana, and Eliška Sovová. "Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial." Nutrients 14, no. 10 (2022): 2005. http://dx.doi.org/10.3390/nu14102005.

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In this study, we evaluated whether the digital program Vitadio achieves comparable results to those of an intensive in-person lifestyle intervention in obesity management. This is a 12-month prospective, randomized controlled trial. Obese patients with insulin resistance, prediabetes or type 2 diabetes were included. The intervention group (IG) used Vitadio. The control group (CG) received a series of in-person consultations. Body weight and various metabolic parameters were observed and analyzed with ANOVA. The trial is ongoing and the presented findings are preliminary. Among 100 participan

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Mota, Jorge, Maria Paula Santos, and José Carlos Ribeiro. "Differences in Leisure-Time Activities According to Level of Physical Activity in Adolescents." Journal of Physical Activity and Health 5, no. 2 (2008): 286–93. http://dx.doi.org/10.1123/jpah.5.2.286.

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Background:The main goals of this study were: (1) to examine the relationship between physical activity (PA) involvement and other leisure activities in a sample of Portuguese youth and (2) to analyze gender differences in PA and leisure-time activity structure.Methods:The sample comprised 1123 adolescents that were classified according to PA levels as active (n = 589) and nonactive (n = 534). A questionnaire assessing leisure-time activities was used.Results:Girls were significantly more engaged in social leisure, dutiful, and individual artistic activities during leisure time, whereas boys w

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SINGH, MAN, and HIDEKI MATSUOKA. "EFFECT OF IONIC SIZES OF HALIDE ANIONS OF POTASSIUM SALTS ON SURFACE AND INTERFACIAL TENSIONS OF BENZENE AND WATER INTERFACES FOR MUTUAL MIXING." Surface Review and Letters 16, no. 05 (2009): 743–47. http://dx.doi.org/10.1142/s0218625x09013219.

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Surface tension (γ, mN/m) of potassium halide salts with water and interfacial tension (IFT) (±0.01 mN/m) of benzene interfaces with water are reported at 298.15 K temperature. The 0.1, 0.5 and 1.0 mol kg-1 potassium fluoride ( KF ), chloride ( KCl ), bromide ( KBr ) and potassium iodide ( KI ) solutions were studied. The KCl, KBr, KF and KI increased the surface tension by 5.2, 4.0, 3.1 and 3.0%, respectively, with salt–water interaction influence by anionic sizes. The surface tension of water from air–water to benzene–water interfaces is decreased by 51% due to the benzene–water mutual inter

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Hu, Qiaoyun, Haofei Wang, Philippe Goloub, et al. "The characterization of Taklamakan dust properties using a multiwavelength Raman polarization lidar in Kashi, China." Atmospheric Chemistry and Physics 20, no. 22 (2020): 13817–34. http://dx.doi.org/10.5194/acp-20-13817-2020.

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Abstract. The Taklamakan desert is an important dust source for the global atmospheric dust budget and a cause of the dust weather in East Asia. The characterization of Taklamakan dust in the source region is still very limited. To fill this gap, the DAO (dust aerosol observation) was conducted in April 2019 in Kashi, China. The Kashi site is about 150 km from the western rim of the Taklamakan desert and is strongly impacted by desert dust aerosols, especially in spring time, i.e., April and May. According to sun–sky photometer measurements, the aerosol optical depth (at 500 nm) varied in the

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Leon-Ferre, Roberto Antonio, Mei-Yin Polley, Heshan Liu, et al. "Prognostic value of histopathology, stromal tumor infiltrating lymphocytes (sTILs) and adjuvant chemotherapy (AdjCT) in early stage triple negative breast cancer (TNBC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 533. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.533.

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533 Background: Current guidelines define TNBC as complete absence of estrogen (ER) and progesterone receptor (PR), without HER2 amplification. However, the prognostic impact of clinical and histopathological factors, sTILs, and AdjCT in TNBC meeting these strict criteria is unknown. Methods: From a cohort of 9985 women who underwent upfront surgery for M0 breast cancer (BC) at Mayo Clinic Rochester from 1985-2012, 1159 pts with ER negative or low (≤10%) BC were identified for central ER/PR/HER2 staining and HER2 FISH (IHC2+ only) to select those with TNBC by modern definitions. Cox proportion

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Shi, Qiuling, Xin Shelley Wang, James M. Reuben, et al. "Chemotherapy-induced peripheral neuropathy in multiple myeloma patients undergoing maintenance therapy." Journal of Clinical Oncology 31, no. 15_suppl (2013): 9646. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.9646.

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9646 Background: After 3-months autologous stem cell transplant (AuSCT), a percentage of multiple myeloma (MM) patients during maintenance therapy continue to experience a complex of symptoms related to peripheral neuropathy. This longitudinal study examined these self-reported neuropathy symptoms and identified circulating inflammatory markers associated with high neuropathy-related symptoms. Methods: MM patients (N=51) rated symptom severity on 0-10 scale via the M. D. Anderson symptom Inventory (MDASI) weekly from 3 to 9 months post AuSCT during maintenance therapy. Patient also rated pain

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Мицура, Е. Ф., and Л. И. Волкова. "Prevalence and Annual Dynamics of Hemolytic Anemia in Children in the Republic of Belarus in 2005-2020." Гематология. Трансфузиология. Восточная Европа, no. 4 (December 29, 2021): 488–94. http://dx.doi.org/10.34883/pi.2021.7.4.010.

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Цель исследования. Оценить распространенность и годовую динамику гемолитических анемий (ГА) у детей в Республике Беларусь за период с 2005 по 2020 г. Материалы и методы. Использованы данные официальной статистической отчетности Республики Беларусь с 2005 по 2020 г. Учитывались следующие показатели в целом и отдельно по областям и возрастным группам: количество выявленных случаев ГА в детском и подростковом возрасте (0-17 лет), впервые выявленные случаи ГА в текущем году, количество детей с ГА, состоящих на диспансерном учете (ДУ) на конец года. Для расчета интенсивных показателей (на 100 тыс.

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Hosseinzadeh, Shayan, Ata M. Kiapour, Daniel A. Maranho, et al. "The metaphyseal fossa surrounding the epiphyseal tubercle is larger in hips with moderate and severe slipped capital femoral epiphysis than normal hips." Journal of Children's Orthopaedics 14, no. 3 (2020): 184–89. http://dx.doi.org/10.1302/1863-2548.14.200010.

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Purpose To compare the 3D morphology of the metaphyseal fossa among mild, moderate and severe stable slipped capital femoral epiphysis (SCFE) and normal hips. Methods We identified pelvic CT of 51 patients (55% male; mean 12.7 years (sd 1.9; 8-15)) with stable SCFE. In all, 16 of 51 hips (31%) had mild, 14 (27%) moderate and 21 (41%) severe SCFE. A total of 80 patients (50% male; mean age 11.5 years (sd 2.3; 8 to 15)) with normal hips who underwent pelvic CT due to abdominal pain made up the control cohort. CT scans were segmented, and the femur was reformatted using 3D software. We measured t

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Revanasiddappa, Hosakere Doddarevanna, and M. A. Veena. "Highly sensitive spectrophotometric methods for the determination of olanzapine." Ecletica Quimica 33, no. 3 (2008): 47–51. http://dx.doi.org/10.26850/1678-4618eqj.v33.3.2008.p47-51.

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Highly sensitive and selective spectrophotometric methods (A and B) were developed for the determination of micro amounts of olanzapine (OLZ). Method A (direct method) is based on the oxidation of olanzapine with a known excess of iodine monochloride (ICl) in an acidic medium. Under the same condition, thymol blue was iodinated by unreacted ICl, and the absorbance of uniodinated thymol blue was measured at 536 nm. The decrease in ICl concentration is a measure of drug concentration. In method B (indirect method), oxidation of OLZ by a known excess of Ce(IV) in sulfuric acid medium followed by

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Bennett, Derrick A., Huaidong Du, Fiona Bragg, et al. "Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults." BMJ Open Diabetes Research & Care 7, no. 1 (2019): e000835. http://dx.doi.org/10.1136/bmjdrc-2019-000835.

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ObjectiveAim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity.Research design and methodsThe prospective China Kadoorie Biobank recruited ~512 000 adults from 10 diverse areas across China. Self-reported PA was estimated based on type, frequency and duration of specific types of PA, covering four domains (occupation, leisure, household and commuting). SLT was defined as hours per day spent watching television, reading or playing card gam

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Smeltzer, Matthew, Wei Liao, Carrie Fehnel, et al. "Smoking history requirement and lung cancer (LC) screening (LCS) eligibility disparities." Journal of Clinical Oncology 42, no. 16_suppl (2024): 8016. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.8016.

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8016 Background: LCS eligibility criteria are not optimal. US Preventive Services Task Force 2021 criteria (USPSTF21) expanded eligibility, but race and sex disparities persist. We evaluated how 4 modified criteria impact LCS eligibility. Methods: We analyzed data from all persons enrolled into LCS and a non-screening detected Lung Nodule Program (LNP) in a prospective community-based cohort. The LNP used Fleischner Society guidelines. We compared sex, race, and Area Deprivation Index (ADI) of LCS-eligible persons and LC patients diagnosed based on USPSTF21 (Age 50-80, 20 pack-years [PY], 15 y

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Mavromatis, Kreton, Konstantinos Aznaouridis, Ibhar Al Mheid, et al. "Circulating Proangiogenic Cell Activity Is Associated with Cardiovascular Disease Risk." Journal of Biomolecular Screening 17, no. 9 (2012): 1163–70. http://dx.doi.org/10.1177/1087057112454919.

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Vascular injury mobilizes bone marrow–derived proangiogenic cells into the circulation, where these cells can facilitate vascular repair and new vessel formation. We sought to determine the relationship between a new biomarker of circulating bone marrow–derived proangiogenic cell activity, the presence of atherosclerotic cardiovascular disease (CVD) and its risk factors, and clinical outcomes. Circulating proangiogenic cell activity was estimated using a reproducible angiogenic colony-forming unit (CFU-A) assay in 532 clinically stable subjects aged 20 to 90 years and ranging in the CVD risk s

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Giovanelli, Nicola, Paolo Taboga, Enrico Rejc, Bostjan Simunic, Guglielmo Antonutto, and Stefano Lazzer. "Effects of an Uphill Marathon on Running Mechanics and Lower-Limb Muscle Fatigue." International Journal of Sports Physiology and Performance 11, no. 4 (2016): 522–29. http://dx.doi.org/10.1123/ijspp.2014-0602.

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Purpose:To investigate the effects of an uphill marathon (43 km, 3063-m elevation gain) on running mechanics and neuromuscular fatigue in lower-limb muscles.Methods:Maximal mechanical power of lower limbs (MMP), temporal tensiomyographic (TMG) parameters, and muscle-belly displacement (Dm) were determined in the vastus lateralis muscle before and after the competition in 18 runners (age 42.8 ± 9.9 y, body mass 70.1 ± 7.3 kg, maximal oxygen uptake 55.5 ± 7.5 mL · kg−1 · min−1). Contact (tc) and aerial (ta) times, step frequency (f), and running velocity (v) were measured at 3, 14, and 30 km and

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Rutley, B. D., and R. J. Hudson. "Seasonal energetic parameters of free-grazing bison (Bison bison)." Canadian Journal of Animal Science 80, no. 4 (2000): 663–71. http://dx.doi.org/10.4141/a99-114.

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Seasonal energetic parameters of yearling bison were estimated using the bite-count and single marker methods (fieldtrials) during each solstice and equinox between June 1994 and December 1995. To calibrate the marker method and to provide a controlled estimate of seasonal requirements, balance trials were conducted in metabolism crates during winter solstice 1994 and summer solstice 1995 (pen trials). In pen trials, actual metabolizable energy (ME) intake was lower (P < 0.01) during winter (528 ± 51 kJ W−0.75 d−1) than in summer (917 ± 69 kJ W−0.75 d−1). Similarly, in field trials, estimat

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Borrelli, Melissa, Adele Corcione, Roberto Rongo, et al. "Obstructive Sleep Apnoea in Children with Down Syndrome: A Multidisciplinary Approach." Journal of Personalized Medicine 13, no. 1 (2022): 71. http://dx.doi.org/10.3390/jpm13010071.

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A comprehensive evaluation of obstructive sleep apnoea (OSA) may allow for the development of more efficient management of Down syndrome (DS). We aimed to evaluate the effect of a multidisciplinary approach to DS with OSA. A total of 48 DS children aged 4–12 years were prospectively investigated with nasal endoscopy, orthodontic examination, and overnight polygraphy (PG); the Italian Child Sleep Habits Questionnaire (CSHQ-IT) was filled out by the mothers. The total CSHQ-IT score was 63 (96% of children reporting sleep problems). The major ear, nose, and throat characteristics were enlarged pa

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Gonzalez Velez, Miguel, Narjust Duma, Larysa Jessica Sanchez, Ramya Undamatla, Jose Ruiz Mino, and Martin Gutierrez. "Predictors of recurrence in stage I/II colorectal cancer: Analysis of a single institution’s experience for over 24 years." Journal of Clinical Oncology 34, no. 4_suppl (2016): 534. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.534.

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534 Background: Surgical resection remains a mainstay of treatment for localized colorectal cancer (CRC). However, up to 35% of patients (pts) develop recurrence with a significant decrease in overall survival. The aim of this study was to evaluate clinical characteristics and specific predictors of recurrence for stage I/II CRC Methods: We performed a retrospective analysis of 2310 pts diagnosed with stage I/II CRC at our institution between 1990 and 2013, with a minimum follow up of 24 months. Tumor characteristics and recurrence data were studied. Cox regression was used for statistical ana

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Lindholm, Anders, Göran Lundgren, Ingela Fehrman, et al. "Acute rejection episodes in cyclosporine‐treated cadaver kidney recipients." Clinical Transplantation 2, no. 4 (1988): 194–200. http://dx.doi.org/10.1111/j.1399-0012.1988.tb00504.x.

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A total of 532 acute rejection episodes were registered in 621 consecutive cadaveric renal allograft recipients treated with cyclosporine (CyA) and low dose prednisolone. Fifty‐seven percent of the patients experienced acute rejection. The occurrence of a rejection episode was an important risk factor for graft survival and acute rejection accounted for 51% of the 104 grafts lost. The 1 year graft survival rate was 59 and 82%, respectively, in patients who did or did not experience acute rejection (p < 0.001). Factors that correlated with an increased rejection frequency were the presence o

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Mantilla, M. J., G. Rodríguez Salas, A. M. Santos, et al. "AB1069 GENDER DIFFERENCES IN PRESENTATION, CLASSIFICATION, AND DISEASE ACTIVITY OF SPONDYLOARTHRITIS: RESULTS FROM GESPA COLOMBIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1755.3–1756. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3922.

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BackgroundSpondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder composed of axial (AxSpA) and peripheral (pSpA) disease. AxSpA is further subdivided into radiographic AxSpA (r-AxSpA) and non-radiographic AxSpA (r-AxSpA). Historically, SpA was mostly a male disease. However, actual disease awareness has changed the approach, allowing women to be included to a greater extent.ObjectivesFew studies have explored the male and female disease features in Latin American population. The aim of this study was to examine the clinical presentation, disease onset characteristics, metrology,

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Matthews, Marc R., Sara Calder, Areta Kowal-Vern, Philomene Spadafore, Karen J. Richey, and Kevin N. Foster. "531 The Effect of Burn Wound Size on Caloric Requirements: A Correlation of Nutritional Changes to the Clinical State." Journal of Burn Care & Research 42, Supplement_1 (2021): S113—S114. http://dx.doi.org/10.1093/jbcr/irab032.181.

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Abstract Introduction Caloric intake has been a vital component for burn wound healing and recovery. The hypothesis was that caloric requirements are based on injury severity & post-burn week as predicated by indirect calorimetry (IC)/predictive equations. Methods This was a retrospective chart review of 115 burn patients (2012–2017). Caloric requirements were determined by the Curreri equation [which includes % total body surface area (TBSA)] and IC for a 5-week period provided mainly by enteral nutrition. Patients received supplements and total parenteral nutrition as needed. Results The

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Cadranel, J., M. Beau-Faller, A. Mauguen, et al. "Biological and clinical prognostic factors in patients with advanced non-small-cell cancer (NSCLC) treated by erlotinib: Preliminary results of the ERMETIC cohort." Journal of Clinical Oncology 27, no. 15_suppl (2009): 8079. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.8079.

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8079 Background: Although it has been suggested that results of EGFR-IHC, EGFR-FISH and EGFR and KRAS mutations are predictive of EGFR-TKIs efficacy, they are not used in clinical practice. ERMETIC is a French NCI granted prospective study aiming to facilitate implementation of these biomarkers in France. Methods: After a preliminary phase of validation in 16 French centers, these biomarkers were studied in available tumor specimens collected from all consecutive NSCLC patients (pts) treated by erlotinib, for the first time. Patients were followed-up until progression or death. Demographic, cl

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Yogo, Norihiro, Katherine Shihadeh, Heather Young, et al. "Intervention to Reduce Broad-Spectrum Antibiotics and Treatment Durations Prescribed at the Time of Hospital Discharge: A Novel Stewardship Approach." Infection Control & Hospital Epidemiology 38, no. 5 (2017): 534–41. http://dx.doi.org/10.1017/ice.2017.10.

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OBJECTIVEFor most common infections requiring hospitalization, antibiotic treatment is completed after hospital discharge. Postdischarge therapy is often unnecessarily broad spectrum and prolonged. We developed an intervention to improve antibiotic selection and shorten treatment durations.DESIGNSingle center, quasi-experimental retrospective cohort studyMETHODSPatients prescribed oral antibiotics at hospital discharge before (July 2012–June 2013) and after (October 2014–February 2015) an intervention consisting of (1) institutional guidance for oral step-down antibiotic selection and duration

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Syed, Ilias Basha, Ghosh Somnath, Vinoth Kumar K., Ramesh B., Hema Prakash Kumari P., and Sukumar Ethirajan. "Synthesis, characterization and antibacterial activity of fumaric acid incorporated silver nanoparticle hydrogel." Journal of Indian Chemical Society Vol. 96, Nov 2019 (2019): 1409–12. https://doi.org/10.5281/zenodo.5641999.

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Department of Research and Development, Saveetha Institute of Medical and Technical Sciences (DeemedUniversity), Thandalam, Chennai-602 105, India <em>E-mail:</em> syediliasbasha@gmail.com, drsuku3@gmail.com Department of Chemistry, Indian Institute of Petroleum and Energy, Visakhapatnam-530 003, Andhra Pradesh, India <em>E-mail</em>: ghoshmnth@gmail.com VPro Biotech, 51-Arumparthapuram Main Road, Puducherry-605 110, India <em>E-mail:</em> kvinothkumarphd@gmail.com Department of Pharmacology, GITAM Institute of Medical Sciences and Research (Deemed University), Rushikonda, Visakhapatnam-530 04

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Catzen, Hannah Z., Christopher Kobe, Paul Abrahamse, Kevin C. Ward, Sarah T. Hawley, and Christine M. Veenstra. "Communication and fear of recurrence in colorectal cancer survivors and their partners." JCO Oncology Practice 19, no. 11_suppl (2023): 502. http://dx.doi.org/10.1200/op.2023.19.11_suppl.502.

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502 Background: Little is known about how colorectal (CRC) survivors and their partners communicate about cancer or about their fears of recurrence. CRC survivors who are discordant with their partner in communication about cancer and fear of recurrence may have worse health-related quality of life (HrQoL), but this is not known. Methods: From 2019-2020 we surveyed survivors of stage III CRC diagnosed 2014-2018 at an academic cancer center, a community oncology practice, and the Georgia cancer registry, and their domestic partners. We measured dyadic communication about cancer using the 23-ite

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Humphrey, J. A., A. Woods, and A. H. N. Robinson. "The epidemiology and trends in the surgical management of calcaneal fractures in England between 2000 and 2017." Bone & Joint Journal 101-B, no. 2 (2019): 140–46. http://dx.doi.org/10.1302/0301-620x.101b2.bjj-2018-0289.r3.

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Aims This paper documents the epidemiology of adults (aged more than 18 years) with a calcaneal fracture who have been admitted to hospital in England since 2000. Secondary aims were to document whether publication of the United Kingdom Heel Fracture Trial (UK HeFT) influenced the proportion of patients admitted to hospital with a calcaneal fracture who underwent surgical treatment, and to determine whether there has been any recent change in the surgical technique used for these injuries. Patients and Methods In England, the Hospital Episode Statistics (HES) data are recorded annually. Betwee

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Kuendgen, Andrea, Michael Lauseker, Alan F. List, et al. "Lenalidomide Treatment Is Not Related to AML Progression Risk but Is Associated with a Survival Benefit in RBC Transfusion-Dependent Patients with IPSS Low- or Int-1-Risk MDS with del5q: Results From a Comparative Study." Blood 118, no. 21 (2011): 119. http://dx.doi.org/10.1182/blood.v118.21.119.119.

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Abstract Abstract 119 Background: Lenalidomide (LEN) treatment resulted in RBC transfusion independence for ≥ 8 wks in 51–67% of patients (pts) and cytogenetic response in 25–73% of pts with lower-risk MDS and del5q in 2 large multicenter trials (MDS-003 and -004) (List A et al. NEJM 2006;355:1456–65; Fenaux P et al. Blood 2011; doi:10.1182/blood-2011-01-330126). However, these studies were either single-arm or allowed early crossover to LEN, thus data on the influence of LEN on AML progression and overall survival (OS) is lacking. Aims: To assess the risk of AML progression and death in LEN-t

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Smith, Natalie Grier, Warren B. Fingrut, Nicholas Waters, et al. "Disparities in Microbiota Diversity Impacting Non-European Recipients of 8/8 HLA-Matched Unrelated Donor Transplantation." Blood 144, Supplement 1 (2024): 3498. https://doi.org/10.1182/blood-2024-212186.

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Introduction. Although microbiome diversity, patient ancestry, and socioeconomic status (SES) are each associated with allogeneic hematopoietic cell transplantation (allo-HCT) outcomes, the relationships between these variables in the alloHCT context has not been described. We hypothesized that patient ancestry and SES associates with microbiome patterns post-HCT. Methods. We evaluated alloHCT recipients at our Center 1/2015-6/2020 who provided ≥1 stool sample from D-40 to D+365. Patient SES was classified as low if they had an area deprivation index ≥60% or were on medicaid or patient financi

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Feng, Zinan, Yu Zhang, Hui Liu, Sijian Yu, Qifa Liu, and Li Xuan. "High-Dose Cytarabine with Idarubicin Versus High-Dose Cytarabine within First Consolidation for Acute Myeloid Leukemia in First Complete Remission: An Open-Label, Multicenter, Randomized, Phase 3 Trial." Blood 144, Supplement 1 (2024): 972. https://doi.org/10.1182/blood-2024-200583.

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Backgrounds ： Whether adding anthracycline to intermediate- or high-dose cytarabine as consolidation is beneficial remains unclear in acute myeloid leukemia (AML). We investigated the efficacy and safety of high-dose cytarabine with idarubicin as consolidation for AML in first complete remission (CR1). Methods: We performed the open-label, randomized phase 3 trial at 16 hospitals in China. Eligible AML patients in CR1 were randomly assigned (1:1) to receive either high-dose cytarabine with idarubicin (IA3+3) (idarubicin 10mg/m2, d1-3 and cytarabine 2g/m2, q12h, d1-3) or high-dose cytarabine (H

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Vizek, M., C. K. Pickett, and J. V. Weil. "Interindividual variation in hypoxic ventilatory response: potential role of carotid body." Journal of Applied Physiology 63, no. 5 (1987): 1884–89. http://dx.doi.org/10.1152/jappl.1987.63.5.1884.

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There is considerable interindividual variation in ventilatory response to hypoxia in humans but the mechanism remains unknown. To examine the potential contribution of variable peripheral chemorecptor function to variation in hypoxic ventilatory response (HVR), we compared the peripheral chemoreceptor and ventilatory response to hypoxia in 51 anesthetized cats. We found large interindividual differences in HVR spanning a sevenfold range. In 23 cats studied on two separate days, ventilatory measurements were correlated (r = 0.54, P less than 0.01), suggesting stable interindividual differences

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Metzger Filho, Otto, Giuseppe Viale, Lorenzo Trippa, et al. "HER2 heterogeneity as a predictor of response to neoadjuvant T-DM1 plus pertuzumab: Results from a prospective clinical trial." Journal of Clinical Oncology 37, no. 15_suppl (2019): 502. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.502.

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502 Background: HER2 targeted therapy without chemotherapy may be insufficient to completely eradicate a HER2+ cancer in cases of significant intratumor HER2 heterogeneity (ITH-HER2). Methods: We conducted a single-arm phase II study enrolling centrally confirmed HER2+ breast cancer. Pts received 6 cycles of T-DM1 plus Pertuzumab before surgery. Central ITH-HER2 was assessed on baseline ultrasound-guided core biopsies from 2 distinct areas of each tumor (3 cores/site). ITH-HER2 was defined as at least one of the six areas demonstrating either 1) HER2 positivity by FISH in > 5% and < 50%

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Moran, Sergio V., Francisco Montiel, Guillermo Acuña, et al. "Cephradine and cefazolin plasma levels during cardiac surgery." Perfusion 1, no. 1 (1986): 41–45. http://dx.doi.org/10.1177/026765918600100105.

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A prospective, randomized, double-blind study was carried out to evaluate two prophylactic regimes in patients undergoing cardiac surgery with cardiopulmonary bypass. Antibiotic plasma levels were measured in fifty consecutive adult patients undergoing valve and coronary surgery. They were divided into two comparable groups of 25 patients, each matched in age, sex, type of operation and duration of cardiopulmonary bypass. Group 1 received 1 g of cephradine with the anaesthetic premedication, 1 g in the prime of the oxygenator and 1 g every six hours during the first 72 hours of the postoperati

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Bradley, L. A., D. D. Johnson, G. E. Palomaki, J. E. Haddow, N. H. Robertson, and R. M. Ferrie. "Hereditary haemochromatosis mutation frequencies in the general population." Journal of Medical Screening 5, no. 1 (1998): 34–36. http://dx.doi.org/10.1136/jms.5.1.34.

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Objectives This study aims to expand our knowledge of the general population frequency of two mutations, C282Y and H63D, identified in the candidate gene for hereditary haemochromatosis, and to determine whether the testing can be performed using routinely obtained cheek-brush (buccal) samples. Setting Banked buccal lysate samples, randomised and coded for anonymity, from a cohort of couples who underwent prenatal cystic fibrosis screening in Maine. Methods A multiplex ARMS test was performed on buccal cell lysates to identify the two mutations. Results Genotype frequencies found among the 100

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Averina, I. I., M. Yu Mironenko, L. A. Glushko, S. A. Donakanyan, and L. A. Bokeria. "Left heart remodeling as a risk factor for atrial fibrillation in patients after surgery of acquired heart defects." Russian Journal of Cardiology 28, no. 7 (2023): 5323. http://dx.doi.org/10.15829/1560-4071-2023-5323.

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Aim. To identify risk factors for atrial fibrillation (AF) in patients with aortic and mitral defects after surgical treatment.Material and methods. A total of 112 patients with aortic and mitral defects (excluding patients with mitral stenosis) were examined: 90 men and 22 women aged 18 to 72 years (median age, 51(35;57) years). Patients were examined initially before and after surgery (in terms of 8-14 days and after 12-36 months). The peak left atrial (LA) longitudinal strain (PALS) was determined at LA reservoir phase. The following endpoints were chosen: the presence of AF and atrial flut

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Aguirre, Luis E., Jan Philipp Bewersdorf, Yiwen Liu, et al. "Comparative Analysis of Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients Harboring Very-High Risk Cytogenetics." Blood 144, Supplement 1 (2024): 4267. https://doi.org/10.1182/blood-2024-202744.

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Background: Dismal survival outcomes are characteristic of pts with AML harboring very-high risk cytogenetics (vHRC), which can be attributed to aggressive disease biology and low and poorly durable response rates to conventional cytotoxic chemotherapy. Allogeneic hematopoietic stem cell transplant (alloSCT) is the preferred treatment strategy after major disease reduction with initial chemotherapy. However, it is unclear whether pts with AML-vHRC should be treated with intensive chemotherapy (IC) or hypomethylating agents plus venetoclax (HMA+ven) to achieve such responses. In this large mult

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Archer, Natasha, Alexandra Power-Hays, Erin Auriel Hendry, et al. "Ketamine Use in Hospitalized Children and Young Adults with Sickle Cell Disease." Blood 144, Supplement 1 (2024): 3682. https://doi.org/10.1182/blood-2024-194763.

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Background National societies including the American Society of Hematology recommend ketamine, an N-Methyl-D-Aspartate receptor antagonist, as an opioid sparing adjunct for the treatment of refractory pain in sickle cell disease (SCD). Little is known regarding how it is being used nationally to treat hospitalized individuals with SCD. Aims: To describe ketamine use over time and examine associations between ketamine use and healthcare utilization outcomes in patients with SCD admitted to children's hospitals. Methods: We performed a multi-center cross-sectional study of individuals ≥ 6 months

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Peerenboom, Rayne, Sarah Ackroyd, Chuanhong Liao, Aarthi Koripelly, and Nita Lee. "Abstract B117: Disparities in non-surgical admissions for survivors of cervical cancer: Understanding morbidity and survivorship needs through hospital admissions." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): B117. http://dx.doi.org/10.1158/1538-7755.disp22-b117.

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Abstract Purpose: To utilize data on hospital admissions among patients with cervical cancer during treatment and long-term surveillance to better understand disease and treatment related burdens, explore inpatient utilization of services, and identify risk factors for admission. Methods: Retrospective chart review was performed on patients treated for cervical cancer from 2014 to 2020 at a single academic institution. Clinical, demographic and treatment information and hospital admission characteristics were collected. Discharge diagnoses were grouped and summarized with descriptive statistic

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Polonskaya, Ya V., E. V. Kashtanova, E. M. Stakhneva, et al. "The level of adipokines in young people with hypertension and abdominal obesity." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 29, no. 1 (2022): 51–57. http://dx.doi.org/10.18705/1607-419x-2022-28-6-51-57.

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Objective. To investigate the adipokine blood profile in young people with hypertension (HTN) and abdominal obesity (AO). Design and methods. In total. 530 people were included in the study, including 267 people with HTN, of which 169 had AO. In the control group (without HTN) there were 263 people comparable to the study group by gender and age. Among them there were 106 people with AO. The blood levels of adiponectin, adipsin, lipocalin-2, resistin and plasminogen activator inhibitor-1 (PAI-1) were determined in all examined patients by multiplex analysis. Statistical data processing was car

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Fukahori, Masaru, Yoshinobu Okabe, Mototsugu Shimokawa, et al. "Efficacy of second-line chemotherapy after standard combination chemotherapy in patients with metastatic pancreatic cancer: The results from the NAPOLEON study." Journal of Clinical Oncology 38, no. 4_suppl (2020): 661. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.661.

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661 Background: Gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX) have been established as standard first-line combination chemotherapy (CTx) for patients with metastatic pancreatic cancer (MPC). However, the efficacy of second-line CTx and the significance of combination CTx in clinical practice are unclear. We therefore investigated the efficacy of second-line CTx in patients with MPC. Methods: Data were collected from CTx-naive MPC patients treated with first-line combination CTx at 14 hospitals in the Kyushu area of Japan from December 2013 to June 2018. The median overall surviva

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Ragimova, A. A., D. S. Petelin, A. N. Galyautdinova, V. A. Tolmacheva, and B. A. Volel. "Rhythmic transcranial magnetic stimulation in the treatment of cervical dystonia and comorbid mental disorders." Neurology, Neuropsychiatry, Psychosomatics 16, no. 3 (2024): 38–43. http://dx.doi.org/10.14412/2074-2711-2024-3-38-43.

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Cervical dystonia (CD) is a common form of movement disorder with a high incidence of comorbid mental disorders. Rhythmic transcranial magnetic stimulation (rTMS) is effective in depression and other mental disorders, but its efficacy in CD with comorbid mental disorders has been poorly studied.Objective: to investigate the efficacy of rTMS in CD and comorbid mental disorders.Material and methods. Seventeen patients with CD underwent a course of 10 rTMS sessions (protocol: 1 Hz, 600 pulses to the left primary motor cortex). The severity of mental disorders, quality of life and severity of cerv

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Kozińska, Urszula, Jordi Gras-Ozimek, Aleksander Gras-Ozimek, Sylwia Skwira, and Rafał Oleszczuk. "The use of the KTP 532 nm vascular laser in the treatment of erythema and telangiectasia caused by low temperature exposure - case report." Journal of Education, Health and Sport 12, no. 9 (2022): 651–57. https://doi.org/10.12775/JEHS.2022.12.09.078.

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<strong>Kozińska</strong><strong>, </strong><strong>Urszula</strong><strong>,</strong><strong> Gras-Ozimek</strong><strong>,</strong><strong> Jordi</strong><strong>,</strong><strong> Gras-Ozimek</strong><strong>,</strong><strong> Aleksander</strong><strong>,</strong><strong> Skwira</strong><strong>,</strong> <strong>Sylwia</strong><strong>,</strong><strong> Oleszczuk</strong><strong>,</strong> <strong>Rafał</strong><strong>. </strong><strong>The use of the KTP 532 nm vascular laser in the treatment of erythema and telangiectasia caused by low temperature

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Liu, KeXin, YaQian Xu, ChaoYi Ma, et al. "Efficacy of a Virtual 3D Simulation–Based Digital Training Module for Building Dental Technology Students’ Long-Term Competency in Removable Partial Denture Design: Prospective Cohort Study." JMIR Serious Games 12 (April 5, 2024): e46789-e46789. http://dx.doi.org/10.2196/46789.

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Abstract Background Removable partial denture (RPD) design is crucial to long-term success in dental treatment, but shortcomings in RPD design training and competency acquisition among dental students have persisted for decades. Digital production is increasing in prevalence in stomatology, and a digital RPD (D-RPD) module, under the framework of the certified Objective Manipulative Skill Examination of Dental Technicians (OMEDT) system reported in our previous work, may improve on existing RPD training models for students. Objective We aimed to determine the efficacy of a virtual 3D simulatio

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Shukhov, Oleg, Margarita Gurianova, Ekaterina Chelysheva, et al. "Results of the Molecular Response Evaluation and TKI Dose Adjustment in Chronic Myeloid Leukemia Patients in Prospective Study of Reduction and Discontinuation Treatment of TKI (READIT)." Blood 144, Supplement 1 (2024): 4539. https://doi.org/10.1182/blood-2024-199962.

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Introduction: The feasibility of tyrosine kinase inhibitors (TKI) dose reduction before treatment-free remission (TFR) observation in chronic myeloid leukemia (CML) patients (pts) with deep molecular response (DMR) was confirmed in several trials. However, a unified step-by-step dose de-escalation and re-escalation scheme for each TKI has not been developed. Aim: To provide the data of major molecular response (MMR, BCR::ABL1≤0.1%) and deep molecular response (DMR, BCR::ABL1≤0.01%) loss and recovery in the trial READIT (NCT 04578847). Methods: The trial had 2 consecutive phases: 1) TKI 2-step

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